G. Primofiore

发表

2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching.

E. Novellino, K. Klotz, B. Cosimelli, 2005, Journal of medicinal chemistry.

A1 adenosine receptor antagonists, 3‐aryl[1,2,4]triazino[4,3‐a]benzimidazol‐4‐(10H)‐ones (ATBIs) and N‐alkyl and N‐acyl‐(7‐substituted‐2‐phenylimidazo[1,2‐a][1,3,5]triazin‐4‐yl)amines (ITAs): Different recognition of bovine and human binding sites

Ettore Novellino, Sabrina Taliani, Federico Da Settimo, 2004 .

Synthesis, structure-activity relationships, and molecular modeling studies of N-(indol-3-ylglyoxylyl)benzylamine derivatives acting at the benzodiazepine receptor.

E. Novellino, G. Greco, A. Da Settimo, 1996, Journal of medicinal chemistry.

Synthesis of pyrrolo[3,4-c]pyridine derivatives possessing an acid group and their in vitro and in vivo evaluation as aldose reductase inhibitors

G. Primofiore, A. Martinelli, C. L. Motta, 1996 .

Isosteric replacement of the indole nucleus by benzothiophene and benzofuran in a series of indolylglyoxylylamine derivatives with partial agonist activity at the benzodiazepine receptor

G. Primofiore, S. Taliani, C. Martini, 1996 .

Pharmacological characterization of a new Ca(2+) sensitizer.

G. Primofiore, F. Da Settimo, A. Marini, 2000, The Journal of pharmacology and experimental therapeutics.

3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists.

E Novellino, A Lavecchia, E. Novellino, 2001, Journal of medicinal chemistry.

3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: tricyclic heteroaromatic derivatives as a new class of benzodiazepine receptor ligands.

E. Novellino, G. Greco, G. Primofiore, 2000, Journal of medicinal chemistry.

5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.

E. Novellino, B. Cosimelli, G. Greco, 2007, Journal of medicinal chemistry.

N,N-dialkyl-2-phenylindol-3-ylglyoxylamides. A new class of potent and selective ligands at the peripheral benzodiazepine receptor.

E. Novellino, G. Greco, G. Primofiore, 2004, Journal of medicinal chemistry.

3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists.

E. Novellino, G. Greco, A. Lavecchia, 2001, Journal of medicinal chemistry.

Dialkylaminoalkylindolonaphthyridines as potential antitumour agents: synthesis, cytotoxicity and DNA binding properties.

A. Da Settimo, G. Primofiore, F. Da Settimo, 2002, European journal of medicinal chemistry.

Synthesis, in vitro antiproliferative activity and DNA-interaction of benzimidazoquinazoline derivatives as potential anti-tumor agents.

A. Da Settimo, G. Primofiore, F. Da Settimo, 2001, Farmaco.

Synthesis, DNA binding and in vitro antiproliferative activity of purinoquinazoline, pyridopyrimidopurine and pyridopyrimidobenzimidazole derivatives as potential antitumor agents

G. Primofiore, G. Viola, S. Salerno, 1998 .

Synthesis and antiproliferative evaluation of new aryl substituted pyrido[3′,2′:5,6]thiopyrano[4,3-c]pyrazoles

G. Primofiore, S. Salerno, A. Marini, 2005 .

Synthesis of New Heterocyclic Ring Systems via [1,3,5]Triazino[1,2-a]benzimidazole Derivatives†

G. Primofiore, A. Marini, C. L. Motta, 2005 .

Synthesis of Novel 1,4-Dihydropyrido[3',2':5,6]thiopyrano[4,3-c]pyrazoles and 5H-Pyrido[3',2':5,6]thiopyrano[4,3-d]pyrimidines as Potential Antiproliferative Agents

G. Primofiore, S. Salerno, A. Marini, 2003 .

Novel, highly potent aldose reductase inhibitors: cyano(2-oxo-2,3-dihydroindol-3-yl)acetic acid derivatives.

E. Novellino, G. Greco, A. Lavecchia, 2003, Journal of medicinal chemistry.

Synthesis of purinobenzodiazepine and purinobenzotriazocine derivatives, two new heterocyclic ring systems

G. Primofiore, S. Salerno, A. Marini, 1999 .

Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships.

