Á. Valverde

Á. Valverde, J. G. García Fernández, C. O. Mellet, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain.

Á. Valverde, E. Rozengurt, J. Sinnett-Smith, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection.

Á. Valverde, J. Muntané, Á. González-Rodríguez, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

p38α deficiency restrains liver regeneration after partial hepatectomy triggering oxidative stress and liver injury

P. Rada, Á. Valverde, J. Sastre, 2019, Scientific Reports.

Eukaryotic Elongation Factor 2 Controls Tnf-alpha Translation in Lps-induced Hepatitis Recommended Citation Eukaryotic Elongation Factor 2 Controls Tnf-alpha Translation in Lps- Induced Hepatitis Eukaryotic Elongation Factor 2 Controls Tnf-α Translation in Lps-induced Hepatitis

Pilar Martín, Á. Valverde, Roger J. Davis, 2022 .

Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis.

Pilar Martín, Á. Valverde, Roger J. Davis, 2013, The Journal of clinical investigation.

Increased Hypothalamic Anti-Inflammatory Mediators in Non-Diabetic Insulin Receptor Substrate 2-Deficient Mice

Á. Valverde, M. Vinaixa, V. Barrios, 2021, Cells.

A (1)H NMR metabolic profiling to the assessment of protein tyrosine phosphatase 1B role in liver regeneration after partial hepatectomy.

X. Correig, Á. Valverde, M. Vinaixa, 2013, Biochimie.

Signalling pathways involved in paracetamol-induced hepatotoxicity: new insights on the role of protein tyrosine phosphatase 1B

Á. Valverde, M. Mobasher, 2014, Archives of physiology and biochemistry.

Insulin directly stimulates VEGF-A production in the glomerular podocyte.

Á. Valverde, M. Saleem, P. Mathieson, 2013, American journal of physiology. Renal physiology.

Glycogen storage in the human retinal pigment epithelium: a comparative study of diabetic and non-diabetic donors

Á. Valverde, R. Simó, J. Guinovart, 2014, Acta Diabetologica.

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

Á. Valverde, J. Muntané, G. Fimia, 2014, Cell Death and Disease.

Insights Into Extracellular Vesicles as Biomarker of NAFLD Pathogenesis

P. Rada, Á. Valverde, R. Alén, 2020, Frontiers in Medicine.

CHOP is a critical regulator of acetaminophen-induced hepatotoxicity.

Takao Iwawaki, Viviana Scaiewicz, R. Xavier, 2013, Journal of hepatology.

Involvement of G protein-coupled receptor kinase 2 (GRK2) in the development of non-alcoholic steatosis and steatohepatitis in mice and humans.

P. Rada, Á. Valverde, Cristina Sánchez-González, 2018, Biochimica et biophysica acta. Molecular basis of disease.

Inhibition of caspases rescues brown adipocytes from apoptosis downregulating BCL-XS and upregulating BCL-2 gene expression.

M. Benito, Á. Valverde, P. Navarro, 1999, Experimental cell research.

Transforming growth factor β1 induces mitogenesis in fetal rat brown adipocytes

M. Benito, Á. Valverde, M. Lorenzo, 1996 .

Transforming growth factorβ 1 induces differentiation‐specific gene expression in fetal rat brown adipocytes

M. Benito, Á. Valverde, M. Lorenzo, 1995 .

Protein-tyrosine Phosphatase 1B (PTP1B) Deficiency Confers Resistance to Transforming Growth Factor-β (TGF-β)-induced Suppressor Effects in Hepatocytes*

Á. Valverde, Á. González-Rodríguez, I. Fabregat, 2012, The Journal of Biological Chemistry.

Malic enzyme and glucose 6-phosphate dehydrogenase gene expression increases in rat liver cirrhogenesis.

M. Benito, Á. Valverde, M. Lorenzo, 1997, British Journal of Cancer.

Proapoptotic and survival signaling in the neuroretina at early stages of diabetic retinopathy

Á. Valverde, R. Simó, Á. González-Rodríguez, 2013, Molecular vision.

Inflammation and Inflammatory Mediators in Kidney Disease Inhibition of T-cell activation by the CTLA 4-Fc Abatacept is sufficient to ameliorate proteinuric kidney disease

Á. Valverde, A. Sabirsh, L. Jermutus, 2017 .

