P. Quax

J. Hamming, P. Quax, W. Fibbe, 2011, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

Blocking Toll-Like Receptors 7 and 9 Reduces Postinterventional Remodeling via Reduced Macrophage Activation, Foam Cell Formation, and Migration

J. Hamming, J. Jukema, P. Quax, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Toll-Like Receptor 4 Is Involved in Human and Mouse Vein Graft Remodeling, and Local Gene Silencing Reduces Vein Graft Disease in Hypercholesterolemic APOE*3Leiden Mice

J. Jukema, P. Quax, J. Fischer, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Annexin A5 reduces infarct size and improves cardiac function after myocardial ischemia-reperfusion injury by suppression of the cardiac inflammatory response

Niek J. Pluijmert, D. Atsma, J. Jukema, 2018, Scientific Reports.

Plasminogen activators, their inhibitors, and urokinase receptor emerge in late stages of melanocytic tumor progression.

P. Quax, H. Verspaget, U. Weidle, 1994, The American journal of pathology.

Short-Term Preoperative Protein Restriction Attenuates Vein Graft Disease via Induction of Cystathionine ϒ-Lyase.

B. Lambrecht, P. Quax, A. Longchamp, 2019, Cardiovascular research.

P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3*Leiden Mice via Systemic Inhibition of Regulatory T Cells

J. Jukema, P. Quax, R. Arens, 2021, Frontiers in Cardiovascular Medicine.

The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development

J. Jukema, P. Quax, C. Gongora, 2017, PloS one.

Research ethics needs fine tuning, not rigidity: how to promote evidence in neglected patient populations by rethinking informed consent.

D. P. Engberts, J. Jukema, P. Quax, 2015, European heart journal.

MicroRNA-411 and Its 5'-IsomiR Have Distinct Targets and Functions and Are Differentially Regulated in the Vasculature under Ischemia.

P. Quax, A. Y. Nossent, R. V. van der Kwast, 2020, Molecular therapy : the journal of the American Society of Gene Therapy.

Endotoxin induction of plasminogen activator and plasminogen activator inhibitor type 1 mRNA in rat tissues in vivo.

P. Quax, T. V. van Berkel, J. Kuiper, 1990, The Journal of biological chemistry.

Accelerated Atherosclerosis and Calcification in Vein Grafts

P. Quax, J. Cleutjens, J. H. Bockel, 2002 .

Accelerated atherosclerosis by placement of a perivascular cuff and a cholesterol-rich diet in ApoE*3Leiden transgenic mice.

P. Quax, J. H. van Bockel, V. V. van Hinsbergh, 2000, Circulation research.

Fibrinogen reduction and coagulation in cardiac surgery: an investigational study

P. Quax, J. Grimbergen, R. Klautz, 2015, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Plaque Rupture Complications in Murine Atherosclerotic Vein Grafts Can Be Prevented by TIMP-1 Overexpression

J. Hamming, J. Jukema, P. Quax, 2012, PloS one.

Adenosine-to-Inosine Editing of MicroRNA-487b Alters Target Gene Selection After Ischemia and Promotes Neovascularization

P. Quax, L. Parma, H. Peters, 2017, Circulation research.

Variations in surgical procedures for hind limb ischaemia mouse models result in differences in collateral formation.

J. Hamming, P. Quax, L. Seghers, 2010, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

Elastin is a key regulator of outward remodeling in arteriovenous fistulas.

J. Hamming, P. Quax, T. Rabelink, 2015, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

Urokinase and tissue-type plasminogen activator stimulate human vascular smooth muscle cell migration*

P. Quax, J. Verheijen, M. Wijnberg, 1996 .

Loss of Endothelial Glycocalyx Hyaluronan Impairs Endothelial Stability and Adaptive Vascular Remodeling after Arterial Ischemia

P. Quax, T. Rabelink, A. V. van Zonneveld, 2020, Cells.

von Willebrand factor deficiency leads to impaired blood flow recovery after ischaemia in mice

P. Quax, M. D. de Vries, E. Peters, 2017, Thrombosis and Haemostasis.

TLR4 Accessory Molecule RP105 (CD180) Regulates Monocyte-Driven Arteriogenesis in a Murine Hind Limb Ischemia Model

J. Hamming, P. Quax, A. V. van Zonneveld, 2014, PloS one.

fibrin-collagen matrix Membrane-type matrix metalloproteinase-mediated angiogenesis in a

P. Quax, P. Koolwijk, R. Hanemaaijer, 2013 .

Phosphorylcholine Antibodies Preserve Cardiac Function and Reduce Infarct Size by Attenuating the Post-Ischemic Inflammatory Response

Niek J. Pluijmert, D. Atsma, J. Jukema, 2020, JACC. Basic to translational science.

Lipocalin-2 contributes to experimental atherosclerosis in a stage-dependent manner.

P. Quax, J. Kuiper, I. Bot, 2018, Atherosclerosis.

Activation of the innate immune system in atherosclerotic disease.

