V. Felipo

V. Felipo, A. Pellicer, B. Pellicer, 2011, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

The PHES battery does not detect all cirrhotic patients with early neurological deficits, which are different in different patients

V. Felipo, C. Montoliu, D. Escudero-García, 2017, PloS one.

Hypolocomotion in rats with chronic liver failure is due to increased glutamate and activation of metabotropic glutamate receptors in substantia nigra.

V. Felipo, S. Erceg, M. Llansola, 2007, Journal of hepatology.

The Dual Role of the GABAA Receptor in Peripheral Inflammation and Neuroinflammation: A Study in Hyperammonemic Rats

V. Felipo, M. Malaguarnera, M. Llansola, 2021, International journal of molecular sciences.

The function of the glutamate-nitric oxide-cGMP pathway in brain in vivo and learning ability decrease in parallel in mature compared with young rats.

V. Felipo, C. Montoliu, O. Cauli, 2007, Learning & memory.

Role of extracellular cGMP and of hyperammonemia in the impairment of learning in rats with chronic hepatic failure Therapeutic implications

V. Felipo, C. Montoliu, S. Erceg, 2006, Neurochemistry International.

Cirrhosis, Hyperammonemia, and Hepatic Encephalopathy

V. Felipo, S. Grisolía, 1993, Advances in Experimental Medicine and Biology.

Potentiation of the Transient Receptor Potential Vanilloid 1 Channel Contributes to Pruritogenesis in a Rat Model of Liver Disease*

V. Felipo, C. Montoliu, A. Ferrer-Montiel, 2013, The Journal of Biological Chemistry.

39th Annual European Brain and Behaviour Society Abstracts

Maria V. Sanchez-Vives, R. C. Honey, J. L. Moore, 2007, Neural Plasticity.

Trialkylglycines: a new family of compounds with in vivo neuroprotective activity.

V. Felipo, C. Montoliu, A. Sánchez-Pérez, 2006, CNS drug reviews.

Serum nitrotyrosine and psychometric tests as indicators of impaired fitness to drive in cirrhotic patients with minimal hepatic encephalopathy

V. Felipo, C. Montoliu, A. Urios, 2013, Liver international : official journal of the International Association for the Study of the Liver.

Determination of selected neurotoxic insecticides in small amounts of animal tissue utilizing a newly constructed mini-extractor

V. Felipo, A. Kočan, M. Llansola, 2017, Analytical and Bioanalytical Chemistry.

Learning and Memory Impairments in Patients with Minimal Hepatic Encephalopathy are Associated with Structural and Functional Connectivity Alterations in Hippocampus

C. Forn, C. Ávila, V. Felipo, 2018, Scientific Reports.

Reduced resting state connectivity and gray matter volume correlate with cognitive impairment in minimal hepatic encephalopathy

C. Forn, C. Ávila, V. Felipo, 2017, PloS one.

Altered postural control and stability in cirrhotic patients with minimal hepatic encephalopathy correlate with cognitive deficits

E. Noé, V. Felipo, C. Montoliu, 2017, Liver international : official journal of the International Association for the Study of the Liver.

Alterations in adipocytokines and cGMP homeostasis in morbid obesity patients reverse after bariatric surgery

V. Felipo, C. Montoliu, A. Urios, 2013, Obesity.

Expression and traffic of cellular prolyl oligopeptidase are regulated during cerebellar granule cell differentiation, maturation, and aging

V. Felipo, P. Männistö, J. Garcia-horsman, 2008, Neuroscience.

β-Amyloid-induced activation of Caspase-3 in primary cultures of rat neurons

V. Felipo, F. J. Romero, F. Bosch-Morell, 2000, Mechanisms of Ageing and Development.

Minimal hepatic encephalopathy is associated with expansion and activation of CD4+CD28−, Th22 and Tfh and B lymphocytes

V. Felipo, C. Montoliu, D. Escudero-García, 2017, Scientific Reports.

Hepatic encephalopathy

S. Taylor-Robinson, R. Dhiman, V. Felipo, 2022, Nature Reviews Disease Primers.

Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-κB pathway

V. Felipo, J. Forteza, C. Montoliu, 2020, Journal of Neuroinflammation.

The S1PR2‐CCL2‐BDNF‐TrkB pathway mediates neuroinflammation and motor incoordination in hyperammonaemia

V. Felipo, M. Llansola, Tiziano Balzano, 2022, Neuropathology and applied neurobiology.

Changes in liver and plasma acetylcholinesterase in rats with cirrhosis induced by bile duct ligation

V. Felipo, R. Jover, J. Clària, 2006, Hepatology.

Cirrhotic patients with minimal hepatic encephalopathy have increased capacity to eliminate superoxide and peroxynitrite in lymphocytes, associated with cognitive impairment

V. Felipo, E. Kosenko, C. Montoliu, 2018, Free radical research.

Glutamate Induces a Calcineurin‐Mediated Dephosphorylation of Na+,K+‐ATPase that Results in Its Activation in Cerebellar Neurons in Culture

G. Marcaida, V. Felipo, M. Miñana, 1996, Journal of neurochemistry.

Blockade of nitric oxide signalling promotes resilience to the effects of social defeat stress on the conditioned rewarding properties of MDMA in mice.

V. Felipo, M. Llansola, M. Aguilar, 2020, Nitric oxide : biology and chemistry.

Chronic hyperammonemia reduces the activity of neuronal nitric oxide synthase in cerebellum by altering its localization and increasing its phosphorylation by calcium‐calmodulin kinase II

V. Felipo, O. Cauli, R. Rodrigo, 2008, Journal of neurochemistry.

Activation of soluble guanylate cyclase by nitric oxide in lymphocytes correlates with minimal hepatic encephalopathy in cirrhotic patients

V. Felipo, C. Montoliu, M. Serra, 2007, Journal of Molecular Medicine.

Real‐time cytometric assay of nitric oxide and superoxide interaction in peripheral blood monocytes: A no‐wash, no‐lyse kinetic method

V. Felipo, J. O'connor, C. Montoliu, 2017, Cytometry. Part B, Clinical cytometry.

Mutagenicity of nitric oxide-releasing compounds in Escherichia coli: effect of superoxide generation and evidence for two mutagenic mechanisms.

V. Felipo, A. Urios, M. Blanco, 2001, Mutation research.

Proteome analysis of primary neurons and astrocytes from rat cerebellum.

V. Felipo, G. Lubec, Jae-Won Yang, 2005, Journal of proteome research.

Gender differential effects of developmental exposure to methyl-mercury, polychlorinated biphenyls 126 or 153, or its combinations on motor activity and coordination.

V. Felipo, M. Llansola, O. Cauli, 2013, Toxicology.

p38 MAP kinase is a therapeutic target for hepatic encephalopathy in rats with portacaval shunts

V. Felipo, M. Llansola, O. Cauli, 2011, Gut.

Rifaximin Prevents T-Lymphocytes and Macrophages Infiltration in Cerebellum and Restores Motor Incoordination in Rats with Mild Liver Damage

V. Felipo, M. Malaguarnera, M. Llansola, 2021, Biomedicines.

Peripheral inflammation induces neuroinflammation that alters neurotransmission and cognitive and motor function in hepatic encephalopathy: Underlying mechanisms and therapeutic implications

V. Felipo, C. Montoliu, M. Malaguarnera, 2019, Acta physiologica.

The Cerebellum of Patients with Steatohepatitis Shows Lymphocyte Infiltration, Microglial Activation and Loss of Purkinje and Granular Neurons

V. Felipo, J. Forteza, C. Montoliu, 2018, Scientific Reports.

Contribution of hyperammonemia and inflammatory factors to cognitive impairment in minimal hepatic encephalopathy

V. Felipo, C. Montoliu, A. Urios, 2011, Metabolic Brain Disease.

Effect of L-carnitine on postischemic inhibition of protein synthesis in the rat brain.

V. Felipo, C. Montoliu, J. Burda, 2009, General physiology and biophysics.

New Trends in Cancer for the 21st Century

A. Llombart‐Bosch, V. Felipo, J. López-Guerrero, 2003, Advances in Experimental Medicine and Biology.

Experimental models of hepatic encephalopathy: ISHEN guidelines

M. Norenberg, R. Butterworth, V. Felipo, 2009, Liver international : official journal of the International Association for the Study of the Liver.

Nicotine prevents glutamate-induced proteolysis of the microtubule-associated protein MAP-2 and glutamate neurotoxicity in primary cultures of cerebellar neurons

V. Felipo, M. Miñana, S. Grisolía, 1998, Neuropharmacology.

Modulation of GABAA receptors by neurosteroids. A new concept to improve cognitive and motor alterations in hepatic encephalopathy

V. Felipo, C. Montoliu, M. Llansola, 2016, The Journal of Steroid Biochemistry and Molecular Biology.

Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia

V. Felipo, M. Llansola, Tiziano Balzano, 2016, Journal of Neuroinflammation.

Hyperammonemia induces brain tubulin.

V. Felipo, M. Miñana, S. Grisolía, 1990, Advances in experimental medicine and biology.

Prevention of the acute neurotoxic effects of phenytoin on rat peripheral nerve by H7, an inhibitor of protein kinase C.

