J. Siegfried

发表

CT based computerized identification and analysis of human airways: a review.

D. Gur, J. Pu, S. Gu, 2012, Medical physics.

Comprehensive genomic characterization of squamous cell lung cancers

Steven J. M. Jones, Joshua M. Stuart, Brian D. O’Connor, 2012, Nature.

Culture of primary lung tumors using medium conditioned by a lung carcinoma cell line

J. Siegfried, 1989, Journal of cellular biochemistry.

Unlocking Biomarker Discovery: Large Scale Application of Aptamer Proteomic Technology for Early Detection of Lung Cancer

Stephen A. Williams, L. Gold, Y. Miller, 2010, PloS one.

Sex and gender differences in lung cancer.

J. Siegfried, L. Stabile, 2003, The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia.

Diagnostic Accuracy of MALDI Mass Spectrometric Analysis of Unfractionated Serum in Lung Cancer

William L. Bigbee, Daniel C. Liebler, Yu Shyr, 2007, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Doubling times and CT screen–detected lung cancers in the Pittsburgh Lung Screening Study.

Steven Shapiro, David O Wilson, J. Siegfried, 2012, American journal of respiratory and critical care medicine.

Cytogenetic analysis of 63 non‐small cell lung carcinomas: Recurrent chromosome alterations amid frequent and widespread genomic upheaval

J. Siegfried, J. Testa, S. Litwin, 1994, Genes, chromosomes & cancer.

Multiplexed Analysis of Serum Cytokines as Biomarkers in Squamous Cell Carcinoma of the Head and Neck Patients

D. Landsittel, J. Siegfried, J. Grandis, 2005, The Laryngoscope.

Familial aggregation of breast cancer with early onset lung cancer

J. Siegfried, A. Schwartz, L. Weiss, 1999, Genetic epidemiology.

Expression of adrenomedullin in normal human lung and in pulmonary tumors.

J. Siegfried, M. Miller, F. Cuttitta, 1995, Endocrinology.

Comparative genomic hybridization analysis detects frequent, often high-level, overrepresentation of DNA sequences at 3q, 5p, 7p, and 8q in human non-small cell lung carcinomas.

S. Manoir, J. Siegfried, E. Gabrielson, 1997, Cancer research.

Chromosome abnormalities in human non-small cell lung cancer.

J. Siegfried, J. Testa, Jill M. Siegfried, 1992, Cancer research.

Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor

J. Siegfried, J. Grandis, S. Thomas, 2003, Oncogene.

Anti-EGFR Fibronectin Bispecific Chemically Self-Assembling Nanorings (CSANs) Induce Potent T cell Mediated Anti-Tumor Response and Downregulation of EGFR Signaling and PD-1/PD-L1 Expression

J. Siegfried, C. Wagner, Ozgun Kilic, 2020, bioRxiv.

Anti-EGFR Fibronectin Bispecific Chemically Self-Assembling Nanorings (CSANs) Induce Potent T-cell Mediated Anti-Tumor Response and Downregulation of EGFR Signaling and PD-1/PD-L1 Expression.

J. Siegfried, M. Distefano, C. Wagner, 2020, Journal of medicinal chemistry.

Recurrent deletions of specific chromosomal sites in 1p, 3p, 6q, and 9p in human malignant mesothelioma.

S. Jhanwar, J. Siegfried, J. Testa, 1993, Cancer research.

Genetic variation in ESR2 and estrogen receptor-beta expression in lung tumors.

R. Dhir, J. Siegfried, M. Romkes, 2013, Cancer epidemiology.

Influence of age and IB status after resection of node-negative non-small cell lung cancer.

J. Luketich, J. Siegfried, R. Landreneau, 2012, The Annals of thoracic surgery.

Human non-small cell lung tumors and cells derived from normal lung express both estrogen receptor alpha and beta and show biological responses to estrogen.

J. Luketich, J. Siegfried, S. Finkelstein, 2002, Cancer research.

Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells.

R. Dhir, J. Siegfried, D. Carlisle, 2007, Pulmonary pharmacology & therapeutics.

Prognosis Tumor Epidermal Growth Factor Receptor and EGFRPY 1068 Are Independent Prognostic Indicators for Head and Neck Squamous Cell Carcinoma

G. Mills, J. Siegfried, A. Egloff, 2012 .

Optimal threshold in CT quantification of emphysema

David Gur, Jill M. Siegfried, Jiantao Pu, 2012, European Radiology.

Epigenetic Repression of CCDC37 and MAP1B Links Chronic Obstructive Pulmonary Disease to Lung Cancer

J. Siegfried, J. Weissfeld, S. Belinsky, 2015, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Fluorescence bronchoscopic surveillance after curative surgical resection for non-small-cell lung cancer

J. Luketich, J. Siegfried, S. Dacic, 2000, Annals of Surgical Oncology.

Three-dimensional airway tree architecture and pulmonary function.

David Gur, Jiantao Pu, Joseph K Leader, 2012, Academic radiology.

Smoking Out Reproductive Hormone Actions in Lung Cancer

J. Siegfried, 2014, Molecular Cancer Research.

K-ras mutations in lung tumors from NNK-treated mice with lipopolysaccharide-elicited lung inflammation.

J. Siegfried, Xiaoping Liu, Jinling Yin, 2011, Anticancer research.

Increased levels of tumor-infiltrating lymphocytes are associated with improved recurrence-free survival in stage 1A non-small-cell lung cancer.

