N. Morgan

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Changing perspectives on the progression of type 1 diabetes

N. Morgan, S. Richardson, 2016 .

Offspring of Mice Exposed to a Low-Protein Diet in Utero Demonstrate Changes in mTOR Signaling in Pancreatic Islets of Langerhans, Associated with Altered Glucagon and Insulin Expression and a Lower β-Cell Mass

N. Morgan, S. Richardson, Yuzhen Tong, 2019, Nutrients.

Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes

Å. Lernmark, J. Dunne, N. Morgan, 2019, Diabetologia.

Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells.

N. Morgan, S. Richardson, J. Nyalwidhe, 2016, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells

N. Morgan, S. Richardson, P. Marchetti, 2020, Nature Communications.

Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion

P. MacDonald, N. Morgan, S. Richardson, 2020, Cell reports.

Vitamin D-binding protein is required for the maintenance of α-cell function and glucagon secretion

P. MacDonald, N. Morgan, S. Richardson, 2019, bioRxiv.

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction

N. Morgan, S. Richardson, P. Marchetti, 2018, EBioMedicine.

Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes.

Peter S. Linsley, Sarah J. Richardson, Francesco Dotta, 2018, JCI insight.

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

Mark S. Anderson, P. Bingley, M. Knip, 2019, Diabetes Care.

Fifty years of pancreatic islet pathology in human type 1 diabetes: insights gained and progress made

N. Morgan, S. Richardson, 2018, Diabetologia.

Evidence for the involvement of cGMP and protein kinase G in nitric oxide‐induced apoptosis in the pancreatic B‐cell line, HIT‐T15

N. Morgan, G. Williams, G.T. Williams, 1997, FEBS letters.

Siglec-7 restores β-cell function and survival and reduces inflammation in diabetic pancreatic islets

A. Varki, N. Morgan, G. Dharmadhikari, 2017 .

Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients

J. Kieswich, M. Yaqoob, N. Morgan, 2013, Diabetologia.

Differential regulation of the ER stress response by long-chain fatty acids in the pancreatic beta-cell.

N. Morgan, Eleftheria Diakogiannaki, 2008, Biochemical Society transactions.

The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor

N. Morgan, S. Richardson, M. A. Russell, 2015, Diabetologia.

Characterization of the Imidazoline Binding Site Involved in Regulation of Insulin Secretion fn1

N. Morgan, C. A. Brown, S. Chan, 1995, Annals of the New York Academy of Sciences.

Antagonism of the stimulatory effects of efaroxan and glibenclamide in rat pancreatic islets by the imidazoline, RX801080

N. Morgan, Stephen A. Smith, M. Stillings, 1993, British journal of pharmacology.

Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter]

N. Morgan, S. Richardson, M. A. Russell, 2014, Diabetologia.

Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids.

N. Morgan, H. Welters, Eleftheria Diakogiannaki, 2008, The Journal of endocrinology.

Targeting surface voids to counter membrane disorders in lipointoxication-related diseases

N. Morgan, B. Antonny, Lydie Vamparys, 2016, Journal of Cell Science.

Structural requirements for the cytoprotective actions of mono‐unsaturated fatty acids in the pancreatic β‐cell line, BRIN‐BD11

N. Morgan, H. Welters, S. Dhayal, 2008, British journal of pharmacology.

Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic β-cells

P. Calder, N. Morgan, C. Childs, 2007, The Journal of endocrinology.

Life and death decisions of the pancreatic β-cell: the role of fatty acids

N. Morgan, P. Newsholme, H. Welters, 2007 .

Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic β-cells

P. Calder, N. Morgan, C. Childs, 2007, The Journal of endocrinology.

Evidence that a STAT3 Mutation Causing Hyper IgE Syndrome Leads to Repression of Transcriptional Activity

Lorena E. Lorenzo, N. Morgan, M. A. Russell, 2019, Case reports in immunology.

Expression of CD47 in the pancreatic β‐cells of people with recent‐onset type 1 diabetes varies according to disease endotype

N. Morgan, S. Richardson, M. A. Russell, 2021, Diabetic medicine : a journal of the British Diabetic Association.

The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes

N. Morgan, S. Richardson, M. A. Russell, 2018, Diabetologia.

The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes

N. Morgan, S. Richardson, M. A. Russell, 2018, Diabetologia.

Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process.

N. Morgan, Susan L.F. Chan, D. Jackson, 2006, Biochemical and biophysical research communications.

C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase

B. Shields, A. Hattersley, N. Morgan, 2018, Diabetes Care.

The impact of anti-inflammatory cytokines on the pancreatic β-cell

N. Morgan, M. A. Russell, M. Russell, 2014, Islets.

Dysregulation of Hnf1b gene expression in cultured beta-cells in response to cytotoxic fatty acid.

