J. McMillan

发表

Macrophage endocytic trafficking of antiretroviral nanoparticles.

H. Gendelman, Irena Kadiu, Ari S. Nowacek, 2011, Nanomedicine.

H. Gendelman, J. McMillan, M. Boska, 2014, Nanomedicine.

"While biomaterials, sensors, nanoparticles, and nanospheres are potential platforms for drug and gene delivery for nanoneuromedicines, few are fully developed for human use, and each hold a number of challenges."

H. Gendelman, J. McMillan, M. Boska, 2014 .

Bench-to-bedside translation of magnetic nanoparticles.

Alexander V. Kabanov, Dhirender Singh, Howard Eliot Gendelman, 2014, Nanomedicine.

Chemical exchange saturation transfer for detection of antiretroviral drugs in brain tissue

H. Gendelman, J. McMillan, Aditya N Bade, 2021, bioRxiv.

Bioimaging predictors of rilpivirine biodistribution and antiretroviral activities.

H. Gendelman, J. McMillan, R. Mosley, 2018, Biomaterials.

Neurotheranostics as personalized medicines.

H. Gendelman, J. McMillan, T. Bronich, 2019, Advanced drug delivery reviews.

Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues

H. Gendelman, J. McMillan, R. Vachet, 2020, Theranostics.

Cell delivery of therapeutic nanoparticles.

H. Gendelman, J. McMillan, E. Batrakova, 2011, Progress in molecular biology and translational science.

Nanoformulated Antiretroviral Drug Combinations Extend Drug Release and Antiretroviral Responses in HIV-1-Infected Macrophages: Implications for NeuroAIDS Therapeutics

H. Gendelman, Ari S. Nowacek, J. McMillan, 2010, Journal of Neuroimmune Pharmacology.

Optimizing the preparation and stability of decorated antiretroviral drug nanocrystals

H. Gendelman, J. McMillan, N. Gautam, 2018, Nanomedicine.

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

H. Gendelman, J. McMillan, M. Boska, 2010, Journal of visualized experiments : JoVE.

Long-acting approaches for delivery of antiretroviral drugs for prevention and treatment of HIV: a review of recent research

J. McMillan, Benson J. Edagwa, Nathan A Smith, 2020, Expert opinion on drug delivery.

Transformation of tenofovir into stable ProTide nanocrystals with long-acting pharmacokinetic profiles

H. Gendelman, J. McMillan, Samuel M. Cohen, 2021, Nature Communications.

EFAVIRENZ, ATAZANAVIR, AND RITONAVIR DISRUPT SARCOPLASMIC RETICULUM Ca2+ HOMEOSTASIS IN SKELETAL MUSCLES.

H. Gendelman, J. McMillan, P. Dash, 2021, Antiviral research.

Creation of a Long-Acting Nanoformulated 2′,3′-Dideoxy-3′-Thiacytidine

H. Gendelman, J. McMillan, T. Bronich, 2016, Journal of acquired immune deficiency syndromes.

Magnetic resonance imaging of folic acid-coated magnetite nanoparticles reflects tissue biodistribution of long-acting antiretroviral therapy

H. Gendelman, J. McMillan, Gang Zhang, 2015, International journal of nanomedicine.

Pharmacotherapeutics of SARS-CoV-2 Infections

Channabasavaiah B. Gurumurthy, H. Gendelman, J. McMillan, 2021, Journal of Neuroimmune Pharmacology.

A Link Between Methylglyoxal and Heart Failure During HIV-1 Infection

H. Gendelman, J. McMillan, H. Fox, 2021, Frontiers in Cardiovascular Medicine.

Nanoformulated Antiretroviral Therapy Attenuates Brain Metabolic Oxidative Stress

G. Siuzdak, H. Gendelman, J. McMillan, 2018, Molecular Neurobiology.

Adeno-Associated Viral Transfer of Glyoxalase-1 Blunts Carbonyl and Oxidative Stresses in Hearts of Type 1 Diabetic Rats

J. McMillan, Jaipaul Singh, K. Bidasee, 2020, Antioxidants.

Expression of PPAR(alpha) in human hepatocytes and activation by trichloroacetate and dichloroacetate.

J. McMillan, D. T. Kurtz, J. Walgren, 2000, Research communications in molecular pathology and pharmacology.

Covalent binding of the flavonoid quercetin to human serum albumin.

