D. Horrobin

D. Horrobin, Y. Huang, P. Wainwright, 1993, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Modification of liver fatty acid metabolism in mice by n-3 and n-6 delta 6-desaturase substrates and products.

D. Horrobin, Y. Huang, P. Redden, 1991, Biochimica et biophysica acta.

Essential Fatty Acids in Tissue Phospholipids and Triglycerides of the Zinc-Deficient Rat

D. Horrobin, M. Manku, S. Cunnane, 1984, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Most biological effects of zinc deficiency corrected by γ-linolenic acid (18: 3ω6) but not by linoleic acid (18: 2ω6)

D. Horrobin, Y. Huang, S. Cunnane, 1982 .

Arachidonic acid: a common link in the biology of schizophrenia?

G. Reynolds, D. Horrobin, J. Laugharne, 1994, Archives of general psychiatry.

Possible Roles of Prostaglandins in Mediating Opioid Actions

D. Horrobin, 1982 .

Nutritional and medical importance of gamma-linolenic acid.

D. Horrobin, 1992, Progress in lipid research.

Metabolism of linoleic and α-linolenic acids in cultured cardiomyocytes: Effect of different N-6 and N-3 fatty acid Supplementation

David F. Horrobin, Silvana Hrelia, D. Horrobin, 1996 .

Essential fatty acid metabolism in long term primary cultures of rat cardiomyocytes: a beneficial effect of n-6:n-3 fatty acids supplementation

D. Horrobin, A. Lorenzini, A. Bordoni, 1999, Mechanisms of Ageing and Development.

Manipulation of lipid composition of rat heart myocytes aged in culture and its effect on alpha1-adrenoceptor stimulation.

D. Horrobin, A. Lorenzini, A. Bordoni, 1997, Biochimica et biophysica acta.

(Int. J. Cardiol., 17:241-255)The role of linoleic acid and its metabolites in the lowering of plasma cholesterol and the prevention of cardiovascular disease

D. Horrobin, Y. Huang, 1987 .

The role of linoleic acid and its metabolites in the lowering of plasma cholesterol and the prevention of cardiovascular disease.

D. Horrobin, Y. Huang, Y. S. Huang, 1987, International journal of cardiology.

The effects of gamma-linolenic acid on human breast cancer cell killing, lipid peroxidation and the production of Schiff-reactive materials

D. Horrobin, M. Manku, S. Takeda, 1992 .

Omega-6 and Omega-3 Essential Fatty Acids in Atherosclerosis

D. Horrobin, D. Horrobin, 1993, Seminars in thrombosis and hemostasis.

Medical Uses Of Essential Fatty Acids (EFAs)

D. Horrobin, 1993 .

ROLE OF PINEAL GLAND IN ÆTIOLOGY AND TREATMENT OF BREAST CANCER

D. Horrobin, T. Ghayur, R. Karmali, 1978, The Lancet.

The lateral cervical nucleus of the cat; an electrophysiological study.

D. Horrobin, 1966, Quarterly journal of experimental physiology and cognate medical sciences.

SCHIZOPHRENIA AS A PROSTAGLANDIN DEFICIENCY DISEASE

D. Horrobin, 1977, The Lancet.

Loss of delta-6-desaturase activity as a key factor in aging.

D. Horrobin, 1981, Medical hypotheses.

The possible roles of prostaglandin E1 and of essential fatty acids in mania, depression and alcoholism.

D. Horrobin, 1981, Progress in lipid research.

Most biological effects of zinc deficiency corrected by gamma-linolenic acid (18: 3 omega 6) but not by linoleic acid (18: 2 omega 6).

D. Horrobin, Y. Huang, S. Cunnane, 1982, Atherosclerosis.

Schizophrenia: the role of abnormal essential fatty acid and prostaglandin metabolism.

D. Horrobin, Y. Huang, Y. S. Huang, 1983, Medical hypotheses.

Stereospecific analysis of the major triacylglycerol species containing γ-linolenic acid in evening primrose oil and borage oil

D. Horrobin, J. Fahey, P. Redden, 1995 .

Regulation of the Expression of E-Cadherin on Human Cancer Cells by γ-Linolenic Acid (GLA)

R. Mansel, W. Jiang, D. Horrobin, 1995 .

A red cell membrane abnormality in a subgroup of schizophrenic patients: evidence for two diseases

D. Horrobin, K. Vaddadi, N. Morse-Fisher, 1994, Schizophrenia Research.

The possible role of prolactin in pre-eclampsia.

D. Horrobin, 1975, Zentralblatt fur Gynakologie.

Essential fatty acids and cardiovascular disease: the Edinburgh Artery Study

D. Horrobin, F. Fowkes, A. Lee, 1999, Vascular medicine.

Influence of omega-3 fatty acids on the prostaglandin-metabolism in healthy volunteers and patients suffering from PVD.

D. Horrobin, A. Gazsó, H. Sinzinger, 1992, Agents and actions. Supplements.

Changes of plasma lipids and long-chain n-3 and n-6 fatty acids in plasma, liver, heart and kidney phospholipids of rats fed variable levels of fish oil with or without cholesterol supplementation.

D. Horrobin, Y. Huang, Y. S. Huang, 1986, Biochimica et biophysica acta.

How do polyunsaturated fatty acids lower plasma cholesterol levels?

D. Horrobin, M. Manku, 1983, Lipids.

Alterations in plasma lipids, lipoproteins and high density lipoprotein subfractions in peripheral arterial disease.

D. Horrobin, F. Fowkes, H. Wilson, 1997, Atherosclerosis.

Essential Fatty Acids in Clinical Medicine

D. Horrobin, M. Manku, 1983 .

Randomized Controlled Trial of Antioxidants in Intermittent Claudication

D. Horrobin, G. Lowe, A. Rumley, 1997, Vascular medicine.

Relationship between plasma essential fatty acids and smoking, serum lipids, blood pressure and haemostatic and rheological factors.

D. Horrobin, G. Lowe, F. Fowkes, 1994, Prostaglandins, leukotrienes, and essential fatty acids.

Calcium metabolism, osteoporosis and essential fatty acids: a review.

D. Horrobin, M. Kruger, 1997, Progress in lipid research.

Patients with primary Sjögren's syndrome treated for two months with evening primrose oil.

D. Horrobin, J. Prause, R. Manthorpe, 1986, Scandinavian journal of rheumatology.

Gammalinolenic acid treatment of fatigue associated with primary Sjögren's syndrome

D. Horrobin, L. Jacobsson, E. Theander, 2002, Scandinavian journal of rheumatology.

Interaction between prostaglandins and calcium: The importance of bell-shaped dose-response curves

D. Horrobin, D. Horrobin, 1977 .

Phospholipid metabolism and depression: the possible roles of phospholipase A2 and coenzyme A‐independent transacylase

D. Horrobin, D. Horrobin, David F Horrobin, 2001, Human psychopharmacology.

Polyunsaturated fatty acid-induced cytotoxicity against tumor cells and its relationship to lipid peroxidation.

D. Horrobin, G. Ells, M. Bégin, 1988, Journal of the National Cancer Institute.

Mechanism of lipid peroxidation in cancer cells in response to gamma-linolenic acid (GLA) analyzed by GC-MS(I): Conjugated dienes with peroxyl (or hydroperoxyl) groups and cell-killing effects.

D. Horrobin, K. Chisholm, S. Takeda, 1993, Anticancer research.

Concentration-dependent effect of iron on gamma-linolenic acid toxicity in ZR-75-1 human breast tumor cells in culture.

D. Horrobin, K. Chisholm, R. Cantrill, 1993, Cancer letters.

Lipid peroxidation in human breast cancer cells in response to gamma-linolenic acid and iron.

D. Horrobin, M. Manku, G. Ells, 1992, Anticancer research.

Variations in temperature and oxygen content do not alter levels of thiobarbiturate reactive material in human breast tumour cells (ZR-75-1) incubated with gamma-linolenic acid.

