J. Hsu

发表

Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities.

I. Lu, Chien-Fu Huang, Yi-Hui Peng, 2006, Journal of medicinal chemistry.

Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening.

Yi-Hui Peng, A. Yueh, J. Hsu, 2015, Journal of medicinal chemistry.

Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: the role of the DFG motif in the design of epidermal growth factor receptor inhibitors.

P. Lyu, Yi-Hui Peng, H. Hsieh, 2013, Journal of medicinal chemistry.

Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification.

Santhosh Kumar Chittimalla, Yi-Hui Peng, H. Hsieh, 2010, Journal of medicinal chemistry.

Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains

J. Hsu, Jinn-Moon Yang, K. Hsu, 2017, Scientific Reports.

Antiviral drug discovery against SARS-CoV.

H. Hsieh, J. Hsu, Yu-Shan Wu, 2006, Current medicinal chemistry.

Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells.

H. Hsieh, J. Hsu, S. Chuang, 2007, Cancer letters.

Development of NS3/4A Protease-Based Reporter Assay Suitable for Efficiently Assessing Hepatitis C Virus Infection

J. Hsu, H. Sung, Jin-Ching Lee, 2009, Antimicrobial Agents and Chemotherapy.

Development of NS 3 / 4 A protease-based reporter assay suitable for efficiently assessing hepatitis C virus infection

J. Hsu, H. Sung, Jin-Ching Lee, 2009 .

Synergistic inhibition of enterovirus 71 replication by interferon and rupintrivir.

J. Hsu, S. Shih, Hui-Chen Hung, 2011, The Journal of infectious diseases.

Identification of ligand efficient, fragment-like hits from an HTS library: structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity

Mohane Selvaraj Coumar, Yi-Yu Ke, Sailu Sarvagalla, 2014, Journal of Computer-Aided Molecular Design.

Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification

Yung Chang Hsu, H. Hsieh, J. Hsu, 2015, Scientific Reports.

A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors.

H. Hsieh, T. Lien, Y. Chao, 2008, Analytical biochemistry.

Ligand efficiency based approach for efficient virtual screening of compound libraries.

H. Hsieh, J. Hsu, Szu-Huei Wu, 2014, European journal of medicinal chemistry.

Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors.

H. Hsieh, J. Hsu, M. Coumar, 2020, Bioorganic chemistry.

A mammalian cell-based reverse two-hybrid system for functional analysis of 3C viral protease of human enterovirus 71.

Y. Chao, J. Hsu, Jim-Min Fang, 2008, Analytical biochemistry.

Generation of chimeric baculovirus with histidine-tags displayed on the envelope and its purification using immobilized metal affinity chromatography

J. Hsu, Yu-Chen Hu, Chien-Tai Tsai, 2003 .

A high-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors.

H. Hsieh, T. Lien, Y. Chao, 2012, Anticancer research.

The Combination Effects of LiCl and the Active Leflunomide Metabolite, A771726, on Viral-Induced Interleukin 6 Production and EV-A71 Replication

J. Hsu, S. Shih, M. Fang, 2014, PloS one.

Inhibition of enterovirus 71 replication and the viral 3D polymerase by aurintricarboxylic acid

J. Hsu, S. Shih, Tzu-Chun Chen, 2010, The Journal of antimicrobial chemotherapy.

Evaluation of metal‐conjugated compounds as inhibitors of 3CL protease of SARS‐CoV

H. Hsieh, Xin Chen, J. Hsu, 2004, FEBS Letters.

Emergence of mutation clusters in the HCV genome during sequential viral passages in Sip-L expressing cells.

J. Hsu, C. Yeh, Ming-Ling Chang, 2005, Journal of virological methods.

Mycotoxin Patulin Suppresses Innate Immune Responses by Mitochondrial Dysfunction and p62/Sequestosome-1-dependent Mitophagy *

J. Hsu, Jinq-chyi Lee, Chia-Yang Li, 2016, The Journal of Biological Chemistry.

Effect of a Neuropilin-1-Derived Virus Receptor Trap on Enterovirus A71 Infection In Vitro

J. Hsu, Peng-Nien Huang, S. Shih, 2020, Antimicrobial Agents and Chemotherapy.

Purification and characterization of human prolyl dipeptidase DPP8 in Sf9 insect cells.

