I. Awad

I. Awad, D. Wecht, S. Berger, 1998, Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences.

Recommendations for the Management of Patients With Unruptured Intracranial Aneurysms: A Statement for Healthcare Professionals From the Stroke Council of the American Heart Association

C Caroselli, T Brott, D. Wiebers, 2000, Stroke.

Recommendations for the management of patients with unruptured intracranial aneurysms: A statement for healthcare professionals from the Stroke Council of the American Heart Association.

C Caroselli, T Brott, D. Wiebers, 2000, Circulation.

Misdiagnosis of symptomatic cerebral aneurysm. Prevalence and correlation with outcome at four institutions.

I. Awad, R. Harbaugh, L. Hopkins, 1996, Stroke.

Guidelines for the Prevention of Stroke in Women: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association

Gustavo Saposnik, Viola Vaccarino, Louise D McCullough, 2014, Stroke.

The effect of propofol on the electroencephalogram of patients with epilepsy.

I. Awad, A. Schubert, B. Wolgamuth, 1994 .

Functional anatomy of the human supplementary sensorimotor area: results of extraoperative electrical stimulation.

E Wyllie, H H Morris, G. Klem, 1994, Electroencephalography and clinical neurophysiology.

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signaling

Zinan Zhou, Dean Y. Li, R. Shenkar, 2016, Nature.

CONCEPTS AND HYPOTHESES: INFLAMMATORY HYPOTHESIS IN THE PATHOGENESIS OF CEREBRAL CAVERNOUS MALFORMATIONS

Issam A Awad, R. Shenkar, I. Awad, 2007, Neurosurgery.

Comparative localization of auditory comprehension by using functional magnetic resonance imaging and cortical stimulation.

G McCarthy, M Luby, G. McCarthy, 1999, Journal of neurosurgery.

Recommendations for the management of intracranial arteriovenous malformations: a statement for healthcare professionals from a special writing group of the Stroke Council, American Stroke Association.

D. Kondziolka, P. Stieg, W. Young, 2001, Circulation.

Reporting terminology for brain arteriovenous malformation clinical and radiographic features for use in clinical trials.

J Pile-Spellman, R F Spetzler, A M Malek, 2001, Stroke.

Intracranial Hypertension After Resection of Cerebral Arteriovenous Malformations: Predisposing Factors and Management Strategy

I. Awad, A. Schubert, M. Magdinec, 1994, Stroke.

Detection of microbleeds associated with sentinel headache using MRI quantitative susceptibility mapping: pilot study.

J. Greenlee, V. Magnotta, J. Torner, 2019, Journal of neurosurgery.

The cerebral cavernous malformation disease causing gene KRIT1 participates in intestinal epithelial barrier maintenance and regulation

I. Awad, T. He, S. Polster, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Current Concepts of Cerebrovascular Disease and Stroke Periventricular Lesions on MRI Facts and Theories

I. Awad, A. Furlan, M. Chimowitz, 2005 .

Failure of the hypotensive provocative test during temporary balloon test occlusion of the internal carotid artery to predict delayed hemodynamic ischemia after therapeutic carotid occlusion.

I. Awad, C. Putman, P. Fayad, 1998, Surgical neurology.

Hemorrhagic stroke: introduction.

D. Hanley, P. Vespa, I. Awad, 2013, Stroke.

Decision Making for Minimally Invasive Spine Surgery

I. Awad, R. Fessler, J. Voyadzis, 2011 .

Toward more rational prediction of outcome in patients with high-grade subarachnoid hemorrhage.

I. Awad, E. Claus, V. Chiang, 2000, Neurosurgery.

Stereotactic laser interstitial thermal therapy for epilepsy associated with solitary and multiple cerebral cavernous malformations.

N. Issa, I. Awad, James Tao, 2020, Neurosurgical focus.

Neuroendovascular Interventions for Intracranial Posterior Circulation Disease via the Transradial Approach: Technical Case Report

I. Awad, B. Bendok, H. Batjer, 2005, Neurosurgery.

Phenotypic Characterization of Murine Models of Cerebral Cavernous Malformations

R. Shenkar, I. Awad, Ying Cao, 2017, Laboratory Investigation.

Clinical Usefulness of Magnetic Resonance Angiography in Neurosurgical Practice

I. Awad, T. Masaryk, M. Magdinec, 1994 .

The Modified Graeb Score: An Enhanced Tool for Intraventricular Hemorrhage Measurement and Prediction of Functional Outcome

D. Hanley, I. Awad, W. Ziai, 2013, Stroke.

What Is the Best Medical Treatment for Symptomatic Intracranial Stenosis

I. Awad, F. Albuquerque, 2012 .

AHA Scientific Statement: Recommendations for the management of intracranial arteriovenous malformations: a statement for healthcare professionals from a special writing group of the Stroke Council, American Stroke Association.

D. Kondziolka, P. Stieg, W. Young, 2001, Stroke.

Surgical Trials in Intracerebral Hemorrhage

D. Hanley, P. Vespa, I. Awad, 2013, Stroke.

Pathophysiology of Intracerebral Hemorrhage Surgery for Ich Minimally Invasive Neurosurgery for Hemorrhage Evacuation Surgical Trials in Intracerebral Hemorrhage Hemorrhagic Stroke

D. Hanley, P. Vespa, I. Awad, 2022 .

Patch angioplasty in carotid endarterectomy. Advantages, concerns, and controversies.

I. Awad, J. Little, 1989, Stroke.

Venous Thromboembolism After Intraventricular Hemorrhage: Results From the CLEAR III Trial

D. Hanley, I. Awad, W. Ziai, 2019, Neurosurgery.

Unmet Needs and Challenges in Clinical Research of Intracerebral Hemorrhage.

T. Louis, C. Anderson, D. Hanley, 2018, Stroke.

Surgery for intracerebral hemorrhage

I. Awad, P. Fayad, 1998, Neurology.

Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease

Courtney P Orsbon, R. Shenkar, I. Awad, 2016, Journal of Neuroscience Methods.

Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations

D. Kleinfeld, I. Awad, Thomas Moore, 2020, bioRxiv.

Protocols and critical pathways for stroke care.

I. Awad, P. Fayad, S. Abdulrauf, 1999, Clinical neurosurgery.

African American Screening and Enrollment in (Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage III) CLEAR III.

Richard E Thompson, D. Hanley, I. Awad, 2018, Clinical researcher.

Neurological deterioration in a patient with a spinal arteriovenous malformation following lumbar puncture. Case report.

G. Barnett, I. Awad, 1990, Journal of neurosurgery.

Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice.

I. Awad, C. Esmon, S. Polster, 2019, Blood.

Phantom validation of quantitative susceptibility and dynamic contrast‐enhanced permeability MR sequences across instruments and sites

Xiaohong Joe Zhou, T. Parrish, R. Shenkar, 2020, Journal of magnetic resonance imaging : JMRI.

Trial Readiness in Cavernous Angiomas With Symptomatic Hemorrhage (CASH)

Richard E Thompson, L. Morrison, D. Hanley, 2019, Neurosurgery.

ADVANCED MAGNETIC RESONANCE IMAGING OF CEREBRAL CAVERNOUS MALFORMATIONS: PART I. HIGH‐FIELD IMAGING OF EXCISED HUMAN LESIONS

R. Shenkar, I. Awad, A. Wyrwicz, 2008, Neurosurgery.

Fasudil Decreases Lesion Burden in a Murine Model of Cerebral Cavernous Malformation Disease

R. Shenkar, I. Awad, D. Marchuk, 2012, Stroke.

Cerebral cavernous malformations as a disease of vascular permeability: from bench to bedside with caution.

R. Shenkar, I. Awad, P. Jabbour, 2010, Neurosurgical focus.

A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.

R. Kucherlapati, R. Shenkar, I. Awad, 2011, Human molecular genetics.

BRAINSTEM CAVERNOUS MALFORMATIONS

I. Awad, B. Bendok, B. Gross, 2009, Neurosurgery.

How frequently should we follow small asymptomatic intracranial aneurysms?