L. Harries, N. Morgan, Eleftheria Diakogiannaki, 2011, JOP : Journal of the pancreas.

The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic beta-cells.

N. Morgan, H. Welters, Eleftheria Diakogiannaki, 2008, Biochemical Society transactions.

Sigma receptor ligands and imidazoline secretagogues mediate their insulin secretory effects by activating distinct receptor systems in isolated islets.

N. Morgan, S. Chan, 1998, European journal of pharmacology.

Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells.

A. Hattersley, L. Harries, N. Morgan, 2006, The Journal of endocrinology.

Effects of tyrosine kinase inhibitors on cell death induced by sodium fluoride and pertussis toxin in the pancreatic β‐cell line, RINm5F

N. Morgan, J. Scarpello, J. Elliott, 2001 .

Spatiotemporal Dynamics of Insulitis in Human Type 1 Diabetes

N. Morgan, S. Richardson, K. Tsaneva-Atanasova, 2016, Front. Physiol..

Superoxide, nitric oxide, peroxynitrite and cytokine combinations all cause functional impairment and morphological changes in rat islets of Langerhans and insulin secreting cell lines, but dictate cell death by different mechanisms

N. Morgan, J. Mabley, J. Thorpe, 2004, Apoptosis.

Bringing the human pancreas into focus: new paradigms for the understanding of Type 1 diabetes

N. Morgan, Noel G. Morgan, 2017, Diabetic medicine : a journal of the British Diabetic Association.

The Beneficial Effects of n-3 Polyunsaturated Fatty Acids on Diet Induced Obesity and Impaired Glucose Control Do Not Require Gpr120

N. Morgan, M. Bohlooly-y, Mikael Bjursell, 2014, PloS one.

Characterisation of the α1-adrenergic control of hepatic cAMP in male rats

N. Morgan, J. Exton, L. E. Waynick, 1983 .

Expression and functional activity of PPAR c in pancreatic b cells 1

N. Morgan, Stephen A. Smith, S. McBain, 2004 .

G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell.

N. Morgan, S. Dhayal, 2009, Biochemical pharmacology.

Characterisation of new efaroxan derivatives for use in purification of imidazoline-binding sites.

C. A. Ramsden, N. Morgan, J. Chapman, 1998, European journal of pharmacology.

Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes

N. Morgan, S. Richardson, A. Foulis, 2010, Diabetologia.

The prevalence of enteroviral vp 1 immunostaining in pancreatic islets in human type 1 diabetes

N. Morgan, S. Richardson, A. Foulis, 2009 .

Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways.

N. Morgan, A. Kaminski, H. Welters, 2009, Bioscience reports.

Islet-associated macrophages in type 2 diabetes

N. Morgan, S. Richardson, A. Foulis, 2009, Diabetologia.

Regulation of insulin secretion by a2-adrenergic agonists

N. Morgan, 1987 .

N. Morgan, P. Blackmore, J. Exton, 1983, The Journal of biological chemistry.

Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line

N. Morgan, R. Curi, P. Newsholme, 2010, Clinical science.

Differential effects of genistein on apoptosis induced by fluoride and pertussis toxin in human and rat pancreatic islets and RINm5F cells.

N. Morgan, J. Scarpello, J. Elliott, 2002, The Journal of endocrinology.

Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns

L. Harries, N. Morgan, S. Richardson, 2019, Human molecular genetics.

The significance of GPR119 agonists as a future treatment for type 2 diabetes.

N. Morgan, S. Dhayal, 2010, Drug news & perspectives.

Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation.

N. Morgan, G. Williams, R. James, 1998, Diabetes.

Phosphorylcholine-Containing Polymers for Use in Cell Encapsulation

N. Morgan, Ying Yang, A. E. El Haj, 2004, Artificial cells, blood substitutes, and immobilization biotechnology.

Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children

N. Morgan, S. Richardson, J. Berthelsen, 2012, Diabetologia.

Life and death decisions of the pancreatic beta-cell: the role of fatty acids.

N. Morgan, P. Newsholme, H. Welters, 2007, Clinical science.

A Kir6.2 Mutation Causing Neonatal Diabetes Impairs Electrical Activity and Insulin Secretion From INS-1 β-Cells

F. Ashcroft, A. Hattersley, N. Morgan, 2006, Diabetes.

Germinal centre frequency is decreased in pancreatic lymph nodes from individuals with recent-onset type 1 diabetes

N. Morgan, S. Richardson, S. Kent, 2017, Diabetologia.

Footprints of Immune Cells in the Pancreas in Type 1 Diabetes; to “B” or Not to “B”: Is That Still the Question?