J. Luketich, J. Siegfried, S. Yousem, 2011, The Journal of surgical research.

Cross-Talk between Estrogen Receptor and Epidermal Growth Factor Receptor in Head and Neck Squamous Cell Carcinoma

J. Siegfried, A. Egloff, R. Seethala, 2009, Clinical Cancer Research.

Cross-Talk between Estrogen Receptor and Epidermal Growth Factor Receptor in Head and Neck Squamous Cell Carcinoma

J. Siegfried, A. Egloff, R. Seethala, 2009, Clinical Cancer Research.

HGF Airway Over-expression Leads to Enhanced Pulmonary Vascularization without Induction of VEGF.

J. Siegfried, A. López-Chávez, Cassandra Henry, 2012, Current angiogenesis.

Estrogen receptor pathways in lung cancer

J. Siegfried, L. Stabile, 2004, Current oncology reports.

Preclinical Evidence for Combined Use of Aromatase Inhibitors and NSAIDs as Preventive Agents of Tobacco‐Induced Lung Cancer

J. Siegfried, B. Kurland, B. Diergaarde, 2017, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Interaction between the estrogen receptor and fibroblast growth factor receptor pathways in non-small cell lung cancer

J. Siegfried, S. Dacic, L. Stabile, 2017, Oncotarget.

Combined Analysis of Estrogen Receptor β-1 and Progesterone Receptor Expression Identifies Lung Cancer Patients with Poor Outcome

R. Dhir, J. Siegfried, J. Grandis, 2010, Clinical Cancer Research.

Imaging , Diagnosis , Prognosis Combined Analysis of Estrogen Receptor b-1 and Progesterone Receptor Expression Identifies Lung Cancer Patients with Poor Outcome

R. Dhir, J. Siegfried, J. Grandis, 2010 .

Co-targeting c-Met and COX-2 Leads to Enhanced Inhibition of Lung Tumorigenesis in a Murine Model with Heightened Airway HGF

J. Siegfried, L. Stabile, D. Cunningham, 2014, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells.

J. Siegfried, J. Grandis, S. Thomas, 2005, Neoplasia.

Gastrin-Releasing Peptide Receptor Mediates Activation of the Epidermal Growth Factor Receptor in Lung Cancer Cells 1

J. Siegfried, J. Grandis, S. Thomas, 2005 .

Phase 1/2 study of rilotumumab (AMG 102), a hepatocyte growth factor inhibitor, and erlotinib in patients with advanced non–small cell lung cancer

M. Socinski, J. Siegfried, T. Burns, 2017, Cancer.

Gastrin-releasing peptide activates Akt through the epidermal growth factor receptor pathway and abrogates the effect of gefitinib.

J. Siegfried, J. Grandis, D. Carlisle, 2007, Experimental cell research.

RET Rearrangements in Lung Adenocarcinoma and Radiation

M. Socinski, J. Siegfried, S. Dacic, 2014, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Association of immunoreactive hepatocyte growth factor with poor survival in resectable non-small cell lung cancer.

L. Weissfeld, J. Siegfried, J. Testa, 1997, Cancer research.

Ability to culture resectable non-small cell lung carcinomas is correlated with recurrence.

J. Siegfried, J. Testa, S. Yousem, 1994, The Annals of thoracic surgery.

Detection of K-ras mutations in lung carcinomas: relationship to prognosis.

J. Siegfried, R. Weyant, R. Landreneau, 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

Detection of infrequent and multiple K-ras mutations in human tumors and tumor-adjacent tissues.

J. Siegfried, S. Finkelstein, T. Whiteside, 1997, Analytical biochemistry.

Prognostic value of specific KRAS mutations in lung adenocarcinomas.

J. Siegfried, J. Testa, P. Keohavong, 1997, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Detection of low‐fraction K‐ras mutations in primary lung tumors using a sensitive method

J. Luketich, J. Siegfried, J. Testa, 1997, International journal of cancer.

Activity of anti-erbB-2 recombinant toxin OLX-209 on lung cancer cell lines in the absence of erbB-2 gene amplification.

J. Siegfried, M. Oelkuct, R. Bird, 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

Regulation of endogenous gene expression in human non-small cell lung cancer cells by estrogen receptor ligands.

J. Siegfried, M. Nichols, P. Hershberger, 2005, Cancer research.

Signaling Pathways Involved in Cyclooxygenase-2 Induction by Hepatocyte Growth Factor in Non–Small-Cell Lung Cancer

J. Siegfried, L. Stabile, P. Q. de Oliveira, 2007, Molecular Pharmacology.

Gastrin-releasing peptide receptor-mediated autocrine growth in squamous cell carcinoma of the head and neck.

J. Siegfried, J. Grandis, M. Lango, 2002, Journal of the National Cancer Institute.

Chromosome alterations in 21 non‐small cell lung carcinomas

J. Siegfried, J. Testa, J. Resau, 1990, Genes, chromosomes & cancer.

Association of radiographic emphysema and airflow obstruction with lung cancer.

J. Leader, J. Siegfried, J. Weissfeld, 2008, American journal of respiratory and critical care medicine.

Metabolism of benzo(a)pyrene in monolayer cultures of human bronchial epithelial cells from a series of donors.

S. Nesnow, J. Siegfried, M. Mass, 1986, Cancer research.

Detection of Occult Lymph Node Metastases in Esophageal Cancer by Minimally Invasive Staging Combined with Molecular Diagnostic Techniques

P. Schauer, J. Luketich, J. Siegfried, 1998, JSLS : Journal of the Society of Laparoendoscopic Surgeons.

Detection of micrometastases in histologically negative lymph nodes in esophageal cancer.

P. Schauer, J. Luketich, J. Siegfried, 1998, The Annals of thoracic surgery.

Stimulatory effects of hepatocyte growth factor on normal and neoplastic human bronchial epithelial cells.

J. Siegfried, R. Zarnegar, P. Singh-Kaw, 1995, The American journal of physiology.

Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck.

