Jiyoun Lee

发表

Target deconvolution techniques in modern phenotypic profiling.

M. Bogyo, Jiyoun Lee, 2013, Current opinion in chemical biology.

Discovery of an Orally Bioavailable Benzofuran Analogue That Serves as a β-Amyloid Aggregation Inhibitor for the Potential Treatment of Alzheimer's Disease.

Jiyoun Lee, D. Jo, H. Hong, 2018, Journal of medicinal chemistry.

Synthesis and evaluation of oxime derivatives as modulators for amyloid beta-induced mitochondrial dysfunction.

Jae Kyun Lee, J. Baik, Jiyoun Lee, 2013, European journal of medicinal chemistry.

Antihyperlipidemic Effect of Ginsenoside Rg1 in Type 2 Diabetic Mice

Jiyoun Lee, M. Jung, J. Yeo, 2011 .

cAMP-response element binding protein (CREB) positively regulates mouse adiponectin gene expression in 3T3-L1 adipocytes.

Jiyoun Lee, M. Jung, J. Yeo, 2010, Biochemical and biophysical research communications.

6-Phenoxy-2-phenylbenzoxazoles, novel inhibitors of receptor for advanced glycation end products (RAGE).

Jiyoun Lee, Y. Suh, H. Hong, 2015, Bioorganic & medicinal chemistry.

Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against Aβ-induced neurotoxicity.

Ashwini M. Londhe, Seo Yun Jung, Ki Duk Park, 2017, European journal of medicinal chemistry.

Activity-based probes for the high temperature requirement A serine proteases.

Jiyoun Lee, Jiwon Seo, Ho Yeon Nam, 2020, ACS chemical biology.

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase

Sarah E. Ewald, M. Bogyo, Jiyoun Lee, 2011, The Journal of experimental medicine.

Discovery of a Small Molecule that Enhances Astrocytogenesis by Activation of STAT3, SMAD1/5/8, and ERK1/2 via Induction of Cytokines in Neural Stem Cells.

Jiyoun Lee, Hyun-Jung Kim, S. Kong, 2016, ACS chemical neuroscience.

Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain.

M. Bogyo, Jiyoun Lee, 2010, ACS chemical biology.

Synthesis and biological evaluation of 3-(2-aminoethyl) uracil derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists.

Jiyoun Lee, So young Lee, Jihyae Ann, 2018, European journal of medicinal chemistry.

Effect of side chain hydrophobicity and cationic charge on antimicrobial activity and cytotoxicity of helical peptoids.

Jiyoun Lee, A. Barron, Jiwon Seo, 2018, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of 2-(3-arylureido)pyridines and 2-(3-arylureido)pyrazines as potential modulators of Aβ-induced mitochondrial dysfunction in Alzheimer's disease.

Jiyoun Lee, A. Pae, Jung-Eun Park, 2018, European journal of medicinal chemistry.

Synthesis and evaluation of new pyridyl/pyrazinyl thiourea derivatives: Neuroprotection against amyloid-β-induced toxicity.

Jiyoun Lee, A. Pae, Jung-Eun Park, 2017, European journal of medicinal chemistry.

Discovery of 2-aryloxy-4-amino-quinazoline derivatives as novel protease-activated receptor 2 (PAR2) antagonists.

Ki Duk Park, Jiyoun Lee, A. Pae, 2015, Bioorganic & medicinal chemistry.

Recent Advances in Organelle-Targeted Fluorescent Probes

Jiyoun Lee, Na-Eun Choi, Ji‐Yu Lee, 2021, Molecules.

Discovery of Conformationally Restricted Human Glutaminyl Cyclase Inhibitors as Potent Anti-Alzheimer's Agents by Structure-Based Design.

S. J. Y. Macalino, M. Cui, Sun Choi, 2019, Journal of medicinal chemistry.

Potent human glutaminyl cyclase inhibitors as potential anti-Alzheimer's agents: Structure-activity relationship study of Arg-mimetic region.