IGF-1, Inflammation and Retinal Degeneration: A Close Network

Á. Valverde, A. Campos-Caro, A. Arroba, 2018, Front. Aging Neurosci..

Tumor Necrosis Factor-α Causes Insulin Receptor Substrate-2-Mediated Insulin Resistance and Inhibits Insulin-Induced Adipogenesis in Fetal Brown Adipocytes.

M. Benito, Á. Valverde, P. Navarro, 1998, Endocrinology.

Effects of the neuroprotective drugs somatostatin and brimonidine on retinal cell models of diabetic retinopathy

Á. Valverde, R. Simó, M. Porta, 2016, Acta Diabetologica.

Activated Ha-ras Induces Apoptosis by Association with Phosphorylated Bcl-2 in a Mitogen-activated Protein Kinase-independent Manner*

M. Benito, Á. Valverde, M. Lorenzo, 1999, The Journal of Biological Chemistry.

Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro

B. Viollet, Á. Valverde, A. Calle-Pascual, 2021, Redox biology.

Inhibition of PTP1B Restores IRS1-Mediated Hepatic Insulin Signaling in IRS2-Deficient Mice

Á. Valverde, Á. González-Rodríguez, D. Burks, 2009, Diabetes.

Insulin produces myogenesis in C2C12 myoblasts by induction of NF‐κB and downregulation of AP‐1 activities

M. Benito, Á. Valverde, M. Lorenzo, 2001, Journal of cellular physiology.

Tumor necrosis factor-alpha causes insulin receptor substrate-2-mediated insulin resistance and inhibits insulin-induced adipogenesis in fetal brown adipocytes.

M. Benito, Á. Valverde, P. Navarro, 1998, Endocrinology.

Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes.

Á. Valverde, D. Serra, M. Obregon, 2016, Biochimica et biophysica acta.

Insulin-like growth factor I and insulin induce adipogenic-related gene expression in fetal brown adipocyte primary cultures.

M. Benito, Á. Valverde, M. Lorenzo, 1996, The Biochemical journal.

Okadaic acid inhibits insulin‐induced glucose transport in fetal brown adipocytes in an Akt‐independent and protein kinase C ζ‐dependent manner

M. Benito, Á. Valverde, C. Mur, 2000, FEBS letters.

IGF-I is a mitogen involved in differentiation-related gene expression in fetal rat brown adipocytes

M. Benito, Á. Valverde, M. Lorenzo, 1993, The Journal of cell biology.

Proliferation of fetal brown adipocyte primary cultures: relationship with the genetic expression of glucose 6 phosphate dehydrogenase.

M. Benito, Á. Valverde, M. Lorenzo, 1991, Experimental cell research.

H-ras induces glucose uptake in brown adipocytes in an insulin- and phosphatidylinositol 3-kinase-independent manner.

M. Benito, Á. Valverde, P. Navarro, 1998, Experimental cell research.

Differentiation of rat brown adipocytes during late foetal development: role of insulin-like growth factor I.

M. Benito, Á. Valverde, A. Álvarez, 1995, The Biochemical journal.

Insulin receptor substrate (IRS) proteins IRS-1 and IRS-2 differential signaling in the insulin/insulin-like growth factor-I pathways in fetal brown adipocytes.

M. Benito, Á. Valverde, M. White, 1998, Molecular endocrinology.

Alterations in the insulin signaling pathway induced by immortalization and H-ras transformation of brown adipocytes.

M. Benito, Á. Valverde, M. Lorenzo, 1997, Endocrinology.

Role of IRS-3 in the Insulin Signaling of IRS-1-deficient Brown Adipocytes*

M. Benito, Á. Valverde, M. Arribas, 2003, Journal of Biological Chemistry.

Inhibition of PI 3‐kinase and RAS blocks IGF‐I and insulin‐induced uncoupling protein 1 gene expression in brown adipocytes

M. Benito, Á. Valverde, P. Navarro, 1998, Journal of cellular physiology.

Phosphatidylinositol 3-kinase is a requirement for insulin-like growth factor I-induced differentiation, but not for mitogenesis, in fetal brown adipocytes.