I. Awad, B. Bendok, H. Batjer, 2006, Stroke.

Intraventricular Hemorrhage Expansion in the CLEAR III Trial: A Post Hoc Exploratory Analysis

D. Hanley, I. Awad, W. Ziai, 2022, Stroke.

Permanent CSF shunting after intraventricular hemorrhage in the CLEAR III trial

D. Hanley, I. Awad, W. Ziai, 2017, Neurology.

Resolution of Intraventricular Hemorrhage Varies by Ventricular Region and Dose of Intraventricular Thrombolytic: The Clot Lysis Evaluating Accelerated Resolution of IVH (CLEAR IVH) Program

D. Hanley, J. Muschelli, I. Awad, 2012, Stroke.

Second operation after the failure of previous resection for epilepsy.

H. Lüders, I. Awad, M. Nayel, 1991, Neurosurgery.

Circulating Plasma miRNA Homologs in Mice and Humans Reflect Familial Cerebral Cavernous Malformation Disease

R. Shenkar, I. Awad, Bingqing Xie, 2022, Translational Stroke Research.

Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation.

R. Shenkar, I. Awad, Ch Lai, 2021, The Journal of clinical investigation.

Non cell-autonomous effect of astrocytes on cerebral cavernous malformations

R. Shenkar, I. Awad, Ch Lai, 2021, bioRxiv.

A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis

A. Fraser, A. Gingras, I. Awad, 2019, Nature Communications.

Quantitative Analysis of Seizure Frequency 1 Week and 6, 12, and 24 Months After Surgery of Epilepsy

H. Lüders, D. Dinner, I. Awad, 1994, Epilepsia.

Natural History of Recurrent Seizures After Resective Surgery for Epilepsy

H. Lüders, I. Awad, E. Wingkun, 1991, Epilepsia.

A new class of electrodes of 'intermediate invasiveness': preliminary experience with epidural pegs and foramen ovale electrodes in the mapping of seizure foci.

R. Burgess, G. Barnett, I. Awad, 1991, Neurological research.

Prediction of cognitive change as a function of preoperative ability status among temporal lobectomy patients seen at 6‐month follow‐up

H. Lüders, G. Chelune, I. Awad, 1991, Neurology.

When does temporal lobe resection improve or impair cognitive ability

H. Lüders, G. Chelune, I. Awad, 1990 .

Second Operation after the Failure of Previous Resection for Epilepsy

H. Lüders, I. Awad, M. Nayel, 1991 .

Extent of mesiobasal resection determines outcome after temporal lobectomy for intractable complex partial seizures.

I. Awad, H. Luders, M. Nayel, 1991, Neurosurgery.

MRI-guided stereotactic placement of depth electrodes in temporal lobe epilepsy.

P. Pillay, G. Barnett, I. Awad, 1992, British journal of neurosurgery.

Epilepsy surgery in children and adults.

I. Awad, H. Luders, S. Lim, 1993, Annals of the Academy of Medicine, Singapore.

Intracarotid Amobarbital Procedure: I. Prediction of Decreased Modality‐Specific Memory Scores After Temporal Lobectomy

H. Lüders, G. Chelune, I. Awad, 1991, Epilepsia.

Quantification of temporal lobe resections: a new approach.

H. Lüders, I. Awad, A. Katz, 1989, Cleveland Clinic journal of medicine.

Intracarotid Amobarbital Procedure as a Predictor of Material‐Specific Memory Change After Anterior Temporal Lobectomy

G. Chelune, I. Awad, R. Naugle, 1995, Epilepsia.

Endovascular therapeutic approach to peripheral aneurysms of the superior cerebellar artery.

I. Awad, C. Putman, C. Putman, 1996, AJNR. American journal of neuroradiology.

Application of magnetic resonance angiography to neurosurgical practice: a critical review of 150 cases.

I. Awad, M. Magdinec, T. Masaryk, 1992, Neurological research.

Biomarkers of cavernous angioma with symptomatic hemorrhage.

R. Shenkar, I. Awad, Agnieszka Stadnik, 2019, JCI insight.

Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation

I. Awad, S. Polster, C. Weber, 2020, International journal of molecular sciences.

Treatment of acute focal cerebral ischemia with prostacyclin.

R. Lesser, I. Awad, R. Slugg, 1983, Stroke.

A Scientific Statement for Healthcare Professionals From the Stroke Coronary Risk Evaluation in Patients With Transient Ischemic Attack and Ischemic

J. Alpert, R. Adams, I. Awad, 2022 .

Plasma Biomarkers of Inflammation Reflect Seizures and Hemorrhagic Activity of Cerebral Cavernous Malformations

Dean Y. Li, R. Shenkar, I. Awad, 2018, Translational Stroke Research.

Modification of focal cerebral ischemia by prostacyclin and indomethacin.

R. Lesser, I. Awad, R. Slugg, 1983, Journal of neurosurgery.

Treatment of Focal Cerebral Ischemia with Prostacyclin and Indomethacin

R. Lesser, I. Awad, R. Slugg, 1984 .

Leptomeningeal metastasis from supratentorial malignant gliomas.

I. Awad, L. Rogers, J. Bay, 1986, Neurosurgery.

Association of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis

A. Alexandrov, O. Witte, M. Endres, 2022, Stroke.

Neonatal galenic arteriovenous malformation.

I. Awad, R. Spetzler, A. Berenstein, 1999, Neurosurgery.

One-Year Outcome Trajectories and Factors Associated with Functional Recovery Among Survivors of Intracerebral and Intraventricular Hemorrhage With Initial Severe Disability.

D. Hanley, I. Awad, W. Ziai, 2022, JAMA neurology.

Surgical management of syringomyelia: a five year experience in the era of magnetic resonance imaging.

J. Hahn, P. Pillay, I. Awad, 1991, Neurological research.

Occipital lobe vascular malformations: prevalence of visual field deficits and prognosis after therapeutic intervention.

I. Awad, D. Wecht, P. Fayad, 1998, Neurosurgery.

Bleeding and infection with external ventricular drainage: a systematic review in comparison with adjudicated adverse events in the ongoing Clot Lysis Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III (CLEAR-III IHV) trial.

D. Hanley, C. Kase, I. Awad, 2015, Neurosurgery.

Intraoperative endovascular treatment as an adjunct to microsurgical clipping of paraclinoid aneurysms.

I. Awad, M. Gunel, D. Huddle, 2000, Journal of neurosurgery.

Quantitative Susceptibility Mapping in Cerebral Cavernous Malformations: Clinical Correlations

R R Edelman, Y Wang, R. Edelman, 2016, American Journal of Neuroradiology.

EXCEPTIONAL AGGRESSIVENESS OF CEREBRAL CAVERNOUS MALFORMATION DISEASE ASSOCIATED WITH PDCD10 MUTATIONS

W. Min, R. Shenkar, I. Awad, 2014, Genetics in Medicine.

Mapping a gene causing cerebral cavernous malformation to 7q11.2-q21.

I. Awad, R. Lifton, M. Günel, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Rapamycin in Cerebral Cavernous Malformations: What Doses to Test in Mice and Humans.

R. Shenkar, I. Awad, Agnieszka Stadnik, 2022, ACS pharmacology & translational science.

Comparison of the clinical presentation of symptomatic arteriovenous malformations (angiographically visualized) and occult vascular malformations.

I. Awad, J. R. Robinson, 1993, Neurosurgery.

Intensive care after elective craniotomy: "all politics is local".

I. Awad, 2014, World neurosurgery.

Chapter 44 – Overview

I. Awad, K. Vives, 1999 .

Recombinant Human Coagulation Factor VIIa for Intracerebral Hemorrhage.

I. Awad, J. Cozzens, 2006, Neurosurgery.

Emerging clinical imaging techniques for cerebral cavernous malformations: a systematic review.

I. Awad, P. Jabbour, P. Campbell, 2010, Neurosurgical focus.

Cavernous malformations.

I. Awad, 2012, Journal of neurosurgery.

Mixed vascular malformations of the brain: clinical and pathogenetic considerations.

I. Awad, M. Estes, J. R. Robinson, 1993, Neurosurgery.

CSF and serum inflammatory response and association with outcomes in spontaneous intracerebral hemorrhage with intraventricular extension: an analysis of the CLEAR-III Trial

D. Hanley, I. Awad, C. Thompson, 2021, Journal of Neuroinflammation.

A “pseudo-cavernoma” – An encapsulated hematoma of the choroid plexus

I. Awad, P. Pytel, M. Dey, 2011, Journal of Clinical Neuroscience.

Intraventricular Hemorrhage Secondary to Intranidal Aneurysm Rupture—Successful Management by Arteriovenous Malformation Embolization Followed by Intraventricular Tissue Plasminogen Activator: Case Report

I. Awad, B. Bendok, A. Shaibani, 2011, Neurosurgery.

Open Evacuation of Intracerebral Hematoma

I. Awad, J. Jaffe, M. Dey, 2020, Core Techniques in Operative Neurosurgery.

Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican

W. Min, R. Shenkar, I. Awad, 2020, The Journal of experimental medicine.

Occipital Lobe Vascular Malformations: Prevalence of Visual Field Deficits and Prognosis after Therapeutic Intervention

I. Awad, D. Wecht, P. Fayad, 1998 .

Extracranial-intracranial bypass surgery: a critical analysis in light of the International Cooperative Study.