J. McMillan, T. Walle, U. Walle, 2005, Journal of agricultural and food chemistry.

The Promise of Long-Acting Antiretroviral Therapies: From Need to Manufacture.

H. Gendelman, J. McMillan, Aditya N Bade, 2019, Trends in microbiology.

Development of HIV reservoir targeted long acting nanoformulated antiretroviral therapies.

H. Gendelman, J. McMillan, Benson J. Edagwa, 2014, Current medicinal chemistry.

Multimodal Theranostic Nanoformulations Permit Magnetic Resonance Bioimaging of Antiretroviral Drug Particle Tissue-Cell Biodistribution

H. Gendelman, J. McMillan, B. Sajja, 2018, Theranostics.

Lack of formic acid production in rat hepatocytes and human renal proximal tubule cells exposed to chloral hydrate or trichloroacetic acid.

C. J. Reed, J. McMillan, E. Lock, 2007, Toxicology.

Pharmacokinetic testing of a first-generation cabotegravir prodrug in rhesus macaques

H. Gendelman, J. McMillan, H. Fox, 2019, AIDS.

Contribution of 3,4-dichlorophenylhydroxylamine in propanil-induced hemolytic anemia.

J. McMillan, D. McMillan, D. Jollow, 1991, Advances in experimental medicine and biology.

Simultaneous quantification of intracellular lamivudine and abacavir triphosphate metabolites by LC–MS/MS

H. Gendelman, J. McMillan, N. Gautam, 2018, Journal of pharmaceutical and biomedical analysis.

A long acting nanoformulated lamivudine ProTide.

H. Gendelman, J. McMillan, N. Gautam, 2019, Biomaterials.

ProTide generated long-acting abacavir nanoformulations† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8cc04708a

H. Gendelman, J. McMillan, N. Gautam, 2018, Chemical communications.

Potential of N-acetylated-para-aminosalicylic acid to accelerate manganese enhancement decline for long-term MEMRI in rodent brain

H. Gendelman, J. McMillan, M. Boska, 2015, Journal of Neuroscience Methods.

Effect of R(+)α-Lipoic acid on pyruvate metabolism and fatty acid oxidation in rat hepatocytes☆

J. McMillan, M. Buse, Jennie L. Walgren, 2004 .

Effect of R(+)alpha-lipoic acid on pyruvate metabolism and fatty acid oxidation in rat hepatocytes.

J. McMillan, M. Buse, Jennie L. Walgren, 2004, Metabolism: clinical and experimental.

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

H. Gendelman, J. McMillan, K. Khalili, 2019, Nature Communications.

Induction of peroxisome proliferation in cultured hepatocytes by a series of halogenated acetates.

J. McMillan, D. Jollow, Jennie L. Walgren, 2004, Toxicology.

Development of mannose-anchored thiolated amphotericin B nanocarriers for treatment of visceral leishmaniasis

H. Gendelman, J. McMillan, S. Akhtar, 2016, Nanomedicine.

Cell-Based Drug Delivery for Improving Antiretroviral Therapeutic Outcomes

H. Gendelman, J. McMillan, 2014 .

Humanized Mice as a Platform for the Development of Long-Acting Nanoformulated Antiretroviral Therapy

H. Gendelman, J. McMillan, 2014 .

Neuropathogenesis of human immunodeficiency virus infection.

H. Gendelman, J. McMillan, Christopher J. Woldstad, 2018, Handbook of clinical neurology.

Diagnostics for SARS-CoV-2 infections

H. Gendelman, J. McMillan, M. Hasan, 2021, Nature Materials.

Nanoneuromedicines for degenerative, inflammatory, and infectious nervous system diseases.

H. Gendelman, B. Narasimhan, S. Mallapragada, 2015, Nanomedicine : nanotechnology, biology, and medicine.

Long-acting antituberculous therapeutic nanoparticles target macrophage endosomes

H. Gendelman, J. McMillan, Benson J. Edagwa, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Development of europium doped core-shell silica cobalt ferrite functionalized nanoparticles for magnetic resonance imaging.

Howard E Gendelman, H. Gendelman, J. McMillan, 2017, Acta biomaterialia.

Macrophage folate receptor-targeted antiretroviral therapy facilitates drug entry, retention, antiretroviral activities and biodistribution for reduction of human immunodeficiency virus infections.