P. Quax, G. Pasterkamp, D. D. de Kleijn, 2007, Current pharmaceutical design.

Chapter 5 Hypercholesterolemia Reduces Collateral Artery Growth More Dominantly than Hyperglycemia or Insulin Resistance in Mice

P. Eilers, P. Quax, P. Voshol, 2008 .

Vascular Endothelial Growth Factor Overexpression in Ischemic Skeletal Muscle Enhances Myoglobin Expression In Vivo

P. Quax, J. H. van Bockel, V. V. van Hinsbergh, 2004 .

Absence of Chemokine (C-X-C Motif) Ligand 10 Diminishes Perfusion Recovery After Local Arterial Occlusion in Mice

P. Quax, G. Pasterkamp, D. D. de Kleijn, 2014, Arteriosclerosis, thrombosis, and vascular biology.

Short hairpin RNA gene silencing of prolyl hydroxylase-2 with a minicircle vector improves neovascularization of hindlimb ischemia.

J. Hamming, P. Quax, Joseph C. Wu, 2014, Human gene therapy.

Soluble ST2 levels are not associated with secondary cardiovascular events and vulnerable plaque phenotype in patients with carotid artery stenosis.

P. Quax, F. Moll, G. Pasterkamp, 2013, Atherosclerosis.

Mast cells in human carotid atherosclerotic plaques are associated with intraplaque microvessel density and the occurrence of future cardiovascular events.

P. Quax, F. Moll, G. Pasterkamp, 2013, European heart journal.

Soluble ST 2 levels are not associated with secondary cardiovascular events and vulnerable plaque phenotype in patients with carotid artery stenosis

P. Quax, F. Moll, G. Pasterkamp, 2022 .

Hypercholesterolemia affects cardiac function, infarct size and inflammation in APOE*3-Leiden mice following myocardial ischemia-reperfusion injury

Niek J. Pluijmert, D. Atsma, P. Quax, 2019, PloS one.

Vaccination Against VEGFR2 Attenuates Initiation and Progression of Atherosclerosis

P. Quax, T. V. van Berkel, J. Kuiper, 2007 .

Involvement of furin-like proprotein convertases in the arterial response to injury.

M. Goumans, J. Sluijter, P. Quax, 2005, Cardiovascular research.

In Vivo Evidence for a Role of Toll-Like Receptor 4 in the Development of Intimal Lesions

J. Sluijter, P. Quax, G. Pasterkamp, 2002, Circulation.

The role of mast cells in atherosclerosis

P. Quax, J. Kuiper, I. Bot, 2014, Hämostaseologie.

Epigenetics in atherosclerosis and inflammation

J. Jukema, P. Quax, Rutger J. Wierda, 2010, Journal of cellular and molecular medicine.

Identification of a Novel Anti-Atherogenic Function for TLR2/PI3K-Signaling

P. Quax, J. Kuiper, I. Bot, 2015 .

Dexamethasone-eluting stents for the prevention of in-stent restenosis: evidence for a differential effect in insulin-dependent and non-insulin-dependent diabetic patients.

H. Putter, J. Jukema, P. Quax, 2008, International journal of cardiology.

RP105 deficiency aggravates cardiac dysfunction after myocardial infarction in mice.

P. Quax, P. Steendijk, J. A. Smit, 2014, International journal of cardiology.

VLDL receptor deficiency enhances intimal thickening after vascular injury but does not affect atherosclerotic lesion area.

P. Quax, K. V. van Dijk, L. Havekes, 2002, Atherosclerosis.

Adenosine-to-Inosine Editing of Vasoactive MicroRNAs Alters Their Targetome and Function in Ischemia

P. Quax, M. D. de Vries, A. Y. Nossent, 2020, Molecular therapy. Nucleic acids.

Effects of infection with recombinant adenovirus on human vascular endothelial and smooth muscle cells

M. Lamfers, P. Quax, J. Grimbergen, 1996 .

Circulating tRNA Fragments as a Novel Biomarker Class to Distinguish Acute Stroke Subtypes

P. Quax, E. V. van Zwet, M. Wermer, 2020, International journal of molecular sciences.

Lipoprotein lipase gene polymorphisms and the risk of target vessel revascularization after percutaneous coronary intervention.

A. Zwinderman, R. D. de Winter, J. Kastelein, 2005, Journal of the American College of Cardiology.

Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease.

J. Jukema, P. Quax, B. Heijmans, 2008, European heart journal.

Generation of a novel replication-incompetent adenoviral vector derived from human adenovirus type 49: manufacture on PER.C6 cells, tropism and immunogenicity.

B. Berkhout, P. Quax, M. Havenga, 2006, The Journal of general virology.

Neovascularization capacity of mesenchymal stromal cells from critical limb ischemia patients is equivalent to healthy controls.

P. Quax, M. Verhaar, H. Gremmels, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

Strain-dependent susceptibility for hypertension in mice resides in the natural killer gene complex.

P. Quax, L. Brewster, G. V. van Montfrans, 2010, American journal of physiology. Heart and circulatory physiology.

9 C 1-esterase inhibitor protects against early vein graft remodeling under arterial blood pressure

P. Quax, P. Krijnen, L. Eijsman, 2014 .

C1-esterase inhibitor protects against early vein graft remodeling under arterial blood pressure.

P. Quax, V. V. van Hinsbergh, P. Krijnen, 2012, Atherosclerosis.

The role of CD27-CD70-mediated T cell co-stimulation in vasculogenesis, arteriogenesis and angiogenesis.

Suzanne P. M. Welten, J. Hamming, J. Jukema, 2018, International journal of cardiology.