D. Grignon, J. Siegfried, W. Sakr, 1996, Cancer research.

Response of primary human lung carcinomas to autocrine growth factors produced by a lung carcinoma cell line.

J. Siegfried, S. Owens, S. E. Owens, 1988, Cancer research.

Monolayer culture of human endometrium: Methods of culture and identification of cell types

J. Siegfried, D. Kaufman, V. Varma, 1982, In Vitro.

Genes for tumor markers are clustered with cellular proto-oncogenes on human chromosomes.

J. Siegfried, J. Hozier, M. Mass, 1987, Cancer letters.

Multianalyte profiling of serum cytokines for detection of pancreatic cancer.

D. Landsittel, J. Siegfried, A. Moser, 2005, Cancer biomarkers : section A of Disease markers.

Production of gastrin-releasing peptide by a non-small cell lung carcinoma cell line adapted to serum-free and growth factor-free conditions.

J. Siegfried, Y. H. Han, F. Cuttitta, 1994, The Journal of biological chemistry.

Comparison of anthracycline concentrations in S180 cell lines of varying sensitivity.

J. Siegfried, A. Sartorelli, T. Tritton, 1983, European journal of cancer & clinical oncology.

Transfection of a Rat Cytochrome P450b cDNA Into C3H10T1/2CL8 Mouse Embryo Fibroblasts

S. Nesnow, J. Siegfried, R. Langenbach, 1989, Molecular carcinogenesis.

Combined Inhibition of c-Src and Epidermal Growth Factor Receptor Abrogates Growth and Invasion of Head and Neck Squamous Cell Carcinoma

S. Choi, J. Siegfried, A. Egloff, 2008, Clinical Cancer Research.

Detection of human lung epithelial cell growth factors produced by a lung carcinoma cell line: use in culture of primary solid lung tumors.

J. Siegfried, 1987, Cancer research.

Evidence for autocrine actions of neuromedin B and gastrin-releasing peptide in non-small cell lung cancer.

J. Siegfried, J. D. Hunt, J. Hunt, 1999, Pulmonary pharmacology & therapeutics.

Lung cancer-derived bombesin-like peptides down-regulate the generation and function of human dendritic cells

J. Siegfried, V. Gerein, G. Shurin, 2003, Journal of Neuroimmunology.

Biology and chemoprevention of lung cancer.

J. Siegfried, 1998, Chest.

Nicotine signals through muscle-type and neuronal nicotinic acetylcholine receptors in both human bronchial epithelial cells and airway fibroblasts

J. Luketich, J. Siegfried, D. Carlisle, 2004, Respiratory research.

ASSOCIATION FOR ACADEMIC SURGERY Increased Levels of Tumor-Infiltrating Lymphocytes are Associated with Improved Recurrence-Free Survival in Stage 1A Non-Small-Cell Lung Cancer

J. Luketich, J. Siegfried, S. Yousem, 2011 .

Comparison of mutations in the p53 and K-ras genes in lung carcinomas from smoking and nonsmoking women.

J. Luketich, J. Siegfried, P. Keohavong, 1999, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Role of NQO1 polymorphisms as risk factors for squamous cell carcinoma of the head and neck.

J. Siegfried, J. Grandis, S. El-Sayed, 2005, Oral oncology.

Kinin B2 Receptor Mediates Induction of Cyclooxygenase-2 and Is Overexpressed in Head and Neck Squamous Cell Carcinomas

J. Siegfried, R. Seethala, J. Grandis, 2008, Molecular Cancer Research.

Kinin B 2 Receptor Mediates Induction of Cyclooxygenase-2 and Is Overexpressed in Head and Neck Squamous Cell Carcinomas

J. Siegfried, R. Seethala, J. Grandis, 2008 .

Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma.

J. Siegfried, J. Grandis, D. Chan, 2006, Cancer research.

Effects of bombesin and gastrin‐releasing peptide on human bronchial epithelial cells from a series of donors: Individual variation and modulation by bombesin analogs

J. Siegfried, Paul J. Guentert, Autumn L. Gaither, 1993, The Anatomical record.

Combined Inhibition of cSrc and Epidermal Growth Factor ReceptorAbrogates Growth and Invasion of Head and Neck Squamous Cell Carcinoma

S. Choi, J. Siegfried, A. Egloff, 2008 .

Expression of mRNA for three bombesin receptor subtypes in human bronchial epithelial cells.

J. Siegfried, R. Landreneau, J. D. Hunt, 1994, American journal of respiratory cell and molecular biology.

Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer.

Jian Yu, J. Siegfried, S. Dacic, 2008, Carcinogenesis.

Histochemical identification of cultured cells from human endometrium

J. Siegfried, K. Nelson, D. Kaufman, 2007, In Vitro.

Enhancement by TPA of phenotypes associated with transformation in carcinogen‐treated human cells: Evidence for a selective mechanism

J. Siegfried, David Kaufman, D. Kaufman, 1983, International journal of cancer.

A mitogenic peptide amide encoded within the E peptide domain of the insulin-like growth factor IB prohormone.

J. Siegfried, J. Mulshine, F. Cuttitta, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Hepatocyte growth factor promotes tumor growth in a novel in vivo model of human lung cancer.

J. Siegfried, J. Pilewski, T. S. Bumbalo, 2001, American journal of respiratory cell and molecular biology.

Phase I trial of carboplatin and etoposide in combination with panobinostat in patients with lung cancer.

M. Socinski, J. Siegfried, A. Argiris, 2013, Anticancer research.

Alpha-amidation of peptide hormones in lung cancer.

