T. Lawrence

发表

Innate Immunity Gone Awry: Linking Microbial Infections to Chronic Inflammation and Cancer

V. Nizet, M. Karin, T. Lawrence, 2006, Cell.

IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

Toby Lawrence, Michael Karin, V. Nizet, 2005, Nature.

IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation.

Toby Lawrence, Michael Karin, V. Nizet, 2005, Nature.

Macrophage activation and polarization: nomenclature and experimental guidelines.

S. Goerdt, G. Natoli, S. Gordon, 2014, Immunity.

The nuclear factor NF-kappaB pathway in inflammation.

T. Lawrence, 2009, Cold Spring Harbor perspectives in biology.

Representing the Process of Inflammation as Key Events in Adverse Outcome Pathways.

R. Pieters, T. Lawrence, P. Allavena, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Sword and shield: linked group B streptococcal beta-hemolysin/cytolysin and carotenoid pigment function to subvert host phagocyte defense.

V. Nizet, T. Lawrence, George Y. Liu, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of NF-κB Activity by a Membrane-Transducing Mutant of IκBα1

T. Lawrence, D. Gilroy, P. Kabouridis, 2002, The Journal of Immunology.

“Re-educating” tumor-associated macrophages by targeting NF-κB

T. Lawrence, I. McNeish, T. Hagemann, 2008, The Journal of experimental medicine.

PAR-1 signaling on macrophages is required for effective in vivo delayed-type hypersensitivity responses

T. Lawrence, H. Wilkinson, J. McVey, 2021, iScience.

The Pore-Forming Toxin β hemolysin/cytolysin Triggers p38 MAPK-Dependent IL-10 Production in Macrophages and Inhibits Innate Immunity

V. Nizet, M. Hensler, J. Park, 2012, PLoS pathogens.

Lyve-1 expressing perivascular macrophages orchestrate pericyte expansion to sustain angiogenesis in cancer

S. Pinder, T. Lawrence, T. Ng, 2020, bioRxiv.

Possible new role for NF-kappaB in the resolution of inflammation.

T. Lawrence, D. Gilroy, P. Colville-Nash, 2001, Nature medicine.

Homeostatic NF-κB Signaling in Steady-State Migratory Dendritic Cells Regulates Immune Homeostasis and Tolerance.

T. Lawrence, Julien Maurizio, O. Demaria, 2015, Immunity.

Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression.

M. Turner, T. Lawrence, M. Bébien, 2019, Cell metabolism.

GADD45β Loss Ablates Innate Immunosuppression in Cancer.

T. Lawrence, C. Recordati, A. Sica, 2017, Cancer research.

Tumor-Induced Cholesterol Efflux from Macrophages Drives IL-4 Mediated Reprogramming and Tumor Progression

M. Turner, T. Lawrence, M. Bébien, 2018 .

Inflammation and cancer: a double-edged sword.

T. Lawrence, T. Hagemann, F. Balkwill, 2007, Cancer cell.

Tracking Dynamics of Spontaneous Tumors in Mice Using Photon-Counting Computed Tomography

C. Morel, T. Lawrence, Y. Boursier, 2019, iScience.

Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer

T. Lawrence, S. A. van de Pavert, P. Pudlo, 2020, Nature Communications.

High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.

Kimberly R. McDaniels, L. Touqui, T. Lawrence, 2017, Cell metabolism.

Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase &bgr;, and Not Via CD40 and I&kgr;B Kinase &agr;

L. Boon, T. Lawrence, H. Noels, 2015, Arteriosclerosis, thrombosis, and vascular biology.

Correction: Cigarette Smoke Induced Airway Inflammation Is Independent of NF-κB Signalling

Christopher S. Stevenson, I. Adcock, T. Lawrence, 2013, PLoS ONE.

Allergen-induced peribronchial fibrosis and mucus production mediated by IκB kinase β-dependent genes in airway epithelium

M. Karin, T. Lawrence, D. Broide, 2005 .

The Nuclear Factor NF- k B Pathway in Inﬂammation

T. Lawrence, 2009 .

The Nuclear Factor NF-kB Pathway in Inflammation

T. Lawrence, 2009 .

Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium.