V. Felipo, C. Hermenegildo, M. Miñana, 1992, Toxicology.

Inhibitors of protein kinase C prevent the toxicity of glutamate in primary neuronal cultures

V. Felipo, S. Grisolía, María-Dolores Min˜ana, 1993, Brain Research.

Blocking glycine receptors reduces neuroinflammation and restores neurotransmission in cerebellum through ADAM17-TNFR1-NF-κβ pathway

V. Felipo, Yaiza M. Arenas, A. Cabrera-Pastor, 2020, Journal of neuroinflammation.

Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats.

V. Felipo, P. López-Larrubia, S. Cerdán, 2011, Gastroenterology.

Increased protein kinase A regulatory subunit content and cGMP binding in erythrocyte membranes in liver cirrhosis.

V. Felipo, E. Kosenko, J. Calvete, 2004, Journal of hepatology.

Altered modulation of soluble guanylate cyclase in lymphocytes from patients with liver disease

V. Felipo, M. Miñana, M. Serra, 2002, Journal of Molecular Medicine.

Extracellular Vesicles from Hyperammonemic Rats Induce Neuroinflammation and Motor Incoordination in Control Rats

V. Felipo, C. Montoliu, H. González-King, 2020, Cells.

Chronic hyperammonemia alters the circadian rhythms of corticosteroid hormone levels and of motor activity in rats

V. Felipo, M. Errami, M. Llansola, 2009, Journal of neuroscience research.

Minimal hepatic encephalopathy is associated to alterations in eye movements

Marta R. Hidalgo, V. Felipo, C. Montoliu, 2022, Scientific Reports.

Preface

V. Felipo, 2004, Neurochemistry International.

3-Nitro-Tyrosine as a Peripheral Biomarker of Minimal Hepatic Encephalopathy in Patients With Liver Cirrhosis

V. Felipo, C. Montoliu, A. Urios, 2011, The American Journal of Gastroenterology.

Chronic hyperammonemia alters motor and neurochemical responses to activation of group i metabotropic glutamate receptors in the nucleus accumbens in rats in vivo

J. Canales, V. Felipo, M. Errami, 2003, Neurobiology of Disease.

Neuronal and inducible nitric oxide synthase expression in the rat cerebellum following portacaval anastomosis

V. Felipo, G. Bodega, I. Suárez, 2005, Brain Research.

Differential role of interleukin‐1β in neuroinflammation‐induced impairment of spatial and nonspatial memory in hyperammonemic rats

V. Felipo, Tiziano Balzano, N. Elmlili, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Protein kinase C isoforms and cell proliferation in neuroblastoma cells.

V. Felipo, M. Miñana, S. Grisolía, 1996, Brain research. Molecular brain research.

Protein kinase C inhibitors, H7 and calphostin C, inhibit induction of DNA synthesis by cytosolic extracts of exponentially growing neuroblastoma cells in isolated nuclei

V. Felipo, S. Grisolía, H. Cabedo, 1994, Brain Research.

H7, an inhibitor of protein kinase C, inhibits tumour cell division in mice bearing ascitic Ehrlich's carcinoma.

A. Llombart‐Bosch, V. Felipo, M. Miñana, 1994, European journal of cancer.

[Normality tables in the Spanish population for psychometric tests used in the diagnosis of minimal hepatic encephalopathy].

V. Felipo, R. Jover, J. Córdoba, 2006, Medicina clinica.

Control of urea synthesis and ammonia detoxification.

V. Felipo, M. Miñana, S. Grisolía, 1993, Advances in experimental medicine and biology.

Long-term ingestion of ammonium increases acetylglutamate and urea levels without affecting the amount of carbamoyl-phosphate synthase.

V. Felipo, M. Miñana, S. Grisolía, 1988, European journal of biochemistry.

Rats with minimal hepatic encephalopathy due to portacaval shunt show differential increase of translocator protein (18 kDa) binding in different brain areas, which is not affected by chronic MAP-kinase p38 inhibition

T. Guilarte, V. Felipo, A. Agustí, 2013, Metabolic Brain Disease.

Rifaximin Improves Spatial Learning and Memory Impairment in Rats with Liver Damage-Associated Neuroinflammation

V. Felipo, M. Malaguarnera, M. Llansola, 2022, Biomedicines.

Neurons exposed to ammonia reproduce the differential alteration in nitric oxide modulation of guanylate cyclase in the cerebellum and cortex of patients with liver cirrhosis

V. Felipo, S. Erceg, R. Rodrigo, 2005, Neurobiology of Disease.

Activation of the metabotropic glutamate receptor mGluR5 prevents glutamate toxicity in primary cultures of cerebellar neurons.

V. Felipo, S. Grisolía, C. Montoliu, 1997, The Journal of pharmacology and experimental therapeutics.

Carnitine Inhibits Hydrolysis of Inositol Phospholipids Induced by Activation of Metabotropic Receptors

V. Felipo, M. Llansola, 1998, Neurochemical Research.

Sildenafil citrate improves perinatal outcome in fetuses from pre‐eclamptic rats

V. Felipo, V. Serra, A. Pellicer, 2012, BJOG : an international journal of obstetrics and gynaecology.

Research report Alteration of mitochondrial calcium homeostasis by ammonia-induced activation of NMDA receptors in rat brain in vivo

V. Felipo, E. Kosenko, Y. Kaminsky, 2000 .

The precursor of rat liver mitochondrial glutamate dehydrogenase has enzymatic activity.

V. Felipo, S. Grisolía, E. Knecht, 1983, European Journal of Biochemistry.

Is cognitive impairment in cirrhotic patients due to increased peroxynitrite and oxidative stress?

V. Felipo, C. Montoliu, D. Escudero-García, 2015, Antioxidants & redox signaling.

Neuroinflammation and neurological alterations in chronic liver diseases

V. Felipo, C. Montoliu, M. Llansola, 2015 .

5'-adenosine monophosphate inhibits ternary complex formation by rat liver eIF-2.

V. Felipo, S. Grisolía, 1987, Biochemical and biophysical research communications.

The expression levels of prolyl oligopeptidase responds not only to neuroinflammation but also to systemic inflammation upon liver failure in rat models and cirrhotic patients

V. Felipo, J. Tenorio-Laranga, C. Montoliu, 2015, Journal of Neuroinflammation.

Inherited neuromuscular diseases. Translation from pathomechanisms to therapies.

V. Felipo, C. Espinós, F. Palau, 2009, Advances in experimental medicine and biology.

Cerebral oedema is not responsible for motor or cognitive deficits in rats with hepatic encephalopathy

V. Felipo, P. López-Larrubia, S. Cerdán, 2014, Liver international : official journal of the International Association for the Study of the Liver.

638 3-NITRO-TYROSINE AS A PERIPHERAL BIOMARKER OF MINIMAL HEPATIC ENCEPHALOPATHY IN PATIENTS WITH LIVER CIRRHOSIS

V. Felipo, C. Carda, C. Montoliu, 2012 .

Contribution of altered signal transduction associated to glutamate receptors in brain to the neurological alterations of hepatic encephalopathy.

V. Felipo, 2006, World journal of gastroenterology.

Synthesis of new 2-arylamino-6-trifluoromethylpyridine-3-carboxylic acid derivatives and investigation of their analgesic activity.

V. Felipo, M. Morelli, O. Cauli, 2004, Bioorganic & medicinal chemistry.

Haemodynamic effects of long‐term administration of sildenafil in normotensive pregnant and non‐pregnant rats

V. Felipo, V. Serra, A. Pellicer, 2011, BJOG : an international journal of obstetrics and gynaecology.

Plasma Extracellular Vesicles Play a Role in Immune System Modulation in Minimal Hepatic Encephalopathy

V. Felipo, C. Montoliu, T. Rubio, 2022, International journal of molecular sciences.

Control of urea synthesis and ammonia utilization in protein deprivation and refeeding.

V. Felipo, M. Miñana, S. Grisolía, 1991, Archives of biochemistry and biophysics.

Paradoxical protection of both protein-free and high protein diets against acute ammonium intoxication.

V. Felipo, M. Miñana, S. Grisolía, 1988, Biochemical and biophysical research communications.

Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms

V. Felipo, C. Montoliu, M. Llansola, 2015, Journal of Neuroinflammation.

Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia

V. Felipo, M. Llansola, Yaiza M. Arenas, 2022, International journal of molecular sciences.

Developmental Exposure to Pesticides Alters Motor Activity and Coordination in Rats: Sex Differences and Underlying Mechanisms

V. Felipo, M. Llansola, A. Agustí, 2018, Neurotoxicity Research.

Sex-dependent effects of developmental exposure to different pesticides on spatial learning. The role of induced neuroinflammation in the hippocampus.

V. Felipo, M. Malaguarnera, M. Llansola, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Selective regional alterations in the content or distribution of neuronal and glial cytoskeletal proteins in brain of rats chronically exposed to 2,5-hexanedione

V. Felipo, R. Rodrigo, M. Hernández-Viadel, 2002, Toxicology and industrial health.

Blocking NMDA Receptors Delays Death in Rats with Acute Liver Failure by Dual Protective Mechanisms in Kidney and Brain

V. Felipo, C. Carda, C. Montoliu, 2014, NeuroMolecular Medicine.

Activation of soluble guanylate cyclase by nitric oxide in lymphocytes correlates with minimal hepatic encephalopathy in cirrhotic patients

V. Felipo, C. Montoliu, A. Urios, 2007 .

GR3027 antagonizes GABAA receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy

V. Felipo, C. Montoliu, M. Llansola, 2015, American journal of physiology. Gastrointestinal and liver physiology.

Pregnenolone sulfate restores the glutamate-nitric-oxide-cGMP pathway and extracellular GABA in cerebellum and learning and motor coordination in hyperammonemic rats.

