N. Alp

N. Alp, K. Channon, D. Taggart, 2004, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Reversal of Cardiac Hypertrophy and Fibrosis From Pressure Overload by Tetrahydrobiopterin: Efficacy of Recoupling Nitric Oxide Synthase as a Therapeutic Strategy

James B. Mitchell, D. Kass, M. Halushka, 2008, Circulation.

Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia

F. Ruschitzka, N. Alp, K. Channon, 2007, Heart.

Candida prosthetic valve endocarditis cured by caspofungin therapy without valve replacement.

R. Rajendram, N. Alp, J. Forfar, 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Pivotal Role for Endothelial Tetrahydrobiopterin in Pulmonary Hypertension

K. Rockett, N. Alp, K. Channon, 2005, Circulation.

Unique Blood Pressure Characteristics in Mother and Offspring After Early Onset Preeclampsia

L. Mackillop, Y. Kenworthy, N. Alp, 2012, Hypertension.

Vertical transmission of human immunodeficiency virus.

N. Alp, J. Morrison, 1997, QJM : monthly journal of the Association of Physicians.

Endothelial Arginase II: A Novel Target for the Treatment of Atherosclerosis

A. Shoukas, N. Alp, D. Christianson, 2008, Circulation research.

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation

N. Alp, K. Channon, S. Cai, 2005, Diabetologia.

Severe endothelial dysfunction in the aorta of a mouse model of Fabry disease; partial prevention by N-butyldeoxynojirimycin treatment

R. Dwek, K. Clarke, A. Kulkarni, 2007, Journal of Inherited Metabolic Disease.

N. Alp, K. Channon, R. Schrier, 2008, American journal of physiology. Renal physiology.

Stoichiometric Relationships Between Endothelial Tetrahydrobiopterin, Endothelial NO Synthase (eNOS) Activity, and eNOS Coupling in Vivo Insights From Transgenic Mice With Endothelial-Targeted GTPCH and eNOS Overexpression

K. Rockett, N. Alp, K. Channon, 2005 .

Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure.

D. Kass, N. Alp, K. Channon, 2011, Journal of molecular and cellular cardiology.

Relationships between nitric oxide‐mediated endothelial function, eNOS coupling and blood pressure revealed by eNOS–GTP cyclohydrolase 1 double transgenic mice

N. Alp, K. Channon, D. Adlam, 2007, Experimental physiology.

Increased Endothelial Tetrahydrobiopterin Synthesis by Targeted Transgenic GTP-Cyclohydrolase I Overexpression Reduces Endothelial Dysfunction and Atherosclerosis in ApoE-Knockout Mice

N. Alp, K. Channon, R. Choudhury, 2004, Arteriosclerosis, thrombosis, and vascular biology.

GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation.

N. Alp, K. Channon, S. Heales, 2002, Cardiovascular research.

Cardiomyocyte GTP Cyclohydrolase 1 and Tetrahydrobiopterin Increase NOS1 Activity and Accelerate Myocardial Relaxation

A. Hale, M. Crabtree, N. Alp, 2012, Circulation research.

GTP Cyclohydrolase I Expression, Protein, and Activity Determine Intracellular Tetrahydrobiopterin Levels, Independent of GTP Cyclohydrolase Feedback Regulatory Protein Expression

M. Crabtree, N. Alp, K. Channon, 2009, Journal of Biological Chemistry.

Altered Plasma Versus Vascular Biopterins in Human Atherosclerosis Reveal Relationships Between Endothelial Nitric Oxide Synthase Coupling, Endothelial Function, and Inflammation

M. Crabtree, N. Alp, K. Channon, 2007, Circulation.

Cell-Autonomous Role of Endothelial GTP Cyclohydrolase 1 and Tetrahydrobiopterin in Blood Pressure Regulation

G. Douglas, A. Hale, E. McNeill, 2014, Hypertension.

Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status

A. Hale, M. Crabtree, N. Alp, 2009, Journal of Biological Chemistry.

Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth

G. Douglas, A. Hale, E. McNeill, 2021, Hypertension.

Lipid lowering effects of the CETP inhibitor obicetrapib in combination with high-intensity statins: a randomized phase 2 trial

N. Alp, J. Kastelein, M. Davidson, 2022, Nature Medicine.

Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension.

Deepak L. Bhatt, N. Alp, Y. Halvorsen, 2022, The New England journal of medicine.

Acute myocarditis mimicking reverse Takotsubo cardiomyopathy.

S. Neubauer, V. Ferreira, N. Alp, 2011, Circulation.

2 Hypertension July 2014 Methods For detailed Methods , see online-only Data Supplement . Generation of Endothelial Cell – Targeted GCH 1 Knockout Mice

G. Douglas, A. Hale, E. McNeill, 2022 .

Disseminated adenovirus infection after liver transplantation and its possible treatment with ganciclovir.

N. Alp, T. Wreghitt, J. Gray, 1989, The Journal of infection.

QJM Vertical transmission of human immunodeficiency virus

N. Alp, J. Morrison, 2022 .

Role of Chlamydia pneumoniae in atherosclerosis.

Nicholas J Alp, N. Alp, Caroline Watson, 2008, Clinical science.

CCR2-Mediated Antiinflammatory Effects of Endothelial Tetrahydrobiopterin Inhibit Vascular Injury–Induced Accelerated Atherosclerosis

D. Greaves, G. Douglas, E. McNeill, 2008, Circulation.

Randomised comparison of antero-lateral versus antero-posterior paddle positions for DC cardioversion of persistent atrial fibrillation.

N. Alp, M. Shahi, J. Bell, 2000, International journal of cardiology.

Randomised double blind trial of oral versus intravenous flecainide for the cardioversion of acute atrial fibrillation

N. Alp, M. Shahi, J. Bell, 2000, Heart.

Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease.