M. Karin, T. Lawrence, D. Broide, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Implications for CSF Blockade in Profiles and Transcription Factor Activities : Phenotypes Display Differences in Cytokine Macrophage CSF-Dependent Macrophage Colony-Stimulating Factor ( CSF ) and Granulocyte-Macrophage and

T. Lawrence, J. Hamilton, A. Fleetwood, 2007 .

An Arp2/3-cPLA 2-NFκB Axis Acts as a Cell Shape Sensor to Drive Homeostatic Migration of Dendritic Cells

T. Lawrence, B. Albaud, N. Manel, 2022, SSRN Electronic Journal.

Mechanical Stimulation Shapes the Immunoregulatory Properties of Dendritic Cells

T. Lawrence, B. Albaud, N. Manel, 2022 .

CD4 T cell- intrinsic STING signaling controls the differentiation and effector functions of T H 1 and T H 9 cells

T. Lawrence, B. Ryffel, R. Flavell, 2022 .

The emerging roles of interstitial macrophages in pulmonary fibrosis: A perspective from scRNA-seq analyses

T. Lawrence, Yinming Liang, B. Yahaya, 2022, Frontiers in Immunology.

IKKalpha in the regulation of inflammation and adaptive immunity.

T. Lawrence, M. Bébien, 2007, Biochemical Society transactions.

“ Re-educating ” tumor-associated macrophages by targeting NF- (cid:3) B

T. Lawrence, I. McNeish, T. Hagemann, 2008 .

An inducible model for specific neutrophil depletion by diphtheria toxin in mice

T. Lawrence, Binhui Zhou, Yinming Liang, 2021, Science China Life Sciences.

Perivascular macrophages collaborate to facilitate chemotherapy resistance in cancer

F. Watt, T. Lawrence, C. Gillett, 2022, bioRxiv.

A novel ZsGreen knock‐in melanoma cell line reveals the function of CD11b in tumor phagocytosis

T. Lawrence, Yinming Liang, Liaoxun Lu, 2022, Immunology and cell biology.

Meningeal macrophages protect against viral neuroinfection.

F. Ginhoux, T. Lawrence, B. Malissen, 2022, Immunity.

Receptor Activator of NF-κB Orchestrates Activation of Antiviral Memory CD8 T Cells in the Spleen Marginal Zone

M. Bajénoff, T. Lawrence, J. Penninger, 2017, Cell reports.

IκB kinase (IKK)β, but not IKKα, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss

Georg Schett, Toby Lawrence, Erwin F. Wagner, 2005, The Journal of experimental medicine.

Autophagy in dendritic cells

T. Lawrence, G. Ghislat, 2018, Cellular & Molecular Immunology.

Correction tp Macrophage activation and polarization: Nomenclature and experimental guidelines [Immunity, 41, 2014 (14-20)]

S. Goerdt, G. Natoli, S. Gordon, 2014 .

Investigating macrophage and malignant cell interactions in vitro.

T. Lawrence, T. Hagemann, 2009, Methods in molecular biology.

Possible new role for NF-κB in the resolution of inflammation

T. Lawrence, D. Gilroy, P. Colville-Nash, 2001, Nature Medicine.

Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1

T. Lawrence, J. Tuckermann, J. Saklatvala, 2006, The Journal of experimental medicine.

The resolution of inflammation: anti-inflammatory roles for NF-kappaB.

T. Lawrence, C. Fong, 2010, The international journal of biochemistry & cell biology.

Anti-inflammatory lipid mediators and insights into the resolution of inflammation

T. Lawrence, D. Gilroy, D. Willoughby, 2002, Nature Reviews Immunology.

Inflammatory Resolution: new opportunities for drug discovery

Adriano G. Rossi, Derek W. Gilroy, Toby Lawrence, 2004, Nature Reviews Drug Discovery.

Novel biphasic role for lymphocytes revealed during resolving inflammation

M. Yaqoob, T. Lawrence, D. Gilroy, 2008, Blood.

Methods Animal maintenance , induction of inflammation human peritonitis sampling

M. Yaqoob, T. Lawrence, D. Gilroy, 2008 .

Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyΔ12–14 PGJ2

Geoff Bellingan, Derek W. Gilroy, Toby Lawrence, 2007, Proceedings of the National Academy of Sciences.

The resolution of inflammation and cancer.

T. Lawrence, J. Rodríguez-Vita, 2010, Cytokine & growth factor reviews.

Granulocyte-Macrophage Colony-Stimulating Factor (CSF) and Macrophage CSF-Dependent Macrophage Phenotypes Display Differences in Cytokine Profiles and Transcription Factor Activities: Implications for CSF Blockade in Inflammation1

T. Lawrence, J. Hamilton, A. Fleetwood, 2007, The Journal of Immunology.

Chronic inflammation: a failure of resolution?

