T. Strachan

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Derivation, growth and applications of human embryonic stem cells.

A. Murdoch, M. Stojkovic, M. Lako, 2004, Reproduction.

Human Molecular Genetics 2

T. Strachan, A. Read, 1997 .

3D modelling, gene expression mapping and post-mapping image analysis in the developing human brain

R. Baldock, D. Davidson, J. Sharpe, 2005, Brain Research Bulletin.

Characterization of an expressible nonclassical class I HLA gene.

M. Tassabehji, R. Campbell, T. Strachan, 1991, Human immunology.

Neural crest cell‐specific inactivation of Nipbl or Mau2 during mouse development results in a late onset of craniofacial defects

T. Strachan, T. G. Smith, S. Laval, 2014, Genesis.

Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation.

T. Strachan, 2005, Current opinion in genetics & development.

NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome

Tom Strachan, M. Bamshad, T. Strachan, 2004, Nature Genetics.

Downregulation of NANOG Induces Differentiation of Human Embryonic Stem Cells to Extraembryonic Lineages

L. Hyslop, A. Murdoch, M. Herbert, 2005, Stem cells.

3 dimensional modelling of early human brain development using optical projection tomography

Richard Baldock, Duncan Davidson, James Sharpe, 2004, BMC Neuroscience.

The short stature homeobox gene SHOX is involved in skeletal abnormalities in Turner syndrome.

I. Glass, T. Strachan, R. Zeller, 2000, Human molecular genetics.

HUMAN GENOME EVOLUTION

T. Strachan, M. Jackson, G. Dover, 2004 .

Identification of a novel family of human endogenous retroviruses and characterization of one family member, HERV-K(C4), located in the complement C4 gene cluster.

M. Tassabehji, R. Campbell, M. Lako, 1994, Nucleic acids research.

A homeobox gene, HLXB9, is the major locus for dominantly inherited sacral agenesis

S. Scherer, P. Scambler, W. Reardon, 1998, Nature Genetics.

A new dimension for the human genome project: towards comprehensive expression maps

J. Beckmann, D. Davidson, T. Strachan, 1997, Nature Genetics.

A gene for autosomal dominant sacral agenesis maps to the holoprosencephaly region at 7q36

E. Mariman, R. Balling, A. Copp, 1995, Nature Genetics.

Tandem duplication within a neurofibromatosis type 1 (NF1) gene exon in a family with features of Watson syndrome and Noonan syndrome.

M. Tassabehji, T. Strachan, D. Donnai, 1993, American journal of human genetics.

Breakpoint position on 17q identifies the most aggressive neuroblastoma tumors

T. Strachan, M. Jackson, J. Lunec, 2002, Genes, chromosomes & cancer.

ATP2A2 mutations in Darier's disease: variant cutaneous phenotypes are associated with missense mutations, but neuropsychiatric features are independent of mutation class.

T. Strachan, P. Itin, D. Hohl, 1999, Human molecular genetics.

A de novo pathological point mutation at the 21–hydroxylase locus: implications for gene conversion in the human genome

M. Tassabehji, T. Strachan, S. Collier, 1993, Nature Genetics.

Spinal and cutaneous schwannomatosis is a variant form of type 2 neurofibromatosis: a clinical and molecular study.

D. Evans, T. Strachan, S. Huson, 1997, Journal of neurology, neurosurgery, and psychiatry.

Somatic mosaicism: a common cause of classic disease in tumor-prone syndromes? Lessons from type 2 neurofibromatosis.

D. Evans, T. Strachan, R. Ramsden, 1998, American journal of human genetics.

Towards effective and rewarding data sharing [Editorial]

Anders M. Dale, Arthur W. Toga, Neil R. Smalheiser, 2003 .

Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25.

M. Lako, T. Strachan, S. Lindsay, 1997, Gene.

Human post-implantation embryo collection: medical and surgical techniques.

T. Strachan, S. Robson, P. Bullen, 1998, Early human development.

Genomic organisation of the human chordin gene and mutation screening of candidate Cornelia de Lange syndrome genes

T. Strachan, R. Skoda, A. Wiestner, 1999, Human Genetics.

Refined genetic mapping of the darier locus to a <1-cM region of chromosome 12q24.1, and construction of a complete, high-resolution P1 artificial chromosome/bacterial artificial chromosome contig of the critical region.

