J. Contrera

发表

Progress in QSAR toxicity screening of pharmaceutical impurities and other FDA regulated products.

Naomi L Kruhlak, R Daniel Benz, Edwin J Matthews, 2007, Advanced drug delivery reviews.

Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose.

N. Kruhlak, J. Contrera, R. Benz, 2004, Regulatory toxicology and pharmacology : RTP.

An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: I. Identification of carcinogens using surrogate endpoints.

N. Kruhlak, J. Contrera, R. Benz, 2006, Regulatory toxicology and pharmacology : RTP.

In silico screening of chemicals for bacterial mutagenicity using electrotopological E-state indices and MDL QSAR software.

N. Kruhlak, J. Contrera, R. Benz, 2005, Regulatory toxicology and pharmacology : RTP.

Assessment of the health effects of chemicals in humans: I. QSAR estimation of the maximum recommended therapeutic dose (MRTD) and no effect level (NOEL) of organic chemicals based on clinical trial data.

N. Kruhlak, J. Contrera, R. Benz, 2004, Current drug discovery technologies.

A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSAR-ES software.

J. Contrera, E. Matthews, 1998, Regulatory toxicology and pharmacology : RTP.

An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: II. Identification of genotoxicants, reprotoxicants, and carcinogens using in silico methods.

N. Kruhlak, J. Contrera, R. Benz, 2006, Regulatory toxicology and pharmacology : RTP.

Predicting the carcinogenic potential of pharmaceuticals in rodents using molecular structural similarity and E-state indices.

J. Contrera, E. Matthews, R. Daniel Benz, 2003, Regulatory toxicology and pharmacology : RTP.

Comparison of MC4PC and MDL-QSAR rodent carcinogenicity predictions and the enhancement of predictive performance by combining QSAR models.

Naomi L Kruhlak, R Daniel Benz, Edwin J Matthews, 2007, Regulatory toxicology and pharmacology : RTP.

Validation of Toxtree and SciQSAR in silico predictive software using a publicly available benchmark mutagenicity database and their applicability for the qualification of impurities in pharmaceuticals.

Joseph F Contrera, J. Contrera, 2013, Regulatory toxicology and pharmacology : RTP.

A comprehensive model for reproductive and developmental toxicity hazard identification: II. Construction of QSAR models to predict activities of untested chemicals.

Naomi L Kruhlak, Gilles Klopman, Edwin J Matthews, 2007, Regulatory toxicology and pharmacology : RTP.

Development of a Phospholipidosis Database and Predictive Quantitative Structure-Activity Relationship (QSAR) Models

Naomi L Kruhlak, Sydney S Choi, Joseph F Contrera, 2008, Toxicology mechanisms and methods.

Effects of repeated fenfluramine administration on indices of monoamine function in rat brain: pharmacokinetic, dose response, regional specificity and time course data.

J. Contrera, E. D. De Souza, G. Battaglia, 1990, The Journal of pharmacology and experimental therapeutics.

Methylphenidate and pemoline do not cause depletion of rat brain monoamine markers similar to that observed with methamphetamine.

J. Contrera, E. D. De Souza, G. Battaglia, 1989, Toxicology and applied pharmacology.

Extraction of an erythropoietin-producing factor from a particulate fraction of rat kidney.

J. Contrera, A. S. Gordon, A. Weintraub, 1966, Blood.

An Evaluation of the Hemizygous Transgenic Tg.AC Mouse for Carcinogenicity Testing of Pharmaceuticals. I. Evidence for a Confounding Nonresponder Phenotype

Karl K. Lin, B. Rosenzweig, K. Thompson, 1998, Toxicologic pathology.

Inhibition of dopamine beta oxidase by adrenalone.