D. Horrobin, K. Chisholm, R. Cantrill, 1993, Anticancer research.

A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy

D. Horrobin, H. Tritschler, D. Tomlinson, 1998, Diabetologia.

n-3 Essential fatty acids decrease weight gain in genetically obese mice

D. Horrobin, S. Cunnane, K. R. Mcadoo, 1986, British Journal of Nutrition.

Fatty acid changes in liver choline and ethanolamine glycerophospholipids in aspirin-treated rats fed linoleate, gamma-linolenate and fish oil.

D. Horrobin, Y. Huang, Y. S. Huang, 1989, Clinical physiology and biochemistry.

Disorders of Phospholipid Metabolism in Schizophrenia, Affective Disorders, and Neurodegenerative Disorders

D. Horrobin, 2001 .

Essential fatty acid supplementation in atopic dermatitis

D. Horrobin, Adrian Wilson, J. Berth-Jones, 1993, The Lancet.

Plasma bromine concentrations and lipid profiles.

D. Horrobin, N. Ward, F. Macintyre, 1991, Clinica chimica acta; international journal of clinical chemistry.

Interactions between zinc, essential fatty acids and prostaglandins: relevance to acrodermatitis enteropathica, total parenteral nutrition, the glucagonoma syndrome, diabetes, anorexia nervosa and sickle cell anaemia.

D. Horrobin, S. Cunnane, 1980, Medical hypotheses.

A Diet Enriched in α-Lipoic Acid Reverses the Age-Related Compromise in Antioxidant Defences in Rat Cortical Tissue

M. Lynch, D. Horrobin, D. Martin, 2000, Nutritional neuroscience.

Plasma thiols, cognitive function and ageing.

D. Horrobin, W. Smith, S. W. Welsh, 1996, Clinica chimica acta; international journal of clinical chemistry.

Increased release of prostaglandins from the mesenteric vascular bed of diabetic animals: the effects of glucose and insulin.

D. Horrobin, M. Soma, Y. Huang, 1986, Prostaglandins, leukotrienes, and medicine.

Fatty acid analysis of blood from violent offenders

D. Horrobin, F. Corrigan, R. F. Gray, 1994 .

Low-density lipoprotein fatty acids in patients with acute myocardial infarction

D. Horrobin, H. Wilson, F. Corrigan, 1999 .

Plasma, platelet, and aorta fatty acids composition in response to dietary n-6 and n-3 fats supplementation in a rat model of non-insulin-dependent diabetes.

D. Horrobin, N. Morse, R. Takahashi, 1988, Journal of nutritional science and vitaminology.

Schizophrenia: The illness that made us human

D. Horrobin, 1998, Schizophrenia Research.

Interrelationship between dietary protein, cholesterol and n-6 polyunsaturated fatty acid metabolism.

D. Horrobin, Y. Huang, K. Koba, 1993, Progress in lipid research.

Food, Micronutrients, and Psychiatry

D. Horrobin, 2002, International Psychogeriatrics.

The effects of gamma-linolenic acid on breast pain and diabetic neuropathy: possible non-eicosanoid mechanisms.

D. Horrobin, 1993, Prostaglandins, leukotrienes, and essential fatty acids.

Depleted red cell membrane essential fatty acids in drug-treated schizophrenic patients.

G. Reynolds, D. Horrobin, J. Laugharne, 1995, Journal of psychiatric research.

Fatty acid metabolism in health and disease: the role of delta-6-desaturase.

D. Horrobin, D. Horrobin, 1993, The American journal of clinical nutrition.

Prolactin: Role in Health and Disease

D. Horrobin, 1979, Drugs.

Essential fatty acid metabolism in cultured rat cardiomyocytes in response to either N-6 or N-3 fatty acid supplementation.

D. Horrobin, A. Bordoni, S. Hrelia, 1995, Biochemical and biophysical research communications.

New drug discovery techniques are not so revolutionary

D. Horrobin, 2001, BMJ : British Medical Journal.

Lipid metabolism, human evolution and schizophrenia.

D. Horrobin, 1999, Prostaglandins, leukotrienes, and essential fatty acids.

Response of tissue phospholipid fatty acid composition to dietary (n-6) and replacement with marine (n-3) and saturated fatty acids in the rat

D. Horrobin, Yung-Sheng Huang, B. Nassar, 1986 .

Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids.

R. Mansel, W. Jiang, D. Horrobin, 1998, Biochemical and biophysical research communications.

Inhibition of membrane ruffling and ezrin translocation by gamma linolenic acid.

R. Mansel, D. Horrobin, S. Hiscox, 1996, International journal of oncology.

Regulation of the expression of E-cadherin on human cancer cells by gamma-linolenic acid (GLA).

R. Mansel, D. Horrobin, W. Jiang, 1995, Cancer research.

Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-linolenic acid.

W. Jiang, D. Horrobin, W. Jiang, 1995, British Journal of Cancer.

Regulation of desmosomal cell adhesion in human tumour cells by polyunsaturated fatty acids

R. Mansel, W. Jiang, D. Horrobin, 1997, Clinical & Experimental Metastasis.

Concentration- and time-dependent effects of gamma-linolenic acid supplementation to tumor cells in culture.

D. Horrobin, A. Lorenzini, A. Pession, 1999, Prostaglandins, leukotrienes, and essential fatty acids.

Gamma linolenic acid regulates expression of maspin and the motility of cancer cells.

R. Mansel, D. Horrobin, W. Jiang, 1997, Biochemical and biophysical research communications.

The importance of linoleic acid metabolites in cancer metastasis and in the synthesis and actions of 13-HODE.

D. Horrobin, V. Ziboh, 1997, Advances in experimental medicine and biology.

Effect of dietary depletion and repletion of linoleic acid on renal fatty acid composition and urinary prostaglandin excretion.

D. Horrobin, Y. Huang, M. Manku, 1984, Prostaglandins, leukotrienes, and medicine.

(Prostaglandins, Leukotrienes Med., 15:223-228)Effect of dietary deletion and repletion of linoleic acid on renal fatty acid composition and urinary prostaglandin excretion

D. Horrobin, Yung-Sheng Huang, Manku, 1984 .

Abnormal membrane concentrations of 20 and 22-carbon essential fatty acids: a common link between risk factors and coronary and peripheral vascular disease?

D. Horrobin, 1995, Prostaglandins, leukotrienes, and essential fatty acids.

Essential fatty acids, prostaglandins, and alcoholism: an overview.

D. Horrobin, 1987, Alcoholism, clinical and experimental research.

Beyond conflict of interest. Non-financial conflicts of interest are more serious than financial conflicts.

D. Horrobin, 1999, BMJ.

Essential fatty acids and abnormal involuntary movements in the general male population: a study of men born in 1933.

D. Horrobin, L. Wilhelmsen, A. Rosengren, 1996, Prostaglandins, leukotrienes, and essential fatty acids.

Lowering cholesterol concentrations and mortality

D. Horrobin, 1990 .

gamma-Linolenic acid blocks cell cycle progression by regulating phosphorylation of p27kip1 and p57kip2 and their interactions with other cycle regulators in cancer cells.

R. Mansel, D. Horrobin, W. Jiang, 1998, International journal of oncology.

The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells.

R. Mansel, D. Horrobin, W. Jiang, 1998, British Journal of Cancer.

Gamma linolenic acid inhibits tyrosine phosphorylation of focal adhesion kinase and paxillin and tumour cell matrix interaction.

R. Mansel, D. Horrobin, S. Hiscox, 1996, International journal of oncology.

Expression of catenins in human cancer cells and its regulation by n-6 polyunsaturated fatty acids.

R. Mansel, D. Horrobin, W. Jiang, 1995, Anticancer research.

Effects of evening primrose oil in rheumatoid arthritis.

