C. Spina

发表

Dynamics of T Cell Responses in HIV Infection1

D. Richman, S. Rowland-Jones, S. Little, 2002, The Journal of Immunology.

Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: Intrinsic stability predicts lifelong persistence

D. Richman, L. Bacheler, H. Günthard, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Preferential replication of HIV-1 in the CD45RO memory cell subset of primary CD4 lymphocytes in vitro.

D. Richman, C. Spina, H. Prince, 1997, The Journal of clinical investigation.

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

D. Richman, P. Klenerman, S. Rowland-Jones, 2002, Nature Medicine.

HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function

Douglas D. Richman, Tao Dong, Victor Appay, 2000, The Journal of experimental medicine.

Evolution of Envelope Sequences of Human Immunodeficiency Virus Type 1 in Cellular Reservoirs in the Setting of Potent Antiviral Therapy

Alan S. Perelson, Douglas D. Richman, Simon D. W. Frost, 1999, Journal of Virology.

Effect of influenza vaccination on viral replication and immune response in persons infected with human immunodeficiency virus receiving potent antiretroviral therapy.

R. Haubrich, D. Richman, H. Günthard, 2000, The Journal of infectious diseases.

CD44 microbeads accelerate HIV-1 infection in T cells.

C. Spina, I. Johnston, V. Terry, 2009, Virology.

Pharmacologic Inhibition of Nedd8 Activation Enzyme Exposes CD4-Induced Epitopes within Env on Cells Expressing HIV-1

Mary K. Lewinski, C. Spina, M. Lewinski, 2015, Journal of Virology.

Inhibition of HIV replication by pokeweed antiviral protein targeted to CD4+ cells by monoclonal antibodies

D. Richman, C. Spina, J. Ledbetter, 1990, Nature.

Subclinical Cytomegalovirus DNA Is Associated with CD4 T Cell Activation and Impaired CD8 T Cell CD107a Expression in People Living with HIV despite Early Antiretroviral Therapy

C. Spina, S. Gianella, M. Massanella, 2019, Journal of Virology.

Mixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency.

D. Richman, C. Spina, D. Margolis, 2015, Antiviral research.

HIV viral kinetics and T cell dynamics in antiretroviral naïve persons starting an integrase strand transfer inhibitor and protease inhibitor regimen

R. Haubrich, C. Spina, E. Daar, 2017, HIV clinical trials.

Sulfonation pathway inhibitors block reactivation of latent HIV-1.

John A. Young, C. Spina, P. Ahlquist, 2014, Virology.

Intraperitoneal immunotherapy of epithelial ovarian carcinoma with Corynebacterium parvum.

R. Berkowitz, C. Griffiths, L. Parker, 1985, American journal of obstetrics and gynecology.

Macaque Multimeric Soluble CD40 Ligand and GITR Ligand Constructs Are Immunostimulatory Molecules In Vitro

J. Lifson, C. Spina, R. Kornbluth, 2006, Clinical and Vaccine Immunology.

Microwell devices with finger-like channels for long-term imaging of HIV-1 expression kinetics in primary human lymphocytes.

L. Weinberger, C. Spina, A. Groisman, 2012, Lab on a chip.

Dynamics of T Cell Responses in HIV Infection

D. Richman, S. Rowland-Jones, S. Little, 2002, The Journal of Immunology.

Transcriptional Modulation of Human Endogenous Retroviruses in Primary CD4+ T Cells Following Vorinostat Treatment

D. Richman, C. Spina, G. Magiorkinis, 2018, Front. Immunol..

Micro RNA targets in HIV latency - insights into novel layers of latency control.

Ashley I Heinson, C. Spina, B. MacArthur, 2020, AIDS research and human retroviruses.

Intraperitoneal recombinant alpha-interferon for "salvage" immunotherapy in stage III epithelial ovarian cancer: a Gynecologic Oncology Group Study.

N. Hacker, C. Spina, L. Lagasse, 1985, Cancer research.

Interferon Production by Human Cells In Vitro

C. Spina, H. D. Golden, R. Chang, 1972 .

Interferon Production by Human Cells

C. Spina, H. D. Golden, L. Mishra, 2022 .

Cytotoxic studies in human newborns: lessened allogeneic cell-induced (augmented) cytotoxicity but strong lymphokine-activated cytotoxicity of cord mononuclear cells.

C. Spina, E. R. Stiehm, T. Chin, 1986, Cellular immunology.

Alterations in cytotoxic and phenotypic subsets of natural killer cells in acquired immune deficiency syndrome (AIDS)

G. Beall, C. Spina, M. Gottlieb, 2004, Journal of Clinical Immunology.

Altered cellular immune functions in patients with Down's syndrome.

