Y. Chao

Y. Chao, Chieh-Jui Hsieh, Szu-Huei Wu, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Synthesis, activity, and pharmacokinetic properties of a series of conformationally-restricted thiourea analogs as novel hepatitis C virus inhibitors.

A. Yueh, Y. Chao, T. Yeh, 2010, Bioorganic & medicinal chemistry.

Design and synthesis of indole, 2,3-dihydro-indole, and 3,4-dihydro-2H-quinoline-1-carbothioic acid amide derivatives as novel HCV inhibitors.

A. Yueh, Y. Chao, T. Hsu, 2009, Bioorganic & medicinal chemistry letters.

Design and efficient synthesis of novel arylthiourea derivatives as potent hepatitis C virus inhibitors.

A. Yueh, Y. Chao, T. Hsu, 2009, Bioorganic & medicinal chemistry letters.

Novel Small-Molecule Inhibitors of Transmissible Gastroenteritis Virus

Y. Chao, Hwan-You Chang, Shiow-Ju Lee, 2007, Antimicrobial Agents and Chemotherapy.

A high-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors.

H. Hsieh, T. Lien, Y. Chao, 2012, Anticancer research.

SynthesisandBiologicalActivitiesof2-Amino-1-arylidenaminoImidazolesasOrallyActiveAnticancer Agents

Chi-Hung Lin, C. Chen, Y. Chao, 2010 .

Synthesis and biological activities of 2-amino-1-arylidenamino imidazoles as orally active anticancer agents.

Chi-Hung Lin, C. Chen, Y. Chao, 2010, Journal of medicinal chemistry.

Aurintricarboxylic acid inhibits influenza virus neuraminidase

H. Hsieh, Y. Chao, Jinn-Moon Yang, 2008, Antiviral Research.

Nascent high density lipoproteins from liver perfusates of orotic acid-fed rats.

Y. Chao, R. Havel, R. Hamilton, 1986, Journal of lipid research.

A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus.

C. Chen, A. Yueh, Y. Chao, 2019, European journal of medicinal chemistry.

A Potent, Selective, and Orally Bioavailable HCV NS5A Inhibitor for Treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazol-2-yl)pyrrolidine-2-carboxamide.

A. Yueh, Y. Chao, Jen‐Shin Song, 2017, Journal of medicinal chemistry.

BPR0C261 is a novel orally active antitumor agent with antimitotic and anti‐angiogenic activities

Chi-Hung Lin, C. Chen, Y. Chao, 2011, Cancer science.

Pharmacological Induction of Human Fetal Globin Gene in Hydroxyurea-Resistant Primary Adult Erythroid Cells

Y. Chao, Jen‐Shin Song, Y. Chou, 2015, Molecular and Cellular Biology.

The estradiol-stimulated lipoprotein receptor of rat liver. A binding site that membrane mediates the uptake of rat lipoproteins containing apoproteins B and E.

Y. Chao, R. Havel, M. Brown, 1980, The Journal of biological chemistry.

Isoprotein specificity in the hepatic uptake of apolipoprotein E and the pathogenesis of familial dysbetalipoproteinemia.

Y. Chao, R. Havel, E. Windler, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors.

H. Hsieh, C. Chen, Xin Chen, 2006, Bioorganic & medicinal chemistry letters.

Binding of nuclear proteins to the enhancer elements of the rat apolipoprotein A-I gene.

Y. Chao, P. Dai, S. S. Lan, 1990, European journal of biochemistry.

Rabbit apolipoprotein A-I mRNA and gene. Evidence that rabbit apolipoprotein A-I is synthesized in the intestine but not in the liver.

Y. Chao, T. Yamin, P. Kroon, 1987, European journal of biochemistry.

Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells

Y. Chao, Jinq-chyi Lee, Shiow-Ju Lee, 2014, Oncotarget.

DECREASED SERUM CHOLESTEROL-BINDING RESERVE IN PREMATURE MYOCARDIAL INFARCTION

C. Hennekens, Y. Chao, S. Hsia, 1975, The Lancet.

Hepatic catabolism of rat and human lipoproteins in rats treated with 17 alpha-ethinyl estradiol.