D. Horrobin, 1989, Annals of the rheumatic diseases.

Modulation of cytokine production in vivo by dietary essential fatty acids in patients with colorectal cancer.

D. Horrobin, S. Heys, O. Eremin, 1994, Clinical science.

Abnormalities in Plasma Essential Fatty Acid Levels in Women with Premenstrual Syndrome and with Non-malignant Breast Disease

R. Mansel, D. Horrobin, R. Mansel, 1991 .

Premenstrual syndrome and premenstrual breast pain (cyclical mastalgia): disorders of essential fatty acid (EFA) metabolism.

D. Horrobin, M. Manku, 1989, Prostaglandins, leukotrienes, and essential fatty acids.

EICOSAPENTAENOIC ACID TREATMENT IN SCHIZOPHRENIA ASSOCIATED WITH SYMPTOM REMISSION, NORMALISATION OF BLOOD FATTY ACIDS, REDUCED NEURONAL MEMBRANE PHOSPHOLIPID TURNOVER AND STRUCTURAL BRAIN CHANGES

J. Hajnal, G. Bydder, B. Puri, 2000, International journal of clinical practice.

The grants game

D. Horrobin, 1989, Nature.

The effect of dietary n−6 and n−3 polyunsaturated fatty acids on blood pressure and tissue fatty acid composition in spontaneously hypertensive rats

D. Horrobin, Yung-Sheng Huang, V. Simmons, 1989, Lipids.

Effects of calcium deprivation on n-6 fatty acid metabolism in growing rats.

D. Horrobin, Y. Huang, J. Mitchell, 1988, Biochemical medicine and metabolic biology.

PROLACTIN AND THE IMMUNE RESPONSE

D. Horrobin, I. Lauder, R. Karmali, 1974 .

Gamma linolenic acid up-regulates e-cadherin expression in human cancer cells

R. Mansel, W. Jiang, D. Horrobin, 1995 .

The mechanism of coronary artery spasm: roles of oxygen, prostaglandins, sex hormones and smoking.

D. Horrobin, M. Karmazyn, M. Manku, 1979, Medical hypotheses.

Coronary Artery Disease and Progesterone

D. Horrobin, M. Karmazyn, 1978 .

Ascorbic acid and prostaglandin synthesis.

D. Horrobin, 1996, Sub-cellular biochemistry.

(IRCS Med. Sci., 14:180-181)Effect of dexamethasone on the distribution of essential fatty acids in plasma and liver phospholipids

D. Horrobin, U. Das, Y. Huang, 1986 .

Uptake and distribution of cis-unsaturated fatty acids and their effect on free radical generation in normal and tumor cells in vitro.

D. Horrobin, U. Das, Y. Huang, 1987, Free radical biology & medicine.

Cytosolic phospholipase A2 type IVA is present in human red cells.

D. Horrobin, D. J. Macdonald, R. M. Boyle, 2004, Blood.

Plasma phospholipid essential fatty acids and prostaglandins in alcoholic, habitually violent, and impulsive offenders

D. Horrobin, M. Virkkunen, M. Manku, 1987, Biological Psychiatry.

Ethyl-eicosapentaenoate and dexamethasone resistance in therapy-refractory depression.

D. Horrobin, Cai Song, M. Uhr, 2004, The international journal of neuropsychopharmacology.

The Membrane Phospholipid Concept of Schizophrenia

D. Horrobin, C. Bennett, 1999 .

A pilot open case series of ethyl-EPA supplementation in the treatment of anorexia nervosa.

D. Horrobin, A. Ayton, A. Azaz, 2004, Prostaglandins, leukotrienes, and essential fatty acids.

Eicosapentaenoic acid in treatment-resistant depression.

B. Puri, S. Counsell, D. Horrobin, 2002, Archives of general psychiatry.

A theory of hypertension.

D. Horrobin, 1966, Lancet.

Rapid improvement of severe anorexia nervosa during treatment with ethyl-eicosapentaenoate and micronutrients

D. Horrobin, A. Ayton, A. Azaz, 2004, European Psychiatry.

Increased levels of cytosolic phospholipase A2 in dyslexics.

D. Horrobin, P. Ward, A. Glen, 2000, Prostaglandins, leukotrienes, and essential fatty acids.

Erythrocyte membrane fatty acid composition in children with atopic dermatitis compared to age‐matched controls

D. Horrobin, A. Bordoni, S. Hrelia, 1993, Acta paediatrica.

Treatment of Severe and Moderately Severe Atopic Dermatitis with Evening Primrose Oil (Epogam): a Multi-centre Study

D. Horrobin, R. Lindskov, C. Kennedy, 1991 .

Levels of essential and other fatty acids in plasma and red cell phospholipids from normal controls and patients with atopic eczema.

D. Horrobin, J. Burton, S. Oliwiecki, 1991, Acta dermato-venereologica.

Evening primrose oil in atopic eczema

D. Horrobin, CharlesJ. Stewart, 1990, The Lancet.

Essential fatty acids in the plasma phospholipids of patients with atopic eczema

D. Horrobin, M. Manku, J. Burton, 1984, The British journal of dermatology.

Lipid-lowering drugs and violence

D. Horrobin, 1989, British Journal of Psychiatry.

Stress Modulates Cholesterol-Induced Changes in Plasma and Liver Fatty Acid Composition in Rats Fed N-6 Fatty Acid-Rich Oils

D. Horrobin, Y. Huang, Yung-Sheng Huang, 1990, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Effect of glucose and insulin on release of prostaglandins from the mesenteric vascular bed in control and streptozotocin diabetic animals

D. Horrobin, M. Soma, M. Manku, 1986 .

Linoleic acid-induced fatty acid changes in platelet and aorta of the rat: Effect of age and cholesterol

D. Horrobin, R. Takahashi, 1988, Lipids.

Essential fatty acid status in cell membranes and plasma of patients with primary Sjogren's syndrome. Correlations to clinical and immunologic variables using a new model for classification and assessment of disease manifestations.

D. Horrobin, A. Wiik, K. Asmussen, 1998, Prostaglandins, leukotrienes, and essential fatty acids.

Schizophrenia as a membrane lipid disorder which is expressed throughout the body.

D. Horrobin, 1996, Prostaglandins, leukotrienes, and essential fatty acids.

Amelioration of both early and late radiation-induced damage to pig skin by essential fatty acids.

D. Horrobin, J. Hopewell, M. Rezvani, 1994, International journal of radiation oncology, biology, physics.

Effect of dietary olive oil non-glyceride fraction on plasma cholesterol level and liver phospholipid fatty acid composition

D. Horrobin, Yung-Sheng Huang, P. Redden, 1991 .

Omega-3 fatty acid ethyl-eicosapentaenoate, but not soybean oil, attenuates memory impairment induced by central IL-1beta administration.

D. Horrobin, Cai Song, 2004, Journal of lipid research.

Essential fatty acid supplementation during early alcohol abstinence.

D. Horrobin, J. Rotrosen, A. Wolkin, 1987, Alcoholism, clinical and experimental research.

A biochemical basis for the actions of lithium on behaviour and on immunity: relapsing and remitting disorders of inflammation and immunity such as multiple sclerosis or recurrent herpes as manic-depression of the immune system.

D. Horrobin, J. Lieb, 1981, Medical hypotheses.

Comparison of short-term feeding of dietary linoleic and gamma-linolenic acid on plasma and liver cholesterol and fatty acids in hyperchol esterolemic rats

D. Horrobin, Y. Huang, Y. S. Huang, 1988 .

Short-Term Effect of Dietary Cholesterol on Tissue n-6 Fatty Acids in Fat-Deficient Rats

D. Horrobin, Y. Huang, M. Manku, 1985, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Effect of Different Dietary Proteins on Plasma and Liver Fatty Acid Compositions in Growing Rats

D. Horrobin, Y. Huang, S. Cunnane, 1986, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

The development of an ELISA for group IVA phospholipase A2 in human red blood cells.