E. Korn, C. Spina, J. Fahey, 1981, American journal of diseases of children.

Brief Report: Effect of CMV and HIV Transcription on CD57 and PD-1 T-Cell Expression During Suppressive ART

C. Spina, E. Daar, S. Gianella, 2016, Journal of acquired immune deficiency syndromes.

Herpes viruses and HIV-1 drug resistance mutations influence the virologic and immunologic milieu of the male genital tract

D. Richman, S. Little, C. Spina, 2013, AIDS.

Associations between Virologic and Immunologic Dynamics in Blood and in the Male Genital Tract

D. Richman, S. Little, C. Spina, 2011, Journal of Virology.

Histone deacetylase inhibitors induce complex host responses that contribute to differential potencies of these compounds in HIV reactivation

D. Richman, C. Spina, N. Beliakova-Bethell, 2019, The Journal of Biological Chemistry.

Human spontaneous killer cells selective for tumour-derived target cells

S. Targan, C. Spina, M. Jondal, 1978, Nature.

Azathioprine as an Immune Modulating Drug: Clinical Applications

C. Spina, 1984, Clinics in Immunology and Allergy.

Dose-responsive gene expression in suberoylanilide hydroxamic acid-treated resting CD4+ T cells

C. Spina, D. Margolis, A. Singhania, 2015, AIDS.

Viral Dynamics of Acute HIV-1 Infection

Douglas D. Richman, Angela R. McLean, Celsa A. Spina, 1999, The Journal of experimental medicine.

Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection

Tao Dong, Nathalie Rufer, Susan Little, 2004, PLoS biology.

Pathogenic and protective correlates of T cell proliferation in AIDS. HNRC Group. HIV Neurobehavioral Research Center.

I. Grant, C. Spina, J. McCutchan, 1996, The Journal of clinical investigation.

Interferon Production byHumanCells InVitro

C. Spina, R. Chang, L. Mishra, 1972 .

Dynamics of total, linear nonintegrated, and integrated HIV-1 DNA in vivo and in vitro.

R. Haubrich, R. Shafer, D. Richman, 2008, The Journal of infectious diseases.

Maraviroc intensification in patients with suppressed HIV viremia has limited effects on CD4+ T cell recovery and gene expression.

R. Haubrich, C. Spina, M. Witt, 2014, Antiviral research.

Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein

D. Richman, C. Spina, M. Pandori, 1996, Journal of Virology.

Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene

D. Richman, C. Spina, J. Guatelli, 1994, Journal of virology.

The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes

D. Richman, C. Spina, J. Guatelli, 1994, The Journal of experimental medicine.

Suppression of natural killer cell cytotoxicity in the peripheral blood of patients receiving interferon therapy.

C. Spina, J. Fahey, F. Dorey, 1983, Journal of biological response modifiers.

Cytomegalovirus Replication in Semen Is Associated with Higher Levels of Proviral HIV DNA and CD4+ T Cell Activation during Antiretroviral Treatment

R. Haubrich, D. Richman, S. Little, 2014, Journal of Virology.

Highly Precise Measurement of HIV DNA by Droplet Digital PCR

Douglas D. Richman, Celsa A. Spina, Steven M. Lada, 2013, PloS one.

Gut Lactobacillales are associated with higher CD4 and less microbial translocation during HIV infection

D. Richman, S. Little, C. Spina, 2013, AIDS.

Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro

D. Richman, C. Spina, J. Guatelli, 1995, Journal of virology.

Recovery of replication-competent HIV despite prolonged suppression of plasma viremia.

D. Richman, H. Günthard, D. Havlir, 1997, Science.

The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation.

D. Richman, C. Spina, M. Pandori, 1995, Virology.

Depression of the generation of cell-mediated cytotoxicity by macrophage-like suppressor cells in bladder carcinoma patients.

C. Spina, S. Brosman, J. Fahey, 1981, Cancer research.

Soluble suppressor factor produced by pokeweek mitogen-stimulated human peripheral blood leukocytes.

C. Spina, J. Fahey, F. Hofman, 1980, Cellular immunology.

An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients

Eric Verdin, Celsa A. Spina, Alberto Bosque, 2013, PLoS pathogens.

Phenotypic and cytotoxic characteristics of the immune cells of the human placenta.

C. Spina, E. Stiehm, A. Goldsobel, 1986, Cellular immunology.

HIV-specific Cytotoxic T Cells from Long-Term Survivors Select a Unique T Cell Receptor

Douglas D. Richman, Tao Dong, Susan Little, 2004, The Journal of experimental medicine.

Predictors of virologic response in persons who start antiretroviral therapy during recent HIV infection

D. Richman, F. Vaida, S. Little, 2014, AIDS.

Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1.

