J. Lifson

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Transient antiretroviral treatment during acute simian immunodeficiency virus infection facilitates long-term control of the virus.

M. Nowak, D. Wodarz, R. Arnaout, 2000, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Association of strong virus-specific CD4 T cell responses with efficient natural control of primary HIV-1 infection

D. Cornforth, I. Williams, J. Lifson, 2004, AIDS.

Retroviral Recombination In Vivo: Viral Replication Patterns and Genetic Structure of Simian Immunodeficiency Virus (SIV) Populations in Rhesus Macaques after Simultaneous or Sequential Intravaginal Inoculation with SIVmac239Δvpx/Δvpr and SIVmac239Δnef

Christopher J. Miller, R. Desrosiers, Eun-Young Kim, 2005, Journal of Virology.

Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines

D. Montefiori, L. Picker, J. Lifson, 2012, Nature Medicine.

Distribution and three-dimensional structure of AIDS virus envelope spikes

J. Lifson, J. Bess, G. Ofek, 2006, Nature.

Human immunodeficiency virus integration in a cell-free system

P. Brown, J. Lifson, V. Ellison, 1990, Journal of virology.

Molecular Architectures of Trimeric SIV and HIV-1 Envelope Glycoproteins on Intact Viruses: Strain-Dependent Variation in Quaternary Structure

A. Bartesaghi, M. Borgnia, S. Subramaniam, 2010, PLoS pathogens.

Three-Dimensional Structures of Soluble CD4-Bound States of Trimeric Simian Immunodeficiency Virus Envelope Glycoproteins Determined by Using Cryo-Electron Tomography

A. Bartesaghi, M. Borgnia, S. Subramaniam, 2011, Journal of Virology.

Movements of HIV-virions in human cervical mucus.

J. Lifson, R. Nossal, H. Boukari, 2009, Biomacromolecules.

Influence of HLA-C Expression Level on HIV Control

David Heckerman, Jacques Fellay, Simon Mallal, 2013, Science.

Relative Expression Levels of the HLA Class-I Proteins in Normal and HIV-Infected Cells

Ming Zhou, Zhaojing Meng, Richard Apps, 2015, The Journal of Immunology.

Vaccine-induced CD8+ T cells control AIDS virus replication

Todd M. Allen, Aaron M. Seese, T. Allen, 2012, Nature.

Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection

J. Mascola, E. Boritz, T. Chun, 2015, Science Translational Medicine.

Viral dynamics in human immunodeficiency virus type 1 infection

Martin A. Nowak, Sebastian Bonhoeffer, Xiping Wei, 1995, Nature.

Molecular structures of trimeric HIV-1 Env in complex with small antibody derivatives

Erin E. H. Tran, O. Kuybeda, S. Subramaniam, 2012, Proceedings of the National Academy of Sciences.

Noninfectious X4 but Not R5 Human Immunodeficiency Virus Type 1 Virions Inhibit Humoral Immune Responses in Human Lymphoid Tissue Ex Vivo

J. Lifson, A. Sylwester, W. Fitzgerald, 2004, Journal of Virology.

CD4+ T-Lymphocyte Depletion in Human Lymphoid Tissue Ex Vivo Is Not Induced by Noninfectious Human Immunodeficiency Virus Type 1 Virions

J. Lifson, A. Sylwester, W. Fitzgerald, 1998, Journal of Virology.

Vpx is required for dissemination and pathogenesis of SIVSM PBj: Evidence of macrophage-dependent viral amplification

J. Wakefield, J. Lifson, B. Hahn, 1998, Nature Medicine.

Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions

Kenneth A. Taylor, Jun Liu, Kenneth H. Roux, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Prevention of Vaginal SHIV Transmission in Rhesus Macaques Through Inhibition of CCR5

M. Lederman, J. Lifson, M. Piatak, 2004, Science.

A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge

L. Picker, J. Lifson, K. Früh, 2019, Science Translational Medicine.

Polymorphisms in Rhesus Macaque Tetherin Are Associated with Differences in Acute Viremia in Simian Immunodeficiency Virus Δnef-Infected Animals

J. Hoxie, R. Desrosiers, Steven Wolinsky, 2018, Journal of Virology.

Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antiretroviral Therapy.

J. Lifson, G. D. Del Prete, 2018, Current topics in microbiology and immunology.

Balancing Trained Immunity with Persistent Immune Activation and the Risk of Simian Immunodeficiency Virus Infection in Infant Macaques Vaccinated with Attenuated Mycobacterium tuberculosis or Mycobacterium bovis BCG Vaccine

M. Hudgens, W. Jacobs, J. Lifson, 2016, Clinical and Vaccine Immunology.

Evaluation of the safety, immunogenicity, and protective efficacy of whole inactivated simian immunodeficiency virus (SIV) vaccines with conformationally and functionally intact envelope glycoproteins.

J. Lifson, W. Alvord, L. Arthur, 2004, AIDS Research and Human Retroviruses.

The High-Frequency Major Histocompatibility Complex Class I Allele Mamu-B*17 Is Associated with Control of Simian Immunodeficiency Virus SIVmac239 Replication

M. Carrington, D. Watkins, D. O’Connor, 2006, Journal of Virology.

HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism.

J. Lifson, D. Munn, N. Bhardwaj, 2008, The Journal of clinical investigation.

CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis.

J. Lifson, C. Chougnet, J. Grivel, 2005, Blood.

A new theory of cytotoxic T-lymphocyte memory: implications for HIV treatment.

M A Nowak, M. Nowak, D. Wodarz, 2000, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Potent anti-viral activity of a trispecific HIV neutralizing antibody in SHIV-infected monkeys.

J. Mascola, R. Koup, J. Lifson, 2022, Cell reports.

Long-Term Delivery of an Anti-SIV Monoclonal Antibody With AAV

R. Desrosiers, J. Lifson, E. Rakasz, 2020, Frontiers in Immunology.

Adeno‐Associated Virus Delivery of Anti‐HIV Monoclonal Antibodies Can Drive Long‐Term Virologic Suppression

R. Desrosiers, J. Lifson, B. Keele, 2019, Immunity.

Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia

M. Nussenzweig, D. Dimitrov, J. Lifson, 2013, Nature.

A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges

J. Mascola, M. Nussenzweig, J. Lifson, 2016, Nature.

Class-I Proteins in Normal and HIV-Infected Relative Expression Levels of the HLA

M. Carrington, R. Apps, J. Lifson, 2015 .

Monocyte heterogeneity underlying phenotypic changes in monocytes according to SIV disease stage

E. Halpern, J. Lifson, M. McGrath, 2010, Journal of leukocyte biology.

Enhanced antagonism of BST-2 by a neurovirulent SIV envelope.

J. Lifson, Chia-yen Chen, E. Chertova, 2016, The Journal of clinical investigation.

by restoration of CD40/CD154 interactions Failure of HIV-exposed CD4+ T cells to activate dendritic cells is reversed

J. Lifson, C. Chougnet, Rui Zhang, 2013 .

reversed by restoration of CD40/CD154 interactions Failure of HIV-exposed CD4+ T cells to activate dendritic cells is

J. Lifson, C. Chougnet, Rui Zhang, 2013 .

HIV-1 impairs in vitro priming of naïve T cells and gives rise to contact-dependent suppressor T cells

J. Lifson, N. Bhardwaj, E. Shankar, 2010, European journal of immunology.

Gag-Specific CD 8 T Lymphocytes Recognize Infected Cells before AIDS-Virus Integration and Viral Protein Expression 1

D. Watkins, O. Yang, J. Lifson, 2007 .

Gag-Specific CD8+ T Lymphocytes Recognize Infected Cells before AIDS-Virus Integration and Viral Protein Expression1

D. Watkins, O. Yang, J. Lifson, 2007, The Journal of Immunology.

Failure of HIV-exposed CD4+ T cells to activate dendritic cells is reversed by restoration of CD40/CD154 interactions.

J. Lifson, C. Chougnet, Rui Zhang, 2006, Blood.

bloodjournal.hematologylibrary.org at PENN STATE UNIVERSITY on February 20, 2013. For personal use

J. Lifson, C. Chougnet, L. Havekes, 2004 .

CD40 Ligand Dysregulation in HIV Infection: HIV Glycoprotein 120 Inhibits Signaling Cascades Upstream of CD40 Ligand Transcription1

C. Fichtenbaum, J. Lifson, C. Chougnet, 2004, The Journal of Immunology.

Genetically barcoded SIV reveals the emergence of escape mutations in multiple viral lineages during immune escape

Taina T. Immonen, J. Lifson, C. Fennessey, 2019, Proceedings of the National Academy of Sciences.

Capture of antigen-specific T lymphocytes from human blood by selective immortalization to establish long-term T-cell lines maintaining primary cell characteristics.

M. Carrington, J. Lifson, H. Andersen, 2006, Immunology letters.

Sex differences in the Toll-like receptor–mediated response of plasmacytoid dendritic cells to HIV-1

M. Altfeld, M. Carrington, J. Lifson, 2009, Nature Medicine.

2019-03-06 Anti-drug Antibody Responses Impair Prophylaxis Mediated by AAV-Delivered HIV-1 Broadly Neutralizing Antibodies

Barnett, R. Desrosiers, J. Lifson, 2019 .

AAV-delivered eCD4-Ig protects rhesus macaques from high-dose SIVmac239 challenges

J. Lifson, E. Rakasz, M. Farzan, 2019, Science Translational Medicine.

Anti-drug Antibody Responses Impair Prophylaxis Mediated by AAV-Delivered HIV-1 Broadly Neutralizing Antibodies

R. Desrosiers, J. Lifson, M. Farzan, 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity

R. Desrosiers, J. Lifson, M. Piatak, 2015, PLoS pathogens.

Loss of a Tyrosine-Dependent Trafficking Motif in the Simian Immunodeficiency Virus Envelope Cytoplasmic Tail Spares Mucosal CD4 Cells but Does Not Prevent Disease Progression

J. Hoxie, J. Lifson, D. Douek, 2012, Journal of Virology.

The safety and pharmacokinetics of GLQ223 in subjects with AIDS and AIDS-related complex: a phase I study.

J. Kahn, P. Volberding, J. Lifson, 1990, AIDS.

In Vivo Validation of the Viral Barcoding of Simian Immunodeficiency Virus SIVmac239 and the Development of New Barcoded SIV and Subtype B and C Simian-Human Immunodeficiency Viruses

Taina T. Immonen, L. Picker, J. Lifson, 2019, Journal of Virology.

Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections.

J. Lifson, J. Brenchley, G. Silvestri, 2012, Blood.

CD4(81-92)-based peptide derivatives. Structural requirements for blockade of HIV infection, blockade of HIV-induced syncytium formation, and virostatic activity in vitro.

K. M. Hwang, J. Lifson, L. Eiden, 1992, Biochemical pharmacology.

Mucosal Priming of Simian Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Responses in Rhesus Macaques by the Salmonella Type III Secretion Antigen Delivery System

R. Desrosiers, K. Mansfield, J. Lifson, 2003, Journal of Virology.

Blocking of integrins inhibits HIV-1 infection of human cervical mucosa immune cells with free and complement-opsonized virions

J. Lifson, Rada Ellegård, M. Larsson, 2013, European Journal of Immunology.

Infectious and Whole Inactivated Simian Immunodeficiency Viruses Interact Similarly with Primate Dendritic Cells (DCs): Differential Intracellular Fate of Virions in Mature and Immature DCs

J. Lifson, M. Piatak, N. Romani, 2002, Journal of Virology.

Gp120 on HIV-1 Virions Lacks O-Linked Carbohydrate

R. Desrosiers, J. Lifson, J. Bess, 2015, PloS one.

Prevention and treatment of koala retrovirus (KoRV) infection: lessons from studies of AIDS viruses in nonhuman primate models

J. Lifson, 2014 .

Administration of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) for prevention of perinatal simian immunodeficiency virus infection in rhesus macaques.

N. Pedersen, J. Lifson, K. V. Van Rompay, 1998, AIDS research and human retroviruses.

Macaque dendritic cells infected with SIV-recombinant canarypox ex vivo induce SIV-specific immune responses in vivo.

J. Mascola, J. Lifson, M. Eller, 2004, AIDS research and human retroviruses.

Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections.

J. Carlis, J. Lifson, A. Haase, 2011, The Journal of clinical investigation.

Maturation of the HIV-1 core by a non-diffusional phase transition

G. A. Frank, S. Subramaniam, Xiongwu Wu, 2015, Nature Communications.

Trafficking, Persistence, and Activation State of Adoptively Transferred Allogeneic and Autologous Simian Immunodeficiency Virus-Specific CD8+ T Cell Clones during Acute and Chronic Infection of Rhesus Macaques

D. O’Connor, J. Lifson, M. Piatak, 2009, Journal of Immunology.

Characterization and Favorable in Vivo Properties of Heterodimeric Soluble IL-15·IL-15Rα Cytokine Compared to IL-15 Monomer*

J. Lifson, E. Chertova, G. Pavlakis, 2013, The Journal of Biological Chemistry.

Naive T cells are dispensable for memory CD4+ T cell homeostasis in progressive simian immunodeficiency virus infection

L. Picker, J. Lifson, M. Piatak, 2012, The Journal of experimental medicine.

Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes

Taina T. Immonen, J. Mascola, P. Bieniasz, 2019, PLoS pathogens.

A single gp120 residue can affect HIV-1 tropism in macaques

D. Montefiori, P. Bieniasz, J. Lifson, 2017, PLoS pathogens.

Chemical inactivation of retroviral infectivity by targeting nucleocapsid protein zinc fingers: a candidate SIV vaccine.

