O. Hucke

发表

Human Intestinal Transporter Database: QSAR Modeling and Virtual Profiling of Drug Uptake, Efflux and Interactions

A. Tropsha, Alexander Sedykh, D. Fourches, 2013, Pharmaceutical Research.

Development of Specific “Drug‐Like Property” Rules for Carboxylate‐Containing Oral Drug Candidates

O. Hucke, P. Bonneau, A. Böcker, 2010, ChemMedChem.

Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites.

D. Chakrabarti, F. Buckner, C. Verlinde, 2005, Angewandte Chemie.

Inhibition of HIV-1 capsid assembly: optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold.

J. Duan, O. Hucke, M. Garneau, 2012, Bioorganic & medicinal chemistry letters.

Sequence analysis reveals new membrane anchor of reaction centre‐bound cytochromes possibly related to PufX

O. Hucke, G. Drews, E. Schiltz, 2003, FEBS letters.

Molecular dynamics simulations and structure-based rational design lead to allosteric HCV NS5B polymerase thumb pocket 2 inhibitor with picomolar cellular replicon potency.

O. Hucke, P. Bonneau, C. Brochu, 2014, Journal of medicinal chemistry.

The effect of the P1 side chain on the binding of optimized carboxylate and activated carbonyl inhibitors of the hepatitis C virus NS3 protease.

O. Hucke, S. LaPlante, S. Kawai, 2010, Future medicinal chemistry.

Revealing Atropisomer Axial Chirality in Drug Discovery

O. Hucke, S. LaPlante, A. Jakalian, 2011, ChemMedChem.

Assessing atropisomer axial chirality in drug discovery and development.

O. Hucke, S. LaPlante, P. Edwards, 2011, Journal of medicinal chemistry.

Phosphatidylinositol 4-Kinase III Beta Is Essential for Replication of Human Rhinovirus and Its Inhibition Causes a Lethal Phenotype In Vivo

O. Hucke, M. Garneau, J. Neyts, 2013, Antimicrobial Agents and Chemotherapy.

Action of Dipeptidyl Peptidase‐4 Inhibitors on SARS‐CoV‐2 Main Protease

O. Hucke, H. Nar, G. Schnapp, 2020, ChemMedChem.

The protein farnesyltransferase inhibitor Tipifarnib as a new lead for the development of drugs against Chagas disease.

M. Gelb, F. Buckner, C. Verlinde, 2005, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus.

O. Hucke, M. Garneau, C. Brochu, 2013, Bioorganic & medicinal chemistry letters.

Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: addressing configurational instability through scaffold modification.

O. Hucke, P. Bonneau, S. Morin, 2013, Bioorganic & medicinal chemistry letters.

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly.

O. Hucke, P. Bonneau, C. Yoakim, 2011, Bioorganic & medicinal chemistry letters.

Discovery and structural characterization of a new inhibitor series of HIV-1 nucleocapsid function: NMR solution structure determination of a ternary complex involving a 2:1 inhibitor/NC stoichiometry.

O. Hucke, P. Bonneau, S. Titolo, 2013, Journal of molecular biology.

Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: structure-activity relationships (SAR) of the C3-phenyl moiety.

J. Duan, O. Hucke, M. Garneau, 2013, Bioorganic & medicinal chemistry letters.

Cover Picture: Revealing Atropisomer Axial Chirality in Drug Discovery (ChemMedChem 3/2011)

O. Hucke, S. LaPlante, A. Jakalian, 2011 .

Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase

D. Chakrabarti, M. Gelb, F. Buckner, 2007, Antimicrobial Agents and Chemotherapy.

Sesquiterpene lactones as inhibitors of human neutrophil elastase.

O. Hucke, I. Merfort, R. Murillo, 2002, Bioorganic & medicinal chemistry.

Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase.

P. Rathod, M. Gelb, C. Verlinde, 2007, Molecular and biochemical parasitology.

Resistance to a Protein Farnesyltransferase Inhibitor in Plasmodium falciparum*

P. Rathod, D. Chakrabarti, M. Gelb, 2005, Journal of Biological Chemistry.

Bound Structure and Biochemical Mechanism of Action of BI 201335, a Potent, Non-covalent Inhibitor of HCV NS3-NS4A Protease

O. Hucke, P. White, D. Thibeault, 2010 .

Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: discovery of a quinazolinone chemotype.

Araz Jakalian, Martin Poirier, Cédrickx Godbout, 2013, Bioorganic & medicinal chemistry letters.

Multiple Binding Sites Contribute to the Mechanism of Mixed Agonistic and Positive Allosteric Modulators of the Cannabinoid CB1 Receptor.

Noureldin Saleh, Christofer S Tautermann, Esther Schmidt, 2018, Angewandte Chemie.

Binding affinities and protein ligand complex geometries of nucleotides at the F1 part of the mitochondrial ATP synthase obtained by ligand docking calculations

Michael Börsch, Thomas Steinbrecher, Stefan Steigmiller, 2002, FEBS letters.

Exploring the primary electron acceptor (QA)-site of the bacterial reaction center from Rhodobacter sphaeroides. Binding mode of vitamin K derivatives.

O. Hucke, R. Schmid, A. Labahn, 2002, European journal of biochemistry.

Human Intestinal Transporter Database: QSAR Modeling and Virtual Profiling of Drug Uptake, Efflux and Interactions

A. Tropsha, Alexander Sedykh, D. Fourches, 2013, Pharmaceutical Research.

Combined X-ray, NMR, and Kinetic Analyses Reveal Uncommon Binding Characteristics of the Hepatitis C Virus NS3-NS4A Protease Inhibitor BI 201335*

O. Hucke, P. White, N. Goudreau, 2011, The Journal of Biological Chemistry.

Enantiomeric atropisomers inhibit HCV polymerase and/or HIV matrix: characterizing hindered bond rotations and target selectivity.

O. Hucke, S. LaPlante, R. Coulombe, 2014, Journal of medicinal chemistry.

Structure-based design of novel HCV NS 5 B thumb pocket 2 allosteric inhibitors with submicromolar gt 1 replicon potency : Discovery of a

J. Duan, O. Hucke, R. Coulombe, 2013 .