Matthew C Strain, Diane V Havlir, D. Richman, 2005, The Journal of infectious diseases.

Long non-coding RNAs and latent HIV – A search for novel targets for latency reversal

C. Spina, N. Beliakova-Bethell, C. White, 2019, PloS one.

Prevalence and T-cell phenotype of slow HIV disease progressors with robust HIV replication.

C. Spina, Davey M. Smith, S. May, 2009, Journal of acquired immune deficiency syndromes.

Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model

D. Richman, C. Spina, D. Margolis, 2016, PLoS pathogens.

Cerebrospinal Fluid (CSF) CD8+ T-Cells That Express Interferon-Gamma Contribute to HIV Associated Neurocognitive Disorders (HAND)

C. Spina, R. Ellis, S. Letendre, 2015, PloS one.

HIV-1 latency is established preferentially in minimally activated and non-dividing cells during productive infection of primary CD4 T cells

Mary K. Lewinski, C. Spina, M. Lewinski, 2015, PloS one.

Depletion of latent HIV-1 infection in vivo: a proof-of-concept study

Cheryl Jennings, Ian B Hogue, Sarah Palmer, 2005, The Lancet.

Integrated proteomics and transcriptomics analyses identify novel cell surface markers of HIV latency.

D. Richman, C. Spina, N. Beliakova-Bethell, 2022, Virology.

Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

C. Spina, J. Mellors, Helen Yu, 2014, PLoS pathogens.

Multimeric Soluble CD40 Ligand and GITR Ligand as Adjuvants for Human Immunodeficiency Virus DNA Vaccines

C. Spina, R. Kornbluth, Xiao-Fang Yu, 2006, Journal of Virology.

Suberoylanilide hydroxamic acid induces limited changes in the transcriptome of primary CD4+ T cells

D. Richman, C. Spina, A. Singhania, 2013, AIDS.

The effect of cell subset isolation method on gene expression in leukocytes

C. Spina, M. Massanella, N. Beliakova-Bethell, 2014, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Intraperitoneal administration of human recombinant interferon-alpha in patients with ovarian cancer: effects on lymphocyte phenotype and cytotoxicity.

C. Spina, J. Berek, A. Lichtenstein, 1988, Cancer research.

Intraperitoneal Recombinant α-Interferon for “Salvage” Immunotherapy in Stage III Epithelial Ovarian Cancer: A Gynecologic Oncology Group Study

N. Hacker, C. Spina, L. Lagasse, 1985 .

Suppression of spontaneous in vitro transformation of autologous leukocytes by plasma from convalescent and postconvalescent infectious mononucleosis patients.

C. Spina, R. Chang, 1975, Journal of the National Cancer Institute.

Flow cytometric screening for anti-leishmanials in a human macrophage cell line.

R. Schooley, C. Spina, K. Chang, 2010, Experimental parasitology.

Cell surface CD4 downregulation and resistance to superinfection induced by a defective provirus of HIV-1.

D. Richman, S. Little, C. Spina, 1994, Virology.

Increased Toll-Like Receptor Signaling Pathways Characterize CD8+ Cells in Rapidly Progressive SIV Infection

C. Spina, H. Fox, Eduardo Bustamante, 2012, BioMed research international.

In vitro stimulation of lymphocytes of donors seronegative for Epstein-Barr virus by preparations of inactivated Epstein-Barr virus.

C. Spina, R. Chang, 1976, The Journal of infectious diseases.

Relative efficacy of T cell stimuli as inducers of productive HIV-1 replication in latently infected CD4 lymphocytes from patients on suppressive cART.

Mary K. Lewinski, D. Richman, C. Spina, 2017, Virology.

Persistent HIV-1-specific cellular responses despite prolonged therapeutic viral suppression

D. Richman, S. Rowland-Jones, Steven Wolinsky, 2002, AIDS.

Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells

D. Richman, A. Varki, C. Spina, 2012, Journal of Molecular Medicine.

semen is associated with higher levels of proviral HIV DNA and CD 4 + T cell activation during antiretroviral treatment

R. Haubrich, D. Richman, S. Little, 2014 .

The Importance of nes in the Induction of Human Immunodeficiency Virus Type 1 Replication from Primary Quiescent CD 4 Lymphocytes

D. Richman, C. Spina, J. Guatelli, 2003 .

Optimal Infectivity InVitroofHumanImmunodeficiency Virus Type1Requires an Intact nefGene

D. Richman, C. Spina, N. Fitch, 1994 .

Dynamics of T Cell Responses in HIV

Louise Jones, Sarah Rowland-Jones, Andrew J. McMichael, 2013 .