M. Benito, Á. Valverde, P. Navarro, 1997, Molecular endocrinology.

Protein tyrosine phosphatase deficiency protects against the induction of the early apoptosis by paracetamol in hepatocytes

Á. Valverde, M. Mobasher, 2014 .

Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice.

Á. Valverde, D. Francés, C. Carnovale, 2016, Biochimica et biophysica acta.

Cyclooxygenase‐2 over‐expression inhibits liver apoptosis induced by hyperglycemia

Á. Valverde, D. Francés, C. Carnovale, 2013, Journal of cellular biochemistry.

Protein-tyrosine Phosphatases Are Involved in Interferon Resistance Associated with Insulin Resistance in HepG2 Cells and Obese Mice*

Á. Valverde, J. Solís-Herruzo, M. T. Muñoz-Yagüe, 2012, The Journal of Biological Chemistry.

Essential role of protein kinase Cζ in the impairment of insulin‐induced glucose transport in IRS‐2‐deficient brown adipocytes

J. Klein, M. Benito, Á. Valverde, 2003, FEBS letters.

A novel glucagon‐like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice

M. Bednarek, Á. Valverde, Á. González-Rodríguez, 2017, Hepatology.

PTP1B deficiency enhances liver growth during suckling by increasing the expression of insulin‐like growth factor‐I

Á. Valverde, Á. González-Rodríguez, C. Rondinone, 2010, Journal of cellular physiology.

Hormonal regulation of malic enzyme and glucose-6-phosphate-dehydrogenase expression in fetal brown-adipocyte primary cultures under non-proliferative conditions.

M. Benito, Á. Valverde, M. Lorenzo, 1992, European journal of biochemistry.

Hepatic Cyclooxygenase-2 Expression Protects Against Diet-Induced Steatosis, Obesity, and Insulin Resistance

Á. Valverde, D. Francés, C. Carnovale, 2014, Diabetes.

Ptpn1 deletion protects oval cells against lipoapoptosis by favoring lipid droplet formation and dynamics.

M. Moreno-Aliaga, J. Balsinde, P. Rada, 2022, Cell death and differentiation.

Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis

M. Moreno-Aliaga, P. Rada, Á. Valverde, 2017, Molecular metabolism.

Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide.

M. Benito, J. Rohn, Á. Valverde, 2000, Growth Hormone & IGF Research.

IL‐6 cooperates with peroxisome proliferator‐activated receptor‐α‐ligands to induce liver fatty acid binding protein (LFABP) up‐regulation

Á. Valverde, Á. González-Rodríguez, F. Pavón, 2013, Liver international : official journal of the International Association for the Study of the Liver.

IRS-3 mediates insulin-induced glucose uptake in differentiated IRS-2−/− brown adipocytes

M. Benito, Á. Valverde, Ó. Escribano, 2007, Molecular and Cellular Endocrinology.

Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes.

M. Moreno-Aliaga, Á. Valverde, A. Cuadrado, 2015, Free radical biology & medicine.

Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury

P. Rada, Á. Valverde, Á. González-Rodríguez, 2019, Disease Models & Mechanisms.

Studies of naturally occurring friedelane triterpenoids as insulin sensitizers in the treatment type 2 diabetes mellitus.

Á. Valverde, Á. González-Rodríguez, V. Pardo, 2012, Phytochemistry.

S6K1 deficiency protects against apoptosis in hepatocytes

Á. Valverde, Á. González-Rodríguez, Javier Alba, 2009, Hepatology.

Somatostatin protects human retinal pericytes from inflammation mediated by microglia

Á. Valverde, M. Porta, A. Arroba, 2017, Experimental eye research.

Differential mitogenic signaling in insulin receptor-deficient fetal pancreatic beta-cells.

M. Benito, Á. Valverde, P. Navarro, 2006, Endocrinology.

Normal Proliferation and Tumorigenesis but Impaired Pancreatic Function in Mice Lacking the Cell Cycle Regulator Sei1

Á. Valverde, M. Serrano, J. Flores, 2010, PloS one.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Inhibition of T-cell activation by the CTLA4-Fc Abatacept is sufficient to ameliorate proteinuric kidney disease.

Á. Valverde, A. Sabirsh, L. Jermutus, 2017, American journal of physiology. Renal physiology.