N. Morgan, P. Leete, 2021, Frontiers in Endocrinology.

Ac ce pt ed M an us cr ip t G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta cell

N. Morgan, S. Dhayal, 2017 .

Differential Expression of α2-Adrenoceptor Subtypes in Purified Rat Pancreatic Islet A- and B-Cells

N. Morgan, C. Perrett, Susan L.F. Chan, 1997 .

Selective stimulation of glucagon secretion by β2‐adrenoceptors in isolated islets of Langerhans of the rat

N. Morgan, N. Berrow, J. Scarpello, 1991, British journal of pharmacology.

Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic β-cells exposed to palmitate

N. Morgan, Stephen A. Smith, M. Tadayyon, 2006, Apoptosis.

Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells.

N. Morgan, M. Tadayyon, S. Smith, 2004, Journal of molecular endocrinology.

Functional effects of expression of wolframin-antisense transcripts in BRIN-BD11 beta-cells.

N. Morgan, S. McBain, 2003, Biochemical and biophysical research communications.

A specific inhibitor of cytosolic phospholipase A2 activity, AACOCF3, inhibits glucose-induced insulin secretion from isolated rat islets.

N. Morgan, J. Scarpello, A. C. Loweth, 1996, Biochemical and biophysical research communications.

Down-regulation of proliferation does not affect the secretory function of transformed β-cell lines regardless of their anatomical configuration

Peter M. Jones, N. Morgan, S. Persaud, 2011, Islets.

Pharmacological characterization of the cytoprotective effects of polyunsaturated fatty acids in insulin‐secreting BRIN‐BD11 cells

N. Morgan, S. Dhayal, 2011, British journal of pharmacology.

Differential routing and disposition of the long-chain saturated fatty acid palmitate in rodent vs human beta-cells

N. Morgan, Christian Hacker, C. Arden, 2022, Nutrition & Diabetes.

Heterotrimeric G-proteins are implicated in the regulation of apoptosis in pancreatic beta-cells.

N. Morgan, G. Williams, J. Scarpello, 1996, Experimental cell research.

An Activating STAT 3 Muta tion Causes Neonatal Diabetes through Premature Induction of Pancreatic

N. Morgan, R. D. Hawkins, M. Varjosalo, 2022 .

Unsaturated fatty acids as cytoprotective agents in the pancreatic beta-cell.

N. Morgan, S. Dhayal, 2010, Prostaglandins, leukotrienes, and essential fatty acids.

Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1

N. Morgan, S. Richardson, A. Foulis, 2012, Diabetologia.

Pre‐incubation with interleukin‐4 mediates a direct protective effect against the loss of pancreatic β‐cell viability induced by proinflammatory cytokines

N. Morgan, A. Kaminski, E. Kaminski, 2007, Clinical and experimental immunology.

Characterisation of the alpha 1-adrenergic control of hepatic cAMP in male rats.

N. Morgan, J. Exton, L. E. Waynick, 1983, European journal of pharmacology.

Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans.

N. Morgan, A. Hudson, C. Parker, 2003, European journal of pharmacology.

Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter]

J. Dunne, N. Morgan, S. Richardson, 2019, Diabetologia.

The α2-adrenoceptor antagonist efaroxan modulates K+ATP channels in insulin-secreting cells

N. Morgan, M. Stillings, M. Dunne, 1991 .

Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes

N. Morgan, S. Richardson, I. Salmon, 2012, Diabetologia.

Structure–activity relationships influencing lipid‐induced changes in eIF2α phosphorylation and cell viability in BRIN‐BD11 cells

N. Morgan, S. Dhayal, 2011, FEBS letters.

Identification and characterisation of tertiary lymphoid organs in human type 1 diabetes

N. Morgan, S. Richardson, F. Arfuso, 2021, Diabetologia.

Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan.

N. Morgan, S. Chan, M. Mourtada, 2001, Diabetes.

Long-chain saturated fatty acid species are not toxic to human pancreatic β-cells and may offer protection against pro-inflammatory cytokine induced β-cell death

N. Morgan, H. Welters, Patricia Thomas, 2020, Nutrition & Metabolism.

Phospholipase A2 expression in human and rodent insulin-secreting cells

N. Morgan, J. Scarpello, A. C. Loweth, 1995, Molecular and Cellular Endocrinology.

Studies on the mechanism of inhibition of hepatic cAMP accumulation by vasopressin

N. Morgan, J. Exton, C. Shipp, 1983, FEBS letters.

Studies on the role of inositol trisphosphate in the regulation of insulin secretion from isolated rat islets of Langerhans.

