I. Kariv

发表

Use of optophoresis as an in vitro predictor of cell response to chemotherapy for chronic lymphocytic leukemia

P. Marchand, M. Nerenberg, I. Kariv, 2006, Leukemia & lymphoma.

Improvement of "hit-to-lead" optimization by integration of in vitro HTS experimental models for early determination of pharmacokinetic properties.

I. Kariv, D. Kassel, R. Rourick, 2002, Combinatorial chemistry & high throughput screening.

Microfluidic sorting of mammalian cells by optical force switching

Elinore M Mercer, P. Marchand, A. Forster, 2005, Nature Biotechnology.

Identification of predictive genetic signatures of Cytarabine responsiveness using a 3D acute myeloid leukaemia model

I. Kariv, Sarah Javaid, R. Cristescu, 2019, Journal of cellular and molecular medicine.

Advances in high-dimensional mass cytometry cell and tissue analyses for translational biomarker discovery

I. Kariv, Elma Kadić, 2017 .

Efficient identification of novel leads by dynamic focused screening: PDK1 case stud.

Dongyu Sun, Ekaterina Bobkova, I. Kariv, 2010, Combinatorial chemistry & high throughput screening.

Analysis of protein-peptide interaction by a miniaturized fluorescence polarization assay using cyclin-dependent kinase 2/cyclin E as a model system.

I. Kariv, K. Oldenburg, N. Graciani, 1999, Analytical biochemistry.

Cell-Based Analysis of Drug Response Using Moving Optical Gradient Fields

Tina S. Nova, I. Kariv, P. McNeeley, 2006 .

Discovery of PDK1 Kinase Inhibitors with a Novel Mechanism of Action by Ultrahigh Throughput Screening

I. Kariv, P. Blume-Jensen, J. Andersen, 2010, The Journal of Biological Chemistry.

CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.

I. Kariv, K. Vaddi, M. Covington, 2007, Bioorganic & medicinal chemistry letters.

Determination of EPAC2 function using EPAC2 null Min6 sublines generated through CRISPR-Cas9 technology

I. Kariv, Haiyan Xu, Ruojing Yang, 2018, Molecular and Cellular Endocrinology.

Selective Enrichment of Major Histocompatibility Complex Class R-specific Autoreactive T Cells in the Thymic Thy0 Subset

I. Kariv, R. Hardy, K. Hayakawa, 2003 .

Selective enrichment of major histocompatibility complex class II- specific autoreactive T cells in the thymic Thy0 subset [published erratum appears in J Exp Med 1993 Aug 1;178(2):following 763]

I. Kariv, R. Hardy, K. Hayakawa, 1993, The Journal of experimental medicine.

Analysis of the site of interaction of CD28 with its counter-receptors CD80 and CD86 and correlation with function.

I. Kariv, R. Sweet, A. Truneh, 1996, Journal of immunology.

Identification of Inhibitors of Bacterial Transcription/Translation Machinery Utilizing a Miniaturized 1536-Well Format Screen

I. Kariv, T. Chung, K. Oldenburg, 2001, Journal of biomolecular screening.

Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor

Irena Ivanovska, C. Chiu, I. Kariv, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Drug response measurements using optical forces

P. Marchand, A. Forster, I. Kariv, 2003 .

Age- and strain-related differences in murine spleen cell responses to different activation signals.

I. Kariv, F. Ferguson, F. Confer, 1992, Cellular immunology.

Two distinct non‐T helper type 2 interleukin‐4 cell subsets in mice as revealed by single‐cell cytokine analysis

I. Kariv, R. Hardy, K. Hayakawa, 1994, European journal of immunology.

Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitors.

I. Kariv, C. Moxham, Thomas A. Miller, 2012, Bioorganic & medicinal chemistry letters.

3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors.

M. Tota, S. Krauss, I. Kariv, 2006, Bioorganic & medicinal chemistry letters.

Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.

Andrew M Haidle, Matthew L. Maddess, J. Cumming, 2022, Journal of medicinal chemistry.

From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: the discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis.

I. Kariv, S. Mandlekar, A. Tebben, 2008, Bioorganic & medicinal chemistry letters.

Development of High-Throughput TR-FRET and AlphaScreen® Assays for Identification of Potent Inhibitors of PDK1

I. Kariv, T. Rush, J. Andersen, 2009, Journal of biomolecular screening.

Effect of cryopreservation on delineation of immune cell subpopulations in tumor specimens as determinated by multiparametric single cell mass cytometry analysis

R. Moniz, I. Kariv, An Chi, 2017, BMC Immunology.

Development of a Cell-Based Assay for Measurement of c-Met Phosphorylation Using AlphaScreenTM Technology and High-Content Imaging Analysis

I. Kariv, C. Moxham, Anjili Mathur, 2009, Journal of biomolecular screening.

MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.