Y. Chao, R. Havel, E. Windler, 1979, The Journal of biological chemistry.

Deficiency in sPLA(2) does not affect HDL levels or atherosclerosis in mice.

Y. Chao, S. Wright, P. Detmers, 2002, Biochemical and biophysical research communications.

A target for cholesterol absorption inhibitors in the enterocyte brush border membrane.

Y. Chao, J. Lisnock, B. Pikounis, 2000, Biochimica et biophysica acta.

Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors.

C. Chen, Y. Chao, Szu-Huei Wu, 2019, Bioorganic chemistry.

Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2.

C. Chen, Y. Chao, Szu-Huei Wu, 2018, European journal of medicinal chemistry.

Hepatic responses to inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase: a comparison of atorvastatin and simvastatin.

Y. Chao, S. Wright, W. Geissler, 1998, Biochimica et biophysica acta.

Regulation of hepatic receptor-dependent degradation of LDL by mevinolin in rabbits with hypercholesterolemia induced by a wheat starch-casein diet.

Y. Chao, T. Yamin, A. Alberts, 1983, Biochimica et biophysica acta.

Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91.

C. Chen, Y. Chao, Chin-Tarng Lin, 2010, Pharmacological research.

(1,3-Diphenyl-1H-pyrazol-4-yl)-methylamine Analogues as Inhibitors of Dipeptidyl Peptidases

C. Chen, Xin Chen, Y. Chao, 2009 .

Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors.

C. Chen, Xin Chen, Y. Chao, 2009, Bioorganic & medicinal chemistry.

Secretion of cholesteryl-ester-rich lipoproteins by the perfused livers of rabbits fed a wheat-starch-casein diet.

Y. Chao, J. Seidenberg, T. Yamin, 1986, Biochimica et biophysica acta.

Effects of cholestyramine on low density lipoprotein binding sites on liver membranes from rabbits with endogenous hypercholesterolemia induced by a wheat starch-casein diet.

Y. Chao, T. Yamin, A. Alberts, 1982, The Journal of biological chemistry.

Enhanced oral bioavailability of paclitaxel by D-alpha-tocopheryl polyethylene glycol 400 succinate in mice.

C. Chen, Y. Chao, T. Yeh, 2008, International journal of pharmaceutics.

Autoradiographic localization of the sites of uptake, cellular transport, and catabolism of low density lipoproteins in the liver of normal and estrogen-treated rats.

Y. Chao, R. Havel, A. Jones, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Resistance Studies of a Dithiazol Analogue, DBPR110, as a Potential Hepatitis C Virus NS5A Inhibitor in Replicon Systems

A. Yueh, Y. Chao, Su-Ying Wu, 2012, Antimicrobial Agents and Chemotherapy.

ApoE(-/-) mice develop atherosclerosis in the absence of complement component C5.

Y. Chao, S. Wright, P. Detmers, 2001, Biochemical and biophysical research communications.

Rapid and sensitive determination of fentanyl in dog plasma by on-line solid-phase extraction integrated with a hydrophilic column coupled to tandem mass spectrometry.

Y. Chao, T. Yeh, H. Yao, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

A fluorescent cholesterol analog traces cholesterol absorption in hamsters and is esterified in vivo and in vitro.

Y. Chao, S. Wright, P. Detmers, 1999, Journal of lipid research.

Infectious Agents Are Not Necessary for Murine Atherogenesis

Y. Chao, S. Wright, P. Detmers, 2000, The Journal of experimental medicine.

Identification of phenanthroindolizines and phenanthroquinolizidines as novel potent anti-coronaviral agents for porcine enteropathogenic coronavirus transmissible gastroenteritis virus and human severe acute respiratory syndrome coronavirus

Y. Chao, J. Jan, Shiow-Ju Lee, 2010, Antiviral Research.

BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML

Y. Chao, W. Jiaang, C-W Chen, 2011, British Journal of Cancer.

Isolation and characterization of a full-length rabbit apolipoprotein E cDNA.

