R. Okayasu

发表

Application of monochromatic keV X-ray source to X-ray drug delivery system

M. Uesaka, Hiroki Taguchi, Azusa Mori, 2009 .

Resistance of Bacillus subtilis Spore DNA to Lethal Ionizing Radiation Damage Relies Primarily on Spore Core Components and DNA Repair, with Minor Effects of Oxygen Radical Detoxification

G. Reitz, W. Nicholson, R. Okayasu, 2013, Applied and Environmental Microbiology.

Astrobiological aspects of the mutagenesis of cosmic radiation on bacterial spores.

G. Reitz, G. Horneck, W. Nicholson, 2010, Astrobiology.

Roles of the Major, Small, Acid-Soluble Spore Proteins and Spore-Specific and Universal DNA Repair Mechanisms in Resistance of Bacillus subtilis Spores to Ionizing Radiation from X Rays and High-Energy Charged-Particle Bombardment

G. Reitz, G. Horneck, P. Rettberg, 2007, Journal of bacteriology.

Strategies to Enhance Radiosensitivity to Heavy Ion Radiation Therapy.

R. Okayasu, Younghyun Lee, 2018, International journal of particle therapy.

p53 independent radio-sensitization of human lymphoblastoid cell lines by Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin.

Takamitsu A Kato, R. Okayasu, N. Kubota, 2009, Oncology Report.

Effects of hyperthermia on the repair of radiation-induced DNA single- and double-strand breaks in DNA double-strand break repair-deficient and repair-proficient cell lines.

R. Okayasu, G. Iliakis, R. Seaner, 1990, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

The complexity of DNA double strand breaks is a critical factor enhancing end-resection.

P. Jeggo, R. Okayasu, A. Fujimori, 2013, DNA repair.

Wortmannin inhibits repair of DNA double-strand breaks in irradiated normal human cells.

R. Okayasu, R. Ullrich, K. Suetomi, 1998, Radiation research.

Radiosensitization of normal human cells by LY294002: cell killing and the rejoining of DNA and interphase chromosome breaks.

R. Okayasu, J. Bedford, K. Takakura, 2003, Journal of radiation research.

Visualisation of γH2AX Foci Caused by Heavy Ion Particle Traversal; Distinction between Core Track versus Non-Track Damage

A. Shibata, P. Jeggo, R. Okayasu, 2013, PloS one.

125IdUrd-induced chromosome fragments, assayed by premature chromosome condensation, and DNA double-strand breaks have similar repair kinetics in G1-phase CHO-cells.

R. Okayasu, G. Iliakis, G. Pantelias, 1987, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Mechanism of radiosensitization by halogenated pyrimidines: effect of BrdU on radiation induction of DNA and chromosome damage and its correlation with cell killing.

R. Okayasu, G. Iliakis, G. Pantelias, 1989, Radiation research.

Parg deficiency confers radio-sensitization through enhanced cell death in mouse ES cells exposed to various forms of ionizing radiation.

R. Okayasu, M. Masutani, K. Sasai, 2013, Biochemical and biophysical research communications.

Chemopreventive agent sulforaphane enhances radiosensitivity in human tumor cells

R. Okayasu, N. Kubota, A. Fujimori, 2009, International journal of cancer.

Regulation of ATM in DNA double strand break repair accounts for the radiosensitivity in human cells exposed to high linear energy transfer ionizing radiation.

R. Okayasu, S. Fan, J. Tong, 2009, Mutation research.

High LET heavy ion radiation induces lower numbers of initial chromosome breaks with minimal repair than low LET radiation in normal human cells.

