N. Fertig

发表

Activity of single ion channel proteins detected with a planar microstructure

N. Fertig, M. Klau, M. George, 2002 .

Automated Patch Clamp Analysis of nAChα7 and NaV1.7 Channels

N. Fertig, M. George, A. Obergrussberger, 2014, Current protocols in pharmacology.

Investigation of the Ion Channels TMEM16A and TRPC5 and their Modulation by Intracellular Calcium

N. Fertig, M. George, Nina Brinkwirth, 2017 .

A biomimetic DNA-based channel for the ligand-controlled transport of charged molecular cargo across a biological membrane.

S. Howorka, N. Fertig, J. Burns, 2016, Nature nanotechnology.

Identification of Drug-Drug Interactions In Vitro: A Case Study Evaluating the Effects of Sofosbuvir and Amiodarone on hiPSC-Derived Cardiomyocytes.

Daniel C Millard, C. January, N. Fertig, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Automated Dynamic Clamp for Simulation of IK1 in Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes in Real Time Using Patchliner Dynamite8

N. Fertig, M. George, A. Obergrussberger, 2020, Current protocols in pharmacology.

Automated Patch Clamp Meets High-Throughput Screening

Michael George, Andrea Brüggemann, Claudia Haarmann, 2016, Journal of laboratory automation.

Automated ion channel screening: patch clamping made easy

Michael George, Cecilia Farre, Sonja Stoelzle, 2007, Expert opinion on therapeutic targets.

Adverse cardiotoxic side effects on contractility analyzed with impedance technology in a human stem cell-derived 3D model

Tobias Schwarzenberger, Sonja Stoelzle, Niels Fertig, 2014 .

An update on the advancing high-throughput screening techniques for patch clamp-based ion channel screens: implications for drug discovery

Michael George, Søren Friis, Andrea Brüggemann, 2018, Expert opinion on drug discovery.

Combined Impedance and Extracellular Field Potential Recordings from Human Stem Cell-Derived Cardiomyocytes

N. Fertig, M. George, A. Obergrussberger, 2017 .

Stable integration of isolated cell membrane patches in a nanomachined aperture: a step towards a novel device for membrane physiology

N. Fertig, R. Blick, J. Behrends, 1999, cond-mat/9910217.

Green Fluorescent Protein Changes the Conductance of Connexin 43 (Cx43) Hemichannels Reconstituted in Planar

N. Fertig, C. Steinem, O. Valerius, 2012 .

Green Fluorescent Protein Changes the Conductance of Connexin 43 (Cx43) Hemichannels Reconstituted in Planar Lipid Bilayers*

N. Fertig, A. Brüggemann, C. Steinem, 2011, The Journal of Biological Chemistry.

The patch-clamp on-chip technology

N. Fertig, R. Blick, J. Behrends, 2002 .

High-resolution electrophysiology on a chip: Transient dynamics of alamethicin channel formation.

Michael George, Markus Sondermann, Niels Fertig, 2006, Biochimica et biophysica acta.

Antibiotic translocation through porins studied in planar lipid bilayers using parallel platforms.

N. Fertig, J. Behrends, M. Winterhalter, 2015, The Analyst.

Permeation of Antibiotics through Escherichia coli OmpF and OmpC Porins

N. Fertig, M. Winterhalter, M. Kreir, 2010, Journal of biomolecular screening.

A Scalable Approach Reveals Functional Responses of iPSC Cardiomyocyte 3D Spheroids

N. Fertig, M. Haddrick, M. Burnham, 2020, SLAS discovery : advancing life sciences R & D.

Integration of mechanical conditioning into a high throughput contractility assay for cardiac safety assessment.

N. Fertig, M. George, S. Stoelzle-Feix, 2020, Journal of pharmacological and toxicological methods.

Automated Patch Clamp on mESC-Derived Cardiomyocytes for Cardiotoxicity Prediction

Ralf Kettenhofen, Heribert Bohlen, Michael George, 2011, Journal of biomolecular screening.

Minimized cell usage for stem cell-derived and primary cells on an automated patch clamp system.

N. Fertig, M. George, D. Malan, 2013, Journal of pharmacological and toxicological methods.

A novel cell-cycle-dependent 350-kDa nuclear protein: C-terminal domain sufficient for nuclear localization.