A. Monaco, R. Cox, M. Lathrop, 1998, American journal of human genetics.

Molecular cytogenetic delineation of 17q translocation breakpoints in neuroblastoma cell lines

F. Speleman, T. Strachan, M. Jackson, 1998, Genes, chromosomes & cancer.

Noonan Syndrome

M. Tassabehji, T. Strachan, N. Thakker, 2006 .

Expression of steroidogenic factor 1 and Wilms' tumour 1 during early human gonadal development and sex determination

David I. Wilson, H. Ostrer, T. Strachan, 1999, Mechanisms of Development.

Genotype/phenotype correlations in type 2 neurofibromatosis (NF2): evidence for more severe disease associated with truncating mutations.

D. Evans, T. Strachan, A. Wallace, 1998, Journal of medical genetics.

A mutation in the neurofibromatosis type 2 tumor-suppressor gene, giving rise to widely different clinical phenotypes in two unrelated individuals.

D. Evans, T. Strachan, J. Goodship, 1994, American journal of human genetics.

Hailey–Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca2+ pump

A. Monaco, H. Lehrach, J. Ramser, 2000 .

A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas

A. Harris, T. Strachan, S. Ruben, 1997, Oncogene.

Diagnostic issues in a family with late onset type 2 neurofibromatosis.

D. Evans, T. Strachan, R. Ramsden, 1995, Journal of medical genetics.

Presymptomatic DNA and MRI diagnosis of neurofibromatosis 2 with mild clinical course in an extended pedigree

L. Peltonen, O. Salonen, A. Palotie, 1995, Neurology.

HLA Class I Genes: From Structure to Expression, Serology and Function

T. Strachan, F. Lemonnier, R. Sodoyer, 1985, Immunological reviews.

MOLECULAR PATHOLOGY OF CONGENITAL ADRENAL HYPERPLASIA

T. Strachan, 1990, Clinical endocrinology.

Molecular drive.

T. Strachan, E. Coen, G. Dover, 2002, Science.

Localisation of a gene for Darier's disease.

T. Strachan, J. Rees, C. Munro, 1993, Human molecular genetics.

Complete nucleotide sequence of a unique HLA class I C locus product expressed on the human choriocarcinoma cell line BeWo.

M. Palmer, A. McMichael, T. Strachan, 1989, Journal of immunology.

Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung.

M. Lako, T. Strachan, S. Lindsay, 1998, Gene.

Molecular basis of splotch and Waardenburg Pax-3 mutations.

M. Goulding, T. Strachan, G. Chalepakis, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Keratin 16 and keratin 17 mutations cause pachyonychia congenita

E. Lane, T. Strachan, I. Leigh, 1995, Nature Genetics.

Molecular analysis of the human MHC class I region in hereditary haemochromatosis

I. Dunham, R. Campbell, T. Strachan, 1990, Human Genetics.

An HLA-C-specific DNA probe

T. Strachan, R. Sodoyer, A. Dodge, 2004, Immunogenetics.

A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A

M. Stojkovic, M. Lako, T. Strachan, 2009, The Journal of cell biology.

A role for NANOG in G 1 to S transition in human embryonic stem cells through direct binding of CDK 6 and CDC 25 A

M. Stojkovic, M. Lako, T. Strachan, 2009 .

21-hydroxylase deficiency families with HLA identical affected and unaffected sibs.

T. Strachan, P. Sinnott, D. Price, 1989, Journal of medical genetics.

Molecular genetics and polymorphism of class I HLA antigens.

T. Strachan, 1987, British medical bulletin.

The HLA-AW24 gene: Sequence, surroundings and comparison with the HLA-A2 and HLA-A3 genes

T. Strachan, R. Sodoyer, B. Jordan, 2004, Immunogenetics.

Partial cloning and assignment1 of WNT6 to human chromosome band 2q35 by in situ hybridization

M. Lako, T. Strachan, S. Lindsay, 1999, Cytogenetic and Genome Research.

Identification and characterisation of novel mammalian homologues of Drosophila polyhomeotic permits new insights into relationships between members of the polyhomeotic family

T. Strachan, E. Tonkin, Donna-Marie Hagan, 2002, Human Genetics.

Identification of the primary gene defect at the cytochrome P450 CYP2D

I. Dunham, T. Strachan, A. Bomford, 1991 .

A genetic study of type 2 neurofibromatosis in the United Kingdom. II. Guidelines for genetic counselling.

D. Evans, T. Strachan, S. Huson, 1992, Journal of medical genetics.

Polymerase chain reaction analysis of transcriptional patterns of expression of class I HLA genes.

T. Strachan, M. Pook, V. Woodcock, 1991, Human immunology.

Molecular pathology of steroid 21-hydroxylase deficiency

T. Strachan, P. White, 1991, The Journal of Steroid Biochemistry and Molecular Biology.

Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family

David I. Wilson, T. Strachan, A. Buckler, 1997, Nature Genetics.