C. Leslie, D. Horrobin, A. Glen, 2015, Prostaglandins, leukotrienes, and essential fatty acids.

The relationship between schizophrenia and essential fatty acid and eicosanoid metabolism.

D. Horrobin, 1992, Prostaglandins, leukotrienes, and essential fatty acids.

Fatty Acids, Phospholipids, and Schizophrenia

D. Horrobin, 1997 .

Free radicals as possible mediators of the actions of interferon.

D. Horrobin, U. Das, G. Ells, 1986, Journal of free radicals in biology & medicine.

Neuroprotective effect of eicosapentaenoic acid in hippocampus of rats exposed to gamma-irradiation.

M. Lynch, D. Horrobin, Darren S. D. Martin, 2002, The Journal of biological chemistry.

Interactions between n-3 and n-6 essential fatty acids (EFAs) in the regulation of cardiovascular disorders and inflammation.

D. Horrobin, 1991, Prostaglandins, leukotrienes, and essential fatty acids.

Low prevalences of coronary heart disease (CHD), psoriasis, asthma and rheumatoid arthritis in Eskimos: are they caused by high dietary intake of eicosapentaenoic acid (EPA), a genetic variation of essential fatty acid (EFA) metabolism or a combination of both?

D. Horrobin, 1987, Medical hypotheses.

Prostaglandin precursors in plasma phospholipids of patients with psoriasis: effects of treatment with coal tar.

D. Horrobin, Y. Huang, M. Manku, 1984, Prostaglandins, leukotrienes, and medicine.

Prolactin: Physiology and Clinical Significance

D. Horrobin, 1973 .

Dietary nutrients and plasma n-3, n-6, saturated and monounsaturated fatty acids

D. Horrobin, F. Fowkes, G. Leng, 1997 .

Metabolism of Li-_-Linolenate (LiGLA) in Human Prostate, Ovarian, and Pancreatic Carcinomas Grown in Nude Mice

D. Horrobin, R. D. Antueno, M. Elliot, 1996 .

Vitamin E blocks the cytotoxic effect of gamma-linolenic acid when administered as late as the time of onset of cell death--insight into the mechanism of fatty acid induced cytotoxicity.

D. Horrobin, K. Chisholm, G. Ells, 1996, Cancer letters.

Is the main problem in free radical damage caused by radiation, oxygen and other toxins the loss of membrane essential fatty acids rather than the accumulation of toxic materials?

D. Horrobin, 1991, Medical hypotheses.

The effect of maternal supplementation with linoleic and gamma-linolenic acids on the fat composition and content of human milk: a placebo-controlled trial.

D. Horrobin, A. Cant, J. Shay, 1991, Journal of nutritional science and vitaminology.

Prolactin as a regulator of fluid and electrolyte metabolism in mammals.

D. Horrobin, 1980, Federation proceedings.

Essential fatty acids: molecular and cellular basis of their anti-cancer action and clinical implications.

D F Horrobin, W. Jiang, D. Horrobin, 1998, Critical reviews in oncology/hematology.

γ-Linolenic Acid Supplementation Can Affect Cancer Cell Proliferation via Modification of Fatty Acid Composition

D. Horrobin, A. Pession, A. Bordoni, 1996 .

High levels of polyunsaturated fat may inhibit cancer growth

D. Horrobin, 1996, BMJ.

The philosophical basis of drug target selection

D. Horrobin, 1996 .

DNA-protein and membrane-lipid: competing paradigms in biomedical research.

D. Horrobin, 1995, Medical hypotheses.

The modulation of radiation-induced damage to pig skin by essential fatty acids.

D. Horrobin, J. Hopewell, C. Scott, 1993, British Journal of Cancer.

Intracellular free Fatty-Acid release and lipid-peroxidation in cultured human breast-cancer cells in response to gamma-linolenic Acid with iron (gla + fe).

D. Horrobin, K. Chisholm, G. Ells, 1992, International journal of oncology.

The effect of n-6 fatty acids on normal and v-Ki ras transformed NIH-3T3 cells.

D. Horrobin, R. Cantrill, M. Elliot, 1992, Anticancer Research.

(Biochim. Biophys. Acta, 1082:319-327)Modification of liver fatty acid metabolism in mice by n-3 and n-6 Δ6 desaturase substrates and products

D. Horrobin, Yung-Sheng Huang, P. Redden, 1991 .

Commentary on the workshop statement: are we really sure that arachidonic acid and linoleic acid are bad things?

D. Horrobin, D. Horrobin, 2000, Prostaglandins, leukotrienes, and essential fatty acids.

The Treatment of Idiopathic Recurrent Urolithiasis With Fish Oil and Evening Primrose Oil — A Double-Blind Study

A. C. Buck, D. Horrobin, W. Smellie, 1994 .

Effect of high doses of essential fatty acids on the postviral fatigue syndrome

D. Horrobin, P. Behan, W. Behan, 1990, Acta neurologica Scandinavica.

The regulation of prostaglandin biosynthesis: negative feedback mechanisms and the selective control of formation of I and 2 series prostaglandins: relevance to inflammation and immunity.

D. Horrobin, 1980, Medical hypotheses.

Selective control of formation of 1 and 2 series prostaglandins: a new concept in the regulation of inflammation and immunity

D. Horrobin, M. Manku, S. Cunnane, 1980 .

Alteration of tissue zinc distribution and biochemical analysis of serum following pinealectomy in the rat.

D. Horrobin, M. Manku, S. Cunnane, 1979, Endocrine research communications.

Aluminum, cadmium, lipids and prevalence of dementia in people living near an aluminum smelter

D. Horrobin, N. Ward, F. Macintyre, 1993 .

Plasma essential fatty acids, cigarette smoking, and dietary antioxidants in peripheral arterial disease. A population-based case-control study.

P. Donnan, D. Horrobin, G. Lowe, 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

Reduced levels of prostaglandin precursors in the blood of atopic patients: defective delta-6-desaturase function as a biochemical basis for atopy.

D. Horrobin, M. Manku, N. Morse, 1982, Prostaglandins, leukotrienes, and medicine.

PROSTAGLANDINS AND SCHIZOPHRENIA

D. Horrobin, 1979, The Lancet.

Fatty acids in plasma phospholipids and cholesterol esters from identical twins concordant and discordant for schizophrenia

D. Horrobin, K. Ells, C. Bates, 1991, Schizophrenia Research.

Prevention of migraine by reducing prolactin levels.

D. Horrobin, 1973, Lancet.

Adrenic acid delta 4 desaturation and fatty acid composition in liver microsomes of spontaneously diabetic Wistar BB rats.

D. Horrobin, Y. Huang, V. Mimouni, 1994, Prostaglandins, leukotrienes, and essential fatty acids.

The effect of gamma-linolenic acid on plasma and membrane lipids and renal prostaglandin synthesis in older subjects.

D. Horrobin, B. Forette, S. Oravec, 2002, Bratislavske lekarske listy.

Essential fatty acid and prostaglandin metabolism in Sjögren's syndrome, systemic sclerosis and rheumatoid arthritis.

D. Horrobin, 1986, Scandinavian journal of rheumatology. Supplement.

A new concept of lifestyle-related cardiovascular disease: the importance of interactions between cholesterol, essential fatty acids, prostaglandin E1 and thromboxane A2.

D F Horrobin, D. Horrobin, 1980, Medical hypotheses.

The reversibility of cancer: the relevance of cyclic AMP, calcium, essential fatty acids and prostaglandin E1.

D. Horrobin, 1980, Medical hypotheses.

Brain Lipids in Ageing and in Alzheimer's Disease: A Review

D. Horrobin, S. W. Welsh, F. Corrigan, 1994 .

Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems.