I. Awad, R. Spetzler, 1986, Neurosurgery.

Experimental limbic epilepsy: models, pathophysiologic concepts, and clinical relevance.

H. Lüders, I. Awad, M. Larkins, 1991, Cleveland Clinic journal of medicine.

Low-Dose Recombinant Tissue-Type Plasminogen Activator Enhances Clot Resolution in Brain Hemorrhage: The Intraventricular Hemorrhage Thrombolysis Trial

S. Mayer, D. Hanley, A. Marmarou, 2011, Stroke.

The Incidence of Catheter Tract Hemorrhage and Catheter Placement Accuracy in the CLEAR III Trial

Richard E Thompson, D. Hanley, I. Awad, 2018, Neurocritical Care.

Not “doing the same thing over and over again”

D. Hanley, I. Awad, W. Ziai, 2018 .

Spontaneous angiographic obliteration of cerebral arteriovenous malformations.

I. Awad, G. Malik, S. Abdulrauf, 1999, Neurosurgery.

Propranolol as therapy for cerebral cavernous malformations: a cautionary note

R. Shenkar, I. Awad, D. Marchuk, 2022, Journal of translational medicine.

Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism in animal models.

R. Shenkar, I. Awad, Ying Cao, 2021, The Journal of clinical investigation.

Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism.

R. Shenkar, I. Awad, Ying Cao, 2020, The Journal of clinical investigation.

In Reply: Intracerebral Hemorrhage Volume Reduction and Timing of Intervention Versus Functional Benefit and Survival in the MISTIE III and STICH Trials.

I. Awad, S. Polster, 2021, Neurosurgery.

Pathology and Genetic Factors

I. Awad, J. Wong, R. Moussa, 2006 .

Drainage Efficiency with Dual Versus Single Catheters in Severe Intraventricular Hemorrhage

D. Hanley, J. Muschelli, I. Awad, 2012, Neurocritical Care.

Further Study of CD31 Protein and Messenger Ribonucleic Acid Expression in Human Cerebral Vascular Malformations

Nabil A Awadallah, I. Awad, O. Ogunshola, 2002, Neurosurgery.

Surgical Econometrics: A New Science?

I. Awad, 2006, Neurosurgery.

Traumatic postsurgical aneurysm of the intracavernous carotid artery: a delayed presentation.

I. Awad, J. Little, B. Sawhny, 1982, Surgical neurology.

Ipsilateral leg weakness associated with carotid stenosis.

I. Awad, A. Furlan, M. Chimowitz, 1990, Stroke.

Retrograde suction decompression of giant paraclinoid aneurysms using a No. 7 French balloon-containing guide catheter. Technical note.

I. Awad, B. Bendok, A. Shaibani, 2006, Journal of neurosurgery.

Intracranial dural arteriovenous malformations: factors predisposing to an aggressive neurological course.

I. Awad, J. Little, J. Ahl, 1990, Journal of neurosurgery.

Patients with cranial dural arteriovenous fistulas may benefit from expanded hypercoagulability and cancer screening.

I. Awad, S. Polster, H. Zeineddine, 2017, Journal of neurosurgery.

‘Standards and guidelines for standards and guidelines’: intracranial dural arteriovenous shunts as a paradigm

I. Awad, 2016, Journal of NeuroInterventional Surgery.

68 – Dural Arteriovenous Malformations

I. Awad, J. K. Eliyas, 2016 .

65 – Dural Arteriovenous Malformations

I. Awad, D. Huddle, J. Elliott, 2011 .

Paradoxical clinicoradiologic features of a cavernous dural arteriovenous malformation

I. Awad, C. Putman, J. Chaloupka, 1997, Journal of Clinical Neuroscience.

Molecular Biology of Arteriovenous Malformations

I. Awad, M. Gunel, T. KiliÇ, 2006 .

Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis.

D. Corcoran, R. Shenkar, I. Awad, 2014, Human molecular genetics.

Open Research Online Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice

I. Awad, C. Esmon, R. Girard, 2022 .

PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism

M. Lawton, R. Shenkar, I. Awad, 2021, Nature.

A Roadmap for Developing Plasma Diagnostic and Prognostic Biomarkers of Cerebral Cavernous Angioma With Symptomatic Hemorrhage (CASH).

S. Greenberg, R. Shenkar, I. Awad, 2021, Neurosurgery.

Subclinical imaging changes in cerebral cavernous angiomas during prospective surveillance.

R. Shenkar, I. Awad, Agnieszka Stadnik, 2020, Journal of neurosurgery.

A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease

R. Shenkar, I. Awad, Ying Cao, 2019, Translational Stroke Research.

Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes.

R. Shenkar, I. Awad, Ying Cao, 2019, JCI insight.

The Pipeline Embolization Device: Beyond the Approved Indication

I. Awad, F. Albuquerque, 2014 .

Cerebral cavernous malformations: clinical insights from genetic studies.

R. Shenkar, I. Awad, B. Bendok, 2006, Neurosurgical focus.

Changes in intracranial stenotic lesions after extracranial-intracranial bypass surgery.

I. Awad, A. Furlan, J. Little, 1984, Journal of neurosurgery.

Microvascular decompression of cranial nerves using sheets of a dural substitute. Commentary

I. Awad, T. Itakura, K. Nakai, 2004 .

Coronary risk evaluation in patients with transient ischemic attack and ischemic stroke: a scientific statement for healthcare professionals from the Stroke Council and the Council on Clinical Cardiology of the American Heart Association/American Stroke Association.

J. Alpert, R. Adams, I. Awad, 2003, Stroke.

Evidence-based interconversion of the Glasgow Outcome and modified Rankin scales: pitfalls and best practices.

S. Blackburn, D. Hanley, I. Awad, 2022, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

Carotid Cavernous and Other Dural Arteriovenous Fistulas

I. Awad, D. Wecht, 1997 .

Image-Guided Catheter Evacuation and Thrombolysis for Intracerebral Hematoma

I. Awad, J. Jaffe, M. Dey, 2020, Core Techniques in Operative Neurosurgery.

Current management of cerebral aneurysms

I. Awad, 1993 .

Gardner's hydrodynamic theory of syringomyelia revisited.

J. Hahn, P. Pillay, I. Awad, 1992, Cleveland Clinic journal of medicine.

Intracranial meningiomas in the aged: surgical outcome in the era of computed tomography.

J. Hahn, I. Awad, J. Little, 1989, Neurosurgery.

Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot trial

N. Bresolin, V. Torri, R. Pallini, 2022, The Lancet Neurology.

S timulating S cience in a U nique S etting S timulating S cience in a

I. Awad, R. Dempsey, H. Brem, 2006 .

Oligoclonal immune response in cerebral cavernous malformations. Laboratory investigation.

R. Shenkar, I. Awad, Changbin Shi, 2007, Journal of neurosurgery.

Abstracts Presented at the Neurocritical Care Society (NCS) 15th Annual Meeting

Zuccarello, I. Awad, Nichol McBee, 2017, Neurocritical Care.

Commentary: Feasibility and Morbidity of Magnetic Resonance Imaging-Guided Stereotactic Laser Ablation of Deep Cerebral Cavernous Malformations: A Report of 4 Cases.

I. Awad, 2021, Neurosurgery.

Risks of Surgical Management for Cavernous Malformations of the Nervous System

I. Awad, S. Abdulrauf, 1998 .

Ischemic stroke and intracranial multifocal cerebral arteriopathy in Williams syndrome.

B. Shaywitz, I. Awad, P. Fayad, 1995, The Journal of pediatrics.

Neurological Surgery: A Comprehensive Reference Guide to the Diagnosis and Management of Neurosurgical Problems

W. B. Saunders, I. Awad, Issam A. Awad, 1990 .

Vascular Malformations and Epilepsy: Clinical Considerations and Basic Mechanisms

I. Awad, D. Kraemer, 1994, Epilepsia.

Intracranial cavernous malformations: lesion behavior and management strategies.