J. Contrera, M. Goldstein, 1961, Nature.

BINDING OF [3H]KAINIC ACID, AN ANALOGUE OF l‐GLUTAMATE, TO BRAIN MEMBRANES

J. Contrera, M. Kuhar, J. Simon, 1976, Journal of neurochemistry.

Dopamine and norepinephrine depletion in ring doves fed DDE, dieldrin, and Aroclor 1254.

J. Contrera, G. H. Heinz, E. Hill, 1980, Toxicology and applied pharmacology.

Depletion of Cardiac Norepinephrine during Two Forms of Hemolytic Anemia in the Rat

J. Swann, J. Contrera, 1976, Circulation research.

Altered state of cardiac sympathetic nerves during immunologically induced anemia.

J. Swann, J. Contrera, E. W. Spannhake, 1978, European journal of pharmacology.

A Systemic Exposure-Based Alternative to the Maximum Tolerated Dose for Carcinogenicity Studies of Human Therapeutics

J. Contrera, A. Jacobs, M. Mehta, 1995 .

Fenfluramine selectively and differentially decreases the density of serotonergic nerve terminals in rat brain: evidence from immunocytochemical studies.

J. Contrera, E. D. De Souza, N. Appel, 1989, The Journal of pharmacology and experimental therapeutics.

In vivo transgenic bioassays and assessment of the carcinogenic potential of pharmaceuticals.

J. Contrera, J. Degeorge, J. F. Contrera, 1998, Environmental health perspectives.

The substrate specificity of phenylamine-beta-hydroxylase.

J. Contrera, M. Goldstein, 1962, The Journal of biological chemistry.

Cobalt-induced alterations in plasma proteins, proteases and kinin system of the rat.

J. Contrera, R. Smith, R. Smith, 1974, Biochemical pharmacology.

Prediction of rodent carcinogenic potential of naturally occurring chemicals in the human diet using high-throughput QSAR predictive modeling.

Luis G Valerio, Kirk B Arvidson, Joseph F Contrera, 2007, Toxicology and applied pharmacology.

Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.

Naomi L Kruhlak, R Daniel Benz, Edwin J Matthews, 2004, Current drug discovery technologies.

Intraventricular 6-hydroxydopamine lowers isolation-induced fighting behavior in male mice

J. Crawley, J. Contrera, J. F. Contrera, 1976, Pharmacology Biochemistry and Behavior.

CHOLINE: HIGH AFFINITY UPTAKE IN VIVO BY RAT HIPPOCAMPUS

J. Contrera, G. Samaras, J. F. Contrera, 1977, Journal of neurochemistry.

Plasma and Urinary Levels of Erythropoietin in Cooley's Anemia *

J. Contrera, A. S. Gordon, A. Weintraub, 1964, Annals of the New York Academy of Sciences.

Carcinogenicity testing and the evaluation of regulatory requirements for pharmaceuticals.

J. Contrera, A. Jacobs, J. Degeorge, 1997, Regulatory toxicology and pharmacology : RTP.

EXTRACTION OF ERYTHROPOIETIN FROM KIDNEYS OF HYPOXIC AND PHENYLHYDRAZINE-TREATED RATS.

J. Contrera, A. S. Gordon, A. Weintraub, 1965, Blood.

Renal Erythropoietic Factor: Role of Ions and Vasoactive Agents in Erythropoietin Formation

J. Contrera, A. S. Gordon, G. Cooper, 1967, Science.

Comparison of the effects of repeated oral versus subcutaneous fenfluramine administration on rat brain monoamine neurons: Pharmacokinetic and dose-response data

J. Contrera, N. Appel, R. Zaczek, 1991, Pharmacology Biochemistry and Behavior.

Effects of high‐dose fenfluramine treatment on monoamine uptake sites in rat brain: Assessment using quantitative autoradiography

J. Contrera, E. Desouza, N. Appel, 1990, Synapse.

Role for brain corticotropin-releasing factor in the weight-reducing effects of chronic fenfluramine treatment in rats.