Molecular characterisation of C4 null alleles found in Felty's syndrome.

T. Strachan, M. Hillarby, D. Grennan, 1990, Annals of the rheumatic diseases.

Molecular characterisation ofC4nullalleles found inFelty's syndrome

T. Strachan, M. Hillarby, D. Grennan, 1990 .

Exclusion of linkage to the CDL1 gene region on chromosome 3q26.3 in some familial cases of Cornelia de Lange syndrome.

I. Krantz, M. Devoto, M. Hofreiter, 2001, American journal of medical genetics.

Allelism in the HLA class I multigene family.

T. Strachan, R. Sodoyer, B. Jordan, 1985, Annales de l'Institut Pasteur. Immunologie.

Diffuse bilateral cerebral astrocytomas with atypical neuroimaging studies.

J. Cairncross, T. Strachan, M. Weinstein, 1994, Journal of neurosurgery.

Hailey-Hailey disease: molecular and clinical characterization of novel mutations in the ATP2C1 gene.

A. Monaco, T. Strachan, R. Sudbrak, 2002, The Journal of investigative dermatology.

Focus on ART Derivation, growth and applications of human embryonic stem cells

M. Stojkovic, M. Lako, T. Strachan, 2004 .

A clinical, genetic and audiological study of patients and families with bilateral acoustic neurofibromatosis

D. Evans, T. Strachan, R. Ramsden, 1993, The Journal of Laryngology & Otology.

Variation of expression of the gene for type 2 neurofibromatosis: absence of a gender effect on vestibular schwannomas, but confirmation of a preponderance of meningiomas in females

D. Evans, T. Strachan, R. Ramsden, 1995, The Journal of Laryngology & Otology.

A perspective on inversin

T. Strachan, J. Goodship, L. Turnpenny, 2004, Cell biology international.

Molecular cytogenetic definition of 17q translocation breakpoints in neuroblastoma.

F. Speleman, T. Strachan, M. Jackson, 2001, Medical and pediatric oncology.

PRENATAL DIAGNOSIS OF CONGENITAL ADRENAL HYPERPLASIA

T. Strachan, P. Sinnott, Rodney Harris, 1987, The Lancet.

CYP21/C4 gene organisation in Italian 21-hydroxylase deficiency families

T. Strachan, P. Sinnott, Rodney Harris, 1992, Human Genetics.

Extended MHC haplotypes and CYP21/C4 gene organisation in Irish 21-hydroxylase deficiency families

T. Strachan, C. Costigan, P. Sinnott, 1991, Human Genetics.

Mutation screening in British 21-hydroxylase deficiency families and development of novel microsatellite based approaches to prenatal diagnosis

R. Campbell, M. Lako, T. Strachan, 1999, Journal of medical genetics.

A method for specific amplification and PCR sequencing of individual members of multigene families: application to the study of steroid 21-hydroxylase deficiency.

M. Tassabehji, T. Strachan, S. Collier, 1992, PCR methods and applications.

A giant novel gene undergoing extensive alternative splicing is severed by a Cornelia de Lange-associated translocation breakpoint at 3q26.3

I. Krantz, T. Strachan, S. Lindsay, 2004, Human Genetics.

Partial trisomy 3q and the mild Cornelia de Lange syndrome phenotype.

T. Strachan, S. Lindsay, I. Cross, 1995, Journal of medical genetics.

Genetics and Genomics in Medicine

T. Strachan, P. Chinnery, J. Goodship, 2014 .

Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease

N. Craddock, M. O’Donovan, A. Monaco, 1999, Nature Genetics.

Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca(2+) pump.

A. Monaco, H. Lehrach, J. Ramser, 2000, Human molecular genetics.

Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene

R. Balling, M. Tassabehji, T. Strachan, 1992, Nature.

Mutations in the PAX3 gene causing Waardenburg syndrome type 1 and type 2

M. Tassabehji, M. Patton, T. Strachan, 1993, Nature Genetics.

Autosomal dominant sacral agenesis: Currarino syndrome

T. Strachan, S. Lindsay, J. Burn, 2000, Journal of medical genetics.

MHC class I expression by developmental tumors: teratocarcinoma stem cells are TCA positive.

T. F. Rinke de Wit, P. Stern, T. Strachan, 1988, Human immunology.

Running title : In Vitro Derived Human Sperm Title : Derivation of Human Sperm from Embryonic Stem Cells

A. Murdoch, M. Herbert, M. Stojkovic, 2009 .

Mutation analysis and embryonic expression of the HLXB9 Currarino syndrome gene.

