N. Huang

发表

Identification of non-phosphate-containing small molecular weight inhibitors of the tyrosine kinase p56 Lck SH2 domain via in silico screening against the pY + 3 binding site.

Alexander D. MacKerell, N. Huang, A. Nagarsekar, 2004, Journal of medicinal chemistry.

Automated Docking Screens: A Feasibility Study

Michael M. Mysinger, J. Irwin, B. Shoichet, 2009, Journal of medicinal chemistry.

Benchmarking sets for molecular docking.

J. Irwin, B. Shoichet, N. Huang, 2006, Journal of medicinal chemistry.

Protein-facilitated base flipping in DNA by cytosine-5-methyltransferase

Alexander D. MacKerell, Niu Huang, Alexander D MacKerell, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Specificity in protein-DNA interactions: energetic recognition by the (cytosine-C5)-methyltransferase from HhaI.

Alexander D. MacKerell, Niu Huang, Alexander D MacKerell, 2005, Journal of molecular biology.

Exploring the early stages of the pH‐induced conformational change of influenza hemagglutinin

N. Huang, Yu Zhou, Chao Wu, 2014, Proteins.

5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader

Samir Adhikari, Niu Huang, Yun-Gui Yang, 2017, Cell Research.

Molecular mechanics methods for predicting protein-ligand binding.

M. Jacobson, N. Huang, C. Kalyanaraman, 2006, Physical chemistry chemical physics : PCCP.

Structure-Based Discovery of Novel and Selective 5-Hydroxytryptamine 2B Receptor Antagonists for the Treatment of Irritable Bowel Syndrome.

Xi-Ping Huang, N. Huang, Yu Zhou, 2016, Journal of medicinal chemistry.

Automated site preparation in physics‐based rescoring of receptor ligand complexes

M. Jacobson, N. Huang, C. Rapp, 2009, Proteins.

Binding-Site Assessment by Virtual Fragment Screening

M. Jacobson, N. Huang, Niu Huang, 2010, PloS one.

Physics-based methods for studying protein-ligand interactions.

Niu Huang, Matthew P Jacobson, M. Jacobson, 2007, Current opinion in drug discovery & development.

Identifying multiple-target ligands via computational chemogenomics approaches.

Niu Huang, Zongru Guo, N. Huang, 2012, Current topics in medicinal chemistry.

Exploiting ordered waters in molecular docking.

Niu Huang, Brian K Shoichet, B. Shoichet, 2008, Journal of medicinal chemistry.

A motif in LILRB2 critical for Angptl2 binding and activation.

G. Gao, N. Huang, Qihui Wang, 2014, Blood.

HEMATOPOIESIS AND STEM CELLS A motif in LILRB 2 critical for Angptl 2 binding and activation

G. Gao, N. Huang, Qihui Wang, 2014 .

Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.

Samir Adhikari, Niu Huang, Yun-Gui Yang, 2016, Molecular cell.

Chapter 2 Binding Site Druggability Assessment in Fragment-Based Drug Design

N. Huang, Yu Zhou, Niu Huang, 2019 .

Identification of PDE6D as a potential target of sorafenib via PROTAC technology

N. Huang, Xiangbing Qi, Yuting Xie, 2020, bioRxiv.

A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling.

Wei Zhang, Niu Huang, Li Li, 2013, Journal of medicinal chemistry.

Identification of novel inhibitors of BCR-ABL tyrosine kinase via virtual screening.

Chen Xu, Niu Huang, Chunzheng Yang, 2003, Bioorganic & medicinal chemistry letters.

In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery.

Yanli Wang, N. Huang, Xiangbing Qi, 2017, Journal of medicinal chemistry.

Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome

N. Huang, N. Zheng, Hong Lin, 2020, Proceedings of the National Academy of Sciences.

[Computational chemistry in structure-based drug design].

N. Huang, Yu Zhou, Wei Li, 2013, Yao xue xue bao = Acta pharmaceutica Sinica.

Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1.

N. Huang, P. Li, T. Cai, 2019 .

A survey of the role of nitrile groups in protein-ligand interactions.

N. Huang, Yunfei Du, Yuanxun Wang, 2018, Future medicinal chemistry.

Incorporating replacement free energy of binding‐site waters in molecular docking

N. Huang, Lifeng Zhao, S. Peng, 2014, Proteins.

A bacterial type III effector family uses the papain-like hydrolytic activity to arrest the host cell cycle

N. Huang, She Chen, Chengzu Long, 2009, Proceedings of the National Academy of Sciences.

Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1

Liang Wang, N. Huang, J. Qi, 2022, Cell.

Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers

M. Dong, N. Huang, Yue-He Ding, 2019, Nature Communications.

A Fast Lysine Cross-linker DOPA Enables Mass Spectrometry Analyses of Protein Unfolding and Weak Protein-protein Interactions

M. Dong, N. Huang, Y. Zhou, 2020, bioRxiv.

A Review of FoxO1-Regulated Metabolic Diseases and Related Drug Discoveries

N. Huang, S. Peng, Wei Li, 2020, Cells.

CryoEM structure of yeast cytoplasmic exosome complex

M. Dong, N. Huang, Jun-Jie Liu, 2016, Cell Research.

FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis

K. Houk, N. Huang, A. Minami, 2020, Nature Chemistry.

More than just a GPCR ligand: structure-based discovery of thioridazine derivatives as Pim-1 kinase inhibitors

Niu Huang, Li Li, Wei Zhang, 2014 .

Design, synthesis, and bioactivity evaluation of macrocyclic benzo[b]pyrido[4,3-e][1,4]oxazine derivatives as novel Pim-1 kinase inhibitors.

N. Huang, Jiwei Xu, Yu Zhou, 2022, Bioorganic & medicinal chemistry letters.

Exploring Halogen Bonds in 5-Hydroxytryptamine 2B Receptor-Ligand Interactions.

Xi-Ping Huang, N. Huang, Yu Zhou, 2018, ACS medicinal chemistry letters.

Structural and mechanistic insights into the biosynthesis of CDP-archaeol in membranes

Yuquan Wei, Wei Cheng, N. Huang, 2017, Cell Research.

Assessment of the Generalization Abilities of Machine-Learning Scoring Functions for Structure-Based Virtual Screening

N. Huang, Jin-Can Yang, Hui Zhu, 2022, J. Chem. Inf. Model..

Complex Structure of PDE3A–SLFN12 and Structure-based Molecular Glue Design for Apoptosis of Tumor Cells

N. Huang, Xiaodong Wang, Hongwei Wang, 2021 .