D. Horrobin, C. Loder, J. Allawi, 2002, Medical hypotheses.

M. Lynch, D. Horrobin, B. McGahon, 1999, Neurobiology of Aging.

M. Lynch, D. Horrobin, B. McGahon, 1999, Neurobiology of aging.

M. Lynch, D. Horrobin, B. McGahon, 1999, Neuroscience.

Organotin compounds in trimethyltin-treated rats and in human brain in Alzheimer's Disease

J. Kelly, J. Besson, D. Horrobin, 1997, Human & experimental toxicology.

Essential fatty acid metabolism and its modification in atopic eczema.

D. Horrobin, 2000, The American journal of clinical nutrition.

Comparison of the grignard deacylation TLC and HPLC methods and high resolution 13C-NMR for the sn-2 positional analysis of triacylglycerols containing gamma-linolenic acid.

D. Horrobin, P. Redden, X. Lin, 1996, Chemistry and physics of lipids.

Essential Fatty Acids in the Management of Impaired Nerve Function in Diabetes

D. Horrobin, 1997, Diabetes.

15 – Lithium and Essential Fatty Acid Metabolism in Psychiatric Disorders, Herpes Virus Infections and Seborrhoeic Dermatitis

D. Horrobin, 1991 .

Effects of Lithium on Essential Fatty Acid and Prostaglandin Metabolism

D. Horrobin, 1990 .

A low toxicity maintenance regime, using eicosapentaenoic acid and readily available drugs, for mantle cell lymphoma and other malignancies with excess cyclin D1 levels.

D. Horrobin, David F Horrobin, 2003, Medical hypotheses.

Depression and bipolar disorder: relationships to impaired fatty acid and phospholipid metabolism and to diabetes, cardiovascular disease, immunological abnormalities, cancer, ageing and osteoporosis. Possible candidate genes.

D. Horrobin, C. Bennett, 1999, Prostaglandins, leukotrienes, and essential fatty acids.

Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients.

D. Horrobin, M. Peet, J. Shay, 1998, Journal of affective disorders.

The regulation of prostaglandin E1 formation: a candidate for one of the fundamental mechanisms involved in the actions of vitamin C.

D. Horrobin, M. Manku, M. Oka, 1979, Medical hypotheses.

Prolactin and zinc effects on rat vascular reactivity: possible relationship to dihomo-gamma-linolenic acid and to prostaglandin synthesis.

D. Horrobin, M. Karmazyn, M. Manku, 1979, Endocrinology.

A biochemical basis for alcoholism and alcohol-induced damage including the fetal alcohol syndrome and cirrhosis: interference with essential fatty acid and prostaglandin metabolism.

D. Horrobin, 1980, Medical hypotheses.

TREATMENT OF ATOPIC ECZEMA WITH EVENING PRIMROSE OIL

D. Horrobin, J. Burton, C. Lovell, 1981, The Lancet.

Plasma membrane phospholipid fatty acid composition of cultured skin fibroblasts from schizophrenic patients: comparison with bipolar patients and normal subjects

D. Horrobin, S. Mukherjee, S. Mahadik, 1996, Psychiatry Research.

Essential fatty acid metabolism in diseases of connective tissue with special reference to scleroderma and to Sjogren's syndrome.

D. Horrobin, 1984, Medical hypotheses.

Treatment of the Sicca syndrome and Sjogren's syndrome with E.F.A., pyridoxine and vitamin C.

D. Horrobin, C. G. McEwen, A. Campbell, 1981, Progress in lipid research.

Sjogren's syndrome and the sicca syndrome: The role of prostaglandin El deficiency. Treatment with essential fatty acids and vitamin C

D. Horrobin, A. Campbell, 1980 .

The nutritional regulation of T lymphocyte function.

D. Horrobin, T. Ghayur, M. Manku, 1979, Medical hypotheses.

Prolactin in Male and Female Reproduction

D. Horrobin, 1973 .

Differential killing of human carcinoma cells supplemented with n-3 and n-6 polyunsaturated fatty acids.

D F Horrobin, D. Horrobin, U. Das, 1986, Journal of the National Cancer Institute.

Abnormal content of n-6 and n-3 long-chain unsaturated fatty acids in the phosphoglycerides and cholesterol esters of parahippocampal cortex from Alzheimer's disease patients and its relationship to acetyl CoA content.

J. Besson, D. Horrobin, F. Corrigan, 1998, The international journal of biochemistry & cell biology.

Editorial: A revolutionary concept of the role of the nucleolus in cell division and its relevance to stem cell proliferation, cancer and ageing

D. Horrobin, 1980 .

D. Horrobin, C. Bennett, 2000, Prostaglandins, leukotrienes, and essential fatty acids.

New gene targets related to schizophrenia and other psychiatric disorders: enzymes, binding proteins and transport proteins involved in phospholipid and fatty acid metabolism.

D. Horrobin, C. Bennett, 1999, Prostaglandins, leukotrienes, and essential fatty acids.

Schizophrenia: the illness that made us human.

D. Horrobin, 1998 .

Neuroprotective actions of eicosapentaenoic acid on lipopolysaccharide‐induced dysfunction in rat hippocampus

M. Lynch, D. Horrobin, P. Lonergan, 2004, Journal of neurochemistry.

Apoptotic Changes in the Aged Brain Are Triggered by Interleukin-1β-induced Activation of p38 and Reversed by Treatment with Eicosapentaenoic Acid*

M. Lynch, D. Horrobin, V. Campbell, 2002, The Journal of Biological Chemistry.

Neuroprotective Effect of Eicosapentaenoic Acid in Hippocampus of Rats Exposed to γ-Irradiation*

M. Lynch, D. Horrobin, Darren S. D. Martin, 2002, The Journal of Biological Chemistry.

Essential fatty acids in clinical dermatology.

D. Horrobin, 1989, Journal of the American Academy of Dermatology.

The Kidneys and Urinary Tract

D. Horrobin, 1973 .

Plasma Cholesterol Ester Fatty Acids: A New Biochemical Abnormality in Obstructive Jaundice

D. Horrobin, M. Scriven, M. Puntis, 1995, HPB surgery : a world journal of hepatic, pancreatic and biliary surgery.

Study of plasma and red cell phospholipid fatty acids in extrahepatic cholestatic jaundice.

D. Horrobin, M. Scriven, M. Puntis, 1994, Gut.

Cellular basis of prolactin action: involvement of cyclic nucleotides, polyamines, prostaglandins, steroids, thyroid hormones, Na/K ATPases and calcium: relevance to breast cancer and the menstrual cycle.

D. Horrobin, 1979, Medical hypotheses.

PROLACTIN AND PROSTAGLANDIN SYNTHESIS

D. Horrobin, M. Manku, M. Greaves, 1974 .

CHLORPROPAMIDE/ALCOHOL FLUSHING AND PROSTAGLANDINS

D. Horrobin, M. Manku, 1980, The Lancet.

Effect of cholesterol supplementation on plasma and liver cholesteryl ester fatty acids in rats fed casein or soy protein

D. Horrobin, S. Cunnane, Yung-Sheng Huang, 1986 .

Omega-6 essential fatty acids : pathophysiology and roles in clinical medicine

D. Horrobin, 1990 .

γ-Linolenic acid dietary supplementation can reverse the aging influence on rat liver microsome Δ6-desaturase activity

D. Horrobin, A. Bordoni, S. Hrelia, 1991 .

Effects of linoleic and gamma-linolenic acids (efamol evening primrose oil) on fatty acid-binding proteins of rat liver

D. Horrobin, M. Garvey, A. Dutta-Roy, 2004, Molecular and Cellular Biochemistry.

Effects of high vitamin a intake on plasma and liver phospholipid and triglyceride fatty acid compositions in hamsters

D. Horrobin, M. Manku, Yung-Sheng Huang, 1985 .

Long-term ethanol consumption in the hamster: effects on tissue lipids, fatty acids and erythrocyte hemolysis.

D. Horrobin, S. Cunnane, K. R. Mcadoo, 1987, Annals of nutrition & metabolism.

The regulation of prostaglandin biosynthesis by the manipulation of essential fatty acid metabolism.

