Xin Hu

发表

Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection

M. Ferrer, Noel Southall, Shanshan He, 2015, Science Translational Medicine.

Sunitinib promotes myogenic regeneration and mitigates disease progression in the mdx mouse model of Duchenne muscular dystrophy.

M. Ferrer, Noel Southall, Xin Hu, 2019, Human molecular genetics.

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

M. Ferrer, Xin Hu, J. Marugan, 2016, Nature Communications.

CERAPP: Collaborative Estrogen Receptor Activity Prediction Project

Ruili Huang, Igor V. Tetko, Eva Bay Wedebye, 2016, Environmental health perspectives.

Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors.

Xin Hu, Suneet Shukla, Damien Y. Duveau, 2013, Bioorganic & medicinal chemistry letters.

Proteolytic cleavage of host proteins by the Group IV viral proteases of Venezuelan equine encephalitis virus and Zika virus

Dagmar H. Leary, Xin Hu, J. Marugan, 2019, Antiviral research.

Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses

Jason B. White, M. Ferrer, Noel Southall, 2020, Science Translational Medicine.

First Emergence of acrAB and oqxAB Mediated Tigecycline Resistance in Clinical Isolates of Klebsiella pneumoniae Pre-Dating the Use of Tigecycline in a Chinese Hospital

Xin Hu, Haijian Zhou, Hong-tao Xu, 2014, PloS one.

Synthetic non‐peptide low molecular weight agonists of the relaxin receptor 1

Xin Hu, J. Marugan, I. Agoulnik, 2017, British journal of pharmacology.

Discovery and Characterization of a G Protein – Biased Agonist That Inhibits b-Arrestin Recruitment to the D 2 Dopamine Receptor s

M. Ferrer, D. Sibley, Noel Southall, 2014 .

Discovery and Characterization of a G Protein–Biased Agonist That Inhibits β-Arrestin Recruitment to the D2 Dopamine Receptor

M. Ferrer, D. Sibley, Noel Southall, 2014, Molecular Pharmacology.

Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry

Emily M. Lee, Hongjun Song, Ruili Huang, 2018, Cell Discovery.

Novel Cell-Based Hepatitis C Virus Infection Assay for Quantitative High-Throughput Screening of Anti-Hepatitis C Virus Compounds

Noel Southall, Shanshan He, Zongyi Hu, 2013, Antimicrobial Agents and Chemotherapy.

ehp CERAPP : Collaborative Estrogen Receptor Activity Prediction Project

Ruili Huang, Igor V. Tetko, Eva Bay Wedebye, 2016 .

Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK

C. Austin, Xin Hu, Wei Zheng, 2017, Autophagy.

Small Molecule, NSC95397, Inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression

M. Ferrer, Noel Southall, Xin Hu, 2015, Journal of biomolecular screening.

Quantum Dot-Conjugated SARS-CoV-2 Spike Pseudo-Virions Enable Tracking of Angiotensin Converting Enzyme 2 Binding and Endocytosis

Xin Hu, Miao Xu, Wei Zhu, 2020, ACS nano.

Non-covalent TMPRSS2 inhibitors identified from virtual screening.

A. Zakharov, P. Shinn, M. Hall, 2020, bioRxiv : the preprint server for biology.

A quinazoline‐based bromodomain inhibitor, CN210, ameliorates indomethacin‐induced ileitis in mice by inhibiting inflammatory cytokine expression

Xin Hu, M. Yoshioka, D. Maloney, 2021, Drug development research.

Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening

Catherine Z. Chen, P. Shinn, Xin Hu, 2020, bioRxiv.

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

Catherine Z. Chen, Ruili Huang, P. Shinn, 2021, Frontiers in Pharmacology.

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

Catherine Z. Chen, Ruili Huang, P. Shinn, 2020, bioRxiv.

A SIX1/EYA2 small molecule inhibitor disrupts EMT and metastasis.

M. Ferrer, H. Ford, J. Costello, 2020, Cancer research.

Targeting Estrogen Receptor Signaling with Fulvestrant Enhances Immune and Chemotherapy-Mediated Cytotoxicity of Human Lung Cancer

M. Ferrer, Noel Southall, Xin Hu, 2016, Clinical Cancer Research.

Identification of Selective CYP3A7 and CYP3A4 Substrates and Inhibitors Using a High-Throughput Screening Platform

Ruili Huang, M. Xia, S. Sakamuru, 2022, Frontiers in Pharmacology.