J. Lifson, L. Arthur, J. Bess, 1998, AIDS research and human retroviruses.

Glycerol monolaurate prevents mucosal SIV transmission

S. Pambuccian, J. Carlis, J. Lifson, 2009, Nature.

Enhanced in vitro stimulation of rhesus macaque dendritic cells for activation of SIV-specific T cell responses.

A. Gettie, J. Lifson, D. Messmer, 2002, Journal of immunological methods.

T-cell responses to KSHV infection: a systematic approach

J. Lifson, D. Douek, C. Fennessey, 2017, Oncotarget.

Impact of early cART in the gut during acute HIV infection.

Jerome H. Kim, R. Dewar, J. Lifson, 2016, JCI insight.

Effector-memory T cell responses are associated with protection of rhesus monkeys from mucosal SIV challenge

L. Picker, J. Lifson, M. Piatak, 2009, Nature Medicine.

of SIV and HIV-1 Sensitive Indicator of Low-Level Replication Inhibitory TCR Coreceptor PD-1 Is a

F. Pereyra, G. Freeman, D. Kaufmann, 2009 .

Short-term Disulfiram to Reverse Latent HIV Infection: A Phase 2 Dose Escalation Study

S. Lewin, J. Lifson, M. Piatak, 2016 .

Macaque Multimeric Soluble CD40 Ligand and GITR Ligand Constructs Are Immunostimulatory Molecules In Vitro

J. Lifson, C. Spina, R. Kornbluth, 2006, Clinical and Vaccine Immunology.

CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption

J. Lifson, D. Margolis, K. Bar, 2020, Nature Medicine.

Nucleocapsid protein zinc-finger mutants of simian immunodeficiency virus strain mne produce virions that are replication defective in vitro and in vivo.

J. Lifson, L. Arthur, R. Gorelick, 1999, Virology.

Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection.

D. Watkins, J. Carlis, L. Picker, 2006, The Journal of infectious diseases.

Topically applied recombinant chemokine analogues fully protect macaques from vaginal simian-human immunodeficiency virus challenge.

M. Lederman, J. Lifson, M. Piatak, 2009, The Journal of infectious diseases.

Nef Enhances Human Immunodeficiency Virus Replication and Responsiveness to Interleukin-2 in Human Lymphoid Tissue Ex Vivo

R. Desrosiers, J. Lifson, P. Meylan, 1999, Journal of Virology.

Vectored delivery of anti-SIV envelope targeting mAb via AAV8 protects rhesus macaques from repeated limiting dose intrarectal swarm SIVsmE660 challenge

J. Mascola, J. Lifson, G. Alter, 2018, PLoS pathogens.

Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus

D. Burton, J. Lifson, Mark G. Lewis, 2016, Science.

Loss of CD103+ DCs and Mucosal IL-17+ and IL-22+ Lymphocytes is Associated with Mucosal Damage in SIV Infection

Y. Belkaid, J. Lifson, J. Brenchley, 2012, Mucosal Immunology.

Rapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus–infected rhesus macaques on antiretroviral therapy

L. Picker, J. Lifson, Y. Fukazawa, 2022, The Journal of clinical investigation.

Host range restricted, non-replicating vaccinia virus vectors as vaccine candidates.

B. Moss, J. Bennink, J. Lifson, 1996, Advances in experimental medicine and biology.

Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques.

C. Deming, D. Hazuda, M. Lederman, 2013, The Journal of clinical investigation.

Characterization of rhesus macaque natural killer activity against a rhesus-derived target cell line at the single-cell level.

M. Carrington, J. Lifson, H. Andersen, 2004, Cellular immunology.

Balancing trained immunity with persistent immune activation and the risk of SIV infection in infant macaques vaccinated with attenuated Mycobacterium tuberculosis or BCG vaccines

W. Jacobs, J. Lifson, M. Piatak, 2016 .

CD4 antigen-based antireceptor peptides inhibit infectivity of human immunodeficiency virus in vitro at multiple stages of the viral life cycle.

K. M. Hwang, J. Lifson, L. Eiden, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Synthetic CD4 peptide derivatives that inhibit HIV infection and cytopathicity.

K. M. Hwang, J. Lifson, L. Eiden, 1988, Science.

Contribution of CD8 (cid:1) T Cells to Containment of Viral Replication and Emergence of Mutations in Mamu-A * 01 -Restricted Epitopes in Simian Immunodeﬁciency Virus-Infected Rhesus Monkeys (cid:1) †

Steven Wolinsky, J. Lifson, J. Schmitz, 2008 .

AIDS vaccines: One step forwards, one step back

J. Lifson, Malcolma . Martin, 2002, Nature.

HSV-2-Driven Increase in the Expression of α4β7 Correlates with Increased Susceptibility to Vaginal SHIVSF162P3 Infection

A. Gettie, J. Blanchard, J. Lifson, 2014, PLoS pathogens.

The Frequency of &agr;4&bgr;7high Memory CD4+ T Cells Correlates With Susceptibility to Rectal Simian Immunodeficiency Virus Infection

A. Gettie, J. Blanchard, J. Lifson, 2013, Journal of acquired immune deficiency syndromes.

The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription

L. Picker, J. Lifson, L. Trautmann, 2022, PLoS pathogens.

Recombinant modified vaccinia virus Ankara provides durable protection against disease caused by an immunodeficiency virus as well as long-term immunity to an orthopoxvirus in a non-human primate.

P. Earl, B. Moss, D. Montefiori, 2007, Virology.

Dynamics of Simian immunodeficiency virus‐specific cytotoxic T‐cell responses in tissues

J. Blanchard, J. Lifson, J. Schmitz, 2003, Journal of medical primatology.

CD8 lymphocyte depletion enhances the latency reversal activity of the SMAC mimetic AZD5582 in ART-suppressed SIV-infected rhesus macaques

A. Perelson, J. Lifson, R. Ke, 2021 .

Virus-Specific T Cells -Secreting Simian Immunodeficiency γto Augment the Activation of IFN- Plasmacytoid Dendritic Cells in Rhesus Oligodeoxyribonucleotide Activation of CpG-C Immunostimulatory

A. Gettie, J. Lifson, Jennifer Jones, 2013 .

CpG-C Immunostimulatory Oligodeoxyribonucleotide Activation of Plasmacytoid Dendritic Cells in Rhesus Macaques to Augment the Activation of IFN-γ-Secreting Simian Immunodeficiency Virus-Specific T Cells1

A. Gettie, J. Lifson, Jennifer Jones, 2004, The Journal of Immunology.

Evidence of dysregulation of dendritic cells in primary HIV infection

K. Shianna, J. Fellay, M. Markowitz, 2010, Blood.

Antiviral Studies with Trichosanthin, A Plant Derived Single Chain Ribosome Inactivating Protein

J. Lifson, M. McGrath, M. Piatak, 1992 .

Evaluation of immune responses induced by HIV-1 gp120 in rhesus macaques: effect of vaccination on challenge with pathogenic strains of homologous and heterologous simian human immunodeficiency viruses.

J. Lifson, O. Narayan, P. Silverstein, 2000, Virology.

The Major Histocompatibility Complex Class II Alleles Mamu - DRB1 * 1003 and -DRB1 * 0306 Are Enriched in a Cohort of Simian Immunodeﬁciency Virus-Infected Rhesus Macaque Elite Controllers (cid:1)

M. Carrington, Y. Qi, D. Watkins, 2007 .

Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells

J. Goedert, M. Carrington, B. Walker, 2018, Science.

Specific CD8+ T Cell Responses Correlate with Control of Simian Immunodeficiency Virus Replication in Mauritian Cynomolgus Macaques

Melisa L. Budde, D. O’Connor, J. Lifson, 2012, Journal of Virology.

Inactivated Simian Immunodeficiency Virus-Pulsed Autologous Fresh Blood Cells as an Immunotherapy Strategy

J. Lifson, L. Loh, S. Alcântara, 2008, Journal of Virology.

The High-Frequency Major Histocompatibility Complex (MHC) Class I Allele Mamu-B*17 Is Associated with Control of Simian Immunodeficiency Virus SIVmac239 Replication

M. Carrington, D. Watkins, D. O’Connor, 2006, Journal of Virology.

Defining early SIV replication and dissemination dynamics following vaginal transmission

Taina T. Immonen, J. Lifson, C. Fennessey, 2019, Science Advances.

Increased CD4+ T Cell Levels during IL-7 Administration of Antiretroviral Therapy-Treated Simian Immunodeficiency Virus-Positive Macaques Are Not Dependent on Strong Proliferative Responses

L. Picker, J. Lifson, B. Assouline, 2010, Journal of Immunology.

Strong Proliferative Responses Virus-Positive Macaques Are Not Dependent Therapy-Treated Simian Immunodeficiency Administration of Antiretroviral T Cell Levels during IL-7 + Increased CD 4

L. Picker, J. Lifson, B. Assouline, 2010 .

MHC-I–restricted presentation of HIV-1 virion antigens without viral replication

J. Lifson, L. Arthur, J. Abastado, 2001, Nature Medicine.

Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation and IL-17 production in the absence of SIV infection

J. Lifson, J. Brenchley, A. Levine, 2010, Mucosal Immunology.

Polymorphisms in interferon regulatory factor 7 reduce interferon-α responses of plasmacytoid dendritic cells to HIV-1

M. Altfeld, M. Carrington, J. Lifson, 2011, AIDS.

PrimatesInduced T Cell Responses In Nonhuman Effective TLR Adjuvant for SIV Gag Protein Polyinosinic-Polycytidylic Acid Is the Most

L. Picker, J. Lifson, M. Piatak, 2013 .

Exposure to HIV-1-encoded Toll-like receptor 8 ligands enhances monocyte response to microbial encoded Toll-like receptor 2/4 ligands

M. Altfeld, T. Ndung’u, J. Lifson, 2010, AIDS.

Ex vivo production of autologous whole inactivated HIV-1 for clinical use in therapeutic vaccines.

B. Clotet, J. Martinez-Picado, C. Brander, 2011, Vaccine.

Effect of combination antiretroviral therapy on Chinese rhesus macaques of simian immunodeficiency virus infection.

J. Lifson, M. Piatak, B. Ling, 2013, AIDS Research and Human Retroviruses.

Preclinical evaluation of HIV eradication strategies in the simian immunodeficiency virus-infected rhesus macaque: a pilot study testing inhibition of indoleamine 2,3-dioxygenase.

J. Lifson, J. McCune, M. Piatak, 2012, AIDS research and human retroviruses.

Location and Dynamics of the Immunodominant CD8 T Cell Response to SIVΔnef Immunization and SIVmac251 Vaginal Challenge

J. Lifson, A. Haase, R. Johnson, 2013, PloS one.

Response : HIV and AIDS

Michael A. Piatak, J. Lifson, G. Shaw, 1993, Science.

Role of IL-15 Signaling in the Pathogenesis of Simian Immunodeficiency Virus Infection in Rhesus Macaques

L. Picker, J. Lifson, Y. Fukazawa, 2019, The Journal of Immunology.

PD-1 Blockade and TLR7 Activation Lack Therapeutic Benefit in Chronic Simian Immunodeficiency Virus-Infected Macaques on Antiretroviral Therapy

J. Lifson, B. Carr, R. Geleziunas, 2019, Antimicrobial Agents and Chemotherapy.

Control of Heterologous SIVsmE660 infection by DNA and Protein Co-immunization Regimens Combined with Different Toll-like Receptor-4 (TLR-4) Based Adjuvants in Macaques

Margherita, N. Sardesai, D. Montefiori, 2018 .

Truncating the Gp41 Cytoplasmic Tail of SIV Decreases Sensitivity to 1 Neutralizing Antibodies without Increasing Envelope Content of 2 Virions 3

J. Lifson, J. Bess, E. Chertova, 2017 .

Autologous aldrithiol-2-inactivated HIV-1 combined with polyinosinic-polycytidylic acid-poly-L-lysine carboxymethylcellulose as a vaccine platform for therapeutic dendritic cell immunotherapy.

J. Lifson, J. Bess, N. Bhardwaj, 2015, Vaccine.

Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART

J. Lifson, M. Gale, G. Silvestri, 2018, PLoS pathogens.

Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques.

J. Lifson, J. Brenchley, K. Ladell, 2010, Blood.

Mechanisms underlying (cid:1)(cid:2) T-cell subset perturbations in SIV-infected Asian rhesus macaques

J. Lifson, J. Brenchley, K. Ladell, 2010 .

HIV-1–induced AIDS in monkeys

P. Bieniasz, J. Lifson, B. Keele, 2014, Science.

Increased Loss of CCR5 (cid:1) CD45RA (cid:2) CD4 (cid:1) T Cells in CD8 (cid:1) Lymphocyte-Depleted Simian Immunodeﬁciency Virus-Infected Rhesus Monkeys (cid:1)

D. Montefiori, Steven Wolinsky, J. Lifson, 2022 .

Low-level alternative tRNA priming of reverse transcription of HIV-1 and SIV in vivo

Taina T. Immonen, J. Lifson, C. Fennessey, 2019, Retrovirology.

Antifibrotic therapy in simian immunodeficiency virus infection preserves CD4+ T-cell populations and improves immune reconstitution with antiretroviral therapy.

A. Berglund, J. Lifson, A. Haase, 2015, The Journal of infectious diseases.

Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV‐1

B. Walker, J. Lifson, N. Bhardwaj, 2007, European journal of immunology.

Evidence by peptide mapping that the region CD4(81-92) is involved in gp120/CD4 interaction leading to HIV infection and HIV-induced syncytium formation.

K. M. Hwang, J. Lifson, L. Eiden, 1990, Journal of immunology.

UC Office of the President Recent Work Title The immunologic effects of mesalamine in treated HIV-infected individuals with incomplete CD 4 + T cell recovery : a randomized crossover trial

Jeffrey N. Martin, J. Lifson, J. McCune, 2014 .