Replication-Deficient Human Adenovirus Type 35 Vectors for Gene Transfer and Vaccination: Efficient Human Cell Infection and Bypass of Preexisting Adenovirus Immunity

S. Kostense, P. Quax, M. Havenga, 2003, Journal of Virology.

Activation of Nuclear Receptor Nur77 by 6-Mercaptopurine Protects Against Neointima Formation

P. Quax, J. Jukema, H. Pannekoek, 2007, Circulation.

Both MIP-1α and RANTES and their receptors are expressed in murine vein grafts and aggravate vein graft remodeling

P. Quax, H. Anders, I. Bot, 2008 .

Metabolic profile in endothelial cells of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension

M. Cascante, V. Peinado, P. Quax, 2022, Scientific reports.

Expression of Vascular Endothelial Growth Factor, Stromal Cell-Derived Factor-1, and CXCR4 in Human Limb Muscle With Acute and Chronic Ischemia

P. Quax, J. H. van Bockel, V. V. van Hinsbergh, 2007, Arteriosclerosis, thrombosis, and vascular biology.

Properties of metastasizing and nonmetastasizing human melanoma cells.

P. Quax, E. Danen, J. Verheijen, 1995, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Chapter 2 Future potential biomarkers for post-interventional restenosis and accelerated atherosclerosis

J. Jukema, P. Quax, M. M. Ewing, 2013 .

Plasminogen activator and matrix metalloproteinase production and extracellular matrix degradation by rat prostate cancer cells in vitro: Correlation with metastatic behavior in vivo

P. Quax, J. Schalken, J. Verheijen, 1997, The Prostate.

Heat‐killed Staphylococcus aureus reduces atherosclerosis by inducing anti‐inflammatory macrophages

P. Quax, J. Kuiper, I. Bot, 2016, Journal of internal medicine.

Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease.

J. Hamming, P. Quax, T. Woodruff, 2013, Cardiovascular research.

Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice

P. Quax, J. Knuuti, S. Ylä-Herttuala, 2020, JACC. Basic to translational science.

Components of the plasminogen activation system in uveal melanoma—a clinico‐pathological study

P. Quax, H. Verspaget, U. Weidle, 1995, The Journal of pathology.

Toll-like Receptor 4 Inhibitor TAK-242 Treatment Does Not Influence Perfusion Recovery in Tissue Ischemia

P. Quax, G. Pasterkamp, I. Hoefer, 2014, Journal of cardiovascular pharmacology.

In vivo suppression of vein graft disease by nonviral, electroporation-mediated, gene transfer of tissue inhibitor of metalloproteinase-1 linked to the amino terminal fragment of urokinase (TIMP-1.ATF), a cell-surface directed matrix metalloproteinase inhibitor.

P. Quax, J. H. van Bockel, J. Grimbergen, 2010, Journal of vascular surgery.

Prolonged in vivo gene silencing by electroporation-mediated plasmid delivery of small interfering RNA.

R. Moon, P. Quax, J. H. van Bockel, 2007, Human gene therapy.

Anti–MCP-1 Gene Therapy Inhibits Vascular Smooth Muscle Cells Proliferation and Attenuates Vein Graft Thickening Both In Vitro and In Vivo

P. Quax, J. H. van Bockel, J. Grimbergen, 2006, Arteriosclerosis, thrombosis, and vascular biology.

Attenuates Vein Graft Thickening Both in Vitro and in Vivo Mcp-1 Gene Therapy Inhibits Vascular Smooth Muscle Cells Proliferation and − Anti

P. Quax, J. H. van Bockel, J. Grimbergen, 2022 .

Metastatic behavior of human melanoma cell lines in nude mice correlates with urokinase-type plasminogen activator, its type-1 inhibitor, and urokinase-mediated matrix degradation

P. Quax, L. Lund, K. Danø, 1991, The Journal of cell biology.

Inhibition of Accelerated Atherosclerosis in Vein Grafts by Placement of External Stent in ApoE*3-Leiden Transgenic Mice

P. Quax, J. H. van Bockel, V. V. van Hinsbergh, 2002, Arteriosclerosis, thrombosis, and vascular biology.

Systemic Upregulation of IL-10 (Interleukin-10) Using a Nonimmunogenic Vector Reduces Growth and Rate of Dissecting Abdominal Aortic Aneurysm

P. Tsao, J. Hamming, P. Quax, 2018, Arteriosclerosis, thrombosis, and vascular biology.

Consensus guidelines for the use and interpretation of angiogenesis assays

Robert J. Griffin, Federico Bussolino, Mark J. Post, 2018, Angiogenesis.

Local Mast Cell Activation Promotes Neovascularization

P. Quax, J. Kuiper, I. Bot, 2020, Cells.

IRF3 and IRF7 mediate neovascularization via inflammatory cytokines

J. Jukema, P. Quax, M. D. de Vries, 2019, Journal of cellular and molecular medicine.

Bone matrix degradation by the plasminogen activation system. Possible mechanism of bone destruction in arthritis.

H. Ronday, F. Breedveld, P. Quax, 1997, British journal of rheumatology.

Impaired cardiac function in hypercholesterolemic APOE * 3-Leiden mice after myocardial ischemia-reperfusion injury despite reduced infarct size and inflammation

Niek J. Pluijmert, D. Atsma, P. Quax, 2016 .