N. Fertig, H. Joshi, T. Medsger, 1995, Biochemical and biophysical research communications.

Automated patch clamp in drug discovery: major breakthroughs and innovation in the last decade

N. Fertig, A. Obergrussberger, S. Friis, 2020, Expert opinion on drug discovery.

SSM-based electrophysiology, a label-free real-time method reveals sugar binding & transport events in SGLT1.

N. Fertig, S. Kubick, A. Körner, 2021, Biosensors & bioelectronics.

There is no F in APC: Using physiological fluoride-free solutions for high throughput automated patch clamp experiments

T. Strassmaier, N. Fertig, A. Obergrussberger, 2022, Frontiers in Molecular Neuroscience.

Real-time monitoring β-lactam/β-lactamase inhibitor (BL/BLI) mixture towards the bacteria porin pathway at single molecule level

N. Fertig, Jiajun Wang, Yilun Ying, 2019, Analytical and Bioanalytical Chemistry.

A Hybrid Model for Safety Pharmacology on an Automated Patch Clamp Platform: Using Dynamic Clamp to Join iPSC-Derived Cardiomyocytes and Simulations of Ik1 Ion Channels in Real-Time

Nadine Becker, Niels Fertig, Teun P. de Boer, 2018, Front. Physiol..

Simultaneous optical and electrical recording of single gramicidin channels.

G. Schütz, N. Fertig, J. Behrends, 2003, Biophysical journal.

Membrane assembly of the functional KcsA potassium channel in a vesicle-based eukaryotic cell-free translation system.

N. Fertig, A. Brüggemann, S. Kubick, 2014, Biosensors & bioelectronics.

Constructing semantic representations using the MDL principle

N. Fertig, G. Scheler, 1997 .

Functional characterization of SGLT1 using SSM-based electrophysiology: Kinetics of sugar binding and translocation

N. Fertig, Maria Barthmes, Andre Bazzone, 2023, Frontiers in Physiology.

Bilayer-Spanning DNA Nanopores with Voltage-Switching between Open and Closed State

Stefan Howorka, Jonathan R. Burns, Niels Fertig, 2014, ACS nano.

A novel gain-of-function mutation of Piezo1 is functionally affirmed in red blood cells by high-throughput patch clamp

N. Fertig, Nadine Becker, Markus Rapedius, 2018, Haematologica.

Whole cell patch clamp recording performed on a planar glass chip.

Robert H Blick, Niels Fertig, N. Fertig, 2002, Biophysical journal.

The M34A mutant of Connexin26 reveals active conductance states in pore-suspending membranes.

N. Fertig, G. Sosinsky, C. Steinem, 2009, Journal of structural biology.

New strategies in ion channel screening for drug discovery: are there ways to improve its productivity?

Niels Fertig, Cecilia Farre, N. Fertig, 2014, Expert opinion on drug discovery.

Minimized cell usage for stem cell-derived and primary cells on an automated patch clamp system.

Ralf Kettenhofen, Heribert Bohlen, Michael George, 2013, Journal of pharmacological and toxicological methods.

Characterizing Human Ion Channels in Induced Pluripotent Stem Cell–Derived Neurons

Michael George, Sonja Stoelzle, Andrea Brüggemann, 2012, Journal of biomolecular screening.

HTS techniques for patch clamp-based ion channel screening – advances and economy

Niels Fertig, Cecilia Farre, N. Fertig, 2012, Expert opinion on drug discovery.

Port-a-patch and patchliner: high fidelity electrophysiology for secondary screening and safety pharmacology.

Michael George, Cecilia Farre, Sonja Stoelzle, 2009, Combinatorial chemistry & high throughput screening.

Microchip technology for automated and parallel patch-clamp recording.

Sonja Stoelzle, Andrea Brüggemann, Niels Fertig, 2006, Small.

A modern automated patch-clamp approach for high throughput electrophysiology recordings in native cardiomyocytes

N. Fertig, Nadine Becker, Markus Rapedius, 2022, Communications Biology.

Planar patch-clamp force microscopy on living cells.

Michael George, Niels Fertig, Evren Pamir, 2008, Ultramicroscopy.

Temperature-sensitive gating of hCx26: high-resolution Raman spectroscopy sheds light on conformational changes.

Bernhard Roth, Niels Fertig, Merve Meinhardt-Wollweber, 2014, Biomedical optics express.

Planar patch clamp: advances in electrophysiology.

Michael George, Cecilia Farre, Sonja Stoelzle, 2008, Methods in molecular biology.