H. Gendelman, J. McMillan, A. Kabanov, 2013, Nanomedicine : nanotechnology, biology, and medicine.

Application of Cryopreserved Human Hepatocytes in Trichloroethylene Risk Assessment: Relative Disposition of Chloral Hydrate to Trichloroacetate and Trichloroethanol

J. McMillan, D. Hoel, L. Mohr, 2006, Environmental health perspectives.

A Year-Long Extended Release Nanoformulated Cabotegravir Prodrug

J. Meza, H. Gendelman, J. McMillan, 2020, Nature Materials.

Creation of a long-acting rilpivirine prodrug nanoformulation.

H. Gendelman, J. McMillan, H. Fox, 2019, Journal of controlled release : official journal of the Controlled Release Society.

S-adenosylmethionine but not glutathione protects against galactosamine-induced cytotoxicity in rat hepatocyte cultures.

J. McMillan, D. McMillan, 2006, Toxicology.

Galactosamine hepatotoxicity: effect of galactosamine on glutathione resynthesis in rat primary hepatocyte cultures.

J. McMillan, D. Jollow, 1992, Toxicology and applied pharmacology.

Synthesis and characterization of a long-acting emtricitabine prodrug nanoformulation

H. Gendelman, J. McMillan, N. Gautam, 2019, International journal of nanomedicine.

Endosomal Trafficking of Nanoformulated Antiretroviral Therapy Facilitates Drug Particle Carriage and HIV Clearance

Beata J. Wysocki, Howard E. Gendelman, Gang Zhang, 2014, Journal of Virology.

Synthesis of a long acting nanoformulated emtricitabine ProTide.

H. Gendelman, J. McMillan, N. Gautam, 2019, Biomaterials.

Europium sulfide nanoprobes predict antiretroviral drug delivery into HIV-1 cell and tissue reservoirs

H. Gendelman, J. McMillan, M. Hasan, 2021, Nanotheranostics.

Lipophilic nanocrystal prodrug-release defines the extended pharmacokinetic profiles of a year-long cabotegravir

H. Gendelman, J. McMillan, N. Gautam, 2021, Nature Communications.

Preclinical Pharmacokinetics and Tissue Distribution of Long-Acting Nanoformulated Antiretroviral Therapy

H. Gendelman, J. McMillan, H. Fox, 2013, Antimicrobial Agents and Chemotherapy.

Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles

H. Gendelman, J. McMillan, H. Fox, 2017, Biomaterials.

Creation of a long-acting nanoformulated dolutegravir

H. Gendelman, J. McMillan, P. Dash, 2018, Nature Communications.

Macrophage enhancement of galactosamine hepatotoxicity using a rat hepatocyte culture system.

J. McMillan, D. Jollow, 1995, Research communications in molecular pathology and pharmacology.

Lack of direct mitogenic activity of dichloroacetate and trichloroacetate in cultured rat hepatocytes.

J. McMillan, D. T. Kurtz, Jennie L. Walgren, 2005, Toxicology.

Galactosamine decreases nitric oxide formation in cultured rat hepatocytes: Lack of involvement in cytotoxicity

J. McMillan, 1999, Journal of biochemical and molecular toxicology.

Taxol metabolism in rat hepatocytes.

J. McMillan, T. Walle, U. Walle, 1993, Biochemical pharmacology.

Pharmacodynamics of folic acid receptor targeted antiretroviral nanotherapy in HIV-1-infected humanized mice.

H. Gendelman, J. McMillan, P. Dash, 2015, Antiviral research.

Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs

H. Gendelman, J. McMillan, H. Gelbard, 2017, The Journal of clinical investigation.

Dexamethasone induction of taxol metabolism in the rat.

J. McMillan, T. Walle, U. Walle, 1995, Drug metabolism and disposition: the biological fate of chemicals.

Neuroimmune cross talk and HIV-associated neurocognitive disorders

H. Gendelman, J. McMillan, 2013 .

Endosomal Trafficking of Nanoformulated Antiretroviral Therapy 2

Harris, H. Gendelman, J. McMillan, 2014 .

Particle Carriage and HIV Clearance Antiretroviral Therapy Facilitates Drug Endosomal Trafficking of Nanoformulated

H. Gendelman, J. McMillan, T. Wysocki, 2014 .

Enabling nanomaterial, nanofabrication and cellular technologies for nanoneuromedicines.

Anup D. Sharma, H. Gendelman, B. Narasimhan, 2015, Nanomedicine : nanotechnology, biology, and medicine.