P. Scambler, W. Reardon, R. Winter, 2000, American journal of human genetics.

SRY, SOX9, and DAX1 expression patterns during human sex determination and gonadal development

David I. Wilson, H. Ostrer, T. Strachan, 2000, Mechanisms of Development.

J. Beckmann, K. Bushby, M. Lako, 1998, Nature Genetics.

Molecular genetics in the National Health Service in Britain.

D. Craufurd, T. Strachan, A. Read, 1989, Journal of medical genetics.

Molecular genetics intheNational HealthService inBritain

D. Craufurd, T. Strachan, A. Read, 1989 .

A sequence-ready physical map of a region of 12q24.1.

A. Monaco, R. Kucherlapati, T. Strachan, 1997, Genomics.

Our place in the tree of life

T. Strachan, A. Read, 1999 .

Derivation of Human Embryonic Stem Cells from Day‐8 Blastocysts Recovered after Three‐Step In Vitro Culture

L. Hyslop, A. Murdoch, M. Herbert, 2004, Stem cells.

PAX3 gene structure and mutations: close analogies between Waardenburg syndrome and the Splotch mouse.

M. Tassabehji, T. Strachan, A. Read, 1994, Human molecular genetics.

Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination

T. Strachan, B. Schermer, T. Benzing, 2003, Nature Genetics.

Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycle.

T. Strachan, J. Goodship, J. Sayer, 2002, Human molecular genetics.

A gene for autosomal recessive limb-girdle muscular dystrophy maps to chromosome 2p.

K. Bushby, T. Strachan, L. Nashef, 1994, Human molecular genetics.

Genetic mapping of complex characters

T. Strachan, A. Read, 1999 .

Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse

L. Matthews, T. Strachan, J. Goodship, 1998, Nature Genetics.

Molecular pathology of 21-hydroxylase deficiency

T. Strachan, 1994, Journal of Inherited Metabolic Disease.

An Autogeneic Feeder Cell System That Efficiently Supports Growth of Undifferentiated Human Embryonic Stem Cells

Stefan Przyborski, Majlinda Lako, Tom Strachan, 2005, Stem cells.

A disease-associated germline deletion maps the type 2 neurofibromatosis (NF2) gene between the Ewing sarcoma region and the leukaemia inhibitory factor locus.

L. Gaunt, T. Strachan, R. Harris, 1993, Human molecular genetics.

A genetic study of type 2 neurofibromatosis in the United Kingdom. I. Prevalence, mutation rate, fitness, and confirmation of maternal transmission effect on severity.

D. Evans, T. Strachan, S. Huson, 1992, Journal of medical genetics.

Silencing of the expression of pluripotent driven-reporter genes stably transfected into human pluripotent cells.

M. Stojkovic, M. Lako, T. Strachan, 2008, Regenerative medicine.

Dynamics of concerted evolution of ribosomal DNA and histone gene families in the melanogaster species subgroup of Drosophila.

T. Strachan, E. Coen, G. Dover, 1982, Journal of molecular biology.

Metazoan Scc4 Homologs Link Sister Chromatid Cohesion to Cell and Axon Migration Guidance

A. Bateman, D. Dorsett, T. Strachan, 2006, PLoS biology.

Clinical and molecular correlates of somatic mosaicism in neurofibromatosis 2

D. Evans, T. Strachan, M. Baser, 2000, Journal of medical genetics.

Germline mutations in the neurofibromatosis type 2 tumour suppressor gene.

T. Strachan, D. Bourn, D. Gareth, 1994, Human molecular genetics.

The left-right determinant inversin has highly conserved ankyrin repeat and IQ domains and interacts with calmodulin

C. Tabin, T. Strachan, J. Goodship, 2002, Human Genetics.

Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia phenotype observed in CPX patients.

M. Patton, T. Strachan, S. Lindsay, 2002, Human molecular genetics.

Probability of bilateral disease in people presenting with a unilateral vestibular schwannoma

R T Ramsden, D. Evans, T. Strachan, 1999, Journal of neurology, neurosurgery, and psychiatry.

Human-mouse differences in the embryonic expression patterns of developmental control genes and disease genes.

J. Beckmann, T. Strachan, S. Lindsay, 2000, Human molecular genetics.

A clinical, genetic and audiological study of patients and families with unilateral vestibular schwannomas. I. Clinical features of neurofibromatosis in patients with unilateral vestibular schwannomas

D. Evans, T. Strachan, R. Ramsden, 1996, The Journal of Laryngology & Otology.

Pulsed field gel electrophoresis identifies a high degree of variability in the number of tandem 21‐hydroxylase and complement C4 gene repeats in 21‐hydroxylase deficiency haplotypes.