Determination of plasma viral load in HIV‐1 infection by quantitative competitive polymerase chain reaction

S. J. Clark, J. Kappes, J. Lifson, 1993, AIDS.

Human immunodeficiency virus-infected monocyte-derived macrophages express surface gp120 and fuse with CD4 lymphoid cells in vitro: a possible mechanism of T lymphocyte depletion in vivo.

J. Lifson, T. Elbeik, M. McGrath, 1992, Clinical immunology and immunopathology.

SIV Vpx Is Essential for Macrophage Infection but Not for Development of AIDS

R. Desrosiers, K. Mansfield, J. Lifson, 2014, PloS one.

rhIL-15 and anti-PD-L1 combination therapy expands a CXCR3+PD1-/low CD8 T cell subset in SIV-infected rhesus macaques.

H. Lane, J. Lifson, Ping Chen, 2019, The Journal of infectious diseases.

Reduced inflammation and lymphoid tissue immunopathology in rhesus macaques receiving anti-tumor necrosis factor treatment during primary simian immunodeficiency virus infection.

Octavio A. Quiñones, J. Lifson, J. Brenchley, 2013, The Journal of infectious diseases.

Limited impact of fingolimod treatment during the initial weeks of ART in SIV-infected rhesus macaques

M. Lederman, J. Lifson, M. Betts, 2022, Nature Communications.

Role of envelope glycoprotein carbohydrate in human immunodeficiency virus (HIV) infectivity and virus-induced cell fusion

J. Lifson, E. Engleman, S. Coutre, 1986, The Journal of experimental medicine.

Toll-like receptor 7-adapter complex modulates interferon-α production in HIV-stimulated plasmacytoid dendritic cells

S. Migueles, M. Connors, J. Lifson, 2019, PloS one.

CD40 Ligand Dysregulation in HIV Infection: HIV Glycoprotein 120 Inhibits Signaling Cascades Upstream of CD40 Ligand Transcription1

C. Fichtenbaum, J. Lifson, C. Chougnet, 2004, The Journal of Immunology.

TranscriptionCascades Upstream of CD40 Ligand HIV Glycoprotein 120 Inhibits Signaling CD40 Ligand Dysregulation in HIV Infection:

C. Fichtenbaum, J. Lifson, C. Chougnet, 2004 .

Protection of Macaca nemestrina from Disease following Pathogenic Simian Immunodeficiency Virus (SIV) Challenge: Utilization of SIV Nucleocapsid Mutant DNA Vaccines with and without an SIV Protein Boost

B. M. Flynn, J. Lifson, L. Arthur, 2000, Journal of Virology.

Pembrolizumab induces HIV latency reversal in people living with HIV and cancer on antiretroviral therapy

S. Lewin, J. Lifson, R. Sékaly, 2022, Science Translational Medicine.

The Use of Nonhuman Primate Models in HIV Vaccine Development

N. Haigwood, C. Cheng‐Mayer, John P. Moore, 2008, PLoS medicine.

Antiretroviral Therapy in Simian Immunodeficiency Virus-Infected Sooty Mangabeys: Implications for AIDS Pathogenesis

J. Lifson, B. Keele, D. Carnathan, 2016, Journal of Virology.

The class II MHC and HIV-1 binding surfaces of CD4.

J. Lifson, L. Eiden, 1993, Trends in microbiology.

Synthetic peptides allow discrimination of structural features of CD4(81-92) important for HIV-1 infection versus HIV-1-induced syncytium formation.

K. M. Hwang, J. Lifson, L. Eiden, 1991, AIDS research and human retroviruses.

SMAC Mimetic Plus Triple-Combination Bispecific HIVxCD3 Retargeting Molecules in SHIV.C.CH505-Infected, Antiretroviral Therapy-Suppressed Rhesus Macaques

J. Lifson, G. Shaw, N. Schoof, 2020, Journal of Virology.

Tetherin Upregulation in Simian Immunodeficiency Virus-Infected Macaques

J. Lifson, M. Piatak, C. Midkiff, 2013, Journal of Virology.

Partial efficacy of a broadly neutralizing antibody against cell-associated SHIV infection

D. Montefiori, J. Lifson, R. Center, 2017, Science Translational Medicine.

HIV interactions with CD4: a continuum of conformations and consequences.

J. Lifson, L. Eiden, Lee E. Eiden, 1992, Immunology today.

Fusion of human immunodeficiency virus-infected cells with uninfected cells.

J. Lifson, 1993, Methods in enzymology.

Local and Systemic Effects of Intranodally Injected CpG-C Immunostimulatory-Oligodeoxyribonucleotides in Macaques1

A. Gettie, J. Lifson, I. Sivin, 2006, The Journal of Immunology.

pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane

Edgar G. Engleman, Barry S. Stein, J. Lifson, 1987, Cell.

Concordance of immunological events between intrarectal and intravenous SHIVAD8-EO infection when assessed by Fiebig-equivalent staging.

J. Mascola, R. Koup, J. Lifson, 2021, The Journal of clinical investigation.

Purified interleukin-2 induces proliferation of fresh human lymphocytes in the absence of exogenous stimuli.

A. Raubitschek, J. Lifson, E. Engleman, 1986, Journal of biological response modifiers.

Erratum: Progressive CD4+ central-memory T cell decline results in CD4+ effector-memory insufficiency and overt disease in chronic SIV infection (Journal of Experimental Medicine (September 3, 2007) 204, 9, (2171-2185))

Z. Grossman, M. Meier-Schellersheim, V. Maino, 2007 .

Insufficient Production and Tissue Delivery of CD4+Memory T Cells in Rapidly Progressive Simian Immunodeficiency Virus Infection

V. Maino, L. Picker, J. Lifson, 2004, The Journal of experimental medicine.

A cellular trafficking signal in the SIV envelope protein cytoplasmic domain is strongly selected for in pathogenic infection

J. Hoxie, D. O’Connor, J. Lifson, 2022, PLoS pathogens.

A Modified Zinc Acetate Gel, a Potential Nonantiretroviral Microbicide, Is Safe and Effective against Simian-Human Immunodeficiency Virus and Herpes Simplex Virus 2 Infection In Vivo

A. Gettie, J. Blanchard, J. Lifson, 2013, Antimicrobial Agents and Chemotherapy.

Nucleic Acid, Antibody, and Virus Culture Methods to Detect Xenotropic MLV-Related Virus in Human Blood Samples

W. Linehan, C. Vocke, V. Pathak, 2011, Advances in virology.

Immunotherapy with DNA vaccine and live attenuated rubella/SIV gag vectors plus early ART can prevent SIVmac251 viral rebound in acutely infected rhesus macaques

J. Lifson, Mark G. Lewis, I. Berkower, 2020, PloS one.

Ultrasensitive Immunoassay for Simian Immunodeficiency Virus p27

J. Lifson, B. Keele, R. Gorelick, 2018 .

Characterization and epitope mapping of a human monoclonal antibody reactive with the envelope glycoprotein of human immunodeficiency virus.

J. Lifson, E. Engleman, L. Young, 1987, Journal of immunology.

Effect of Derivatized Nucleotide Antiviral Drugs on HIV‐1 Replication in Cells of T‐Lymphoblastoid and Monocyte/Macrophage Lineage in Vitro a

J. Lifson, M. McGrath, M. Dawson, 1990 .

Stimulation of glycoprotein gp120 dissociation from the envelope glycoprotein complex of human immunodeficiency virus type 1 by soluble CD4 and CD4 peptide derivatives: implications for the role of the complementarity-determining region 3-like region in membrane fusion.

J. Lifson, L. Eiden, E. Berger, 1991, Proceedings of the National Academy of Sciences of the United States of America.

The nonnucleoside reverse transcription inhibitor MIV-160 delivered from an intravaginal ring, but not from a carrageenan gel, protects against simian/human immunodeficiency virus-RT Infection.

A. Gettie, J. Blanchard, J. Lifson, 2012, AIDS research and human retroviruses.

Transmission in Macaques An Intravaginal Ring That Releases the NNRTI MIV-150 Reduces SHIV

A. Gettie, J. Blanchard, J. Lifson, 2012 .

Short Communication: Comparative Evaluation of Coformulated Injectable Combination Antiretroviral Therapy Regimens in Simian Immunodeficiency Virus-Infected Rhesus Macaques.

J. Lifson, B. Keele, M. Piatak, 2016, AIDS research and human retroviruses.

Safety, activity, and pharmacokinetics of GLQ223 in patients with AIDS and AIDS-related complex

J. Kahn, J. Lifson, A. Bostrom, 1994, Antimicrobial Agents and Chemotherapy.

Cryo-EM structures of prefusion SIV envelope trimer

J. Lifson, B. Keele, M. Roederer, 2022, Nature Structural & Molecular Biology.

J. Lifson, C. Chougnet, J. Grivel, 2005, Blood.

Dolutegravir Monotherapy of Simian Immunodeficiency Virus-Infected Macaques Selects for Several Patterns of Resistance Mutations with Variable Virological Outcomes

M. Wainberg, J. Lifson, B. Keele, 2018, Journal of Virology.

Defining HIV and SIV Reservoirs in Lymphoid Tissues

J. Lifson, A. Haase, J. McCune, 2016, Pathogens & immunity.

the Path of Virus Entry Antibody Production and Concentration on Vaccine Correlate of Protection: Local Live Simian Immunodeficiency Virus

J. Robinson, S. Pambuccian, J. Carlis, 2014 .

Asymmetric HIV-1 envelope trimers bound to one and two CD4 molecules are intermediates during membrane binding

H. Tagare, J. Lifson, P. Uchil, 2022, bioRxiv.

Envelope Glycoprotein Incorporation, Not Shedding of Surface Envelope Glycoprotein (gp120/SU), Is the Primary Determinant of SU Content of Purified Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus

J. Hoxie, J. Lifson, L. Arthur, 2002, Journal of Virology.

type I interferon-dependent, TRAIL/DR5-mediated apoptosis CD4+ T cell death induced by infectious and noninfectious HIV-1: role of

J. Lifson, C. Chougnet, J. Grivel, 2013 .

Human Immunodeficiency Virus Type 1 Activates Plasmacytoid Dendritic Cells and Concomitantly Induces the Bystander Maturation of Myeloid Dendritic Cells

J. Lifson, D. Littman, N. Bhardwaj, 2004, Journal of Virology.

Intrinsic Susceptibility of Rhesus Macaque Peripheral CD4+ T Cells to Simian Immunodeficiency Virus In Vitro Is Predictive of In Vivo Viral Replication

J. Lifson, Charles R. Brown, V. Hirsch, 2000, Journal of Virology.

Induction of Transient Virus Replication Facilitates Antigen-Independent Isolation of SIV-Specific Monoclonal Antibodies

D. Burton, D. Watkins, J. Lifson, 2020, Molecular therapy. Methods & clinical development.

Vaccine protection against SIVmac239 acquisition

D. Watkins, R. Desrosiers, J. Lifson, 2019, Proceedings of the National Academy of Sciences.

The Frequency of Vaccine-Induced T-Cell Responses Does Not Predict the Rate of Acquisition after Repeated Intrarectal SIVmac239 Challenges in Mamu-B*08+ Rhesus Macaques

D. Watkins, R. Desrosiers, J. Lifson, 2018, Journal of Virology.

Mamu-B*17+ Rhesus Macaques Vaccinated with env, vif, and nef Manifest Early Control of SIVmac239 Replication

Todd M. Allen, D. Burton, D. Watkins, 2018, Journal of Virology.

Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques

D. Burton, D. Watkins, R. Desrosiers, 2017, PLoS pathogens.

Viral dynamics of primary viremia and antiretroviral therapy in simian immunodeficiency virus infection

L M Wahl, M A Nowak, A L Lloyd, 1997, Journal of virology.

Roles of substrate availability and infection of resting and activated CD4+ T cells in transmission and acute simian immunodeficiency virus infection.

Qingsheng Li, Lijie Duan, Stephen W Wietgrefe, 2004, Proceedings of the National Academy of Sciences of the United States of America.

HIV-1 Vpu Mediates HLA-C Downregulation.

M. Carrington, B. Walker, R. Apps, 2016, Cell host & microbe.

Liebensteiner of Biotic and Abiotic Reactions Archaeal ( Per ) Chlorate Reduction at High Temperature : An Interplay

J. Goedert, M. Carrington, Y. Qi, 2014 .

Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells.

J. Lifson, M. Piatak, A. Cunningham, 2004, Blood.

Transmission of lymphadenopathy-associated virus/human T lymphotropic virus type III in sexual partners. Seropositivity does not predict infectivity in all cases.

F. Brun-Vézinet, J. Lifson, J. Chermann, 1986, The American journal of medicine.

HUMAN RECOMBINANT INTERLEUKIN-2 PARTLY RECONSTITUTES DEFICIENT IN-VITRO IMMUNE RESPONSES OF LYMPHOCYTES FROM PATIENTS WITH AIDS

J. Lifson, C. Benike, K. Koths, 1984, The Lancet.

Mucosal Humoral Immune Response to SIVmac239∆nef Vaccination and Vaginal Challenge

J. Carlis, J. Lifson, A. Haase, 2016, The Journal of Immunology.

Live Simian Immunodeficiency Virus Vaccine Correlate of Protection: Local Antibody Production and Concentration on the Path of Virus Entry

D. Burton, S. Pambuccian, J. Carlis, 2014, The Journal of Immunology.

Candida albicans-Induced DC Activation Partially Restricts HIV Amplification in DCs and Increases DC to T-Cell Spread of HIV

J. Lifson, J. Bess, L. Vachot, 2008, Journal of acquired immune deficiency syndromes.

Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection

P. Choyke, J. Lifson, J. Brenchley, 2015, Nature Communications.

Proteomic and Biochemical Analysis of Purified Human Immunodeficiency Virus Type 1 Produced from Infected Monocyte-Derived Macrophages

K. Nagashima, T. Veenstra, J. Lifson, 2006, Journal of Virology.

A Dendritic Cell–Based Vaccine Elicits T Cell Responses Associated with Control of HIV-1 Replication

B. Clotet, J. Martinez-Picado, B. Autran, 2013, Science Translational Medicine.

HIV-1 infection induces strong production of IP-10 through TLR7/9-dependent pathways

D. Lauffenburger, E. Rosenberg, M. Altfeld, 2013, AIDS.

AIDS retrovirus induced cytopathology: giant cell formation and involvement of CD4 antigen.