Lack of EGFR catalytic activity in hepatocytes improves liver regeneration following DDC‐induced cholestatic injury by promoting a pro‐restorative inflammatory response

Á. Valverde, C. Guerra, P. Bragado, 2022, The Journal of pathology.

Metabolic impact of partial hepatectomy in the non-alcoholic steatohepatitis animal model of methionine-choline deficient diet.

Á. Valverde, Joanna Godzien, S. Angulo, 2019, Journal of pharmaceutical and biomedical analysis.

Nuclear forkhead box O1 controls and integrates key signaling pathways in hepatocytes.

E. Van Obberghen, D. Accili, Á. Valverde, 2007, Endocrinology.

Effect of Topical Administration of Somatostatin on Retinal Inflammation and Neurodegeneration in an Experimental Model of Diabetes

Á. Valverde, R. Simó, C. Hernández, 2020, Journal of clinical medicine.

Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis.

M. Benito, Á. Valverde, C. Kahn, 1999, Diabetes.

Dissecting the role of epidermal growth factor receptor catalytic activity during liver regeneration and hepatocarcinogenesis

Á. Valverde, J. Segovia, Á. González-Rodríguez, 2016, Hepatology.

Role of insulin receptor in the regulation of glucose uptake in neonatal hepatocytes.

M. Benito, Á. Valverde, C. Nevado, 2006, Endocrinology.

Attenuation of Olanzapine-Induced Endoplasmic Reticulum Stress Improves Insulin Secretion in Pancreatic Beta Cells

Á. Valverde, R. Alén, Diana Grajales, 2022, Metabolites.

Involvement of Raf-1 kinase and protein kinase C zeta in insulin-like growth factor I-induced brown adipocyte mitogenic signaling cascades: inhibition by cyclic adenosine 3',5'-monophosphate.

M. Benito, Á. Valverde, M. Lorenzo, 1996, Endocrinology.

p21ras induced differentiation-related gene expression in fetal brown adipocyte primary cells and cell lines.

M. Benito, Á. Valverde, A. Álvarez, 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

cAMP inhibits IGF-I-induced mitogenesis in fetal rat brown adipocytes: role of p21 ras.

M. Benito, Á. Valverde, M. Lorenzo, 1995, Experimental cell research.

Epidermal growth factor impairs the cytochrome C/caspase-3 apoptotic pathway induced by transforming growth factor beta in rat fetal hepatocytes via a phosphoinositide 3-kinase-dependent pathway.

M. Benito, Á. Valverde, I. Fabregat, 2000, Hepatology.

Second-Generation Antipsychotics and Dysregulation of Glucose Metabolism: Beyond Weight Gain

Á. Valverde, Vítor Ferreira, Diana Grajales, 2019, Cells.

Friedelane-type triterpenoids as selective anti-inflammatory agents by regulation of differential signaling pathways in LPS-stimulated macrophages.

Á. Valverde, Á. González-Rodríguez, E. López-Collazo, 2016, Toxicology and applied pharmacology.

Correction to “Aripiprazole Cytotoxicity Coincides with Activation of the Unfolded Protein Response in Human Hepatic Cells”

P. Rada, Á. Valverde, B. Tirosh, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Aripiprazole Cytotoxicity Coincides with Activation of the Unfolded Protein Response in Human Hepatic Cells

P. Rada, Á. Valverde, B. Tirosh, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Anti-Inflammatory (M2) Response Is Induced by a sp2-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy

Á. Valverde, A. Campos-Caro, C. Ortiz Mellet, 2021, Frontiers in Immunology.

Inhibition of Protein Tyrosine Phosphatase 1B Improves IGF-I Receptor Signaling and Protects Against Inflammation-Induced Gliosis in the Retina.

Á. Valverde, A. Arroba, 2015, Investigative ophthalmology & visual science.

Beneficial effects of fenofibrate in retinal pigment epithelium by the modulation of stress and survival signaling under diabetic conditions

Á. Valverde, R. Simó, Á. González-Rodríguez, 2012, Journal of cellular physiology.

Topical Administration of GLP-1 Receptor Agonists Prevents Retinal Neurodegeneration in Experimental Diabetes

J. A. Arranz, Á. Valverde, R. Simó, 2015, Diabetes.

Initial expression of phosphoenolpyruvate carboxykinase gene in fetal hepatocytes: role of transcription factors.