J. Siegfried, J. Mulshine, I. Avis, 1991, Cancer cells.

Validation of a blood protein signature for non-small cell lung cancer

Stephen A. Williams, Y. Miller, H. Pass, 2014, Clinical Proteomics.

Secretion of autocrine growth factors by cultured human lung tumors: Effects on neoplastic lung epithelial cells

J. Siegfried, S. Owens, S. Hansen, 1988 .

Meeting Report: Translational Advances in Cancer Prevention Agent Development Meeting

P. Brown, R. Glynn, M. You, 2021, Journal of cancer prevention.

Lung Adenocarcinoma Syndecan-2 Potentiates Cell Invasiveness.

J. Siegfried, S. Belinsky, K. Tsoyi, 2019, American journal of respiratory cell and molecular biology.

Morphology and growth potential of stromal cell cultures derived from human endometrium

J. Siegfried, D. Kaufman, V. Varma, 1982, In Vitro.

Targeting the ERβ/HER Oncogenic Network in KRAS Mutant Lung Cancer Modulates the Tumor Microenvironment and Is Synergistic with Sequential Immunotherapy

J. Siegfried, L. Stabile, A. Soloff, 2021, International journal of molecular sciences.

Comprehensive molecular profiling of lung adenocarcinoma

Steven J. M. Jones, Christopher A. Miller, Joshua M. Stuart, 2014, Nature.

The heterogeneity of LDH isoenzyme patterns of human uterine sarcomas and cultured sarcoma cell lines.

J. Siegfried, K. Nelson, D. Kaufman, 1984, The American journal of pathology.

Expression of PAM50 Genes in Lung Cancer: Evidence that Interactions between Hormone Receptors and HER2/HER3 Contribute to Poor Outcome12

J. Siegfried, M. Romkes, J. Weissfeld, 2015, Neoplasia.

Downregulation of Dkk3 activates β-catenin/TCF-4 signaling in lung cancer

Jian Yu, J. Siegfried, S. Dacic, 2008 .

Progress in Chemoprevention Drug Development: The Promise of Molecular Biomarkers for Prevention of Intraepithelial Neoplasia and Cancer—A Plan to Move Forward

G. Mills, S. Lam, M. Spitz, 2006, Clinical Cancer Research.

Comparison of p53 mutations between adenocarcinoma and squamous cell carcinoma of the lung: unique spectra involving G to A transitions and G to T transversions in both histologic types.

J. Luketich, J. Siegfried, P. Keohavong, 2003, Lung cancer.

Tumor Epidermal Growth Factor Receptor and EGFR PY1068 Are Independent Prognostic Indicators for Head and Neck Squamous Cell Carcinoma

G. Mills, J. Siegfried, A. Egloff, 2012, Clinical Cancer Research.

Molecular Analysis of Plasma DNA for the Early Detection of Lung Cancer by Quantitative Methylation-Specific PCR

W. Rom, J. Siegfried, J. Grandis, 2010, Clinical Cancer Research.

Clinical relevance of chromosome abnormalities in non-small cell lung cancer.

J. Siegfried, J. Testa, S. Litwin, 1998, Cancer genetics and cytogenetics.

Characterization of 9q;15q whole-arm translocation derivatives in non-small cell lung carcinomas by fluorescence in situ hybridization.

S. Jhanwar, J. Siegfried, J. Testa, 1993, Cancer genetics and cytogenetics.

Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients.

J. Luketich, J. Siegfried, Q. Lan, 2006, Neoplasia.

Comprehensive molecular profiling of lung adenocarcinoma

Steven J. M. Jones, Christopher A. Miller, Joshua M. Stuart, 2014, Nature.

ATM protein is deficient in over 40% of lung adenocarcinomas

J. Siegfried, T. Conrads, S. Dacic, 2016, Oncotarget.

15q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers.

C. Amos, F. Gilliland, J. Siegfried, 2015, Journal of the National Cancer Institute.

Trinucleotide repeat length variation in the human ribosomal protein L14 gene (RPL14): localization to 3p21.3 and loss of heterozygosity in lung and oral cancers.

M. Shriver, J. Siegfried, R. Ferrell, 1998, Mutation research.

Correlation of model chromosome number of cultured non-small cell lung carcinomas with DNA index of solid tumor tissue.

J. Siegfried, J. Testa, J. Resau, 1991, Cancer research.

Clinical Utility of Chromosomal Aneusomy in Individuals at High Risk of Lung Cancer

Y. Miller, J. Siegfried, W. Franklin, 2017, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Lung Cancer Risk Prediction Using Common SNPs Located in GWAS-Identified Susceptibility Regions

David O Wilson, Hui-Min Lin, Brenda F Kurland, 2015, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Genetic determinants for promoter hypermethylation in the lungs of smokers: a candidate gene-based study.

M. Thun, C. Amos, F. Gilliland, 2012, Cancer research.

Association of the EGFR intron 1 CA repeat length with lung cancer risk

J. Siegfried, M. Romkes, J. Weissfeld, 2007, Molecular carcinogenesis.

Mutation and Polymorphism in the EGFR-TK Domain Associated with Lung Cancer

J. Siegfried, M. Romkes, J. Grandis, 2006, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

The prognostic and predictive value of KRAS oncogene substitutions in lung adenocarcinoma

Simion I. Chiosea, M. Socinski, J. Siegfried, 2013, Cancer.

Multiple Cytokine and Growth Factor Serum Biomarkers Predict Therapeutic Response and Survival in Advanced-Stage Head and Neck Cancer Patients

J. Siegfried, J. Grandis, W. Bigbee, 2007, Clinical Cancer Research.

Fibulin-5 suppresses lung cancer invasion by inhibiting matrix metalloproteinase-7 expression.

Jian Yu, J. Siegfried, Lin Zhang, 2009, Cancer research.