V. Felipo, O. Cauli, A. Agustí, 2014, ACS chemical neuroscience.

Hepatic encephalopathy: effects of liver failure on brain function

Vicente Felipo, V. Felipo, 2013, Nature Reviews Neuroscience.

Patients with minimal hepatic encephalopathy show impaired mismatch negativity correlating with reduced performance in attention tests

Carmina Montoliu, Amparo Urios, Remedios Giner-Duran, 2012, Hepatology.

Progressive reduction of sleep time and quality in rats with hepatic encephalopathy caused by portacaval shunts

V. Felipo, J. L. Cantero, M. Errami, 2012, Neuroscience.

Developmental exposure to polychlorinated biphenyls 52, 138 or 180 affects differentially learning or motor coordination in adult rats. mechanisms involved

V. Felipo, O. Cauli, J. Boix, 2010, Neuroscience.

Hyperammonemia increases GABAergic tone in the cerebellum but decreases it in the rat cortex.

V. Felipo, O. Cauli, M. Mansouri, 2009, Gastroenterology.

IL-6 and IL-18 in Blood May Discriminate Cirrhotic Patients With and Without Minimal Hepatic Encephalopathy

V. Felipo, C. Montoliu, A. Urios, 2009, Journal of clinical gastroenterology.

Chronic liver failure in rats impairs glutamatergic synaptic transmission and long‐term potentiation in hippocampus and learning ability

V. Felipo, S. Erceg, M. Llansola, 2007, The European journal of neuroscience.

A simple animal model of hyperammonemia

V. Felipo, M. Miñana, S. Grisolía, 1989, Hepatology.

Acute ammonia intoxication induces an NMDA receptor‐mediated increase in poly(ADP‐ribose) polymerase level and NAD+ metabolism in nuclei of rat brain cells

V. Felipo, E. Kosenko, N. Venediktova, 2004, Journal of neurochemistry.

Golexanolone, a GABAA receptor modulating steroid antagonist, restores motor coordination and cognitive function in hyperammonemic rats by dual effects on peripheral inflammation and neuroinflammation

V. Felipo, T. Blackburn, M. Llansola, 2022, CNS neuroscience & therapeutics.

Extracellular Vesicles From Hyperammonemic Rats Induce Neuroinflammation in Cerebellum of Normal Rats: Role of Increased TNFα Content

V. Felipo, M. Martínez-García, Paula Izquierdo‐Altarejos, 2022, Frontiers in Immunology.

Chronic hyperammonemia alters extracellular glutamate, glutamine and GABA and membrane expression of their transporters in rat cerebellum. Modulation by extracellular cGMP

V. Felipo, C. Montoliu, A. Cabrera-Pastor, 2019, Neuropharmacology.

A Multiomic Study To Unravel The Effects Of Developmental Exposure To Endosulfan In Rats: Molecular Explanation For Sex-Dependent Effects.

A. Conesa, V. Felipo, Sonia Tarazona, 2019, ACS chemical neuroscience.

Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors

V. Felipo, M. Malaguarnera, M. Llansola, 2019, Front. Pharmacol..

Increasing extracellular cGMP in cerebellum in vivo reduces neuroinflammation, GABAergic tone and motor in-coordination in hyperammonemic rats

V. Felipo, M. Malaguarnera, M. Llansola, 2017, Brain, Behavior, and Immunity.

Chronic hyperammonemia alters in opposite ways membrane expression of GluA1 and GluA2 AMPA receptor subunits in cerebellum. Molecular mechanisms involved.

V. Felipo, M. Llansola, A. Cabrera-Pastor, 2018, Biochimica et biophysica acta. Molecular basis of disease.

Inhibition of γ-Secretase Leads to an Increase in Presenilin-1

K. Blennow, V. Felipo, M. Llansola, 2017, Molecular Neurobiology.

Sildenafil reduces neuroinflammation in cerebellum, restores GABAergic tone, and improves motor in‐coordination in rats with hepatic encephalopathy

V. Felipo, C. Montoliu, M. Llansola, 2017, CNS neuroscience & therapeutics.

Extracellular Protein Kinase A Modulates Intracellular Calcium/Calmodulin-Dependent Protein Kinase II, Nitric Oxide Synthase, and the Glutamate-Nitric Oxide-cGMP Pathway in Cerebellum. Differential Effects in Hyperammonemia.

V. Felipo, M. Llansola, A. Cabrera-Pastor, 2016, ACS chemical neuroscience.

Extracellular cGMP Modulates Learning Biphasically by Modulating Glycine Receptors, CaMKII and Glutamate-Nitric Oxide-cGMP Pathway

V. Felipo, M. Malaguarnera, M. Llansola, 2016, Scientific Reports.

Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy

V. Felipo, J. Forteza, M. Llansola, 2016, Journal of Neuroinflammation.

Interplay between glutamatergic and GABAergic neurotransmission alterations in cognitive and motor impairment in minimal hepatic encephalopathy

V. Felipo, C. Montoliu, M. Malaguarnera, 2015, Neurochemistry International.

Translational research in hepatic encephalopathy: New diagnostic possibilities and new therapeutic approaches

V. Felipo, C. Montoliu, M. Malaguarnera, 2014 .

Rats with Mild Bile Duct Ligation Show Hepatic Encephalopathy with Cognitive and Motor Impairment in the Absence of Cirrhosis: Effects of Alcohol Ingestion

V. Felipo, C. Carda, C. Montoliu, 2014, Neurochemical Research.

Hyperammonemia alters the modulation by different neurosteroids of the glutamate–nitric oxide–cyclic GMP pathway through NMDA‐ GABAA‐ or sigma receptors in cerebellum in vivo

V. Felipo, O. Cauli, A. Agustí, 2013, Journal of neurochemistry.

Differential modulation of the glutamate-nitric oxide-cyclic GMP pathway by distinct neurosteroids in cerebellum in vivo

V. Felipo, O. Cauli, A. Agustí, 2011, Neuroscience.

Hyperammonemia induces neuroinflammation that contributes to cognitive impairment in rats with hepatic encephalopathy.

J. García-Verdugo, V. Felipo, O. Cauli, 2010, Gastroenterology.

Mechanisms of cognitive alterations in hyperammonemia and hepatic encephalopathy: Therapeutical implications

V. Felipo, C. Montoliu, M. Llansola, 2009, Neurochemistry International.

Increasing the function of the glutamate‐nitric oxide‐cyclic guanosine monophosphate pathway increases the ability to learn a Y‐maze task

V. Felipo, C. Montoliu, S. Erceg, 2009, Journal of neuroscience research.

Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy

V. Felipo, C. Montoliu, M. Llansola, 2009, Metabolic Brain Disease.

Developmental exposure to polychlorinated biphenyls or methylmercury, but not to its combination, impairs the glutamate–nitric oxide–cyclic GMP pathway and learning in 3-month-old rats

V. Felipo, S. Erceg, O. Cauli, 2008, Neuroscience.

Developmental exposure to polychlorinated biphenyls PCB153 or PCB126 impairs learning ability in young but not in adult rats

V. Felipo, S. Erceg, O. Cauli, 2008, The European journal of neuroscience.

Inflammation and hepatic encephalopathy: Ibuprofen restores learning ability in rats with portacaval shunts

V. Felipo, O. Cauli, J. Boix, 2007, Hepatology.

NMDA Receptor antagonists prevent acute ammonia toxicity in mice

G. Marcaida, V. Felipo, C. Hermenegildo, 1996, Neurochemical Research.

Oral administration of sildenafil restores learning ability in rats with hyperammonemia and with portacaval shunts

V. Felipo, C. Montoliu, S. Erceg, 2005, Hepatology.

Neurobiology of ammonia

R. Butterworth, V. Felipo, 2002, Progress in Neurobiology.

Chronic Moderate Hyperammonemia Impairs Active and Passive Avoidance Behavior and Conditional Discrimination Learning in Rats

V. Felipo, J. Miñarro, M. Aguilar, 2000, Experimental Neurology.

Chronic hyperammonemia impairs the glutamate–nitric oxide–cyclic GMP pathway in cerebellar neurons in culture and in the rat in vivo

V. Felipo, C. Hermenegildo, M. Miñana, 1998, The European journal of neuroscience.

Hyperammonemia Impairs NMDA Receptor-Dependent Long-Term Potentiation in the CA1 of Rat Hippocampus In Vitro

V. Felipo, J. Gaztelu, P. Monfort, 2000, Neurochemical Research.

Aluminium impairs the glutamate-nitric oxide-cGMP pathway in cultured neurons and in rat brain in vivo: molecular mechanisms and implications for neuropathology.

J. Canales, V. Felipo, C. Montoliu, 2001, Journal of inorganic biochemistry.

Prenatal Exposure to Aluminum Reduces Expression of Neuronal Nitric Oxide Synthase and of Soluble Guanylate Cyclase and Impairs Glutamatergic Neurotransmission in Rat Cerebellum

L Manzo, V. Felipo, M. Miñana, 1999, Journal of neurochemistry.

