J. Ghersi-Egea

发表

Organotypic rat brain culture as in vivo-like model system

S. Fennrich, H. Stier, K. Föhr, 1996 .

Brain barrier systems: a new frontier in metal neurotoxicological research.

Wei Zheng, Michael Aschner, J. Ghersi-Egea, 2003, Toxicology and applied pharmacology.

Efflux transporters in blood-brain interfaces of the developing brain

J. Ghersi-Egea, N. Strazielle, 2015, Front. Neurosci..

Blood-brain interfaces and cerebral drug bioavailability.

J. Ghersi-Egea, J. Honnorat, M. Fèvre-Montange, 2009, Revue neurologique.

Factors affecting delivery of antiviral drugs to the brain

J. Ghersi-Egea, N. Strazielle, Nathalie Strazielle, 2005, Reviews in medical virology.

Detoxification systems, passive and specific transport for drugs at the blood-CSF barrier in normal and pathological situations.

J. Ghersi-Egea, N. Strazielle, S. Khuth, 2004, Advanced drug delivery reviews.

A new aspect of the protective functions of the blood-brain barrier: activities of four drug-metabolizing enzymes in isolated rat brain microvessels.

G. Siest, J. Ghersi-Egea, A. Minn, 1988, Life sciences.

Brain Protection at the Blood–Cerebrospinal Fluid Interface Involves a Glutathione-Dependent Metabolic Barrier Mechanism

J. Ghersi-Egea, A. Jouvet, M. Belin, 2006, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Distribution of cytochrome P450 activities towards alkoxyresorufin derivatives in rat brain regions, subcellular fractions and isolated cerebral microvessels.

G. Siest, J. Ghersi-Egea, A. Minn, 1990, Biochemical pharmacology.

Drug metabolizing enzymes in the brain and cerebral microvessels

G. Siest, J. Ghersi-Egea, A. Minn, 1991, Brain Research Reviews.

In Vitro Models of the Blood–Cerebrospinal Fluid Barrier and Their Use in Neurotoxicological Research

J. Ghersi-Egea, N. Strazielle, 2011 .

Vascular network expansion, integrity of blood–brain interfaces, and cerebrospinal fluid cytokine concentration during postnatal development in the normal and jaundiced rat

J. Ghersi-Egea, C. Tiribelli, L. Guibaud, 2022, Fluids and barriers of the CNS.

Complexity and developmental changes in the expression pattern of claudins at the blood–CSF barrier

J. Ghersi-Egea, A. Vasiljevic, N. Saunders, 2012, Histochemistry and Cell Biology.

Drug Metabolism at the Blood–Brain and Blood–CSF Barriers

J. Ghersi-Egea, X. Declèves, J. Scherrmann, 2014 .

Differential expression of the multidrug resistance‐related proteins ABCb1 and ABCc1 between blood‐brain interfaces

J. Ghersi-Egea, J. Ostrow, C. Tiribelli, 2008, The Journal of comparative neurology.

Glutathione Conjugation at the Blood–CSF Barrier Efficiently Prevents Exposure of the Developing Brain Fluid Environment to Blood-Borne Reactive Electrophilic Substances

J. Ghersi-Egea, N. Strazielle, K. Mönkkönen, 2018, The Journal of Neuroscience.

Barriers to Drug Distribution into the Perinatal and Postnatal Brain

J. Ghersi-Egea, N. Strazielle, Élodie Saudrais, 2018, Pharmaceutical Research.

Prostaglandin E2 metabolism in rat brain: Role of the blood-brain interfaces

J. Ghersi-Egea, N. Strazielle, C. Schmitt, 2008, Cerebrospinal Fluid Research.

Uridine diphosphate-glucuronosyltransferase activities in rat brain microsomes

J. Ghersi-Egea, A. Minn, J. Ghersi-Egea, 1993, Neuroscience Letters.

Inducibility of rat brain drug-metabolizing enzymes

G. Siest, J. Ghersi-Egea, B. Walther, 1987, European Journal of Drug Metabolism and Pharmacokinetics.

Ethoxyresorufin O-deethylase activity in rat brain subcellular fractions

G. Siest, J. Ghersi-Egea, B. Walther, 1987, Neuroscience Letters.

Quantitative measurement of cerebral cytochrome P-450 by second derivative spectrophotometry

G. Siest, J. Ghersi-Egea, B. Walther, 1987, Journal of Neuroscience Methods.

Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease

J. Ghersi-Egea, B. Engelhardt, V. Silva-Vargas, 2018, Acta Neuropathologica.

A Simple Method for Evaluation of Superoxide Radical Production in Neural Cells under Various Culture Conditions: Application to Hypoxia

J. Ghersi-Egea, V. Koziel, J. Daval, 1995, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Are blood-brain interfaces efficient in protecting the brain from reactive molecules?