Expression of mRNA for gastrin-releasing peptide receptor by human bronchial epithelial cells. Association with prolonged tobacco exposure and responsiveness to bombesin-like peptides.

J. Siegfried, J. Pilewski, J. D. Hunt, 1997, American journal of respiratory and critical care medicine.

Randomized phase II study of fulvestrant and erlotinib compared with erlotinib alone in patients with advanced or metastatic non-small cell lung cancer.

Patricia A. Young, R. Elashoff, J. Siegfried, 2018, Lung cancer.

Pilot study of gefitinib and fulvestrant in the treatment of post-menopausal women with advanced non-small cell lung cancer.

J. Siegfried, S. Dacic, J. Kolesar, 2009, Lung cancer.

Hormone replacement therapy and decreased lung cancer survival.

J. Siegfried, 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Combined targeting of the estrogen receptor and the epidermal growth factor receptor in non-small cell lung cancer shows enhanced antiproliferative effects.

J. Siegfried, J. Grandis, L. Stabile, 2005, Cancer research.

Human Non-Small Cell Lung Tumors and Cells Derived from Normal Lung Express Both Estrogen Receptor α and β and Show Biological Responses to Estrogen

J. Luketich, J. Siegfried, S. Finkelstein, 2002 .

Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokers

J. Luketich, J. Siegfried, J. Weissfeld, 2007, BMC Cancer.

Transgenic mice overexpressing hepatocyte growth factor in the airways show increased susceptibility to lung cancer.

J. Siegfried, S. Dacic, S. Land, 2005, Carcinogenesis.

HGF-independent Potentiation of EGFR Action by c-Met

A. Dulak, J. Siegfried, Cassandra Henry, 2011, Oncogene.

Novel targets for lung cancer therapy

J. Siegfried, L. Stabile, 2006 .

Alterations of human endometrial stromal cells produced by N-methyl-N'-nitro-N-nitrosoguanidine.

J. Siegfried, D. Kaufman, B. Dorman, 1983, Cancer research.

Targeting of Both the c-Met and EGFR Pathways Results in Additive Inhibition of Lung Tumorigenesis in Transgenic Mice

J. Siegfried, N. Kaminski, S. Land, 2010, Cancers.

Elevated hepatocyte growth factor level correlates with poor outcome in early-stage and late-stage adenocarcinoma of the lung.

J. Luketich, J. Siegfried, S. Land, 2004, Chest.

Endometrial stromal cells in culture: an attempt to understand the genesis and biologic activity of uterine sarcomas.

J. Siegfried, K. Nelson, D. Kaufman, 1986, Gynecologic oncology.

Status of Agents Targeting the HGF/c-Met Axis in Lung Cancer

J. Siegfried, M. Farooqui, O. Miranda, 2018, Cancers.

Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation.

G. Mills, J. Siegfried, J. Grandis, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Src Family Kinases Mediate Epidermal Growth Factor Receptor Ligand Cleavage, Proliferation, and Invasion of Head and Neck Cancer Cells

J. Siegfried, J. Grandis, S. Xi, 2004, Cancer Research.

SULF2 Methylation is Prognostic for Lung Cancer Survival and Increases Sensitivity to Topoisomerase-I inhibitors via Induction of ISG15

J. Siegfried, S. Dacic, S. Belinsky, 2011, Oncogene.

Induction of micronuclei in cultured human bronchial epithelial cells by direct-acting carcinogens.

J. Siegfried, P. Andrews, S. Owens, 1990, Toxicology in vitro : an international journal published in association with BIBRA.

The Pittsburgh Lung Screening Study (PLuSS): outcomes within 3 years of a first computed tomography scan.

David O Wilson, Carl R Fuhrman, J. Luketich, 2008, American journal of respiratory and critical care medicine.

Comprehensivegenomiccharacterization of squamous cell lung cancers

Joshua M. Stuart, Derek Y. Chiang, A. Sivachenko, 2012 .

Genetic instability of microsatellite sequences in many non-small cell lung carcinomas.

J. Siegfried, J. Hunt, D. Smith, 1994, Cancer research.

Non-small-cell lung cancer and breast carcinoma: chemotherapy and beyond.

J. Siegfried, A. Traynor, S. Dubey, 2006, The Lancet. Oncology.

Women and lung cancer: does oestrogen play a role?

J. Siegfried, J M Siegfried, 2001, The Lancet. Oncology.

Sex-specific expression of gastrin-releasing peptide receptor: relationship to smoking history and risk of lung cancer.

J. Luketich, J. Siegfried, C. Gubish, 2000, Journal of the National Cancer Institute.

Gene Promoter Hypermethylation Detected in Sputum Predicts FEV1 Decline and All‐Cause Mortality in Smokers

F. Gilliland, Jian-Min Yuan, J. Siegfried, 2018, American journal of respiratory and critical care medicine.

Matrix metalloproteinase-19 promotes metastatic behavior in vitro and is associated with increased mortality in non-small cell lung cancer.

Guoying Yu, A. Parwani, J. Siegfried, 2014, American journal of respiratory and critical care medicine.

Cancer Therapy : Preclinical cSrc Activation Mediates Erlotinib Resistance in Head and Neck Cancer by Stimulating c-Met

J. Siegfried, J. Grandis, M. Thomas, 2013 .

STAT3 Cyclic Decoy Demonstrates Robust Antitumor Effects in Non–Small Cell Lung Cancer

J. Siegfried, J. Grandis, Daniel E. Johnson, 2018, Molecular Cancer Therapeutics.

Strategies for identification of peptide growth factors.

