H. Hsieh

发表

Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities.

I. Lu, Chien-Fu Huang, Yi-Hui Peng, 2006, Journal of medicinal chemistry.

Dual Kit/Aur Inhibitors as Chemosensitizing Agents for the Treatment of Melanoma: Design, Synthesis, Docking Studies and Functional Investigation

C. La Motta, H. Hsieh, Kai Liu, 2019, Scientific Reports.

Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: the role of the DFG motif in the design of epidermal growth factor receptor inhibitors.

P. Lyu, Yi-Hui Peng, H. Hsieh, 2013, Journal of medicinal chemistry.

Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification.

Santhosh Kumar Chittimalla, Yi-Hui Peng, H. Hsieh, 2010, Journal of medicinal chemistry.

Disruption of protein–protein interactions: hot spot detection, structure-based virtual screening and in vitro testing for the anti-cancer drug target – survivin

H. Hsieh, M. Coumar, Sailu Sarvagalla, 2016 .

Parallel Screening of Wild-Type and Drug-Resistant Targets for Anti-Resistance Neuraminidase Inhibitors

H. Hsieh, Jinn-Moon Yang, J. Horng, 2013, PloS one.

Antiviral drug discovery against SARS-CoV.

H. Hsieh, J. Hsu, Yu-Shan Wu, 2006, Current medicinal chemistry.

Design of drug-like hepsin inhibitors against prostate cancer and kidney stones

H. Hsieh, V. Blay, D. Houston, 2019, Acta pharmaceutica Sinica. B.

Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells.

H. Hsieh, J. Hsu, S. Chuang, 2007, Cancer letters.

Substituent effects on the photorearrangements of unsymmetrically substituted diazinobarrelenes

H. Hsieh, C. Liao, Ann-Cheng Chen, 2013 .

Synthesis and biological evaluation of 1-(4'-Indolyl and 6'-Quinolinyl) indoles as a new class of potent anticancer agents.

H. Hsieh, Su-Ying Wu, Jian-Sung Wu, 2011, European journal of medicinal chemistry.

2‐Amino‐3,4,5‐Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors

H. Hsieh, J. Liou, Jang-Yang Chang, 2011, ChemMedChem.

5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors.

H. Hsieh, Su-Ying Wu, Yuxiang Chen, 2010, Journal of medicinal chemistry.

Synthesis and Structure–Activity Relationships of 1‐Benzyl‐4,5,6‐trimethoxyindoles as a Novel Class of Potent Antimitotic Agents

H. Hsieh, T. Yeh, J. Liou, 2009, ChemMedChem.

Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents.

H. Hsieh, Su-Ying Wu, M. Coumar, 2008, Journal of medicinal chemistry.

Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents.

H. Hsieh, Shiow-Ju Lee, J. Liou, 2004, Journal of medicinal chemistry.

Comparative molecular field analysis of anti-tubulin agents with indole ring binding at the colchicine binding site

H. Hsieh, Irene Lin, Cheng-Chang Hsu, 2010 .

Identification of ligand efficient, fragment-like hits from an HTS library: structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity

Mohane Selvaraj Coumar, Yi-Yu Ke, Sailu Sarvagalla, 2014, Journal of Computer-Aided Molecular Design.

Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening.

H. Hsieh, M. Coumar, Shu-Yu Lin, 2019, Biochimie.

Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification

Yung Chang Hsu, H. Hsieh, J. Hsu, 2015, Scientific Reports.

A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors.

H. Hsieh, T. Lien, Y. Chao, 2008, Analytical biochemistry.

Aurora kinase inhibitor patents and agents in clinical testing: an update (2009 – 10)

H. Hsieh, M. Coumar, Jang-Yang Chang, 2011, Expert opinion on therapeutic patents.

Ligand efficiency based approach for efficient virtual screening of compound libraries.

H. Hsieh, J. Hsu, Szu-Huei Wu, 2014, European journal of medicinal chemistry.

Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors.

H. Hsieh, J. Hsu, M. Coumar, 2020, Bioorganic chemistry.

CDKN1A‐mediated responsiveness of MLL‐AF4‐positive acute lymphoblastic leukemia to Aurora kinase‐A inhibitors

H. Hsieh, W. Su, Liang-Yi Hung, 2014, International journal of cancer.

Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease.

Po-Huang Liang, I-Lin Lu, Chih-Jung Kuo, 2006, Journal of medicinal chemistry.