Lead optimization and efficacy evaluation of quinazoline-based BET family inhibitors for potential treatment of cancer and inflammatory diseases.

D. Urban, J. Strovel, A. Jadhav, 2019, Bioorganic & medicinal chemistry letters.

Discovery and lead identification of quinazoline-based BRD4 inhibitors.

D. Urban, J. Strovel, A. Jadhav, 2018, Bioorganic & medicinal chemistry letters.

Inhibitors of the Yersinia protein tyrosine phosphatase through high throughput and virtual screening approaches.

Noel Southall, Xin Hu, C. E. Stebbins, 2013, Bioorganic & medicinal chemistry letters.

Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models

M. Ferrer, Noel Southall, Xin Hu, 2020, Science Advances.

Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile.

Catherine Z. Chen, M. Ferrer, Noel Southall, 2018, European journal of medicinal chemistry.

Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.

A. Jadhav, M. Hall, A. Simeonov, 2018, Journal of medicinal chemistry.

Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis

M. Ferrer, C. Bishop, Noel Southall, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

SU9516 Increases α7β1 Integrin and Ameliorates Disease Progression in the mdx Mouse Model of Duchenne Muscular Dystrophy.

Catherine Z. Chen, M. Ferrer, Noel Southall, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

Identification of Small-Molecule Agonists of Human Relaxin Family Receptor 1 (RXFP1) by Using a Homogenous Cell-Based cAMP Assay

Raisa E Jones, Catherine Z. Chen, M. Ferrer, 2013, Journal of biomolecular screening.

Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease.

Michael S. Lee, Dagmar H. Leary, M. Ferrer, 2016, Biochemistry.

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

James B. Mitchell, D. Urban, W. Linehan, 2020, Cell reports.

Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection

Noel Southall, Wei Zheng, Xin Hu, 2015, Journal of medicinal chemistry.

Novel Cell-Based Hepatitis C Virus Infection Assay for Quantitative High-Throughput Screening of Anti-Hepatitis C Virus Compounds

Noel Southall, Shanshan He, Zongyi Hu, 2014, Antimicrobial Agents and Chemotherapy.

Discovery, Optimization and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist.

Ara M. Abramyan, M. Ferrer, D. Sibley, 2020, Journal of medicinal chemistry.

Discovery of TMPRSS2 Inhibitors from Virtual Screening as a Potential Treatment of COVID-19

Catherine Z. Chen, A. Zakharov, P. Shinn, 2021, ACS pharmacology & translational science.

Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle.

M. Ferrer, Noel Southall, Shanshan He, 2017, Journal of medicinal chemistry.

Identification of 4-phenylquinolin-2(1H)-one as a specific allosteric inhibitor of Akt

M. Ferrer, Noel Southall, Xin Hu, 2017, Scientific Reports.

Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2

M. Hall, A. Simeonov, Xin Hu, 2020, Trends in Pharmacological Sciences.

Allosteric Inhibitors of the Eya2 Phosphatase Are Selective and Inhibit Eya2-mediated Cell Migration*

M. Ferrer, H. Ford, E. Eisenmesser, 2014, The Journal of Biological Chemistry.

Identification of Chemotype Agonists for Human Resolvin D1 Receptor DRV1 with Pro-Resolving Functions.

M. Ferrer, Noel Southall, Xin Hu, 2019, Cell chemical biology.

[Clinical features of coronavirus disease 2019 in children aged <18 years in Jiangxi, China: an analysis of 23 cases].

Xin Hu, Xianheng Wu, F. Zhong, 2020, Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.

Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus

M. Ferrer, Noel Southall, Xin Hu, 2016, PLoS pathogens.

Discovery of TMPRSS2 inhibitors from virtual screening

Catherine Z. Chen, A. Zakharov, P. Shinn, 2020, bioRxiv.

The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules

Catherine Z. Chen, P. Shinn, M. Hall, 2020, ACS infectious diseases.

The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators

Catherine Z. Chen, P. Shinn, M. Hall, 2020, bioRxiv.

A high-throughput screening assay using Krabbe disease patient cells.

M. Ferrer, Noel Southall, Xin Hu, 2013, Analytical biochemistry.

Cell‐based high‐throughput screening identifies galactocerebrosidase enhancers as potential small‐molecule therapies for Krabbe's disease

M. Ferrer, Noel Southall, Xin Hu, 2016, Journal of neuroscience research.

Virtual Screening for the Discovery of Microbiome β-Glucuronidase Inhibitors to Alleviate Cancer Drug Toxicity

M. Hall, Hongmao Sun, Xin Hu, 2022, J. Chem. Inf. Model..

Mutation of Asn-475 in the Venezuelan Equine Encephalitis Virus nsP2 Cysteine Protease Leads to a Self-Inhibited State.

