J. Holenz

发表

Medicinal chemistry strategies to 5-HT(6) receptor ligands as potential cognitive enhancers and antiobesity agents.

J. Holenz, P. Pauwels, J. Díaz, 2006, Drug discovery today.

Synthesis and biological evaluation of the 1-arylpyrazole class of σ(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862).

D. Zamanillo, C. Laggner, J. Holenz, 2012, Journal of medicinal chemistry.

Microwave assisted synthesis of spirocyclic pyrrolidines -σ1 receptor ligands with modified benzene-N-distance.

J. Holenz, H. Buschmann, B. Wünsch, 2012, European journal of medicinal chemistry.

Combination of two pharmacophoric systems: synthesis and pharmacological evaluation of spirocyclic pyranopyrazoles with high σ₁ receptor affinity.

J. Holenz, H. Buschmann, B. Wünsch, 2011, Journal of medicinal chemistry.

A Medicinal‐Chemistry‐Guided Approach to Selective and Druglike Sigma 1 Ligands

D. Zamanillo, J. Holenz, H. Buschmann, 2006, ChemMedChem.

Pharmacological and metabolic characterisation of the potent σ1 receptor ligand 1′‐benzyl‐3‐methoxy‐3H‐spiro[[2]benzofuran‐1,4′‐piperidine]

J. Holenz, H. Buschmann, B. Wünsch, 2009 .

Modern Lead Generation Strategies

J. Holenz, Dean G. Brown, 2016 .

Thiophene bioisosteres of spirocyclic σ receptor ligands: relationships between substitution pattern and σ receptor affinity.

J. Holenz, H. Buschmann, B. Wünsch, 2012, Journal of medicinal chemistry.

Chronic 5‐HT6 receptor modulation by E‐6837 induces hypophagia and sustained weight loss in diet‐induced obese rats

J. Holenz, P. Pauwels, R. Mercé, 2006, British journal of pharmacology.

Competitive Intelligence–based Lead Generation and Fast Follower Approaches

Yu Jiang, Hua Yang, Ziping Liu, 2016 .

‘Biomimetic’ oxidative dimerization of korupensamine A: Completion of the first total synthesis of michellamines A, B, and C

M. Boyd, J. Holenz, G. Bringmann, 1994 .

Biotransformation of Two b -Secretase Inhibitors Including Ring Opening and Contraction of a Pyrimidine Ring s

J. Holenz, J. Malmquist, B. Swahn, 2013 .

Toward β-Secretase-1 Inhibitors with Improved Isoform Selectivity.

Clay W Scott, R. Bürli, J. Holenz, 2018, Journal of medicinal chemistry.

Synthesis and Pharmacological Evaluation of a Potent and Selective σ1 Receptor Antagonist with High Antiallodynic Activity

J. Holenz, H. Buschmann, B. Wünsch, 2011, Archiv der Pharmazie.

Synthesis of sigma receptor ligands with unsymmetrical spiro connection of the piperidine moiety.

J. Holenz, H. Buschmann, B. Wünsch, 2009, European journal of medicinal chemistry.

Structural-activity relationship study on C-4 carbon atom of the CB1 antagonist SR141716: synthesis and pharmacological evaluation of 1,2,4-triazole-3-carboxamides.

J. Holenz, J. Frigola, I. Alkorta, 2006, European journal of medicinal chemistry.

Sulfonimidamides as Sulfonamides Bioisosteres: Rational Evaluation through Synthetic, in Vitro, and in Vivo Studies with γ‐Secretase Inhibitors

J. Holenz, P. Arvidsson, J. Lundkvist, 2012, ChemMedChem.

Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.

J. Holenz, J. Díaz, R. Mercé, 2005, Journal of medicinal chemistry.

First synthesis of the antimalarial naphthylisoquinoline alkaloid dioncophylline C, and its unnatural anti-HIV dimer, jozimine C☆

M. Boyd, J. Holenz, G. Bringmann, 1998 .

Naphthylisoquinoline alkaloids against malaria: evaluation of the curative potentials of dioncophylline C and dioncopeltine A against Plasmodium berghei in vivo

J. Holenz, G. Bringmann, L. A. Assi, 1997, Antimicrobial agents and chemotherapy.

Growth Inhibition of Asexual Erythrocytic Forms of Plasmodium falciparum and P. berghei in vitro by Naphthylisoquinoline Alkaloid-Containing Extracts of Ancistrocladus and Triphyophyllum Species

J. Holenz, G. Bringmann, C. Zhao, 1997 .

Retarded development of exoerythrocytic stages of the rodent malaria parasite Plasmodium berghei in human hepatoma cells by extracts from Dioncophyllaceae and Ancistrocladaceae species.

J. Holenz, G. Bringmann, C. Zhao, 1997, International journal for parasitology.

In vitro inhibition of liver forms of the rodent malaria parasite Plasmodium berghei by naphthylisoquinoline alkaloids – structure-activity relationships of dioncophyllines A and C and ancistrocladine

Gerhard Bringmann, J. Holenz, G. Bringmann, 1997, Parasitology Research.

