D. Kassel

发表

Combinatonial chemistry and mass spectrometry in the 21st century drug discovery laboratory.

D. Kassel, 2001, Chemical reviews.

Combinatorial Chemistry and Mass Spectrometry in the 21st Century Drug Discovery Laboratory

D. Kassel, 2001 .

Improvement of "hit-to-lead" optimization by integration of in vitro HTS experimental models for early determination of pharmacokinetic properties.

I. Kariv, D. Kassel, R. Rourick, 2002, Combinatorial chemistry & high throughput screening.

Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors.

D. Kassel, S. L. Gwaltney, Lihong Shi, 2008, Bioorganic & medicinal chemistry letters.

Characterization of the peptide substrate specificities of interstitial collagenase and 92-kDa gelatinase. Implications for substrate optimization.

D. Kassel, M. Green, J. Wiseman, 1994, The Journal of biological chemistry.

Design and synthesis of pyrimidinone and pyrimidinedione inhibitors of dipeptidyl peptidase IV.

D. Kassel, S. L. Gwaltney, K. Aertgeerts, 2011, Journal of medicinal chemistry.

High-Throughput Purification

D. Kassel, 2007 .

Primary structure determination of peptides and enzymatically digested proteins using capillary liquid chromatography/mass spectrometry and rapid linked-scan techniques.

D. Kassel, B. Musselman, J. A. Smith, 1991, Analytical chemistry.

In vitro phosphorylation of the epidermal growth factor receptor autophosphorylation domain by c-src: identification of phosphorylation sites and c-src SH2 domain binding sites.

D. Kassel, T. Consler, C. Lombardo, 1995, Biochemistry.

Two-dimensional supercritical fluid chromatography/mass spectrometry for the enantiomeric analysis and purification of pharmaceutical samples.

Yinong Zhang, Rongda Xu, D. Kassel, 2011, Journal of chromatography. A.

Parallel SFC/MS-MUX screening to assess enantiomeric purity.

D. Kassel, L. Zeng, Derek B Laskar, 2008, Chirality.

Automated analytical/preparative high-performance liquid chromatography–mass spectrometry system for the rapid characterization and purification of compound libraries

B. Shushan, D. Kassel, L. Zeng, 1998 .

Mass-directed fractionation and isolation of pharmaceutical compounds by packed-column supercritical fluid chromatography/mass spectrometry.

D. Kassel, M. Barber, Ingo H. Hardt, 2001, Rapid communications in mass spectrometry : RCM.

Characterization of pp60c-src tyrosine kinase activities using a continuous assay: autoactivation of the enzyme is an intermolecular autophosphorylation process.

D. Kassel, X. Huang, D. Weigl, 1995, Biochemistry.

Development of a High-Throughput Online Solid-Phase Extraction/Tandem Mass Spectrometry Method for Cytochrome P450 Inhibition Screening

D. Kassel, Can C. Özbal, K. B. Lim, 2010, Journal of biomolecular screening.

Correlation of the phosphorylation states of pp60c-src with tyrosine kinase activity: the intramolecular pY530-SH2 complex retains significant activity if Y419 is phosphorylated.

D. Kassel, S. C. Barker, W. Knight, 1996, Biochemistry.

Optimization of the fragmentation in a frit-fast atom bombardment ion source for the sequencing of peptides at the picomole level.

D. Kassel, J. Smith, B. Musselman, 1991, Analytical chemistry.

Differentiation of hydroxyproline isomers and isobars in peptides by tandem mass spectrometry.

K. Biemann, D. Kassel, 1990, Analytical chemistry.

Electrospray ionization mass spectra of hemoglobin and transferrin by a magnetic sector mass spectrometer. Comparison with theoretical isotopic distributions.