Gene Transfer of Tissue Inhibitor of Metalloproteinases-3 Reverses the Inhibitory Effects of TNF-α on Fas-Induced Apoptosis in Rheumatoid Arthritis Synovial Fibroblasts1

P. Quax, T. Huizinga, M. Naumann, 2005, The Journal of Immunology.

Rheumatoid Arthritis Synovial Fibroblasts on Fas-Induced Apoptosis α Effects of TNF-Metalloproteinases-3 Reverses the Inhibitory Gene Transfer of Tissue Inhibitor of Thomas

P. Quax, T. Huizinga, M. Naumann, 2005 .

Critical Role of Tissue Kallikrein in Vessel Formation and Maturation: Implications for Therapeutic Revascularization

D. Bates, P. Quax, A. Al Haj Zen, 2009, Arteriosclerosis, thrombosis, and vascular biology.

Vascular remodeling and intimal hyperplasia in a novel murine model of arteriovenous fistula failure.

P. Quax, A. Vahrmeijer, T. Rabelink, 2014, Journal of vascular surgery.

Short-term dexamethasone treatment inhibits vein graft thickening in hypercholesterolemic ApoE3Leiden transgenic mice.

P. Quax, J. H. van Bockel, A. Schepers, 2006, Journal of vascular surgery.

Complementation between urokinase-producing and receptor-producing cells in extracellular matrix degradation.

P. Quax, F. Blasi, K. Danø, 1991, Cell regulation.

Different effects of lipopolysaccharide on plasminogen activator inhibitor-1 production in aortic media in vivo and in culture

P. Quax, A. Maseri, F. Andreotti, 2004, Journal of Thrombosis and Thrombolysis.

Exploiting the Natural Diversity in Adenovirus Tropism for Therapy and Prevention of Disease

P. Quax, T. Logtenberg, M. Mehtali, 2002, Journal of Virology.

Prevention of Disease Adenovirus Tropism for Therapy and Exploiting the Natural Diversity in

P. Quax, T. Logtenberg, M. Havenga, 2001 .

The Effect of Corticosteroids on Human Choroidal Endothelial Cells: A Model to Study Central Serous Chorioretinopathy.

R. Tsonaka, P. Quax, O. Meijer, 2018, Investigative ophthalmology & visual science.

Novel Replication-Incompetent Vector Derived from Adenovirus Type 11 (Ad11) for Vaccination and Gene Therapy: Low Seroprevalence and Non-Cross-Reactivity with Ad5

B. Berkhout, P. Quax, M. Havenga, 2004, Journal of Virology.

Antibodies to PAI-1 alter the invasive and migratory properties of human tumour cells in vitro

P. Quax, P. Charlton, J. Verheijen, 2004, Clinical & Experimental Metastasis.

Binding of human urokinase-type plasminogen activator to its receptor: residues involved in species specificity and binding.

P. Quax, D. Belin, V. V. van Hinsbergh, 1998, Arteriosclerosis, thrombosis, and vascular biology.

Differential regulation of plasminogen activation in normal keratinocytes and SCC-4 cells by fibroblasts.

P. Quax, M. Ponec, J. Verheijen, 1995, The Journal of investigative dermatology.

Protein and messenger RNA levels of plasminogen activators and inhibitors analyzed in 22 human tumor cell lines.

P. Quax, H. Verspaget, J. Verheijen, 1990, Cancer research.

TR3 nuclear orphan receptor prevents cyclic stretch-induced proliferation of venous smooth muscle cells.

P. Quax, V. de Waard, B. D. de Mol, 2006, The American journal of pathology.

Circulating MicroRNAs Characterizing Patients with Insufficient Coronary Collateral Artery Function

P. Quax, J. Piek, N. van Royen, 2015, PloS one.

The 14q32 MicroRNA-487b Targets the Antiapoptotic Insulin Receptor Substrate 1 in Hypertension-Induced Remodeling of the Aorta

J. Hamming, P. Quax, J. L. Hansen, 2013, Annals of surgery.

A Novel Murine Model of Arteriovenous Fistula Failure: The Surgical Procedure in Detail.

J. Hamming, P. Quax, A. Vahrmeijer, 2016, Journal of visualized experiments : JoVE.

Pericellular proteases in angiogenesis and vasculogenesis.

P. Quax, M. Engelse, V. V. van Hinsbergh, 2006, Arteriosclerosis, thrombosis, and vascular biology.

Tissue-type plasminogen activator and its inhibitor in rat aorta. Effect of endotoxin.

P. Quax, P. Roholl, J. Verheijen, 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

Toll-Like Receptor 4 Is Involved in Outward Arterial Remodeling

P. Quax, G. Pasterkamp, D. D. de Kleijn, 2004, Circulation.

Simultaneous detection of NOS-3 protein expression and nitric oxide production using a flow cytometer.

P. Quax, M. Havenga, A. Bout, 2001, Analytical biochemistry.

6-Mercaptopurine Inhibits Atherosclerosis in Apolipoprotein E*3-Leiden Transgenic Mice Through Atheroprotective Actions on Monocytes and Macrophages

P. Quax, V. de Waard, A. V. van Kuilenburg, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Human CD46-transgenic mice in studies involving replication-incompetent adenoviral type 35 vectors.

P. Quax, G. Weverling, M. Havenga, 2006, The Journal of general virology.

An Emerging Role for isomiRs and the microRNA Epitranscriptome in Neovascularization

P. Quax, A. Y. Nossent, R. V. van der Kwast, 2019, Cells.

SNPs in microRNA binding sites in 3'-UTRs of RAAS genes influence arterial blood pressure and risk of myocardial infarction.