J. Ghersi-Egea, M. Belin, N. Strazielle, 2001, Advances in experimental medicine and biology.

Neuroprotective and Detoxifying Mechanisms at the Blood-Brain Interfaces

J. Ghersi-Egea, M. Belin, N. Strazielle, 2001 .

Choroid Plexus Transporters for Drugs and Other Xenobiotics

J. Ghersi-Egea, N. Strazielle, 2002, Journal of drug targeting.

Cimetidine inhibits cerebral and hepatic mitochondrial respiration in rat.

J. Ghersi-Egea, B. Walther, A. Minn, 1986, Toxicology letters.

Choroid plexus glutathione peroxidases are instrumental in protecting the brain fluid environment from hydroperoxides during postnatal development.

J. Ghersi-Egea, N. Strazielle, Élodie Saudrais, 2018, American journal of physiology. Cell physiology.

The rapid flow of cerebrospinal fluid from ventricles to cisterns via subarachnoid velae in the normal rat.

J. Ghersi-Egea, J. Fenstermacher, W. Finnegan, 1997, Acta neurochirurgica. Supplement.

Brain leukocyte infiltration initiated by peripheral inflammation or experimental autoimmune encephalomyelitis occurs through pathways connected to the CSF-filled compartments of the forebrain and midbrain

J. Ghersi-Egea, N. Strazielle, C. Schmitt, 2012, Journal of Neuroinflammation.

Pro‐Inflammatory Cytokines Modulate Matrix Metalloproteinase Secretion and Organic Anion Transport at the Blood‐Cerebrospinal Fluid Barrier

J. Ghersi-Egea, M. Belin, P. Giraudon, 2003, Journal of neuropathology and experimental neurology.

T-Lymphocytes Traffic into the Brain across the Blood-CSF Barrier: Evidence Using a Reconstituted Choroid Plexus Epithelium

J. Ghersi-Egea, C. Malcus, N. Strazielle, 2016, PloS one.

N-acetylcysteine inhibits bacterial lipopeptide-mediated neutrophil transmigration through the choroid plexus in the developing brain

J. Ghersi-Egea, H. Hagberg, C. Mallard, 2020, Acta Neuropathologica Communications.

Toxic shock syndrome toxin-1 challenges the neuroprotective functions of the choroidal epithelium and induces neurotoxicity.

J. Ghersi-Egea, F. Vandenesch, G. Lina, 2006, The Journal of infectious diseases.

Drug metabolism in in vitro organotypic and cellular models of mammalian central nervous system: activities of membrane-bound epoxide hydrolase and NADPH-cytochrome P-450 (c) reductase.

S. Fennrich, J. Ghersi-Egea, B. Schlosshauer, 1998, Neurotoxicology.

A simple novel approach for detecting blood–brain barrier permeability using GPCR internalization

S. Lehéricy, M. Tanter, T. Vitalis, 2020, Neuropathology and applied neurobiology.

Posttraumatic Invasion of Monocytes across the Blood—Cerebrospinal Fluid Barrier

J. Ghersi-Egea, J. Szmydynger-Chodobska, A. Chodobski, 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Changes in the cerebrospinal fluid circulatory system of the developing rat: quantitative volumetric analysis and effect on blood-CSF permeability interpretation

J. Ghersi-Egea, N. Strazielle, Sandrine Blondel, 2015, Fluids and Barriers of the CNS.

New diketopiperazines as vectors for peptide protection and brain delivery: Synthesis and biological evaluation.

J. Ghersi-Egea, P. Perret, S. Chierici, 2016, Journal of labelled compounds & radiopharmaceuticals.

Rat choroid plexuses contain myeloid progenitors capable of differentiation toward macrophage or dendritic cell phenotypes

J. Ghersi-Egea, S. Nataf, M. Belin, 2006, Glia.

Purified IgG from aquaporin-4 neuromyelitis optica spectrum disorder patients alters blood-brain barrier permeability

J. Ghersi-Egea, P. Giraudon, R. Marignier, 2019, PloS one.

Cerebral concentration and toxicity of endocrine disrupting chemicals: The implication of blood-brain interfaces.