J. Lifson, M. McGrath, G. Reyes, 1986, Science.

Lessons in nonhuman primate models for AIDS vaccine research: from minefields to milestones.

N. Haigwood, J. Lifson, 2012, Cold Spring Harbor perspectives in medicine.

Activation of HIV-1 specific CD4 and CD8 T cells by human dendritic cells: roles for cross-presentation and non-infectious HIV-1 virus

J. Lifson, P. Haslett, N. Bhardwaj, 2002, AIDS.

SIVmac251 is inefficiently transmitted to rhesus macaques by penile inoculation with a single SIVenv variant found in ramp-up phase plasma.

J. Lifson, B. Keele, L. Fritts, 2011, AIDS research and human retroviruses.

The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection

M. Nowak, A. Lloyd, A. Fauci, 1997, Journal of virology.

Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)-infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara

B. Moss, D. Montefiori, J. Lifson, 1996, Journal of virology.

High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR.

S. J. Clark, J. Kappes, J. Lifson, 1993, Science.

Quantitative competitive polymerase chain reaction for accurate quantitation of HIV DNA and RNA species.

J. Lifson, B. Williams, M. Piatak, 1993, BioTechniques.

Experimental Oral Herpes Simplex Virus-1 (HSV-1) Co-infection in Simian Immunodeficiency Virus (SIV)-Infected Rhesus Macaques

Moriah L. Szpara, A. Gettie, J. Blanchard, 2017, Front. Microbiol..

Short communication: a repeated simian human immunodeficiency virus reverse transcriptase/herpes simplex virus type 2 cochallenge macaque model for the evaluation of microbicides.

A. Gettie, J. Blanchard, J. Lifson, 2014, AIDS research and human retroviruses.

Efficacy of Carraguard®-Based Microbicides In Vivo Despite Variable In Vitro Activity

A. Gettie, J. Blanchard, J. Lifson, 2008, PloS one.

Differential Incorporation of CD45, CD80 (B7-1), CD86 (B7-2), and Major Histocompatibility Complex Class I and II Molecules into Human Immunodeficiency Virus Type 1 Virions and Microvesicles: Implications for Viral Pathogenesis and Immune Regulation

J. Lifson, L. Arthur, J. Bess, 2001, Journal of Virology.

Immune clearance of highly pathogenic SIV infection

Matthew S. Lewis, L. Picker, J. Lifson, 2013, Nature.

Profound early control of highly pathogenic SIV by an effector-memory T cell vaccine

Matthew S. Lewis, L. Picker, J. Lifson, 2011, Nature.

High Viral Load in the Cerebrospinal Fluid and Brain Correlates with Severity of Simian Immunodeficiency Virus Encephalitis

J. Clements, J. Lifson, M. Zink, 1999, Journal of Virology.

A macaque model of HIV-1 infection

Ronald S Veazey, P. Bieniasz, J. Lifson, 2009, Proceedings of the National Academy of Sciences.

Effect of CD8+ Lymphocyte Depletion on Virus Containment after Simian Immunodeficiency Virus SIVmac251 Challenge of Live Attenuated SIVmac239Δ3-Vaccinated Rhesus Macaques

D. Montefiori, R. Desrosiers, R. Gelman, 2005, Journal of Virology.

Containment of Simian Immunodeficiency Virus Infection: Cellular Immune Responses and Protection from Rechallenge following Transient Postinoculation Antiretroviral Treatment

B. M. Flynn, M. Nowak, D. Wodarz, 2000, Journal of Virology.

Efficacy of a SHIV 89.6 proviral DNA vaccine against mucosal SIVmac239 challenge.

J. Lifson, M. Busch, K. Abel, 2005, Vaccine.

Comparison of virology and immunology in SHIV 89.6 proviral DNA and virus‐inoculated rhesus macaques

J. Lifson, M. Busch, L. Fritts, 2003, Journal of medical primatology.

Effective Induction of Simian Immunodeficiency Virus-Specific Systemic and Mucosal Immune Responses in Primates by Vaccination with Proviral DNA Producing Intact but Noninfectious Virions

D. Montefiori, J. Lifson, R. Johnson, 2000, Journal of Virology.

Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein

K. Steimer, B. Moss, S. Chakrabarti, 1986, Nature.

Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV‐1 Transcription in a Phase IIb Trial

S. Lewin, J. Lifson, P. Bacchetti, 2018, Clinical pharmacology and therapeutics.

CpG Oligodeoxynucleotides Protect Normal and SIV-Infected Macaques from Leishmania Infection1

J. Lifson, Shuying Liu, D. Klinman, 2003, The Journal of Immunology.

Simian immunodeficiency virus-induced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infection.

J. Carlis, J. Lifson, A. Haase, 2007, The Journal of infectious diseases.

Expression of PD‐L1 and PD‐L2 on human macrophages is up‐regulated by HIV‐1 and differentially modulated by IL‐10

B. Walker, G. Freeman, D. Kaufmann, 2011, Journal of leukocyte biology.

CD8(+) Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy.

J. Lifson, Kirk A Easley, G. Silvestri, 2016, Immunity.

Effective treatment of SIVcpz-induced immunodeficiency in a captive western chimpanzee

G. Learn, P. Sharp, J. Lifson, 2017, Retrovirology.

Molecular Cloning and Disease Association of Hepatitis G Virus: A Transfusion-Transmissible Agent

H. Margolis, M. Alter, J. Lifson, 1996, Science.

Double-Stranded RNA Analog Poly(I:C) Inhibits Human Immunodeficiency Virus Amplification in Dendritic Cells via Type I Interferon-Mediated Activation of APOBEC3G

J. Lifson, J. Bess, S. Turville, 2008, Journal of Virology.

HSV-2 Infection of Dendritic Cells Amplifies a Highly Susceptible HIV-1 Cell Target

A. Gettie, J. Blanchard, J. Lifson, 2011, PLoS pathogens.

CpG oligodeoxynucleotides improve the response to hepatitis B immunization in healthy and SIV-infected rhesus macaques

J. Lifson, D. Klinman, D. Verthelyi, 2004, AIDS.

Effectiveness of Postinoculation (R)-9-(2-Phosphonylmethoxypropyl)Adenine Treatment for Prevention of Persistent Simian Immunodeficiency Virus SIVmne Infection Depends Critically on Timing of Initiation and Duration of Treatment

J. Lifson, K. E. Follis, R. Benveniste, 1998, Journal of Virology.

Determinants of Increased Replicative Capacity of Serially Passaged Simian Immunodeficiency Virus with nef Deleted in Rhesus Monkeys

R. Means, R. Desrosiers, K. Mansfield, 2003, Journal of Virology.

Real-time polymerase chain reaction assay for cell-associated HTLV type I DNA viral load.

J. Lifson, S. Jacobson, A. Manns, 2000, AIDS research and human retroviruses.

International AIDS Society global scientific strategy: towards an HIV cure 2016

Richard Jefferys, David Margolis, Jintanat Ananworanich, 2016, Nature Medicine.

Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus.

R. Desrosiers, J. Lifson, R. Bronson, 2007, Virology.

The central nervous system as a reservoir for simian immunodeficiency virus (SIV): steady-state levels of SIV DNA in brain from acute through asymptomatic infection.

J. Clements, J. Lifson, M. Zink, 2002, The Journal of infectious diseases.

Clinical evaluation of branched DNA signal amplification for quantifying HIV type 1 in human plasma.

D. Ho, Y. Cao, J. Lifson, 1995, AIDS research and human retroviruses.

Exposure to SIV in utero results in reduced viral loads and altered responsiveness to postnatal challenge

J. Lifson, J. McCune, D. Hartigan-O’Connor, 2015, Science Translational Medicine.

An intravaginal ring that releases three antiviral agents and a contraceptive blocks SHIV-RT infection, reduces HSV-2 shedding, and suppresses hormonal cycling in rhesus macaques

A. Gettie, J. Blanchard, J. Lifson, 2017, Drug Delivery and Translational Research.

Myeloid cell tropism enables MHC-E–restricted CD8+ T cell priming and vaccine efficacy by the RhCMV/SIV vaccine

L. Picker, J. Lifson, K. Früh, 2022, Science Immunology.

Inactivation of Human Immunodeficiency Virus Type 1 Infectivity with Preservation of Conformational and Functional Integrity of Virion Surface Proteins

Q. Sattentau, J. Lifson, L. Arthur, 1998, Journal of Virology.

Mucosal immune stimulation with HSV-2 and polyICLC boosts control of viremia in SIVΔNef vaccinated rhesus macaques with breakthrough SIV infection

A. Gettie, J. Blanchard, J. Lifson, 2020, bioRxiv.

PolyICLC Exerts Pro- and Anti-HIV Effects on the DC-T Cell Milieu In Vitro and In Vivo

A. Gettie, J. Blanchard, J. Lifson, 2016, PloS one.

Plasma SIV RNA viral load determination by real-time quantification of product generation in reverse transcriptase-polymerase chain reaction.

J. Lifson, V. Hirsch, T. Wiltrout, 1998, AIDS research and human retroviruses.

Cytomegalovirus-vaccine-induced unconventional T cell priming and control of SIV replication is conserved between primate species.

Leanne S. Whitmore, L. Picker, J. Lifson, 2022, Cell host & microbe.

Interleukin-15 response signature predicts RhCMV/SIV vaccine efficacy

Leanne S. Whitmore, Xinxia Peng, J. Komorowski, 2021, PLoS pathogens.

Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy

L. Picker, J. Lifson, K. Früh, 2020, Science.

Cytomegaloviral determinants of CD8+ T cell programming and RhCMV/SIV vaccine efficacy

L. Picker, J. Lifson, K. Früh, 2020, Science Immunology.

Addendum: Immune clearance of highly pathogenic SIV infection

Matthew S. Lewis, L. Picker, J. Lifson, 2017, Nature.

Cytomegalovirus Vectors Violate CD8+ T Cell Epitope Recognition Paradigms

Matthew S. Lewis, L. Picker, J. Lifson, 2013, Science.

The Journal of Experimental Medicine

Z. Grossman, M. Meier-Schellersheim, P. Marrack, 2000 .

complex.in patients with AIDS and AIDS-related Safety, activity, and pharmacokinetics of

J. Lifson, A. Bostrom, K. Gorelick, 2013 .

Felipe García Control of HIV-1 Replication Based Vaccine Elicits T Cell Responses Associated with − A Dendritic Cell

Felipe García, Brigitte Autran, Agathe León, 2012 .

A Fusion Inhibitor Prevents Spread of Immunodeficiency Viruses, but Not Activation of Virus-Specific T Cells, by Dendritic Cells

A. Gettie, J. Lifson, J. Bess, 2008, Journal of Virology.

Strict conservation of the retroviral nucleocapsid protein zinc finger is strongly influenced by its role in viral infection processes: characterization of HIV-1 particles containing mutant nucleocapsid zinc-coordinating sequences.

J. Lifson, L. Arthur, R. Gorelick, 1999, Virology.

Impact of Nef-Mediated Downregulation of Major Histocompatibility Complex Class I on Immune Response to Simian Immunodeficiency Virus

R. Desrosiers, K. Mansfield, J. Lifson, 2004, Journal of Virology.

Magnitude and Quality of Cytokine and Chemokine Storm during Acute Infection Distinguish Nonprogressive and Progressive Simian Immunodeficiency Virus Infections of Nonhuman Primates

Norman L. Letvin, Persephone Borrow, Nicola Ternette, 2016, Journal of Virology.

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

Baoshan Zhang, Peter D. Kwong, Michael S. Seaman, 2015, Nature.

Quantitation of HLA Class II Protein Incorporated into Human Immunodeficiency Type 1 Virions Purified by Anti-CD45 Immunoaffinity Depletion of Microvesicles

K. Nagashima, J. Lifson, E. Chertova, 2003, Journal of Virology.

Highly sensitive SIV plasma viral load assay: practical considerations, realistic performance expectations, and application to reverse engineering of vaccines for AIDS

J. Lifson, M. Piatak, J. Bess, 2005, Journal of medical primatology.

Truncating the gp41 Cytoplasmic Tail of Simian Immunodeficiency Virus Decreases Sensitivity to Neutralizing Antibodies without Increasing the Envelope Content of Virions

J. Lifson, J. Bess, E. White, 2017, Journal of Virology.

Identification of the ancestral killer immunoglobulin-like receptor gene in primates

M. Carrington, P. Coggill, S. Beck, 2006, BMC Genomics.

The Major Histocompatibility Complex Class II Alleles Mamu-DRB1*1003 and -DRB1*0306 Are Enriched in a Cohort of Simian Immunodeficiency Virus-Infected Rhesus Macaque Elite Controllers

M. Carrington, Y. Qi, D. Watkins, 2007, Journal of Virology.

HLA-B*35-Px–mediated acceleration of HIV-1 infection by increased inhibitory immunoregulatory impulses

J. Goedert, M. Carrington, Xu G. Yu, 2009, The Journal of experimental medicine.

Rapid Inflammasome Activation following Mucosal SIV Infection of Rhesus Monkeys

J. Lifson, M. Piatak, R. Sékaly, 2016, Cell.

In Vivo Attenuation of Simian Immunodeficiency Virus by Disruption of a Tyrosine-Dependent Sorting Signal in the Envelope Glycoprotein Cytoplasmic Tail

M. Malim, J. Hoxie, D. Montefiori, 2001, Journal of Virology.

Variables affecting T-lymphocyte subsets in a volunteer blood donor population.

