V. Speirs

V. Speirs, P. Carder, M. Lansdown, 2006, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

Pan-cancer image-based detection of clinically actionable genetic alterations

Jakob Nikolas Kather, T. Luedde, P. A. van den Brandt, 2019, Nature Cancer.

Prognostic and predictive value of ERβ1 and ERβ2 in the Intergroup Exemestane Study (IES)-first results from PathIES†.

P. Lønning, M. Cheang, V. Speirs, 2015, Annals of oncology : official journal of the European Society for Medical Oncology.

Phosphorylation of estrogen receptor beta at serine 105 is associated with good prognosis in breast cancer.

V. Speirs, K. Horgan, A. Shaaban, 2010, The American journal of pathology.

Gene expression signatures may predict clinical outcome

V. Speirs, 2002, Breast Cancer Research.

Expression of alternatively spliced estrogen receptor alpha mRNAs is increased in breast cancer tissues

V. Speirs, I. Poola, 2001, The Journal of Steroid Biochemistry and Molecular Biology.

Hormone receptors in defining breast cancer prognosis—time for a rethink?

V. Speirs, A. Shaaban, 2007, Nature Clinical Practice Oncology.

Oestrogen receptor β: what it means for patients with breast cancer

V. Speirs, D. Dodwell, P. Carder, 2004 .

Immunohistochemical detection of ERβ in breast cancer: towards more detailed receptor profiling?

V. Speirs, P. Carder, G. Skliris, 2001, British Journal of Cancer.

A Review of International Biobanks and Networks: Success Factors and Key Benchmarks-A 10-Year Retrospective Review.

Andrew G. Hall, A. Mes-Masson, P. Riegman, 2019, Biopreservation and biobanking.

Loss of expression of oestrogen receptor beta in colon cancer and its association with Dukes' staging.

V. Speirs, P. Quirke, S. Bell, 2005, Oncology reports.

Expression of cytokine messenger RNA in normal and neoplastic human breast tissue: Identification of interleukin‐8 as a potential regulatory factor in breast tumours

A. Green, V. Speirs, M. White, 1997, International journal of cancer.

3-D Tissue Modelling and Virtual Pathology as New Approaches to Study Ductal Carcinoma In Situ

Mary E Booth, D. Magee, D. Treanor, 2015, Alternatives to laboratory animals : ATLA.

Raman spectroscopy: current applications in breast cancer diagnosis, challenges and future prospects

V. Speirs, A. Shaaban, D. Muirhead, 2021, British Journal of Cancer.

Relationship of Extreme Chromosomal Instability with Long-term Survival in a Retrospective Analysis of Primary Breast Cancer

Nicolai J. Birkbak, Z. Szallasi, A. Eklund, 2011, Cancer Epidemiology, Biomarkers & Prevention.

Articles selected from Faculty of 1000 in September 2003

V. Speirs, 2003, Breast Cancer Research.

Articles selected from Faculty of 1000 in November 2003

V. Speirs, 2003, Breast Cancer Research.

Expression and secretion of TGF-beta isoforms and expression of TGF-beta-receptors I, II and III in normal and neoplastic human breast.

A. Green, M. Kerin, V. Speirs, 1999, International journal of oncology.

A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer

Lucy F. Stead, I. Ellis, S. Shousha, 2016, Clinical Cancer Research.

A novel cell array technique for high-throughput, cell-based analysis

V. Speirs, A. Hanby, A. Hanby, 2005, In Vitro Cellular & Developmental Biology - Animal.

Inflammatory breast cancer: time to standardise diagnosis assessment and management, and for the joining of forces to facilitate effective research

I. Ellis, D. Rea, E. Rakha, 2015, British Journal of Cancer.

Advances in the development of improved animal-free models for use in breast cancer biomedical research

V. Speirs, Sophie Roberts, 2017, Biophysical Reviews.

Distinct expression patterns of ER alpha and ER beta in normal human mammary gland.