R. Okayasu, Dong Yu, N. Matsufuji, 2008, Mutation research.

Lethal DNA Lesions Caused by Direct and Indirect Actions of X rays are Repaired via Different DSB Repair Pathways under Aerobic and Anoxic Conditions

R. Okayasu, M. Noguchi, Y. Matsumoto, 2021, Radiation Research.

OH Radicals from the Indirect Actions of X-Rays Induce Cell Lethality and Mediate the Majority of the Oxygen Enhancement Effect

R. Okayasu, M. Noguchi, Y. Matsumoto, 2013, Radiation research.

Induction of DNA DSB and its rejoining in clamped and non-clamped tumours after exposure to carbon ion beams in comparison to X rays.

R. Okayasu, M. Noguchi, Y. Matsumoto, 2011, Radiation protection dosimetry.

Radioprotection by DMSO in nitrogen-saturated mammalian cells exposed to helium ion beams

R. Okayasu, M. Noguchi, Y. Matsumoto, 2009 .

Radiosensitivity throughout the cell cycle and repair of potentially lethal damage and DNA double-strand breaks in an X-ray-sensitive CHO mutant.

R. Okayasu, G. Iliakis, 1990, International journal of radiation biology.

The level of induced DNA double-strand breaks does not correlate with cell killing in X-irradiated mitotic and G1-phase CHO cells.

R. Okayasu, G. Iliakis, 1988, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Elevated breast cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc (DNA-dependent protein kinase catalytic subunit) gene.

R. Okayasu, R. Ullrich, Y. Yu, 2001, Cancer research.

Radiosensitization effect of poly(ADP‐ribose) polymerase inhibition in cells exposed to low and high liner energy transfer radiation

R. Okayasu, M. Masutani, K. Sasai, 2012, Cancer science.

ASPM influences DNA double-strand break repair and represents a potential target for radiotherapy

P. Jeggo, Takamitsu A Kato, R. Okayasu, 2011, International journal of radiation biology.

Advances in Brief Mitosis-promoting Factor Activity of Inducer Mitotic Cells May Affect Radiation Yield of Interphase Chromosome Breaks in the Premature Chromosome Condensation Assay 1

R. Okayasu, G. Iliakis, N. Cheong, 2007 .

Mitosis-promoting factor activity of inducer mitotic cells may affect radiation yield of interphase chromosome breaks in the premature chromosome condensation assay.

R. Okayasu, G. Iliakis, X. Cheng, 1993, Cancer research.

Inhibition of DNA-double strand break repair by antimony compounds.

R. Okayasu, J. Bedford, H. Utsumi, 2002, Toxicology.

Comparison of the bromodeoxyuridine-mediated sensitization effects between low-LET and high-LET ionizing radiation on DNA double-strand breaks.

Takamitsu A Kato, R. Okayasu, K. Miyagawa, 2013, Oncology reports.

In vitro characterization of cells derived from chordoma cell line U-CH1 following treatment with X-rays, heavy ions and chemotherapeutic drugs

M. Uesaka, Takamitsu A Kato, R. Okayasu, 2011, Radiation oncology.

Facilitated detection of chromosome break and repair at low levels of ionizing radiation by addition of wortmannin to G1-type PCC fusion incubation.

R. Okayasu, Maki Okada, Shiori Saito, 2004, Mutation research.

Caffeine Sensitizes Nondividing Human Fibroblasts to X Rays by Inducing a High Frequency of Misrepair

R. Okayasu, T. Kawata, F. Cucinotta, 2005, Radiation research.

A deficiency in DNA repair and DNA-PKcs expression in the radiosensitive BALB/c mouse.

R. Okayasu, R. Ullrich, J. Bedford, 2000, Cancer research.

Measurement of DNA Double Strand Breaks in Mammalian Cells: Comparison Between Pulsed Field Gel Electrophoresis and Non-Unwinding Filter Elution

R. Okayasu, G. Iliakis, G. Pantelias, 1991 .

Linear DNA elution dose response curves obtained in CHO cells with non-unwinding filter elution after appropriate selection of the lysis conditions.

R. Okayasu, G. Iliakis, 1989, International journal of radiation biology.

Defective repair of DNA double-strand breaks and chromosome damage in fibroblasts from a radiosensitive leukemia patient.