I. Awad, J. N. Maraire, 1995, Neurosurgery.

Surgical Cavernous Malformations and Venous Anomalies

I. Awad, B. Bendok, J. Chandler, 2015 .

Advances in open neurovascular surgery 2007.

I. Awad, B. Bendok, B. Gross, 2009, Stroke.

Impact of Guglielmi detachable coils on outcomes of patients with intracranial aneurysms treated by a multidisciplinary team at a single institution.

I. Awad, J. Rinne, Zhenqiu Lin, 2000, Journal of neurosurgery.

Brainstem cavernous malformations: 1390 surgical cases from the literature.

I. Awad, R. Du, B. Bendok, 2013, World neurosurgery.

Natural history of the cavernous angioma.

John R. Robinson, I. Awad, J. Little, 1991, Journal of neurosurgery.

Novel Murine Models of Cerebral Cavernous Malformations

R. Shenkar, I. Awad, Ying Cao, 2020, Angiogenesis.

Mutational analysis of 206 families with cavernous malformations.

Johnson, K., Faheem Niazi, 2003, Journal of neurosurgery.

Patch Angioplasty in Carotid Endarterectomy

I. Awad, J. Little, 2005 .

Phases of Healing of Endarterectomized Endarterectomized artery Artery and of Patch Grafts Autologous vein patch Patch grafts Preclotted Dacron Processed bovine pericardium I

I. Awad, John, Little, 2005 .

Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial

D. Hanley, J. Muschelli, P. Vespa, 2017, The Lancet.

Clinical vasospasm after subarachnoid hemorrhage: response to hypervolemic hemodilution and arterial hypertension.

I. Awad, R. Spetzler, L. Carter, 1987, Stroke.

SPECTRUM OF GENOTYPE AND CLINICAL MANIFESTATIONS IN CEREBRAL CAVERNOUS MALFORMATIONS

S. Sain, J. Gault, I. Awad, 2006, Neurosurgery.

Differential Gene Expression in Human Cerebrovascular Malformations

Issam A Awad, Judith Gault, Tzulip Phang, 2003, Neurosurgery.

β1 integrin monoclonal antibody treatment ameliorates cerebral cavernous malformations

R. Shenkar, I. Awad, Thomas Moore, 2022, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Developmental venous anomalies are a genetic primer for cerebral cavernous malformations

I. Awad, D. Marchuk, R. Girard, 2021, Nature Cardiovascular Research.

Perfusion and permeability as diagnostic biomarkers of cavernous angioma with symptomatic hemorrhage

R. Shenkar, I. Awad, Agnieszka Stadnik, 2021, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma

L. Morrison, R. Shenkar, I. Awad, 2020, Nature Communications.

Novel hemorrhage models of cerebral cavernous malformations

R. Shenkar, I. Awad, Ying Cao, 2020, bioRxiv.

Cavernous angiomas: deconstructing a neurosurgical disease.

I. Awad, S. Polster, 2019, Journal of neurosurgery.

Immune complex formation and in situ B-cell clonal expansion in human cerebral cavernous malformations

R. Shenkar, I. Awad, A. Kinloch, 2014, Journal of Neuroimmunology.

A founder mutation in the Ashkenazi Jewish population affecting messenger RNA splicing of the CCM2 gene causes cerebral cavernous malformations

J. Weber, I. Awad, D. Marchuk, 2011, Genetics in Medicine.

CEREBRAL CAVERNOUS MALFORMATIONS: SOMATIC MUTATIONS IN VASCULAR ENDOTHELIAL CELLS

J. Gault, R. Shenkar, I. Awad, 2009, Neurosurgery.

Different spectra of genomic deletions within the CCM genes between Italian and American CCM patient cohorts

F. Gianfrancesco, T. Esposito, C. Liquori, 2008, Neurogenetics.

Intracranial cavernous angioma: a practical review of clinical and biological aspects.

I. Awad, H. Batjer, R. Raychaudhuri, 2005, Surgical neurology.

Advances in the genetics of cerebrovascular disease and stroke

J. Marler, I. Awad, R. Latchaw, 2001, Neurology.

Expression of Endothelial Cell Angiogenesis Receptors in Human Cerebrovascular Malformations

I. Awad, R. Uranishi, P. Ng, 2001, Neurosurgery.

Multilocus linkage identifies two new loci for a mendelian form of stroke, cerebral cavernous malformation, at 7p15-13 and 3q25.2-27.

R. Scott, C. Ogilvy, I. Awad, 1998, Human molecular genetics.

Genetic heterogeneity of inherited cerebral cavernous malformation.

I. Awad, R. Lifton, M. Günel, 1996, Neurosurgery.

A founder mutation as a cause of cerebral cavernous malformation in Hispanic Americans.

L. Morrison, I. Awad, R. Lifton, 1996, The New England journal of medicine.

Epidural peg electrodes for the presurgical evaluation of intractable epilepsy.

G H Barnett, R C Burgess, H. Lüders, 1990, Neurosurgery.

Detection of changes in material-specific memory following temporal lobectomy using the Wechsler Memory Scale-Revised.

H. Lüders, G. Chelune, I. Awad, 1993, Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists.

Perfusion and Permeability MRI Predicts Future Cavernous Angioma Hemorrhage and Growth

R. Shenkar, I. Awad, Agnieszka Stadnik, 2021, Journal of magnetic resonance imaging : JMRI.

Molecular Biology of Cerebrovascular Diseases

I. Awad, R. Lifton, M. Gunel, 1998 .

Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

Dean Y. Li, L. Morrison, B. Hart, 2017, Nature.

Protracted 5-Fluorouracil Infusion with Concurrent Radiotherapy as a Treatment for Locally Advanced Pancreatic Carcinoma

I. Awad, M. Abou-Zaied, 2000 .

Minimally Invasive Surgery Plus Recombinant Tissue-type Plasminogen Activator for Intracerebral Hemorrhage Evacuation Decreases Perihematomal Edema

D. Hanley, J. Muschelli, P. Vespa, 2013, Stroke.

Symptomatic Chiari malformation in adults: a new classification based on magnetic resonance imaging with clinical and prognostic significance.

J. Hahn, P. Pillay, I. Awad, 1991, Neurosurgery.

Case problems conference: thoracic spinal cord hernia.

C. Dickman, I. Awad, J. Wong, 2000, Neurosurgery.

Mixed vascular malformations of the brain: clinical and pathogenetic considerations.

John R. Robinson, I. Awad, M. Estes, 1993, Neurosurgery.

Safety and efficacy of minimally invasive surgery plus recombinant tissue plasminogen activator in intracerebral haemorrhage evacuation (MISTIE): a randomised, phase 2 trial

D. Hanley, J. Muschelli, P. Vespa, 2016, The Lancet Neurology.

A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Phase III Study of Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage (CLEAR III)

D. Hanley, P. Vespa, C. Kase, 2014, International journal of stroke : official journal of the International Stroke Society.

Intractable complex partial seizures associated with occult temporal lobe encephalocele and meningoangiomatosis: a case report.

H. Lüders, I. Awad, D. Whiting, 1990, Surgical neurology.

Endothelial cell culture from human cerebral cavernous malformations.

I. Awad, N. I. Baev, 1998, Stroke.

Expression of angiogenic factors and structural proteins in central nervous system vascular malformations.

I. Awad, R. Harbaugh, J. Lee, 1996, Neurosurgery.

Expression of angiogenesis factors and selected vascular wall matrix proteins in intracranial saccular aneurysms.

I. Awad, J. Kim, G. Criscuolo, 1996, Neurosurgery.

Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions

I. Awad, S. Polster, L. Sansing, 2022, Circulation research.

Obituary: John F. Mullan, MD, 1925-2015: neurosurgery's modern statesman.

I. Awad, D. Frim, J. Hekmatpanah, 2016, Journal of neurosurgery.

Symptomatic Chiari Malformation in Adults: A New Classification

J. Hahn, P. Pillay, I. Awad, 1994 .

CSF inflammatory response after intraventricular hemorrhage

D. Hanley, I. Awad, W. Ziai, 2017, Neurology.

Basic and Translational Research in Intracerebral Hemorrhage: Limitations, Priorities, and Recommendations

T. Louis, C. Anderson, D. Hanley, 2018, Stroke.

J. Alpert, R. Adams, I. Awad, 2003, Circulation.

Council for High Blood Pressure Research Stroke Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and on behalf of the American Heart Association Stroke Council, Council on Cardiovascular and Towfighi,

K. Furie, L. McCullough, K. Rexrode, 2014 .

Focal parenchymal lesions in transient ischemic attacks: correlation of computed tomography and magnetic resonance imaging.