Y. Chao, T. Yamin, P. Kroon, 1987, Atherosclerosis.

Discovery of novel N-β-D-xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes.

C. Chen, Y. Chao, Chieh-Jui Hsieh, 2011, Journal of medicinal chemistry.

4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy.

Y. Chao, Su-Ying Wu, Jen‐Shin Song, 2018, Bioorganic chemistry.

Design and Synthesis of α-Aryloxyphenylacetic Acid Derivatives: A Novel Class of PPARα/γ Dual Agonists with Potent Antihyperglycemic and Lipid Modulating Activity

Y. Chao, J. Berger, D. Moller, 2005 .

Intestinal absorption of cholesterol is mediated by a saturable, inhibitable transporter.

Y. Chao, S. Wright, P. Detmers, 2000, Biochimica et biophysica acta.

BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy

C. Chen, Y. Chao, T. Yeh, 2019, Translational oncology.

27 Hepatic responses to inhibition of HMG-CoA reductase: a comparison of atorvastatin and simvastatin

Y. Chao, S. Wright, J. Bergstrom, 1997 .

The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2',4'-dimethyl-4,5'-bi-1,3-thiazol-2-amines and naloxone.

C. Chen, Y. Chao, H. Loh, 2019, European journal of medicinal chemistry.

The first total synthesis of cytopiloyne, an anti-diabetic, polyacetylenic glucoside.

Y. Chao, Jinq-chyi Lee, Chi-Hui Tsai, 2011, Chemistry.

Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor.

Xin Chen, Y. Chao, Chih-Hsiang Huang, 2009, Biochemical pharmacology.

Analogues of 2-phenyl-ethenesulfonic acid phenyl ester have dual functions of inhibiting expression of inducible nitric oxide synthase and activating peroxisome proliferator-activated receptor gamma.

Y. Chao, Shiow-Ju Lee, Iou-Jiun Kang, 2008, Bioorganic & medicinal chemistry letters.

(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.

C. Chen, Xin Chen, Y. Chao, 2010, Bioorganic & medicinal chemistry letters.

Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors.

C. Chen, Xin Chen, Y. Chao, 2009, Bioorganic & medicinal chemistry letters.

Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations.

C. Chen, Y. Chao, J. Hsu, 2015, European journal of medicinal chemistry.

Synthesis of 3,3-Dimethylglutamic Acid Derivatives as DPP-IV Inhibitors and Evaluation of Their Chemical Stability

Y. Chao, T. Hsu, W. Jiaang, 2011 .

Aurora kinase A inhibitors: identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold.

H. Hsieh, Y. Chao, J. Hsu, 2008, Bioorganic & medicinal chemistry letters.

Biotransformation of 6-Methoxy-3-(3′,4′,5′-trimethoxy-benzoyl)-1H-indole (BPR0L075), a Novel Antimicrotubule Agent, by Mouse, Rat, Dog, and Human Liver Microsomes

H. Hsieh, C. Chen, Y. Chao, 2007, Drug Metabolism and Disposition.

Structural Basis for the Improved Potency of Peroxisome Proliferator‐Activated Receptor (PPAR) Agonists

Ping-Chiang Lyu, Mohane Selvaraj Coumar, Chien-Fu Huang, 2010, ChemMedChem.

Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors.

A. Yueh, Y. Chao, S. Shih, 2011, Bioorganic & medicinal chemistry letters.

Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives.

H. Hsieh, C. Liao, Y. Chao, 2010, Journal of medicinal chemistry.

Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists.