Nanomedicines for nervous system diseases

H. Gendelman, J. McMillan, Dongwei Guo, 2014 .

UPLC-MS/MS quantification of nanoformulated ritonavir, indinavir, atazanavir, and efavirenz in mouse serum and tissues.

H. Gendelman, J. McMillan, N. Gautam, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Differential stability of drug-metabolizing enzyme activities in primary rat hepatocytes, cultured in the absence or presence of dexamethasone.

M. P. Arlotto, J. McMillan, J. Shaddock, 1991, Mutation research.

NanoART synthesis, characterization, uptake, release and toxicology for human monocyte-macrophage drug delivery.

H. Gendelman, Ari S. Nowacek, J. McMillan, 2009, Nanomedicine.

Transformation of dolutegravir into an ultra-long-acting parenteral prodrug formulation

H. Gendelman, J. McMillan, A. Dahan, 2022, Nature Communications.

Creation of a long-acting nanoformulated dolutegravir

H. Gendelman, J. McMillan, P. Dash, 2018, Nature Communications.

Modulating cellular autophagy for controlled antiretroviral drug release.

H. Gendelman, J. McMillan, H. Gelbard, 2018, Nanomedicine.

Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery.

H. Gendelman, B. Narasimhan, S. Mallapragada, 2018, Journal of biomedical materials research. Part A.

EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment

H. Gendelman, J. McMillan, O. Arancio, 2018, PLoS pathogens.

Antiretroviral Drug Metabolism in Humanized PXR-CAR-CYP3A-NOG Mice

H. Gendelman, J. McMillan, Donald W. Harms, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Dolutegravir Inhibition of Matrix Metalloproteinases Affects Mouse Neurodevelopment

H. Gendelman, J. McMillan, Yutong Liu, 2021, Molecular Neurobiology.

Metabolism of the arylamide herbicide propanil. II. Effects of propanil and its derivatives on hepatic microsomal drug-metabolizing enzymes in the rat.

M. P. Arlotto, J. McMillan, D. McMillan, 1990, Toxicology and applied pharmacology.

Comparative manufacture and cell-based delivery of antiretroviral nanoformulations

H. Gendelman, Ari S. Nowacek, J. McMillan, 2011, International journal of nanomedicine.

CRISPR-Cas9 Mediated Exonic Disruption for HIV-1 Elimination

H. Gendelman, J. McMillan, R. Mosley, 2021, EBioMedicine.

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

H. Gendelman, J. McMillan, K. Khalili, 2019, Nature Communications.

Long-acting slow effective release antiretroviral therapy

H. Gendelman, J. McMillan, Benson J. Edagwa, 2017, Expert opinion on drug delivery.

Opposing regulation of endolysosomal pathways by long-acting nanoformulated antiretroviral therapy and HIV-1 in human macrophages

H. Gendelman, J. McMillan, P. Ciborowski, 2015, Retrovirology.

Functional proteome of macrophage carried nanoformulated antiretroviral therapy demonstrates enhanced particle carrying capacity.

Han Liu, H. Xiong, H. Gendelman, 2013, Journal of proteome research.

Pharmacodynamics of long-acting folic acid-receptor targeted ritonavir-boosted atazanavir nanoformulations.

D. Dimitrov, H. Gendelman, J. McMillan, 2015, Biomaterials.

Macrophage Delivery of Nanoformulated Antiretroviral Drug to the Brain in a Murine Model of NeuroAIDS1

H. Gendelman, J. McMillan, C. Destache, 2009, The Journal of Immunology.

Model of NeuroAIDS Antiretroviral Drug to the Brain in a Murine Macrophage Delivery of Nanoformulated

H. Gendelman, J. McMillan, C. Destache, 2009 .

The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy.

H. Gendelman, J. McMillan, T. Wysocki, 2016, Nanomedicine : nanotechnology, biology, and medicine.

Pharmacodynamic and antiretroviral activities of combination nanoformulated antiretrovirals in HIV-1-infected human peripheral blood lymphocyte-reconstituted mice.

J. Meza, H. Gendelman, J. McMillan, 2012, The Journal of infectious diseases.

Rilpivirine-associated aggregation-induced emission enables cell-based nanoparticle tracking.

A. Mohs, H. Gendelman, J. McMillan, 2019, Biomaterials.

Development and characterization of a long-acting nanoformulated abacavir prodrug.