Delineating the active site architecture of G9a lysine methyltransferase through substrate and inhibitor binding mode analysis: a molecular dynamics study

H. Hsieh, M. Coumar, R. Sarma, 2018, Journal of biomolecular structure & dynamics.

Cancer Cells Acquire Mitotic Drug Resistance Properties Through Beta I-Tubulin Mutations and Alterations in the Expression of Beta-Tubulin Isotypes

H. Hsieh, Su-Ying Wu, Jian-Sung Wu, 2010, PloS one.

Colloidal Assemblies Composed of Polymeric Micellar/Emulsified Systems Integrate Cancer Therapy Combining a Tumor-Associated Antigen Vaccine and Chemotherapeutic Regimens

H. Hsieh, T. Hsu, Chiung-Yi Huang, 2021, Nanomaterials.

Chlorinated briarane diterpenoids from octocoral Briareum stechei (Kükenthal, 1908)

H. Hsieh, Z. Wen, P. Sung, 2021 .

Briarenols W–Z: Chlorine-Containing Polyoxygenated Briaranes from Octocoral Briareum stechei (Kükenthal, 1908)

H. Hsieh, Z. Wen, P. Sung, 2021, Marine drugs.

A high-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors.

H. Hsieh, T. Lien, Y. Chao, 2012, Anticancer research.

Aurintricarboxylic acid inhibits influenza virus neuraminidase

H. Hsieh, Y. Chao, Jinn-Moon Yang, 2008, Antiviral Research.

Evaluation of metal‐conjugated compounds as inhibitors of 3CL protease of SARS‐CoV

H. Hsieh, Xin Chen, J. Hsu, 2004, FEBS Letters.

Identification of Two Novel Small Compounds that Inhibit Liver Cancer Formation in Zebrafish and Analysis of Their Conjugation to Nanodiamonds to Further Reduce Toxicity

C. Yuh, H. Hsieh, Chia‐Liang Cheng, 2019, Advanced Therapeutics.

Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer

H. Hsieh, H. Kung, Jai-Shin Liu, 2022, Journal of biomedical science.

An Antimitotic and Antivascular Agent BPR0L075 Overcomes Multidrug Resistance and Induces Mitotic Catastrophe in Paclitaxel-Resistant Ovarian Cancer Cells

H. Hsieh, Tian-Li Wang, E. Wu, 2013, PloS one.

Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors.

H. Hsieh, C. Chen, Xin Chen, 2006, Bioorganic & medicinal chemistry letters.

Microwave Induced Synthesis of 3,4‐Dihydro‐2H‐pyran‐2‐carboxaldehyde: A Versatile Linker for Solid Phase Combinatorial Library

H. Hsieh, Shui-Tein Chen, Kung-Tsung Wang, 1997 .

A novel bis-benzylidenecyclopentanone derivative, BPR0Y007, inducing a rapid caspase activation involving upregulation of Fas (CD95/APO-1) and wild-type p53 in human oral epidermoid carcinoma cells.

H. Hsieh, J. Liou, Jang-Yang Chang, 2004, Biochemical pharmacology.

Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors.

H. Hsieh, Jen‐Shin Song, Yu-Wei Liu, 2015, Journal of medicinal chemistry.

A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodies

H. Hsieh, M. Tao, F. Hsu, 2022, Journal of biomedical science.

BPR1K653, a Novel Aurora Kinase Inhibitor, Exhibits Potent Anti-Proliferative Activity in MDR1 (P-gp170)-Mediated Multidrug-Resistant Cancer Cells

H. Hsieh, T. Lien, J. Hsu, 2011, PloS one.

Direct Solid Phase Synthesis of Biologically Active Peptide Alcohols

H. Hsieh, Shui-Tein Chen, Kung-Tsung Wang, 1999 .

Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition.

H. Hsieh, Jen‐Shin Song, C. Shih, 2018, European journal of medicinal chemistry.

Aurora kinase A inhibitors: identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold.

H. Hsieh, Y. Chao, J. Hsu, 2008, Bioorganic & medicinal chemistry letters.

Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers

H. Hsieh, M. Coumar, Huang-Hui Chen, 2009, Molecular Cancer.

Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents.

H. Hsieh, Jen‐Shin Song, Chung-Ming Chang, 2002, Journal of medicinal chemistry.

Biotransformation of 6-Methoxy-3-(3′,4′,5′-trimethoxy-benzoyl)-1H-indole (BPR0L075), a Novel Antimicrotubule Agent, by Mouse, Rat, Dog, and Human Liver Microsomes

H. Hsieh, C. Chen, Y. Chao, 2007, Drug Metabolism and Disposition.

Strategies of development of antiviral agents directed against influenza virus replication.

