Jingbo Xiao

发表

Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection

M. Ferrer, Noel Southall, Shanshan He, 2015, Science Translational Medicine.

Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted anti-oxidants.

C. Macias, P. Wipf, Jingbo Xiao, 2007, Biochemical pharmacology.

Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted antioxidants.

C. Macias, P. Wipf, Jingbo Xiao, 2007, Critical care medicine.

Discovery and Characterization of a G Protein – Biased Agonist That Inhibits b-Arrestin Recruitment to the D 2 Dopamine Receptor s

M. Ferrer, D. Sibley, Noel Southall, 2014 .

Discovery and Characterization of a G Protein–Biased Agonist That Inhibits β-Arrestin Recruitment to the D2 Dopamine Receptor

M. Ferrer, D. Sibley, Noel Southall, 2014, Molecular Pharmacology.

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Jingbo Xiao, J. Marugan, ossain, 2017, Scientific Reports.

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Jingbo Xiao, J. Marugan, R. Summers, 2017, Scientific Reports.

Mitochondrial targeting of selective electron scavengers: synthesis and biological analysis of hemigramicidin-TEMPO conjugates.

P. Wipf, Jingbo Xiao, M. Fink, 2005, Journal of the American Chemical Society.

Scheme 1, Synthetic route toward ML223

Juan J. Marugan, Noel Southall, Wei Zheng, 2013 .

Non-iminosugar glucocerebrosidase small molecule chaperones.

Noel Southall, A. Simeonov, Jingbo Xiao, 2012, MedChemComm.

Plasma and Tissue Concentrations of α-Tocopherol and δ-Tocopherol Following High Dose Dietary Supplementation in Mice

W. Pavan, Jingbo Xiao, Wei Zheng, 2012, Nutrients.

Discovery of a novel non-iminosugar acid alpha glucosidase chaperone series

Ellen, Noel Southall, R. Tamargo, 2012 .

Peptide-Like Molecules (PLMs): A Journey from Peptide Bond Isosteres to Gramicidin S Mimetics and Mitochondrial Targeting Agents.

P. Wipf, Jingbo Xiao, Corey R. J. Stephenson, 2009, Chimia.

ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice.

M. Ferrer, K. Fischbeck, E. Androphy, 2016, JCI insight.

Treatment With a Novel Hemigramicidin-TEMPO Conjugate Prolongs Survival in a Rat Model of Lethal Hemorrhagic Shock

C. Macias, P. Wipf, Jingbo Xiao, 2007, Annals of surgery.

Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile.

Catherine Z. Chen, M. Ferrer, Noel Southall, 2018, European journal of medicinal chemistry.

Identification of Small-Molecule Agonists of Human Relaxin Family Receptor 1 (RXFP1) by Using a Homogenous Cell-Based cAMP Assay

Raisa E Jones, Catherine Z. Chen, M. Ferrer, 2013, Journal of biomolecular screening.

Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection

Noel Southall, Wei Zheng, Xin Hu, 2015, Journal of medicinal chemistry.

Imine additions of internal alkynes for the synthesis of trisubstituted (E)-alkene and cyclopropane peptide isosteres

P. Wipf, Jingbo Xiao, Steven J. Geib, 2005 .

Studies on organophosphorus compounds 105: A facile synthesis of dialkyl 6‐substituted‐4‐hydroxy‐2‐trifluoromethylquinoline‐3‐phosphonates

Jingbo Xiao, Xiaomei Zhang, C. Yuan, 2000 .

Synthesis of trifluoromethyltetrazoles via building block strategy

Jingbo Xiao, De‐Xian Wang, Xiaomei Zhang, 1999 .

Electrostatic versus steric effects in peptidomimicry: synthesis and secondary structure analysis of gramicidin S analogues with (E)-alkene peptide isosteres.

P. Wipf, Jingbo Xiao, B. Weisblum, 2005, Journal of the American Chemical Society.

Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle.

M. Ferrer, Noel Southall, Shanshan He, 2017, Journal of medicinal chemistry.

Asymmetric Synthesis of Allenyl α-Amino Amides by an Isothiourea Catalyzed Enantioselective [2,3]-Sigmatropic Rearrangement.