C. Nemeroff, M. Owens, J. Contrera, 1991, Endocrinology.

The formation of 3, 4-dihydroxyphenylethanol and 3-methoxy-4-hydroxyphenylethanol from 3, 4-dihydroxy-phenylethylamine in the rat.

S. Pomerantz, J. Contrera, A. Friedhoff, 1961, The Journal of biological chemistry.

In Silico Screening of Chemicals for Genetic Toxicity Using MDL-QSAR, Nonparametric Discriminant Analysis, E-State, Connectivity, and Molecular Property Descriptors

Naomi L. Kruhlak, N. Kruhlak, J. Contrera, 2008, Toxicology mechanisms and methods.

Inhibition of dopamine beta-oxidase by imipramine.

J. Contrera, M. Goldstein, 1961, Biochemical pharmacology.

Understanding Genetic Toxicity Through Data Mining: The Process of Building Knowledge by Integrating Multiple Genetic Toxicity Databases

R Benigni, A M Richard, C Yang, 2008, Toxicology mechanisms and methods.

Genetic toxicity assessment: employing the best science for human safety evaluation. Part I: Early screening for potential human mutagens.

Joseph F Contrera, David Jacobson-Kram, J. Contrera, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Does social environment decrease propensity to fight in male mice?

J. Crawley, W. Schleidt, J. Contrera, 1975, Behavioral biology.

Use of in silico systems and expert knowledge for structure-based assessment of potentially mutagenic impurities.

Scott Boyer, Nigel Greene, Lutz Müller, 2013, Regulatory toxicology and pharmacology : RTP.

Combined Use of MC4PC, MDL-QSAR, BioEpisteme, Leadscope PDM, and Derek for Windows Software to Achieve High-Performance, High-Confidence, Mode of Action–Based Predictions of Chemical Carcinogenesis in Rodents

Naomi L Kruhlak, R Daniel Benz, Chihae Yang, 2008, Toxicology mechanisms and methods.

QSAR modeling of carcinogenic risk using discriminant analysis and topological molecular descriptors.

Joseph F Contrera, Lowell H Hall, Philip Maclaughlin, 2005, Current drug discovery technologies.

The Renal Erythropoietic Factor (REF). III. Enzymatic Role in Erythropoietin Production.∗

J. Contrera, A. S. Gordon, G. Cooper, 1967, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

PLASMA AND RENAL CLEARANCE OF EXOGENOUS ERYTHROPOIETIN IN THE DOG.

J. Contrera, A. S. Gordon, E. Becker, 1964, The American journal of physiology.

Improved in silico prediction of carcinogenic potency (TD50) and the risk specific dose (RSD) adjusted Threshold of Toxicological Concern (TTC) for genotoxic chemicals and pharmaceutical impurities.

Joseph F Contrera, J. Contrera, J. F. Contrera, 2011, Regulatory toxicology and pharmacology : RTP.

A comprehensive model for reproductive and developmental toxicity hazard identification: I. Development of a weight of evidence QSAR database.

Naomi L Kruhlak, Edwin J Matthews, Joseph F Contrera, 2007, Regulatory toxicology and pharmacology : RTP.

Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part C: use of QSAR and an expert system for the estimation of the mechanism of action of drug-induced hepatobiliary and urinary tract toxicities.

Naomi L Kruhlak, R Daniel Benz, Edwin J Matthews, 2009, Regulatory toxicology and pharmacology : RTP.

Erythropoietin: Production by a Particulate Fraction of Rat Kidney

J. Contrera, A. S. Gordon, Joseph F. Contrera, 1966, Science.

The inhibition of norepinephrine and epinephrine synthesis in vitro.

J. Contrera, M. Goldstein, J. F. Contrera, 1961, Biochemical pharmacology.

Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part B. Use of (Q)SAR systems for early detection of drug-induced hepatobiliary and urinary tract toxicities.

Naomi L Kruhlak, R Daniel Benz, Gilles Klopman, 2009, Regulatory toxicology and pharmacology : RTP.