Chronic Exposure to Aluminum Impairs Neuronal Glutamate‐Nitric Oxide‐Cyclic GMP Pathway

V. Felipo, C. Hermenegildo, M. Miñana, 1998, Journal of neurochemistry.

Molecular Mechanisms of the Alterations in NMDA Receptor-Dependent Long-Term Potentiation in Hyperammonemia

V. Felipo, P. Monfort, M. Muñoz, 2005, Metabolic Brain Disease.

Sequential activation of soluble guanylate cyclase, protein kinase G and cGMP-degrading phosphodiesterase is necessary for proper induction of long-term potentiation in CA1 of hippocampus Alterations in hyperammonemia

Omar Cauli, Vicente Felipo, V. Felipo, 2004, Neurochemistry International.

Long-Term Potentiation in Hippocampus Involves Sequential Activation of Soluble Guanylate Cyclase, cGMP-Dependent Protein Kinase, and cGMP-Degrading Phosphodiesterase

V. Felipo, E. Kosenko, P. Monfort, 2002, The Journal of Neuroscience.

Inhibition of protein kinase C induces differentiation in Neuro-2a cells.

V. Felipo, M. Miñana, S. Grisolía, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Alcohol exposure during brain development reduces 3H-MK-801 binding and enhances metabotropic-glutamate receptor-stimulated phosphoinositide hydrolysis in rat hippocampus.

V. Felipo, C. Montoliu, C. Guerri, 1995, Life sciences.

Presence of diadenosine polyphosphates in microdialysis samples from rat cerebellum in vivo: effect of mild hyperammonemia on their receptors

V. Felipo, M. Llansola, J. Pintor, 2013, Purinergic Signalling.

Lymphocyte cytochrome c oxidase, cyclic GMP and cholinergic muscarinic receptors as peripheral indicators of carbon monoxide neurotoxicity after acute and repeated exposure in the rat.

V. Felipo, A. Castoldi, T. Coccini, 2006, Life sciences.

Altered Modulation of Motor Activity by Group I Metabotropic Glutamate Receptors in the Nucleus Accumbens in Hyperammonemic Rats

V. Felipo, M. Errami, M. Llansola, 2005, Metabolic Brain Disease.

Metallothionein‐III Prevents Glutamate and Nitric Oxide Neurotoxicity in Primary Cultures of Cerebellar Neurons

V. Felipo, C. Montoliu, J. Hidalgo, 2000, Journal of neurochemistry.

H7, an inhibitor of protein kinase C, prevents serum-induced phosphorylation of Raf and MAP kinase in neuroblastoma cells

V. Felipo, M. Miñana, S. Grisolía, 1996, Neuroscience Letters.

Differential effects of the protein kinase C inhibitors H7 and calphostin C on the cell cycle of neuroblastoma cells

V. Felipo, S. Grisolía, M. Minana, 1992, Brain Research.

H7, a protein kinase C inhibitor, increases the glutathione content of neuroblastoma cells

V. Felipo, M. Miñana, S. Grisolía, 1992, FEBS letters.

Inhibition of Protein Kinase C Restores Na+, K+‐ATPase Activity in Sciatic Nerve of Diabetic Mice

V. Felipo, C. Hermenegildo, M. Miñana, 1992, Journal of neurochemistry.

Inhibition of protein kinase C arrests proliferation of human tumors

V. Felipo, M. Miñana, S. Grisolía, 1991, FEBS letters.

Actinomycin D decreases protein kinase C content and induces neuritogenesis in neuroblastoma cells

V. Felipo, M. Miñana, S. Grisolía, 1991, FEBS letters.

Effects of hyperammonemia on brain protein kinase C substrates

G. Marcaida, V. Felipo, M. Miñana, 1996, Metabolic Brain Disease.

Hyperammonemia and liver failure alter signal transduction associated with glutamate receptors and modulation of guanylate cyclase by nitric oxide

V. Felipo, C. Montoliu, S. Erceg, 2003 .

Ammonia Prevents Activation of NMDA Receptors by Glutamate in Rat Cerebellar Neuronal Cultures

G. Marcaida, V. Felipo, M. Miñana, 1995, The European journal of neuroscience.

Ebselen prevents chronic alcohol-induced rat hippocampal stress and functional impairment.

V. Felipo, F. J. Romero, F. Bosch-Morell, 2007, Alcoholism, clinical and experimental research.

Advances in Cirrhosis, Hyperammonemia, and Hepatic Encephalopathy

V. Felipo, S. Grisolía, 2012, Advances in Experimental Medicine and Biology.

Animal Models in the Study of Episodic Hepatic Encephalopathy in Cirrhosis

V. Felipo, R. Jover, R. Rodrigo, 2005, Metabolic Brain Disease.

230 Usefulness of the measurement of critical flicker frequency in the diagnosis of minimal hepatic encephalopathy (MHE)

V. Felipo, R. Jover, J. Córdoba, 2006 .

Treatment of hyperammonemia with carbamylglutamate in rats

V. Felipo, M. Miñana, S. Grisolía, 1992, Hepatology.

Effects of Hyperammonemia and Liver Failure on Glutamatergic Neurotransmission

V. Felipo, E. Kosenko, P. Monfort, 2002, Metabolic Brain Disease.

Altered content and modulation of soluble guanylate cyclase in the cerebellum of rats with portacaval anastomosis

V. Felipo, L. Martinez, J. Lopez‐Talavera, 2001, Neuroscience.

Differential effects of acute and chronic hyperammonemia on signal transduction pathways associated to NMDA receptors

V. Felipo, C. Hermenegildo, C. Montoliu, 2000, Neurochemistry International.

Activation of N‐methyl‐D‐aspartate receptors in rat brain in vivo following acute ammonia intoxication: Characterization by in vivo brain microdialysis

V. Felipo, C. Hermenegildo, P. Monfort, 2000, Hepatology.

Glutamate and muscarinic receptors in the molecular mechanisms of acute ammonia toxicity and of its prevention.

V. Felipo, C. Hermenegildo, M. Miñana, 1997, Advances in experimental medicine and biology.

Hepatic Encephalopathy, Hyperammonemia, and Ammonia Toxicity

V. Felipo, S. Grisolía, 2012, Advances in Experimental Medicine and Biology.

Molecular mechanism of acute ammonia toxicity and of its prevention by L-carnitine.

G. Marcaida, V. Felipo, M. Miñana, 1994, Advances in experimental medicine and biology.

Motor activity is modulated via different neuronal circuits in rats with chronic liver failure than in normal rats

V. Felipo, M. Llansola, O. Cauli, 2007, The European journal of neuroscience.

Acute liver failure-induced death of rats is delayed or prevented by blocking NMDA receptors in brain.

V. Felipo, O. Cauli, A. Agustí, 2008, American journal of physiology. Gastrointestinal and liver physiology.

Pharmacological manipulation of cyclic GMP levels in brain restores learning ability in animal models of hepatic encephalopathy: therapeutic implications

V. Felipo, S. Erceg, O. Cauli, 2006, Neuropsychiatric disease and treatment.

Neuroinflammation contributes to hypokinesia in rats with hepatic encephalopathy: Ibuprofen restores its motor activity

V. Felipo, M. Llansola, O. Cauli, 2009, Journal of neuroscience research.

Phosphate-activated glutaminase activity is enhanced in brain, intestine and kidneys of rats following portacaval anastomosis.

V. Felipo, J. Bautista, Laura Collantes de Terán, 2006, World journal of gastroenterology.

Bile duct ligation plus hyperammonemia in rats reproduces the alterations in the modulation of soluble guanylate cyclase by nitric oxide in brain of cirrhotic patients

V. Felipo, R. Jover, J. Sáez-Valero, 2005, Neuroscience.

Original Paper

V. Felipo, C. Fidalgo, J. Arias, 2022 .

Transport and regulation of polypeptide precursors of mature mitochondrial proteins.

V. Felipo, S. Grisolía, 1984, Current topics in cellular regulation.

Focal cortical damage parallels cognitive impairment in minimal hepatic encephalopathy

Miguel A. Serra, Vicente Belloch, Mercedes Atienza, 2012, NeuroImage.

Role of NMDA receptors in acute liver failure and ammonia toxicity: Therapeutical implications

V. Felipo, O. Cauli, A. Agustí, 2009, Neurochemistry International.

Adenosine 5'‐triphosphate stimulates the release of polypeptides from mitochondria

V. Felipo, S. Grisolía, Santiago Grisolía, 1985, FEBS letters.

Rats that consume caffeine show decreased brain protein synthesis

V. Felipo, M. Miñana, S. Grisolía, 2004, Neurochemical Research.

Retention of actin synthesis in liver under conditions that inhibit synthesis of almost all other proteins

V. Felipo, Santiago Grisolía, 1987, FEBS letters.

Precursors of mitochondrial proteins are degraded in the cytosol at different rates

V. Felipo, Santiago Grisolía, 1986, FEBS letters.

Exit of proteins and fragments thereof from mitochondria is accelerated by the import of cytosolic synthesized proteins.

V. Felipo, S. Grisolía, E. Knecht, 1983, Biochemical and biophysical research communications.

Cell-free synthesis and processing of a large precursor of glutamate dehydrogenase of rat liver.