P. Quax, F. Rosendaal, J. L. Hansen, 2011, American journal of hypertension.

The Prebiotic Inulin Aggravates Accelerated Atherosclerosis in Hypercholesterolemic APOE*3-Leiden Mice

P. Quax, A. Pronk, K. Willems van Dijk, 2018, Nutrients.

Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis

P. Quax, T. Rabelink, H. Baelde, 2008, Journal of cellular and molecular medicine.

Endoglin/CD105-Based Imaging of Cancer and Cardiovascular Diseases: A Systematic Review

L. de Geus-Oei, M. Goumans, P. Quax, 2021, International journal of molecular sciences.

Epigenetic control of CCR5 transcript levels in immune cells and modulation by small molecules inhibitors

J. Jukema, P. Quax, J. Jukema, 2012, Journal of cellular and molecular medicine.

Role of Endothelial Plasminogen Activators in Fibrinolysis and Repair-Associated Angiogenesis

P. Quax, T. Kooistra, P. Koolwijk, 1998 .

Metabolic Alterations in Cardiopulmonary Vascular Dysfunction

M. Cascante, J. Barberà, P. Quax, 2019, Front. Mol. Biosci..

BMP Receptor Inhibition Enhances Tissue Repair in Endoglin Heterozygous Mice

M. Goumans, P. Quax, K. Wiesmeijer, 2021, International journal of molecular sciences.

Genetic Inflammatory Factors Predict Restenosis After Percutaneous Coronary Interventions

A. Zwinderman, D. Atsma, R. D. de Winter, 2005, Circulation.

Complement factor C5a induces atherosclerotic plaque disruptions

P. Quax, J. Kuiper, I. Bot, 2014, Journal of cellular and molecular medicine.

TR3 Orphan Receptor Is Expressed in Vascular Endothelial Cells and Mediates Cell Cycle Arrest

P. Quax, J. Grimbergen, C. D. de Vries, 2003, Arteriosclerosis, thrombosis, and vascular biology.

The Multifaceted Functions of CXCL10 in Cardiovascular Disease

P. Quax, G. Pasterkamp, I. Hoefer, 2014, BioMed research international.

Akkermansia muciniphila Exerts Lipid‐Lowering and Immunomodulatory Effects without Affecting Neointima Formation in Hyperlipidemic APOE*3‐Leiden.CETP Mice

M. Netea, W. D. de Vos, P. Quax, 2019, Molecular nutrition & food research.

Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation[S]

R. Heeren, P. Quax, T. V. van Berkel, 2013, Journal of Lipid Research.

Molecular imaging of the urokinase plasminogen activator receptor: opportunities beyond cancer

L. de Geus-Oei, P. Quax, P. Kuppen, 2020, EJNMMI Research.

Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix.

P. Quax, V. V. van Hinsbergh, P. Koolwijk, 2003, Blood.

Plasminogen activators are involved in keratinocyte and fibroblast migration in wounded cultures in vitro

P. Quax, M. Ponec, J. Verheijen, 1994 .

Systemic MCP1/CCR2 blockade and leukocyte specific MCP1/CCR2 inhibition affect aortic aneurysm formation differently.

P. Quax, V. de Waard, T. V. van Berkel, 2010, Atherosclerosis.

ATVB In Focus Novel Mediators and Mechanisms in Angiogenesis and Vasculogenesis

P. Quax, M. Engelse, V. Hinsbergh, 2006 .

The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions

P. Quax, T. Hoffmann, W. Jagla, 2011, EMBO molecular medicine.

Cardiovascular metabolic syndrome: mediators involved in the pathophysiology from obesity to coronary heart disease.

J. Jukema, P. Quax, C. J. Roos, 2012, Biomarkers in medicine.

T-cell co-stimulation by CD28-CD80/86 and its negative regulator CTLA-4 strongly influence accelerated atherosclerosis development.

J. Jukema, P. Quax, J. Kuiper, 2011, International journal of cardiology.

MicroRNA-126 modulates endothelial SDF-1 expression and mobilization of Sca-1(+)/Lin(-) progenitor cells in ischaemia.

P. Quax, T. Rabelink, A. V. van Zonneveld, 2011, Cardiovascular research.

Quaking, an RNA-Binding Protein, Is a Critical Regulator of Vascular Smooth Muscle Cell Phenotype

M. Goumans, S. Richard, J. Jukema, 2013, Circulation research.

Liposomal prednisolone inhibits vascular inflammation and enhances venous outward remodeling in a murine arteriovenous fistula model

Alexander L. Vahrmeijer, Ton J. Rabelink, Joris I. Rotmans, 2016, Scientific Reports.

Genetic and Molecular Biology Techniques for the Assessment of Vascular Disease

P. Quax, M. P. Maat, V. V. Hinsbergh, 1997 .

Vascular growth in ischemic limbs: a review of mechanisms and possible therapeutic stimulation.

P. Quax, J. H. van Bockel, V. V. van Hinsbergh, 2008, Annals of vascular surgery.

Vein graft failure: from pathophysiology to clinical outcomes

J. Jukema, P. Quax, M. D. de Vries, 2016, Nature Reviews Cardiology.

Annexin A5 prevents post-interventional accelerated atherosclerosis development in a dose-dependent fashion in mice.

J. Jukema, P. Quax, J. Karper, 2012, Atherosclerosis.

Annexin A5 reduces infarct size and improves cardiac function after myocardial ischemia-reperfusion injury by suppression of the cardiac inflammatory response

Niek J. Pluijmert, D. Atsma, J. Jukema, 2018, Scientific Reports.