Y. Chao, Jen‐Shin Song, Kak‐Shan Shia, 2008, Journal of medicinal chemistry.

Researchcompound BPR1P0034 with potent and selective anti-influenza virus activity

H. Hsieh, Y. Chao, Hsiu-Ling Chen, 2010 .

Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity

H. Hsieh, Y. Chao, Hsiu-Ling Chen, 2010, Journal of Biomedical Science.

Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity.

Ping-Chiang Lyu, Mohane Selvaraj Coumar, Yu-Sheng Chao, 2009, Journal of medicinal chemistry.

Synthesis and biological evaluation of tylophorine-derived dibenzoquinolines as orally active agents: exploration of the role of tylophorine e ring on biological activity.

Y. Chao, Shiow-Ju Lee, T. Yeh, 2012, Journal of medicinal chemistry.

Discovery of 1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced o

Y. Chao, Jen‐Shin Song, T. Yeh, 2013, Journal of medicinal chemistry.

Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

C. Chen, Y. Chao, J. Hsu, 2011, Bioorganic & medicinal chemistry.

Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and Michael acceptor group for maximal potency.

Sing-Yi Wang, Mohane Selvaraj Coumar, Yu-Sheng Chao, 2010, Journal of medicinal chemistry.

(2R)-2-Ethylchromane-2-carboxylic Acids: Discovery of Novel PPARα/γ Dual Agonists as Antihyperglycemic and Hypolipidemic Agents

Margaret S. Wu, Y. Chao, J. Berger, 2004 .

3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

C. Chen, Y. Chao, J. Hsu, 2012, Bioorganic & medicinal chemistry letters.

Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies.

Thy-Hou Lin, Po-Huang Liang, I-Lin Lu, 2006, Journal of medicinal chemistry.

Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine Aurora kinase inhibitor.

H. Hsieh, C. Chen, Y. Chao, 2013, Journal of medicinal chemistry.

Bioassay‐guided purification and identification of PPARα/γ agonists from Chlorella sorokiniana

Chien-Fu Huang, H. Hsieh, T. Lien, 2008, Phytotherapy research : PTR.

Inhibition of Severe Acute Respiratory Syndrome Coronavirus Replication by Niclosamide

H. Hsieh, Y. Chao, J. Hsu, 2004, Antimicrobial Agents and Chemotherapy.

Cholesterol-lowering effect of mevinolin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme a reductase, in healthy volunteers.

Y. Chao, J. Bolognese, G. Bell, 1982, The Journal of clinical investigation.

Mutation in Enterovirus 71 Capsid Protein VP1 Confers Resistance to the Inhibitory Effects of Pyridyl Imidazolidinone

Y. Chao, Guang-Wu Chen, S. Shih, 2004, Antimicrobial Agents and Chemotherapy.

Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: application to a pharmacokinetic study.

H. Hsieh, C. Chen, Y. Chao, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

MK-0767, a novel dual PPARα/γ agonist, displays robust antihyperglycemic and hypolipidemic activities

Margaret S. Wu, Y. Chao, J. Berger, 2004 .

Targeting Coronaviral Replication and Cellular JAK2 Mediated Dominant NF-κB Activation for Comprehensive and Ultimate Inhibition of Coronaviral Activity

Y. Chao, C. Shih, Hwan-You Chang, 2017, Scientific Reports.

c-Jun-mediated anticancer mechanisms of tylophorine.

Y. Chao, Hwan-You Chang, Shiow-Ju Lee, 2013, Carcinogenesis.

Targeting Nanoparticle Probes to Differentiating Stem Cells

Y. Chao, E. Ruoslahti, J. Price, 2008 .

Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

Chi-Ying F. Huang, Yi-Hui Peng, H. Hsieh, 2013, Proceedings of the National Academy of Sciences.

EGFR and myosin II inhibitors cooperate to suppress EGFR‐T790M‐mutant NSCLC cells

Y. Chao, J. Hsu, Chin-Ting Huang, 2012, Molecular oncology.

Identification, SAR Studies, and X‐ray Co‐crystallographic Analysis of a Novel Furanopyrimidine Aurora Kinase A Inhibitor

H. Hsieh, Y. Chao, J. Hsu, 2010, ChemMedChem.

Putative tumor metastasis-associated genes in human gastric cancer.