V. Felipo, S. Grisolía, J. Hernández-Yago, 1982, Biochemical and biophysical research communications.

Brain cholinergic impairment in liver failure

V. Felipo, R. Jover, O. Cauli, 2008, Brain : a journal of neurology.

Extracellular vesicles from mesenchymal stem cells reduce neuroinflammation in hippocampus and restore cognitive function in hyperammonemic rats

V. Felipo, V. Moreno-Manzano, Carlos Sánchez-Huertas, 2023, Journal of Neuroinflammation.

Chronic hyperammonemia induces peripheral inflammation that leads to cognitive impairment in rats: reversal by anti-tnfa treatment.

V. Felipo, J. Forteza, S. Gil-Perotín, 2020, Journal of hepatology.

Extracellular cGMP Reverses Altered Membrane Expression of AMPA Receptors in Hippocampus of Hyperammonemic Rats: Underlying Mechanisms

V. Felipo, A. Cabrera-Pastor, Yaiza M Arenas, 2018, Molecular Neurobiology.

Extracellular cGMP Reverses Altered Membrane Expression of AMPA Receptors in Hippocampus of Hyperammonemic Rats: Underlying Mechanisms

V. Felipo, A. Cabrera-Pastor, Yaiza M Arenas, 2018, Molecular Neurobiology.

Hyperammonemia alters membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus by enhancing activation of the IL-1 receptor: underlying mechanisms

V. Felipo, Yaiza M. Arenas, A. Cabrera-Pastor, 2018, Journal of Neuroinflammation.

Extracellular Cyclic GMP Modulates Membrane Expression of The GluA1 and GluA2 Subunits of AMPA Receptor in Cerebellum: Molecular Mechanisms Involved

V. Felipo, Tiziano Balzano, A. Cabrera-Pastor, 2017, Scientific Reports.

Reducing Peripheral Inflammation with Infliximab Reduces Neuroinflammation and Improves Cognition in Rats with Hepatic Encephalopathy

J. García-Verdugo, V. Felipo, J. Forteza, 2016, Front. Mol. Neurosci..

In vivo administration of extracellular cGMP normalizes TNF-α and membrane expression of AMPA receptors in hippocampus and spatial reference memory but not IL-1β, NMDA receptors in membrane and working memory in hyperammonemic rats

V. Felipo, M. Llansola, Tiziano Balzano, 2016, Brain, Behavior, and Immunity.

Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane

V. Felipo, M. Malaguarnera, M. Llansola, 2016, Journal of Neuroinflammation.

Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms

V. Felipo, C. Montoliu, M. Llansola, 2015, Journal of Neuroinflammation.

Contribution of hyperammonemia and inflammatory factors to cognitive impairment in minimal hepatic encephalopathy

V. Felipo, C. Montoliu, A. Urios, 2012, Metabolic Brain Disease.

Neurochemistry of ammonia

R. Butterworth, V. Felipo, 2002, Neurochemistry International.

Molecular mechanism of acute ammonia toxicity: role of NMDA receptors

J. Canales, V. Felipo, E. Kosenko, 2002, Neurochemistry International.

Activation of NMDA receptors induces protein kinase A‐mediated phosphorylation and degradation of matrin 3. Blocking these effects prevents NMDA‐induced neuronal death

V. Felipo, J. Calvete, R. Berezney, 2005, Journal of neurochemistry.

Hyperammonemia alters glycinergic neurotransmission and modulation of the glutamate‐nitric oxide‐cGMP pathway by extracellular glycine in cerebellum in vivo

V. Felipo, A. Cabrera-Pastor, Lucas Taoro‐González, 2016, Journal of neurochemistry.

Endosulfan and Cypermethrin Pesticide Mixture Induces Synergistic or Antagonistic Effects on Developmental Exposed Rats Depending on the Analyzed Behavioral or Neurochemical End Points.

V. Felipo, M. Llansola, A. Agustí, 2017, ACS chemical neuroscience.

Motor and Cognitive Performance in Patients with Liver Cirrhosis with Minimal Hepatic Encephalopathy

R. Tabarés-Seisdedos, V. Felipo, E. Kosenko, 2020, Journal of clinical medicine.

Histological Features of Cerebellar Neuropathology in Patients With Alcoholic and Nonalcoholic Steatohepatitis

V. Felipo, J. Forteza, C. Montoliu, 2018, Journal of neuropathology and experimental neurology.

The Cerebellum of Patients with Steatohepatitis Shows Lymphocyte Infiltration, Microglial Activation and Loss of Purkinje and Granular Neurons

V. Felipo, J. Forteza, C. Montoliu, 2018, Scientific Reports.

Urea cycle dysregulation in non-alcoholic fatty liver disease.

S. Hamilton-Dutoit, V. Felipo, R. Jalan, 2018, Journal of hepatology.

NMDA‐induced phosphorylation of the microtubule‐associated protein MAP‐2 is mediated by activation of nitric oxide synthase and MAP kinase

V. Felipo, M. Llansola, R. Sáez, 2001, The European journal of neuroscience.

Superoxide production and antioxidant enzymes in ammonia intoxication in rats.

V. Felipo, C. Hermenegildo, E. Kosenko, 1997, Free radical research.

Sources of oxygen radicals in brain in acute ammonia intoxication in vivo

V. Felipo, E. Kosenko, N. Venediktova, 2003, Brain Research.

Blocking NMDA receptors prevents the oxidative stress induced by acute ammonia intoxication.

V. Felipo, E. Kosenko, Y. Kaminski, 1999, Free radical biology & medicine.

Value of the critical flicker frequency in patients with minimal hepatic encephalopathy

Manuel Romero-Gómez, Carmina Montoliu, Vicente Felipo, 2007, Hepatology.

Modulation of NMDA receptors in the cerebellum. 1. Properties of the NMDA receptor that modulate its function

V. Felipo, M. Llansola, O. Cauli, 2008, The Cerebellum.

Glutamine synthetase activity and glutamine content in brain: modulation by NMDA receptors and nitric oxide

V. Felipo, E. Kosenko, C. Montoliu, 2003, Neurochemistry International.

Metabolic syndrome is associated with poor response to rifaximin in minimal hepatic encephalopathy

V. Felipo, E. Kosenko, C. Montoliu, 2022, Scientific Reports.

Metabolic syndrome is associated with poor response to rifaximin in minimal hepatic encephalopathy

V. Felipo, E. Kosenko, C. Montoliu, 2022, Scientific Reports.

Role of cyclic GMP in glutamate neurotoxicity in primary cultures of cerebellar neurons

V. Felipo, E. Kosenko, C. Montoliu, 1999, Neuropharmacology.

Magnetic resonance analysis of the effects of acute ammonia intoxication on rat brain. Role of NMDA receptors

V. Felipo, P. López-Larrubia, S. Cerdán, 2007, Journal of neurochemistry.

Brain edema and inflammatory activation in bile duct ligated rats with diet‐induced hyperammonemia: A model of hepatic encephalopathy in cirrhosis

Omar Cauli, Ricardo Insausti, Miguel Pérez-Mateo, 2006, Hepatology.

NMDA receptors in hyperammonemia and hepatic encephalopathy

V. Felipo, E. Kosenko, C. Montoliu, 2007, Metabolic Brain Disease.

Region selective alterations of soluble guanylate cyclase content and modulation in brain of cirrhotic patients

N. Chatauret, R. Butterworth, V. Felipo, 2002, Hepatology.

Mitochondrial dysfunction in acute hyperammonemia

R. Butterworth, V. Felipo, 2002, Neurochemistry International.

Rats with minimal hepatic encephalopathy show reduced cGMP-dependent protein kinase activity in hypothalamus correlating with circadian rhythms alterations

V. Felipo, J. Gaztelu, M. Llansola, 2015, Chronobiology international.

Cyclic GMP pathways in hepatic encephalopathy. Neurological and therapeutic implications

V. Felipo, C. Montoliu, M. Llansola, 2010, Metabolic Brain Disease.

Alterations in soluble guanylate cyclase content and modulation by nitric oxide in liver disease

N. Chatauret, R. Butterworth, V. Felipo, 2004, Neurochemistry International.

Ammonia prevents glutamate-induced but not low K+-induced apoptosis in cerebellar neurons in culture

V. Felipo, L. Boscá, S. Hortelano, 2003, Neuroscience.

Metabotropic glutamate receptor 5, but not 1, modulates NMDA receptor-mediated activation of neuronal nitric oxide synthase

V. Felipo, M. Llansola, 2010, Neurochemistry International.

Encapsulation of glutamine synthetase in mouse erythrocytes: a new procedure for ammonia detoxification.

V. Felipo, E. Kosenko, N. Venediktova, 2008, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Chronic exposure to aluminium impairs the glutamate-nitric oxide-cyclic GMP pathway in the rat in vivo

V. Felipo, C. Hermenegildo, C. Minoia, 1999, Neurochemistry International.

Modulation of NMDA receptors in the cerebellum. II. Signaling pathways and physiological modulators regulating NMDA receptor function

V. Felipo, M. Llansola, O. Cauli, 2008, The Cerebellum.

Modulation of NMDA receptor function by cyclic AMP in cerebellar neurones in culture

V. Felipo, C. Montoliu, M. Llansola, 2004, Journal of neurochemistry.

L-Carnitine increases the affinity of glutamate for quisqualate receptors and prevents glutamate neurotoxicity

V. Felipo, M. Miñana, S. Grisolía, 1994, Neurochemical Research.

Inhibitors of phospholipase C prevent glutamate neurotoxicity in primary cultures of cerebellar neurons.