I. Awad, M. Modic, A. Furlan, 1986, Stroke.

ADVANCED MAGNETIC RESONANCE IMAGING OF CEREBRAL CAVERNOUS MALFORMATIONS: PART II. IMAGING OF LESIONS IN MURINE MODELS

R. Shenkar, I. Awad, A. Wyrwicz, 2008, Neurosurgery.

Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

R. Shenkar, I. Awad, M. Ginsberg, 2010, The Journal of experimental medicine.

Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu.

R. Shenkar, I. Awad, R. Girard, 2020, Journal of autoimmunity.

Research Update in Neuroscience for Neurosurgeons: a historical perspective.

A. Friedman, C. Hodge, N. Agarwal, 2019, Journal of neurosurgery.

Multiple Spinal Cavernous Malformations with Atypical Phenotype after Prior Irradiation: Case Report

J. Gault, I. Awad, P. Jabbour, 2004, Neurosurgery.

Biology of Vascular Malformations of the Brain

E. Golanov, W. Young, I. Awad, 2009, Stroke.

Multiple vertebral hemangiomas with neurological signs. Case report.

I. Awad, A. Gaston, J. Nguyen, 1992, Journal of neurosurgery.

Pathological heterogeneity of angiographically occult vascular malformations of the brain.

John R. Robinson, I. Awad, T. Masaryk, 1993, Neurosurgery.

De novo development of a cavernous malformation of the spinal cord following spinal axis radiation. Case report.

I. Awad, J. Knisely, S. Abdulrauf, 1999, Journal of neurosurgery.

CAVERNOUS MALFORMATIONS OF THE BASAL GANGLIA AND THALAMUS

I. Awad, B. Bendok, B. Gross, 2009, Neurosurgery.

Non-shunting cerebrovascular anomalies: Cavernous, capillary, and venous malformations

I. Awad, M. Dey, 2012 .

74 – Cerebral Cavernous Malformations and Venous Anomalies: Diagnosis, Natural History, and Clinical Management

I. Awad, H. Batjer, C. Eddleman, 2011 .

CCM CARE GUIDELINES 1

D. Kondziolka, B. Hart, I. Awad, 2017 .

Vascular pressures and cortical blood flow in cavernous angioma of the brain.

I. Awad, S. Jones, J. Little, 1990, Journal of neurosurgery.

Hemorrhage From Cavernous Malformations of the Brain: Definition and Reporting Standards

L. Morrison, I. Awad, R. Al‐Shahi Salman, 2008, Stroke.

Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage

J. C. Love, D. Hanley, A. Shalek, 2021, Science Immunology.

Combined petrosal approach

I. Awad, S. Polster, P. Horowitz, 2018, Current opinion in otolaryngology & head and neck surgery.

Management of Intraventricular Hemorrhage

I. Awad, S. Polster, J. Carrión-Penagos, 2022 .

Temporary and permanent occlusion of cervical and cerebral arteries.

I. Awad, E. Russell, B. Bendok, 2005, Neurosurgery clinics of North America.

Multidisciplinary coordinated care of hereditary hemorrhagic telangiectasia (Osler–Weber–Rendu disease)

R. Shenkar, I. Awad, U. Dyamenahalli, 2023, Vascular medicine.

Hemangioblastoma of the optic nerve : case report. Commentary

B. Scheithauer, S. Feldon, I. Awad, 1995 .

Delayed facial nerve palsy after temporal lobectomy for epilepsy: report of four cases and discussion of possible mechanisms.

J. Hahn, I. Awad, J. Anderson, 1991, Neurosurgery.

Radiosurgery for angiographically occult vascular malformations.

I. Awad, B. Bendok, Martin H. Pham, 2009, Neurosurgical focus.

Vascular Smooth Muscle Cell Differentiation in Human Cerebral Vascular Malformations

I. Awad, R. Uranishi, J. Kim, 2001, Neurosurgery.

External Ventricular Drainage for Intraventricular Hemorrhage

I. Awad, Agnieszka Stadnik, J. Jaffe, 2012, Current Neurology and Neuroscience Reports.

Minimally Invasive Surgery plus rt-PA for Intracerebral Hemorrhage Evacuation ( MISTIE ) Decreases Perihematomal Edema

D. Hanley, J. Muschelli, P. Vespa, 2014 .

RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations

R. Shenkar, I. Awad, Ying Cao, 2017, Stroke.

Plasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma

Kelly C. Weldon, M. D'Souza, R. Shenkar, 2023, Communications Medicine.

B-Cell Depletion Reduces the Maturation of Cerebral Cavernous Malformations in Murine Models

R. Shenkar, I. Awad, A. Louvi, 2016, Journal of Neuroimmune Pharmacology.

Bayesian deep learning outperforms clinical trial estimators of intracerebral and intraventricular hemorrhage volume

D. Hanley, J. Muschelli, I. Awad, 2022, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

Cerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials

H. Kamel, I. Awad, W. Ziai, 2021, Neurology.

Association Between Intraventricular Alteplase Use and Parenchymal Hematoma Volume in Patients With Spontaneous Intracerebral Hemorrhage and Intraventricular Hemorrhage

H. Kamel, D. Hanley, I. Awad, 2021, JAMA network open.

Post-Stroke Depression in Patients with Large Spontaneous Intracerebral Hemorrhage.

D. Hanley, I. Awad, W. Ziai, 2021, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

Intracranial Pressure and Cerebral Perfusion Pressure in Large Spontaneous Intracranial Hemorrhage and Impact of Minimally Invasive Surgery

D. Hanley, I. Awad, W. Ziai, 2021, Frontiers in Neurology.

Intracerebral Hemorrhage Volume Reduction and Timing of Intervention Versus Functional Benefit and Survival in the MISTIE III and STICH Trials.

D. Hanley, I. Awad, W. Ziai, 2021, Neurosurgery.

Impact of Intracranial Pressure Monitor-Guided Therapy on Neurologic Outcome After Spontaneous Nontraumatic Intracranial Hemorrhage.

D. Hanley, I. Awad, W. Ziai, 2020, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

Thrombolysis for Evacuation of Intracerebral and Intraventricular Hemorrhage: A Guide to Surgical Protocols With Practical Lessons Learned From the MISTIE and CLEAR Trials.

D. Hanley, I. Awad, W. Ziai, 2020, Operative neurosurgery.

Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu

J. C. Love, D. Hanley, A. Shalek, 2020, bioRxiv.

Prior antiplatelet therapy and haematoma expansion after primary intracerebral haemorrhage: an individual patient-level analysis of CLEAR III, MISTIE III and VISTA-ICH

H. Kamel, D. Hanley, I. Awad, 2020, Journal of Neurology, Neurosurgery, and Psychiatry.

A Pooled Analysis of Diffusion-Weighted Imaging Lesions in Patients With Acute Intracerebral Hemorrhage.

H. Kamel, D. Hanley, C. Iadecola, 2020, JAMA neurology.

Role of Temporal Sequence in Treating Intracerebral Hemorrhage

D. Hanley, I. Awad, W. Ziai, 2020, Annals of neurology.

Surgery for intracerebral haemorrhage – Authors' reply

D. Hanley, I. Awad, W. Ziai, 2019, The Lancet.

Surgical Performance Determines Functional Outcome Benefit in the Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation (MISTIE) Procedure.

Azam S. Ahmed, M. Malkoff, C. Anderson, 2019, Neurosurgery.

Surgical Performance in Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation Phase III Clinical Trial

D. Hanley, I. Awad, K. Lane, 2017, Neurosurgery.

Safety and efficacy of minimally invasive surgery plus alteplase in intracerebral haemorrhage evacuation (MISTIE): a randomised, controlled, open-label, phase 2 trial

D. Hanley, J. Muschelli, P. Vespa, 2016, The Lancet Neurology.

Stereotactic computed tomographic-guided aspiration and thrombolysis of intracerebral hematoma : protocol and preliminary experience.