D. Horrobin, 1983, Reviews in pure & applied pharmacological sciences.

Eicosapentaenoic acid and arachidonic acid: collaboration and not antagonism is the key to biological understanding.

D F Horrobin, D. Horrobin, W. Christie, 2002, Prostaglandins, leukotrienes, and essential fatty acids.

Evening primrose oil and atopic eczema

D. Horrobin, CharlesJ. Stewart, 1990, The Lancet.

SCHIZOPHRENIA: RECONCILIATION OF THE DOPAMINE, PROSTAGLANDIN, AND OPIOID CONCEPTS AND THE ROLE OF THE PINEAL

D. Horrobin, 1979, The Lancet.

Essential polyunsaturated fatty acid and lipid peroxide levels in never-medicated and medicated schizophrenia patients

D. Horrobin, P. Ranjekar, S. Mahadik, 2003, Biological Psychiatry.

Effects of Oral Supplementation with Evening Primrose Oil for Six Weeks on Plasma Essential Fatty Acids and Uremic Skin Symptoms in Hemodialysis Patients

D. Horrobin, H. Echizen, J. Shay, 1999, Nephron.

n -6 Fatty acids and atopic eczema

D. Horrobin, 1998 .

Mechanisms of the selective cytotoxic actions of certain essential fatty acids.

D. Horrobin, R. Cantrill, G. Ells, 1997, Advances in experimental medicine and biology.

Selective Cytotoxicity of Certain Essential Fatty Acids Towards Tumour Cells

D. Horrobin, R. Cantrill, M. Elliot, 1993 .

Effects of repeated gestation and lactation on milk n-6 fatty acid composition in rats fed on a diet rich in 18:2n-6 or 18:3n-6

D. Horrobin, S. Churchill, P. Redden, 1992, British Journal of Nutrition.

Essential and other fatty acids in plasma in schizophrenics and normal individuals from Japan

D. Horrobin, N. Fisher, M. Manku, 1991, Biological Psychiatry.

Post-viral fatigue syndrome, viral infections in atopic eczema, and essential fatty acids.

D. Horrobin, 1990, Medical hypotheses.

Essential Fatty Acids, Immunity and Viral Infections

D. Horrobin, 1990 .

Protective effect of gamma-linolenic acid on aspirin-induced gastric hemorrhage in rats.

D. Horrobin, R. Drummond, Y. S. Huang, 1987, Digestion.

Influence of different dietary fatty acid sources on erythrocyte lipids and plasma and liver essential fatty acids in hamsters fed ethanol.

D. Horrobin, M. Manku, S. Cunnane, 1986, Annals of nutrition & metabolism.

Sex Differences in n-3 and n-6 Fatty Acid Metabolism in EFA-Depleted Rats

D. Horrobin, Y. Huang, Y. S. Huang, 1987, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Interactions of zinc with prostaglandins E1 and E2 in vascular smooth muscle.

D. Horrobin, M. Manku, S. Cunnane, 1981, Progress in lipid research.

The possible effect of diazepam on cancer development and growth.

D F Horrobin, J. Trosko, D. Horrobin, 1981, Medical hypotheses.

The international handbook of medical science.

D. Horrobin, A. Gunn, 1972 .

Myasthenia and prostaglandin E1.

D. Horrobin, 1979, Annals of Internal Medicine.

Myotonic dystrophy: a disease caused by functional zinc deficiency due to an abnormal zinc-binding ligand?

D. Horrobin, R. Morgan, 1980, Medical hypotheses.

n-6 Fatty acids and nervous system disorders

D. Horrobin, 1998 .

Are large clinical trials in rapidly lethal diseases usually unethical?

D. Horrobin, 2003, The Lancet.

Polyunsaturated fatty acids augment free radical generation in tumor cells in vitro.

D. Horrobin, U. Das, Y. Huang, 1987, Biochemical and biophysical research communications.

The role of essential fatty acids and prostaglandins in the premenstrual syndrome.

D. Horrobin, 1983, The Journal of reproductive medicine.

The Madness of Adam and Eve: How Schizophrenia Shaped Humanity

David F. Horrobin, D. Horrobin, 2002 .

Selective killing of human cancer cells by polyunsaturated fatty acids.

D F Horrobin, D. Horrobin, U. Das, 1985, Prostaglandins, leukotrienes, and medicine.

The paradox of antioxidants and cancer.

D. Horrobin, 2001, The American journal of clinical nutrition.

Polyunsaturated Fatty Acids and Human Cancer

D. Horrobin, 1989 .

The pituitary and hypothalamus

D. Horrobin, 1971 .

Tin and fatty acids in dementia.

D. Horrobin, N. Ward, A. V. van Rhijn, 1991, Prostaglandins, leukotrienes, and essential fatty acids.

Dietary manipulation of ethanol preference in the Syrian Golden hamster

D. Horrobin, S. Cunnane, Y. S. Huang, 1986, Pharmacology Biochemistry and Behavior.

Prostaglandins : physiology, pharmacology & clinical significance

D. Horrobin, 1978 .

Omega-3 fatty acid ethyl-eicosapentaenoate, but not soybean oil, attenuates memory impairment induced by central IL-1β administration Published, JLR Papers in Press, April 1, 2004. DOI 10.1194/jlr.M300526-JLR200

D. Horrobin, Cai Song, 2004, Journal of Lipid Research.

Dietary Ethyl-eicosapentaenoic Acid but not Soybean Oil Reverses Central Interleukin-1-induced Changes in Behavior, Corticosterone and Immune Response in Rats

B. Leonard, D. Horrobin, Cai Song, 2004, Stress.

Nutritional Considerations in Immunotoxicology

D. Horrobin, 1984 .

Multiple sclerosis: the rational basis for treatment with colchicine and evening primrose oil.

D. Horrobin, 1979, Medical hypotheses.

A dose-ranging study of the effects of ethyl-eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs.

D. Horrobin, Malcolm Peet, David F Horrobin, 2002, Archives of general psychiatry.

Effective clinical innovation: an ethical imperative

D. Horrobin, David F Horrobin, 2002, The Lancet.

Snakes and Other Reptiles

D. Horrobin, 1971 .

Cerebral metabolism in male patients with schizophrenia who have seriously and dangerously violently offended: a 31P magnetic resonance spectroscopy study.

B. Puri, S. Counsell, D. Horrobin, 2004, Prostaglandins, leukotrienes, and essential fatty acids.

Cytotoxicity and genotoxicity of lipid-oxidation products. Discussion

D. Horrobin, H. Esterbauer, F. Muskiet, 1993 .

The membrane hypothesis of schizophrenia

David F. Horrobin, D. Horrobin, K. Vaddadi, 1994, Schizophrenia Research.

Fatty acid levels in the brains of schizophrenics and normal controls

D. Horrobin, M. Manku, H. Hillman, 1991, Biological Psychiatry.

Essential fatty acids in plasma phospholipids in schizophrenics

D. Horrobin, K. Vaddadi, M. Manku, 1989, Biological Psychiatry.

International research communication system.

D. Horrobin, 1973, The Lancet.

Possible relevance of phospholipid abnormalities and genetic interactions in psychiatric disorders: the relationship between dyslexia and schizophrenia.

D. Horrobin, C. Hudson, A. Glen, 1995, Medical hypotheses.

Essential fatty acid and lipid profiles in plasma and erythrocytes in patients with multiple sclerosis 14

D. Horrobin, S. Cunnane, P. Dore‐Duffy, 2005 .

Essential fatty acid and lipid profiles in plasma and erythrocytes in patients with multiple sclerosis.

D. Horrobin, S. Cunnane, P. Dore‐Duffy, 1989, The American journal of clinical nutrition.

Membrane fatty acids, niacin flushing and clinical parameters.