T. Lawrence, D. Gilroy, 2006, International journal of experimental pathology.

Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer

M. Bajénoff, S. Moestrup, T. Lawrence, 2020, The Journal of experimental medicine.

Regulation of macrophage function in tumors: the multifaceted role of NF-kappaB.

T. Lawrence, A. Sica, T. Hagemann, 2009, Blood.

The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans.

George Kollias, John F Smyth, Toby Lawrence, 2009, The Journal of clinical investigation.

Reduced infiltration and increased apoptosis of leukocytes at sites of inflammation by systemic administration of a membrane-permeable IkappaBalpha repressor.

T. Lawrence, D. Gilroy, P. Kabouridis, 2004, Arthritis and rheumatism.

Transcriptional regulation of macrophage polarization: enabling diversity with identity

G. Natoli, T. Lawrence, 2011, Nature Reviews Immunology.

Coordinated Regulation of Signaling Pathways during Macrophage Activation

T. Lawrence, 2016, Microbiology spectrum.

Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming

T. Lawrence, B. Malissen, M. Dalod, 2014, The EMBO journal.

Autophagy in dendritic cells

T. Lawrence, G. Ghislat, 2018, Cellular & Molecular Immunology.

I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection

M. Bajénoff, M. Karin, T. Lawrence, 2013, The EMBO journal.

Sustained desensitization to bacterial Toll-like receptor ligands after resolutionof respiratory influenza infection

B. Lambrecht, J. Sirard, T. Lawrence, 2008, The Journal of experimental medicine.

Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes

Ning Liang, Toby Lawrence, Judith Aron-Wisnewsky, 2016, Nature Medicine.

Macrophages orchestrate the expansion of a proangiogenic perivascular niche during cancer progression

S. Pinder, T. Lawrence, T. Ng, 2021, Science advances.

TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine

Y. Saeys, T. Lawrence, B. Malissen, 2017, Nature Communications.

An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation

P. Cohen, T. Lawrence, M. Peggie, 2014, The Biochemical journal.

Tumour-Associated Macrophages

T. Lawrence, T. Hagemann, 2012, Springer New York.

Macrophages and NF-κB in cancer.

T. Lawrence, 2011, Current topics in microbiology and immunology.

Nuclear Factor-κB and Tumor-Associated Macrophages

T. Lawrence, A. Mancino, 2010, Clinical Cancer Research.

Regulation of macrophage function in tumors: the multifaceted role of NF- B

T. Lawrence, A. Sica, T. Hagemann, 2009 .

CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of TH1 and TH9 cells

T. Lawrence, B. Ryffel, R. Flavell, 2022, Journal for ImmunoTherapy of Cancer.

Tumor‐associated macrophages (TAMs) depend on ZEB1 for their cancer‐promoting roles

B. Győrffy, T. Lawrence, D. Dean, 2017, The EMBO journal.

Inflammation and cancer: a failure of resolution?

Toby Lawrence, T. Lawrence, 2007, Trends in pharmacological sciences.

NF-κB–dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity

T. Lawrence, B. Malissen, N. Attaf, 2021, Science Immunology.

The Role of Plasmacytoid Dendritic Cells in Cancers

T. Lawrence, Binhui Zhou, Yinming Liang, 2021, Frontiers in Immunology.

An inducible model for specific neutrophil depletion by diphtheria toxin in mice

T. Lawrence, Binhui Zhou, Yinming Liang, 2021, Science China Life Sciences.

An antiinflammatory role for IKKβ through the inhibition of “classical” macrophage activation

M. Karin, T. Lawrence, D. Broide, 2008, The Journal of experimental medicine.

Non-activatable mutant of inhibitor of kappa B kinase α (IKKα) exerts vascular site-specific effects on atherosclerosis in Apoe-deficient mice.