J. Siegfried, Jill M. Siegfried, 1992, Pharmacology & therapeutics.

Pan-erbB inhibition potentiates BRAF inhibitors for melanoma treatment

J. Kirkwood, J. Ho, J. Siegfried, 2014, Melanoma research.

Inhibiting pathways predicted from a steroid hormone gene signature yields synergistic anti-tumor effects in non-small cell lung cancer.

J. Siegfried, M. Farooqui, Abdulaziz A. Almotlak, 2019, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Detection of Kras Mutations in Lung Carcinomas : Relationship to Prognosis 1

J. Siegfried, R. Weyant, R. Landreneau, 2008 .

Topographic analysis of K-ras mutations in histologically normal lung tissues and tumours of lung cancer patients

J. Luketich, J. Siegfried, P. Keohavong, 2001, British Journal of Cancer.

Dual Blockade of EGFR and c-Met Abrogates Redundant Signaling and Proliferation in Head and Neck Carcinoma Cells

J. Siegfried, J. Grandis, Hai-Yan Xu, 2011, Clinical Cancer Research.

J. Siegfried, S. Novello, J. Brahmer, 2018 .

The clinical significance of hepatocyte growth factor for non-small cell lung cancer.

J. Luketich, L. Weissfeld, J. Siegfried, 1998, The Annals of thoracic surgery.

Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma

J. Siegfried, C. Bakkenist, J. Beumer, 2015, BMC Cancer.

Estrogen receptor beta (ERβ) subtype-specific ligands increase transcription, p44/p42 mitogen activated protein kinase (MAPK) activation and growth in human non-small cell lung cancer cells

J. Siegfried, M. Nichols, P. Hershberger, 2009, The Journal of Steroid Biochemistry and Molecular Biology.

Prevention of tobacco carcinogen-induced lung cancer in female mice using antiestrogens.

J. Siegfried, S. Dacic, S. Land, 2012, Carcinogenesis.

Cells cultured from non-small cell lung carcinomas are representative of solid tumor tissue based on cytogenetic evidence

J. Siegfried, J. Testa, J. Resau, 1991 .

Flow cytometric analysis of human uterine sarcomas and cell lines.

J. Siegfried, K. Nelson, D. Kaufman, 1987, Cancer research.

Impact of tumor size on outcomes after anatomic lung resection for stage 1A non-small cell lung cancer based on the current staging system.

J. Luketich, J. Siegfried, R. Landreneau, 2012, The Journal of thoracic and cardiovascular surgery.

A prospective and retrospective analysis of smoking behavior changes in ever smokers with high risk for lung cancer from New Mexico and Pennsylvania.

E. Claus, V. Clark, F. Gilliland, 2016, International journal of molecular epidemiology and genetics.

Sex-specific association of sequence variants in CBS and MTRR with risk for promoter hypermethylation in the lung epithelium of smokers.

T. Byers, J. Siegfried, S. Leng, 2012, Carcinogenesis.

Gastrin-releasing peptide receptor expression in non-cancerous bronchial epithelia is associated with lung cancer: a case-control study

York E Miller, Yongli Shuai, Y. Miller, 2012, Respiratory Research.

c-Src Activation Mediates Erlotinib Resistance in Head and Neck Cancer by Stimulating c-Met

J. Siegfried, J. Grandis, S. Thomas, 2012, Clinical Cancer Research.

Gene methylation biomarkers in sputum as a classifier for lung cancer risk

F. Khuri, J. Siegfried, S. Ramalingam, 2017, Oncotarget.

Frequent Inactivation of RAMP2, EFEMP1 and Dutt1 in Lung Cancer by Promoter Hypermethylation

Jian Yu, J. Siegfried, S. Dacic, 2007, Clinical Cancer Research.

Estrogen receptor signaling in lung cancer.

J. Siegfried, P. Hershberger, L. Stabile, 2009, Seminars in oncology.

Effects of anthracyclines on oxygenated and hypoxic tumor cells.

J. Siegfried, A. Sartorelli, T. Tritton, 1983, Cancer research.

Cellular transport of anthracyclines by passive diffusion. Implications for drug resistance.

J. Siegfried, T. Burke, T. Tritton, 1985, Biochemical pharmacology.

Erlotinib, Erlotinib–Sulindac versus Placebo: A Randomized, Double-Blind, Placebo-Controlled Window Trial in Operable Head and Neck Cancer

Simion I. Chiosea, J. Siegfried, Lin Wang, 2014, Clinical Cancer Research.

Association of polymorphisms in the cyclin D1 and XPD genes and susceptibility to cancers of the upper aero‐digestive tract

J. Siegfried, M. Romkes, J. Grandis, 2005, Molecular carcinogenesis.

Combining the Multitargeted Tyrosine Kinase Inhibitor Vandetanib with the Antiestrogen Fulvestrant Enhances Its Antitumor Effect in Non-small Cell Lung Cancer

J. Siegfried, Cassandra Henry, L. Stabile, 2012, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Lung Endothelial MicroRNA‐1 Regulates Tumor Growth and Angiogenesis

M. Pisani, R. Herbst, J. Siegfried, 2017, American journal of respiratory and critical care medicine.

Prevention of Tobacco Carcinogen-Induced Lung Tumor Development by a Novel STAT3 Decoy Inhibitor

J. Siegfried, M. Farooqui, Abdulaziz A. Almotlak, 2020, Cancer Prevention Research.

Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis

A. Dulak, J. Siegfried, S. Dacic, 2008, Molecular Cancer Therapeutics.

Increased methylation of lung cancer-associated genes in sputum DNA of former smokers with chronic mucous hypersecretion

J. Siegfried, J. Weissfeld, S. Belinsky, 2014, Respiratory Research.

Association of the DNA repair gene XPD Asp312Asn polymorphism with p53 gene mutations in tobacco-related non-small cell lung cancer.