M. Benito, Á. Valverde, M. Lorenzo, 1996, Journal of hepatology.

Susceptibility to apoptosis in insulin-like growth factor-I receptor-deficient brown adipocytes.

M. Benito, Á. Valverde, M. Brownlee, 2004, Molecular biology of the cell.

Epidermal Growth Factor Impairs the Cytochrome C/Caspase‐3 Apoptotic Pathway Induced by Transforming Growth Factor β in Rat Fetal Hepatocytes Via a Phosphoinositide 3‐Kinase–Dependent Pathway

M. Benito, Á. Valverde, I. Fabregat, 2000 .

Adipose tissue as a target for second-generation (atypical) antipsychotics: A molecular view.

Á. Valverde, Vítor Ferreira, Diana Grajales, 2020, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Pten positively regulates brown adipose function, energy expenditure, and longevity.

A. Efeyan, Á. Valverde, F. Mulero, 2012, Cell metabolism.

Beneficial effects of PTP1B deficiency on brown adipocyte differentiation and protection against apoptosis induced by pro- and anti-inflammatory stimuli.

Á. Valverde, Á. González-Rodríguez, C. Rondinone, 2010, Cellular signalling.

Transforming growth factor-beta activates both pro-apoptotic and survival signals in fetal rat hepatocytes.

M. Benito, Á. Valverde, I. Fabregat, 2004, Experimental cell research.

Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases

P. Rada, Á. Valverde, V. Pardo, 2019, Redox biology.

Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice

Á. Valverde, F. Reimann, F. Gribble, 2020, Molecular metabolism.

Role of insulin receptor and the balance in the insulin receptor isoforms A and B in the regulation of apoptosis in SV 40-immortalized neonatal hepatocytes

M. Benito, Á. Valverde, C. Nevado, 2007 .

Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity

P. Rada, Á. Valverde, A. Cuadrado, 2013, Cell Death and Disease.

SIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress.

P. Rada, Á. Valverde, J. Muntané, 2017, Antioxidants & redox signaling.

SIRT 1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress

P. Rada, Á. Valverde, J. Muntané, 2018 .

Carnitine Palmitoyltransferase 1 Increases Lipolysis, UCP1 Protein Expression and Mitochondrial Activity in Brown Adipocytes

Á. Valverde, D. Serra, A. Zorzano, 2016, PloS one.

Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state

Á. Valverde, J. Zapata, J. Satrústegui, 2015, Oncotarget.

Essential role of protein tyrosine phosphatase 1B in obesity‐induced inflammation and peripheral insulin resistance during aging

Á. Valverde, Á. González-Rodríguez, C. Rondinone, 2012, Aging cell.

Cellular Models for the Study of Type 2 Diabetes

M. Benito, Á. Valverde, M. Lorenzo, 2005 .

Moderate SIRT1 overexpression protects against brown adipose tissue inflammation

Á. Valverde, D. Serra, M. Obregon, 2020, Molecular Metabolism.

Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.

M. Benito, C. Kahn, Á. Valverde, 2001, The Journal of clinical investigation.

Role of Protein Tyrosine Phosphatase 1B in Hepatocyte-Specific Insulin and Growth Factor Signaling

Á. Valverde, Á. González-Rodríguez, 2013 .

Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton.

Á. Valverde, E. Rozengurt, J. Sinnett-Smith, 1993, The Journal of biological chemistry.

Protein kinase D (PKD): a novel target for diacylglycerol and phorbol esters.

Á. Valverde, E. Rozengurt, J. Sinnett-Smith, 1995, Mutation research.

Single administration of recombinant IL‐6 restores the gene expression of lipogenic enzymes in liver of fasting IL‐6‐deficient mice

Á. Valverde, F. Pavón, J. Suárez, 2016, British journal of pharmacology.

Imbalance between pro‐apoptotic and pro‐survival factors in human retinal pericytes in diabetic‐like conditions

Á. Valverde, M. Porta, A. Arroba, 2018, Acta ophthalmologica.

Differential insulin receptor substrate-1 (IRS1)-related modulation of neuropeptide Y and proopiomelanocortin expression in nondiabetic and diabetic IRS2-/- mice.

Á. Valverde, G. Frühbeck, J. Argente, 2012, Endocrinology.