Xin Hu, J. Marugan, P. M. Legler, 2017, Biochemistry.

17-Hydroxy Wortmannin Restores TRAIL's Response by Ameliorating Increased Beclin 1 Level and Autophagy Function in TRAIL-Resistant Colon Cancer Cells

Xin Hu, Wei Zheng, B. Fang, 2019, Molecular Cancer Therapeutics.

Identification of Small Molecule Enhancers of Immunotherapy for Melanoma

M. Ferrer, Noel Southall, A. Jadhav, 2020, Scientific Reports.

Neuroprotective effect of the somatostatin receptor 5 agonist L-817,818 on retinal ganglion cells in experimental glaucoma.

Xin Hu, Zhongfeng Wang, Xinghuai Sun, 2021, Experimental eye research.

Optimization of ether and aniline based inhibitors of lactate dehydrogenase.

D. Urban, A. Jadhav, M. Hall, 2021, Bioorganic & medicinal chemistry letters.

Pyrazole-Based Lactate Dehydrogenase (LDH) Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.

D. Urban, A. Jadhav, C. Dang, 2020, Journal of medicinal chemistry.

Novel Patient Cell-Based HTS Assay for Identification of Small Molecules for a Lysosomal Storage Disease

M. Ferrer, Noel Southall, Xin Hu, 2011, PloS one.

Discovery, Optimization, and Characterization of Novel D2 Dopamine Receptor Selective Antagonists

Mercedes K. Taylor, M. Ferrer, D. Sibley, 2014, Journal of medicinal chemistry.

A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.

A. Zakharov, Adam Yasgar, A. Jadhav, 2021, Cell reports.

Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis

M. Ferrer, H. Ford, J. Costello, 2020, Cancer Research.

The SARS-CoV-2 SSHHPS Recognized by the Papain-like Protease

Katarina Z. Doctor, Dagmar H. Leary, Xin Hu, 2021, ACS infectious diseases.

Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods.

Xin Hu, P. M. Legler, J. Compton, 2019, Journal of visualized experiments : JoVE.

Disrupting malaria parasite AMA1 – RON2 interaction with a small molecule prevents erythrocyte invasion

Anton Simeonov, Xin Hu, Ajit Jadhav, 2013, Nature Communications.

Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1).

M. Ferrer, Adam Yasgar, A. Jadhav, 2015, Journal of medicinal chemistry.

DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation

M. Ferrer, Noel Southall, Xin Hu, 2018, Scientific Reports.

High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer

M. Ferrer, Noel Southall, Xin Hu, 2018, Scientific Reports.

Identification of Small-Molecule Inhibitors of Human Inositol Hexakisphosphate Kinases by High-Throughput Screening.

M. Ferrer, J. Barrow, Xin Hu, 2021, ACS pharmacology & translational science.

Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion

Noel Southall, Zongyi Hu, Xin Hu, 2020, Nature Microbiology.

Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion

Noel Southall, Zongyi Hu, Xin Hu, 2020, Nature microbiology.

Synaptamide activates the adhesion GPCR GPR110 (ADGRF1) through GAIN domain binding

Noel Southall, Xin Hu, J. Marugan, 2020, Communications Biology.

Hybrid In Silico Approach Reveals Novel Inhibitors of Multiple SARS-CoV-2 Variants

Catherine Z. Chen, A. Zakharov, M. Hall, 2021, bioRxiv.

Identification of Small Molecule Inhibitors of a Mir155 Transcriptional Reporter in Th17 Cells

M. Ferrer, Noel Southall, A. Jadhav, 2021, Scientific Reports.

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).

D. Urban, A. Jadhav, C. Dang, 2017, Journal of medicinal chemistry.

Physicochemical Characterization of a Thermostable Alcohol Dehydrogenase from Pyrobaculum aerophilum

Xin Hu, S. d'Auria, D. Auld, 2013, PloS one.

A large scale high-throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha[S]

M. Ferrer, Noel Southall, Xin Hu, 2019, Journal of Lipid Research.

CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity

Ruili Huang, Scott Boyer, Xin Hu, 2020, Environmental health perspectives.

Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1.