R. Okayasu, A. Begg, C. Badie, 1995, Cancer research.

Induction by H2O2 of DNA and interphase chromosome damage in plateau-phase Chinese hamster ovary cells.

R. Okayasu, G. Iliakis, G. Pantelias, 1992, Radiation research.

Variation through the cell cycle in the dose-response of DNA neutral filter elution in X-irradiated synchronous CHO-cells.

R. Okayasu, G. Iliakis, D. Bloecher, 1988, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Nontoxic concentration of DNA‐PK inhibitor NU7441 radio‐sensitizes lung tumor cells with little effect on double strand break repair

M. Uesaka, R. Okayasu, Cuihua Liu, 2016, Cancer science.

Radio-sensitivity of the cells from amyotrophic lateral sclerosis model mice transfected with human mutant SOD1.

R. Okayasu, H. Kusaka, Hidefumi Ito, 2005, Journal of radiation research.

G1 Premature Chromosome Condensation (PCC) Assay.

R. Okayasu, Cuihua Liu, 2019, Methods in molecular biology.

Radiosensitization by PARP inhibition to proton beam irradiation in cancer cells.

R. Okayasu, M. Masutani, S. Saito, 2016, Biochemical and biophysical research communications.

Asbestos and DNA double strand breaks.

R. Okayasu, R. Ullrich, T. Hei, 1999, Cancer research.

ATM-dependent hyper-radiosensitivity in mammalian cells irradiated by heavy ions.

R. Okayasu, S. Fan, Jianping Cao, 2009, International journal of radiation oncology, biology, physics.

The Influence of Mutation Induction in Normal Human Fibroblasts Irradiated with X Rays and Iron Ions

R. Okayasu, M. Suzuki, C. Tsuruoka, 2009 .

Evaluation of SCCVII tumor cell survival in clamped and non-clamped solid tumors exposed to carbon-ion beams in comparison to X-rays.

R. Okayasu, M. Noguchi, Y. Matsumoto, 2013, Mutation research.

Carbon ion beam is more effective to induce cell death in sphere-type A172 human glioblastoma cells compared with X-rays

R. Okayasu, A. Fujimori, Hirokazu Hirakawa, 2014, International journal of radiation biology.

Evidence that the product of the xrs gene is predominantly involved in the repair of a subset of radiation-induced interphase chromosome breaks rejoining with fast kinetics.

R. Okayasu, G. Iliakis, 1994, Radiation research.

Ionizing radiation induces two forms of interphase chromosome breaks in Chinese hamster ovary cells that rejoin with different kinetics and show different sensitivity to treatment in hypertonic medium or beta-araA.

R. Okayasu, G. Iliakis, 1993, Radiation research.

Single extreme low dose/low dose rate irradiation causes alteration in lifespan and genome instability in primary human cells

H. Kitamura, M. Okada, R. Okayasu, 2007, British Journal of Cancer.

Signatures of DNA double strand breaks produced in irradiated G1 and G2 cells persist into mitosis

Takamitsu A Kato, R. Okayasu, J. Bedford, 2009, Journal of cellular physiology.

Comparison of the induction and disappearance of DNA double strand breaks and gamma-H2AX foci after irradiation of chromosomes in G1-phase or in condensed metaphase cells.

Takamitsu A Kato, R. Okayasu, J. Bedford, 2008, Mutation research.

Novel characteristics of CtIP at damage-induced foci following the initiation of DNA end resection.

M. Uesaka, R. Okayasu, A. Fujimori, 2015, Mutation research.

Enhancement of chromosomal aberrations in tumor cells with a non-labeled Cu-PTSM and irradiation with Cu K-shell monochromatic X rays.

Y. Fujibayashi, R. Okayasu, K. Takakura, 2006, Radiation protection dosimetry.

Repair of DNA Damage Induced by Accelerated Heavy Ions in Mammalian Cells Proficient and Deficient in the Non-homologous End-Joining Pathway

R. Okayasu, M. Noguchi, A. Okabe, 2006, Radiation research.

Extremely low dose ionizing radiation up-regulates CXC chemokines in normal human fibroblasts.