Effects of a Mealworm (Tenebrio molitor) Extract on Metabolic Syndrome-Related Pathologies: In Vitro Insulin Sensitivity, Inflammatory Response, Hypolipidemic Activity and Oxidative Stress

P. Rada, Á. Valverde, M. Monsalve, 2022, Insects.

Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease

T. Quesada-López, F. Villarroya, W. Wahli, 2017, Molecular metabolism.

Moderate SIRT1 overexpression protects against inflammation of brown adipose tissue.

Á. Valverde, D. Serra, M. Obregon, 2020, Molecular metabolism.

Protein–Tyrosine Phosphatase 1B–Deficient Myocytes Show Increased Insulin Sensitivity and Protection Against Tumor Necrosis Factor-α–Induced Insulin Resistance

Á. Valverde, C. Rondinone, M. Lorenzo, 2007, Diabetes.

The brown adipose cell: a unique model for understanding the molecular mechanism of insulin resistance.

M. Benito, Á. Valverde, 2005, Mini reviews in medicinal chemistry.

Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight.

P. Rada, Á. Valverde, F. Abad‐Santos, 2022, Metabolism: clinical and experimental.

The brown adipose cell: a model for understanding the molecular mechanisms of insulin resistance.

M. Benito, Á. Valverde, M. Lorenzo, 2005, Acta physiologica Scandinavica.

Increased FGF21 in brown adipose tissue of tyrosine hydroxylase heterozygous mice: implications for cold adaptation[S]

J. Balsinde, Á. Valverde, Miguel López, 2018, Journal of Lipid Research.

Opposite Cross-Talk by Oleate and Palmitate on Insulin Signaling in Hepatocytes through Macrophage Activation*

J. Balsinde, Á. Valverde, Á. González-Rodríguez, 2015, The Journal of Biological Chemistry.

New therapeutic targets for the treatment of insulin resistance based on the paracrine cross-talk between hepatocytes and Kupffer cells

Á. Valverde, Á. González-Rodríguez, P. Marqués, 2016 .

In vivo siRNA delivery of Keap1 modulates death and survival signaling pathways and attenuates concanavalin-A-induced acute liver injury in mice

Á. Valverde, Á. González-Rodríguez, C. Rondinone, 2014, Disease Models & Mechanisms.

Differential Effects of a Glucagon-Like Peptide 1 Receptor Agonist in Non-Alcoholic Fatty Liver Disease and in Response to Hepatectomy

Á. Valverde, C. Rondinone, C. Barbas, 2018, Scientific Reports.

Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C.

Á. Valverde, Á. González-Rodríguez, L. Boscá, 2011, Journal of hepatology.

Protection against gamma-radiation injury by protein tyrosine phosphatase 1B

P. Rada, Á. Valverde, L. Boscá, 2018, Redox biology.

Pivotal role of protein tyrosine phosphatase 1B (PTP1B) in the macrophage response to pro-inflammatory and anti-inflammatory challenge

Á. Valverde, Á. González-Rodríguez, L. Boscá, 2014, Cell Death and Disease.

Modulation of microglia in the retina: new insights into diabetic retinopathy

Á. Valverde, A. Arroba, 2017, Acta Diabetologica.

Protein Tyrosine Phosphatase 1B (PTP1B) deficiency accelerates hepatic regeneration in mice.

Á. Valverde, Á. González-Rodríguez, Margarita Fernández, 2011, The American journal of pathology.

Topical Administration of Somatostatin Prevents Retinal Neurodegeneration in Experimental Diabetes

Á. Valverde, R. Simó, Á. González-Rodríguez, 2013, Diabetes.

Modulation of microglia polarization dynamics during diabetic retinopathy in db/db mice.

Á. Valverde, R. Simó, C. Hernández, 2016, Biochimica et biophysica acta.

Defective liver glycogen autophagy related to hyperinsulinemia in intrauterine growth-restricted newborn wistar rats

Á. Valverde, Á. González-Rodríguez, E. Fernández-Millán, 2020, Scientific Reports.

Somatostatin protects photoreceptor cells against high glucose – induced apoptosis

Á. Valverde, R. Simó, M. Porta, 2016 .

Saturated fatty acid-enriched small extracellular vesicles mediate a crosstalk inducing liver inflammation and hepatocyte insulin resistance

Á. Valverde, L. Boscá, E. López-Collazo, 2023, JHEP reports : innovation in hepatology.

Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.

M. Benito, Á. Valverde, Á. González-Rodríguez, 2007, Endocrinology.

A positive feedback loop between AMPK and GDF15 promotes metformin antidiabetic effects.

W. Wahli, P. Rada, Á. Valverde, 2022, Pharmacological research.

PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes.

M. Benito, Á. Valverde, G. Sesti, 2008, American journal of physiology. Gastrointestinal and liver physiology.

Abbreviated title: Glucose uptake in PTP1B -/- neonatal hepatocytes

A. Sols, M. Benito, Á. Valverde, 2008 .

PTP 1 B deficiency increases glucose uptake in neonatal hepatocytes : involvement of IRA / GLUT 2 complexes

M. Benito, Á. Valverde, G. Sesti, 2008 .

Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner.

P. Rada, Á. Valverde, A. Cuadrado, 2015, Molecular nutrition & food research.

SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function

Á. Valverde, M. Serrano, P. García-Rovés, 2014, Molecular metabolism.

Essential Role of Protein-tyrosine Phosphatase 1B in the Modulation of Insulin Signaling by Acetaminophen in Hepatocytes*

Á. Valverde, J. Muntané, Á. González-Rodríguez, 2014, The Journal of Biological Chemistry.

Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1.

J. Gisbert, Á. Valverde, Á. González-Rodríguez, 2013, Toxicology and applied pharmacology.

Aging in male Wistar rats associates with changes in intestinal microbiota, gut structure and cholecystokinin-mediated gut-brain axis function.

Á. Valverde, C. Álvarez, L. Guijarro, 2020, The journals of gerontology. Series A, Biological sciences and medical sciences.

p38α deficiency restrains liver regeneration after partial hepatectomy triggering oxidative stress and liver injury

P. Rada, Á. Valverde, J. Sastre, 2019, Scientific Reports.

p21Cip1 plays a critical role in the physiological adaptation to fasting through activation of PPARα

Á. Valverde, M. Serrano, G. Gómez-López, 2016, Scientific Reports.

RNA Interference as a Therapeutic Strategy for the Treatment of Liver Diseases.

Á. Valverde, Á. González-Rodríguez, 2015, Current pharmaceutical design.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

Effects of the second-generation antipsychotic drugs aripiprazole and olanzapine on human adipocyte differentiation

Á. Valverde, Jenny Casey Eriksson, Vítor Ferreira, 2022, Molecular and Cellular Endocrinology.

Insulin Receptor Substrate 2 (IRS2)-Deficient Mice Show Sensorineural Hearing Loss That Is Delayed by Concomitant Protein Tyrosine Phosphatase 1B (PTP1B) Loss of Function

Á. Valverde, C. Avendaño, Á. González-Rodríguez, 2012, Molecular medicine.

Phosphoenolpyruvate carboxykinase and glucose-6-phosphate dehydrogenase expression in fetal hepatocyte primary cultures under proliferative conditions.

M. Benito, Á. Valverde, M. Lorenzo, 1992, Experimental cell research.

Maresin 1 activates brown adipose tissue and promotes browning of white adipose tissue in mice

M. Moreno-Aliaga, T. Quesada-López, F. Villarroya, 2023, Molecular metabolism.

Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via intraperitoneal: Additional effects of PTP1B inhibition

J. Cigudosa, P. Rada, Á. Valverde, 2023, Redox biology.

Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.

M. Benito, C. Kahn, Á. Valverde, 2019, The Journal of clinical investigation.

Enhanced Wild-Type MET Receptor Levels in Mouse Hepatocytes Attenuates Insulin-Mediated Signaling

P. Rada, Á. Valverde, F. Maina, 2022, Cells.

Role of insulin receptor and balance in insulin receptor isoforms A and B in regulation of apoptosis in simian virus 40-immortalized neonatal hepatocytes.

M. Benito, Á. Valverde, C. Nevado, 2007, Molecular biology of the cell.

The protective role of peroxisome proliferator-activated receptor gamma in lipotoxic podocytes.

Á. Valverde, G. Medina-Gómez, Almudena G Carrasco, 2023, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Protective effects of the succinate/SUCNR1 axis on damaged hepatocytes in NAFLD.