Hsiao-Hui Tsou, Cheng-Ta Chung, Wen-Sen Lee, 2012, International journal of oncology.

Inhibition of HIV-1 Tat-Mediated Transcription by a Coumarin Derivative, BPRHIV001, through the Akt Pathway

H. Hsieh, Y. Chao, Sui‐Yuan Chang, 2011, Journal of Virology.

Apolipoprotein E-Deficient Mice Results in Reduced Atherosclerosis in Deficiency in Inducible Nitric Oxide Synthase

D. Rader, E. Puré, Y. Chao, 2000 .

BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses.

H. Hsieh, Y. Chao, L. Poon, 2010, The Journal of antimicrobial chemotherapy.

Antiangiogenic activities and cisplatin-combined antitumor activities of BPR0L075.

H. Hsieh, C. Chen, Y. Chao, 2010, Anticancer research.

Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein.

Xin Chen, Y. Chao, Jen‐Shin Song, 2010, Journal of medicinal chemistry.

Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists.

Y. Chao, H. Loh, P. Law, 2014, Bioorganic & medicinal chemistry.

High fat fed hamster, a unique animal model for treatment of diabetic dyslipidemia with peroxisome proliferator activated receptor alpha selective agonists.

Y. Chao, M. Wu, J. Ventre, 2001, European journal of pharmacology.

LIQUID CHROMATOGRAPHIC DETERMINATION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE INHIBITORS

Y. Chao, M. Shiao, V. Hunt, 1996 .

Regulation of the hepatic uptake of triglyceride-rich lipoproteins in the rat. Opposing effects of homologous apolipoprotein E and individual C apoproteins.

R J Havel, Y. Chao, R. Havel, 1980, The Journal of biological chemistry.

Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity.

Y. Chao, J. Berger, D. Moller, 2005, Journal of medicinal chemistry.

BPR0C305, an orally active microtubule-disrupting anticancer agent

Chi-Hung Lin, C. Chen, Y. Chao, 2013, Anti-cancer drugs.

Bioisosteric replacement of the pyrazole 3-carboxamide moiety of rimonabant. A novel series of oxadiazoles as CB1 cannabinoid receptor antagonists.

Y. Chao, Jen‐Shin Song, Kak‐Shan Shia, 2008, Organic & biomolecular chemistry.

Evaluation of the Antitumor Effects of BPR1J-340, a Potent and Selective FLT3 Inhibitor, Alone or in Combination with an HDAC Inhibitor, Vorinostat, in AML Cancer

C. Chen, Y. Chao, T. Yeh, 2014, PloS one.

PPARα Agonists Reduce 11β-Hydroxysteroid Dehydrogenase Type 1 in the Liver

Margaret S. Wu, D. Gerhold, R. Thieringer, 2000 .

Discovery of 1‐(2,4‐Dichlorophenyl)‐4‐ethyl‐5‐(5‐(2‐(4‐(trifluoromethyl)phenyl)ethynyl)thiophen‐2‐yl)‐N‐(piperidin‐1‐yl)‐1H‐pyrazole‐3‐carboxamide as a Potential Peripheral Cannabinoid‐1 Receptor Inverse Agonist

Y. Chao, Jen‐Shin Song, T. Yeh, 2010, ChemMedChem.

Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies.

Ping-Chiang Lyu, I-Lin Lu, Ying-Ting Lin, 2006, Journal of medicinal chemistry.

Isolation and Biological Activities of Phenanthroindolizidine and Septicine Alkaloids from the Formosan Tylophora ovata

Y. Chao, Hwan-You Chang, Shiow-Ju Lee, 2011, Planta medica.

Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents

Chi-Hung Lin, C. Chen, T. Lien, 2012, Investigational new drugs.