N. Morgan, W. Montague, G. Rumford, 1985, The Biochemical journal.

Evidence that protein kinase C (cid:1) is not required for palmitate-induced cytotoxicity in BRIN-BD11 (cid:2) -cells

N. Morgan, M. Tadayyon, S. Smith, 2004 .

The effect of staphylococcal δ-haemolysin on the secretory activity of the pancreatic β-cell

N. Morgan, W. Montague, A. Fitzhugh, 1981, Bioscience reports.

Multiple effector pathways regulate the insulin secretory response to the imidazoline RX871024 in isolated rat pancreatic islets

N. Morgan, Stephen A. Smith, S. Smith, 1999, British journal of pharmacology.

Involvement of the cGMP signalling pathway in the regulation of viability in insulin‐secreting BRIN‐BD11 cells

N. Morgan, Hongwei Gao, A. Kaminski, 2004, FEBS letters.

Dissociation between Fas expression and induction of apoptosis in human islets of Langerhans

N. Morgan, G. Williams, S. McBain, 2000, Diabetes, obesity & metabolism.

Upregulation of HLA class I and Antiviral Tissue Responses in Hashimoto's Thyroiditis.

N. Morgan, S. Richardson, K. Dahl-Jørgensen, 2020, Thyroid : official journal of the American Thyroid Association.

Extraction of active clonidine-displacing substance from bovine lung and comparison with clonidine-displacing substance extracted from other tissues.

M. P. Dillon, D. Nutt, N. Morgan, 1999, European journal of pharmacology.

Clotrimazole and efaroxan stimulate insulin secretion by different mechanisms in rat pancreatic islets

N. Morgan, A. L. Pallett, Susan L.F. Chan, 1997, Naunyn-Schmiedeberg's Archives of Pharmacology.

The effect of the putative endogenous imidazoline receptor ligand, clonidine‐displacing substance, on insulin secretion from rat and human islets of Langerhans

N. Morgan, D. Atlas, R. James, 1997, British journal of pharmacology.

The imidazoline site involved in control of insulin secretion: characteristics that distinguish it from I1‐ and I2‐sites

N. Morgan, Susan L.F. Chan, Colin A. Brown, 1994, British journal of pharmacology.

Effects of imidazoline binding site ligands on the growth and viability of clonal pancreatic β-cells

N. Morgan, S. Smith, J. Elliott, 2000, Naunyn-Schmiedeberg's Archives of Pharmacology.

Conditional expression of hepatocy te nuclear factor-1b, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic b-cells

A. Hattersley, L. Harries, N. Morgan, 2006 .

HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes

D. Harlan, M. Garber, N. Morgan, 2019, Diabetes.

Temporal regulation of interferon signalling in human EndoC-βH1 cells

N. Morgan, S. Richardson, S. Dhayal, 2022, Journal of Molecular Endocrinology.

Islet glutamic acid decarboxylase modified by reactive oxygen species is recognized by antibodies from patients with type 1 diabetes mellitus

N. Morgan, I. Todd, P. Radford, 2001, Clinical and experimental immunology.

Immunological analysis of G-protein expression in the endocrine pancreas.

N. Morgan, I. White, N. Berrow, 1997, Advances in experimental medicine and biology.

Immunoprecipitation of a pertussis toxin substrate of the Go family from rat islets of Langerhans

N. Morgan, N. Berrow, R. Hurst, 1992, Bioscience reports.

Stimulation of insulin secretion by the imidazoline alpha 2-adrenoceptor antagonist efaroxan is mediated by a novel, stereoselective, binding site.

N. Morgan, S. Chan, C. Brown, 1993, European journal of pharmacology.

Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes

N. Morgan, S. Richardson, A. Foulis, 2011, Diabetologia.

Activation of alpha-2-adrenoceptors results in an increase in F-actin formation in HIT-T15 pancreatic B-cells.

N. Morgan, H. Cable, A. El-Mansoury, 1995, The Biochemical journal.

Mechanisms involved in intracellular calcium mobilization in isolated rat islets of Langerhans.

N. Morgan, W. Montague, G. Rumford, 1987, The Biochemical journal.

Insulin Secretagogues with an Imidazoline Structure Inhibit Arginine-Induced Glucagon Secretion from Isolated Rat Islets of Langerhans

N. Morgan, Stephen A. Smith, M. Mourtada, 1997 .

Identification and characterization of non-adrenergic binding sites in insulin-secreting cells with the imidazoline RX821002.