I. Awad, P. Fayad, J. Montes, 2000, Stroke.

Common transcriptome, plasma molecules, and imaging signatures in the aging brain and a Mendelian neurovascular disease, cerebral cavernous malformation

R. Shenkar, I. Awad, T. Carroll, 2020, GeroScience.

Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma

L. Morrison, J. Gilbert, R. Shenkar, 2020, Nature Communications.

Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations

R. Shenkar, I. Awad, Ying Cao, 2019, Acta Neuropathologica Communications.

Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial.

L. Morrison, D. Hanley, R. Shenkar, 2018, Neurosurgery.

Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease.

Dean Y. Li, R. Shenkar, I. Awad, 2016, Biomarkers in medicine.

Immune response in human cerebral cavernous malformations.

R. Shenkar, I. Awad, Changbin Shi, 2009, Stroke.

Biallelic Somatic and Germ Line CCM1 Truncating Mutations in a Cerebral Cavernous Malformation Lesion

J. Gault, R. Shenkar, I. Awad, 2005, Stroke.

DBS reduced hemichorea associated with a developmental venous anomaly and microbleeding in STN

I. Awad, P. Warnke, U. Kang, 2014, Neurology.

The Natural History of Cavernous Malformations: A Prospective Study of 68 Patients

I. Awad, 1999 .

Factors predisposing to clinical disability in patients with cavernous malformations of the brain.

John R. Robinson, I. Awad, M. Magdinec, 1993, Neurosurgery.

Occurrence and impact of intracranial pressure elevation during treatment of severe intraventricular hemorrhage*

D. Hanley, I. Awad, C. Thompson, 2012, Critical care medicine.

Symptomatic Brain Hemorrhages from Cavernous Angioma Following Botulinum Toxin Injections, a role of TLR/MEKK3 Mechanism? A Case Report and Review of the Literature.

I. Awad, Agnieszka Stadnik, S. Polster, 2020, World neurosurgery.

Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease

R. Shenkar, I. Awad, Ying Cao, 2019, Stroke.

Quantitative susceptibility mapping as a monitoring biomarker in cerebral cavernous malformations with recent hemorrhage

Richard E Thompson, Daniel Hanley, Huan Tan, 2018, Journal of magnetic resonance imaging : JMRI.

Vascular Permeability in Cerebral Cavernous Malformations

R. Shenkar, I. Awad, Xiaodong Guo, 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Ultrastructural pathological features of cerebrovascular malformations: a preliminary report.

I. Awad, J. Wong, J. Kim, 2000, Neurosurgery.

Expression of basement membrane and endothelial cell adhesion molecules in vascular malformations of the brain: preliminary observations and working hypothesis.

I. Awad, B. Barna, P. Zhou, 1995, Neurological research.

Spread of malignant gliomas.

I. Awad, 1987, Journal of neurosurgery.

Dynamic Permeability and Quantitative Susceptibility: Related Imaging Biomarkers in Cerebral Cavernous Malformations

Tian Liu, Yi Wang, Robert R Edelman, 2014, Stroke.

Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation

C. Lengner, L. Morrison, Qin Zhu, 2019, Science Translational Medicine.

Variations in Structural Protein Expression and Endothelial Cell Proliferation in Relation to Clinical Manifestations of Cerebral Cavernous Malformations

J. Gault, H. Sarin, Nabil A Awadallah, 2005, Neurosurgery.

A Quality-of-Life Instrument for Young Hemorrhagic Stroke Patients

C. Wells, C. Viscoli, W. Kernan, 2001, Stroke.

Current updates in perioperative management of intracerebral hemorrhage.

I. Awad, B. Bendok, Patrick C. Hsieh, 2008, Neurosurgery clinics of North America.

Current updates in perioperative management of intracerebral hemorrhage.

I. Awad, B. Bendok, Patrick C. Hsieh, 2006, Neurologic clinics.

Spontaneous Intracerebral and Intraventricular Hemorrhage: Advances in Minimally Invasive Surgery and Thrombolytic Evacuation, and Lessons Learned in Recent Trials.

I. Awad, Agnieszka Stadnik, M. Dey, 2014, Neurosurgery.

Spontaneous intracerebral and intraventricular hemorrhage: advances in minimally invasive surgery and thrombolytic evacuation, and lessons learned in recent trials.

I. Awad, Agnieszka Stadnik, M. Dey, 2014, Neurosurgery.

Thrombolytic Evacuation of Intracerebral and Intraventricular Hemorrhage

Issam A Awad, I. Awad, Agnieszka Stadnik, 2012, Current Cardiology Reports.

OUTCOME PREDICTORS AND SPECTRUM OF TREATMENT ELIGIBILITY WITH PROSPECTIVE PROTOCOLIZED MANAGEMENT OF INTRACEREBRAL HEMORRHAGE

I. Awad, J. Jaffe, H. Batjer, 2009, Neurosurgery.

Genomics of Human Intracranial Aneurysm Wall

N. Jafari, Simon M. Lin, R. Shenkar, 2009, Stroke.

Proton magnetic resonance imaging in ischemic cerebrovascular disease

G. Beck, I. Awad, M. Modic, 1986, Annals of neurology.

Bushnell et al Guidelines for Prevention of Stroke in Women 1547 Incidence Ischemic Stroke

I. Piña, K. Furie, L. McCullough, 2014 .

Professionals From the American Heart Association / American Stroke Association Guidelines for the Prevention of Stroke in Women : A Statement for Healthcare

I. Piña, K. Furie, L. McCullough, 2014 .

Facts and Theories

I. Awad, A. Furlan, M. Chimowitz, 2005 .

Pathogenesis of Subcortical Hyperintense Lesions on Magnetic Resonance Imaging of the Brain: Observations in Patients Undergoing Controlled Therapeutic Internal Carotid Artery Occlusion

I. Awad, M. Magdinec, T. Masaryk, 1993, Stroke.

Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. II. Postmortem pathological correlations.

R F Spetzler, I. Awad, R. Spetzler, 1986, Stroke.

Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. I. Correlation with age and cerebrovascular risk factors.

R F Spetzler, I. Awad, R. Spetzler, 1986, Stroke.

Critical Care of the Stroke Patient: External ventricular drainage in hemorrhagic stroke

I. Awad, J. Jaffe, M. Dey, 2014 .

Radiosurgery and venous malformations.

I. Awad, 1994, Journal of neurosurgery.

MR of hereditary hemorrhagic telangiectasia: prevalence and spectrum of cerebrovascular malformations.

R. Fulbright, I. Awad, C. Putman, 1998, AJNR. American journal of neuroradiology.

CASE PROBLEMS IN NEUROLOGICAL SURGERY

I. Awad, J. Wong, J. Bolognia, 2000 .

Case Report: Management of Traumatic Carotid-Cavernous Fistulas in the Acute Setting of Penetrating Brain Injury

I. Awad, C. Lazaridis, Andrea Loggini, 2022, Frontiers in Neurology.

Hemorrhagic lesion at the tentorial incisura in a patient with facial nevus.

I. Awad, J. Wong, J. Bolognia, 1999, Neurosurgery.

Vascular permeability and iron deposition biomarkers in longitudinal follow-up of cerebral cavernous malformations.

Huan Tan, Issam A Awad, Ying Cao, 2017, Journal of neurosurgery.

Cerebral cavernous malformations and epilepsy.

I. Awad, P. Jabbour, 2006, Neurosurgical focus.

A comparison of the clinical profile of cavernous malformations with and without associated venous malformations.

I. Awad, S. Abdulrauf, M. Kaynar, 1999, Neurosurgery.

Exceptional multiplicity of cerebral arteriovenous malformations associated with hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome).

R. Fulbright, I. Awad, C. Putman, 1996, AJNR. American journal of neuroradiology.

The Prospective Natural History of Cerebral Venous Malformations

I. Awad, S. Abdulrauf, 1998 .

COVID-19 in a Hemorrhagic Neurovascular Disease, Cerebral Cavernous Malformation

R. Shenkar, I. Awad, Agnieszka Stadnik, 2021, Journal of Stroke & Cerebrovascular Diseases.

Intracranial hypertension associated with unruptured cerebral arteriovenous malformations

I. Awad, A. Furlan, M. Chimowitz, 1990, Annals of neurology.

Credulity of exploratory trials for cerebral cavernous malformations

R. Shenkar, I. Awad, 2022, The Lancet Neurology.

Internal carotid artery occlusion for cavernous segment aneurysm.