Y. Wada, D. Kassel, B. Musselman, 1992, Rapid communications in mass spectrometry : RCM.

RAPID PURIFICATION, SEPARATION AND IDENTIFICATION OF PROTEINS AND ENZYME DIGESTS USING PACKED CAPILLARY PERFUSION COLUMN LC AND LC/MS

D. Kassel, J. Salzmann, D. Willard, 1993 .

Applications of high-throughput ADME in drug discovery.

D. Kassel, Daniel B Kassel, 2004, Current opinion in chemical biology.

Evaluation of packed capillary perfusion column HPLC/MS/MS for the rapid mapping and sequencing of enzymic digests

B. Shushan, D. Kassel, J. Salzmann, 1994 .

Utility and limitations of electron ionization and chemical ionization for the determination of position and extent of labeling for 18O- and 13C-containing permethylated alditols by gas chromatography/mass spectrometry.

D. Kassel, J. Allison, 1986, Analytical chemistry.

Urinary metabolites of L-threonine in type 1 diabetes determined by combined gas chromatography/chemical ionization mass spectrometry.

D. Kassel, C. Sweeley, W. Schall, 1986, Biomedical & environmental mass spectrometry.

Automated high throughput ADME assays for metabolic stability and cytochrome P450 inhibition profiling of combinatorial libraries.

Rongda Xu, D. Kassel, R. Rourick, 2004, Journal of pharmaceutical and biomedical analysis.

for Cytochrome P 450 Inhibition Screening Development of a High-Throughput Online Solid-Phase Extraction / Tandem Mass Spectrometry Method

D. Kassel, Can C. Özbal, K. B. Lim, 2010 .

Studies on the Role of Antigen Processing in T Cell Determinant Selection and Hierarchy

D. Kassel, John A. Smith, K. Williams, 1992 .

Fluorous mixture synthesis of two libraries with hydantoin-, and benzodiazepinedione-fused heterocyclic scaffolds.

Wei Zhang, D. Kassel, L. Zeng, 2006, Journal of combinatorial chemistry.

Realities of high-throughput liquid chromatography/mass spectrometry purification of large combinatorial libraries: a report on overall sample throughput using parallel purification.

D. Kassel, J. Isbell, R. Xu, 2002, Journal of combinatorial chemistry.

Catalytic activity of the SH2 domain of human pp60c-src; evidence from NMR, mass spectrometry, site-directed mutagenesis and kinetic studies for an inherent phosphatase activity.

D. G. Davis, D. Kassel, F. Loganzo, 1995, Biochemistry.

Identification of in Vitro Phosphorylation Sites in the Growth Cone Protein SCG10

D. Kassel, G. Di Paolo, B. Riederer, 1998, The Journal of Biological Chemistry.

Mass spectrometric analysis of cardiac glycosides by the desorption/ionization technique potassium ion ionization of desorbed species.

D. Kassel, J. Allison, K. Light, 1989, Biomedical & environmental mass spectrometry.

Utility of ion source pretreatment with chlorine-containing compounds for enhanced performance in gas chromatography/negative ionization mass spectrometry.

D. Kassel, J. Watson, J. Allison, 1988, Analytical chemistry.

Identification of phosphorylated peptides from complex mixtures using negative-ion orifice-potential stepping and capillary liquid chromatography/electrospray ionization mass spectrometry.

D. Kassel, W. Burkhart, J. Ding, 1994, Rapid communications in mass spectrometry : RCM.

Potassium ion ionization of desorbed species (K+IDS): a rapid method for the screening of urine for organic acidemias.

D. Kassel, J. Allison, 1988, Biomedical & environmental mass spectrometry.

Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation*

E. Chien, D. Kassel, D. McRee, 2003, Journal of Biological Chemistry.

Chapter 27. Existing and emerging strategies for the analytical characterization and profiling of compound libraries

D. Kassel, G. Nemeth, 2001 .

Developments of a fully automated parallel HPLC/mass spectrometry system for the analytical characterization and preparative purification of combinatorial libraries

D. Kassel, Lu Zeng, L. Zeng, 1998 .

A new ultra‐high throughput method for characterizing combinatorial libraries incorporating a multiple probe autosampler coupled with flow injection mass spectrometry analysis

D. Kassel, L. Burton, L. Zeng, 1998 .

Parallel supercritical fluid chromatography/mass spectrometry system for high-throughput enantioselective optimization and separation.