J. Luketich, J. Siegfried, M. Romkes, 2003, Carcinogenesis.

Lung cancer screening in high-risk populations.

J. Siegfried, 1999, Clinical lung cancer.

Myeloid STAT3 Promotes Lung Tumorigenesis by Transforming Tumor Immunosurveillance into Tumor-Promoting Inflammation

J. Siegfried, Lin-Feng Chen, G. Xiao, 2017, Cancer Immunology Research.

KRAS and TP53 mutations in bronchoscopy samples from former lung cancer patients

J. Luketich, J. Siegfried, S. Land, 2017, Molecular carcinogenesis.

Lung cancer serum biomarker discovery using glycoprotein capture and liquid chromatography mass spectrometry.

Brian L Hood, Thomas P Conrads, R. Day, 2010, Journal of proteome research.

Estrongenic steroid hormones in lung cancer.

J. Siegfried, L. Stabile, 2014, Seminars in oncology.

Anatomic segmentectomy for the solitary pulmonary nodule and early-stage lung cancer.

J. Luketich, J. Siegfried, R. Landreneau, 2012, The Annals of thoracic surgery.

Analysis of isoenzymes in normal and carcinogen-treated human endometrial stromal cells in culture.

J. Siegfried, K. Nelson, D. Kaufman, 1985, Carcinogenesis.

HGF and c-Met Participate in Paracrine Tumorigenic Pathways in Head and Neck Squamous Cell Cancer

J. Siegfried, A. Egloff, R. Seethala, 2009, Clinical Cancer Research.

Promotional effect of diethylstilbestrol on human endometrial stromal cells pretreated with a direct-acting carcinogen.

J. Siegfried, K. Nelson, D. Kaufman, 1984, Carcinogenesis.

Immunohistochemical Analysis of Phosphotyrosine Signal Transducer and Activator of Transcription 3 and Epidermal Growth Factor Receptor Autocrine Signaling Pathways in Head and Neck Cancers and Metastatic Lymph Nodes

J. Siegfried, R. Seethala, J. Grandis, 2008, Clinical Cancer Research.

Effect of phorbol esters on clonal cultures of human, hamster, and rat respiratory epithelial cells.

J. Siegfried, M. Mass, D. Beeman, 1987, Cancer research.

NF-κB1 p105 suppresses lung tumorigenesis through the Tpl2 kinase but independently of its NF-κB function

J. Siegfried, T. Burns, G. Xiao, 2015, Oncogene.

Cytotoxicity of chemical carcinogens towards human bronchial epithelial cells evaluated in a clonal assay.

S. Nesnow, J. Siegfried, 1984, Carcinogenesis.

Lung Cancer Serum Biomarker Discovery Using Label-Free Liquid Chromatography-Tandem Mass Spectrometry

R. Day, J. Siegfried, J. Weissfeld, 2011, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Early Detection of Head and Neck Cancer: Development of a Novel Screening Tool Using Multiplexed Immunobead-Based Biomarker Profiling

Faina Linkov, William Bigbee, Alex Lisovich, 2007, Cancer Epidemiology Biomarkers & Prevention.

Gene methylation biomarkers in sputum as a classifier for lung cancer risk

F. Khuri, J. Siegfried, S. Ramalingam, 2017, Oncotarget.

Early Changes in Pulmonary Gene Expression following Tobacco Exposure Shed Light on the Role of Estrogen Metabolism in Lung Carcinogenesis

J. Siegfried, 2010, Cancer Prevention Research.

Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer

Jill M. Siegfried, Doris R. Siwak, Gordon B. Mills, 2007, Molecular Cancer Therapeutics.

Sex and Gender Differences in Lung Cancer and Chronic Obstructive Lung Disease.

J. Siegfried, 2021, Endocrinology.

Genetic variability in DNA repair and cell cycle control pathway genes and risk of smoking‐related lung cancer

R. Day, J. Siegfried, M. Romkes, 2012, Molecular carcinogenesis.

A Multiplexed Serum Biomarker Immunoassay Panel Discriminates Clinical Lung Cancer Patients from High-Risk Individuals Found to be Cancer-Free by CT Screening

Vanathi Gopalakrishnan, David O Wilson, J. Siegfried, 2012, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Inherited Variation in the ATP-Binding Cassette Transporter ABCB1 and Survival after Chemotherapy for Stage III–IV Lung Cancer

M. Socinski, J. Siegfried, M. Romkes, 2014, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Evidence for the lack of relationship between inhibition of nucleic acid synthesis and cytotoxicity of adriamycin.

J. Siegfried, A. Sartorelli, T. Tritton, 1983, Cancer biochemistry biophysics.

Transfer and expression of the human interleukin-4 gene in carcinoma and stromal cell lines derived from lung cancer patients.

J. Siegfried, M. Lotze, R. Landreneau, 1993, Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy.

Elevated gastrin‐releasing peptide receptor mRNA expression in buccal mucosa: Association with head and neck squamous cell carcinoma

J. Siegfried, A. Egloff, J. Grandis, 2013, Head & neck.

Polymorphisms in DNA repair genes XPD and XRCC1 and p53 mutations in lung carcinomas of never‐smokers

J. Luketich, J. Siegfried, M. Romkes, 2006, Molecular carcinogenesis.

No association between the XPD 312, 751, or XRCC1 399 polymorphisms and K-ras gene mutation in smoking non-small-cell lung cancer.