C. Goparaju, Xin Chen, J. Hsu, 2004, Protein expression and purification.

BPR1K653, a Novel Aurora Kinase Inhibitor, Exhibits Potent Anti-Proliferative Activity in MDR1 (P-gp170)-Mediated Multidrug-Resistant Cancer Cells

H. Hsieh, T. Lien, J. Hsu, 2011, PloS one.

Zika Virus NS3 Protease Pharmacophore Anchor Model and Drug Discovery

J. Hsu, Jinn-Moon Yang, Guann-Yi Yu, 2020, Scientific Reports.

Identification of danthron as an isoform-specific inhibitor of HEME OXYGENASE-1/cytochrome P450 reductase interaction with anti-tumor activity

J. Hsu, Y. Hsu, F. Hsu, 2018, Journal of Biomedical Science.

Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations.

C. Chen, Y. Chao, J. Hsu, 2015, European journal of medicinal chemistry.

Aurora kinase A inhibitors: identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold.

H. Hsieh, Y. Chao, J. Hsu, 2008, Bioorganic & medicinal chemistry letters.

Notice of RetractionDisulfiram is a Novel Modulator for PPAR

Chien-Fu Huang, T. Lien, J. Hsu, 2011, 2011 5th International Conference on Bioinformatics and Biomedical Engineering.

Novel Antiviral Agent DTriP-22 Targets RNA-Dependent RNA Polymerase of Enterovirus 71

J. Hsu, Hwan-You Chang, S. Shih, 2009, Antimicrobial Agents and Chemotherapy.

Strategies of development of antiviral agents directed against influenza virus replication.

H. Hsieh, J. Hsu, 2007, Current pharmaceutical design.

Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system.

H. Hsieh, T. Lien, J. Hsu, 2006, Bioorganic & medicinal chemistry.

Structural Basis for the Improved Potency of Peroxisome Proliferator‐Activated Receptor (PPAR) Agonists

Ping-Chiang Lyu, Mohane Selvaraj Coumar, Chien-Fu Huang, 2010, ChemMedChem.

Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

C. Chen, Y. Chao, J. Hsu, 2011, Bioorganic & medicinal chemistry.

Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and Michael acceptor group for maximal potency.

Sing-Yi Wang, Mohane Selvaraj Coumar, Yu-Sheng Chao, 2010, Journal of medicinal chemistry.

3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

C. Chen, Y. Chao, J. Hsu, 2012, Bioorganic & medicinal chemistry letters.

Development of a cell-based assay for monitoring specific hepatitis C virus NS3/4A protease activity in mammalian cells.

J. Hsu, S. Hsu, Jin-Ching Lee, 2003, Analytical biochemistry.

Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine Aurora kinase inhibitor.

H. Hsieh, C. Chen, Y. Chao, 2013, Journal of medicinal chemistry.

Anti-HSV activity of digitoxin and its possible mechanisms.

H. Hsieh, J. Hsu, Chun-Nan Lee, 2008, Antiviral research.

Diosgenin, a plant-derived sapogenin, exhibits antiviral activity in vitro against hepatitis C virus.

J. Hsu, Wen-Hsing Lin, Kao-Lu Pan, 2011, Journal of natural products.

Bioassay‐guided purification and identification of PPARα/γ agonists from Chlorella sorokiniana

Chien-Fu Huang, H. Hsieh, T. Lien, 2008, Phytotherapy research : PTR.

Epstein-Barr Virus BALF3 Has Nuclease Activity and Mediates Mature Virion Production during the Lytic Cycle

J. Hsu, K. Takada, Chung S. Yang, 2014, Journal of Virology.

Formation of enterovirus-like particle aggregates by recombinant baculoviruses co-expressing P1 and 3CD in insect cells

J. Hsu, M. Ho, Yu-Chen Hu, 2003, Biotechnology Letters.

Inhibition of Severe Acute Respiratory Syndrome Coronavirus Replication by Niclosamide

H. Hsieh, Y. Chao, J. Hsu, 2004, Antimicrobial Agents and Chemotherapy.

Inhibition of Hepatitis C Virus Replication by Arsenic Trioxide

Jeng-Min Chiou, Ying-Ting Lin, J. Hsu, 2004, Antimicrobial Agents and Chemotherapy.