Post-ischemic Myocardial Inflammatory Response: A Complex and Dynamic Process Susceptible to Immunomodulatory Therapies

Niek J. Pluijmert, D. Atsma, P. Quax, 2021, Frontiers in Cardiovascular Medicine.

Effects on cardiac function, remodeling and inflammation following myocardial ischemia–reperfusion injury or unreperfused myocardial infarction in hypercholesterolemic APOE*3-Leiden mice

Niek J. Pluijmert, D. Atsma, P. Quax, 2020, Scientific Reports.

Arteriovenous access failure: more than just intimal hyperplasia?

P. Quax, T. Rabelink, A. V. van Zonneveld, 2013, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Shear induced collateral artery growth modulated by endoglin but not by ALK1

M. Goumans, P. Quax, B. Hierck, 2012, Journal of cellular and molecular medicine.

Adenoviral Activin A Expression Prevents Intimal Hyperplasia in Human and Murine Blood Vessels by Maintaining the Contractile Smooth Muscle Cell Phenotype

M. Lamfers, P. Quax, M. Engelse, 2002, Circulation research.

CD8+ T Cells Protect During Vein Graft Disease Development

J. Jukema, P. Quax, R. Arens, 2019, Front. Cardiovasc. Med..

Vaccination against VEGFR2 attenuates initiation and progression of atherosclerosis.

P. Quax, T. V. van Berkel, J. Kuiper, 2006, Arteriosclerosis, thrombosis, and vascular biology.

The protective role of Toll-like receptor 3 and type-I interferons in the pathophysiology of vein graft disease.

J. Hamming, J. Jukema, P. Quax, 2018, Journal of molecular and cellular cardiology.

Innate Immunity and Vein Graft Disease

J. Jukema, P. Quax, M. D. de Vries, 2016 .

Posttranscriptional Regulation of 14q32 MicroRNAs by the CIRBP and HADHB during Vascular Regeneration after Ischemia

P. Quax, J. Rappsilber, S. Welten, 2018, Molecular therapy. Nucleic acids.

CCR7‐CCL19/CCL21 Axis is Essential for Effective Arteriogenesis in a Murine Model of Hindlimb Ischemia

P. Quax, S. D. de Jager, M. D. de Vries, 2017, Journal of the American Heart Association.

The lysine acetyltransferase PCAF is a key regulator of arteriogenesis

J. Hamming, J. Jukema, P. Quax, 2013 .

Natural Killer Cells and CD4+ T-Cells Modulate Collateral Artery Development

P. Eilers, P. Quax, J. H. van Bockel, 2007, Arteriosclerosis, thrombosis, and vascular biology.

Hypercholesterolemia Reduces Collateral Artery Growth More Dominantly Than Hyperglycemia or Insulin Resistance in Mice

P. Eilers, P. Quax, J. H. van Bockel, 2006, Arteriosclerosis, thrombosis, and vascular biology.

Studies on functional and structural role of urokinase receptor and other components of the plasminogen activation system in malignancy.

P. Quax, U. Weidle, M. Ploug, 1994, Annales de biologie clinique.

TR 3 Orphan Receptor Is Expressed in Vascular Endothelial Cells and Mediates Cell Cycle Arrest

P. Quax, J. Grimbergen, C. Bree, 2003 .

Lack of Fibronectin-EDA Promotes Survival and Prevents Adverse Remodeling and Heart Function Deterioration After Myocardial Infarction

Gerard Pasterkamp, Imo E Hoefer, Fatih Arslan, 2011, Circulation research.

Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases

J. Wouter Jukema, P. Quax, J. Kuiper, 2020, Journal of internal medicine.

Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo.

Mark M. Davis, J. Hamming, P. Quax, 2018, Cell stem cell.

Tissue inhibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix metalloproteinase activity in vivo without affecting antitumor efficacy in malignant glioma.

W. Vandertop, M. Lamfers, C. Tung, 2005, Cancer research.

Malignant Glioma without Affecting Antitumor Efficacy in In vivo Activity Oncolytic Adenovirus Inhibits Matrix Metalloproteinase Tissue Inhibitor of Metalloproteinase-3 Expression from an Updated

W. Vandertop, M. Lamfers, C. Tung, 2005 .

Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics

J. Hamming, P. Quax, A. Connolly, 2017, Cell reports.

Three-Dimensional Imaging of Intraplaque Neovascularization in a Mouse Model of Advanced Atherosclerosis

P. Quax, G. D. De Meyer, W. Martinet, 2020, Journal of Vascular Research.

The effect of interleukin-10 knock-out and overexpression on neointima formation in hypercholesterolemic APOE*3-Leiden mice.

T. Lagerweij, J. Jukema, P. Quax, 2007, Atherosclerosis.

Induction of cellular immunity against VEGFR2 by DNA vaccination attenuates atherosclerosis

P. Quax, J. Kuiper, R. Reisfeld, 2006 .

Drug-eluting stents studies in mice: do we need atherosclerosis to study restenosis?

J. Jukema, P. Quax, M. Daemen, 2006, Vascular pharmacology.

26 27 2 Nur 77 modulates hepatic lipid metabolism through suppression of SREBP-1 c activity

P. Quax, A. Groen, J. Meijers, 2009 .

Nur77 modulates hepatic lipid metabolism through suppression of SREBP1c activity.

P. Quax, A. Groen, J. Meijers, 2008, Biochemical and biophysical research communications.

Drug-eluting stents: results, promises and problems.