J. Luketich, J. Siegfried, M. Romkes, 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Null Results in Brief No Association between the XPD 312 , 751 , or XRCC 1 399 Polymorphisms and Kras Gene Mutation in Smoking Non-Small-Cell Lung Cancer

J. Luketich, J. Siegfried, M. Romkes, 2004 .

Interim safety analysis of a phase II study of erlotinib (E) alone or combined with fulvestrant (F) in previously treated patients with advanced non-small cell lung cancer (NSCLC)

J. Siegfried, L. Goodglick, F. Kabbinavar, 2008 .

Combination therapy with gefitinib and fulvestrant (G/F) for women with non-small cell lung cancer (NSCLC)

J. Siegfried, J. Kolesar, J. Schiller, 2005 .

Combined chromosome microdissection and comparative genomic hybridization detect multiple sites of amplified DNA in a human lung carcinoma cell line

J. Siegfried, D. Bell, J. Testa, 1997, Genes, chromosomes & cancer.

For Peer Review Prevention of Tobacco Carcinogen-Induced Lung Cancer in Female Mice Using Anti-Estrogens

J. Siegfried, P. Keohavong, L. Stabile, 2012 .

Characterization of a pure heterologous sarcoma of the uterus: rhabdomyosarcoma of the corpus.

J. Siegfried, K. Nelson, D. Kaufman, 1983, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

Flow Cytometric Analysis of Human Uterine Sarcomas and Cell Lines1

J. Siegfried, K. Nelson, D. Kaufman, 2006 .

Cytogenetic abnormalities in non‐small cell lung carcinoma: Similarity of findings in conventional and feeder cell layer cultures

J. Siegfried, J. Testa, S. Keller, 1993, Genes, chromosomes & cancer.

Chromosome alterations in 21 non‐small cell lung carcinomas

J. Siegfried, J. Testa, J. Resau, 1990, Genes, chromosomes & cancer.

Inhibition of human non-small cell lung tumors by a c-Met antisense/U6 expression plasmid strategy

J. Siegfried, Leaf Huang, L. Huang, 2004, Gene Therapy.

Serum biomarker profiles as diagnostic tools in lung cancer.

Christopher J Langmead, David O Wilson, C. Langmead, 2011, Cancer biomarkers : section A of Disease markers.

Validation of a blood protein signature for non-small cell lung cancer

Stephen A. Williams, Y. Miller, H. Pass, 2014, Clinical Proteomics.

Early events in the neoplastic transformation of respiratory epithelium.

J. Siegfried, M. Birrer, É. Szabó, 1992, Journal of the National Cancer Institute. Monographs.

Correction: HGF and c-Met Participate in Paracrine Tumorigenic Pathways in Head and Neck Squamous Cell Cancer

J. Siegfried, A. Egloff, R. Seethala, 2010, Clinical Cancer Research.

ENHANCEMENT BY TPA OF PHENOTYPES ASSOCIATED WITH EVIDENCE FOR A SELECTIVE MECHANISM TRANSFORMATION IN CARCINOGEN-TREATED HUMAN CELLS:

J. Siegfried, D. Kaufman, 2006 .

Illustration of the obstacles in computerized lung segmentation using examples.

Carl R. Fuhrman, Jill M. Siegfried, Jiantao Pu, 2012, Medical physics.

Comprehensive genomic characterization of squamous cell lung cancers

Joshua M. Stuart, Brian D. O’Connor, Charles J. Vaske, 2012, Nature.

Increased levels of tumor-infiltrating lymphocytes are associated with improved recurrence-free survival in stage 1A non-small-cell lung cancer.

J. Luketich, J. Siegfried, S. Yousem, 2011, The Journal of surgical research.

Estrogen receptor signaling in lung cancer.

J. Siegfried, P. Hershberger, L. Stabile, 2009, Seminars in oncology.

Transfection of cytochrome P450 cDNAs into mammalian cells used in mutation and transformation assays.

S. Nesnow, J. Siegfried, P. Smith, 1990, Progress in clinical and biological research.

Combining the Multitargeted Tyrosine Kinase Inhibitor Vandetanib with the Antiestrogen Fulvestrant Enhances Its Antitumor Effect in Non-small Cell Lung Cancer

J. Siegfried, Cassandra Henry, L. Stabile, 2012, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Carcinomas with DNA Index of Solid Tumor Tissue1

Joseph, J. Siegfried, J. Resau, 2006 .

Automated Lobe-Based Airway Labeling

J. Pu, S. Gu, David Wilson, 2012, Int. J. Biomed. Imaging.

Anatomic Lung Resection for Clinical Stage I Non-small Cell Lung Cancer (NSCLC): Equivalent Outcomes Following Anatomic Segmentectomy and Lobectomy

J. Luketich, J. Siegfried, R. Landreneau, 2010 .

Lung cancer serum biomarker discovery using glycoprotein capture and liquid chromatography mass spectrometry.

R. Day, J. Siegfried, J. Weissfeld, 2010, Journal of proteome research.

Abstract 4664: Result of TORI L-03, a randomized, multicenter phase II clinical trial of erlotinib (E) or E + fulvestrant (F) in previously treated advanced non-small cell lung cancer (NSCLC).

R. Elashoff, J. Siegfried, S. Dacic, 2013 .

Combined Analysis of Estrogen Receptor β-1 and Progesterone Receptor Expression Identifies Lung Cancer Patients with Poor Outcome

R. Dhir, J. Siegfried, J. Grandis, 2010, Clinical Cancer Research.

Prevention of tobacco carcinogen-induced lung cancer in female mice using antiestrogens.

J. Siegfried, S. Dacic, S. Land, 2012, Carcinogenesis.

RET Rearrangements in Lung Adenocarcinoma and Radiation

M. Socinski, J. Siegfried, S. Dacic, 2014, Journal of Thoracic Oncology.

Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis

A. Dulak, J. Siegfried, S. Dacic, 2008, Molecular Cancer Therapeutics.