Jingbo Xiao, Ling Zhang, Jin Song, 2018, Organic letters.

A facile asymmetric synthesis of 1-Amino-2,2,2-Trifluoroethanephosphonic acid

Jingbo Xiao, Xiaomei Zhang, C. Yuan, 2000 .

Asymmetric Synthesis of Aminophosphonic Acids and Trifluoromethylated Derivatives Thereof

Jingbo Xiao, Guoqiang Wang, C. Yuan, 2002 .

Discovery, synthesis, and biological evaluation of novel SMN protein modulators.

E. Androphy, Noel Southall, C. Austin, 2011, Journal of medicinal chemistry.

Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington’s disease

H. Vinters, J. Botas, Jingbo Xiao, 2014, Science Translational Medicine.

A new and facile stereocontrolled synthesis of conjugated dienyl trifluoromethyl ketones

Jingbo Xiao, C. Yuan, Yanshu Feng, 2000 .

Discovery, Optimization, and Characterization of Novel D2 Dopamine Receptor Selective Antagonists

Mercedes K. Taylor, M. Ferrer, D. Sibley, 2014, Journal of medicinal chemistry.

δ-Tocopherol Reduces Lipid Accumulation in Niemann-Pick Type C1 and Wolman Cholesterol Storage Disorders*

Christopher P Austin, Noel Southall, Wei Sun, 2012, The Journal of Biological Chemistry.

Convergent approach to (E)-alkene and cyclopropane peptide isosteres.

P. Wipf, Jingbo Xiao, 2005, Organic letters.

From natural products to biological tools

P. Wipf, Jingbo Xiao, T. Graham, 2007 .

Structural Requirements for Optimized Delivery, Inhibition of Oxidative Stress, and Antiapoptotic Activity of Targeted Nitroxides

P. Wipf, Jingbo Xiao, A. Studer, 2007, Journal of Pharmacology and Experimental Therapeutics.

Discovery of a novel noniminosugar acid α glucosidase chaperone series.

M. Ferrer, Noel Southall, R. Tamargo, 2012, Journal of medicinal chemistry.

ML223: A Small Molecule Probe With In Vivo Activity Against Acute Myeloid Leukemia Subtype M4Eo

Noel Southall, Jingbo Xiao, Wei Zheng, 2013 .

Identification of novel anti-hepatitis C virus agents by a quantitative high throughput screen in a cell-based infection assay.

M. Ferrer, Noel Southall, Shanshan He, 2015, Antiviral research.

Ideal and Reality: The Gap Between Evidence Derived From Randomized Controlled Trial-Based Meta-analysis and Real-World Clinical Practice in Antidepressant Strategy for Depression.

Jingbo Xiao, Lin Wang, Huaning Wang, 2020, Journal of clinical psychopharmacology.

Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290

M. Ferrer, Noel Southall, Xin Hu, 2015, Front. Endocrinol..

Discovery, optimization, and characterization of a novel series of dopamine D2 versus D3 receptor selective antagonists

Mercedes K. Taylor, M. Ferrer, D. Sibley, 2013 .

Trisubstituted (E)-alkene dipeptide isosteres as beta-turn promoters in the gramicidin S cyclodecapeptide scaffold.

P. Wipf, Jingbo Xiao, B. Weisblum, 2006, Organic letters.

Structural Insights into the Activation of Human Relaxin Family Peptide Receptor 1 by Small-Molecule Agonists.

M. Ferrer, Noel Southall, Xin Hu, 2016, Biochemistry.

Use of transcriptional synergy to augment sensitivity of a splicing reporter assay.

P. Wipf, Jingbo Xiao, Ashwini Patil, 2006, RNA.

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1

Raisa E Jones, Catherine Z. Chen, M. Ferrer, 2013, Nature Communications.

Table 1, Screen Quest™ Fluor-8 of D2 Ca2+ qHTS assay protocol

Steve Titus, Juan J. Marugan, Noel Southall, 2013 .

δ-Tocopherol Reduces Lipid Accumulation in Niemann-Pick Type C1 and Wolman Cholesterol Storage Disorders*

U. Baxa, W. Pavan, Noel Southall, 2012, Journal of Biological Chemistry.