Probing whole cell currents in high-frequency electrical fields: identification of thermal effects.

F. Simmel, N. Fertig, S. Manus, 2008, Biosensors & bioelectronics.

Microstructured glass chip for ion-channel electrophysiology.

C. Trautmann, N. Fertig, R. Blick, 2001, Physical review. E, Statistical, nonlinear, and soft matter physics.

New Easy-to-Use Hybrid System for Extracellular Potential and Impedance Recordings

Niels Fertig, Corina T. Bot, Ulrich Thomas, 2015, Journal of laboratory automation.

Rapid screening of membrane protein activity: electrophysiological analysis of OmpF reconstituted in proteoliposomes.

Michael George, Cecilia Farre, Niels Fertig, 2008, Lab on a chip.

Miniaturized planar lipid bilayer: increased stability, low electric noise and fast fluid perfusion

Mathias Winterhalter, Niels Fertig, Jürgen Fritz, 2008, Analytical and bioanalytical chemistry.

Planar Patch Clamping

Niels Fertig, N. Fertig, J. Behrends, 2007 .

Exciting new impedance and automated patch clamp for safety screening and drug discovery

Michael George, Tobias Schwarzenberger, Sonja Stoelzle, 2014 .

Safety pharmacology studies using EFP and impedance.

Michael George, Niels Fertig, Nadine Becker, 2016, Journal of pharmacological and toxicological methods.

Novel screening techniques for ion channel targeting drugs

Andrea Brüggemann, Niels Fertig, Nadine Becker, 2015, Channels.

State-of-the-Art Automated Patch Clamp Devices: Heat Activation, Action Potentials, and High Throughput in Ion Channel Screening

Ralf Kettenhofen, Michael George, Sonja Stoelzle, 2011, Front. Pharmacol..

Automated Patch Clamp Recordings of Human Stem Cell-Derived Cardiomyocytes

Michael George, Andrea Brüggemann, Claudia Haarmann, 2017 .

Ion channel drug discovery and research: the automated Nano-Patch-Clamp technology.

N. Fertig, M. Klau, M. George, 2004, Current drug discovery technologies.

Microstructured apertures in planar glass substrates for ion channel research.

Robert H Blick, Michael George, Niels Fertig, 2003, Receptors & channels.

The suitability of high throughput automated patch clamp for physiological applications

N. Fertig, A. Obergrussberger, Nadine Becker, 2021, The Journal of physiology.

Renaissance of ion channel research and drug discovery by patch clamp automation.

Cecilia Farre, Niels Fertig, N. Fertig, 2010, Future medicinal chemistry.

Ion channel screening - automated patch clamp on the rise.

Michael George, Cecilia Farre, Niels Fertig, 2008, Drug discovery today. Technologies.

Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles.

Tim Liedl, Wolfgang J Parak, Teresa Pellegrino, 2005, Nano letters.

Detection of lipid bilayer and peptide pore formation at gigahertz frequencies

Friedrich C. Simmel, Michael George, Andrea Brüggemann, 2006 .

Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment.

N. Fertig, A. Obergrussberger, Nadine Becker, 2020, Journal of pharmacological and toxicological methods.

A Comparative Study on the Lysosomal Cation Channel TMEM175 Using Automated Whole-Cell Patch-Clamp, Lysosomal Patch-Clamp, and Solid Supported Membrane-Based Electrophysiology: Functional Characterization and High-Throughput Screening Assay Development

D. Stone, J. Renger, N. Fertig, 2023, International journal of molecular sciences.

Unraveling the kinetics and pharmacology of human PepT1 using solid supported membrane-based electrophysiology.

N. Fertig, S. Kubick, S. Dondapati, 2023, Bioelectrochemistry.

Probing lipid membranes and ion channels with high frequency spectroscopy

F. Simmel, N. Fertig, M. George, 2004, 4th IEEE Conference on Nanotechnology, 2004..

Antibiotic translocation through porins studied in planar lipid bilayers using parallel platforms.

N. Fertig, J. Behrends, M. Winterhalter, 2015, In Analysis.

A high-throughput electrophysiology assay to study the response of PIEZO1 to mechanical stimulation

N. Fertig, Markus Rapedius, D. Beech, 2023, The Journal of general physiology.

Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment.

N. Fertig, A. Obergrussberger, Nadine Becker, 2021, Journal of pharmacological and toxicological methods.