G. Greco

发表

2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching.

E. Novellino, K. Klotz, B. Cosimelli, 2005, Journal of medicinal chemistry.

From the pharmacophore to the homology model of the benzodiazepine receptor: the indolyglyoxylamides affair.

E. Novellino, B. Cosimelli, G. Greco, 2012, Current topics in medicinal chemistry.

Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.

E. Novellino, G. Greco, M. Artico, 1998, Journal of medicinal chemistry.

Approaches to Three‐Dimensional Quantitative Structure‐Activity Relationships

Ettore Novellino, Giovanni Greco, E. Novellino, 2007 .

A1 adenosine receptor antagonists, 3‐aryl[1,2,4]triazino[4,3‐a]benzimidazol‐4‐(10H)‐ones (ATBIs) and N‐alkyl and N‐acyl‐(7‐substituted‐2‐phenylimidazo[1,2‐a][1,3,5]triazin‐4‐yl)amines (ITAs): Different recognition of bovine and human binding sites

Ettore Novellino, Sabrina Taliani, Federico Da Settimo, 2004 .

Linking CoMFA and protein homology models of enzyme-inhibitor interactions: an application to non-steroidal aromatase inhibitors.

A. Cavalli, E. Novellino, M. Recanatini, 2000, Bioorganic & medicinal chemistry.

Synthesis, structure-activity relationships, and molecular modeling studies of N-(indol-3-ylglyoxylyl)benzylamine derivatives acting at the benzodiazepine receptor.

E. Novellino, G. Greco, A. Da Settimo, 1996, Journal of medicinal chemistry.

Molecular modelling studies with CCK-B receptor antagonists

E. Novellino, G. Greco, C. Silipo, 1993 .

Identification of novel indole derivatives acting as inhibitors of the Keap1–Nrf2 interaction

E. Novellino, B. Cosimelli, G. Greco, 2019, Journal of enzyme inhibition and medicinal chemistry.

4‐amino‐6‐alkyloxy‐2‐alkylthiopyrimidine derivatives as novel non‐nucleoside agonists for the adenosine A1 receptor

E. Novellino, B. Cosimelli, G. Greco, 2016, Chemical biology & drug design.

Allosteric modulators of human A2B adenosine receptor.

E. Novellino, B. Cosimelli, G. Greco, 2014, Biochimica et biophysica acta.

3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists.

E Novellino, A Lavecchia, E. Novellino, 2001, Journal of medicinal chemistry.

3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: tricyclic heteroaromatic derivatives as a new class of benzodiazepine receptor ligands.

E. Novellino, G. Greco, G. Primofiore, 2000, Journal of medicinal chemistry.

Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.

E Novellino, A Lavecchia, E. Novellino, 2001, Journal of medicinal chemistry.

Modeling of kappa-opioid receptor/agonists interactions using pharmacophore-based and docking simulations.

E Novellino, A Lavecchia, E. Novellino, 2000, Journal of medicinal chemistry.

5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.

E. Novellino, B. Cosimelli, G. Greco, 2007, Journal of medicinal chemistry.

Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors.

Barbara Costa, Ettore Novellino, Luciana Marinelli, 2014, Journal of medicinal chemistry.

Novel irreversible fluorescent probes targeting the 18 kDa translocator protein: synthesis and biological characterization.

E. Novellino, B. Cosimelli, G. Greco, 2010, Journal of medicinal chemistry.

Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific "peripheral-type" benzodiazepine receptor ligands.

E. Novellino, G. Greco, G. Campiani, 1996, Journal of medicinal chemistry.

N,N-dialkyl-2-phenylindol-3-ylglyoxylamides. A new class of potent and selective ligands at the peripheral benzodiazepine receptor.

E. Novellino, G. Greco, G. Primofiore, 2004, Journal of medicinal chemistry.

New fluorescent 2-phenylindolglyoxylamide derivatives as probes targeting the peripheral-type benzodiazepine receptor: design, synthesis, and biological evaluation.

E. Novellino, B. Cosimelli, G. Greco, 2007, Journal of medicinal chemistry.

3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists.

E. Novellino, G. Greco, A. Lavecchia, 2001, Journal of medicinal chemistry.

Synthesis and pharmacological evaluation of a set of N-[2-(alkylamino)ethyl]benzotriazol-X-yl isobutyramides acting as local anesthetics

E. Novellino, P. Grieco, G. Greco, 1996 .

Use of the Hydrophobic Substituent Constant in a Comparative Molecular Field Analysis (CoMFA) on a Set of Anilides Inhibiting the Hill Reaction

E. Novellino, G. Greco, C. Silipo, 1993 .

Novel, highly potent aldose reductase inhibitors: cyano(2-oxo-2,3-dihydroindol-3-yl)acetic acid derivatives.