E. Novellino, G. Greco, A. Lavecchia, 2001, Journal of medicinal chemistry.

Facile synthesis of 3-substituted [1,2,4]triazino[3,4-f]purine-4,6,8-trione derivatives

G. Primofiore, S. Salerno, A. Marini, 2001 .

Synthesis of a Novel Purine-Containing Heterocyclic Ring System: 8,10-Dimethylindolo[2',3':5,6][1,2,4]triazino[4,3-f]purine-9,11(8H,10H,13H)dione

G. Primofiore, S. Taliani, A. Marini, 2000 .

Synthesis, structure-activity relationships, and molecular modeling studies of N-(indol-3-ylglyoxylyl)benzylamine derivatives acting at the benzodiazepine receptor.

E. Novellino, G. Greco, A. Da Settimo, 1996, Journal of medicinal chemistry.

Indole amide derivatives : synthesis, structure-activity relationships and molecular modelling studies of a new series of histamine H1-receptor antagonists

Federico Da Settimo, G. Primofiore, A. Marini, 1999 .

Synthesis of novel 1-aryl[1]benzoxepino[5,4-c]pyrazole and [1]benzoxepino[5,4-d]pyrimidine derivatives

G. Primofiore, C. L. Motta, F. Settimo, 1993 .

N-(Indol-3-ylglyoxylyl)dopamine derivatives: preparation and anti-depressant activity

G. Primofiore, A. Marini, R. Cirillo, 1988 .

N-(Indol-3-ylglyoxylyl)methionine derivatives: preparation and gastric anti-secretory activity

G. Primofiore, A. Marini, A. D. Settimo, 1988 .

Refinement of the benzodiazepine receptor site topology by structure-activity relationships of new N-(heteroarylmethyl)indol-3-ylglyoxylamides.

E. Novellino, B. Cosimelli, Marina Ehlardo, 2006, Journal of medicinal chemistry.

Benzodiazepine receptor affinity and interaction of some N-(indol-3-ylglyoxylyl)amine derivatives.

A. Bianucci, A. Da Settimo, G. Primofiore, 1992, Journal of medicinal chemistry.

Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands.

E. Novellino, B. Cosimelli, G. Greco, 2007, Journal of medicinal chemistry.

N'-Phenylindol-3-ylglyoxylohydrazide derivatives: synthesis, structure-activity relationships, molecular modeling studies, and pharmacological action on brain benzodiazepine receptors.

E. Novellino, G. Greco, A. Da Settimo, 1998, Journal of medicinal chemistry.

Synthesis of 1,8-naphthyridine derivatives. Potential antihypertensive agents. II.

A. Da Settimo, G. Primofiore, A. Subissi, 1986, Il Farmaco; edizione scientifica.

Novel, highly potent adenosine deaminase inhibitors containing the pyrazolo[3,4-d]pyrimidine ring system. Synthesis, structure-activity relationships, and molecular modeling studies.

E. Novellino, A. Lavecchia, G. Primofiore, 2005, Journal of medicinal chemistry.

Reinvestigation of reductive butylation of aminophthalimides: new compounds with local anesthetic activity

G. Primofiore, A. D. Settimo, P. Ferrarini, 1989 .

1-substituted 2-benzylaminobenzimidazole derivatives: compounds with H1-antihistaminic activity

G. Primofiore, A. D. Settimo, O. Tofanetti, 1992 .

Synthesis of pyrimido[1,2-a]benzimidazol-4(10H)-one derivatives and evaluation of their interactions with DNA

G. Primofiore, S. Taliani, S. Salerno, 2003 .

An approach to novel fused triazole or tetrazole derivatives starting from Benzimidazo[1,2-a]quinazoline-5(7H)-one and 5,7-Dihydro-5-oxopyrido[3',2':5,6]pyrimido[1,2-a]benzimidazole

G. Primofiore, A. Marini, F. Simorini, 2002 .

Synthesis and β-blocking activity of (E)- and (Z)-iminoethers of 1,8-naphthyridine. Potential antihypertensive agents. 4

G. Primofiore, M. Breschi, P. Nieri, 1990 .

Synthesis of some 3,7-disubstituted quino[3,2-c][1,8]naphthyridines

G. Primofiore, A. Marini, O. Livi, 1980 .

.beta.-Adrenergic blocking agents of the chromone and xanthone groups. II. Propanolol type derivatives

G. Primofiore, A. Bertelli, P. Re, 1972 .

Synthesis and antiinflammatory properties of 2-aminobenzimidazole derivatives.