M. Cui, Sun Choi, Jiyoun Lee, 2018, Bioorganic & medicinal chemistry.

Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design.

Jiyoun Lee, Heejin Ha, Jihyae Ann, 2021, European journal of medicinal chemistry.

Novel quinazoline-urea analogues as modulators for Aβ-induced mitochondrial dysfunction: design, synthesis, and molecular docking study.

Jiyoun Lee, A. Pae, E. Roh, 2014, European journal of medicinal chemistry.

Discovery and biological evaluation of tetrahydrothieno[2,3-c]pyridine derivatives as selective metabotropic glutamate receptor 1 antagonists for the potential treatment of neuropathic pain.

Jiyoun Lee, Y. Cho, A. Pae, 2015, European journal of medicinal chemistry.

Analysis of structure-activity relationships with the N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea template for vanilloid receptor 1 antagonism.

Jiyoun Lee, S. Y. Kim, Jeewoo Lee, 2004, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of aryloxazole derivatives as antimitotic and vascular-disrupting agents for cancer therapy.

Jiyoun Lee, H. Choo, A. Pae, 2013, Journal of medicinal chemistry.

N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor.

Ji-Min Kim, Attila Toth, Jiyoun Lee, 2003, Journal of medicinal chemistry.

Design, synthesis, biological evaluation and molecular modelling of 2‐(2‐aryloxyphenyl)‐1,4‐dihydroisoquinolin‐3(2H)‐ones: A novel class of TSPO ligands modulating amyloid‐&bgr;‐induced mPTP opening

Ki Duk Park, Jiyoun Lee, Bongjin Moon, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Analysis of structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]-thiourea analogues as TRPV1 antagonists.

Vladimir A. Pavlyukovets, Jiyoun Lee, S. Y. Kim, 2005, Bioorganic & medicinal chemistry letters.

The translocator protein ligands as mitochondrial functional modulators for the potential anti-Alzheimer agents

Ashwini M. Londhe, Jiyoun Lee, M. Morshed, 2021, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and biological evaluation of aryl isoxazole derivatives as metabotropic glutamate receptor 1 antagonists: a potential treatment for neuropathic pain.

Jiyoun Lee, Y. Cho, H. Koh, 2015, Bioorganic & medicinal chemistry letters.

Aminopropyl carbazole analogues as potent enhancers of neurogenesis.

Jiyoun Lee, Jeewoo Lee, Hyun-Jung Kim, 2013, Bioorganic & medicinal chemistry.

Functional imaging of legumain in cancer using a new quenched activity-based probe.

M. Bogyo, Jiyoun Lee, M. Bachmann, 2013, Journal of the American Chemical Society.

A Lignin Molecular Brace Controls Precision Processing of Cell Walls Critical for Surface Integrity in Arabidopsis

Jiyoun Lee, J. Kwak, H. Cho, 2018, Cell.

Mitochondrial drug targets in neurodegenerative diseases.

Jiyoun Lee, 2016, Bioorganic & medicinal chemistry letters.

Discovery of an Orally Bioavailable Gonadotropin-Releasing Hormone Receptor Antagonist.

Jiyoun Lee, So young Lee, Jihyae Ann, 2016, Journal of medicinal chemistry.

Mitochondrial dysfunction and Alzheimer’s disease: prospects for therapeutic intervention

Jiyoun Lee, A. Pae, J. W. Lim, 2019, BMB reports.

Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Aβ-induced mitochondrial dysfunction

Ae Nim Pae, Jae Yeol Lee, Sang Min Lim, 2017, Journal of Computer-Aided Molecular Design.

Pyrazinyl ureas revisited: 1-(3-(Benzyloxy)pyrazin-2-yl)-3-(3,4-dichlorophenyl)urea, a new blocker of Aβ-induced mPTP opening for Alzheimer's disease.

Jiyoun Lee, A. Pae, Jung-Eun Park, 2018, European journal of medicinal chemistry.

The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages

Jiyoun Lee, Sehyun Chae, JaeHyung Koo, 2021, Proceedings of the National Academy of Sciences.

Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate

T. Meade, Jiyoun Lee, Lisa M Manus, 2009, Proceedings of the National Academy of Sciences.

The selective A3AR antagonist LJ-1888 ameliorates UUO-induced tubulointerstitial fibrosis.

Jiyoun Lee, L. Jeong, H. Ha, 2013, The American journal of pathology.

Structure-activity relationship of leucyladenylate sulfamate analogues as leucyl-tRNA synthetase (LRS)-targeting inhibitors of Mammalian target of rapamycin complex 1 (mTORC1).

Jiyoun Lee, Changhoon Kim, Woong Sub Byun, 2019, Bioorganic & medicinal chemistry.

Discovery of novel leucyladenylate sulfamate surrogates as leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors.

Won Kyung Kim, Jiyoun Lee, Jihyae Ann, 2018, Bioorganic & medicinal chemistry.

Discovery of simplified leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors.

Won Kyung Kim, Sunghoon Kim, Jiyoun Lee, 2016, Bioorganic & medicinal chemistry.

Discovery of (S)-4-isobutyloxazolidin-2-one as a novel leucyl-tRNA synthetase (LRS)-targeted mTORC1 inhibitor.

Jiyoun Lee, Jeewoo Lee, Changhoon Kim, 2016, Bioorganic & medicinal chemistry letters.

TWIK-1 BAC-GFP Transgenic Mice, an Animal Model for TWIK-1 Expression

Jiyoun Lee, E. Hwang, Sungbo Shim, 2021, Cells.

Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease.

Seo Yun Jung, Ki Duk Park, Jiyoun Lee, 2017, European journal of medicinal chemistry.

Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction.

Jiyoun Lee, Bongjin Moon, A. Pae, 2017, European journal of medicinal chemistry.

Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design.

M. Cui, Sun Choi, Jiyoun Lee, 2017, Journal of medicinal chemistry.

Mitochondria-Targeting Peptoids.

Jiyoun Lee, Jiwon Seo, Jieun Choi, 2018, Bioconjugate chemistry.

Synthesis and structure‐activity relationship of mitochondria‐targeting peptoids with varying hydrophobicity and cationic charge

Jiyoun Lee, Jiwon Seo, Soyoung Kim, 2021, Peptide Science.

Mitochondria-targeting peptides and peptidomimetics: recent progress and design principles.

Jiyoun Lee, Jiwon Seo, Soyoung Kim, 2019, Biochemistry.

High affinity antagonists of the vanilloid receptor.

Jiyoun Lee, P. Blumberg, Y. Suh, 2002, Molecular pharmacology.

Helicity modulation improves selectivity of antimicrobial peptoids.

Jiyoun Lee, Myung‐Han Yoon, R. Lund, 2020, ACS infectious diseases.

A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling.

David J. Anderson, T. Meade, Jiyoun Lee, 2005, Journal of the American Chemical Society.

Novel pyrimidoazepine analogs as serotonin 5-HT(2A) and 5-HT(2C) receptor ligands for the treatment of obesity.

Jiyoun Lee, Y. Cho, A. Pae, 2013, European journal of medicinal chemistry.

Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model.

Jiyoun Lee, J. Park, Min-Ji Kang, 2023, Experimental & molecular medicine.

Rational design, synthesis, and biological evaluation of progesterone-modified MRI contrast agents.

T. Meade, Jiyoun Lee, T. Woodruff, 2007, Chemistry & biology.

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase

Sarah E. Ewald, M. Bogyo, Jiyoun Lee, 2011, The Journal of experimental medicine.

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase

Sarah E. Ewald, M. Bogyo, Jiyoun Lee, 2011, Journal of Experimental Medicine.

Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumain.

M. Bogyo, Jiyoun Lee, 2012, Bioorganic & medicinal chemistry letters.

Effect of side chain hydrophobicity and cationic charge on antimicrobial activity and cytotoxicity of helical peptoids.

Jiyoun Lee, A. Barron, Jiwon Seo, 2018, Bioorganic & medicinal chemistry letters.