Rongda Xu, D. Kassel, Lu Zeng, 2007, Journal of chromatography. A.

Fragmentation of tunichrome Sp-1 is dominated by an unusual gas-phase intramolecular rearrangement.

Steven W. Taylor, D. Kassel, A. Craig, 2003, Journal of Mass Spectrometry.

A VERSATILE MECHANISM BASED REACTION PROBE FOR THE DIRECT SELECTION OF BIOCATALYSTS

F. Raushel, D. Kassel, K. Janda, 1996 .

Direct coupling of an automated 2-dimensional microcolumn affinity chromatography-capillary HPLC system with mass spectrometry for biomolecule analysis

D. Kassel, T. Consler, M. Shalaby, 1995 .

Application of parallel liquid chromatography/mass spectrometry for high throughput microsomal stability screening of compound libraries

Csaba Nemes, Rongda Xu, Charles C. Liu, 2002, Journal of the American Society for Mass Spectrometry.

Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys.

D. Kassel, K. Takeuchi, Lihong Shi, 2008, European journal of pharmacology.

Phosphopeptides enrichment using on-line two-dimensional strong cation exchange followed by reversed-phase liquid chromatography/mass spectrometry.

D. Kassel, K. B. Lim, 2006, Analytical biochemistry.

Purification, characterization, and in vitro phosphorylation of the neuron-specific membrane-associated protein SCG10.

D. Kassel, B. Antonsson, G. Di Paolo, 1997, Protein expression and purification.

In Vitro ADME Profiling and Pharmacokinetic Screening in Drug Discovery

D. Kassel, 2012 .

Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV.

D. Kassel, S. L. Gwaltney, K. Takeuchi, 2007, Journal of medicinal chemistry.

Exploration of the Sequence Specificity of pp60c-src Tyrosine Kinase

D. Kassel, M. Luther, S. C. Barker, 1995, The Journal of Biological Chemistry.

High-throughput mass-directed parallel purification incorporating a multiplexed single quadrupole mass spectrometer.

D. Kassel, J. Isbell, R. Xu, 2002, Analytical chemistry.

Cell-based assay for screening 11beta-hydroxysteroid dehydrogenase inhibitors using liquid chromatography/tandem mass spectrometry detection.

D. Kassel, Biching Sang, M. Navre, 2006, Rapid communications in mass spectrometry : RCM.

A high throughput metabolic stability screening workflow with automated assessment of data quality in pharmaceutical industry.

D. Kassel, R. Xu, Joshua Cramlett, 2010, Journal of chromatography. A.

Substrate specificity and novel selective inhibitors of TNF-alpha converting enzyme (TACE) from two-dimensional substrate mapping.

M. Lambert, D. Kassel, R. Wiethe, 2005, Combinatorial chemistry & high throughput screening.

Differences in phosphorylation of human and chicken stathmin by MAP kinase

D. Kassel, E. Ruchti, G. Grenningloh, 2001, Journal of cellular biochemistry.

Peptide inhibitors of src SH3-SH2-phosphoprotein interactions.

Larry J. Shampine, Patel, P. Charifson, 1995, The Journal of biological chemistry.

Phosphorylation of a cAMP-specific phosphodiesterase (HSPDE4B2B) by mitogen-activated protein kinase.

D. Kassel, W. Rocque, W. Holmes, 1996, The Biochemical journal.

A multiple electrospray interface for parallel mass spectrometric analyses of compound libraries.

D. Kassel, L. Zeng, D B Kassel, 1999, Combinatorial chemistry & high throughput screening.