Inhibition of authentic hepatitis C virus replication by sodium stibogluconate.

J. Hsu, C. Yeh, Der-Ren Hwang, 2003, Biochemical and biophysical research communications.

BPR-3P0128 inhibits RNA-dependent RNA polymerase elongation and VPg uridylylation activities of Enterovirus 71.

H. Hsieh, J. Hsu, J. Horng, 2014, Antiviral research.

Inhibition of Hepatitis C Virus Replication by Antimonial Compounds

T. Lien, J. Hsu, C. Yeh, 2005, Antimicrobial Agents and Chemotherapy.

High-throughput cell-based screening for hepatitis C virus NS3/4A protease inhibitors.

T. Lien, J. Hsu, Jin-Ching Lee, 2005, Assay and drug development technologies.

Papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV): expression, purification, characterization, and inhibition.

Xin Chen, J. Hsu, S. Yeh, 2005, Biochemistry.

Enhanced recombinant protein production and differential expression of molecular chaperones in sf-caspase-1-repressed stable cells after baculovirus infection

J. Hsu, Y. Lai, Kao-Lu Pan, 2012, BMC Biotechnology.

A Novel Aurora-A Inhibitor, BPR1K0609S1, Sensitizes Colorectal Tumor cells to 5-Fluorofracil (5-FU) Treatment

T. Ouchi, H. Hsieh, J. Hsu, 2013, International Journal of Biological Sciences.

A Novel Aurora-A Inhibitor, BPR1K0609S1, Sensitizes Colorectal Tumor cells to 5-Fluorofracil (5-FU) Treatment

T. Ouchi, H. Hsieh, J. Hsu, 2013, International journal of biological sciences.

Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

Chi-Ying F. Huang, Yi-Hui Peng, H. Hsieh, 2013, Proceedings of the National Academy of Sciences.

Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design.

Wen-Chieh Wang, Wen-Hsing Lin, Hsing-Pang Hsieh, 2016, European journal of medicinal chemistry.

Facile Identification of Dual FLT3–Aurora A Inhibitors: A Computer‐Guided Drug Design Approach

H. Hsieh, J. Hsu, Yi-Yu Ke, 2014, ChemMedChem.

BPR1J373, an Oral Multiple Tyrosine Kinase Inhibitor, Targets c-KIT for the Treatment of c-KIT–Driven Myeloid Leukemia

C. Chen, J. Hsu, Li‐Tzong Chen, 2016, Molecular Cancer Therapeutics.

EGFR and myosin II inhibitors cooperate to suppress EGFR‐T790M‐mutant NSCLC cells

Y. Chao, J. Hsu, Chin-Ting Huang, 2012, Molecular oncology.

Identification, SAR Studies, and X‐ray Co‐crystallographic Analysis of a Novel Furanopyrimidine Aurora Kinase A Inhibitor

H. Hsieh, Y. Chao, J. Hsu, 2010, ChemMedChem.

Mutations at KFRDI and VGK domains of enterovirus 71 3C protease affect its RNA binding and proteolytic activities.

J. Hsu, M. Hwang, Mei-Ling Li, 2004, Journal of biomedical science.

Mutations at KFRDI and VGK Domains of Enterovirus 71 3C Protease Affect Its RNA Binding and Proteolytic Activities

J. Hsu, M. Hwang, Mei-Ling Li, 2004, Journal of Biomedical Science.

Zika Virus NS3 Protease Pharmacophore Anchor Model and Drug Discovery

J. Hsu, Jinn-Moon Yang, Guann-Yi Yu, 2020, Scientific Reports.

Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents

J. Hsu, Shih-Cheng Chang, Jim-Min Fang, 2008, Bioorganic & Medicinal Chemistry.

Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation

Yung Chang Hsu, C. Chen, J. Hsu, 2016, Oncotarget.