P. Rada, Á. Valverde, J. Moreno-Navarrete, 2023, Metabolism: clinical and experimental.

Bombesin Stimulation of p 125 Focal Adhesion Kinase Tyrosine Phosphorylation

Á. Valverde, J. Sinnett-Smith, I. Zachary, 2001 .

Loss of protein tyrosine phosphatase 1B increases IGF-I receptor tyrosine phosphorylation but does not rescue retinal defects in IRS2-deficient mice.

Á. Valverde, Á. González-Rodríguez, D. Burks, 2013, Investigative ophthalmology & visual science.

Insulin and insulin-like growth factor I up-regulate GLUT4 gene expression in fetal brown adipocytes, in a phosphoinositide 3-kinase-dependent manner.

M. Benito, Á. Valverde, P. Navarro, 1999, The Biochemical journal.

Insulin/IGF-I rescues immortalized brown adipocytes from apoptosis down-regulating Bcl-xS expression, in a PI 3-kinase- and map kinase-dependent manner.

M. Benito, Á. Valverde, P. Navarro, 1998, Experimental cell research.

Insulin Receptor Substrate 2 (IRS2)-Deficient Mice Show Sensorineural Hearing Loss That Is Delayed by Concomitant Protein Tyrosine Phosphatase 1B (PTP1B) Loss of Function

Á. Valverde, C. Avendaño, Á. González-Rodríguez, 2012, Molecular medicine.

IRS2 and PTP1B: Two opposite modulators of hepatic insulin signalling

Á. Valverde, Á. González-Rodríguez, 2011, Archives of physiology and biochemistry.

"MiR-7 controls cholesterol biosynthesis through posttranscriptional regulation of DHCR24 expression".

D. Gómez-Coronado, P. Rada, Á. Valverde, 2023, Biochimica et biophysica acta. Gene regulatory mechanisms.

Association of Insulin Receptor Substrate 1 (IRS-1) Y895 with Grb-2 Mediates the Insulin Signaling Involved in IRS-1-Deficient Brown Adipocyte Mitogenesis

M. Benito, C. Kahn, Á. Valverde, 2001, Molecular and Cellular Biology.

p38γ/δ MAPKs control TNFα translation in acute hepatitis

Pilar Martín, Á. Valverde, Á. González-Rodríguez, 2012 .

Insulin Receptor Substrate 2 ( IRS 2 )-Deficient Mice Show Sensorineural Hearing Loss That Is Delayed by Concomitant Protein Tyrosine Phosphatase 1 B ( PTP 1 B ) Loss of Function

Á. Valverde, Á. González-Rodríguez, G. Camarero, 2012 .

Pten positively regulates brown adipose function, energy expenditure, and longevity.

A. Efeyan, Á. Valverde, F. Mulero, 2012, Cell metabolism.

Signalling pathways involved in paracetamol-induced hepatotoxicity: new insights on the role of protein tyrosine phosphatase 1B

Á. Valverde, M. Mobasher, 2014, Archives of physiology and biochemistry.

Sterile Inflammation in Acetaminophen-induced Liver Injury Is Mediated by Cot/tpl2*

J. Velasco-Martín, Á. Valverde, J. Regadera, 2013, The Journal of Biological Chemistry.

IGF-I is a mitogen involved in differentiation-related gene expression in fetal rat brown adipocytes

M. Benito, Á. Valverde, M. Lorenzo, 1993, The Journal of cell biology.

In vivo siRNA delivery of Keap1 modulates death and survival signaling pathways and attenuates concanavalin-A-induced acute liver injury in mice

Á. Valverde, Á. González-Rodríguez, C. Rondinone, 2014, Disease Models & Mechanisms.

Differential effects of metformin glycinate and hydrochloride in glucose production, AMPK phosphorylation and insulin sensitivity in hepatocytes from non-diabetic and diabetic mice.

L. Rodríguez-Mañas, P. Rada, Á. Valverde, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Targeting inflammation in the retina : a new therapeutic approach in diabetic retinopathy

Á. Valverde, A. Arroba, 2017 .

The second-generation antipsychotic drug aripiprazole modulates the serotonergic system in pancreatic islets and induces beta cell dysfunction in female mice

J. Cigudosa, Á. Valverde, B. Tirosh, 2021, Diabetologia.