J Wouter Jukema, Martin J Schalij, J. Jukema, 2005, International journal of cardiology.

The Role of Immunomodulation in Vein Graft Remodeling and Failure

J. Jukema, P. Quax, M. D. de Vries, 2020, Journal of Cardiovascular Translational Research.

Bis(maltolato)oxovanadium(IV) Induces Angiogenesis via Phosphorylation of VEGFR2

P. Quax, M. D. de Vries, S. D. de Kimpe, 2020, International Journal of Molecular Sciences.

Plaque angiogenesis and its relation to inflammation and atherosclerotic plaque destabilization

P. Quax, M. D. de Vries, 2016, Current opinion in lipidology.

5 VEGFR 2 enhances microvessel leakiness in graft murine vein atherosclerotic plaques

J. Hamming, M. Goumans, P. Quax, 2014 .

Cultured rat aortic vascular smooth muscle cells digest naturally produced extracellular matrix. Involvement of plasminogen-dependent and plasminogen-independent pathways.

P. Quax, A. Maseri, C. Kluft, 1992, Circulation research.

Genetic determinants of adverse outcome (restenosis, malapposition and thrombosis) after stent implantation

J. Jukema, J. Verschuren, P. Quax, 2010 .

Involvement of aspartic and glutamic residues in kringle-2 of tissue-type plasminogen activator in lysine binding, fibrin binding and stimulation of activity as revealed by chemical modification and oligonucleotide-directed mutagenesis.

P. Quax, J. Verheijen, K. Marotti, 1990, Protein engineering.

Accelerated Atherosclerosis and Calcification in Vein Grafts: A Study in APOE*3 Leiden Transgenic Mice

P. Quax, J. H. van Bockel, V. V. van Hinsbergh, 2002, Circulation research.

The influence of established genetic variation in the haemostatic system on clinical restenosis after percutaneous coronary interventions

A. Zwinderman, R. D. de Winter, P. Quax, 2007, Thrombosis and Haemostasis.

Metabolic profile in endothelial cells of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension

M. Cascante, V. Peinado, J. Barberà, 2021, Scientific Reports.

Proteomic and Metabolomic Analysis of Smooth Muscle Cells Derived From the Arterial Media and Adventitial Progenitors of Apolipoprotein E–Deficient Mice

Manuel Mayr, Yanhua Hu, Basetti Madhu, 2008, Circulation research.

Exploring the choroidal vascular labyrinth and its molecular and structural roles in health and disease

P. Quax, O. Meijer, A. Bergen, 2021, Progress in Retinal and Eye Research.

The multifactorial nature of microRNAs in vascular remodelling.

P. Quax, S. Welten, A. Y. Nossent, 2016, Cardiovascular research.

Inflammation in Vein Graft Disease

Paul H. A. Quax, P. Quax, M. D. de Vries, 2018, Front. Cardiovasc. Med..

Murine models of myocardial and limb ischemia: diagnostic end-points and relevance to clinical problems.

Qingbo Xu, H. S. Struijker Boudier, M. Huijberts, 2006, Vascular pharmacology.

Matrix Metalloproteinases 2 and 3 Gene Polymorphisms and the Risk of Target Vessel Revascularization after Percutaneous Coronary Intervention: Is There Still Room for Determining Genetic Variation of MMPs for Assessment of an Increased Risk of Restenosis?

P. de Knijff, R. D. de Winter, J. Jukema, 2011, Disease markers.

Myostatin Inhibits Vascular Smooth Muscle Cell Proliferation and Local 14q32 microRNA Expression, But Not Systemic Inflammation or Restenosis

J. Jukema, P. Quax, M. D. de Vries, 2020, International journal of molecular sciences.

Treatment with intramuscular vascular endothelial growth factor gene compared with placebo for patients with diabetes mellitus and critical limb ischemia: a double-blind randomized trial.

A. Smit, P. Quax, G. Hospers, 2006, Human Gene Therapy.

Arterial Blood Pressure Induces Transient C4b-Binding Protein in Human Saphenous Vein Grafts.

P. Quax, A. Blom, H. Niessen, 2017, Annals of vascular surgery.

Histopathologic alterations following local delivery of dexamethasone to inhibit restenosis in murine arteries.

J. Jukema, P. Quax, A. Schepers, 2005, Cardiovascular research.

Genetic associations and regulation of expression indicate an independent role for 14q32 snoRNAs in Human Cardiovascular Disease.

S. le Cessie, J. Kastrup, J. Jukema, 2018, Cardiovascular Research.

Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies

A. Zwinderman, N. Sattar, R. D. de Winter, 2010, Heart.

Phosphorylcholine antibodies restrict infarct size and left ventricular remodelling by attenuating the unreperfused post‐ischaemic inflammatory response

Niek J. Pluijmert, D. Atsma, J. Jukema, 2021, Journal of cellular and molecular medicine.

Future potential biomarkers for postinterventional restenosis and accelerated atherosclerosis.

J. Jukema, P. Quax, J. Karper, 2012, Biomarkers in medicine.

TLR Accessory Molecule RP105 (CD180) Is Involved in Post-Interventional Vascular Remodeling and Soluble RP105 Modulates Neointima Formation

J. Jukema, P. Quax, E. Huizinga, 2013, PloS one.

Tumor necrosis factor- plays an important role in restenosis development

A. Zwinderman, R. J. Winter, E. Wall, 2005 .

Tumor necrosis factor-alpha plays an important role in restenosis development.