J. Lifson, E. Engleman, D. Sasaki, 1985, Clinical immunology and immunopathology.

Incomplete Protection against Simian Immunodeficiency Virus Vaginal Transmission in Rhesus Macaques by a Topical Antiviral Agent Revealed by Repeat Challenges

J. Lifson, W. Alvord, D. Lu, 2008, Journal of Virology.

Control of Heterologous Simian Immunodeficiency Virus SIVsmE660 Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques

N. Sardesai, D. Montefiori, Jishnu Das, 2018, Journal of Virology.

Mamu-B*08-Positive Macaques Control Simian Immunodeficiency Virus Replication

M. Carrington, Y. Qi, D. Watkins, 2007, Journal of Virology.

Antiretroviral Therapy prior to Acute Viral Replication Preserves CD4 T Cells in the Periphery but Not in Rectal Mucosa during Acute Simian Immunodeficiency Virus Infection

J. Lifson, M. Piatak, M. Roederer, 2008, Journal of Virology.

Increased Loss of CCR5+ CD45RA− CD4+ T Cells in CD8+ Lymphocyte-Depleted Simian Immunodeficiency Virus-Infected Rhesus Monkeys

D. Montefiori, Eun-Young Kim, Steven Wolinsky, 2008, Journal of Virology.

Simian Immunodeficiency Virus Infection in Neonatal Macaques

J. Lifson, M. Piatak, A. Lackner, 2003, Journal of Virology.

Antibody to the gp120 V1/V2 Loops and CD4+ and CD8+ T Cell Responses in Protection from SIVmac251 Vaginal Acquisition and Persistent Viremia

D. Lowy, D. Montefiori, J. Lifson, 2014, The Journal of Immunology.

Persistent Viremia Vaginal Acquisition andmac 251 from SIV T Cell Responses in Protection + and CD 8 + Antibody to the gp 120 V 1 / V 2 Loops and CD 4 Genoveffa

D. Lowy, J. Lifson, D. Venzon, 2014 .

Role of CD8+ Lymphocytes in Control of Simian Immunodeficiency Virus Infection and Resistance to Rechallenge after Transient Early Antiretroviral Treatment

B. M. Flynn, M. Nowak, D. Wodarz, 2001, Journal of Virology.

Highly Attenuated Vaccine Strains of Simian Immunodeficiency Virus Protect against Vaginal Challenge: Inverse Relationship of Degree of Protection with Level of Attenuation

D. Montefiori, R. Desrosiers, J. Lifson, 1999, Journal of Virology.

Cyanovirin-N Binds to gp120 To Interfere with CD4-Dependent Human Immunodeficiency Virus Type 1 Virion Binding, Fusion, and Infectivity but Does Not Affect the CD4 Binding Site on gp120 or Soluble CD4-Induced Conformational Changes in gp120

Q. Sattentau, M. Boyd, J. Lifson, 1999, Journal of Virology.

Partial Activation and Induction of Apoptosis in CD4+ and CD8+ T Lymphocytes by Conformationally Authentic Noninfectious Human Immunodeficiency Virus Type 1

J. Lifson, L. Arthur, J. Bess, 2001, Journal of Virology.

Human Immunodeficiency Virus Viremia Induces Plasmacytoid Dendritic Cell Activation In Vivo and Diminished Alpha Interferon Production In Vitro

R. Lempicki, Alison Johnson, C. Hallahan, 2008, Journal of Virology.

Human Immunodeﬁciency Virus Viremia Induces Plasmacytoid Dendritic Cell Activation In Vivo and Diminished Alpha Interferon Production In Vitro (cid:1)

R. Lempicki, Alison Johnson, C. Hallahan, 2008 .

Elevated Plasma Viral Loads in Romidepsin-Treated Simian Immunodeficiency Virus-Infected Rhesus Macaques on Suppressive Combination Antiretroviral Therapy

J. Lifson, W. Alvord, B. Keele, 2015, Antimicrobial Agents and Chemotherapy.

Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes

J. Lifson, D. Venzon, J. Bess, 2018, PLoS pathogens.

Recombinant human heterodimeric IL-15 complex displays extensive and reproducible N- and O-linked glycosylation

J. Lifson, N. Packer, E. Chertova, 2016, Glycoconjugate Journal.

IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates.

V. Maino, L. Picker, J. Lifson, 2006, The Journal of clinical investigation.

Three-Dimensional Imaging of HIV-1 Virological Synapses Reveals Membrane Architectures Involved in Virus Transmission

S. Subramaniam, G. Murphy, J. Lifson, 2014, Journal of Virology.

Preferential Small Intestine Homing and Persistence of CD8 T Cells in Rhesus Macaques Achieved by Molecularly Engineered Expression of CCR9 and Reduced Ex Vivo Manipulation

J. Lifson, B. Hill, J. D. Burke, 2019, Journal of Virology.

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

E. Boritz, J. Lifson, D. Douek, 2014, Nature.

Molecularly Tagged Simian Immunodeficiency Virus SIVmac239 Synthetic Swarm for Tracking Independent Infection Events

Octavio A. Quiñones, L. Picker, J. Lifson, 2014, Journal of Virology.

Damaged Intestinal Epithelial Integrity Linked to Microbial Translocation in Pathogenic Simian Immunodeficiency Virus Infections

S. Pittaluga, J. Lifson, A. Haase, 2010, PLoS pathogens.

Derivation of simian tropic HIV-1 infectious clone reveals virus adaptation to a new host

P. Bieniasz, J. Lifson, C. Fennessey, 2019, Proceedings of the National Academy of Sciences.

Nonhuman primate models for the evaluation of HIV-1 preventive vaccine strategies: model parameter considerations and consequences

J. Lifson, B. Keele, G. D. Del Prete, 2016, Current opinion in HIV and AIDS.

Evaluation of aldrithiol-2-inactivated preparations of HIV type 1 subtypes A, B, and D as reagents to monitor T cell responses.

J. Lifson, M. Robb, D. Birx, 2007, AIDS research and human retroviruses.

3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells

Bradley C. Lowekamp, K. Nagashima, S. Subramaniam, 2010, Proceedings of the National Academy of Sciences.

Reversion of CTL escape–variant immunodeficiency viruses in vivo

John Sidney, Alessandro Sette, Lara Vojnov, 2004, Nature Medicine.

A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challenge.

D. Watkins, J. Lifson, W. Koff, 2012, Vaccine.

Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis

L. Picker, J. Lifson, M. Piatak, 2009, The Journal of experimental medicine.

High Specific Infectivity of Plasma Virus from the Pre-Ramp-Up and Ramp-Up Stages of Acute Simian Immunodeficiency Virus Infection

Michael P. Busch, Mars Stone, David Montefiori, 2009, Journal of Virology.

High Speciﬁc Infectivity of Plasma Virus from the Pre-Ramp-Up and Ramp-Up Stages of Acute Simian Immunodeﬁciency Virus Infection (cid:1)

N. Haigwood, D. Montefiori, J. Lifson, 2009 .

Control of Viremia and Prevention of Simian-Human Immunodeficiency Virus-Induced Disease in Rhesus Macaques Immunized with Recombinant Vaccinia Viruses plus Inactivated Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 1 Particles

J. Lifson, L. Arthur, M. Piatak, 2003, Journal of Virology.

SIVmac pathogenesis in rhesus macaques of Chinese and Indian origin compared with primary HIV infections in humans

J. Lifson, B. Ling, R. Veazey, 2002, AIDS.

Simian immunodeficiency virus infection of monkeys as a model system for the study of AIDS pathogenesis, treatment, and prevention.

J. Lifson, V. Hirsch, 2000, Advances in pharmacology.

Viral Genetic Evolution in Macaques Infected with Molecularly Cloned Simian Immunodeficiency Virus Correlates with the Extent of Persistent Viremia

D. Montefiori, J. Lifson, Charles R. Brown, 1998, Journal of Virology.

Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys

H. Schuitemaker, U. Reimer, H. Wenschuh, 2015, Science.

Genetic Diversity of Simian Immunodeficiency Virus Encoding HIV-1 Reverse Transcriptase Persists in Macaques despite Antiretroviral Therapy

J. Lifson, J. Mellors, J. Coffin, 2010, Journal of Virology.

Effect of Humoral Immune Responses on Controlling Viremia during Primary Infection of Rhesus Monkeys with Simian Immunodeficiency Virus

D. Montefiori, R. Gelman, J. Lifson, 2003, Journal of Virology.

Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions.

J. Lifson, R. Gorelick, N. Bhardwaj, 2005, The Journal of clinical investigation.

Selection of unadapted, pathogenic SHIVs encoding newly transmitted HIV-1 envelope proteins.

D. Burton, D. Montefiori, P. Bieniasz, 2014, Cell host & microbe.

IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques

J. Lifson, N. Shenvi, G. Silvestri, 2021, Nature Communications.

Effects of Cytotoxic T Lymphocytes (CTL) Directed against a Single Simian Immunodeficiency Virus (SIV) Gag CTL Epitope on the Course of SIVmac239 Infection

Todd M. Allen, J. Berzofsky, A. Sette, 2002, Journal of Virology.

Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques

R. Desrosiers, J. Lifson, E. Rakasz, 2019, PLoS pathogens.

Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8+ T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection

Todd M. Allen, D. Watkins, J. Lifson, 2015, Journal of Virology.

Distribution, Persistence, and Efficacy of Adoptively Transferred Central and Effector Memory-Derived Autologous Simian Immunodeficiency Virus-Specific CD8+ T Cell Clones in Rhesus Macaques during Acute Infection

J. Lifson, M. Piatak, M. Roederer, 2009, The Journal of Immunology.

Inhibitory TCR Coreceptor PD-1 Is a Sensitive Indicator of Low-Level Replication of SIV and HIV-1

F. Pereyra, G. Freeman, D. Kaufmann, 2009, The Journal of Immunology.

Contribution of CD8+ T Cells to Containment of Viral Replication and Emergence of Mutations in Mamu-A*01-Restricted Epitopes in Simian Immunodeficiency Virus-Infected Rhesus Monkeys

Eun-Young Kim, Ronald S Veazey, Eun-Young Kim, 2008, Journal of Virology.

Immunization of Macaques with Single-Cycle Simian Immunodeficiency Virus (SIV) Stimulates Diverse Virus-Specific Immune Responses and Reduces Viral Loads after Challenge with SIVmac239

R. Desrosiers, K. Mansfield, J. Lifson, 2005, Journal of Virology.

Immunization of macaques with live simian human immunodeficiency virus (SHIV) vaccines conferred protection against AIDS induced by homologous and heterologous SHIVs and simian immunodeficiency virus.

J. Lifson, H. McClure, M. Piatak, 2002, Virology.

Emergence and Kinetics of Simian Immunodeficiency Virus-Specific CD8+ T Cells in the Intestines of Macaques during Primary Infection

K. Mansfield, J. Lifson, J. Altman, 2001, Journal of Virology.

Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen

David J. Harvey, Weston B. Struwe, Brandon F. Keele, 2018, Cell reports.

Tracking the Luminal Exposure and Lymphatic Drainage Pathways of Intravaginal and Intrarectal Inocula Used in Nonhuman Primate Models of HIV Transmission

P. Choyke, J. Lifson, Hisataka Kobayashi, 2014, PloS one.

Correction: CD8 T Cell Response Maturation Defined by Anentropic Specificity and Repertoire Depth Correlates with SIVΔnef-induced Protection

J. Lifson, R. Johnson, M. Piatak, 2015, PLoS Pathogens.

CD8 T Cell Response Maturation Defined by Anentropic Specificity and Repertoire Depth Correlates with SIVΔnef-induced Protection

J. Lifson, R. Johnson, M. Piatak, 2015, PLoS Pathogens.

Clonal expansion of SIV-infected cells in macaques on antiretroviral therapy is similar to that of HIV-infected cells in humans

S. Hughes, J. Lifson, J. Coffin, 2019, PLoS pathogens.

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection

Jerome H. Kim, J. Lifson, J. Ananworanich, 2018, Nature Medicine.

Envelope residue 375 substitutions in simian–human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques

G. Learn, H. Liao, J. Sodroski, 2016, Proceedings of the National Academy of Sciences.

Immunomodulatory effects of HSV-2 infection on immature macaque dendritic cells modify innate and adaptive responses.

A. Gettie, J. Blanchard, J. Lifson, 2005, Blood.

Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif

J. Hoxie, D. Montefiori, D. O’Connor, 2015, Journal of Virology.

Rare Control of SIVmac239 Infection in a Vaccinated Rhesus Macaque.

Todd M. Allen, D. Watkins, R. Desrosiers, 2017, AIDS Research and Human Retroviruses.

Vaccination with gag, vif, and nef Gene Fragments Affords Partial Control of Viral Replication after Mucosal Challenge with SIVmac239

D. Watkins, J. Lifson, M. Piatak, 2014, Journal of Virology.

CD8 Lymphocyte Depletion Enhances the Latency Reversal Activity of the SMAC Mimetic AZD5582 in ART-Suppressed Simian Immunodeficiency Virus-Infected Rhesus Macaques

A. Perelson, J. Lifson, N. Schoof, 2021, Journal of Virology.

Vaccine Protection against Simian Immunodeficiency Virus in Monkeys Using Recombinant Gamma-2 Herpesvirus

R. Desrosiers, K. Mansfield, J. Lifson, 2011, Journal of Virology.

D. O’Connor, J. Lifson, M. Piatak, 2009, Journal of Immunology.

Development of virus-specific immune responses in SHIV(KU)-infected macaques treated with PMPA.