T. Strachan, P. Sinnott, S. Collier, 1989, The EMBO journal.

A. McMichael, T. Strachan, S. Ellis, 1989 .

DNA family turnover and the coevolution of chromosomes

T. Strachan, E. Coen, M. Trick, 1984 .

A novel mammalian wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain.

M. Lako, T. Strachan, S. Lindsay, 1998, Human molecular genetics.

Molecular Genetics of Early Human Development

David I. Wilson, T. Strachan, S. Lindsay, 1997 .

The Human genome

T. Strachan, 2003 .

Complete nucleotide sequence of a gene encoding a functional human class I histocompatibility antigen (HLA‐CW3).

T. Strachan, R. Sodoyer, B. Jordan, 1984, The EMBO journal.

Complete nucleotide sequence of a functional class I HLA gene, HLA‐A3: implications for the evolution of HLA genes.

T. Strachan, R. Sodoyer, B. Jordan, 1984, The EMBO journal.

Modes and rates of change of complex DNA families of Drosophila.

T. Strachan, E. Coen, G. Dover, 1982, Journal of molecular biology.

Molecular genetics of congenital adrenal hyperplasia

T. Strachan, 1989, Trends in Endocrinology & Metabolism.

Human embryo use in developmental research

T. Strachan, J. Burn, 1995, Nature Genetics.

Genetic and physical mapping at the limb-girdle muscular dystrophy locus (LGMD2B) on chromosome 2p.

J. Weissenbach, D. Le Paslier, K. Bushby, 1996, Genomics.

Mapping of HLA epitopes recognized by H-2-restricted cytotoxic T lymphocytes specific for HLA using recombinant genes and synthetic peptides.

T. Strachan, R. Sodoyer, B. Jordan, 1988, Journal of immunology.

Eleven novel mutations in the NF2 tumour suppressor gene

T. Strachan, D. Bourn, S. Tekeş, 1995, Human Genetics.

DNA Structure and Gene Expression

T. Strachan, A. Read, 1999 .

Main clinical features of the three mapped autosomal recessive limb-girdle muscular dystrophies and estimated proportion of each form in 13 Brazilian families.

K. Bushby, T. Strachan, M. Passos-Bueno, 1996, Journal of medical genetics.

Genesis by meiotic unequal crossover of a de novo deletion that contributes to steroid 21-hydroxylase deficiency.

T. Strachan, C. Costigan, P. Sinnott, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Corrigendum: A de novo pathological point mutation at the 21–hydroxylase locus: implications for gene conversion in the human genome

M. Tassabehji, T. Strachan, S. Collier, 1993, Nature Genetics.

Basic principles of nucleic acid structure and gene expression

T. Strachan, A. Read, 2018, Human Molecular Genetics.

Transition stages of molecular drive in multiple‐copy DNA families in Drosophila

T. Strachan, G. Dover, D. Webb, 1985, The EMBO journal.

The molecular biology of LGMD2B — Towards the identification of the LGMD gene on chromosome 2p13

K. Bushby, T. Strachan, M. Passos-Bueno, 1996, Neuromuscular Disorders.

Towards effective and rewarding data sharing

Anders M. Dale, Arthur W. Toga, Stephen T. C. Wong, 2003, Neuroinformatics.

A gene for pachyonychia congenita is closely linked to the keratin gene cluster on 17q12-q21.

T. Strachan, J. Rees, C. Munro, 1994, Journal of medical genetics.

A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A

M. Stojkovic, M. Lako, T. Strachan, 2009, The Journal of cell biology.

Analysis of the human Sonic Hedgehog coding and promoter regions in sacral agenesis, triphalangeal thumb, and mirror polydactyly

S. Scherer, L. Tsui, S. Antonarakis, 1998, Human Genetics.

Restriction fragment length polymorphism at the HLA-C locus

T. Strachan, C. W. Summers, Rodney Harris, 2004, Immunogenetics.

Transcription of HLA-G transgenes commences shortly after implantation during embryonic development in mice.

T. Strachan, A. Mellor, A. Horuzsko, 1994, Immunology.

A genetic study of type 2 neurofibromatosis in the United Kingdom. I. Prevalence, mutation rate, fitness, and confirmation of maternal transmission effect on severity.

T. Strachan, S. Huson, R. Ramsden, 1992, Journal of medical genetics.