A Novel Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist Demonstrates Favorable Effects on Lipid Homeostasis

Margaret S. Wu, Y. Chao, J. Berger, 2004 .

PPARalpha agonists reduce 11beta-hydroxysteroid dehydrogenase type 1 in the liver.

D. Gerhold, R. Thieringer, Y. Chao, 2000, Biochemical and biophysical research communications.

Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities.

I-Lin Lu, Chien-Fu Huang, Yu-Sheng Chao, 2005, Journal of medicinal chemistry.

Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity.

Mohane Selvaraj Coumar, Yu-Sheng Chao, Su-Ying Wu, 2009, Journal of medicinal chemistry.

Resistance Analysis and Characterization of a Thiazole Analogue, BP008, as a Potent Hepatitis C Virus NS5A Inhibitor

A. Yueh, Y. Chao, T. Yeh, 2011, Antimicrobial Agents and Chemotherapy.

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 9. The synthesis and biological evaluation of novel simvastatin analogs.

Y. Chao, A. Alberts, G. Hartman, 1992, Journal of Medicinal Chemistry.

Characterization of an efficient dengue virus replicon for development of assays of discovery of small molecules against dengue virus.

A. Yueh, Y. Chao, Szu-Huei Wu, 2013, Antiviral research.

Beta-very low density lipoproteins in cholesterol-fed rabbits are of hepatic origin.

Y. Chao, P. Kroon, G. M. Thompson, 1985, Atherosclerosis.

Tissue-specific expression of genes encoding apolipoprotein E and apolipoprotein A-I in rabbits.

Y. Chao, T. Yamin, P. Kroon, 1984, The Journal of biological chemistry.

3-[2-((2S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes.

H. Hsieh, C. Chen, Xin Chen, 2007, Bioorganic & medicinal chemistry letters.

3D‐QSAR‐Assisted Drug Design: Identification of a Potent Quinazoline‐Based Aurora Kinase Inhibitor

Yung Chang Hsu, H. Hsieh, Y. Chao, 2013, ChemMedChem.

Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling

Y. Chao, H. Loh, P. Law, 2014, Nucleic acids research.

Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists.

Ping-Chiang Lyu, I-Lin Lu, Yu-Sheng Chao, 2007, Journal of medicinal chemistry.

Discovery of Novel Stem Cell Mobilizers That Target the CXCR4 Receptor

C. Chen, Y. Chao, Su-Ying Wu, 2012, ChemMedChem.

Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

C. Chen, Y. Chao, J. Hsu, 2013, Bioorganic & medicinal chemistry.

Tylophorine arrests carcinoma cells at G1 phase by downregulating cyclin A2 expression.

Y. Chao, Shiow-Ju Lee, P. Wu, 2009, Biochemical and biophysical research communications.

Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice.

Y. Chao, Jen‐Shin Song, T. Yeh, 2009, Journal of medicinal chemistry.

BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses.

H. Hsieh, Y. Chao, L. Poon, 2010, The Journal of antimicrobial chemotherapy.

Molecular cloning of partial cDNAs for rabbit liver apolipoprotein B and the regulation of its mRNA levels by dietary cholesterol.

Y. Chao, P. Kroon, G. M. Thompson, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Biphasic suppression of appetite by cannabinoid CB1 receptor antagonists with distinct functional activities.

Y. Chao, T. Yeh, Kak‐Shan Shia, 2010, Pharmacological research.

Phenobarbital induces rat liver apolipoprotein A-I mRNA.

Y. Chao, C. B. Pickett, T. Yamin, 1985, Molecular pharmacology.

Catabolism of low density lipoproteins by perfused rabbit livers: cholestyramine promotes receptor-dependent hepatic catabolism of low density lipoproteins.

Y. Chao, T. Yamin, A. Alberts, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

Chi-Ying F. Huang, Yi-Hui Peng, H. Hsieh, 2013, Proceedings of the National Academy of Sciences.