J. Lifson, S. Buch, L. Foresman, 2001, Virology.

Evaluating the Intactness of Persistent Viral Genomes in Simian Immunodeficiency Virus-Infected Rhesus Macaques after Initiating Antiretroviral Therapy within One Year of Infection

J. Lifson, C. Fennessey, B. Keele, 2019, Journal of Virology.

Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection

R. Desrosiers, J. Lifson, A. Haase, 2016, PLoS pathogens.

Derivation and Characterization of Pathogenic Transmitted/Founder Molecular Clones from Simian Immunodeficiency Virus SIVsmE660 and SIVmac251 following Mucosal Infection

G. Learn, J. Lifson, G. Shaw, 2016, Journal of Virology.

RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy

Wei Shao, R. Stephens, J. Lifson, 2009, Retrovirology.

Vaccine-Induced Cellular Responses Control Simian Immunodeficiency Virus Replication after Heterologous Challenge

D. Watkins, J. Lifson, G. Shaw, 2009, Journal of Virology.

Comparative Characterization of Transfection- and Infection-Derived Simian Immunodeficiency Virus Challenge Stocks for In Vivo Nonhuman Primate Studies

Christopher J. Miller, David H. O'Connor, Brandon F. Keele, 2013, Journal of Virology.

Specific CD8+ T Cell Responses Correlate with Control of Simian Immunodeficiency Virus Replication in Mauritian Cynomolgus Macaques

Melisa L. Budde, D. O’Connor, J. Lifson, 2012, Journal of Virology.

MacaquesVirus Replication in Mauritian Cynomolgus with Control of Simian Immunodeficiency T Cell Responses Correlate + Specific CD8

Melisa L. Budde, D. O’Connor, J. Lifson, 2012 .

Novel Member of the CD209 (DC-SIGN) Gene Family in Primates

A. Hughes, J. Lifson, V. KewalRamani, 2003, Journal of Virology.

Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

D. Burton, D. Watkins, R. Desrosiers, 2021, Nature Communications.

Influence of Mismatch of Env Sequences on Vaccine Protection by Live Attenuated Simian Immunodeficiency Virus

R. Desrosiers, K. Mansfield, J. Lifson, 2013, Journal of Virology.

ADCC Develops Over Time during Persistent Infection with Live-Attenuated SIV and Is Associated with Complete Protection against SIVmac251 Challenge

A. Trkola, R. Desrosiers, K. Mansfield, 2012, PLoS pathogens.

New paradigms for HIV/AIDS vaccine development.

Louis J. Picker, L. Picker, J. Lifson, 2012, Annual review of medicine.

Potent Antibody-Mediated Neutralization and Evolution of Antigenic Escape Variants of Simian Immunodeficiency Virus Strain SIVmac239 In Vivo

R. Desrosiers, J. Lifson, E. Chang, 2008, Journal of Virology.

HIV-1 envelope pseudotyped viral vectors and infectious molecular clones expressing the same envelope glycoprotein have a similar neutralization phenotype, but culture in peripheral blood mononuclear cells is associated with decreased neutralization sensitivity.

J. Mascola, S. Zolla-Pazner, J. Lifson, 2005, Virology.

Longitudinal in vivo positron emission tomography imaging of infected and activated brain macrophages in a macaque model of human immunodeficiency virus encephalitis correlates with central and peripheral markers of encephalitis and areas of synaptic degeneration.

C. Mathis, B. Lopresti, J. Lifson, 2008, The American journal of pathology.

Optimization of the doxycycline-dependent simian immunodeficiency virus through in vitro evolution

A. Das, B. Berkhout, J. Lifson, 2008, Retrovirology.

Identification of Highly Attenuated Mutants of Simian Immunodeficiency Virus

R. Desrosiers, J. Lifson, R. Johnson, 1998, Journal of Virology.

Transient viral replication during analytical treatment interruptions in SIV infected macaques can alter the rebound-competent viral reservoir

J. Lifson, C. Fennessey, M. Davenport, 2021, PLoS pathogens.

Predictors of SIV recrudescence following antiretroviral treatment interruption

J. Lifson, C. Fennessey, M. Davenport, 2019, eLife.

Subnanometer structures of HIV-1 envelope trimers on aldrithiol-2-inactivated virus particles

Daniel S. Terry, J. Lifson, Baoshan Zhang, 2020, Nature Structural & Molecular Biology.

Generation and characterization of a SIVmac239 clone corrected at four suboptimal nucleotides

J. Lifson, C. Fennessey, B. Keele, 2015, Retrovirology.

Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo

W. Heneine, M. Peet, M. Lal, 2018, Nature Communications.

A Potent Combination Microbicide that Targets SHIV-RT, HSV-2 and HPV

A. Gettie, J. Blanchard, J. Lifson, 2014, PloS one.

Catching HIV 'in the act' with 3D electron microscopy.

S. Subramaniam, J. Lifson, L. Earl, 2013, Trends in microbiology.

An Intravaginal Ring That Releases the NNRTI MIV-150 Reduces SHIV Transmission in Macaques

A. Gettie, J. Blanchard, J. Lifson, 2012, Science Translational Medicine.

A MIV-150/Zinc Acetate Gel Inhibits SHIV-RT Infection in Macaque Vaginal Explants

A. Gettie, J. Blanchard, J. Lifson, 2014, PloS one.

A single dose of a MIV-150/Zinc acetate gel provides 24 h of protection against vaginal simian human immunodeficiency virus reverse transcriptase infection, with more limited protection rectally 8-24 h after gel use.

A. Gettie, J. Blanchard, J. Lifson, 2012, AIDS research and human retroviruses.

The Nonnucleoside Reverse Transcriptase Inhibitor MIV-150 in Carrageenan Gel Prevents Rectal Transmission of Simian/Human Immunodeficiency Virus Infection in Macaques

A. Gettie, J. Blanchard, J. Lifson, 2011, Journal of Virology.

An Antiretroviral/Zinc Combination Gel Provides 24 Hours of Complete Protection against Vaginal SHIV Infection in Macaques

A. Gettie, J. Blanchard, J. Lifson, 2011, PloS one.

A Macaque Model to Study Vaginal HSV-2/Immunodeficiency Virus Co-Infection and the Impact of HSV-2 on Microbicide Efficacy

A. Gettie, J. Blanchard, J. Lifson, 2009, PloS one.

Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study.

Rebecca Hoh, Wendy Hartogensis, Peter Bacchetti, 2015, The lancet. HIV.

Suppression of Viremia and Evolution of Human Immunodeficiency Virus Type 1 Drug Resistance in a Macaque Model for Antiretroviral Therapy

J. Lifson, J. Mellors, J. Coffin, 2007, Journal of Virology.

Role of CD4 in Normal Immunity and HIV Infection

J. Lifson, E. Engleman, 1989, Immunological reviews.

Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques

J. Lifson, D. Douek, J. Brenchley, 2010, Journal of Virology.

KIR3DL01 upregulation on gut natural killer cells in response to SIV infection of KIR- and MHC class I-defined rhesus macaques

Trent M. Prall, D. O’Connor, J. Lifson, 2017, PLoS pathogens.

Differential natural killer cell–mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes

William H. Carr, Todd J. Suscovich, Hendrik Streeck, 2007, The Journal of experimental medicine.

Generation of Simian-Tropic HIV-1 by Restriction Factor Evasion

P. Bieniasz, J. Lifson, M. Piatak, 2006, Science.

Optimization of intracellular cytokine staining for the quantitation of antigen-specific CD4+ T cell responses in rhesus macaques.

J. Lifson, R. Johnson, T. Yilma, 2004, Journal of immunological methods.

HIV vaccine design: insights from live attenuated SIV vaccines

Philip R. Johnson, D. Burton, D. Watkins, 2005, Nature Immunology.

Transduction with human telomerase reverse transcriptase immortalizes a rhesus macaque CD8+ T cell clone with maintenance of surface marker phenotype and function.

J. Lifson, H. Andersen, C. M. Trubey, 2007, AIDS research and human retroviruses.

Efficient inhibition of SIV replication in rhesus CD4+ T-cell clones by autologous immortalized SIV-specific CD8+ T-cell clones.

J. Lifson, M. Piatak, D. Ott, 2008, Virology.

Cytotoxic Capacity of SIV-Specific CD8+ T Cells against Primary Autologous Targets Correlates with Immune Control in SIV-Infected Rhesus Macaques

D. Watkins, C. Hallahan, S. Migueles, 2013, PLoS pathogens.

Peptides Derived from the CDR3‐Homologous Domain of the CD4 Molecule Are Specific Inhibitors of HIV‐1 and SIV Infection, Virus‐Induced Cell Fusion, and Postinfection Viral Transmission in Vitro

K. M. Hwang, J. Lifson, M. McGrath, 1990, Annals of the New York Academy of Sciences.

Gammaherpesvirus infection and malignant disease in rhesus macaques experimentally infected with SIV or SHIV

E. Jaffe, J. Lifson, M. Piatak, 2018, PLoS pathogens.

Induction of a virus-specific effector–memory CD4+ T cell response by attenuated SIV infection

R. Desrosiers, J. Lifson, R. Johnson, 2006, The Journal of experimental medicine.

The immunohistology of the persistent generalized lymphadenopathy syndrome (PGL).

R. Warnke, J. Lifson, E. Engleman, 1986, American journal of clinical pathology.

Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody

A. Perelson, J. Mascola, E. Boritz, 2020, Proceedings of the National Academy of Sciences.

Early antibody therapy can induce long-lasting immunity to SHIV

M. Nussenzweig, T. Chun, A. Fauci, 2017, Nature.

Human Immunodeficiency Virus Type 1 Monoclonal Antibodies Suppress Acute Simian-Human Immunodeficiency Virus Viremia and Limit Seeding of Cell-Associated Viral Reservoirs

J. Mascola, R. Koup, J. Lifson, 2015, Journal of Virology.

Considerations in the development of nonhuman primate models of combination antiretroviral therapy for studies of AIDS virus suppression, residual virus, and curative strategies

J. Lifson, G. D. Del Prete, 2013, Current opinion in HIV and AIDS.

Programed death-1/programed death-ligand 1 expression in lymph nodes of HIV infected patients: results of a pilot safety study in rhesus macaques using anti–programed death-ligand 1 (Avelumab)

S. Pittaluga, H. Lane, J. Lifson, 2016, AIDS.

Non-neutralizing Antibodies May Contribute to Suppression of SIVmac239 Viremia in Indian Rhesus Macaques

D. Watkins, J. Lifson, G. Alter, 2021, Frontiers in Immunology.

Rectal Acquisition of Simian Immunodeficiency Virus (SIV) SIVmac239 Infection despite Vaccine-Induced Immune Responses against the Entire SIV Proteome

P. Earl, B. Moss, D. Burton, 2020, Journal of Virology.

Vaccine-Elicited Mucosal and Systemic Antibody Responses Are Associated with Reduced Simian Immunodeficiency Viremia in Infant Rhesus Macaques

M. Hudgens, W. Jacobs, J. Lifson, 2016, Journal of Virology.

A Tonsillar PolyICLC/AT-2 SIV Therapeutic Vaccine Maintains Low Viremia Following Antiretroviral Therapy Cessation

A. Gettie, J. Lifson, M. Piatak, 2010, PloS one.

Immunization with Single-Cycle SIV Significantly Reduces Viral Loads After an Intravenous Challenge with SIVmac239

K. Mansfield, L. Picker, J. Lifson, 2009, PLoS pathogens.

Vaccine Protection by Live, Attenuated Simian Immunodeficiency Virus in the Absence of High-Titer Antibody Responses and High-Frequency Cellular Immune Responses Measurable in the Periphery

R. Desrosiers, K. Mansfield, J. Lifson, 2008, Journal of Virology.

Restricted Replication of Xenotropic Murine Leukemia Virus-Related Virus in Pigtailed Macaques

K. Nagashima, V. Pathak, J. Lifson, 2012, Journal of Virology.

Sex-Based Differences in Human Immunodeficiency Virus Type 1 Reservoir Activity and Residual Immune Activation

J. Karn, M. Altfeld, S. Lewin, 2018, The Journal of infectious diseases.

Protection by Live, Attenuated Simian Immunodeficiency Virus against Heterologous Challenge

D. Montefiori, R. Desrosiers, J. Lifson, 1999, Journal of Virology.

Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations

D. Montefiori, J. Lifson, R. Johnson, 1999, Nature Medicine.

Protection Afforded by an HIV Vaccine Candidate in Macaques Depends on the Dose of SIVmac251 at Challenge Exposure

D. Montefiori, J. Lifson, D. Venzon, 2013, Journal of Virology.

Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo

B. Liao, Corbin D. Jones, J. Lifson, 2020, Nature.

Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

J. Safrit, J. Lifson, D. Margolis, 2020, Nature.

Defining total-body AIDS-virus burden with implications for curative strategies

J. Lifson, A. Haase, D. Douek, 2017, Nature Medicine.

Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound

L. Picker, J. Lifson, Y. Fukazawa, 2018, Nature Medicine.

A B cell follicle sanctuary permits persistent productive SIV infection in elite controllers

L. Picker, J. Lifson, M. Piatak, 2014, Nature Medicine.

SIV persists in lymphoid tissues despite alemtuzumab-induced CD4+ T cell depletion

S. Lewin, L. Picker, J. Lifson, 2017 .

Supplemental Information CD 8 + Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy

J. Lifson, G. Silvestri, M. Paiardini, 2016 .

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques.

J. Lifson, J. Brenchley, M. Piatak, 2015, The Journal of clinical investigation.

Sex-Based Differences in HIV-1 Reservoir Activity and Residual Immune Activation.

J. Karn, M. Altfeld, S. Lewin, 2018 .

Antibody-mediated depletion of viral reservoirs is limited in SIV-infected macaques treated early with antiretroviral therapy.

