T. Lien

发表

Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities.

I. Lu, Chien-Fu Huang, Yi-Hui Peng, 2006, Journal of medicinal chemistry.

Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification.

Santhosh Kumar Chittimalla, Yi-Hui Peng, H. Hsieh, 2010, Journal of medicinal chemistry.

A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors.

H. Hsieh, T. Lien, Y. Chao, 2008, Analytical biochemistry.

A high-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors.

H. Hsieh, T. Lien, Y. Chao, 2012, Anticancer research.

BPR1K653, a Novel Aurora Kinase Inhibitor, Exhibits Potent Anti-Proliferative Activity in MDR1 (P-gp170)-Mediated Multidrug-Resistant Cancer Cells

H. Hsieh, T. Lien, J. Hsu, 2011, PloS one.

Notice of RetractionDisulfiram is a Novel Modulator for PPAR

Chien-Fu Huang, T. Lien, J. Hsu, 2011, 2011 5th International Conference on Bioinformatics and Biomedical Engineering.

Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system.

H. Hsieh, T. Lien, J. Hsu, 2006, Bioorganic & medicinal chemistry.

Structural Basis for the Improved Potency of Peroxisome Proliferator‐Activated Receptor (PPAR) Agonists

Ping-Chiang Lyu, Mohane Selvaraj Coumar, Chien-Fu Huang, 2010, ChemMedChem.

Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and Michael acceptor group for maximal potency.

Sing-Yi Wang, Mohane Selvaraj Coumar, Yu-Sheng Chao, 2010, Journal of medicinal chemistry.

Haemolymph parameters of Pacific white shrimp (Litopenaeus vannamei) infected with Taura syndrome virus.

T. Lien, Yen-ling Song, Chun I Yu, 2003, Fish & shellfish immunology.

Bioassay‐guided purification and identification of PPARα/γ agonists from Chlorella sorokiniana

Chien-Fu Huang, H. Hsieh, T. Lien, 2008, Phytotherapy research : PTR.

Inhibition of Hepatitis C Virus Replication by Antimonial Compounds

T. Lien, J. Hsu, C. Yeh, 2005, Antimicrobial Agents and Chemotherapy.

High-throughput cell-based screening for hepatitis C virus NS3/4A protease inhibitors.

T. Lien, J. Hsu, Jin-Ching Lee, 2005, Assay and drug development technologies.

Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer.

Yi-Hui Peng, H. Hsieh, C. Chen, 2019, Journal of medicinal chemistry.

Suppression of Stat3 activity sensitizes gefitinib-resistant non small cell lung cancer cells.

T. Lien, D. Chou, Wen-Hsing Lin, 2011, Biochemical pharmacology.

Development of Furanopyrimidine-Based Orally Active Third-Generation EGFR Inhibitors for the Treatment of Non-Small Cell Lung Cancer

H. Hsieh, C. Chen, T. Lien, 2023, Journal of medicinal chemistry.

Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies.

Ping-Chiang Lyu, I-Lin Lu, Ying-Ting Lin, 2006, Journal of medicinal chemistry.

Genomic Similarity of Taura Syndrome Virus (TSV) between Taiwan and Western Hemisphere Isolates

T. Lien, Yen-ling Song, Chih-Cheng Huang, 2002 .

Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents

Chi-Hung Lin, C. Chen, T. Lien, 2012, Investigational new drugs.

Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities.

I-Lin Lu, Chien-Fu Huang, Yu-Sheng Chao, 2005, Journal of medicinal chemistry.

Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity.

Mohane Selvaraj Coumar, Yu-Sheng Chao, Su-Ying Wu, 2009, Journal of medicinal chemistry.

Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists.

Ping-Chiang Lyu, I-Lin Lu, Yu-Sheng Chao, 2007, Journal of medicinal chemistry.

Suppression of Stat3 activity sensitizes gefitinib-resistant non small cell lung cancer cells.

T. Lien, D. Chou, Wen-Hsing Lin, 2011, Biochemical pharmacology.

Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists.

Mohane Selvaraj Coumar, Yu-Sheng Chao, Su-Ying Wu, 2009, Journal of medicinal chemistry.