A. Zwinderman, R. D. de Winter, J. Jukema, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Inhibition of Complement Component C3 Reduces Vein Graft Atherosclerosis in Apolipoprotein E3–Leiden Transgenic Mice

P. Quax, J. H. van Bockel, M. Daha, 2006, Circulation.

A novel urokinase receptor-targeted inhibitor for plasmin and matrix metalloproteinases suppresses vein graft disease.

J. Jukema, P. Quax, J. H. van Bockel, 2010, Cardiovascular research.

Adenoviral delivery of a constitutively active retinoblastoma mutant inhibits neointima formation in a human explant model for vein graft disease.

M. Lamfers, P. Quax, V. V. van Hinsbergh, 2002, Vascular pharmacology.

An Unexpected Intriguing Effect of Toll-Like Receptor Regulator RP105 (CD180) on Atherosclerosis Formation With Alterations on B-Cell Activation

J. Jukema, P. Quax, J. Kuiper, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Plaque angiogenesis and intraplaque hemorrhage in atherosclerosis

P. Quax, M. D. de Vries, F. Baganha, 2017, European journal of pharmacology.

Antisense Oligonucleotide Inhibition of MicroRNA-494 Halts Atherosclerotic Plaque Progression and Promotes Plaque Stabilization

P. Quax, J. Kuiper, I. Bot, 2019, Molecular therapy. Nucleic acids.

Deficiency of TLR4 homologue RP105 aggravates outward remodeling in a murine model of arteriovenous fistula failure

P. Quax, A. V. van Zonneveld, I. Que, 2017, Scientific Reports.

RP105 deficiency attenuates early atherosclerosis via decreased monocyte influx in a CCR2 dependent manner.

P. Quax, J. Kuiper, I. Bot, 2015, Atherosclerosis.

CXCL1 microspheres: a novel tool to stimulate arteriogenesis

P. Quax, A. Wagenaar, D. Molin, 2016, Drug delivery.

cha p te r 9 genetic variation at the quaking locus associates with clinical restenosis after PcI and induces vascular smooth muscle cell dysfunction

A. Zwinderman, S. Richard, R. J. Winter, 2009 .

Tumor cells secrete an Angiogenic factor that stimulates basic fibroblast growth factor and Urokinase expression in Vascular Endothelial cells

P. Quax, G. D. Valle, D. Rifkin, 1994, Journal of cellular physiology.

Galectin-2 Induces a Proinflammatory, Anti-Arteriogenic Phenotype in Monocytes and Macrophages

P. Quax, N. van Royen, A. M. van der Laan, 2015, PloS one.

Blockade of vascular endothelial growth factor receptor 2 inhibits intraplaque haemorrhage by normalization of plaque neovessels

J. Hamming, R. Virmani, A. Finn, 2018, Journal of internal medicine.

Galectin-2 expression is dependent on the rs7291467 polymorphism and acts as an inhibitor of arteriogenesis.

P. Quax, K. Koch, J. Piek, 2012, European heart journal.

Leukotriene B4 Levels in Human Atherosclerotic Plaques and Abdominal Aortic Aneurysms

P. Quax, F. Moll, M. Kowala, 2014, PloS one.

Mast cells mediate neutrophil recruitment during atherosclerotic plaque progression.

P. Quax, J. Kuiper, I. Bot, 2015, Atherosclerosis.

The Inflammatory Profile of CTEPH-Derived Endothelial Cells Is a Possible Driver of Disease Progression

M. Goumans, J. Barberà, J. Jukema, 2021, Cells.

miRMap: Profiling 14q32 microRNA Expression and DNA Methylation Throughout the Human Vasculature

H. Putter, P. Quax, M. D. de Vries, 2019, Front. Cardiovasc. Med..

Anti-apoptotic serpins as therapeutics in cardiovascular diseases.

P. Quax, J. Kuiper, I. Bot, 2013, Cardiovascular & hematological disorders drug targets.

Local perivascular delivery of anti-restenotic agents from a drug-eluting poly(epsilon-caprolactone) stent cuff.

J. Jukema, P. Quax, W. Hennink, 2005, Biomaterials.

Clinical performance of drug-eluting stents with biodegradable polymeric coating: a meta-analysis and systematic review.

T. Stijnen, J. Jukema, T. Ahmed, 2011, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.

Protease-Activated Receptor (PAR)2, but Not PAR1, Is Involved in Collateral Formation and Anti-Inflammatory Monocyte Polarization in a Mouse Hind Limb Ischemia Model

J. Hamming, P. Reitsma, P. Quax, 2013, PloS one.

Deficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response

P. Quax, J. Kuiper, I. Bot, 2016, Scientific Reports.

10 interleukin 10 : a new risk marker for the development of restenosis after percutaneous coronary intervention

A. Zwinderman, R. J. Winter, P. Quax, 2006 .

Inhibition of 14q32 microRNA miR-495 reduces lesion formation, intimal hyperplasia and plasma cholesterol levels in experimental restenosis.

J. Jukema, P. Quax, S. Agrawal, 2017, Atherosclerosis.

Sirolimus and paclitaxel provoke different vascular pathological responses after local delivery in a murine model for restenosis on underlying atherosclerotic arteries

J. Jukema, P. Quax, M. D. de Vries, 2007, Heart.

RP105 deficiency aggravates vein graft disease and lesion instability via increased inflammation and mast cell activation

P. Quax, J. Kuiper, I. Bot, 2015 .