J. Ghersi-Egea, A. Denuzière, 2022, Neurotoxicology.

Complexity and developmental changes in the expression pattern of claudins at the blood–CSF barrier

J. Ghersi-Egea, A. Vasiljevic, M. Fèvre-Montange, 2012, Histochemistry and Cell Biology.

Histopathologic and Ultrastructural Features and Claudin Expression in Papillary Tumors of the Pineal Region: A Multicenter Analysis

P. Varlet, J. Ghersi-Egea, A. Jouvet, 2012, The American journal of surgical pathology.

Nicotine Raises the Influx of Permeable Solutes across the Rat Blood—Brain Barrier with Little or No Capillary Recruitment

C. Patlak, J. Ghersi-Egea, L. Wei, 1995, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Severe neonatal hyperbilirubinemia and the brain: the old but still evolving story

J. Ghersi-Egea, C. Tiribelli, S. Gazzin, 2021, Pediatric Medicine.

The Role of the Choroid Plexus in Neutrophil Invasion after Traumatic Brain Injury

J. Ghersi-Egea, J. Szmydynger-Chodobska, A. Chodobski, 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Novel routes to either racemic or enantiopure α-amino-(4-hydroxy-pyrrolidin-3-yl)acetic acid derivatives and biological evaluation of a new promising pharmacological scaffold.

J. Ghersi-Egea, L. Denoroy, S. Parrot, 2015, European journal of medicinal chemistry.

A marked enhancement of a BLOC‐1 gene, pallidin, associated with somnolent mouse models deficient in histamine transmission

J. Ghersi-Egea, Jian-Sheng Lin, L. Seugnet, 2022, bioRxiv.

Brain mitochondrial cytochrome P-450scc: spectral and catalytic properties.

G. Siest, J. Ghersi-Egea, B. Walther, 1987, Archives of biochemistry and biophysics.

Choroid plexus controls brain availability of anti-HIV nucleoside analogs via pharmacologically inhibitable organic anion transporters

J. Ghersi-Egea, M. Belin, N. Strazielle, 2003, AIDS.

Potential Pathways for CNS Drug Delivery Across the Blood-Cerebrospinal Fluid Barrier

J. Ghersi-Egea, N. Strazielle, 2016, Current pharmaceutical design.

Electronic spin resonance detection of superoxide and hydroxyl radicals during the reductive metabolism of drugs by rat brain preparations and isolated cerebral microvessels.

J. Ghersi-Egea, V. Maupoil, L. Rochette, 1998, Free radical biology & medicine.

Enzyme mediated superoxide radical formation initiated by exogenous molecules in rat brain preparations.

G. Siest, J. Ghersi-Egea, A. Minn, 1991, Toxicology and applied pharmacology.

Induction and immunological characterization of the uridine diphosphate-glucuronosyltransferase conjugating 1-naphthol in the rat choroid plexus

G. Siest, J. Ghersi-Egea, A. Minn, 1994, Neuroscience Letters.

Changes of cerebral gamma glutamyltransferase activities after treatment with exogenous inducers

G. Siest, J. Ghersi-Egea, A. Minn, 1987, Neurochemical Research.

The Choroid Plexus and Cerebrospinal Fluid System: Roles in Neurodegenerative Diseases

J. Ghersi-Egea, J. Badaut, 2016 .

Choroid Plexus in the Central Nervous System: Biology and Physiopathology

J. Ghersi-Egea, N. Strazielle, J. Ghersi-Egea, 2000, Journal of neuropathology and experimental neurology.

The quest for a better insight into physiology of fluids and barriers of the brain: the exemplary career of Joseph D. Fenstermacher

C. Nicholson, J. Ghersi-Egea, J. Szmydynger-Chodobska, 2015, Fluids and Barriers of the CNS.

The Dependency of Influx Across the Blood-Brain Barrier on Blood Flow and the Apparent Flow-Independence of Glucose Influx During Stress

Ling Wei, C. Patlak, J. Ghersi-Egea, 1995 .

Developmental changes in the transcriptome of the rat choroid plexus in relation to neuroprotection

J. Ghersi-Egea, S. Liddelow, N. Saunders, 2013, Fluids and Barriers of the CNS.

Metabolism: A Bottleneck in In Vitro Toxicological Test Development

Andrew Worth, Silvia Casati, Raffaella Corvi, 2006, Alternatives to laboratory animals : ATLA.