E. Novellino, G. Greco, A. Lavecchia, 2003, Journal of medicinal chemistry.

5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3, 4-dihydropyrimidin-4(3H)-ones: novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives.

E. Novellino, G. Greco, A. Mai, 1999, Journal of medicinal chemistry.

Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships.

E. Novellino, G. Greco, A. Lavecchia, 2001, Journal of medicinal chemistry.

Novel positive allosteric modulators of A2B adenosine receptor acting as bone mineralisation promoters

G. Greco, F. Da Settimo, S. Taliani, 2020, Journal of enzyme inhibition and medicinal chemistry.

Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity.

A. Bergamini, E. Novellino, G. Greco, 1999, Journal of medicinal chemistry.

Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor.

E. Novellino, B. Cosimelli, G. Greco, 2009, Journal of medicinal chemistry.

Synthesis, structure-activity relationships, and molecular modeling studies of N-(indol-3-ylglyoxylyl)benzylamine derivatives acting at the benzodiazepine receptor.

E. Novellino, G. Greco, A. Da Settimo, 1996, Journal of medicinal chemistry.

A comparative molecular field analysis model for 6-arylpyrrolo[2,1-d] [1,5]benzothiazepines binding selectively to the mitochondrial benzodiazepine receptor.

E. Novellino, G. Greco, G. Campiani, 1994, Journal of medicinal chemistry.

Novel ligands specific for mitochondrial benzodiazepine receptors: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives. Synthesis, structure-activity relationships, and molecular modeling studies.

E. Novellino, G. Greco, G. Campiani, 1994, Journal of medicinal chemistry.

Allosterism vs. Orthosterism: Recent Findings and Future Perspectives on A2B AR Physio-Pathological Implications

G. Greco, F. Da Settimo, S. Taliani, 2021, Frontiers in Pharmacology.

Exploiting the Indole Scaffold to Design Compounds Binding to Different Pharmacological Targets †

E. Novellino, G. Greco, F. Da Settimo, 2020, Molecules.

Modulation of A2B adenosine receptor by 1-Benzyl-3-ketoindole derivatives.

E. Novellino, B. Cosimelli, G. Greco, 2013, European journal of medicinal chemistry.

Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein.

E. Novellino, B. Cosimelli, G. Greco, 2011, European journal of medicinal chemistry.

New pyrrolobenzothiazepine derivatives as molecular probes of the ‘peripheral-type’ benzodiazepine receptor (PBR) binding site

E. Novellino, G. Greco, G. Campiani, 1997 .

Novel Ligands Specific for Mitochondrial Benzodiazepine Receptors: 6- Arylpyrrolo(2,1-d) (1,5)benzothiazepine Derivatives. Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies.

E. Novellino, G. Greco, G. Campiani, 1994 .

Pyrrolobenzothiazepinones and pyrrolobenzoxazepinones: novel and specific non-nucleoside HIV-1 reverse transcriptase inhibitors with antiviral activity.

E. Novellino, G. Greco, G. Campiani, 1996, Journal of medicinal chemistry.

Synthesis, Biological Activity, and SARs of Pyrrolobenzoxazepine Derivatives, a New Class of Specific “Peripheral-Type” Benzodiazepine Receptor Ligands1

E. Novellino, G. Greco, G. Campiani, 1996 .

Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity.

A. Bergamini, E. Novellino, P. Huleatt, 2005, Journal of medicinal chemistry.

A concerted study using binding measurements, X-ray structural data, and molecular modeling on the stereochemical features responsible for the affinity of 6-arylpyrrolo[2,1-d][1,5]benzothiazepines toward mitochondrial benzodiazepine receptors.

E. Novellino, G. Greco, G. Campiani, 1995, Journal of medicinal chemistry.

Structure-based design, synthesis, and biological evaluation of novel pyrrolyl aryl sulfones: HIV-1 non-nucleoside reverse transcriptase inhibitors active at nanomolar concentrations.

E. Novellino, G. Greco, R. Silvestri, 2000, Journal of medicinal chemistry.

p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells.

E. Novellino, B. Cosimelli, G. Greco, 2014, ACS chemical neuroscience.

Refinement of the benzodiazepine receptor site topology by structure-activity relationships of new N-(heteroarylmethyl)indol-3-ylglyoxylamides.