N. Morgan, S. Chan, K. E. Scarpello, 1997, Advances in Experimental Medicine and Biology.

The imidazoline I1 receptor agonist, moxonidine, inhibits insulin secretion from isolated rat islets of Langerhans.

N. Morgan, S. Chan, E. Tsoli, 1995, European journal of pharmacology.

Investigation of the utility of the 1.1B4 cell as a model human beta cell line for study of persistent enteroviral infection

N. Morgan, S. Richardson, Jessica L Hill, 2021, Scientific Reports.

Dissociation between intracellular calcium mobilization and insulin secretion in isolated rat islets of Langerhans

N. Morgan, R. Hurst, R. Hurst, 1988, FEBS letters.

Evidence for differential effects of noradrenaline and somatostatin on intracellular messenger systems in rat islets of Langerhans.

N. Morgan, R. Hurst, 1990, Journal of molecular endocrinology.

Viruses in the Human Pancreas

N. Morgan, S. Richardson, A. Foulis, 2013 .

Preparation of novel 2-(benzo[b]furan-2-yl)-1H-imidazolines for photoaffinity labelling and affinity isolation of imidazoline binding

C. A. Ramsden, N. Morgan, Proteins J. Clews, 2001 .

The cytoprotective effects of oleoylethanolamide in insulin‐secreting cells do not require activation of GPR119

N. Morgan, David M. Smith, C. Lenaghan, 2012, British journal of pharmacology.

Inhalation of glutamic acid decarboxylase 65‐derived peptides can protect against recurrent autoimmune but not alloimmune responses in the non‐obese diabetic mouse

N. Morgan, P. Mathieson, R. Ravanan, 2007, Clinical and experimental immunology.

Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas

N. Morgan, S. Richardson, D. Hober, 2013, Diabetologia.

Use of antisera directed against dsRNA to detect viral infections in formalin-fixed paraffin-embedded tissue.

N. Morgan, S. Richardson, S. Tauriainen, 2010, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

The incubation and monitoring of cell viability in primary rat islets of Langerhans and pancreatic beta-cell lines.

N. Morgan, Eleftheria Diakogiannaki, M. Russell, 2009, Methods in molecular biology.

Stimulation of hepatic glycogenolysis by alpha 1- and beta 2-adrenergic agonists. Evidence against short term agonist-induced desensitization of the responses.

N. Morgan, P. Blackmore, J. Exton, 1982, The Journal of biological chemistry.

Studies on the mechanism by which melittin stimulates insulin secretion from isolated rat islets of Langerhans.

N. Morgan, W. Montague, G. Rumford, 1985, Biochimica et Biophysica Acta.

Effect of glucose on polyphosphoinositide metabolism in isolated rat islets of Langerhans.

N. Morgan, C. A. Prince, W. Montague, 1985, The Biochemical journal.

Effects of noradrenaline on45Ca2+ efflux from isolated rat islets of Langerhans

N. Morgan, W. Montague, G. Rumford, 1985, Bioscience reports.

Evidence that the presence of arginine can lead to overestimation of glucagon levels measured by radioimmunoassay.

N. Morgan, J. Scarpello, R. J. Lacey, 1992, Clinica chimica acta; international journal of clinical chemistry.

Differential expression of alpha 2-adrenoceptor subtypes in purified rat pancreatic islet A- and B-cells.

N. Morgan, C. Perrett, S. Chan, 1997, Cellular signalling.

Effect of the new imidazoline derivative S-22068 (PMS 847) on insulin secretion in vitro and glucose turnover in vivo in rats.

N. Morgan, P. Renard, B. Pfeiffer, 1999, European journal of pharmacology.

Effector systems involved in the insulin secretory responses to efaroxan and RX871024 in rat islets of Langerhans.

N. Morgan, S. Smith, M. Mourtada, 1998, European journal of pharmacology.

Preparation of the I3 Imidazoline Receptor Antagonist KU14R and Related 2,3-Dihydrobenzo[b]furan Derivatives

C. A. Ramsden, N. Morgan, J. Clews, 2004 .

Imidazolines and Pancreatic Hormone Secretion a

C. A. Ramsden, N. Morgan, S. Chan, 1999, Annals of the New York Academy of Sciences.

Imidazoline receptors: new targets for antihyperglycaemic drugs.

N. Morgan, 1999, Expert opinion on investigational drugs.

Characterization of monoamine oxidase isoforms in human islets of Langerhans.