Larvicidal activity of the naphthylisoquinoline alkaloid dioncophylline A against the malaria vector Anopheles stephensi.

J. Holenz, G. Bringmann, G. François, 1996, Journal of ethnopharmacology.

Acetogenic Isoquinoline Alkaloids, LXXXII. Biomimetic Total Synthesis of Michellamines A–C

J. Holenz, G. Bringmann, Rainer Walter, 1996 .

Identification of novel indanylsulfonamide guanylhydrazones as potent 5-HT6 serotonin receptor antagonists.

J. Holenz, R. Mercé, J. Frigola, 2009, Journal of medicinal chemistry.

Antiplasmodial Activity of Mono- and Dimeric Carbazoles

J. Holenz, G. Bringmann, G. François, 1998, Planta medica.

Antimalarial and cytotoxic potential of four quassinoids from Hannoa chlorantha and Hannoa klaineana, and their structure-activity relationships.

J. Holenz, G. Bringmann, G. François, 1998, International journal for parasitology.

Constituents of Picralima nitida display pronounced inhibitory activities against asexual erythrocytic forms of Plasmodium falciparum in vitro.

J. Holenz, G. Bringmann, G. François, 1996, Journal of ethnopharmacology.

Vismione H and structurally related anthranoid compounds of natural and synthetic origin as promising drugs against the human malaria parasite Plasmodium falciparum: structure-activity relationships

J. Holenz, G. Bringmann, L. A. Assi, 1999, Parasitology Research.

Pharmacological and metabolic characterisation of the potent sigma1 receptor ligand 1'-benzyl-3-methoxy-3H-spiro[[2]benzofuran-1,4'-piperidine].

J. Holenz, H. Buschmann, B. Wünsch, 2009, The Journal of pharmacy and pharmacology.

Thiophene bioisosteres of spirocyclic sigma receptor ligands. 1. N-substituted spiro[piperidine-4,4'-thieno[3,2-c]pyrans].

J. Holenz, J. Díaz, B. Wünsch, 2008, Journal of medicinal chemistry.

Indene-based frameworks targeting the 5-HT6 serotonin receptor: ring constraint in indenylsulfonamides using cyclic amines and structurally abbreviated counterparts.

J. Holenz, R. Mercé, J. Frigola, 2009, Bioorganic & medicinal chemistry.

Molluscicidal Activity (Biomphalaria glabrata) of Dioncophylline A: Structure-Activity Investigations#

J. Holenz, G. Bringmann, K. Hostettmann, 1998, Planta medica.

Dioncophylline A as a growth-retarding agent against the herbivorous insect Spodoptera littoralis: structure-activity relationships.

J. Holenz, P. Proksch, G. Bringmann, 1997, Journal of natural products.

Molluscicidal Activity of Naphthylisoquinoline Alkaloids from Triphyophyllum and Ancistrocladus Species*

J. Holenz, G. Bringmann, C. Zhao, 1996, Planta medica.

Naphthylisoquinoline alkaloids exhibit strong growth-inhibiting activities against Plasmodium falciparum and P. berghei in vitro--structure-activity relationships of dioncophylline C.

J. Holenz, G. Bringmann, L. Maes, 1996, Annals of tropical medicine and parasitology.

Differential sensitivity of erythrocytic stages of the rodent malaria parasite Plasmodium chabaudi chabaudi to dioncophylline B, a highly active naphthylisoquinoline alkaloid

Gerhard Bringmann, J. Holenz, G. Bringmann, 1999, Parasitology Research.

Acetogenic Isoquinoline Alkaloids. Part 69. “Biomimetic” Oxidative Dimerization of Korupensamine A: Completion of the First Total Synthesis of Michellamines A, B, and C.

M. Boyd, J. Holenz, G. Bringmann, 2010 .

The small molecule CLP257 does not modify activity of the K+–Cl− co-transporter KCC2 but does potentiate GABAA receptor activity

R. J. Mather, N. Brandon, J. Holenz, 2017, Nature Medicine.

Aminoimidazoles as BACE-1 inhibitors: the challenge to achieve in vivo brain efficacy.

Britt-Marie Swahn, Margareta Ek, Johan Lindström, 2012, Bioorganic & medicinal chemistry letters.

Design and synthesis of β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors with in vivo brain reduction of β-amyloid peptides.

Britt-Marie Swahn, Johan Lindström, Stefan Berg, 2012, Journal of medicinal chemistry.

Biotransformation of Two β-Secretase Inhibitors Including Ring Opening and Contraction of a Pyrimidine Ring

J. Holenz, J. Malmquist, B. Swahn, 2013, Drug Metabolism and Disposition.

BIOMIMETIC TOTAL SYNTHESIS OF MICHELLAMINES A-C

J. Holenz, G. Bringmann, S. Harmsen, 1996 .