E. Novellino, B. Cosimelli, Marina Ehlardo, 2006, Journal of medicinal chemistry.

Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators.

E. Novellino, B. Cosimelli, G. Greco, 2014, Biochimica et biophysica acta.

Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands.

E. Novellino, B. Cosimelli, G. Greco, 2007, Journal of medicinal chemistry.

N'-Phenylindol-3-ylglyoxylohydrazide derivatives: synthesis, structure-activity relationships, molecular modeling studies, and pharmacological action on brain benzodiazepine receptors.

E. Novellino, G. Greco, A. Da Settimo, 1998, Journal of medicinal chemistry.

Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein.

E. Novellino, G. Greco, F. Da Settimo, 2012, Journal of medicinal chemistry.

Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.

E. Novellino, G. Greco, M. Hamon, 1999, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of antiinflammatory 1-methyl-2-(4-X-benzoyl)imidazole-5-acetic acids

E. Novellino, G. Greco, G. Caliendo, 1994 .

Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis.

E. Novellino, B. Cosimelli, G. Greco, 2008, Journal of medicinal chemistry.

Quantitative structure-activity relationships in a set of thiazolidin -4-ones acting as H1-histamine antagonists.

E. Novellino, P. Grieco, G. Greco, 1995, Journal of receptor and signal transduction research.

Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent.

E Novellino, A. Bergamini, E. Novellino, 2001, Journal of medicinal chemistry.

Synthesis and biological activity of benzotriazole derivatives structurally related to trazodone

E. Novellino, G. Greco, G. Caliendo, 1995 .

Enantiomeric 4-Acylamino-6-alkyloxy-2 Alkylthiopyrimidines As Potential A3 Adenosine Receptor Antagonists: HPLC Chiral Resolution and Absolute Configuration Assignment by a Full Set of Chiroptical Spectroscopy.

E. Novellino, B. Cosimelli, G. Greco, 2016, Chirality.

Spirohydantoin derivatives of thiopyrano[2,3-b]pyridin-4(4H)-one as potent in vitro and in vivo aldose reductase inhibitors.

E. Novellino, G. Greco, A. Lavecchia, 2005, Bioorganic & medicinal chemistry.

Solid-state structure and conformation of (Z)-2-(phenylbenzylidene)-3-quinuclidinone, an intermediate in the synthesis of quinuclidine derivatives

G. Greco, G. Caliendo, C. Pedone, 1994 .

MOLECULAR STRUCTURE AND CONFORMATION OF THE (Z) AND (E) GEOMETRIC ISOMERS OF 2-(2-PHENYLBENZYLIDENE)-3 QUINUCLIDINONE

P. Grieco, G. Greco, G. Caliendo, 1995 .

Solid‐State Structure and Conformation of (Z)‐2‐(Phenylbenzylidene)‐3‐ quinuclidinone, an Intermediate in the Synthesis of Quinuclidine Derivatives.

G. Greco, G. Caliendo, C. Pedone, 1994 .

[1,2,4]Triazino[4,3-a]benzimidazole acetic acid derivatives: a new class of selective aldose reductase inhibitors.

E. Novellino, G. Greco, A. Lavecchia, 2001, Journal of medicinal chemistry.

Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation.

E. Novellino, B. Cosimelli, G. Greco, 2010, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of heteroaryl diketohexenoic and diketobutanoic acids as HIV-1 integrase inhibitors endowed with antiretroviral activity.

Y. Pommier, E. Novellino, G. Greco, 2005, Farmaco.

Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors.

E. Novellino, G. Greco, A. Lavecchia, 2000, Bioorganic & medicinal chemistry.

Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: Synthesis and Biological Evaluation of Novel Quinoxalinylethylpyridylthioureas as Potent Antiviral Agents

A. Bergamini, E. Novellino, G. Greco, 2000, Antiviral chemistry & chemotherapy.

Use of the hydrogen bond potential function in a comparative molecular field analysis (CoMFA) on a set of benzodiazepines

Ki Hwan Kim, Ettore Novellino, Giovanni Greco, 1993, J. Comput. Aided Mol. Des..

Indole derivatives as probes to study the benzodiazepine binding site in GABA receptor complex.

E. Novellino, G. Greco, A. Da Settimo, 1996, Advances in experimental medicine and biology.

Effects of variable selection on CoMFA coefficient contour maps in a set of triazines inhibiting DHFR

G Greco, E Novellino, M Pellecchia, 1994, J. Comput. Aided Mol. Des..

Conformational studies on a synthetic C-terminal fragment of the alpha subunit of G(S) proteins.