V. Speirs, P. Carder, G. Skliris, 2002, Journal of clinical pathology.

The rising incidence of male breast cancer

V. Speirs, A. Shaaban, 2009, Breast Cancer Research and Treatment.

Choosing the right cell line for breast cancer research

Valerie Speirs, V. Speirs, Deborah L Holliday, 2011, Breast Cancer Research.

An Evaluation of Matrix-Containing and Humanised Matrix-Free 3-Dimensional Cell Culture Systems for Studying Breast Cancer

V. Speirs, Claire Nash, D. Holliday, 2016, PloS one.

Morphological Features and Immunohistochemical Profiling of Male Breast Gynaecomastia; A Large Tissue Microarray Study

V. Speirs, A. Shaaban, Prakruthi Prasad, 2022, Frontiers in Oncology.

Role of ERβ in Clinical Breast Cancer.

V. Speirs, A. Shaaban, 2009, Cancer treatment and research.

Prognostic significance of oestrogen receptor beta in breast cancer.

M. Kerin, V. Speirs, 2000, The British journal of surgery.

Coexpression of estrogen receptor alpha and beta: poor prognostic factors in human breast cancer?

M. Kerin, V. Speirs, S. Atkin, 1999, Cancer research.

Analysis of the Clinical Advancements for BRCA-Related Malignancies Highlights the Lack of Treatment Evidence for BRCA-Positive Male Breast Cancer

V. Speirs, T. McGoldrick, B. Elsberger, 2022, Cancers.

Interactive effects of interleukin-6, 17β-estradiol and progesterone on growth and 17β-hydroxysteroid dehydrogenase activity in human breast carcinoma cells

V. Speirs, B. Rafferty, M. White, 1993, The Journal of Steroid Biochemistry and Molecular Biology.

Differential response to phytoestrogens in endocrine sensitive and resistant breast cancer cells in vitro

V. Speirs, A. Parkes, J. Limer, 2006, International journal of cancer.

Review Phyto-oestrogens and breast cancer chemoprevention

V. Speirs, J. Limer, 2004 .

Advances in Brief Increased Expression of Estrogen Receptor b mRNA in Tamoxifen-resistant Breast Cancer Patients 1

M. Kerin, V. Speirs, S. Atkin, 1999 .

In vivo and in vitro expression of steroid-converting enzymes in human breast tumours: associations with interleukin-6

V. Speirs, S. Atkin, D. Walton, 1999, British Journal of Cancer.

The Molecular Pathology of Male Breast Cancer

V. Speirs, A. Hanby, T. Hughes, 2015 .

Differential expression of cell adhesion molecules in phenotypic variants of the small cell lung carcinoma cell line NCI-H69

V. Speirs, S. Atkin, V. Green, 1998, In Vitro Cellular & Developmental Biology - Animal.

Localization of MOC-1 cell surface antigen in small-cell lung carcinoma cell lines: an immunohistochemical and immunoelectron microscopic study.

V. Speirs, E. Cutz, S. Eich-Bender, 1993, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Downregulation of 15-hydroxyprostaglandin dehydrogenase during acquired tamoxifen resistance and association with poor prognosis in ERα-positive breast cancer

B. Broom, H. Brauch, V. Speirs, 2020, Exploration of targeted anti-tumor therapy.

Cell biology of pulmonary neuroepithelial bodies—validation of an in vitro model. I. Effects of hypoxia and Ca2+ ionophore on serotonin content and exocytosis of dense core vesicles

V. Speirs, H. Yeger, E. Cutz, 1993, The Anatomical record.

An overview of culture and isolation methods suitable for in vitro studies on pulmonary neuroendocrine cells

V. Speirs, E. Cutz, 1993, The Anatomical record.

Isolation and culture of neuroendocrine cells from fetal rabbit lung using immunomagnetic techniques.