Developmental differences in the expression of ABC transporters at rat brain barrier interfaces following chronic exposure to diallyl sulfide

J. Ghersi-Egea, N. Saunders, K. Møllgård, 2019, Scientific Reports.

P‐glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Localize in the Microvessels Forming the Blood‐Tumor Barrier in Ependymomas

J. Ghersi-Egea, A. Jouvet, M. Fèvre-Montange, 2010, Brain pathology.

Subcellular distribution of cytochrome P-450 in the brain

G. Siest, J. Ghersi-Egea, B. Walther, 1986, Brain Research.

Subcellular localization of cytochrome P450, and activities of several enzymes responsible for drug metabolism in the human brain.

G. Siest, J. Ghersi-Egea, G. Cuny, 1993, Biochemical pharmacology.

Chapter 49: Drug metabolizing enzymes in the rat pituitary gland

G. Siest, J. Ghersi-Egea, A. Minn, 1992 .

Blood-brain interfaces: relevance to cerebral drug metabolism.

J. Ghersi-Egea, J. Fenstermacher, B. Leininger-Muller, 1995, Toxicology letters.

Evidence for drug metabolism as a source of reactive species in the brain.

J. Ghersi-Egea, M. Livertoux, 1992, EXS.

Neuroprotective Mechanisms at the Blood-CSF Barrier of the Developing and Adult Brain

J. Ghersi-Egea, A. Vasiljevic, N. Strazielle, 2020 .

Transport and Metabolism at Blood–Brain Interfaces and in Neural Cells: Relevance to Bilirubin-Induced Encephalopathy

J. Ghersi-Egea, C. Tiribelli, S. Gazzin, 2012, Front. Pharmacol..

Modulation of Mrp1 (ABCc1) and Pgp (ABCb1) by Bilirubin at the Blood-CSF and Blood-Brain Barriers in the Gunn Rat

R. Wennberg, J. Ghersi-Egea, J. Ostrow, 2011, PloS one.

Brain drug delivery, drug metabolism, and multidrug resistance at the choroid plexus

J. Ghersi-Egea, N. Strazielle, J F Ghersi-Egea, 2001, Microscopy research and technique.

In Vivo Study of the Elimination from Rat Brain of an Intracerebrally Formed Xenobiotic Metabolite, 1‐Naphthyl‐β‐D‐Glucuronide

G. Siest, J. Ghersi-Egea, A. Minn, 1991, Journal of neurochemistry.

Drug metabolizing enzymes in the rat pituitary gland.

G. Siest, J. Ghersi-Egea, A. Minn, 1992, Progress in brain research.

Active transport at the blood‐CSF barrier contributes to manganese influx into the brain

J. Ghersi-Egea, P. Richaud, Alexandre Bouron, 2011, Journal of neurochemistry.

Demonstration of a Coupled Metabolism–Efflux Process at the Choroid Plexus as a Mechanism of Brain Protection Toward Xenobiotics

J. Ghersi-Egea, N. Strazielle, 1999, The Journal of Neuroscience.

Blood-brain barrier dysfunction in disorders of the developing brain

J. Ghersi-Egea, P. Gressens, G. Damante, 2015, Front. Neurosci..

The legacy of Malcolm Beverley Segal (1937–2019) on the science and fields concerned with choroid plexus and cerebrospinal fluid physiology

J. Ghersi-Egea, J. Szmydynger-Chodobska, A. Chodobski, 2019, Fluids and Barriers of the CNS.

In Vitro Evidence That β‐Amyloid Peptide 1–40 Diffuses Across the Blood–Brain Barrier and Affects Its Permeability

C. Patlak, J. Ghersi-Egea, M. Dehouck, 2000, Journal of neuropathology and experimental neurology.

Mechanisms That Determine the Internal Environment of the Developing Brain: A Transcriptomic, Functional and Ultrastructural Approach

J. Ghersi-Egea, Helen Lindsay, M. Wakefield, 2013, PloS one.

Molecular characterization of circumventricular organs and third ventricle ependyma in the rat: potential markers for periventricular tumors

J. Ghersi-Egea, A. Jouvet, A. Wierinckx, 2013, Neuropathology : official journal of the Japanese Society of Neuropathology.

Clinical Imaging of Choroid Plexus in Health and in Brain Disorders: A Mini-Review

J. Ghersi-Egea, M. Wiart, F. Chauveau, 2019, Front. Mol. Neurosci..

Blood–Brain Interfaces Organization in Relation to Inorganic Ion Transport, CSF Secretion, and Circulation

J. Ghersi-Egea, Helle H Damkier, H. Damkier, 2017 .

[Biological roles of trace elements in the brain with special focus on Zn and Fe].

