Cheng-Chang Chen

发表

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

Y. Sakurai, A. Kolokoltsov, Cheng-Chang Chen, 2015, Science.

TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms

C. Berking, A. Vollmar, Cheng-Chang Chen, 2017, Proceedings of the National Academy of Sciences.

Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells

Cheng-Chang Chen, C. Grimm, C. Wahl-Schott, 2015, The EMBO journal.

Cellular Zinc Levels Are Modulated by TRPML1–TMEM163 Interaction

Cheng-Chang Chen, C. Grimm, M. Biel, 2014, Traffic.

Regulation of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Activity by cCMP*

Cheng-Chang Chen, C. Wahl-Schott, M. Biel, 2012, The Journal of Biological Chemistry.

A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV

R. Schiffmann, Cheng-Chang Chen, C. Grimm, 2014, Nature Communications.

Electrophysiology of Endolysosomal Two-Pore Channels: A Current Account

Cheng-Chang Chen, C. Grimm, Taufiq Rahman, 2022, Cells.

Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3.

Cheng-Chang Chen, C. Grimm, M. Schaefer, 2020, European journal of medicinal chemistry.

Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2

A. Vollmar, K. Umehara, Cheng-Chang Chen, 2021, Scientific Reports.

Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells

A. Vollmar, Cheng-Chang Chen, C. Grimm, 2018, eLife.

Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice

T. Gudermann, Cheng-Chang Chen, C. Grimm, 2022, Nature Communications.

ORF8a of SARS-CoV forms an ion channel: Experiments and molecular dynamics simulations

Cheng-Chang Chen, P. Henklein, W. Fischer, 2010, Biochimica et Biophysica Acta (BBA) - Biomembranes.

Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

Meghan T. Miller, T. Gudermann, A. Vollmar, 2020, eLife.

Small Molecules for Early Endosome-Specific Patch Clamping.

S. Heller, Cheng-Chang Chen, C. Grimm, 2017, Cell chemical biology.

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

M. Mann, O. Griesbeck, Cheng-Chang Chen, 2014, Nature Communications.

TRPML Cation Channels in Inflammation and Immunity

Cheng-Chang Chen, C. Grimm, Yu-Kai Chao, 2020, Frontiers in Immunology.

Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth.

S. Zahler, A. Vollmar, Cheng-Chang Chen, 2021, Cell chemical biology.

From mucolipidosis type IV to Ebola: TRPML and two-pore channels at the crossroads of endo-lysosomal trafficking and disease.

Cheng-Chang Chen, C. Grimm, C. Wahl-Schott, 2017, Cell calcium.

Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function

Cheng-Chang Chen, C. Grimm, C. Wahl-Schott, 2017, Front. Pharmacol..

Recombinant tandem of pore-domains in a Weakly Inward rectifying K+ channel 2 (TWIK2) forms active lysosomal channels

Cheng-Chang Chen, C. Grimm, C. Wahl-Schott, 2017, Scientific Reports.

Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice

T. Gudermann, Cheng-Chang Chen, C. Grimm, 2022, Nature Communications.

TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration

Cheng-Chang Chen, N. Klugbauer, C. Grimm, 2021, Life Science Alliance.

Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes

Cheng-Chang Chen, C. Grimm, C. Wahl-Schott, 2017, Nature Protocols.

Endolysosomal cation channels point the way towards precision medicine of cancer and infectious diseases.

Cheng-Chang Chen, M. Biel, Sui‐Yuan Chang, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-action.

Cheng-Chang Chen, S. Pillai, J. Guatelli, 2011, Virology.

Two-pore and TRP cation channels in endolysosomal osmo-/mechanosensation and volume regulation.

Cheng-Chang Chen, C. Grimm, Einar K Krogsaeter, 2020, Biochimica et biophysica acta. Molecular cell research.

TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular AMD

C. Grimm, Cheng-Chang Chen, N. Klugbauer, 2021 .

TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles

Cheng-Chang Chen, C. Grimm, C. Wahl-Schott, 2020, Science Advances.

Truncation of GalNAc-type O-glycans Suppresses CD44-mediated Osteoclastogenesis and Bone Metastasis in Breast Cancer

Cheng-Chang Chen, N. Lin, Syue-Ting Chen, 2023, Molecular cancer research : MCR.

BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-action.

Cheng-Chang Chen, S. Pillai, J. Guatelli, 2011, Virology.

Recombinant tandem of pore-domains in a Weakly Inward rectifying K+ channel 2 (TWIK2) forms active lysosomal channels

Cheng-Chang Chen, C. Grimm, C. Wahl-Schott, 2017, Scientific Reports.