J. Lifson, C. Fennessey, B. Keele, 2021, The Journal of clinical investigation.

Blocking α4β7 integrin binding to SIV does not improve virologic control

J. Lifson, K. Reimann, B. Keele, 2019, Science.

Evaluation of an antibody to α4β7 in the control of SIVmac239-nef-stop infection

M. Proschan, A. Fauci, H. Lane, 2019, Science.

The Landscape of Persistent Viral Genomes in ART-Treated SIV, SHIV, and HIV-2 Infections.

R. Siliciano, G. Gottlieb, J. Clements, 2019, Cell host & microbe.

TLR7 agonist administration to SIV-infected macaques receiving early initiated cART does not induce plasma viremia.

J. Lifson, W. Alvord, R. Kiser, 2019, JCI insight.

New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and Cure

B. Haynes, J. Lifson, G. Shaw, 2021, bioRxiv.

Effects of Treatment with Suppressive Combination Antiretroviral Drug Therapy and the Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid; (SAHA) on SIV-Infected Chinese Rhesus Macaques

D. Hazuda, J. Lifson, M. Piatak, 2014, PloS one.

Prevention of AIDS transmission through screening of the blood supply.

J. Lifson, E. Engleman, S. Galel, 1995, Annual review of immunology.

dendritic cells Immunodeficiency virus uptake, turnover, and two-phase transfer in human

J. Lifson, M. Piatak, A. Cunningham, 2013 .

Presentation of Exogenous Whole Inactivated Simian Immunodeficiency Virus by Mature Dendritic Cells Induces CD4+ and CD8+ T-Cell Responses

A. Gettie, J. Lifson, C. Santisteban, 2003, Journal of acquired immune deficiency syndromes.

Control of viremia and maintenance of intestinal CD4(+) memory T cells in SHIV(162P3) infected macaques after pathogenic SIV(MAC251) challenge.

D. Montefiori, J. Lifson, M. Piatak, 2009, Virology.

Polyinosinic-Polycytidylic Acid Is the Most Effective TLR Adjuvant for SIV Gag Protein–Induced T Cell Responses In Nonhuman Primates

L. Picker, J. Lifson, M. Piatak, 2013, The Journal of Immunology.

Utility of formaldehyde fixation for flow cytometry and inactivation of the AIDS associated retrovirus.

J. Lifson, E. Engleman, D. Sasaki, 1986, Journal of immunological methods.

DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge

N. Sardesai, J. Lifson, D. Venzon, 2013, Proceedings of the National Academy of Sciences.

Expression of a Broad Array of Negative Costimulatory Molecules and Blimp-1 in T Cells following Priming by HIV-1 Pulsed Dendritic Cells

J. Lifson, E. Shankar, M. Larsson, 2011, Molecular medicine.

Addendum: Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

L. Picker, J. Lifson, M. Piatak, 2011, Nature Network Boston.

Chemotherapy-induced eosinophilic pneumonia. Relation to bleomycin.

J. Lifson, T. Colby, S. Yousem, 1985, Chest.

Pol-Specific CD8+ T Cells Recognize Simian Immunodeficiency Virus-Infected Cells Prior to Nef-Mediated Major Histocompatibility Complex Class I Downregulation

D. Watkins, J. Lifson, T. Friedrich, 2007, Journal of Virology.

Production of Human Monoclonal Antibodies Using a Human-Mouse Fusion Partner

J. Lifson, E. Engleman, S. Foung, 1985 .

Protection against Simian Immunodeficiency Virus Vaginal Challenge by Using Sabin Poliovirus Vectors

R. Andino, J. Lifson, L. Fritts, 2001, Journal of Virology.

Corrigendum: Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge.

L. Picker, J. Lifson, M. Piatak, 2009, Nature Medicine.

Direct Relationship between Suppression of Virus-Specific Immunity and Emergence of Cytomegalovirus Disease in Simian AIDS

Fred Wang, Michael Mach, Amitinder Kaur, 2003, Journal of Virology.

CXCR5-Dependent Entry of CD8 T Cells into Rhesus Macaque B-Cell Follicles Achieved through T-Cell Engineering

J. Lifson, J. Estes, D. Ott, 2017, Journal of Virology.

Potential roles of follicular dendritic cell-associated osteopontin in lymphoid follicle pathology and repair and in B cell regulation in HIV-1 and SIV infection.

J. Carlis, J. Lifson, A. Haase, 2005, The Journal of infectious diseases.

Loss of tetherin antagonism by Nef impairs SIV replication during acute infection of rhesus macaques

J. Lifson, S. Capuano, David T. Evans, 2020, PLoS pathogens.

Anti-HIV B Cell Lines as Candidate Vaccine Biosensors

J. Mascola, J. Binley, R. Wyatt, 2012, The Journal of Immunology.

Viral Load Determination in Plasma and CSF From HTLV-I-Infected Patients. Real-Time Quantitation Using the Prism 7700.

J. Lifson, W. Miley, D. Waters, 1999 .

Complement Opsonization of HIV-1 Results in Decreased Antiviral and Inflammatory Responses in Immature Dendritic Cells via CR3

J. Lifson, A. Burgener, G. Westmacott, 2014, The Journal of Immunology.

Complement opsonization of HIV-1 results in a different intracellular processing pattern and enhanced MHC class I presentation by dendritic cells

J. Lifson, A. Burgener, G. Westmacott, 2013, European journal of immunology.

Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding

R. Desrosiers, J. Lifson, B. Keele, 2016, Scientific Reports.

In Vitro Priming Recapitulates In Vivo HIV-1 Specific T Cell Responses, Revealing Rapid Loss of Virus Reactive CD4+ T Cells in Acute HIV-1 Infection

E. Rosenberg, B. Walker, D. Kaufmann, 2009, PloS one.

Persistence of Viral Reservoirs in Multiple Tissues after Antiretroviral Therapy Suppression in a Macaque RT-SHIV Model

J. Lifson, J. Mellors, M. Piatak, 2013, PLoS ONE.

CR 3 Responses in Immature Dendritic Cells via in Decreased Antiviral and Inflammatory Complement Opsonization of HIV-1 Results

J. Lifson, A. Burgener, G. Westmacott, 2014 .

Potent Anti-Viral Activity of a Trispecific HIV Antibody in SHIV-Infected Monkeys

J. Mascola, R. Koup, J. Lifson, 2021, SSRN Electronic Journal.

New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention, and Cure

B. Haynes, J. Lifson, G. Shaw, 2021, Journal of Virology.

Oral clade C SHIV challenge models to study pediatric HIV-1 infection by breastmilk transmission

Alan D. Curtis, M. Hudgens, J. Lifson, 2019, bioRxiv.

Effect of Suberoylanilide Hydroxamic Acid (SAHA) Administration on the Residual Virus Pool in a Model of Combination Antiretroviral Therapy-Mediated Suppression in SIVmac239-Infected Indian Rhesus Macaques

Octavio A. Quiñones, D. Hazuda, J. Lifson, 2014, Antimicrobial Agents and Chemotherapy.

Effect of SAHA administration on the residual virus pool in a model of combination

Octavio A. Quiñones, D. Hazuda, J. Lifson, 2014 .

DNA and Protein Co-Immunization Improves the Magnitude and Longevity of Humoral Immune Responses in Macaques

N. Sardesai, D. Montefiori, J. Lifson, 2014, PloS one.

Immunogenicity and Protective Efficacy of Oligomeric Human Immunodeficiency Virus Type 1 gp140

P. Earl, C. Broder, B. Moss, 2001, Journal of Virology.

Progressive CD4+ central–memory T cell decline results in CD4+ effector–memory insufficiency and overt disease in chronic SIV infection

Z. Grossman, M. Meier-Schellersheim, V. Maino, 2007, The Journal of Experimental Medicine.

Importance of B-Cell Responses for Immunological Control of Variant Strains of Simian Immunodeficiency Virus

R. Desrosiers, J. Lifson, R. Johnson, 2003, Journal of Virology.

Evaluating a New Class of AKT/mTOR Activators for HIV Latency-Reversing Activity Ex Vivo and In Vivo

N. Krogan, W. Greene, Jeffrey R. Johnson, 2021, Journal of Virology.

Exposure to MIV-150 from a High-Dose Intravaginal Ring Results in Limited Emergence of Drug Resistance Mutations in SHIV-RT Infected Rhesus Macaques

A. Gettie, J. Blanchard, J. Lifson, 2014, PloS one.

Pathogenic Simian/Human Immunodeficiency Virus SHIVKUInoculated into Immunized Macaques Caused Infection, but Virus Burdens Progressively Declined with Time

J. Lifson, M. Piatak, O. Narayan, 2000, Journal of Virology.

Infection Leishmania and SIV-Infected Macaques from CpG Oligodeoxynucleotides Protect Normal

J. Lifson, Shuying Liu, M. Gursel, 2003 .

Antibody to human immunodeficiency virus correlates with decreased T helper lymphocytes in asymptomatic individuals

K. Steimer, J. Lifson, E. Engleman, 1987, Journal of medical virology.

Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS.

E. Masliah, J. Lifson, R. Schinazi, 2005, The Journal of clinical investigation.

Transient antibody to lymphadenopathy-associated virus/human T-lymphotropic virus type III and T-lymphocyte abnormalities in the wife of a man who developed the acquired immunodeficiency syndrome.

F. Brun-Vézinet, J. Lifson, J. Chermann, 1985, Annals of internal medicine.

Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication

J. Billingsley, J. Lifson, D. Douek, 2018, PLoS pathogens.

CpG‐C ISS‐ODN activation of blood‐derived B cells from healthy and chronic immunodeficiency virus‐infected macaques

A. Gettie, J. Lifson, I. Sivin, 2006, Journal of leukocyte biology.

Electron Tomography of the Contact between T Cells and SIV/HIV-1: Implications for Viral Entry

Sriram Subramaniam, Adam E Bennett, Alberto Bartesaghi, 2007, PLoS pathogens.

Elimination of Retroviral Infectivity by N-Ethylmaleimide with Preservation of Functional Envelope Glycoproteins

David E. Ott, David R. Morcock, Robert J. Gorelick, 2005, Journal of Virology.

Antibodies with High Avidity to the gp120 Envelope Protein in Protection from Simian Immunodeficiency Virus SIVmac251 Acquisition in an Immunization Regimen That Mimics the RV-144 Thai Trial

Jerome H. Kim, D. Montefiori, D. Stablein, 2012, Journal of Virology.

Local and Systemic Effects of Intranodally

A. Gettie, J. Lifson, I. Sivin, 2006 .

Programming cytomegalovirus as an HIV vaccine.

L. Picker, J. Lifson, K. Früh, 2023, Trends in immunology.

Progressive CD4+ central–memory T cell decline results in CD4+ effector–memory insufficiency and overt disease in chronic SIV infection

Z. Grossman, M. Meier-Schellersheim, V. Maino, 2007, The Journal of experimental medicine.

Transient early post‐inoculation anti‐retroviral treatment facilitates controlled infection with sparing of CD4+ T cells in gut‐associated lymphoid tissues in SIVmac239‐infected rhesus macaques, but not resistance to rechallenge

J. Blanchard, J. Lifson, M. Piatak, 2003, Journal of medical primatology.

Recombinant Herpesvirus Vectors: Durable Immune Responses and Durable Protection against Simian Immunodeficiency Virus SIVmac239 Acquisition

D. Watkins, R. Desrosiers, J. Lifson, 2021, Journal of virology.

Sustained IL-15 response signature predicts RhCMV/SIV vaccine efficacy

Leanne S. Whitmore, Xinxia Peng, J. Komorowski, 2021, bioRxiv.

HIV: Seeking ultimate victory

L. Picker, J. Lifson, 2015, Nature.

Early Sites of Virus Replication After Oral SIVmac251 Infection of Infant Macaques: Implications for Pathogenesis.

J. Lifson, M. Piatak, Bonnie L. Phillips, 2017, AIDS research and human retroviruses.

Corrigendum: Immune clearance of highly pathogenic SIV infection

Matthew S. Lewis, L. Picker, J. Lifson, 2014, Nature.

Increased IL-15 Production Is Associated with Higher Susceptibility of Memory CD4 T Cells to Simian Immunodeficiency Virus during Acute Infection12

J. Lifson, M. Piatak, M. Roederer, 2009, The Journal of Immunology.

Sequential immunization of macaques with two differentially attenuated vaccines induced long-term virus-specific immune responses and conferred protection against AIDS caused by heterologous simian human immunodeficiency Virus (SHIV(89.6)P).

J. Lifson, H. McClure, M. Piatak, 2001, Virology.

Tonsillar Application of AT-2 SIV Affords Partial Protection Against Rectal Challenge With SIVmac239

A. Gettie, J. Lifson, M. Piatak, 2009, Journal of acquired immune deficiency syndromes.

In Vivo Validation of the Viral Barcoding of Simian Immunodeficiency Virus SIVmac239 and the Development of New Barcoded SIV and Subtype B and C Simian-Human Immunodeficiency Viruses

L. Picker, J. Lifson, C. Fennessey, 2019, Journal of Virology.

Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy

J. Lifson, C. Fennessey, M. Davenport, 2017, PLoS pathogens.

Characterization of Peripheral and Mucosal Immune Responses In Rhesus Macaques on Long-Term Tenofovir and Emtricitabine Combination Antiretroviral Therapy

A. Gettie, J. Lifson, M. Piatak, 2012, Journal of acquired immune deficiency syndromes.

Longitudinal follow up of SIVmac pathogenesis in rhesus macaques of Chinese origin: emergence of B cell lymphoma

J. Lifson, B. Ling, R. Veazey, 2002, Journal of medical primatology.

Macrophages relate presynaptic and postsynaptic damage in simian immunodeficiency virus encephalitis.