J. Ghersi-Egea, S. Bohic, J. Gibon, 2011, Revue neurologique.

Influx mechanisms in the embryonic and adult rat choroid plexus: a transcriptome study

J. Ghersi-Egea, Helen Lindsay, M. Wakefield, 2015, Front. Neurosci..

The legacy of Malcolm Beverley Segal (1937–2019) on the science and fields concerned with choroid plexus and cerebrospinal fluid physiology

J. Ghersi-Egea, R. Thorne, J. Szmydynger-Chodobska, 2019, Fluids and Barriers of the CNS.

Impairment of blood–cerebrospinal fluid barrier properties by retrovirus‐activated T lymphocytes: reduction in cerebrospinal fluid‐to‐blood efflux of prostaglandin E2

J. Ghersi-Egea, M. Belin, P. Giraudon, 2005, Journal of neurochemistry.

Barriers to Drug Distribution into the Perinatal and Postnatal Brain

J. Ghersi-Egea, N. Strazielle, Elodie Saudrais, 2018, Pharmaceutical Research.

N-acetylcysteine inhibits bacterial lipopeptide-mediated neutrophil transmigration through the choroid plexus in the developing brain

J. Ghersi-Egea, H. Hagberg, C. Mallard, 2020, Acta Neuropathologica Communications.

Blood-brain interfaces and bilirubin-induced neurological diseases.

J. Ghersi-Egea, S. Gazzin, N. Strazielle, 2009, Current pharmaceutical design.

Correction: Mechanisms That Determine the Internal Environment of the Developing Brain: A Transcriptomic, Functional and Ultrastructural Approach

J. Ghersi-Egea, Helen Lindsay, M. Wakefield, 2016, PLoS ONE.

Drug transfer in the choroid plexus. Multiplicity and substrate specificities of transporters

Y. Sugiyama, J. Ghersi-Egea, 2004 .

Strategies to advance translational research into brain barriers

J. Nutt, W. Banks, D. Groothuis, 2008, The Lancet Neurology.

Fate of Cerebrospinal Fluid‐Borne Amyloid β‐Peptide: Rapid Clearance into Blood and Appreciable Accumulation by Cerebral Arteries

C. Patlak, J. Ghersi-Egea, J. Ghiso, 1996, Journal of neurochemistry.

Physiology of blood-brain interfaces in relation to brain disposition of small compounds and macromolecules.

J. Ghersi-Egea, N. Strazielle, N Strazielle, 2013, Molecular pharmaceutics.

Localization of Drug‐Metabolizing Enzyme Activities to Blood‐Brain Interfaces and Circumventricular Organs

G. Siest, J. Ghersi-Egea, A. Minn, 1994, Journal of neurochemistry.

Brain Barrier Systems Play No Small Roles in Toxicant-Induced Brain Disorders.

J. Ghersi-Egea, Wei Zheng, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Differential expression of the multidrug resistance‐related proteins ABCb1 and ABCc1 between blood‐brain interfaces

J. Ghersi-Egea, J. Ostrow, C. Tiribelli, 2008, The Journal of comparative neurology.

Rapid distribution of intraventricularly administered sucrose into cerebrospinal fluid cisterns via subarachnoid velae in rat

J. Ghersi-Egea, J. Fenstermacher, J. Ghersi-Egea, 1996, Neuroscience.

J. Ghersi-Egea, N. Strazielle, C. Schmitt, 2012, Journal of Neuroinflammation.

NADPH:cytochrome P-450(c) reductase: Biochemical characterization in rat brain and cultured neurons and evolution of activity during development

G. Siest, J. Ghersi-Egea, Z. Jayyosi, 1989, Neurochemical Research.

The activity of 1-naphthol-UDP-glucuronosyltransferase in the brain

G. Siest, J. Ghersi-Egea, B. Walther, 1987, Neuropharmacology.

Histopathologic and Ultrastructural Features and Claudin Expression in Papillary Tumors of the Pineal Region: A Multicenter Analysis

P. Varlet, J. Ghersi-Egea, A. Jouvet, 2012, The American journal of surgical pathology.

Blood–brain borders: a proposal to address limitations of historical blood–brain barrier terminology

J. Ghersi-Egea, J. Konsman, Jerome Badaut, 2024, Fluids and barriers of the CNS.