S. Cooper, D. Horrobin, K. Vaddadi, 1996, Prostaglandins, leukotrienes, and essential fatty acids.

Chapter 3 The lipid hypothesis of schizophrenia

D. Horrobin, 2002 .

Genetic variant near cytosolic phospholipase A2 associated with schizophrenia

H. Meltzer, D. Horrobin, J. Kennedy, 1996, Schizophrenia Research.

The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental concept of schizophrenia

D. Horrobin, 1998, Schizophrenia Research.

Heme-induced cell adhesion in the pathogenesis of sickle-cell disease and inflammation

D. Horrobin, 2001 .

PROLACTIN AND MYOCARDIAL INFARCTION

D. Horrobin, M. Tynan, D. Reid, 1973 .

Changes in dietary fatty acids alter phospholipid fatty acid composition in selected regions of rat brain

D. Horrobin, E. Theodorsson, Í. Marteinsdóttir, 1998, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

The possible role of prostaglandin E1 deficiency in the immunological abnormalities seen in schizophrenia

D. Horrobin, 1980 .

Letter: Prolactin and the immune response.

D. Horrobin, I. Lauder, R. Karmali, 1974, The Lancet.

Magnesium and malnutrition.

D. Horrobin, 1967, Lancet.

Contrasting effects of low or high copper intake on rat tissue lipid essential fatty acid composition.

D. Horrobin, M. Manku, S. Cunnane, 1985, Annals of nutrition & metabolism.

Magnesium deficiency in the rat increases tissue levels of docosahexaenoic acid.

D. Horrobin, M. Soma, S. Cunnane, 1985, The Journal of nutrition.

Disorders of Fluid and Electrolyte Balance

D. Horrobin, 1973 .

Fatty Acid Distribution in Plasma Phospholipids in Normal Individuals from Different Geographical Locations

D. Horrobin, M. Manku, N. Morse-Fisher, 1991 .

The effects of evening primrose oil, safflower oil and paraffin on plasma fatty acid levels in humans: choice of an appropriate placebo for clinical studies on primrose oil.

D. Horrobin, M. Manku, N. Morse-Fisher, 1991, Prostaglandins, leukotrienes, and essential fatty acids.

Long-term potentiation in aged rats is restored when the age-related decrease in polyunsaturated fatty acid concentration is reversed.

M. Lynch, D. Horrobin, D. Martin, 2002, Prostaglandins, leukotrienes, and essential fatty acids.

Referees and research administrators: barriers to scientific research?

D F Horrobin, D. Horrobin, 1974, British medical journal.

Antidromic and synaptic responses in the cat's gracile nucleus to cerebellar stimulation

D. Horrobin, G. Gordon, 1967 .

Essential fatty acid metabolism and its modification in atopic eczema 1 , 2

D. Horrobin, 2022 .

Meta‐analysis of placebo‐controlled studies of the efficacy of Epogam in the treatment of atopic eczema. Relationship between plasma essential fatty acid changes and clinical response

Daniel J. Gould, D. Horrobin, M. Manku, 1989, The British journal of dermatology.

Depletion of docosahexaenoic acid in red blood cell membranes of depressive patients.

D. Horrobin, M. Peet, J. Shay, 1998, Biochemical Society transactions.

Ethyl-EPA in Alzheimer's disease--a pilot study.

D. Horrobin, P. Boston, C. Bennett, 2004, Prostaglandins, leukotrienes, and essential fatty acids.

Effects of dietary n-3 or n-6 fatty acids on interleukin-1beta-induced anxiety, stress, and inflammatory responses in rats.

B. Leonard, D. Horrobin, Cai Song, 2003, Journal of lipid research.

Ethyl-EPA in Huntington disease

S. Hersch, M. Hayden, C. Ross, 2005, Neurology.

A dose-ranging exploratory study of the effects of ethyl-eicosapentaenoate in patients with persistent schizophrenic symptoms.

D. Horrobin, M. Peet, 2002, Journal of psychiatric research.

EICOSAPENTAENOIC ACID IN TREATMENT‐RESISTANT DEPRESSION ASSOCIATED WITH SYMPTOM REMISSION, STRUCTURAL BRAIN CHANGES AND REDUCED NEURONAL PHOSPHOLIPID TURNOVER

B. Puri, S. Counsell, D. Horrobin, 2001, International journal of clinical practice.

Abnormal essential fatty acid metabolism in Darier's disease.

D. Horrobin, A. Oxholm, P. Oxholm, 1990, Archives of dermatology.

Letter: Prolactin and myocardial infarction.

D. Horrobin, M. Tynan, D. Reid, 1973, Lancet.

Comparison of the metabolism of alpha-linolenic acid and its delta 6 desaturation product, stearidonic acid, in cultured NIH-3T3 cells.

D. Horrobin, R. Cantrill, Y. S. Huang, 1993, Lipids.

Evening primrose oil and premenstrual syndrome

D. Horrobin, 1990, The Medical journal of Australia.

PROGESTERONE AND PRE-ECLAMPSIA

D. Horrobin, 1968 .

Innovation in the pharmaceutical industry

D F Horrobin, D. Horrobin, 2000, Journal of the Royal Society of Medicine.

SOME EFFECTS OF LONG-TERM PROGESTERONE TREATMENT IN RABBITS AND THEIR RELEVANCE TO PRE-ECLAMPSIA

D. Horrobin, 1968 .

DIABETIC RETINOPATHY AND PROLACTIN

E. N. Cole, D. Horrobin, John R. Anderson, 1974 .

Medical physiology and biochemistry

D. Horrobin, 1968 .

Ethyl-eicosapentaenoic acid ingestion prevents corticosterone-mediated memory impairment induced by central administration of interleukin-1β in rats

B. Leonard, D. Horrobin, C. Song, 2004, Molecular Psychiatry.

Hypothesis: prostaglandins and migraine.

D. Horrobin, 1977, Headache.

Probable role of zinc in the mobilization of dihomo-γ-linolenic acid and in the desaturation of linoleic acid

D. Horrobin, S. Cunnane, 1981 .

Role of zinc in linoleic acid desaturation and prostaglandin synthesis.

D. Horrobin, Y. Huang, S. Cunnane, 1981, Progress in lipid research.

Case reports in prostaglandins and medicine

D. Horrobin, M. Karmazyn, 1979 .

D.V.T. after vitamin C?

D. Horrobin, 1973, Lancet.

Muscular Dystrophies and Thymic Deficiency

D. Horrobin, 1983 .

Exogenous gamma-linolenic acid alters hormone stimulated cyclic AMP levels in U937 cells.

D. Horrobin, R. Cantrill, G. Ells, 1996, Cancer Letters.

Effect of gamma-linolenic acid on plasma and membrane lipids and renal prostaglandins in old subjects.

D. Horrobin, B. Forette, S. Oravec, 1999, British journal of clinical pharmacology.

The vascular response to zinc varies seasonally: effect of pinealectomy and melatonin.

D. Horrobin, M. Manku, S. Cunnane, 1980, Chronobiologia.

The role of a prostaglandin E1 deficiency in schizophrenia: interactions with dopamine and opiates

D. Horrobin, M. Manku, S. Cunnane, 1980 .

The roles of essential fatty acids in the development of diabetic neuropathy and other complications of diabetes mellitus.

D. Horrobin, 1988, Prostaglandins, leukotrienes, and essential fatty acids.

Essential Fatty Acids in Alzheimer's Disease a

D. Horrobin, F. Corrigan, A. V. Rhijn, 1991, Annals of the New York Academy of Sciences.

PROSTAGLANDINS AND SCHIZOPHRENIA

D. Horrobin, D. Rubinow, 1980, The Lancet.

Dietary Supplementation with Zinc Sulphate, Sodium Selenite and Fatty Acids in Early Dementia of Alzheimer's Type. II: Effects on Lipids

D. Horrobin, F. Macintyre, F. Corrigan, 1991 .

Regulation of blood glucose

D. Horrobin, 1971 .

DIAZEPAM AND BREAST CANCER

D. Horrobin, DavidF. Horrobin, 1981, The Lancet.

Selective incorporation of n-3 and n-6 fatty acids in essential fatty acid deficient rats in response to short-term oil feeding.