V. Felipo, M. Llansola, P. Monfort, 2000, The Journal of pharmacology and experimental therapeutics.

Glutamatergic Neurotransmission, Aluminium and Alzheimer’s Disease

V. Felipo, 2001 .

Gender differences in spatial learning, synaptic activity, and long-term potentiation in the hippocampus in rats: molecular mechanisms.

V. Felipo, M. Llansola, P. Monfort, 2015, ACS chemical neuroscience.

Chronic exposure to ammonia induces isoform‐selective alterations in the intracellular distribution and NMDA receptor‐mediated translocation of protein kinase C in cerebellar neurons in culture

V. Felipo, C. Montoliu, L. Costa, 2005, Journal of neurochemistry.

Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the adult rat

V. Felipo, C. Guerri, J. Boix, 2009, Journal of neurochemistry.

Bacteroides uniformis CECT 7771 Modulates the Brain Reward Response to Reduce Binge Eating and Anxiety-Like Behavior in Rat

V. Felipo, J. Forteza, N. Avena, 2021, Molecular Neurobiology.

Cirrhosis, Hepatic Encephalopathy, and Ammonium Toxicity

V. Felipo, M. Miñana, S. Grisolía, 1990, Advances in Experimental Medicine and Biology.

Mass Spectrometrical Analysis of Galectin Proteins in Primary Rat Cerebellar Astrocytes

V. Felipo, E. Engidawork, S. U. Kang, 2006, Neurochemical Research.

Restoration of learning ability in hyperammonemic rats by increasing extracellular cGMP in brain

V. Felipo, C. Montoliu, S. Erceg, 2005, Brain Research.

The expression of nNOS, iNOS and nitrotyrosine is increased in the rat cerebral cortex in experimental hepatic encephalopathy

V. Felipo, G. Bodega, I. Suárez, 2006, Neuropathology and applied neurobiology.

A New Score Unveils a High Prevalence of Mild Cognitive Impairment in Patients with Nonalcoholic Fatty Liver Disease

V. Felipo, C. Montoliu, D. Escudero-García, 2021, Journal of clinical medicine.

Cerebellum proteomics addressing the cognitive deficit of rats perinatally exposed to the food-relevant polychlorinated biphenyl 138.

Patrick De Boever, Vicente Felipo, Laura Brunelli, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Polychlorinated Biphenyls PCB 153 and PCB 126 Impair the Glutamate–Nitric Oxide–cGMP Pathway in Cerebellar Neurons in Culture by Different Mechanisms

V. Felipo, C. Montoliu, M. Llansola, 2009, Neurotoxicity Research.

Insight into the neuroproteomics effects of the food-contaminant non-dioxin like polychlorinated biphenyls.

Vicente Felipo, Alessandro Mariani, Laura Brunelli, 2012, Journal of proteomics.

Patients with Minimal Hepatic Encephalopathy Show Altered Thermal Sensitivity and Autonomic Function

V. Felipo, E. Kosenko, C. Montoliu, 2021, Journal of clinical medicine.

Nitroarginine, an Inhibitor of Nitric Oxide Synthase, Prevents Changes in Superoxide Radical and Antioxidant Enzymes Induced by Ammonia Intoxication

V. Felipo, C. Hermenegildo, E. Kosenko, 1998, Metabolic Brain Disease.

Activation of soluble guanylate cyclase by nitric oxide is increased in lymphocytes from both rats chronically exposed to 2,5-hexanedione and workers chronically exposed to n-hexane.

V. Felipo, M. Prieto-Castelló, A. Cardona, 2007, Toxicology.

Early spatial memory deficit induced by 2,5-hexanedione in the rat.

W. K. Cullen, R. Anwyl, V. Felipo, 2002, Toxicology letters.

Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms

V. Felipo, C. Montoliu, M. Llansola, 2015, Journal of Neuroinflammation.

Serum metabolic signature of minimal hepatic encephalopathy by (1)H-nuclear magnetic resonance.

V. Felipo, A. Pineda-Lucena, C. Montoliu, 2010, Journal of proteome research.

A multi-omic study for uncovering molecular mechanisms associated with hyperammonemia-induced cerebellar function impairment in rats

A. Conesa, V. Felipo, Sonia Tarazona, 2021, Cell Biology and Toxicology.

CHRONIC LIVER FAILURE: POTENTIAL ROLE OF NITRIC OXIDE

V. Felipo, C. Rose, 2013 .

Impaired release of corticosterone from adrenals contributes to impairment of circadian rhythms of activity in hyperammonemic rats.

V. Felipo, M. Errami, M. Llansola, 2013, Archives of biochemistry and biophysics.

Differential effects of chronic hyperammonemia on modulation of the glutamate–nitric oxide–cGMP pathway by metabotropic glutamate receptor 5 and low and high affinity AMPA receptors in cerebellum in vivo

V. Felipo, M. Llansola, J. Boix, 2012, Neurochemistry International.

Chronic exposure to ammonia alters the modulation of phosphorylation of microtubule-associated protein 2 by metabotropic glutamate receptors 1 and 5 in cerebellar neurons in culture

V. Felipo, S. Erceg, M. Llansola, 2005, Neuroscience.

A novel N-methyl-D-aspartate receptor open channel blocker with in vivo neuroprotectant activity.

V. Felipo, E. Pérez-Payá, C. Montoliu, 2002, The Journal of pharmacology and experimental therapeutics.

GAIT-GM: Galaxy tools for modeling metabolite changes as a function of gene expression

A. Conesa, V. Felipo, L. McIntyre, 2020, bioRxiv.

Chronic hyperammonemia induces tonic activation of NMDA receptors in cerebellum

V. Felipo, M. Errami, J. Boix, 2010, Journal of neurochemistry.

Treatment with sildenafil prevents impairment of learning in rats born to pre-eclamptic mothers

V. Felipo, A. Pellicer, O. Cauli, 2010, Neuroscience.

Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane

V. Felipo, M. Malaguarnera, M. Llansola, 2016, Journal of Neuroinflammation.

In vivo exposure to carbon monoxide causes delayed impairment of activation of soluble guanylate cyclase by nitric oxide in rat brain cortex and cerebellum

V. Felipo, S. Erceg, A. Castoldi, 2004, Journal of neurochemistry.

Polychlorinated biphenyls PCB 52, PCB 180, and PCB 138 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture by different mechanisms.

V. Felipo, C. Montoliu, M. Llansola, 2010, Chemical research in toxicology.

Inhibition of protein kinase C induces differentiation of neuroblastoma cells

V. Felipo, M. Miñana, S. Grisolía, 1989, FEBS letters.

A specific inhibitor of protein kinase C induces differentiation of neuroblastoma cells.

V. Felipo, M. Miñana, S. Grisolía, 1990, The Journal of biological chemistry.

Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-κB pathway

V. Felipo, J. Forteza, C. Montoliu, 2020, Journal of Neuroinflammation.

Hyperammonemia Alters the Function of AMPA and NMDA Receptors in Hippocampus: Extracellular cGMP Reverses Some of These Alterations

V. Felipo, V. Teruel-Martí, A. Cabrera-Pastor, 2022, Neurochemical Research.

Chronic exposure to ammonia alters basal and NMDA-induced phosphorylation of NMDA receptor-subunit NR1

V. Felipo, A. Sánchez-Pérez, 2006, Neuroscience.

Prevention of in vivo excitotoxicity by a family of trialkylglycines, a novel class of neuroprotectants.

J. Canales, V. Felipo, F. Sánchez-Baeza, 2002, The Journal of pharmacology and experimental therapeutics.

cGMP modulates stem cells differentiation to neurons in brain in vivo

J. García-Verdugo, V. Felipo, A. Pellicer, 2010, Neuroscience.

Effects of acute hyperammonemiain Vivo on oxidative metabolism in nonsynaptic rat brain mitochondria

V. Felipo, S. Grisolía, E. Kosenko, 1997, Metabolic Brain Disease.

Chronic hyperammonemia alters protein phosphorylation and glutamate receptor-associated signal transduction in brain

V. Felipo, C. Montoliu, M. Llansola, 2002, Neurochemistry International.

Modulation of Glutamine Synthesis in Cultured Astrocytes by Nitric Oxide

G. Marcaida, V. Felipo, C. Hermenegildo, 1997, Cellular and Molecular Neurobiology.

Hyperammonemia induces polymerization of brain tubulin

V. Felipo, M. Miñana, S. Grisolía, 1990, Neurochemical Research.

Selective regional distribution of tubulin induced in cerebrum by hyperammonemia

V. Felipo, M. Miñana, S. Grisolía, 1989, Neurochemical Research.

Chronic Exposure to Ammonia Alters Pathways Modulating Phosphorylation of Microtubule‐Associated Protein 2 in Cerebellar Neurons in Culture

V. Felipo, M. Llansola, R. Sáez, 1999, Journal of neurochemistry.

Lack of correlation between glutamate-induced depletion of ATP and neuronal death in primary cultures of cerebellum

G. Marcaida, V. Felipo, S. Grisolía, 1995, Brain Research.

Hyperammonemia decreases protein-kinase-C-dependent phosphorylation of microtubule-associated protein 2 and increases its binding to tubulin.