H. Hsieh, J. Hsu, 2007, Current pharmaceutical design.

Scaffold-hopping strategy: synthesis and biological evaluation of 5,6-fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents.

H. Hsieh, C. Liao, Su-Ying Wu, 2011, Journal of medicinal chemistry.

Syntheses of Two Pyridine C-Nucleosides as "Deletion-Modified" Analogs of dT and dC

H. Hsieh, L. McLaughlin, 1995 .

Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system.

H. Hsieh, T. Lien, J. Hsu, 2006, Bioorganic & medicinal chemistry.

Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents.

H. Hsieh, N. Mahindroo, J. Liou, 2004, Journal of medicinal chemistry.

Pharmaceutical design of antimitotic agents based on combretastatins.

H. Hsieh, N. Mahindroo, J. Liou, 2005, Current pharmaceutical design.

Structural Basis for the Improved Potency of Peroxisome Proliferator‐Activated Receptor (PPAR) Agonists

Ping-Chiang Lyu, Mohane Selvaraj Coumar, Chien-Fu Huang, 2010, ChemMedChem.

Reactions of 2-hydroxybenzophenones with Corey–Chaykovsky reagent

Santhosh Kumar Chittimalla, H. Hsieh, C. Liao, 2008 .

Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach.

H. Hsieh, C. Chen, Su-Ying Wu, 2009, Journal of medicinal chemistry.

Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives.

H. Hsieh, C. Liao, Y. Chao, 2010, Journal of medicinal chemistry.

Synthesis and biological evaluation of 1-methyl-2-(3',4',5'-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors.

H. Hsieh, A. Brancale, O. Cruz-López, 2008, Journal of medicinal chemistry.

Researchcompound BPR1P0034 with potent and selective anti-influenza virus activity

H. Hsieh, Y. Chao, Hsiu-Ling Chen, 2010 .

Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity

H. Hsieh, Y. Chao, Hsiu-Ling Chen, 2010, Journal of Biomedical Science.

Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity.

Ping-Chiang Lyu, Mohane Selvaraj Coumar, Yu-Sheng Chao, 2009, Journal of medicinal chemistry.

4- and 5-aroylindoles as novel classes of potent antitubulin agents.

H. Hsieh, J. Liou, Jang-Yang Chang, 2007, Journal of medicinal chemistry.

Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and Michael acceptor group for maximal potency.

Sing-Yi Wang, Mohane Selvaraj Coumar, Yu-Sheng Chao, 2010, Journal of medicinal chemistry.

Antitubulin agents for the treatment of cancer – a medicinal chemistry update

H. Hsieh, N. Mahindroo, J. Liou, 2006 .

Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies.

Thy-Hou Lin, Po-Huang Liang, I-Lin Lu, 2006, Journal of medicinal chemistry.

Structure–Activity Relationship Studies of 3‐Aroylindoles as Potent Antimitotic Agents

Yi-Wei Chang, Hsing-Pang Hsieh, Uan-Kang Tan, 2006, ChemMedChem.

Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors.

H. Hsieh, J. Liou, Jang-Yang Chang, 2008, Journal of medicinal chemistry.

Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis.

P. Lyu, H. Hsieh, M. D. Chang, 2010, Journal of medicinal chemistry.

Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine Aurora kinase inhibitor.

H. Hsieh, C. Chen, Y. Chao, 2013, Journal of medicinal chemistry.

Dihydropyran-2-carboxylic acid, a novel bifunctional linker for the solid-phase synthesis of peptides containing a C-terminal alcohol

H. Hsieh, Shui-Tein Chen, Yinghan Wu, 1998 .

FACILE SOLID PHASE SYNTHESIS OF OCTREOTIDE ANALOGS USING P-CARBOXYBENZALDEHYDE AS A NOVEL LINKER TO ANCHOR FMOC-THREONINOL TO SOLID PHASE RESINS

H. Hsieh, Shui-Tein Chen, Hui‐Ming Yu, 1998 .

Development of a Robust Scale-Up Synthetic Route for BPR1K871: A Clinical Candidate for the Treatment of Acute Myeloid Leukemia and Solid Tumors

H. Hsieh, M. Coumar, Hsu-Yi Sun, 2021 .

Biomimetic Syntheses of (±)-Isopalhinine A, (±)-Palhinine A, and (±)-Palhinine D.