J. Lifson, C. Wiley, T. Reinhart, 2002, The American journal of pathology.

Envelope-Modified Single-Cycle Simian Immunodeficiency Virus Selectively Enhances Antibody Responses and Partially Protects against Repeated, Low-Dose Vaginal Challenge

K. Mansfield, J. Lifson, M. Piatak, 2010, Journal of Virology.

Lymphoid tissues contribute to viral clonotypes present in plasma at early post-ATI in SIV-infected rhesus macaques

J. Lifson, C. Fennessey, B. Keele, 2023, bioRxiv.

CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption

J. Lifson, D. Margolis, K. Bar, 2020, Nature Medicine.

Prevalence and risk of residual viremia after ART in low- and middle-income countries

J. Lifson, K. Ruxrungtham, S. Kerr, 2021, Medicine.

A single vaccination with attenuated SIVmac 239 via the tonsillar route confers partial protection against challenge with SIVmac 251 at a distant mucosal site, the rectum.

R. Steinman, J. Lifson, P. Rácz, 2007, Frontiers in bioscience : a journal and virtual library.

Temporal/compartmental changes in viral RNA and neuronal injury in a primate model of NeuroAIDS

M. Vangel, E. Halpern, E. Masliah, 2018, PloS one.

Non-cytolytic CD8 T-cell anti-HIV responses in primary HIV-1 infection

J. Lifson, J. Levy, L. Yang, 1994, The Lancet.

A combination microbicide gel protects macaques against vaginal simian human immunodeficiency virus-reverse transcriptase infection, but only partially reduces herpes simplex virus-2 infection after a single high-dose cochallenge.

A. Gettie, J. Blanchard, J. Lifson, 2014, AIDS research and human retroviruses.

Oral Immunization of Macaques with Attenuated Vaccine Virus Induces Protection against Vaginally Transmitted AIDS

J. Lifson, H. McClure, L. Foresman, 1998, Journal of Virology.

Distinct Phenotype, Longitudinal Changes of Numbers and Cell-Associated Virus in Blood Dendritic Cells in SIV-Infected CD8-Lymphocyte Depleted Macaques

J. Lifson, M. Piatak, K. Williams, 2015, PLoS ONE.

Vaccine Protection against Simian Immunodeficiency Virus by Recombinant Strains of Herpes Simplex Virus

David M. Knipe, Amitinder Kaur, R. Means, 2000, Journal of Virology.

Low-level alternative tRNA priming of reverse transcription of HIV-1 and SIV in vivo

J. Lifson, C. Fennessey, B. Keele, 2019, Retrovirology.

Lasting effects of transient postinoculation tenofovir [9-R-(2-Phosphonomethoxypropyl)adenine] treatment on SHIV(KU2) infection of rhesus macaques.

D. Wodarz, J. Lifson, S. Buch, 2000, Virology.

Use of a Small Molecule CCR5 Inhibitor in Macaques to Treat Simian Immunodeficiency Virus Infection or Prevent Simian–Human Immunodeficiency Virus Infection

R. Doms, John P. Moore, Steven Wolinsky, 2003, The Journal of experimental medicine.

Glycosylation of gp41 of Simian Immunodeficiency Virus Shields Epitopes That Can Be Targets for Neutralizing Antibodies

R. Desrosiers, J. Lifson, Shuji Sato, 2008, Journal of Virology.

Glycosylation of gp41 of Simian Immunodeﬁciency Virus Shields Epitopes That Can Be Targets for Neutralizing Antibodies (cid:1)

R. Desrosiers, J. Lifson, Shuji Sato, 2008 .

Short Communication: Ultrasensitive Immunoassay for Assessing Residual Simian-Tropic HIV in Nonhuman Primate Models of AIDS.

P. Bieniasz, J. Lifson, R. Gorelick, 2019, AIDS research and human retroviruses.

Complement Opsonization of HIV-1 Enhances the Uptake by Dendritic Cells and Involves the Endocytic Lectin and Integrin Receptor Families

J. Lifson, Rada Ellegård, M. Larsson, 2011, PloS one.

Author Correction: Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

Cynthia A. Derdeyn, Deanna A. Kulpa, Guido Silvestri, 2020, Nature.

Ultrasensitive Immunoassay for Simian Immunodeficiency Virus p27CA.

J. Lifson, B. Keele, R. Gorelick, 2018, AIDS research and human retroviruses.

Comparison of Plasma Viremia and Antibody Responses in Macaques Inoculated with Envelope Variants of Single-Cycle Simian Immunodeficiency Virus Differing in Infectivity and Cellular Tropism

J. Lifson, D. Douek, J. Brenchley, 2007, Journal of Virology.

Correction: Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes

J. Lifson, D. Venzon, J. Bess, 2018, PLoS Pathogens.

In Vivo Binding and Retention of CD4-Specific DARPin 57.2 in Macaques

A. Trkola, A. Gettie, J. Blanchard, 2010, PloS one.

Generation and characterization of a SIVmac239 clone corrected at four suboptimal nucleotides

J. Lifson, C. Fennessey, B. Keele, 2015, Retrovirology.

Weekly pulse methotrexate in rheumatoid arthritis. Clinical and immunologic effects in a randomized, double-blind study.

J. Lifson, J. Chermann, S. West, 1985, Annals of internal medicine.

Mucosal challenge of Macaca nemestrina with simian immunodeficiency virus (SIV) following SIV nucleocapsid mutant DNA vaccination *

B. M. Flynn, J. Lifson, L. Arthur, 2000, Journal of medical primatology.

SIV clearance from neonatal macaques following transient CCR5 depletion

J. Lifson, K. Reimann, S. Deeks, 2023, bioRxiv.

Blocking of integrins inhibits HIV-1 infection of human cervical mucosa immune cells with free and complement-opsonized virions.

J. Lifson, Rada Ellegård, M. Larsson, 2013, European journal of immunology.

α4+β7hiCD4+ memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection

J. Lifson, M. Piatak, M. Roederer, 2009, Mucosal Immunology.

Antiretroviral Therapy in Simian Immunodeficiency Virus-Infected Sooty Mangabeys: Implications for AIDS Pathogenesis

J. Lifson, B. Keele, D. Carnathan, 2016, Journal of Virology.

IL-21 and IFN alpha therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques

J. Lifson, N. Shenvi, G. Silvestri, 2022 .

Virologic and immunologic correlates of viral control after ART-interruption in SIV-infected rhesus macaques

J. Lifson, R. Sékaly, M. Paiardini, 2015 .

Increased CD4+ T Cell Levels during IL-7 Administration of Antiretroviral Therapy-Treated Simian Immunodeficiency Virus-Positive Macaques Are Not Dependent on Strong Proliferative Responses

L. Picker, J. Lifson, B. Assouline, 2010, The Journal of Immunology.

Long-acting lenacapavir protects macaques against intravenous challenge with simian-tropic HIV

P. Bieniasz, J. Lifson, R. Gorelick, 2023, EBioMedicine.

Ultrasensitive Immunoassay for Simian Immunodeficiency Virus p27CA.

J. Lifson, B. Keele, R. Gorelick, 2018, AIDS research and human retroviruses.

Considerations in the development of nonhuman primate models of combination antiretroviral therapy for studies of AIDS virus suppression, residual virus, and curative strategies

J. Lifson, G. D. Del Prete, 2013, Current opinion in HIV and AIDS.

RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy

R. Stephens, J. Lifson, J. Mellors, 2009, Retrovirology.

Antiretroviral Therapy prior to Acute Viral Replication Preserves CD4 T Cells in the Periphery but Not in Rectal Mucosa during Acute Simian Immunodeficiency Virus Infection

J. Lifson, M. Piatak, M. Roederer, 2008, Journal of Virology.

Sites, mechanism of action and lack of reversibility of primate lentivirus inactivation by preferential covalent modification of virion internal proteins.

J. Lifson, J. Bess, E. Chertova, 2003, Current molecular medicine.

M. Hudgens, W. Jacobs, J. Lifson, 2016, Clinical and Vaccine Immunology.

CCR7+ CD4 T Cell Immunosurveillance Disrupted in Chronic SIV-Induced Neuroinflammation in Rhesus Brain

J. Lifson, A. Dinasarapu, B. Durbin-Johnson, 2023, bioRxiv.

Recombinant human heterodimeric IL-15 complex displays extensive and reproducible N- and O-linked glycosylation

J. Lifson, N. Packer, E. Chertova, 2015, Glycoconjugate Journal.

Methode de determination quantitative du vih

J. Lifson, M. Piatak, K. Luk, 1994 .

Truncating the gp41 Cytoplasmic Tail of Simian Immunodeficiency Virus Decreases Sensitivity to Neutralizing Antibodies without Increasing the Envelope Content of Virions

J. Lifson, J. Bess, E. White, 2017, Journal of Virology.

Vaccine Protection against Simian Immunodeficiency Virus in Monkeys Using Recombinant Gamma-2 Herpesvirus

R. Desrosiers, K. Mansfield, J. Lifson, 2011, Journal of Virology.

Rare Control of SIVmac239 Infection in a Vaccinated Rhesus Macaque.

Todd M. Allen, D. Watkins, R. Desrosiers, 2017, AIDS research and human retroviruses.

Vaccine Protection by Live, Attenuated Simian Immunodeficiency Virus in the Absence of High-Titer Antibody Responses and High-Frequency Cellular Immune Responses Measurable in the Periphery

R. Desrosiers, K. Mansfield, J. Lifson, 2008, Journal of Virology.

Strains of Herpes Simplex Virus Immunodeficiency Virus by Recombinant Vaccine Protection against Simian

R. Means, J. Lifson, D. Knipe, 2000 .

Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques.

C. Deming, D. Hazuda, M. Lederman, 2013, The Journal of clinical investigation.

Acute hemorrhagic obstructive uropathy as a complication of experimental autoimmune encephalomyelitis.

J. Lifson, R. M. Williams, F. Carone, 1983, Archives of pathology & laboratory medicine.

Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8+ T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection

Todd M. Allen, D. Watkins, J. Lifson, 2015, Journal of Virology.

Increased Loss of CCR5+ CD45RA− CD4+ T Cells in CD8+ Lymphocyte-Depleted Simian Immunodeficiency Virus-Infected Rhesus Monkeys

D. Montefiori, Eun-Young Kim, Steven Wolinsky, 2008, Journal of Virology.

On Strong Proliferative Responses Virus-positive Macaques Are Not Dependent Therapy-treated Simian Immunodeficiency Administration of Antiretroviral T Cell Levels during Il-7 + Increased Cd4

L. Picker, J. Lifson, B. Assouline, 2022 .

Early antibody therapy can induce long-lasting immunity to SHIV

M. Nussenzweig, T. Chun, A. Fauci, 2017, Nature.

Correction: CD8 T Cell Response Maturation Defined by Anentropic Specificity and Repertoire Depth Correlates with SIVΔnef-induced Protection

J. Lifson, M. Piatak, J. Gillis, 2015, PLoS pathogens.

AZD5582 plus SIV-specific antibodies reduce lymph node viral reservoirs in antiretroviral therapy-suppressed macaques

A. Perelson, J. Safrit, J. Lifson, 2023, Nature Medicine.

Mechanisms underlying (cid:1)(cid:2) T-cell subset perturbations in SIV-infected Asian rhesus macaques

J. Lifson, J. Brenchley, K. Ladell, 2010 .

Cerebrovascular reactivity to CO2: Modulation by arterial pressure

J. Lifson, E. Rubinstein, O. Scremin, 1985, Experientia.

Loss of CD103+ DCs and Mucosal IL-17+ and IL-22+ Lymphocytes is Associated with Mucosal Damage in SIV Infection

Y. Belkaid, J. Lifson, J. Brenchley, 2012, Mucosal Immunology.

HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes

H. Tagare, J. Lifson, P. Uchil, 2023, Nature.

Differential natural killer cell–mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes

Todd M. Allen, M. Altfeld, M. Carrington, 2007, The Journal of experimental medicine.

Expression of a Broad Array of Negative Costimulatory Molecules and Blimp-1 in T Cells following Priming by HIV-1 Pulsed Dendritic Cells

J. Lifson, E. Shankar, M. Larsson, 2011, Molecular medicine.

Highly Efficient Autologous HIV-1 Isolation by Coculturing Macrophage With Enriched CD4+ T Cells From HIV-1 Patients

J. Gatell, J. Lifson, J. Alcamí, 2022, Frontiers in Virology.

Expression of PD‐L1 and PD‐L2 on human macrophages is up‐regulated by HIV‐1 and differentially modulated by IL‐10

B. Walker, D. Kaufmann, J. Lifson, 2011, Journal of leukocyte biology.

Immunization with Single-Cycle SIV Significantly Reduces Viral Loads After an Intravenous Challenge with SIVmac239

K. Mansfield, L. Picker, J. Lifson, 2009, PLoS pathogens.

Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy

J. Lifson, C. Fennessey, S. Capuano, 2024, bioRxiv.

Potent antibody-dependent cellular cytotoxicity of a V2-specific antibody is not sufficient for protection of macaques against SIV challenge

J. Lifson, C. Fennessey, T. Friedrich, 2024, PLoS pathogens.

No evidence for ongoing replication on ART in SIV-infected macaques

J. Lifson, C. Fennessey, G. D. Del Prete, 2024, Nature communications.

Vaccine protection against simian immunodeficiency virus in monkeys using recombinant gamma-2 herpesvirus

J. Lifson, J. Bilello, R., 2014 .

Addendum: Immune clearance of highly pathogenic SIV infection

Matthew S. Lewis, L. Picker, J. Lifson, 2017, Nature.

Administration of anti-HIV-1 broadly neutralizing monoclonal antibodies with increased affinity to Fcγ receptors during acute SHIVAD8-EO infection

J. Mascola, E. Boritz, R. Koup, 2024, Nature communications.