I. Awad, J. Rosenfeld, J. Little, 1989, Neurosurgery.

Therapeutic carotid occlusion: current management paradigms.

I. Awad, S. Lee, 2000, Clinical neurosurgery.

Giant aneurysms of the anterior circle of Willis: management outcome of open microsurgical treatment.

I. Awad, R. Gewirtz, 1996, Surgical neurology.

Magnetic Resonance Imaging Evaluation of Cerebral Cavernous Malformations With Susceptibility-Weighted Imaging

Hugues Duffau, Issam A Awad, Nicolas Menjot de Champfleur, 2011, Neurosurgery.

Management of incidental cavernous malformations: a review.

I. Awad, S. Tjoumakaris, R. Rosenwasser, 2011, Neurosurgical focus.

Further observations on the pathology of subcortical lesions identified on magnetic resonance imaging.

I. Awad, A. Furlan, M. Chimowitz, 1992, Archives of neurology.

Sclerosing vasculopathy of the central nervous system in nonelderly demented patients.

I. Awad, N. Ratliff, J. Mcmahon, 1991, Archives of neurology.

Cerebrovascular surgery: from the Wild West through the endovascular revolution. The M. Gazi Yaşargil Lecture at the American Association of Neurological Surgeons 2021 Annual Scientific Meeting.

I. Awad, P. Purdy, H. Batjer, 2022, Journal of neurosurgery.

Stroke Council of the American Heart Association Intracranial Aneurysms : A Statement for Healthcare Professionals From the Recommendations for the Management of Patients With Unruptured

D. Wiebers, I. Awad, T. Brott, 2009 .

Extent of Resection in Temporal Lobectomy for Epilepsy. I. Interobserver Analysis and Correlation with Seizure Outcome

J. Hahn, H. Lüders, I. Awad, 1989, Epilepsia.

Extent of Resection in Temporal Lobectomy for Epilepsy. II. Memory Changes and Neurologic Complications

H. Lüders, G. Chelune, I. Awad, 1989, Epilepsia.

Temporal Evolution and Outcomes of Non-Traumatic Intracerebral Hemorrhage in Hospitalized Patients.

I. Awad, C. Lazaridis, Andrea Loggini, 2021, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

Accuracy of the ABC/2 Score for Intracerebral Hemorrhage: Systematic Review and Analysis of MISTIE, CLEAR-IVH, and CLEAR III

John Muschelli, Michael D Hill, Issam A Awad, 2015, Stroke.

Symptomatic Hemorrhagic Complications in Clot Lysis: Evaluation of Accelerated Resolution of Intraventricular Hemorrhage Phase III Clinical Trial (CLEAR III) A Posthoc Root-Cause Analysis

D. Hanley, I. Awad, W. Ziai, 2018, Neurosurgery.

Ventricular catheter location and the clearance of intraventricular hemorrhage.

D. Hanley, J. Muschelli, I. Awad, 2012, Neurosurgery.

Anterior temporal lobectomy with microsurgical resection of mesial structures: Surgical technique and results in 50 consecutive patients with intractable epilepsy

H. Lüders, G. Chelune, I. Awad, 1991 .

Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations

C. Glass, R. Shenkar, I. Awad, 2017, The Journal of experimental medicine.

Unfolding knowledge on cerebral cavernous malformations.

I. Awad, 2005, Surgical neurology.

Sensitivity of magnetic resonance diffusion-weighted imaging and regional relationship between the apparent diffusion coefficient and cerebral blood flow in rat focal cerebral ischemia.

T. Ng, I. Awad, S. Jones, 1995, Stroke.

Magnetic resonance diffusion-weighted imaging: sensitivity and apparent diffusion constant in stroke.

I. Awad, S. Jones, A. Furlan, 1994, Acta neurochirurgica. Supplementum.

Demographic Risk Factors for Vascular Lesions as Etiology of Intraventricular Hemorrhage in Prospectively Screened Cases

D. Hanley, I. Awad, W. Ziai, 2017, Cerebrovascular Diseases.

Cerebrovascular Complications in Early Survivors of Civilian Penetrating Brain Injury

I. Awad, C. Lazaridis, S. Polster, 2020, Neurocritical Care.

Post-Trial Enhanced Deployment and Technical Performance with the MISTIE Procedure per Lessons Learned.

D. Hanley, I. Awad, M. Sharrock, 2021, Journal of Stroke & Cerebrovascular Diseases.

Corrigendum: Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling

Dean Y. Li, R. Shenkar, I. Awad, 2016, Nature.

A randomized trial of brief treatment of early- stage Hodgkin lymphoma: Is it effective?

I. Awad, A. Anter, R. Hamed, 2012, Hematology/oncology and stem cell therapy.

Thrombolysis Trial Resolution in Brain Hemorrhage : The Intraventricular Hemorrhage Low-Dose Recombinant Tissue-Type Plasminogen Activator Enhances Clot

S. Mayer, D. Hanley, A. Marmarou, 2011 .

Fenestration of supraclinoid internal carotid artery and associated aneurysm: embryogenesis, recognition, and management.

Issam A Awad, I. Awad, M. Dey, 2011, World neurosurgery.

Common transcriptome, plasma molecules, and imaging signatures in the aging brain and a Mendelian neurovascular disease, cerebral cavernous malformation

R. Shenkar, I. Awad, Agnieszka Stadnik, 2020, GeroScience.

A randomized 500-subject open-label phase 3 clinical trial of minimally invasive surgery plus alteplase in intracerebral hemorrhage evacuation (MISTIE III)

C. Anderson, D. Hanley, P. Vespa, 2019, International journal of stroke : official journal of the International Stroke Society.

Cerebral Cavernous Malformations: Advanced Magnetic Resonance Imaging

R. Shenkar, I. Awad, S. Ansari, 2011 .

Comparison and spacial correlation of interictal HMPAO-SPECT and FDG-PET in intractable temporal lobe epilepsy.

P. Coubes, I. Awad, M. Antar, 1993, Neurological research.

Innovation through minimalism: assessing emerging technology in neurosurgery.

I. Awad, 1996, Clinical neurosurgery.

Quantitative Susceptibility Mapping and Vessel Wall Imaging as Screening Tools to Detect Microbleed in Sentinel Headache

J. Torner, I. Awad, T. Carroll, 2020, Journal of Clinical Medicine.

Cavernous Angioma Symptomatic Hemorrhage (CASH) Trial Readiness II: Imaging Biomarkers and Trial Modeling

B. Hart, H. Sair, R. Shenkar, 2023, medRxiv.

Intravenous digital subtraction angiography: an index of collateral cerebral blood flow in internal carotid artery occlusion.

I. Awad, M. Modic, A. Furlan, 1982, Stroke.

Conversion of an intracranial arterial stenosis to a symptomatic occlusion after EC/IC bypass surgery.

I. Awad, A. Furlan, J. Little, 1983, Neurosurgery.

[Genetic factors related to intracranial arteriovenous malformations].

I. Awad, J. Wong, R. Moussa, 2001, Neuro-Chirurgie.

Periventricular lesions on MRI. Facts and theories.

I. Awad, A. Furlan, M. Chimowitz, 1989, Stroke.

Subarachnoid hemorrhage and choir singing.

I. Awad, P. Mayer, 1994, Journal of neurosurgery.

Relationship of White Matter Lesions with Intracerebral Hemorrhage Expansion and Functional Outcome: MISTIE II and CLEAR III

D. Hanley, J. Muschelli, B. Norrving, 2020, Neurocritical Care.

Influence of Bleeding Pattern on Ischemic Lesions After Spontaneous Hypertensive Intracerebral Hemorrhage with Intraventricular Hemorrhage

D. Hanley, I. Awad, W. Ziai, 2018, Neurocritical Care.

Spine patient outcomes research trial.

I. Awad, P. Mccormick, S. Dunsker, 2003, Journal of neurosurgery.

Incidental lesions noted on magnetic resonance imaging of the brain: prevalence and clinical significance in various age groups.

I. Awad, R. Spetzler, J. Hodak, 1987, Neurosurgery.

BRAIN WATER, ICP AND BRAIN RELAXATIONA COMPARISON OF MANNITOL AND FUROSEMIDE

I. Awad, A. Schubert, E. Bloomfield, 1991 .

The Effect of Propofol on the Electroencephalogram of Patients with Epilepsy

I. Awad, P. V. Van Ness, A. Schubert, 1992, Anesthesia and analgesia.

Update on current registries and trials of carotid artery angioplasty and stent placement.