H. Hsieh, Hui-Yi Shiao, B. Uang, 2018, Angewandte Chemie.

Direct solid-phase synthesis of octreotide conjugates: precursors for use as tumor-targeted radiopharmaceuticals.

H. Hsieh, K. T. Wang, S. T. Chen, 1999, Bioorganic & medicinal chemistry.

Structural effects in novel steroidal polyamine-DNA binding

H. Hsieh, C. Burrows, J. Muller, 1994 .

Synthesis and DNA binding properties of C3-, C12-, and C24-substituted amino-steroids derived from bile acids.

H. Hsieh, C. Burrows, J. Muller, 1995, Bioorganic & medicinal chemistry.

Design of a potent anticancer lead inspired by natural products from traditional Indian medicine

H. Hsieh, M. Coumar, Shu-Yu Lin, 2020, Journal of biomolecular structure & dynamics.

Anti-HSV activity of digitoxin and its possible mechanisms.

H. Hsieh, J. Hsu, Chun-Nan Lee, 2008, Antiviral research.

Bioassay‐guided purification and identification of PPARα/γ agonists from Chlorella sorokiniana

Chien-Fu Huang, H. Hsieh, T. Lien, 2008, Phytotherapy research : PTR.

Inhibition of Severe Acute Respiratory Syndrome Coronavirus Replication by Niclosamide

H. Hsieh, Y. Chao, J. Hsu, 2004, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics of Anti-SARS-CoV Agent Niclosamide and Its Analogs in Rats

H. Hsieh, C. Chen, T. Yeh, 2006 .

Discovery of BPR1R024, an Orally Active and Selective CSF1R Inhibitor that Exhibits Antitumor and Immunomodulatory Activity in a Murine Colon Tumor Model.

H. Hsieh, C. Chen, C. Shih, 2021, Journal of medicinal chemistry.

Drug repurposing for chronic myeloid leukemia: in silico and in vitro investigation of DrugBank database for allosteric Bcr-Abl inhibitors

H. Hsieh, M. Coumar, V. Singh, 2017, Journal of biomolecular structure & dynamics.

Structure-activity and crystallographic analysis of benzophenone derivatives-the potential anticancer agents.

Chi-Hung Lin, Ying-Ting Lin, H. Hsieh, 2003, Bioorganic & medicinal chemistry letters.

First total syntheses of (+/-)-annuionone B and (+/-)-tanarifuranonol.

H. Hsieh, C. Liao, Hui-Yi Shiao, 2008, Organic Letters.

7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents.

H. Hsieh, J. Liou, Jang-Yang Chang, 2006, Journal of medicinal chemistry.

BPR-3P0128 inhibits RNA-dependent RNA polymerase elongation and VPg uridylylation activities of Enterovirus 71.

H. Hsieh, J. Hsu, J. Horng, 2014, Antiviral research.

Structure—Activity and Crystallographic Analysis of Benzophenone Derivatives — The Potential Anticancer Agents.

H. Hsieh, 2003 .

BPR0L075, a Novel Synthetic Indole Compound with Antimitotic Activity in Human Cancer Cells, Exerts Effective Antitumoral Activity in Vivo

H. Hsieh, C. Chen, Shiow-Ju Lee, 2004, Cancer Research.

Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: application to a pharmacokinetic study.

H. Hsieh, C. Chen, Y. Chao, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Biomimetic Syntheses of (±)‐Isopalhinine A, (±)‐Palhinine A, and (±)‐Palhinine D

H. Hsieh, Hui-Yi Shiao, B. Uang, 2018, Angewandte Chemie.

First Total Syntheses of (.+-.)-Annuionone B (I) and (.+-.)-Tanarifuranonol (IIa).

H. Hsieh, C. Liao, Hui-Yi Shiao, 2008 .

Dual inhibition of topoisomerase I and tubulin polymerization by BPR0Y007, a novel cytotoxic agent.

H. Hsieh, Jen‐Shin Song, J. Liou, 2003, Biochemical pharmacology.

A selective Aurora-A 5'-UTR siRNA inhibits tumor growth and metastasis.