R. Okayasu, A. Fujimori, S. Yoshida, 2005, Cancer research.

Benzyl isothiocyanate sensitizes human pancreatic cancer cells to radiation by inducing apoptosis.

R. Okayasu, K. Ohnishi, N. Kubota, 2011, International journal of molecular medicine.

Cytotoxicity of cigarette smoke condensate is not due to DNA double strand breaks: Comparative studies using radiosensitive mutant and wild-type CHO cells

Takamitsu A Kato, R. Okayasu, J. Bedford, 2007, International journal of radiation biology.

Chromosome aberrations in normal human fibroblasts analyzed in G0/G1 and G2/M phases after exposure in G0 to radiation with different linear energy transfer (LET).

R. Okayasu, Guangming Zhou, T. Kawata, 2013, Mutation research.

Low- and High-LET Ionizing Radiation Induces Delayed Homologous Recombination that Persists for Two Weeks before Resolving

N. Sharma, R. Okayasu, J. Nickoloff, 2017, Radiation Research.

Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation.

H. Liber, R. Okayasu, J. Bedford, 2002, Cancer research.

Selective Enhancing Effect of Early Mitotic Inhibitor 1 (Emi1) Depletion on the Sensitivity of Doxorubicin or X-ray Treatment in Human Cancer Cells*

R. Okayasu, H. Kawai, N. Ishimaru, 2013, The Journal of Biological Chemistry.

The complexity of DNA double strand break is a crucial factor for activating ATR signaling pathway for G2/M checkpoint regulation regardless of ATM function.

R. Okayasu, Y. Matsumoto, M. Miura, 2015, DNA repair.

Recent advances in the biology of heavy-ion cancer therapy.

Takamitsu A Kato, R. Okayasu, T. Teshima, 2010, Journal of radiation research.

Dose-rate effect was observed in T98G glioma cells following BNCT.

R. Okayasu, K. Ono, Y. Kubota, 2014, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

P33 15 TP – COMPARISON BETWEEN DNA DOUBLE STRAND BREAK REJOINING AND REJOINING OF CHROMATIN BREAKS IN IRRADIATED PLATEAU PHASE CHO CELLS

R. Okayasu, G. Iliakis, 1991 .

Pre-Exposure to Ionizing Radiation Stimulates DNA Double Strand Break End Resection, Promoting the Use of Homologous Recombination Repair

A. Shibata, R. Okayasu, T. Nakano, 2015, PloS one.

The Difference in LET and Ion Species Dependence for Induction of Initially Measured and Non-rejoined Chromatin Breaks in Normal Human Fibroblasts

M. Hande, R. Okayasu, C. Tsuruoka, 2008, Radiation research.

Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans.

Takamitsu A Kato, R. Okayasu, H. Ogi, 2008, Biochemical and biophysical research communications.

Radiation-Induced Delayed Genome Instability and Hypermutation in Mammalian Cells

R. Okayasu, J. Nickoloff, A. Fujimori, 2013 .

Effects of carbon ion beam on putative colon cancer stem cells and its comparison with X-rays.

R. Okayasu, M. Akashi, H. Tsujii, 2011, Cancer research.

Ascorbic acid gives different protective effects in human cells exposed to X-rays and heavy ions.

Takamitsu A Kato, R. Okayasu, N. Kubota, 2010, Mutation research.

Comparative studies on repair inhibition by araA, araC and aphidicolin of radiation induced DNA and chromosome damage in rodent cells: comparison with fixation of PLD.

R. Okayasu, G. Iliakis, G. Pantelias, 1989, International journal of radiation oncology, biology, physics.

Repair of DNA damage induced by accelerated heavy ions—A mini review

R. Okayasu, 2012, International journal of cancer.

Metabolism and the paradoxical effects of arsenic: carcinogenesis and anticancer.