D. E. Anderson, Noel Southall, Zongyi Hu, 2020, Cell chemical biology.

An OpenData portal to share COVID-19 drug repurposing data in real time

Sam Michael, Paul Shinn, Ke Wang, 2020, bioRxiv.

A high-throughput screening to identify small molecules that suppress huntingtin promoter activity or activate huntingtin-antisense promoter activity

M. Ferrer, C. Ross, Noel Southall, 2021, Scientific Reports.

Discovery of a novel noniminosugar acid α glucosidase chaperone series.

M. Ferrer, Noel Southall, R. Tamargo, 2012, Journal of medicinal chemistry.

Identification of novel anti-hepatitis C virus agents by a quantitative high throughput screen in a cell-based infection assay.

M. Ferrer, Noel Southall, Shanshan He, 2015, Antiviral research.

Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening

Catherine Z. Chen, P. Shinn, Xin Hu, 2020, ACS pharmacology & translational science.

Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro

M. Ferrer, Noel Southall, Xin Hu, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening

Ajit Jadhav, Xin Hu, Noel Southall, 2014, Journal of Computer-Aided Molecular Design.

Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection

Emily M. Lee, Catherine Z. Chen, G. Ming, 2021, Bioorganic & Medicinal Chemistry Letters.

Structure-activity relationship studies and biological characterization of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.

Damien Y. Duveau, Adam Yasgar, A. Jadhav, 2014, Bioorganic & medicinal chemistry letters.

Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290

M. Ferrer, Noel Southall, Xin Hu, 2015, Front. Endocrinol..

Discovery of Small Molecule Entry Inhibitors Targeting the Fusion Peptide of SARS-CoV-2 Spike Protein

Catherine Z. Chen, P. Shinn, M. Hall, 2021, ACS medicinal chemistry letters.

SARS-CoV-2 omicron variants harbor spike protein mutations responsible for their attenuated fusogenic phenotype

Zongyi Hu, Xin Hu, T. Liang, 2023, Communications biology.

Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.

A. Jadhav, M. Hall, A. Simeonov, 2018, Journal of medicinal chemistry.

Discovery of novel inhibitors of human galactokinase by virtual screening

Ya-Qin Zhang, Min Shen, Xin Hu, 2019, Journal of Computer-Aided Molecular Design.

Structural Insights into the Activation of Human Relaxin Family Peptide Receptor 1 by Small-Molecule Agonists.

M. Ferrer, Noel Southall, Xin Hu, 2016, Biochemistry.

Mutant prevention concentration of tigecycline for Klebsiella pneumoniae isolates with four different resistance statuses.

Xin Hu, Hong-tao Xu, G. Cheng, 2015, Journal of infection in developing countries.

A SIX1/EYA2 small molecule inhibitor disrupts EMT and metastasis

M. Ferrer, H. Ford, J. Costello, 2020 .

Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes

Ruili Huang, A. Simeonov, Xin Hu, 2023, Nature communications.

Identification of Small Molecule Enhancers of Immunotherapy for Melanoma

M. Ferrer, Noel Southall, A. Jadhav, 2020, Scientific Reports.

High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors.

M. Ferrer, Noel Southall, Shanshan He, 2015, ACS combinatorial science.

Anxiolytic Drug FGIN-1-27 Ameliorates Autoimmunity by Metabolic Reprogramming of Pathogenic Th17 Cells

M. Ferrer, Noel Southall, A. Jadhav, 2020, Scientific Reports.

DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation

M. Ferrer, Noel Southall, Xin Hu, 2018, Scientific Reports.

In Silico Screening of Inhibitors of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease

Xin Hu, J. Marugan, Pamela J. Glass, 2023, Viruses.

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1

Raisa E Jones, Catherine Z. Chen, M. Ferrer, 2013, Nature Communications.

Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis

M. Ferrer, H. Ford, J. Costello, 2020, Cancer Research.

Cell‐based high‐throughput screening identifies galactocerebrosidase enhancers as potential small‐molecule therapies for Krabbe's disease

M. Ferrer, Noel Southall, Xin Hu, 2016, Journal of neuroscience research.

A high-throughput screening assay using Krabbe disease patient cells.

M. Ferrer, Noel Southall, Xin Hu, 2013, Analytical biochemistry.

Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease.

Michael S. Lee, Dagmar H. Leary, M. Ferrer, 2016, Biochemistry.

Hybrid In Silico Approach Reveals Novel Inhibitors of Multiple SARS-CoV-2 Variants

Catherine Z. Chen, A. Zakharov, M. Hall, 2021, ACS pharmacology & translational science.