N. Morgan, A. Parini, N. Pizzinat, 1999, Life sciences.

Stimulation of insulin secretion from isolated rat islets of Langerhans by melittin

N. Morgan, W. Montague, William Montague, 1984, Bioscience reports.

Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes

N. Morgan, S. Richardson, M. Peakman, 2018, Diabetes.

Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis

A. Hattersley, S. Ellard, L. Harries, 2010, Proceedings of the National Academy of Sciences.

'Seeing through a glass darkly': casting light on imidazoline 'I' sites.

M. P. Dillon, D. Nutt, N. Morgan, 1998, Trends in pharmacological sciences.

Potentiation of alpha 1-adrenergic responses in rat liver by a cAMP-dependent mechanism.

N. Morgan, P. Blackmore, J. Exton, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

N. Morgan, S. Richardson, C. Mathews, 2016, Diabetologia.

GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans

N. Morgan, Xiufeng Xu, M. Hammar, 2014, Diabetologia.

Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis

B. Shields, A. Hattersley, N. Morgan, 2020, Diabetologia.

The protein tyrosine phosphatase-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway.

N. Morgan, G. Ryffel, K. S. Erdmann, 2008, The Journal of endocrinology.

Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes

A. Varki, N. Morgan, G. Dharmadhikari, 2017, Scientific Reports.

Detection of enterovirus protein and RNA in multiple tissues from nPOD organ donors with type 1 diabetes

N. Morgan, S. Richardson, H. Hyöty, 2018, bioRxiv.

The Achilles heel of pancreatic beta cells in Type 1 Diabetes

N. Morgan, S. Richardson, D. Eizirik, 2016 .

Effects of phenoxybenzamine on insulin secretion from isolated rat islets of Langerhans

N. Morgan, S. Chan, 1989, Bioscience Reports.

Effects of α-adrenergic antagonists on insulin secretion from rat pancreatic islets

N. Morgan, R. Hurst, S. Chan, 1988 .

Imidazoleacetic acid-ribotide: an endogenous ligand that stimulates imidazol(in)e receptors.

P. Ernsberger, N. Morgan, G. Holstein, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?

N. Morgan, S. Richardson, 2014, Trends in Endocrinology & Metabolism.

Detection of a Low-Grade Enteroviral Infection in the Islets of Langerhans of Living Patients Newly Diagnosed With Type 1 Diabetes

N. Morgan, S. Richardson, B. Edwin, 2014, Diabetes.

Induction of an Antiviral State and Attenuated Coxsackievirus Replication in Type III Interferon-Treated Primary Human Pancreatic Islets

N. Morgan, S. Richardson, O. Korsgren, 2013, Journal of Virology.

The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes

N. Morgan, S. Richardson, A. Foulis, 2009, Diabetologia.

Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells

N. Morgan, S. Richardson, D. Eizirik, 2015, eLife.

HLA Class I Upregulation and Antiviral Immune Responses in Graves Disease

N. Morgan, S. Richardson, K. Dahl-Jørgensen, 2020, The Journal of clinical endocrinology and metabolism.

An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection.

B. Wagner, N. Morgan, S. Richardson, 2016, ACS chemical biology.

Type 1 Diabetes: Interferons and the Aftermath of Pancreatic Beta-Cell Enteroviral Infection

N. Morgan, S. Richardson, P. Akhbari, 2020, Microorganisms.

Enteroviral infections in the pathogenesis of type 1 diabetes: new insights for therapeutic intervention

N. Morgan, S. Richardson, 2018, Current opinion in pharmacology.

Treatment of cultured pancreatic B-cells with streptozotocin induces cell death by apoptosis

N. Morgan, Gwyn T. Williams, H. Cable, 1994, Bioscience reports.

Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease

J. Kere, A. Hattersley, Å. Lernmark, 2014, Nature Genetics.

Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes

N. Morgan, S. Richardson, W. Qian, 2021, Diabetes.

Pancreatic β‐Cells Express an Imidazoline Binding Site That Is Distinct from I1 and I2 Sites fn1

N. Morgan, Colin A. Brown, K. E. Scarpello, 1995 .

Pancreatic beta-cells express an imidazoline binding site that is distinct from I1 and I2 sites.