V. Felipo, M. Miñana, S. Grisolía, 1993, European journal of biochemistry.

High Ammonia Levels in Brain Induce Tubulin in Cerebrum but Not in Cerebellum

V. Felipo, M. Miñana, S. Grisolía, 1988, Journal of neurochemistry.

Induction of Rat Brain Tubulin Following Ammonium Ingestion

V. Felipo, M. Miñana, S. Grisolía, 1988, Journal of neurochemistry.

The susceptibility of MAP-2 to proteolytic degradation increases when bound to tubulin

V. Felipo, M. Miñana, S. Grisolía, 1992, Neurochemical Research.

Downregulation of nNOS and synthesis of PGs associated with endotoxin-induced delay in gastric emptying.

J. Esplugues, V. Felipo, E. Quintana, 2002, American journal of physiology. Gastrointestinal and liver physiology.

A Nextflow pipeline for T-cell receptor repertoire reconstruction and analysis from RNA sequencing data

V. Greiff, A. Conesa, V. Felipo, 2022, ImmunoInformatics.

An Inhibitor of Neuronal Exocytosis (DD04107) Displays Long-Lasting In Vivo Activity against Chronic Inflammatory and Neuropathic Pain

V. Felipo, A. Ferrer-Montiel, O. Cauli, 2012, Journal of Pharmacology and Experimental Therapeutics.

Hyperammonemia Enhances GABAergic Neurotransmission in Hippocampus: Underlying Mechanisms and Modulation by Extracellular cGMP

V. Felipo, R. García-García, M. Llansola, 2022, Molecular Neurobiology.

Sustained Recovery of Na+-K+-ATPase Activity in Sciatic Nerve of Diabetic Mice by Administration of H7 or Calphostin C, Inhibitors of PKC

V. Felipo, C. Hermenegildo, M. Miñana, 1993, Diabetes.

A protein-free diet changes synaptosomal membrane fluidity and tyrosine and glutamate transport

V. Felipo, M. Miñana, S. Grisolía, 1989, Neurochemical Research.

Presence of diadenosine polyphosphates in microdialysis samples from rat cerebellum in vivo: effect of mild hyperammonemia on their receptors

V. Felipo, M. Llansola, J. Pintor, 2013, Purinergic Signalling.

Hippocampal long-term potentiation is reduced in mature compared to young male rats but not in female rats

V. Felipo, P. Monfort, 2007, Neuroscience.

Selective improvement by rifaximin of changes in the immunophenotype in patients who improve minimal hepatic encephalopathy

V. Felipo, C. Montoliu, F. Revert, 2019, Journal of Translational Medicine.

Extracellular vesicles from hyperammonemic rats induce neuroinflammation in hippocampus and impair cognition in control rats

V. Felipo, M. Martínez-García, Paula Izquierdo-Altarejos, 2023, Cellular and Molecular Life Sciences.

Mild Cognitive Impairment Is Associated with Enhanced Activation of Th17 Lymphocytes in Non-Alcoholic Fatty Liver Disease

V. Felipo, E. Kosenko, C. Montoliu, 2023, International journal of molecular sciences.

Minimal hepatic encephalopathy is associated with expansion and activation of CD4+CD28−, Th22 and Tfh and B lymphocytes

V. Felipo, C. Montoliu, D. Escudero-García, 2017, Scientific Reports.

Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy

V. Felipo, J. Forteza, M. Llansola, 2016, Journal of Neuroinflammation.

A rare and revealing glimpse of the cerebrospinal fluid of patients with hepatic encephalopathy.

V. Felipo, S. Montagnese, 2016, Journal of hepatology.

Sustained Hyperammonemia Activates NF-κB in Purkinje Neurons Through Activation of the TrkB-PI3K-AKT Pathway by Microglia-Derived BDNF in a Rat Model of Minimal Hepatic Encephalopathy

V. Felipo, Yaiza M Arenas, 2023, Molecular Neurobiology.

Serines 890 and 896 of the NMDA receptor subunit NR1 are differentially phosphorylated by protein kinase C isoforms

V. Felipo, A. Sánchez-Pérez, 2005, Neurochemistry International.

Prenatal exposure to polybrominated diphenylether 99 enhances the function of the glutamate–nitric oxide–cGMP pathway in brain in vivo and in cultured neurons

V. Felipo, C. Montoliu, S. Erceg, 2007, The European journal of neuroscience.

Chronic hyperammonemia, glutamatergic neurotransmission and neurological alterations

V. Felipo, C. Montoliu, M. Llansola, 2013, Metabolic Brain Disease.

T. Guilarte, V. Felipo, A. Agustí, 2014, Metabolic Brain Disease.

Prevention of Ammonia and Glutamate Neurotoxicity by Carnitine: Molecular Mechanisms

V. Felipo, S. Erceg, M. Llansola, 2002, Metabolic Brain Disease.

Brain regional alterations in the modulation of the glutamate–nitric oxide-cGMP pathway in liver cirrhosis Role of hyperammonemia and cell types involved

V. Felipo, R. Rodrigo, 2006, Neurochemistry International.

Reduced white matter microstructural integrity correlates with cognitive deficits in minimal hepatic encephalopathy

C. Forn, C. Ávila, J. García-Panach, 2013, Gut.

589 PATIENTS WITH MINIMAL HEPATIC ENCEPHALOPATHY SHOW IMPAIRED MISMATCH NEGATIVITY CORRELATING WITH REDUCED PERFORMANCE IN ATTENTION TESTS

V. Felipo, C. Montoliu, A. Urios, 2013 .

Modulation of NMDA receptors by AKT kinase

V. Felipo, M. Llansola, A. Sánchez-Pérez, 2006, Neurochemistry International.

Role of nitric oxide and cyclic GMP in glutamate-induced neuronal death

V. Felipo, C. Montoliu, M. Llansola, 2001, Neurotoxicity Research.

Exploratory investigation on nitro- and phospho-proteome cerebellum changes in hyperammonemia and hepatic encephalopathy rat models

V. Felipo, R. Pastorelli, M. Llansola, 2012, Metabolic Brain Disease.

Ammonium Injection Induces an N‐Methyl‐d‐Aspartate Receptor‐Mediated Proteolysis of the Microtubule‐Associated Protein MAP‐2

V. Felipo, M. Miñana, S. Grisolía, 1993, Journal of neurochemistry.

Glutamate‐induced activation of nitric oxide synthase is impaired in cerebral cortex in vivo in rats with chronic liver failure

V. Felipo, S. Erceg, J. Rodríguez-Díaz, 2007, Journal of neurochemistry.

Developmental exposure to PCB153 and methylmercury on sex hormone levels at early and late postnatal periods in rats

V. Felipo, A. Castoldi, T. Coccini, 2006 .

Sildenafil Treatment Eliminates Pruritogenesis and Thermal Hyperalgesia in Rats with Portacaval Shunts

V. Felipo, M. Llansola, A. Agustí, 2017, Neurochemical Research.

V. Felipo, M. Llansola, Tiziano Balzano, 2016, Journal of Neuroinflammation.

Rats with Mild Bile Duct Ligation Show Hepatic Encephalopathy with Cognitive and Motor Impairment in the Absence of Cirrhosis: Effects of Alcohol Ingestion

V. Felipo, C. Carda, C. Montoliu, 2015, Neurochemical Research.

Metabotropic glutamate receptor 5 modulates the nitric oxide-cGMP pathway in cerebellum in vivo through activation of AMPA receptors

V. Felipo, M. Llansola, J. Boix, 2011, Neurochemistry International.

Transport of AMPA receptors during long-term potentiation is impaired in rats with hepatic encephalopathy

V. Felipo, B. Piedrafita, P. Monfort, 2009, Neurochemistry International.

Control of brain glutamine synthesis by NMDA receptors.

V. Felipo, R. Rodrigo, 2007, Frontiers in bioscience : a journal and virtual library.

Correlation of nitric oxide and atrial natriuretic peptide changes with altered cGMP homeostasis in liver cirrhosis

Carmina Montoliu, Vicente Felipo, V. Felipo, 2005, Liver international : official journal of the International Association for the Study of the Liver.

Perinatal exposure to purity-controlled polychlorinated biphenyl 52, 138, or 180 alters toxicogenomic profiles in peripheral blood of rats after 4 months.

V. Felipo, P. De Boever, G. Schoeters, 2013, Chemical research in toxicology.

The influence of HE history, HE status and neuropsychological test type on learning ability in patients with cirrhosis

V. Felipo, C. Montoliu, P. Angeli, 2019, Liver international : official journal of the International Association for the Study of the Liver.

A multi-omic study for uncovering molecular mechanisms associated with hyperammonemia-induced cerebellar function impairment in rats

A. Conesa, V. Felipo, Sonia Tarazona, 2021, Cell Biology and Toxicology.

Alteration of mitochondrial calcium homeostasis by ammonia-induced activation of NMDA receptors in rat brain in vivo

V. Felipo, E. Kosenko, Y. Kaminsky, 2000, Brain Research.

Effects of acute hyperammonemia in vivo on oxidative metabolism in nonsynaptic rat brain mitochondria.

V. Felipo, S. Grisolía, E. Kosenko, 1997, Metabolic brain disease.

Chronic hyperammonemia prevents changes in brain energy and ammonia metabolites induced by acute ammonium intoxication.

