Xin Chen

发表

Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities.

I. Lu, Chien-Fu Huang, Yi-Hui Peng, 2006, Journal of medicinal chemistry.

Biochemical properties of recombinant prolyl dipeptidases DPP-IV and DPP8.

Xin Chen, 2006, Advances in experimental medicine and biology.

A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors.

I. Lu, N. Mahindroo, Xin Chen, 2008, European journal of medicinal chemistry.

EDEM2 and OS-9 Are Required for ER-Associated Degradation of Non-Glycosylated Sonic Hedgehog

Xin Chen, J. Christianson, Chih-Hsiang Huang, 2014, PloS one.

Thiopurine Analogue Inhibitors of Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease, a Deubiquitinating and deISGylating Enzyme

Xin Chen, G. Chang, C. Chou, 2009, Antiviral chemistry & chemotherapy.

Evaluation of metal‐conjugated compounds as inhibitors of 3CL protease of SARS‐CoV

H. Hsieh, Xin Chen, J. Hsu, 2004, FEBS Letters.

Cleavage-site specificity of prolyl endopeptidase FAP investigated with a full-length protein substrate.

Xin Chen, M. Hwang, Chih-Hsiang Huang, 2011, Journal of biochemistry.

1 INVESTIGATION OF THE DIMER INTERFACE AND SUBSTRATE SPECIFICITY OF PROLYL DIPEPTIDASE DPP 8

Xin Chen, Chun-Hung Lin, G. Chang, 2006 .

Investigation of the Dimer Interface and Substrate Specificity of Prolyl Dipeptidase DPP8*

Xin Chen, Chun-Hung Lin, G. Chang, 2006, Journal of Biological Chemistry.

Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors.

H. Hsieh, C. Chen, Xin Chen, 2006, Bioorganic & medicinal chemistry letters.

Role of a propeller loop in the quaternary structure and enzymatic activity of prolyl dipeptidases DPP‐IV and DPP9

Xin Chen, Hsiang-Yun Tang, C. Chou, 2011, FEBS letters.

(1,3-Diphenyl-1H-pyrazol-4-yl)-methylamine Analogues as Inhibitors of Dipeptidyl Peptidases

C. Chen, Xin Chen, Y. Chao, 2009 .

Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors.

C. Chen, Xin Chen, Y. Chao, 2009, Bioorganic & medicinal chemistry.

Glutamic acid analogues as potent dipeptidyl peptidase IV and 8 inhibitors.

I. Lu, Xin Chen, Su-Ying Wu, 2005, Bioorganic & medicinal chemistry letters.

Purification and characterization of human prolyl dipeptidase DPP8 in Sf9 insect cells.

C. Goparaju, Xin Chen, J. Hsu, 2004, Protein expression and purification.

Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal?

Xin Chen, A. Lambeir, I. De Meester, 2011, Journal of medicinal chemistry.

Inhibition of dipeptidyl-peptidase IV catalyzed peptide truncation by Vildagliptin ((2S)-{[(3-hydroxyadamantan-1-yl)amino]acetyl}-pyrrolidine-2-carbonitrile).

Xin Chen, A. Lambeir, I. De Meester, 2005, Biochemical pharmacology.

Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: isoindoline containing inhibitors.

Xin Chen, A. Lambeir, I. De Meester, 2008, Bioorganic & medicinal chemistry letters.

Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: identification of dipeptide derived leads.

Xin Chen, A. Lambeir, I. De Meester, 2008, Bioorganic & medicinal chemistry letters.

Dipeptidyl peptidase 8/9‐like activity in human leukocytes

Xin Chen, A. Lambeir, I. De Meester, 2007, Journal of leukocyte biology.

Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor.

Xin Chen, Y. Chao, Chih-Hsiang Huang, 2009, Biochemical pharmacology.

(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.

C. Chen, Xin Chen, Y. Chao, 2010, Bioorganic & medicinal chemistry letters.

Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors.

C. Chen, Xin Chen, Y. Chao, 2009, Bioorganic & medicinal chemistry letters.

Structural Basis for the Improved Potency of Peroxisome Proliferator‐Activated Receptor (PPAR) Agonists

Ping-Chiang Lyu, Mohane Selvaraj Coumar, Chien-Fu Huang, 2010, ChemMedChem.

Enzyme Activity and Immunohistochemical Localization of Dipeptidyl Peptidase 8 and 9 in Male Reproductive Tissues

Xin Chen, A. Lambeir, V. Dubois, 2009, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8.

Xin Chen, Shiow-Ju Lee, T. Hsu, 2005, Bioorganic & medicinal chemistry letters.

Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates.

Xin Chen, A. Lambeir, I. De Meester, 2007, Journal of medicinal chemistry.

Bioassay‐guided purification and identification of PPARα/γ agonists from Chlorella sorokiniana

Chien-Fu Huang, H. Hsieh, T. Lien, 2008, Phytotherapy research : PTR.

Papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV): expression, purification, characterization, and inhibition.

Xin Chen, J. Hsu, S. Yeh, 2005, Biochemistry.

One Site Mutation Disrupts Dimer Formation in Human DPP-IV Proteins*

Xin Chen, G. Chang, P. Liang, 2004, Journal of Biological Chemistry.

Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus

Hsing-Pang Hsieh, H. Hsieh, Xin Chen, 2008, Biochemical Pharmacology.

Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein.

Xin Chen, Y. Chao, Jen‐Shin Song, 2010, Journal of medicinal chemistry.

Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies.

Ping-Chiang Lyu, I-Lin Lu, Ying-Ting Lin, 2006, Journal of medicinal chemistry.

Identification of hydrophobic residues critical for DPP-IV dimerization.

Chun-Hung Lin, Chia-Hua Tsai, Xin Chen, 2006, Biochemistry.

The dimeric transmembrane domain of prolyl dipeptidase DPP‐IV contributes to its quaternary structure and enzymatic activities

Xin Chen, M. Hwang, W. Jiaang, 2010, Protein science : a publication of the Protein Society.

Downregulation of Signaling-active IGF-1 by Dipeptidyl Peptidase IV (DPP-IV)

Xin Chen, J. Shyy, Hsiang-Yun Tang, 2010, International journal of biomedical science : IJBS.

Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities.

I-Lin Lu, Chien-Fu Huang, Yu-Sheng Chao, 2005, Journal of medicinal chemistry.

3-[2-((2S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes.

H. Hsieh, C. Chen, Xin Chen, 2007, Bioorganic & medicinal chemistry letters.

Purification and characterization of a dipeptidyl peptidase 9-like enzyme from bovine testes

Xin Chen, A. Lambeir, J. Creemers, 2007 .

Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists.

Ping-Chiang Lyu, I-Lin Lu, Yu-Sheng Chao, 2007, Journal of medicinal chemistry.

Probing for improved selectivity with dipeptide-derived inhibitors of dipeptidyl peptidases 8 and 9: the impact of P1-variation

Xin Chen, A. Lambeir, J. Joossens, 2016 .

Purification and characterization of dipeptidyl peptidase IV-like enzymes from bovine testes.

Xin Chen, A. Lambeir, I. De Meester, 2008, Frontiers in Bioscience.

2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.

I. Lu, H. Hsieh, C. Chen, 2006, Journal of medicinal chemistry.

Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists.

Mohane Selvaraj Coumar, Yu-Sheng Chao, Su-Ying Wu, 2009, Journal of medicinal chemistry.