N. Morgan, C. A. Brown, S. Chan, 1995, Annals of the New York Academy of Sciences.

Pancreatic Pathology in Type 1 Diabetes Mellitus

N. Morgan, S. Richardson, A. Foulis, 2014, Endocrine Pathology.

A novel disease mechanism leading to the expression of a disallowed gene in the pancreatic beta-cell identified by non-coding, regulatory mutations controlling HK1

M. Weedon, A. Hattersley, S. Ellard, 2021, medRxiv.

Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic β-cells

N. Morgan, S. Dhayal, A. Cooper, 2013, Islets.

Effects of the imidazoline binding site ligands, idazoxan and efaroxan, on the viability of insulin-secreting BRIN-BD11 cells.

N. Morgan, Hongwei Gao, M. Mourtada, 2003, JOP : Journal of the pancreas.

Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes

N. Morgan, S. Richardson, K. Dahl-Jørgensen, 2016, Diabetes.

35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts.

Thomas J. Smith, B. M. Rasmussen, V. C. Phan, 1999, Diabetologia.

Imidazoline binding sites in the endocrine pancreas: can they fulfil their potential as targets for the development of new insulin secretagogues?

N. Morgan, S. Chan, S. Chan, 2001, Current pharmaceutical design.

The putative imidazoline receptor agonist, harmane, promotes intracellular calcium mobilisation in pancreatic beta-cells.

N. Morgan, G. Rogers, P. Squires, 2004, European journal of pharmacology.

Identification of the monomeric G‐protein, Rhes, as an efaroxan‐regulated protein in the pancreatic β‐cell

N. Morgan, Hongwei Gao, S. Chan, 2002, British journal of pharmacology.

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation.

N. Morgan, R. D. Hawkins, M. Varjosalo, 2017, Cell reports.

Characterization of RFs in TLOS of NOD mice. We conducted an in-depth characterization of the RFs in TLOs of NOD mice using a broad repertoire of antibodies directed against specific BM and interstitial matrix (IM) components

N. Morgan, S. Richardson, F. Arfuso, 2021 .

Modulation of the alpha 1-adrenergic control of hepatocyte calcium redistribution by increases in cyclic AMP.

N. Morgan, P. Blackmore, J. Exton, 1983, The Journal of biological chemistry.

How, When, and Where Do Human β-Cells Regenerate?

N. Morgan, R. Kulkarni, G. Basile, 2019, Current Diabetes Reports.

Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?

B. Giepmans, N. Morgan, S. Richardson, 2017, Diabetologia.

The diagnosis of insulitis in human type 1 diabetes

B. Giepmans, N. Morgan, S. Richardson, 2013, Diabetologia.

Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells

N. Morgan, S. Richardson, D. Eizirik, 2018, Diabetologia.

Abnormal islet sphingolipid metabolism in type 1 diabetes

F. Pociot, N. Morgan, C. Mathews, 2018, Diabetologia.

Mono‐unsaturated fatty acids protect against β‐cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure

N. Morgan, Stephen A. Smith, M. Tadayyon, 2004, FEBS letters.

Conditional expression of the FTO gene product in rat INS-1 cells reveals its rapid turnover and a role in the profile of glucose-induced insulin secretion.

N. Morgan, M. Russell, 2011, Clinical science.

Activation of Protein Kinase C Modulates α2-Adrenergic Signalling in Rat Pancreatic Islets

N. Morgan, A. El-Mansoury, 1998 .

GTP-binding proteins in cell survival and demise: the emerging picture in the pancreatic beta-cell.

N. Morgan, A. Kowluru, 2002, Biochemical pharmacology.

Fatty acids and β-cell toxicity

N. Morgan, 2009, Current opinion in clinical nutrition and metabolic care.

Stimulation of insulin secretion by efaroxan may involve interaction with potassium channels.

N. Morgan, S. Chan, S. Chan, 1990, European journal of pharmacology.

Interactions between imidazoline compounds and sulphonylureas in the regulation of insulin secretion

N. Morgan, Stephen A. Smith, V. Piercy, 1997, British journal of pharmacology.

Section Review: Oncologic, Endocrine and Metabolic Adrenoceptors and imidazoline binding sites in the endocrine pancreas as targets for anti-hyperglycaemic drugs

N. Morgan, 1994 .

Stimulation of insulin secretion by imidazoline compounds is not due to interaction with non‐adrenoceptor idazoxan binding sites

N. Morgan, Stephen A. Smith, A. C. Loweth, 1993, British journal of pharmacology.

Mechanisms involved in stimulation of insulin secretion by the hypoglycaemic alpha-adrenergic antagonist, DG-5128.

N. Morgan, M. Stillings, S. Chan, 1991, Biochemical and biophysical research communications.

Concentration-dependent effects of adrenaline on the profile of insulin secretion from isolated human islets of Langerhans.