A. Da Settimo, G. Primofiore, F. Da Settimo, 1992, Farmaco.

Synthesis, antilipidemic and platelet antiaggregatory activity of 2-aminobenzimidazole amide derivatives.

G. Primofiore, F. Da Settimo, C. Cravanzola, 1989, Farmaco.

Synthesis of some 3‐substituted [1,8]naphthyrido[3,2‐c][1,8]naphthyridines. A new heterocyclic ring system

G. Primofiore, O. Livi, G. Biagi, 1981 .

Naphtho[1,2-d]isothiazole acetic acid derivatives as a novel class of selective aldose reductase inhibitors.

Ettore Novellino, Enrico Boldrini, Sabrina Taliani, 2005, Journal of medicinal chemistry.

Synthesis of some 5H,12H-[1]benzoxepino[4,3-b]indol-6-ones. A new heterocyclic ring system

G. Primofiore, F. Settimo, Fabio Chetoni, 1993 .

Spirohydantoin derivatives of thiopyrano[2,3-b]pyridin-4(4H)-one as potent in vitro and in vivo aldose reductase inhibitors.

E. Novellino, G. Greco, A. Lavecchia, 2005, Bioorganic & medicinal chemistry.

-Adrenergic blocking agents of the chromone and xanthone groups.

P. Valenti, G. Primofiore, P. Da re, 1972, Journal of medicinal chemistry.

Synthesis of novel pyrido[3′,2′:5,6]thiopyrano[3,2‐b]indol‐5(6H)‐ones and 6H‐pyrido[3′,2′:5,6]thiopyrano[4,3‐b]quinolines, two new heterocyclic ring systems

G. Primofiore, S. Salerno, A. Marini, 2002 .

[1,2,4]Triazino[4,3-a]benzimidazole acetic acid derivatives: a new class of selective aldose reductase inhibitors.

E. Novellino, G. Greco, A. Lavecchia, 2001, Journal of medicinal chemistry.

Synthesis and benzodiazepine receptor activity of some 4,5-dihydro-1H-pyrazolo[4,3-c][1,8]naphthyridine derivatives.

A. Da Settimo, G. Primofiore, F. Da Settimo, 1994, Drug design and discovery.

One step synthesis of pyrimido[1,2-a][1,8]naphthyridinones, pyrido[1,2-a]pyrimidinones and 1,8-naphthyridinones. Antihypertensive agents. V

G. Primofiore, C. Mori, P. Ferrarini, 1990 .

Synthesis of 2-methylaminobenzimidazole derivatives tested for antiinflammatory activity.

A. Da Settimo, G. Primofiore, F. Da Settimo, 1994, Farmaco.

Synthesis of novel 5H, 11H‐pyrido[2′,3′:2,3]thiopyrano[4,3‐b]‐indoles by fischer‐indole cyclization

G. Primofiore, S. Salerno, A. Marini, 2000 .

Specific inhibition of benzodiazepine receptor binding by some N-(indol-3-ylglyoxylyl)amino acid derivatives: stereoselective interactions.

G. Primofiore, F. Da Settimo, C. Martini, 1989, Journal of Medicinal Chemistry.

Indole derivatives as probes to study the benzodiazepine binding site in GABA receptor complex.

E. Novellino, G. Greco, A. Da Settimo, 1996, Advances in experimental medicine and biology.

One-step synthesis of 6H-indolo[2,3-b][1,8]naphthyridines. A new heterocyclic ring system

G. Primofiore, G. Biagi, A. D. Settimo, 1977 .

Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A(1) adenosine receptor antagonists.

E. Novellino, B. Cosimelli, G. Greco, 2002, Journal of medicinal chemistry.

Synthesis of purinobenzothiazine and pyridothiazinopurine derivatives. Two new heterocyclic ring systems

G. Primofiore, A. Marini, D. Bertini, 1998 .