D. Horrobin, Y. S. Huang, R. Hancock, 1987, Biochemistry international.

Unsaturated lipids: a new approach to the treatment of cancer.

D. Horrobin, 1994, World review of nutrition and dietetics.

The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism.

D. Horrobin, F. Muskiet, M. Fokkema, 2003, Prostaglandins, leukotrienes, and essential fatty acids.

Cholesterol metabolism and violence: a study of individuals convicted of violent crimes.

D. Horrobin, A. V. van Rhijn, F. Corrigan, 1993, Neuroreport.

Peer review of grant applications: a harbinger for mediocrity in clinical research?

D. Horrobin, David F Horrobin, 1996, The Lancet.

Peer review of statistics in medical research [2] (multiple letters)

D. Moher, D. Altman, K. Schulz, 2002 .

Peer review of statistics in medical research. Rationale for requiring power calculations is needed.

David F Horrobin, D. Horrobin, 2002, British medical journal.

MIND AND CANCER

D. Horrobin, T. Ghayur, R. Karmali, 1979, The Lancet.

Prostaglandin Deficiency and Endorphin Excess in Schizophrenia : The Case for Treatment with Penicillin , Zinc , and Evening Primrose Oil

D. Horrobin, 2007 .

Polyunsaturated Oils of Marine and Plant Origins and Their Uses in Clinical Medicine

D. Horrobin, 1989 .

(IRCS Med. Sci., 13:684-687)Minerals, trace elements, and vitamins interact with essential fatty acids and prostaglandins to prevent hypertension, thrombosis, hypercholesterolemia and atherosclerosis and their attendant complications

D. Horrobin, U. Das, S. Cunnane, 1985 .

Is the triene/tetraene ratio always a valid indicator of functional essential fatty acid deficiency?

D. Horrobin, S. Cunnane, 1981 .

The Development of Man

David F. Horrobin, D. Horrobin, 1971 .

Effect of essential fatty acid depletion on tissue phospholipid fatty acids in spontaneously hypertensive and normotensive rats

D. Horrobin, Yung-Sheng Huang, D. Mills, 1989, Lipids.

omega-3 Fatty acid for schizophrenia.

D. Horrobin, 2003, The American journal of psychiatry.

Fatty Acid Composition of Regular Rat Chow and of the Evening Primrose Oil or Fish Body Oil Added to the Chow Fatty acid

D. Horrobin, M. Manku, J. Mtabaji, 2005 .

MRI changes in multiple sclerosis following treatment with lofepramine and l-phenylalanine

J. Hajnal, G. Bydder, B. Puri, 2001, NeuroReport.

Ideas in biomedical science: reasons for the foundation of Medical Hypotheses.

D. Horrobin, 1976, Medical hypotheses.

The roles of prostaglandins and prolactin in depression, mania and schizophrenia.

D. Horrobin, 1977, Postgraduate medical journal.

Short-term diabetes increases triacylglycerol arachidonic acid content in the rat liver.

D. Horrobin, V. Billard, Y. Watanabe, 1987, Biochimica et biophysica acta.

MRI and neuropsychological improvement in Huntington disease following ethyl-EPA treatment

J. Hajnal, G. Bydder, B. Puri, 2002, Neuroreport.

Dilinoleoyl-mono-gamma-linolenin (DLMG) and Digamma- linolenoyl-monolinolein (DGML): Naturally Occurring Structured Triacylglycerols in Evening Primrose Oil

D. Horrobin, P. Redden, X. Lin, 1998 .

Separation and quantification of the triacylglycerols in evening primrose and borage oils by reversed-phase high-performance liquid chromatography

D. Horrobin, Yung-Sheng Huang, P. Redden, 1995 .

Fatty acid composition of serum phospholipids in an elderly institutionalized Japanese population.

D. Horrobin, H. Ito, R. Takahashi, 1991, Journal of nutritional science and vitaminology.

The prostaglandin outflow from perfused mesenteric vasculature of rats fed different fats.

D. Horrobin, Y. Huang, Y. S. Huang, 1989, Prostaglandins, leukotrienes, and essential fatty acids.

Phospholipases: in search of a genetic base of schizophrenia.

D. Horrobin, C. Hudson, A. Lin, 1996, Prostaglandins, leukotrienes, and essential fatty acids.

Polyunsaturated fatty acids and colchicine in multiple sclerosis.

D. Horrobin, M. Botez, T. Botez, 1979, British medical journal.

Letter: Diabetic retinopathy and prolactin.

E. N. Cole, D. Horrobin, P. Hunter, 1974, The Lancet.

Lithium and Dermatological Disorders

D. Horrobin, 1990 .

Diet and breast cancer: the possible connection with sugar consumption.

D. Horrobin, S. Seely, 1983, Medical hypotheses.

Effects of dietary linoleic acid on growth and liver phospholipid fatty acid composition in intact and gonadectomized rats.

D. Horrobin, Yung-Sheng Huang, Y. Watanabe, 1990 .

The Nature of Scientific Research

D. Horrobin, 1969 .

Effects of cholesterol on viability and (n - 6) fatty acid metabolism in cultured human monocyte-like cells (U937).

D. Horrobin, Y. S. Huang, A. Howie, 1992, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Gamma-linolenic acid dietary supplementation can reverse the aging influence on rat liver microsome delta 6-desaturase activity.

D. Horrobin, A. Bordoni, S. Hrelia, 1991, Biochimica et Biophysica Acta.

Effects of dietary n-3 or n-6 fatty acids on interleukin-1β-induced anxiety, stress, and inflammatory responses in rats Published, JLR Papers in Press, July 1, 2003. DOI 10.1194/jlr.M300217-JLR200

B. Leonard, D. Horrobin, Cai Song, 2003, Journal of Lipid Research.

(Nutrition, 04:337-341)Clinical significance of essential fatty acids

D. Horrobin, U. Das, S. Cunnane, 1988 .

Glittering prizes for research support

D. Horrobin, 1986, Nature.

The female sex cycle.

D. Horrobin, 1969, Journal of theoretical biology.

Plasma lipoproteins and apolipoproteins in individuals convicted of violent crimes.

D. Horrobin, F. Corrigan, E. Skinner, 1997 .

Natural killer cell functions are related to the cell membrane composition of essential fatty acids: differences in healthy persons and patients with primary Sjögren's syndrome.

D. Horrobin, B. Pedersen, P. Oxholm, 1992, Clinical and experimental rheumatology.

Metabolism of linoleic and α-linolenic acids in cultured cardiomyocytes: Effect of different N-6 and N-3 fatty acid supplementation

David F. Horrobin, Silvana Hrelia, D. Horrobin, 1996, Molecular and Cellular Biochemistry.

Essential Fatty Acids in the Management of Diabetic Neuropathy

D. Horrobin, 1996 .

Reduced neuronal membrane phospholipid turnover and normalization of blood fatty acids associated with symptom remission in a patient with schizophrenia treated solely with eicosapentaenoic acid

J. Hajnal, B. Puri, N. Saeed, 2000, Schizophrenia Research.

Schizophrenia: a biochemical disorder?

D. Horrobin, 1980, Biomedicine / [publiee pour l'A.A.I.C.I.G.].

HUMAN GROWTH AFTER BIRTH

D. Horrobin, 1974, The Ulster Medical Journal.

CRITICAL CLOSING PRESSURE

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BONE RESORPTION BY BREAST-CANCER TISSUE

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Medical hubris: A reply to Ivan Illich

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The Kenya Coast

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Innovation in the pharmaceutical industry

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DIAZEPAM AS TUMOUR PROMOTER

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