J. Fitzgerald

发表

Systems biology and combination therapy in the quest for clinical efficacy

P. Sorger, B. Schoeberl, U. Nielsen, 2006, Nature chemical biology.

Therapeutically Targeting ErbB3: A Key Node in Ligand-Induced Activation of the ErbB Receptor–PI3K Axis

V. Grantcharova, B. Schoeberl, U. Nielsen, 2009, Science Signaling.

MM-141, an IGF-IR– and ErbB3-Directed Bispecific Antibody, Overcomes Network Adaptations That Limit Activity of IGF-IR Inhibitors

B. Schoeberl, U. Nielsen, J. Fitzgerald, 2013, Molecular Cancer Therapeutics.

Rapid optimization and prototyping for therapeutic antibody-like molecules

B. Schoeberl, U. Nielsen, J. Fitzgerald, 2013, mAbs.

Companion Diagnostic 64Cu-Liposome Positron Emission Tomography Enables Characterization of Drug Delivery to Tumors and Predicts Response to Cancer Nanomedicines

B. Hendriks, J. Fitzgerald, Helen Lee, 2018, Theranostics.

Gene expression profiles of human chondrocytes during passaged monolayer cultivation

Jiake Xu, Alan J Grodzinsky, A. Grodzinsky, 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Title: MM-141, an IGF-1R and ErbB3 directed bispecific antibody, overcomes network adaptations that limit activity of IGF-1R inhibitors

B. Schoeberl, U. Nielsen, J. Fitzgerald, 2013 .

Chondrocyte gene expression and intracellular signaling pathways in cartilage mechanotransduction

J. Fitzgerald, 2005 .

A phase 1 trial of intravenous liposomal irinotecan in patients with recurrent high-grade glioma

Jennie W. Taylor, Susan M. Chang, M. Prados, 2017, Cancer Chemotherapy and Pharmacology.

PERIPHERALLY-DERIVED AUTOLOGOUS T CELL THERAPY IN SOLID TUMOR PATIENTS

Shawn P. Carey, J. Fitzgerald, A. Shields, 2020 .

Extended topoisomerase 1 inhibition through liposomal irinotecan results in improved efficacy over topotecan and irinotecan in models of small-cell lung cancer

B. Hendriks, J. Fitzgerald, P. Bunn, 2017, Anti-cancer drugs.

Longitudinal tumor hypoxia imaging with [18F]FAZA-PET provides early prediction of nanoliposomal irinotecan (nal-IRI) treatment activity

J. Fitzgerald, D. Jaffray, Jinzi Zheng, 2015, EJNMMI Research.

261 Lesion characterization with ferumoxytol MRI in patients with advanced solid tumors and correlation with treatment response to MM-398, nanoliposomal irinotecan (nal-IRI)

R. Korn, N. Raghunand, J. Fitzgerald, 2014 .

Abstract 2065: Magnetic resonance imaging with an iron oxide nanoparticle demonstrates the preclinical feasibility of predicting intratumoral uptake and activity of MM-398, a nanoliposomal irinotecan (nal-IRI)

U. Nielsen, J. Fitzgerald, W. Kamoun, 2014 .

Shear- and Compression-induced Chondrocyte Transcription Requires MAPK Activation in Cartilage Explants*

A. Grodzinsky, J. Fitzgerald, M. Jin, 2008, Journal of Biological Chemistry.

Shear and Compression Differentially Regulate Clusters of Functionally Related Temporal Transcription Patterns in Cartilage Tissue*

Moonsoo Jin, Alan J Grodzinsky, A. Grodzinsky, 2006, Journal of Biological Chemistry.

Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel

M. Burkard, J. Fitzgerald, Lauren M. Zasadil, 2021, Science Translational Medicine.

Enhanced Targeting of the EGFR Network with MM-151, an Oligoclonal Anti-EGFR Antibody Therapeutic

U. Nielsen, J. Fitzgerald, O. Burenkova, 2015, Molecular Cancer Therapeutics.

Systems biology driving drug development: from design to the clinical testing of the anti-ErbB3 antibody seribantumab (MM-121)

V. Grantcharova, B. Schoeberl, U. Nielsen, 2017, npj Systems Biology and Applications.

Preclinical activity of nanoliposomal irinotecan is governed by tumor deposition and intratumor prodrug conversion.

U. Nielsen, J. Fitzgerald, D. Drummond, 2014, Cancer research.

Title: Preclinical Activity of Nanoliposomal Irinotecan Is Governed by Tumor Deposition and Intratumor Pro-drug Conversion

U. Nielsen, J. Fitzgerald, D. Drummond, 2014 .

Activity of MM-398, Nanoliposomal Irinotecan (nal-IRI), in Ewing's Family Tumor Xenografts Is Associated with High Exposure of Tumor to Drug and High SLFN11 Expression

T. Triche, J. Fitzgerald, D. Drummond, 2015, Clinical Cancer Research.

Correlation between Ferumoxytol Uptake in Tumor Lesions by MRI and Response to Nanoliposomal Irinotecan in Patients with Advanced Solid Tumors: A Pilot Study

R. Korn, B. Hendriks, N. Raghunand, 2017, Clinical Cancer Research.

Deposition characteristics and resulting DNA damage patterns of liposomal irinotecan (nal-IRI) in pancreatic cancer xenografts.

B. Hendriks, J. Fitzgerald, Helen Lee, 2018 .

Rational engineering of antibody therapeutics targeting multiple oncogene pathways

J. Fitzgerald, A. Lugovskoy, 2011, mAbs.

Preclinical Activity of MM-398 , Nanoliposomal Irinotecan ( nal-IRI ) , in Ewing ' s Family Tumor Xenografts Is Associated with High Exposure of Tumor to Drug and High SLFN 11 Expression

T. Triche, J. Fitzgerald, D. Drummond, 2015 .

Mechanical Compression of Cartilage Explants Induces Multiple Time-dependent Gene Expression Patterns and Involves Intracellular Calcium and Cyclic AMP*

A. Grodzinsky, J. Fitzgerald, D. Wood, 2004, Journal of Biological Chemistry.

Cartilage mechanobiology: the response of chondrocytes to mechanical force

A. Grodzinsky, J. Fitzgerald, C. Wheeler, 2005 .

Comparing routes of delivery for nanoliposomal irinotecan shows superior anti-tumor activity of local administration in treating intracranial glioblastoma xenografts.

M. Berger, M. Prados, C. James, 2013, Neuro-oncology.

Mechanical injury of cartilage explants causes specific time-dependent changes in chondrocyte gene expression.

A. Grodzinsky, J. Fitzgerald, M. Dimicco, 2005, Arthritis and rheumatism.

Liposomal Irinotecan Achieves Significant Survival and Tumor Burden Control in a Triple Negative Breast Cancer Model of Spontaneous Metastasis.

B. Hendriks, J. Fitzgerald, Helen Lee, 2018, Molecular pharmaceutics.

Longitudinal PET Imaging to Monitor Treatment Efficacy by Liposomal Irinotecan in Orthotopic Patient-Derived Pancreatic Tumor Models of High and Low Hypoxia

B. Hendriks, J. Fitzgerald, Helen Lee, 2019, Molecular Imaging and Biology.

Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery.

Brian W. Pogue, Tayyaba Hasan, Stephen P. Pereira, 2018, Cancer research.

Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.

A. Grodzinsky, J. Fitzgerald, A. Plaas, 2009, Archives of biochemistry and biophysics.

Abstract 2719: MM-141, a novel bispecific antibody co-targeting IGF-1R and ErbB3, blocks ligand-induced signaling and demonstrates antitumor activity

B. Schoeberl, U. Nielsen, J. Fitzgerald, 2012 .