I. Awad, B. Bendok, Sunit Das, 2005, Neurosurgical focus.

Primary intracerebral hemorrhage and subarachnoid hemorrhage.

I. Awad, A. Furlan, S. Abdulrauf, 1999, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

Syringomyelia and the Chiari Malformations

E. Benzel, I. Awad, J. Anson, 1997 .

Underlying intracranial atherosclerotic disease is associated with worse outcomes in acute large vessel occlusion undergoing endovascular thrombectomy.

I. Awad, T. Karrison, S. Prabhakaran, 2023, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

Baseline Characteristics of Patients With Cavernous Angiomas With Symptomatic Hemorrhage in Multisite Trial Readiness Project

D. Hanley, I. Awad, J. Narvid, 2021, Stroke.

Microsoft Word-312680_PAP_05_02_18

Dean Y. Li, R. Shenkar, I. Awad, 2018 .

External ventricular drain-related infections: dilemmas of definitions, generalisability and associations versus causations

I. Awad, 2017, Journal of Neurology, Neurosurgery, and Psychiatry.

Differences of In Vitro Electrophysiology of Hippocampal Neurons from Epileptic Patients with Mesiotemporal Sclerosis Versus Structural Lesions

I. Awad, M. Nayel, W. Knowles, 1992, Epilepsia.

Fatal “hypertensive” intracerebral hemorrhage associated with a cerebral cavernous angioma: case report

I. Awad, R. Wollmann, M. Dey, 2011, Acta Neurochirurgica.

Giant aneurysms of the proximal anterior cerebral artery: report of three cases.

I. Awad, R. Gewirtz, 1993, Neurosurgery.

Effect of local anaesthetic volume (20 vs 5 ml) on the efficacy and respiratory consequences of ultrasound-guided interscalene brachial plexus block.

I. Awad, C. McCartney, N. Carmichael, 2008, British journal of anaesthesia.

TRANSRADIAL APPROACH: TECHNICAL CASE REPORT

I. Awad, B. Bendok, H. Batjer, 2005 .

Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations

W. Min, R. Shenkar, I. Awad, 2014, Genetics in Medicine.

Methods and Design Considerations for Randomized Clinical Trials Evaluating Surgical or Endovascular Treatments for Cerebrovascular Diseases

C. Hodge, P. Stieg, R. Higashida, 2004, Neurosurgery.

Cerebral Cavernous Malformation

I. Awad, D. Marchuk, R. Girard, 2021, Circulation research.

Impact of socioeconomics and race on clinical follow-up and trial enrollment and adherence in cerebral cavernous malformation.

R. Shenkar, I. Awad, Agnieszka Stadnik, 2023, Journal of Stroke & Cerebrovascular Diseases.

Comparison of the clinical presentation of symptomatic arteriovenous malformations (angiographically visualized) and occult vascular malformations.

John R. Robinson, I. Awad, R. Sarabia, 1993, Neurosurgery.

Determinants of External Ventricular Drain Placement and Associated Outcomes in Patients with Spontaneous Intraventricular Hemorrhage

D. Hanley, I. Awad, C. Thompson, 2014, Neurocritical Care.

Recommendations for the management of patients with unruptured intracranial aneurysms: A statement for healthcare professionals from the Stroke Council of the American Heart Association.

D. Wiebers, I. Awad, T. Brott, 2000, Circulation.

Preliminary report of the clot lysis evaluating accelerated resolution of intraventricular hemorrhage (CLEAR-IVH) clinical trial.

D. Hanley, I. Awad, P. Keyl, 2008, Acta neurochirurgica. Supplement.

Primary intraventricular hemorrhage outcomes in the CLEAR III trial

Sarah E. Nelson, D. Hanley, I. Awad, 2020, International journal of stroke : official journal of the International Stroke Society.

Occult intracranial aneurysms in polycystic kidney disease: screening with MR angiography.

N. Obuchowski, J. Lewin, J. Lewin, 1994, Radiology.

Creutzfeldt-Jakob disease in the elderly.

I. Awad, R. de Silva, R. Will, 1997, Postgraduate medical journal.

Biology of Vascular Malformations of the Brain

E. Golanov, W. Young, I. Awad, 2009, Stroke.

Detection of microbleeds associated with sentinel headache using MRI quantitative susceptibility mapping: pilot study.

J. Greenlee, V. Magnotta, J. Torner, 2019, Journal of neurosurgery.

A Statement for Healthcare Professionals from the American Heart Association/american Stroke Association on Behalf of the American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Council for H

I. Piña, K. Furie, L. McCullough, 2022 .

Effect of local anaesthetic volume (20 vs 5 ml) on the efficacy and respiratory consequences of ultrasound-guided interscalene brachial plexus block.

I. Awad, C. McCartney, N. Carmichael, 2008, British journal of anaesthesia.

Biomarkers of cavernous angioma with symptomatic hemorrhage.

R. Shenkar, I. Awad, Agnieszka Stadnik, 2019, JCI insight.

Galen's anecdote of the fallen sophist: on the certainty of science through anatomy.

I. Awad, 1995, Journal of neurosurgery.

Inflammatory Mechanisms in a Neurovascular Disease: Cerebral Cavernous Malformation

R. Shenkar, I. Awad, R. Girard, 2023, Brain sciences.

A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.

R. Kucherlapati, R. Shenkar, I. Awad, 2011, Human molecular genetics.

Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis.

D. Corcoran, R. Shenkar, I. Awad, 2014, Human molecular genetics.

D. Kondziolka, P. Stieg, W. Young, 2001, Stroke.

Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial

J. Muschelli, P. Vespa, H. Adams, 2017, The Lancet.

Hemorrhage From Cavernous Malformations of the Brain: Definition and Reporting Standards

L. Morrison, I. Awad, R. Al‐Shahi Salman, 2008, Stroke.

Ruptured superior cerebellar artery aneurysm in a child with bilateral fibromuscular hyperplasia of the renal arteries: case report and review of the literature.

I. Awad, B. Bendok, H. Batjer, 2005, Journal of neurosurgery.

[Etiologic spectrum of intracerebral hemorrhage in young patients].

I. Awad, R. Moussa, G. Nohra, 2006, Neuro-Chirurgie.

Genomics of Human Intracranial Aneurysm Wall

N. Jafari, Simon M. Lin, R. Shenkar, 2009, Stroke.

Association of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis

I. Awad, W. Ziai, Radhika Avadhani, 2022, Stroke.

Supplementary Materials and Methods

R. Shenkar, I. Awad, Changbin Shi, 2022 .

Minimally Invasive Surgery With Thrombolysis for Intracerebral Hemorrhage Evacuation

I. Awad, W. Ziai, F. Vahidy, 2023, Neurology.

Perioperative Management and Outcome after Surgical Treatment of Anterior Cerebral Artery Aneurysms

I. Awad, J. Little, 1991, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

hemorrhagic telangiectasia (Osler-Weber-Rendu malformations associated with hereditary Exceptional multiplicity of cerebral arteriovenous

I. Awad, C. Putman, J. Chaloupka, 2022 .

Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

R. Shenkar, I. Awad, M. Ginsberg, 2010, The Journal of experimental medicine.

Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations. (I2-2B)

I. Awad, A. Mikati, Amy L Akers, 2015, Neurology.

mTORC1 Inhibitor Rapamycin Inhibits Growth of Cerebral Cavernous Malformation in Adult Mice

R. Shenkar, I. Awad, D. Marchuk, 2023, Stroke.

A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease

R. Shenkar, I. Awad, Ying Cao, 2019, Translational Stroke Research.

Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease Through CX3CR1-CX3CL1 Signaling

R. Shenkar, I. Awad, R. Girard, 2024, Arteriosclerosis, thrombosis, and vascular biology.

Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism in animal models.

R. Shenkar, I. Awad, Ying Cao, 2021, The Journal of clinical investigation.

Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part II: Biomarkers and Trial Modeling

B. Hart, R. Shenkar, I. Awad, 2023, Stroke.

Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part I: Event Rates and Clinical Outcome

B. Hart, R. Shenkar, I. Awad, 2023, Stroke.

Reversal of a dense, persistent, holohemispheric neurological deficit after an endarterectomy of the carotid artery: case report.

I. Awad, C. Sila, R. Mckenzie, 1992, Neurosurgery.