H. Gendelman, J. McMillan, Dhirender Singh, 2016, Nanomedicine.

Pharmacokinetics, Biodistribution, and Toxicity of Folic Acid-Coated Antiretroviral Nanoformulations

H. Gendelman, J. McMillan, H. Fox, 2014, Antimicrobial Agents and Chemotherapy.

Cellular Responses and Tissue Depots for Nanoformulated Antiretroviral Therapy

H. Gendelman, J. McMillan, R. Mosley, 2015, PloS one.

Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice

H. Gendelman, J. McMillan, H. Gelbard, 2012, AIDS.

Synthesis and Characterization of Long Acting Darunavir Prodrugs.

H. Gendelman, J. McMillan, N. Gautam, 2019, Molecular pharmaceutics.

Pharmacokinetics of a Long-Acting Nanoformulated Dolutegravir Prodrug in Rhesus Macaques

H. Gendelman, J. McMillan, H. Fox, 2017, Antimicrobial Agents and Chemotherapy.

Analyses of nanoformulated antiretroviral drug charge, size, shape and content for uptake, drug release and antiviral activities in human monocyte-derived macrophages.

H. Gendelman, Ari S. Nowacek, J. McMillan, 2011, Journal of controlled release : official journal of the Controlled Release Society.

Formulation design facilitates magnetic nanoparticle delivery to diseased cells and tissues.

H. Gendelman, J. McMillan, M. Sokolsky-Papkov, 2014, Nanomedicine.

Small magnetite antiretroviral therapeutic nanoparticle probes for MRI of drug biodistribution.

H. Gendelman, J. McMillan, B. Sajja, 2014, Nanomedicine.

Pharmacotoxicology of monocyte-macrophage nanoformulated antiretroviral drug uptake and carriage

H. Gendelman, Ari S. Nowacek, J. McMillan, 2011, Nanotoxicology.

Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs

H. Gendelman, Ari S. Nowacek, J. McMillan, 2010, Journal of visualized experiments : JoVE.

Exonic Disruption Facilitates Antiviral CRISPR-Cas9 Activity for Multistrain HIV-1 Elimination

H. Gendelman, J. McMillan, M. Hasan, 2021, bioRxiv.

BL-1023 improves behavior and neuronal survival in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice

H. Gendelman, J. McMillan, R. Mosley, 2011, Neuroscience.

Nanoformulated Antiretroviral Therapy Attenuates Brain Metabolic Oxidative Stress

G. Siuzdak, H. Gendelman, J. McMillan, 2018, Molecular Neurobiology.

A systematic literature review of the prevalence, distribution, exposure, and human health risks of tire microplastics and the contribution of their physicochemically diverse properties

J. McMillan, Luke Glastad, 2023 .

Mononuclear phagocyte intercellular crosstalk facilitates transmission of cell-targeted nanoformulated antiretroviral drugs to human brain endothelial cells

H. Gendelman, J. McMillan, A. Kabanov, 2012, International journal of nanomedicine.

The effect of the trichloroethylene metabolites trichloroacetate and dichloroacetate on peroxisome proliferation and DNA synthesis in cultured human hepatocytes

J. McMillan, D. T. Kurtz, J. Walgren, 2004, Cell Biology and Toxicology.

Dichloroacetic acid induction of peroxisome proliferation in cultured hepatocytes

J. McMillan, D. T. Kurtz, Jennie L. Everhart, 1998, Journal of biochemical and molecular toxicology.

Nanomedicine and Neurodegenerative Disorders

H. Gendelman, Ari S. Nowacek, J. McMillan, 2011 .

Pathways for Dolutegravir Transformation from a Daily Oral to a Once-a-Year Parenteral Medicine

H. Gendelman, J. McMillan, A. Dahan, 2022 .

Pharmacodynamics of folic acid receptor targeted antiretroviral nanotherapy in HIV-1-infected humanized mice.

J. McMillan, R. Mosley, S. Gorantla, 2015, Antiviral research.

Enabling nanomaterial, nanofabrication and cellular technologies for nanoneuromedicines.

Anup D. Sharma, H. Gendelman, B. Narasimhan, 2015, Nanomedicine : nanotechnology, biology, and medicine.

NanoART synthesis, characterization, uptake, release and toxicology for human monocyte-macrophage drug delivery.

Ari S. Nowacek, J. McMillan, R. Mosley, 2009, Nanomedicine.