V. Felipo, M. Miñana, S. Grisolía, 1993, Biochimica et biophysica acta.

Nitroarginine, an inhibitor of nitric oxide synthetase, attenuates ammonia toxicity and ammonia-induced alterations in brain metabolism

V. Felipo, M. Miñana, S. Grisolía, 1995, Neurochemical Research.

Chronic hyperammonemia in vivo impairs long‐term potentiation in hippocampus by altering activation of cyclic GMP‐dependent‐protein kinase and of phosphodiesterase 5

V. Felipo, P. Monfort, M. Muñoz, 2005, Journal of neurochemistry.

Roles of the NMDA Receptor and EAAC1 Transporter in the Modulation of Extracellular Glutamate by Low and High Affinity AMPA Receptors in the Cerebellum in Vivo: Differential Alteration in Chronic Hyperammonemia.

V. Felipo, M. Llansola, A. Cabrera-Pastor, 2015, ACS chemical neuroscience.

Determination of intracellular ATP in primary cultures of neurons.

G. Marcaida, V. Felipo, M. Miñana, 1997, Brain research. Brain research protocols.

Hyperammonemia impairs long-term potentiation in hippocampus by altering the modulation of cGMP-degrading phosphodiesterase by protein kinase G

V. Felipo, P. Monfort, M. Muñoz, 2004, Neurobiology of Disease.

Role of NMDA and AMPA glutamatergic receptors in the effects of social defeat on the rewarding properties of MDMA in mice

V. Felipo, M. Llansola, J. Miñarro, 2018, The European journal of neuroscience.

Current state of knowledge of hepatic encephalopathy (part II): changes in brain white matter tracts integrity are associated with cognitive deficits in minimal hepatic encephalopathy

V. Felipo, C. Montoliu, 2016, Metabolic brain disease.

Carnitine prevents NMDA receptor-mediated activation of MAP-kinase and phosphorylation of microtubule-associated protein 2 in cerebellar neurons in culture

V. Felipo, M. Llansola, 2002, Brain Research.

Hyperammonemia decreases body fat content in rat

V. Felipo, M. Miñana, S. Grisolía, 1989, FEBS Letters.

Activation of NMDA receptor mediates the toxicity of ammonia and the effects of ammonia on the microtubule-associated protein MAP-2.

V. Felipo, M. Miñana, S. Grisolía, 1993, Advances in experimental medicine and biology.

Chronic hyperammonemia in rats impairs activation of soluble guanylate cyclase in neurons and in lymphocytes: a putative peripheral marker for neurological alterations.

V. Felipo, M. Miñana, C. Montoliu, 1999, Biochemical and biophysical research communications.

A single transient episode of hyperammonemia induces long-lasting alterations in protein kinase A.

V. Felipo, C. Montoliu, M. Serra, 2007, American journal of physiology. Gastrointestinal and liver physiology.

Carbachol-Induced Hydrolysis of Phospholipids in Hippocampal Slices May Be Mediated in Part By Subsequent Activation of Metabotropic Glutamate Receptors

V. Felipo, C. Hermenegildo, M. Miñana, 1998, Neurochemical Research.

Altered Modulation of Soluble Guanylate Cyclase by Nitric Oxide in Patients with Liver Disease

V. Felipo, M. Miñana, C. Montoliu, 2002, Metabolic Brain Disease.

Diet induced hyperammonemia decreases neuronal nuclear size in rat entorhinal cortex

R. Insausti, V. Felipo, A. Insausti, 1997, Neuroscience Letters.

High ammonia levels decrease brain acetylcholinesterase activity both in vivo and in vitro.

V. Felipo, M. Miñana, S. Grisolía, 1994, Molecular and Chemical Neuropathology.

Prevention of glutamate neurotoxicity in cultured neurons by 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran (CR-6), a scavenger of nitric oxide.

V. Felipo, C. Montoliu, A. Messeguer, 1999, Biochemical pharmacology.

The effects of hyperammonemia in learning and brain metabolic activity

V. Felipo, C. Fidalgo, J. Arias, 2014, Metabolic Brain Disease.

Hyperammonemia inhibits the natriuretic peptide receptor 2 (NPR-2)-mediated cyclic GMP synthesis in the astrocytic compartment of rat cerebral cortex slices.

V. Felipo, M. Zielińska, J. Albrecht, 2007, Neurotoxicology.

Hyperammonemia alters membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus by enhancing activation of the IL-1 receptor: underlying mechanisms

V. Felipo, A. Cabrera-Pastor, Yaiza M Arenas, 2018, Journal of Neuroinflammation.

Hyperammonaemia alters the mechanisms by which metabotropic glutamate receptors in nucleus accumbens modulate motor function

V. Felipo, O. Cauli, R. Rodrigo, 2007, Journal of neurochemistry.

Inhibition of proliferation of primary cell cultures and of L-132 cells by protein kinase inhibitors

V. Felipo, S. Grisolía, H. Cabedo, 1993 .

Chronic exposure to 2,5-hexanedione impairs the glutamate-nitric oxide-cyclic GMP pathway in cerebellar neurons in culture and in rat brain in vivo

J. Canales, V. Felipo, C. Montoliu, 2003, Neurochemistry International.

Long‐term ingestion of ammonium inhibits lysosomal proteolysis in rat liver

V. Felipo, M. Miñana, S. Grisolía, 1988, FEBS letters.

Preparation and handling of brain mitochondria useful to study uptake and release of calcium.

V. Felipo, E. Kosenko, Y. Kaminsky, 2001, Brain research. Brain research protocols.

Tadalafil Treatment Improves Inflammation, Cognitive Function, And Mismatch Negativity Of Patients With Low Urinary Tract Symptoms And Erectile Dysfunction

V. Felipo, C. Montoliu, A. Urios, 2019, Scientific Reports.

Differential long-term effects of developmental exposure to polychlorinated biphenyls 52, 138 or 180 on motor activity and neurotransmission. Gender dependence and mechanisms involved

V. Felipo, O. Cauli, H. Leslie, 2011, Neurochemistry International.

Developmental exposure to polychlorinated biphenyls PCB153 or PCB126 impairs learning ability in young but not in adult rats

V. Felipo, S. Erceg, O. Cauli, 2007 .

Pathological and therapeutic effects of extracellular vesicles in neurological and neurodegenerative diseases

V. Felipo, V. Moreno-Manzano, Paula Izquierdo-Altarejos, 2023, Neural regeneration research.

Extracellular Cyclic GMP Modulates Membrane Expression of The GluA1 and GluA2 Subunits of AMPA Receptor in Cerebellum: Molecular Mechanisms Involved

V. Felipo, Tiziano Balzano, A. Cabrera-Pastor, 2017, Scientific Reports.

Acute liver failure-induced death of rats is delayed or prevented by blocking NMDA receptors in brain.

V. Felipo, O. Cauli, A. Agustí, 2008, American journal of physiology. Gastrointestinal and liver physiology.

Selective improvement by rifaximin of changes in the immunophenotype in patients who improve minimal hepatic encephalopathy

V. Felipo, C. Montoliu, F. Revert, 2019, Journal of Translational Medicine.

V. Felipo, M. Llansola, Tiziano Balzano, 2016, Brain, Behavior, and Immunity.

Experimental models of hepatic encephalopathy: ISHEN guidelines

M. Norenberg, R. Butterworth, V. Felipo, 2009, Liver international : official journal of the International Association for the Study of the Liver.

Increasing extracellular cGMP in cerebellum in vivo reduces neuroinflammation, GABAergic tone and motor in-coordination in hyperammonemic rats

V. Felipo, M. Malaguarnera, M. Llansola, 2017, Brain, Behavior, and Immunity.

Focal cortical damage parallels cognitive impairment in minimal hepatic encephalopathy

V. Felipo, M. Atienza, C. Montoliu, 2012, NeuroImage.

Extracellular vesicles from mesenchymal stem cells reduce neuroinflammation in hippocampus and restore cognitive function in hyperammonemic rats

V. Felipo, V. Moreno-Manzano, Carlos Sánchez-Huertas, 2023, Journal of Neuroinflammation.

Hyperammonemia increases GABAergic tone in the cerebellum but decreases it in the rat cortex.

V. Felipo, O. Cauli, M. Mansouri, 2009, Gastroenterology.

Hepatic encephalopathy

S. Taylor-Robinson, R. Dhiman, V. Felipo, 2022, Nature Reviews Disease Primers.

Chronic hyperammonemia, glutamatergic neurotransmission and neurological alterations

V. Felipo, C. Montoliu, M. Llansola, 2012, Metabolic Brain Disease.

p38 MAP kinase is a therapeutic target for hepatic encephalopathy in rats with portacaval shunts

V. Felipo, M. Llansola, O. Cauli, 2011, Gut.

Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests.

V. Felipo, C. Montoliu, V. Belloch, 2014, World journal of gastroenterology.

Patients who died with steatohepatitis or liver cirrhosis show neuroinflammation and neuronal loss in hippocampus

V. Felipo, C. Montoliu, M. Llansola, 2023, European journal of neurology.

Haemodynamic effects of long‐term administration of sildenafil in normotensive pregnant and non‐pregnant rats

V. Felipo, V. Serra, A. Pellicer, 2011, BJOG : an international journal of obstetrics and gynaecology.