E. Novellino, G. Greco, P. Rovero, 2000, Biopolymers.

A Gαs Carboxyl-Terminal Peptide Prevents Gs Activation by the A2A Adenosine Receptor

H. Hamm, E. Novellino, G. Greco, 2000 .

Derivatives of Benzimidazol‐2‐ylquinoline and Benzimidazol‐2‐ylisoquinoline as Selective A1 Adenosine Receptor Antagonists with Stimulant Activity on Human Colon Motility

E. Novellino, B. Cosimelli, G. Greco, 2011, ChemMedChem.

Shape-dependent effects in a series of aromatic nitro compounds acting as mutagenic agents on S. typhimurium TA98.

E Novellino, G Caliendo, V Santagada, 1995, SAR and QSAR in environmental research.

Conformational analysis of the Gαs protein C‐terminal region

E. Novellino, G. Greco, A. D'Ursi, 2002, Journal of peptide science : an official publication of the European Peptide Society.

Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides.

E. Novellino, B. Cosimelli, G. Greco, 2015, Journal of medicinal chemistry.

Novel fluorescent triazinobenzimidazole derivatives as probes for labelling human A1 and A2B adenosine receptor subtypes.

B. Cosimelli, G. Greco, F. Da Settimo, 2018, Bioorganic & medicinal chemistry.

Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists.

E. Novellino, B. Cosimelli, Marina Ehlardo, 2008, Journal of medicinal chemistry.

Studies on enantioselectivity of chiral 4-acetylamino-6-alkyloxy-2-alkylthiopyrimidines acting as antagonists of the human A3 adenosine receptor.

E. Novellino, B. Cosimelli, G. Greco, 2018, MedChemComm.

3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A₂B adenosine receptor antagonists.

E. Novellino, B. Cosimelli, G. Greco, 2012, Journal of medicinal chemistry.

Design of novel nicotinic ligands through 3D database searching.

E. Novellino, G. Greco, K. Varani, 2005, Bioorganic & medicinal chemistry.

Structure—affinity relationship studies on benzotriazole derivatives binding to 5-HT receptor subtypes

E. Novellino, P. Grieco, G. Greco, 1996 .

Use of comparative molecular field analysis and cluster analysis in series design

Ettore Novellino, Caterina Fattorusso, Giovanni Greco, 1995 .

Template for the Design of Highly Selective A 2 B Adenosine Receptor Antagonists

E. Novellino, B. Cosimelli, G. Greco, 2012 .

Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A(1) adenosine receptor antagonists.

E. Novellino, B. Cosimelli, G. Greco, 2002, Journal of medicinal chemistry.

A Critical Review of Recent CoMFA Applications

Ettore Novellino, Giovanni Greco, E. Novellino, 1998 .

Comparative Molecular Field Analysis on a Set of Muscarinic Agonists

Ettore Novellino, Giovanni Greco, Carlo Silipo, 1991 .

Synthesis and neurokinin antagonist activity of 2-benzylidene- and 2-benzyl-3-benzylamino quinuclidines.

G. Greco, G. Caliendo, V. Santagada, 1993, Farmaco.

Study of Benzodiazepines Receptor Sites Using a Combined QSAR‐CoMFA Approach

Ettore Novellino, Giovanni Greco, Carlo Silipo, 1992 .

Computer-aided structure-affinity relationships in a set of piperazine and 3,8-diazabicyclo[3.2.1]octane derivatives binding to the μ-opioid receptor

Daniela Barlocco, Ettore Novellino, Giovanni Greco, 1993, J. Comput. Aided Mol. Des..

Synthesis and antinociceptive activity of peptides related to interleukin‐1β193–195 Lys‐Pro‐Thr

P. Grieco, G. Greco, G. Caliendo, 1996 .

Synthesis and Biological Evaluation of 5H-Indolo [3,2-b][1,5]Benzothiazepine Derivatives, Designed as Conformationally Constrained Analogues of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitor L-737,126

E. Novellino, G. Greco, R. Silvestri, 1998, Antiviral chemistry & chemotherapy.

p 53 Functional Inhibitors Behaving Like Pi fi thrin ‐ β Counteract the Alzheimer Peptide Non-β-amyloid Component E ff ects in Human SH-SY 5 Y Cells

E. Novellino, B. Cosimelli, G. Greco, 2014 .

Carboxyl-Terminal Peptide Prevents Gs Activation by the A 2 A Adenosine Receptor

H. Hamm, E. Novellino, G. Greco, 2000 .