H. Hsieh, C. Yen, S. Tsai, 2019, Cancer letters.

A Novel Aurora-A Inhibitor, BPR1K0609S1, Sensitizes Colorectal Tumor cells to 5-Fluorofracil (5-FU) Treatment

T. Ouchi, H. Hsieh, J. Hsu, 2013, International Journal of Biological Sciences.

A Novel Aurora-A Inhibitor, BPR1K0609S1, Sensitizes Colorectal Tumor cells to 5-Fluorofracil (5-FU) Treatment

T. Ouchi, H. Hsieh, J. Hsu, 2013, International journal of biological sciences.

A novel peroxisome proliferator-activated receptor &agr;/&ggr; agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells

H. Hsieh, S. Chuang, Jang-Yang Chang, 2008, Anti-cancer drugs.

Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

Chi-Ying F. Huang, Yi-Hui Peng, H. Hsieh, 2013, Proceedings of the National Academy of Sciences.

Aurora kinase inhibitors in preclinical and clinical testing.

H. Hsieh, M. Coumar, Jang-Yang Chang, 2009, Expert opinion on investigational drugs.

Aurora kinase inhibitors in preclinical and clinical testing

Mohane Selvaraj Coumar, Jang-Yang Chang, H. Hsieh, 2009, Expert opinion on investigational drugs.

Pronounced induction of endoplasmic reticulum stress and tumor suppression by surfactant-free poly(lactic-co-glycolic acid) nanoparticles via modulation of the PI3K signaling pathway

H. Hsieh, D. Shieh, C. Yeh, 2013, International journal of nanomedicine.

Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design.

Wen-Chieh Wang, Wen-Hsing Lin, Hsing-Pang Hsieh, 2016, European journal of medicinal chemistry.

Facile Identification of Dual FLT3–Aurora A Inhibitors: A Computer‐Guided Drug Design Approach

H. Hsieh, J. Hsu, Yi-Yu Ke, 2014, ChemMedChem.

Insights for the design of protein lysine methyltransferase G9a inhibitors.

H. Hsieh, M. Coumar, Arunkumar Dhayalan, 2019, Future medicinal chemistry.

Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer.

Yi-Hui Peng, H. Hsieh, C. Chen, 2019, Journal of medicinal chemistry.

Anaplastic Lymphoma Kinase (ALK) Inhibitors: New Cancer Breakthroughs for Lung Cancer

H. Hsieh, Hui-Yi Shiao, N. Chiang, 2011 .

Anaplastic lymphoma kinase (ALK) inhibitors: a review of design and discovery

H. Hsieh, Hui-Yi Shiao, Wen-Chieh Wang, 2014 .

Identification, SAR Studies, and X‐ray Co‐crystallographic Analysis of a Novel Furanopyrimidine Aurora Kinase A Inhibitor

H. Hsieh, Y. Chao, J. Hsu, 2010, ChemMedChem.

Inhibition of HIV-1 Tat-Mediated Transcription by a Coumarin Derivative, BPRHIV001, through the Akt Pathway

H. Hsieh, Y. Chao, Sui‐Yuan Chang, 2011, Journal of Virology.

Small-molecule EGFR tyrosine kinase inhibitors for the treatment of cancer

H. Hsieh, Hui-Yi Shiao, Wen-Chieh Wang, 2014, Expert opinion on investigational drugs.

BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses.

H. Hsieh, Y. Chao, L. Poon, 2010, The Journal of antimicrobial chemotherapy.

Novel FLT3/AURK multikinase inhibitor is efficacious against sorafenib-refractory and sorafenib-resistant hepatocellular carcinoma

H. Hsieh, W. Yen, You-Liang Lai, 2022, Journal of biomedical science.

Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus

Hsing-Pang Hsieh, H. Hsieh, Xin Chen, 2008, Biochemical Pharmacology.

Antiangiogenic activities and cisplatin-combined antitumor activities of BPR0L075.

H. Hsieh, C. Chen, Y. Chao, 2010, Anticancer research.

Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca2+ entry.