R. Okayasu, M. Akashi, Yayoi Kobayashi, 2008, Current medicinal chemistry.

Biological effects of naturally occurring and man-made fibres: in vitro cytotoxicity and mutagenesis in mammalian cells

R. Okayasu, T. Hei, L. Wu, 1999, British Journal of Cancer.

Radiosensitive xrs-5 and parental CHO cells show identical DNA neutral filter elution dose-response: implications for a relationship between cell radiosensitivity and induction of DNA double-strand breaks.

R. Okayasu, G. Iliakis, R. Seaner, 1988, International journal of radiation biology.

Technical note: comparison of yields and repair kinetics of interphase chromosome breaks visualized by Sendai-virus or PEG-mediated cell fusion in irradiated CHO cells.

R. Okayasu, G. Iliakis, N. Cheong, 1993, International journal of radiation biology.

Mitotic metaphase cells from different cell lines cause different levels of expression of the α-form of interphase chromosome breaks irradiated CHO cels

R. Okayasu, G. Iliakis, 1994 .

Hypertonic treatment during premature chromosome condensation allows visualization of interphase chromosome breaks repaired with fast kinetics in irradiated CHO cells.

R. Okayasu, G. Iliakis, Y. Wang, 1993, Radiation research.

Increased frequency of formation of interphase ring-chromosomes in radiosensitive irs-1 cells exposed to X-rays.

R. Okayasu, G. Iliakis, G. Pantelias, 1993, Mutation research.

DNA topoisomerase inhibitor, etoposide, enhances GC‐box‐dependent promoter activity via Sp1 phosphorylation

R. Okayasu, H. Izumi, T. Torigoe, 2007, Cancer science.

The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining.

R. Okayasu, J. Nickoloff, A. Fujimori, 2016, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

TAS-116, a Novel Hsp90 Inhibitor, Selectively Enhances Radiosensitivity of Human Cancer Cells to X-rays and Carbon Ion Radiation

R. Okayasu, J. Nickoloff, A. Fujimori, 2016, Molecular Cancer Therapeutics.

VE-821, an ATR inhibitor, causes radiosensitization in human tumor cells irradiated with high LET radiation

M. Uesaka, R. Okayasu, A. Fujimori, 2015, Radiation Oncology.

Heterochromatin Domain Number Correlates with X-Ray and Carbon-Ion Radiation Resistance in Cancer Cells

R. Okayasu, T. Shimokawa, Katsutoshi Sato, 2014, Radiation research.

In vitro rejoining of double-strand breaks in cellular DNA by factors present in extracts of HeLa cells.

R. Okayasu, G. Iliakis, N. Cheong, 1996, International journal of radiation biology.

Arsenic accumulation, elimination, and interaction with copper, zinc and manganese in liver and kidney of rats.

R. Okayasu, X. Cui, 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation

N. Sharma, M. Durante, A. Jimeno, 2015, Front. Oncol..

DNA double-strand break induction in Ku80-deficient CHO cells following Boron Neutron Capture Reaction

R. Okayasu, K. Ono, Minoru Suzuki, 2011, Radiation oncology.

Influence of track directions on the biological consequences in cells irradiated with high LET heavy ions

Takamitsu A Kato, R. Okayasu, A. Fujimori, 2013, International journal of radiation biology.

Rejoining kinetics of G1-PCC breaks induced by different heavy-ion beams with a similar LET value.

R. Okayasu, C. Tsuruoka, K. Anzai, 2010, Mutation research.

Role of the Nfo and ExoA Apurinic/Apyrimidinic Endonucleases in Radiation Resistance and Radiation-Induced Mutagenesis of Bacillus subtilis Spores

G. Reitz, W. Nicholson, R. Okayasu, 2011, Journal of bacteriology.

Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites

P. Jeggo, A. Ui, Takamitsu A Kato, 2018, PLoS genetics.