N. Morgan, R. James, N. London, 1993, The Journal of endocrinology.

Differential effects of β-adrenergic agonists on insulin secretion from pancreatic islets isolated from rat and man

N. Morgan, N. Berrow, R. James, 1990 .

Evidence that the ability of imidazoline compounds to stimulate insulin secretion is not due to interaction with sigma receptors.

C. A. Ramsden, N. Morgan, A. L. Pallett, 1997, European journal of pharmacology.

Studies on the mechanism of inhibition of glucose-stimulated insulin secretion by noradrenaline in rat islets of Langerhans.

N. Morgan, W. Montague, 1985, The Biochemical journal.

The alpha 2-adrenoceptor antagonist efaroxan modulates K+ATP channels in insulin-secreting cells.

N. Morgan, M. Stillings, M. Dunne, 1991, European Journal of Pharmacology.

Preparation of Analogues of Efaroxan and KU14R as Potential Imidazoline Receptor Subtype 3 Ligands

C. A. Ramsden, N. Morgan, Richard D. Farn, 2008 .

Imidazoline Receptors and their Ligands as Potentiators of Nutrient-Induced Insulin Secretion

N. Morgan, S. Chan, 2004 .

Comparative Effects of Efaroxan and b‐Carbolines on the Secretory Activity of Rodent and Human b Cells

N. Morgan, A. Hudson, C. Parker, 2003, Annals of the New York Academy of Sciences.

Preparation of Analogues of Efaroxan and KU14R as Potential Imidazoline Receptor Subtype 3 Ligands.

C. A. Ramsden, N. Morgan, Richard D. Farn, 2008 .

Pseudoislets as primary islet replacements for research

N. Morgan, T. Maffucci, M. D. Turner, 2010, Islets.

Immunopathology of the human pancreas in type-I diabetes

N. Morgan, S. Richardson, A. Foulis, 2011, Seminars in Immunopathology.

Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes.

A. Hattersley, S. Ellard, L. Harries, 2006, Human molecular genetics.

An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells

N. Morgan, S. Richardson, P. Marchetti, 2020, Nature Communications.

Reduced expression of the co-regulator TLE1 in type 2 diabetes is associated with increased islet α-cell number.

P. MacDonald, N. Krasnogor, N. Morgan, 2020, Endocrinology.

Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes

N. Morgan, S. Richardson, E. D. de Koning, 2017, Oncotarget.

Serotype specificity and utility of antibodies 5D8/1 and Cox mAB 31A2 for enterovirus diagnostics

N. Morgan, S. Richardson, H. Hyoty, 2022, medRxiv.

Intracellular events responsible for the inhibition of insulin secretion by somatostatin.

N. Morgan, R. Hurst, 1989, Biochemical Society transactions.

The inducible β5i proteasome subunit contributes to proinsulin degradation in GRP94 deficient β cells and is overexpressed in type 2 diabetes pancreatic islets.

N. Morgan, S. Richardson, B. Tyrberg, 2020, American journal of physiology. Endocrinology and metabolism.

A novel de novo activating mutation in STAT3 identified in a patient with common variable immunodeficiency (CVID).

D. Kelsell, N. Morgan, H. Longhurst, 2017, Clinical immunology.

Studies on the interaction of staphylococcal delta-haemolysin with isolated islets of Langerhans.

N. Morgan, W. Montague, 1982, The Biochemical journal.

Monogenic Early-Onset Lymphoproliferation and Autoimmunity: The Natural History of STAT3 GOF Syndrome.

K. Schwarz, M. Weinrich, F. Rieux-Laucat, 2022, The Journal of allergy and clinical immunology.

Expression and functional activity of PPARγ in pancreatic β cells

N. Morgan, Stephen A. Smith, S. McBain, 2004, British journal of pharmacology.

In situ analysis reveals that CFTR is expressed in only a small minority of β-cells in normal adult human pancreas.

N. Krasnogor, N. Morgan, S. Richardson, 2019, The Journal of clinical endocrinology and metabolism.

Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis

A. Hattersley, S. Ellard, L. Harries, 2010, Proceedings of the National Academy of Sciences.

Expression of alpha 2- and beta-adrenoceptor subtypes in human islets of Langerhans.

N. Morgan, R. James, C. Perrett, 1996, The Journal of endocrinology.

Unsaturated fatty acids as cytoprotective agents in the pancreatic beta-cell.

N. Morgan, S. Dhayal, 2010, Prostaglandins, leukotrienes, and essential fatty acids.

Expression and functional roles of guanylate cyclase isoforms in BRIN-BD11 β-cells

N. Morgan, M. Russell, 2010, Islets.