T. Lawrence, J. Bernhagen, A. Zernecke, 2019, Atherosclerosis.

Bone Marrow-Specific Knock-In of a Non-Activatable Ikkα Kinase Mutant Influences Haematopoiesis but Not Atherosclerosis in Apoe-Deficient Mice

T. Lawrence, J. Bernhagen, A. Zernecke, 2014, PloS one.

A Shape Sensing Mechanism driven by Arp2/3 and cPLA2 licenses Dendritic Cells for Migration to Lymph Nodes in Homeostasis

F. Ginhoux, T. Lawrence, B. Albaud, 2023, bioRxiv.

Role of NF-κB Activation in Macrophages

T. Lawrence, 2014 .

IKKα in the regulation of inflammation and adaptive immunity

T. Lawrence, M. Bébien, 2007 .

Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell–mediated tumor regression

S. Moestrup, T. Lawrence, M. Bosenberg, 2019, The Journal of experimental medicine.

An NF-κB/IRF1 axis programs cDC1s to drive anti-tumor immunity

T. Lawrence, B. Malissen, N. Attaf, 2020, bioRxiv.

The kinase p38α serves cell type–specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

T. Lawrence, B. Carlson, J. Arthur, 2008, Nature Immunology.

The resolution of acute inflammation: A ‘tipping point’ in the development of chronic inflammatory diseases

T. Lawrence, D. Gilroy, 2008 .

ICLE Chronic inflammation : a failure of resolution ?

T. Lawrence, D. Gilroy, 2007 .

The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation

T. Lawrence, M. Tsai, I. Yu, 2017, Nature Communications.

Targeting STAT3 and STAT5 in Tumor-Associated Immune Cells to Improve Immunotherapy

T. Lawrence, N. Auphan-Anezin, G. Verdeil, 2019, Cancers.

Precise and Rapid Validation of Candidate Gene by Allele Specific Knockout With CRISPR/Cas9 in Wild Mice

T. Lawrence, Yinming Liang, Zhongjian Zhang, 2019, Front. Genet..

Molecular dissection of plasmacytoid dendritic cell activation in vivo during a viral infection

T. Lawrence, M. Dalod, P. Pierre, 2018, The EMBO journal.

Inducible cyclooxygenase‐derived 15deoxy Δ 12‐14PGJ2 brings about acute inflammatory resolution in rat pleurisy by inducing neutrophil and macrophage apoptosis

T. Lawrence, D. Gilroy, P. Colville-Nash, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Air-pouch models of inflammation and modifications for the study of granuloma-mediated cartilage degradation.

T. Lawrence, P. Colville-Nash, 2003, Methods in molecular biology.

Soluble ectodomain CD163 and extracellular vesicle-associated CD163 are two differently regulated forms of ‘soluble CD163’ in plasma

S. Moestrup, H. Møller, T. Lawrence, 2017, Scientific Reports.

LYVE-1+ macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer.

F. Watt, T. Lawrence, J. Burchell, 2023, Developmental cell.

Sex, Cytokines, and Cancer

T. Lawrence, T. Hagemann, F. Balkwill, 2007, Science.

Cancer. Sex, cytokines, and cancer.

T. Lawrence, F. Balkwill, Thorsten Hageman, 2007, Science.

Cigarette Smoke Induced Airway Inflammation Is Independent of NF-κB Signalling

Christopher S. Stevenson, I. Adcock, T. Lawrence, 2013, PloS one.

Modulation of inflammation in vivo through induction of the heat shock response, effects on NF-κB activation

T. Lawrence, 2002, Inflammation Research.

New insights into inflammatory resolution

T. Lawrence, D. Gilroy, P. Colville-Nash, 2001, InflammoPharmacology.

The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans.

G. Kollias, T. Lawrence, P. Chakravarty, 2009, The Journal of clinical investigation.

Homeostatic NF-κB Signaling in Steady-State Migratory Dendritic Cells Regulates Immune Homeostasis and Tolerance.

T. Lawrence, Julien Maurizio, O. Demaria, 2015, Immunity.

Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes

T. Lawrence, E. Treuter, F. Foufelle, 2016, Nature Medicine.

An antiinflammatory role for IKKβ through the inhibition of “classical” macrophage activation

M. Karin, T. Lawrence, D. Broide, 2008, The Journal of experimental medicine.

“Re-educating” tumor-associated macrophages by targeting NF-κB

T. Lawrence, I. McNeish, T. Hagemann, 2008, The Journal of experimental medicine.

Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1

T. Lawrence, J. Tuckermann, J. Saklatvala, 2006, The Journal of experimental medicine.

IκB kinase (IKK)β, but not IKKα, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss

E. Wagner, M. Karin, T. Lawrence, 2005, The Journal of experimental medicine.

The three members of the Vav family proteins form complexes that concur to foam cell formation and atherosclerosis[S]

T. Lawrence, B. Malissen, M. Malissen, 2019, Journal of Lipid Research.