C. Paweletz, K. Kunii, I. Kariv, 2010, Cancer research.

An orally available non-nucleotide STING agonist with antitumor activity

Andrew M Haidle, J. Cumming, I. Kariv, 2020, Science.

Integration of Affinity Selection–Mass Spectrometry and Functional Cell-Based Assays to Rapidly Triage Druggable Target Space within the NF-κB Pathway

Patrick J. Curran, Sujata Sharma, I. Kariv, 2016, Journal of biomolecular screening.

Use of moving optical gradient fields for analysis of apoptotic cellular responses in a chronic myeloid leukemia cell model.

Osman Kibar, Eugene Tu, Philippe J Marchand, 2004, Analytical biochemistry.

A multiplexed microfluidic system for evaluation of dynamics of immune-tumor interactions.

J T Borenstein, J. Chevillet, I. Kariv, 2018, Lab on a chip.

Analysis of CD28 Interactions with Its Cognate Counter-Receptors CD80 and CD86

D. Olive, I. Kariv, M. Hurle, 1996 .

Development of a high throughput equilibrium dialysis method.

I. Kariv, K. Oldenburg, I Kariv, 2001, Journal of pharmaceutical sciences.

Comparison of Automation Equipment in High Throughput Screening

Thomas D.Y. Chung, Ilona Kariv, P. J. Bouchard, 1998 .

Establishing and Validating Cellular Functional Target Engagement Assay for Selective IRAK4 Inhibitor Discovery

I. Kariv, Ruojing Yang, Jongwon Lim, 2021, SLAS discovery : advancing life sciences R & D.

Altered major histocompatibility complex restriction in the NK1.1+Ly- 6Chi autoreactive CD4+ T cell subset from class II-deficient mice [published erratum appears in J Exp Med 1995 Feb 1;181(2):823]

I. Kariv, R. Hardy, K. Hayakawa, 1994, The Journal of experimental medicine.

I. Kariv, E. Sharlow, F. Ferguson, 1991, Immunology letters.

A Simplified Scintillation Proximity Assay for Fatty Acid Synthase Activity: Development and Comparison with Other FAS Activity Assays

I. Kariv, Nathan W Bays, Armetta D. Hill, 2009, Journal of biomolecular screening.

Assay Miniaturization: Developing Technologies and Assay Formats

I. Kariv, T. Chung, K. Oldenburg, 2001 .

Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors

I. Kariv, X. Chai, X. Fradera, 2020, SLAS discovery : advancing life sciences R & D.

High-Throughput Analysis of HGF-Stimulated Cell Scattering

I. Kariv, A. Szewczak, B. Pan, 2008, Journal of biomolecular screening.

Optical forces for noninvasive cellular analysis.

Eugene Tu, Philippe J Marchand, Haichuan Zhang, 2003, Applied optics.

High Throughput Quantitation of cAMP Production Mediated by Activation of Seven Transmembrane Domain Receptors

Kevin R. Oldenburg, I. Kariv, K. Oldenburg, 1999, Journal of biomolecular screening.

Development of a Miniaturized 384-Well High Throughput Screen for the Detection of Substrates of Cytochrome P450 2D6 and 3A4 Metabolism

I. Kariv, M. Fereshteh, K. Oldenburg, 2001, Journal of biomolecular screening.

Cellular analysis based on moving infrared optical gradient fields

Philippe J. Marchand, Sadik C. Esener, Rong Yang, 2003, SPIE Optics + Photonics.

Quality Control Procedures for Dose-Response Curve Generation Using Nanoliter Dispense Technologies

Catherine Quintero, Craig Rosenstein, Bethany Hughes, 2007, Journal of biomolecular screening.

Integration of Affinity Selection–Mass Spectrometry and Functional Cell-Based Assays to Rapidly Triage Druggable Target Space within the NF-κB Pathway

Patrick J. Curran, Sujata Sharma, I. Kariv, 2016, Journal of biomolecular screening.

MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.

C. Paweletz, K. Kunii, I. Kariv, 2010, Cancer research.