Anchor-based classification and type-C inhibitors for tyrosine kinases

J. Hsu, Jinn-Moon Yang, Y. Chiu, 2015, Scientific Reports.

Antiviral Activity of a Llama-Derived Single-Domain Antibody against Enterovirus A71

Min-Yuan Chou, J. Hsu, Peng-Nien Huang, 2020, Antimicrobial Agents and Chemotherapy.

Identification of Novel Cdc7 Kinase Inhibitors as Anti-Cancer Agents that Target the Interaction with Dbf4 by the Fragment Complementation and Drug Repositioning Approach

J. Hsu, A. Lee, Chun-Hua Hsu, 2018, EBioMedicine.

Fractionation of purified nucleosomes on the basis of aggregation properties.

J. Hsu, M. Sanders, 1977, Biochemistry.

Identification of BPR3P0128 as an Inhibitor of Cap-Snatching Activities of Influenza Virus

H. Hsieh, J. Hsu, Ta-Jen Lin, 2011, Antimicrobial Agents and Chemotherapy.

Characterization of SARS main protease and inhibitor assay using a fluorogenic substrate

J. Hsu, P. Liang, C. Kuo, 2004, Biochemical and Biophysical Research Communications.

Anti-HCV activities of selective polyunsaturated fatty acids.

J. Hsu, Tiao-Yin Lin, Guang-Zhou Leu, 2004, Biochemical and biophysical research communications.

Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies.

Ping-Chiang Lyu, I-Lin Lu, Ying-Ting Lin, 2006, Journal of medicinal chemistry.

Bispecific Antibody Conjugated Manganese-Based Magnetic Engineered Iron Oxide for Imaging of HER2/neu- and EGFR-Expressing Tumors

Min-Yuan Chou, J. Hsu, M. Hou, 2016, Theranostics.

Development of an anti-influenza drug screening assay targeting nucleoproteins with tryptophan fluorescence quenching.

J. Hsu, Su-Ying Wu, J. Horng, 2012, Analytical chemistry.

Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3′-digallate (TF3)

Po-Huang Liang, Coney P. C. Lin, H. Hsieh, 2005, Evidence-based complementary and alternative medicine : eCAM.

Using mutagenesis to explore conserved residues in the RNA-binding groove of influenza A virus nucleoprotein for antiviral drug development

J. Hsu, M. Hou, Hui-Chen Hung, 2016, Scientific Reports.

Development of a whole‐cell screening system for evaluation of the human CYP1A2‐mediated metabolism

J. Hsu, H. Yao, Kao-Lu Pan, 2011, Biotechnology and bioengineering.

A reporter-based assay for identifying hepatitis C virus inhibitors based on subgenomic replicon cells.

Der-Ren Hwang, J. Hsu, Jin-Ching Lee, 2004, Journal of virological methods.

Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity.

Mohane Selvaraj Coumar, Yu-Sheng Chao, Su-Ying Wu, 2009, Journal of medicinal chemistry.

Discovery of M Protease Inhibitors Encoded by SARS-CoV-2

C. Chen, J. Hsu, Szu-Huei Wu, 2020, Antimicrobial Agents and Chemotherapy.

Characterization of a segmented double-stranded RNA virus in Drosophila Kc cells.

J. Hsu, M. Sanders, 1983, Nucleic acids research.

3D‐QSAR‐Assisted Drug Design: Identification of a Potent Quinazoline‐Based Aurora Kinase Inhibitor

Yung Chang Hsu, H. Hsieh, Y. Chao, 2013, ChemMedChem.

Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists.

Ping-Chiang Lyu, I-Lin Lu, Yu-Sheng Chao, 2007, Journal of medicinal chemistry.

Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

C. Chen, Y. Chao, J. Hsu, 2013, Bioorganic & medicinal chemistry.

Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

Chi-Ying F. Huang, Yi-Hui Peng, H. Hsieh, 2013, Proceedings of the National Academy of Sciences.

Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists.

Mohane Selvaraj Coumar, Yu-Sheng Chao, Su-Ying Wu, 2009, Journal of medicinal chemistry.