H. Hsieh, W. Chang, Jang-Yang Chang, 2019, Biochimica et biophysica acta. Molecular cell research.

Bortezomib Overcomes Tumor Necrosis Factor-related Apoptosis-inducing Ligand Resistance in Hepatocellular Carcinoma Cells in Part through the Inhibition of the Phosphatidylinositol 3-Kinase/Akt Pathway*

H. Hsieh, Kuen-Feng Chen, Chiun Hsu, 2009, Journal of Biological Chemistry.

Identification of BPR3P0128 as an Inhibitor of Cap-Snatching Activities of Influenza Virus

H. Hsieh, J. Hsu, Ta-Jen Lin, 2011, Antimicrobial Agents and Chemotherapy.

Tubulin-Destabilizing Agent BPR0L075 Induces Vascular-Disruption in Human Breast Cancer Mammary Fat Pad Xenografts

H. Hsieh, R. Mason, Xinli Liu, 2012, PloS one.

Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer

H. Hsieh, M. Coumar, T. Yeh, 2017, Scientific Reports.

Development of Furanopyrimidine-Based Orally Active Third-Generation EGFR Inhibitors for the Treatment of Non-Small Cell Lung Cancer

H. Hsieh, C. Chen, T. Lien, 2023, Journal of medicinal chemistry.

Identification of Entry Inhibitors against Delta and Omicron Variants of SARS-CoV-2

H. Juan, H. Hsieh, Sui‐Yuan Chang, 2022, International journal of molecular sciences.

Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies.

Ping-Chiang Lyu, I-Lin Lu, Ying-Ting Lin, 2006, Journal of medicinal chemistry.

Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3′-digallate (TF3)

Po-Huang Liang, Coney P. C. Lin, H. Hsieh, 2005, Evidence-based complementary and alternative medicine : eCAM.

One-Pot Synthesis of Dibenzo[b,f]oxepines and Total Synthesis of Bauhinoxepin C.

H. Hsieh, B. Uang, P. Ngernmeesri, 2021, Journal of Organic Chemistry.

Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities.

I-Lin Lu, Chien-Fu Huang, Yu-Sheng Chao, 2005, Journal of medicinal chemistry.

Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity.

Mohane Selvaraj Coumar, Yu-Sheng Chao, Su-Ying Wu, 2009, Journal of medicinal chemistry.

Overcoming vincristine resistance in cancer: Computational design and discovery of piperine‐inspired P‐glycoprotein inhibitors

H. Hsieh, M. Coumar, T. Yeh, 2020, Chemical biology & drug design.

Advances in Aurora kinase inhibitor patents

H. Hsieh, M. Coumar, Jang-Yang Chang, 2009, Expert opinion on therapeutic patents.

Mimicking H3 Substrate Arginine in the Design of G9a Lysine Methyltransferase Inhibitors for Cancer Therapy: A Computational Study for Structure-Based Drug Design

H. Hsieh, M. Coumar, Mu-Chun Li, 2021, ACS omega.

3-[2-((2S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes.

H. Hsieh, C. Chen, Xin Chen, 2007, Bioorganic & medicinal chemistry letters.

3D‐QSAR‐Assisted Drug Design: Identification of a Potent Quinazoline‐Based Aurora Kinase Inhibitor

Yung Chang Hsu, H. Hsieh, Y. Chao, 2013, ChemMedChem.

Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists.

Ping-Chiang Lyu, I-Lin Lu, Yu-Sheng Chao, 2007, Journal of medicinal chemistry.

Tumor‐agnostic inhibitors in oncology: A new phase for precision medicine

H. Hsieh, Mu-Chun Li, 2020 .

Anaplastic Lymphoma Kinase (ALK) Inhibitors: New Cancer Breakthroughs for Lung Cancer

H. Hsieh, Hui-Yi Shiao, N. Chiang, 2011 .

Erratum: Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents (Bioorganic and Medicinal Chemistry Letters (2003) 13 (101) PII S0960894X02008508)

Chi-Hung Lin, Ying-Ting Lin, H. Hsieh, 2003 .

Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer

H. Hsieh, M. Coumar, T. Yeh, 2017, Scientific Reports.

BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses.

H. Hsieh, Y. Chao, L. Poon, 2010, The Journal of antimicrobial chemotherapy.

Therapeutic polymeric nanoparticles and the methods of making and using thereof: a patent evaluation of WO2015036792

H. Hsieh, M. Coumar, Sailu Sarvagalla, 2016, Expert opinion on therapeutic patents.

Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

Chi-Ying F. Huang, Yi-Hui Peng, H. Hsieh, 2013, Proceedings of the National Academy of Sciences.

Advances in Aurora kinase inhibitor patents

H. Hsieh, M. Coumar, Jang-Yang Chang, 2009, Expert opinion on therapeutic patents.

2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.

I. Lu, H. Hsieh, C. Chen, 2006, Journal of medicinal chemistry.

Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists.

Mohane Selvaraj Coumar, Yu-Sheng Chao, Su-Ying Wu, 2009, Journal of medicinal chemistry.