N. Alp, Tim S. Schmidt, 2007, Clinical science.

High frequency of memory and effector gag specific cytotoxic T lymphocytes in HIV seropositive individuals.

D. Nixon, A. McMichael, N. Alp, 1990, International immunology.

Critical Role for Tetrahydrobiopterin Recycling by Dihydrofolate Reductase in Regulation of Endothelial Nitric-oxide Synthase Coupling

A. Hale, M. Crabtree, N. Alp, 2009, The Journal of Biological Chemistry.

Fine specificity of cellular immune responses in humans to human cytomegalovirus immediate-early 1 protein

N. Alp, J. Sissons, L. Borysiewicz, 1991, Journal of virology.

Increased in-stent stenosis in ApoE knockout mice: insights from a novel mouse model of balloon angioplasty and stenting.

D. Greaves, Z. Ali, N. Alp, 2007, Arteriosclerosis, thrombosis, and vascular biology.

Early change in invasive measures of microvascular function can predict myocardial recovery following PCI for ST-elevation myocardial infarction.

B. Prendergast, S. Neubauer, V. Ferreira, 2014, European heart journal.

Stoichiometric Relationships Between Endothelial Tetrahydrobiopterin, Endothelial NO Synthase (eNOS) Activity, and eNOS Coupling in Vivo: Insights From Transgenic Mice With Endothelial-Targeted GTP Cyclohydrolase 1 and eNOS Overexpression

K. Rockett, N. Alp, K. Channon, 2005, Circulation research.

Models for studying coronary artery stenting

Z. Ali, N. Alp, K. Channon, 2006 .

Reduced Vascular NO Bioavailability in Diabetes Increases Platelet Activation In Vivo

S. Neubauer, N. Alp, K. Channon, 2004, Arteriosclerosis, thrombosis, and vascular biology.

Elevated Blood Pressure in Offspring Born Premature to Hypertensive Pregnancy: Is Endothelial Dysfunction the Underlying Vascular Mechanism?

S. Neubauer, N. Alp, A. Lucas, 2010, Hypertension.

Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding

Gary Shaw, Nicholas J. Alp, N. Alp, 2009, PloS one.

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.

K. Rockett, N. Alp, K. Channon, 2003, The Journal of clinical investigation.

Spontaneous aortic thrombosis causing left main coronary occlusion in a man with secondary polycythemia.

N. Alp, S. Munir, N. Shah, 2011, JACC. Cardiovascular interventions.

GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function.

N. Alp, K. Channon, C. Stefanadis, 2008, Journal of the American College of Cardiology.

Endothelium-Specific GTP Cyclohydrolase I Overexpression Attenuates Blood Pressure Progression in Salt-Sensitive Low-Renin Hypertension

N. Alp, K. Channon, Y. Guan, 2008, Circulation.

Cardiac Papillary Fibroelastoma Presenting with Recurrent Ventricular Tachycardia

N. Alp, S. Westaby, K. Asrress, 2007, Pacing and clinical electrophysiology : PACE.

Increased intimal hyperplasia in experimental vein graft stenting compared to arterial stenting: comparisons in a new rabbit model of stent injury.

N. Alp, K. Channon, J. Gunn, 2002, Cardiovascular research.

Comparison of low-density lipoprotein cholesterol equations in patients with dyslipidaemia receiving cholesterol ester transfer protein inhibition

J. Kastelein, N. Alp, S. Martin, 2022, European heart journal. Cardiovascular pharmacotherapy.

Radiochemical HPLC detection of arginine metabolism: measurement of nitric oxide synthesis and arginase activity in vascular tissue.

N. Alp, K. Channon, N. Warrick, 2007, Nitric oxide : biology and chemistry.

Obicetrapib Lowers LDL-C in Patients Taking High Intensity Statins - Results from the ROSE Clinical Trial

N. Alp, Michael H. Davidson, M. Ditmarsch, 2022, Journal of Clinical Lipidology.

Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection.

N. Alp, K. Channon, R. Migrino, 2010, American journal of physiology. Heart and circulatory physiology.

A requirement for Gch1 and tetrahydrobiopterin in embryonic development

G. Douglas, A. Hale, M. Crabtree, 2015, Developmental biology.

Increased endothelial tetrahydrobiopterin synthesis reduces vein graft atherosclerosis in ApoE-knockout mice

D. Greaves, Z. Ali, N. Alp, 2005 .

Automation of limiting dilution cytotoxicity assays.

N. Alp, J. Sissons, L. Borysiewicz, 1990, Journal of immunological methods.

A Specific Role for eNOS-Derived Reactive Oxygen Species in Atherosclerosis Progression

K. Hirata, N. Alp, K. Channon, 2007, Arteriosclerosis, thrombosis, and vascular biology.

Atrial Sources of Reactive Oxygen Species Vary With the Duration and Substrate of Atrial Fibrillation: Implications for the Antiarrhythmic Effect of Statins

U. Schotten, N. Alp, K. Channon, 2011, Circulation.

Cardiomyocyte-targeted overexpression of GTP cyclohydrolase-1 increases nNOS activity and hastens myocardial relaxation

A. Hale, N. Alp, K. Channon, 2011 .

Early change in invasive measures of microvascular function can predict myocardial recovery following PCI for ST-elevation myocardial infarction.

B. Prendergast, S. Neubauer, V. Ferreira, 2014, European heart journal.

Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse.

Janice M. Fullerton, J. Flint, N. Alp, 2004, Molecular genetics and metabolism.

Randomised double blind trial of oral versus intravenous flecainide for the cardioversion of acute atrial fibrillation

N. Alp, M. Shahi, J. Bell, 2000, Heart.