V. Speirs, H. Yeger, E. Cutz, 1992, American journal of respiratory cell and molecular biology.

Estrogen Receptor β 1 Expression Is Regulated by miR-92 in Breast Cancer

V. Speirs, P. Burns, A. Shaaban, 2010 .

Integrative, In Silico and Comparative Analysis of Breast Cancer Secretome Highlights Invasive-Ductal-Carcinoma-Grade Progression Biomarkers

V. Speirs, Y. Masannat, S. Kastora, 2022, Cancers.

A comparative study of cytokine gene transcripts in normal and malignant breast tissue and primary cell cultures derived from the same tissue samples

A. Green, V. Speirs, M. White, 1996, International journal of cancer.

Oestrogen receptor beta: how should we measure this?

V. Speirs, P. Carder, M. Lansdown, 2002, British Journal of Cancer.

Paracrine effects of bombesin/gastrin‐releasing peptide and other growth factors on pulmonary neuroendocrine cells in vitro

V. Speirs, E. Cutz, V. Wong, 1993, The Anatomical record.

Promoter switch: a novel mechanism causing biallelic PEG1/MEST expression in invasive breast cancer.

V. Speirs, J. Isaacs, F. Ponchel, 2002, Human molecular genetics.

RT‐PCR DETECTION OF CYTOKINE TRANSCRIPTS IN A SERIES OF CULTURED HUMAN MENINGIOMAS

V. Speirs, M. Birch, W. Fraser, 1996, The Journal of pathology.

Interleukin-6 (IL-6) production and cell growth of cultured human ameningiomas:- Interactions with interleukin-1β (IL-1β) and interleukin-4 (IL-4) in vitro

V. Speirs, E. Boyle-Walsh, M. White, 1994, Neuroscience Letters.

Short-term primary culture of epithelial cells derived from human breast tumours.

A. Green, M. Kerin, V. Speirs, 1998, British Journal of Cancer.

Intracellular Flow Cytometric Analysis of Primary Cultured Breast Tumor Cells

P. Drew, J. Monson, M. Kerin, 2002, Cancer investigation.

Barriers to the release of human tissue for clinical trials research in the UK: a national survey of cellular pathology laboratories on behalf of the National Cancer Research Institute’s Cellular Molecular Pathology (CM-Path) initiative

Andrew G. Hall, V. Speirs, C. Verrill, 2018, Journal of Clinical Pathology.

Characterisation of male breast cancer

S. Shousha, E. Provenzano, V. Speirs, 2017 .

Investigating and critically appraising the expression and potential role of androgen receptor in breast carcinoma

V. Speirs, K. Horgan, A. Shaaban, 2011, Hormone molecular biology and clinical investigation.

A Multi-Centre Investigation Towards Reaching a Consensus on the Immunohistochemical Detection of ERβ in Archival Formalin-ﬁxed Paraffin Embedded Human Breast Tissue

V. Speirs, P. Carder, C. Witton, 2005, Breast Cancer Research and Treatment.

Correspondence re: S. A. W. Fuqua et al., Estrogen receptor beta protein in human breast cancer: correlation with clinical tumor parameters. Cancer Res.,63: 2434-2439, 2003.

V. Speirs, 2003, Cancer research.

Breast cancer cell lines: friend or foe?

Valerie Speirs, Andrew M Hanby, V. Speirs, 2003, Breast Cancer Research.

Activity and gene expression of 17β-hydroxysteroid dehydrogenase type I in primary cultures of epithelial and stromal cells derived from normal and tumourous human breast tissue: the role of IL-8

A. Green, V. Speirs, S. Atkin, 1998, The Journal of Steroid Biochemistry and Molecular Biology.

Evidence for transcriptional activation of ERalpha by IL-1beta in breast cancer cells.

A. Green, M. Kerin, V. Speirs, 1999, International journal of oncology.

Cytokine expression in human anterior pituitary adenomas

V. Speirs, S. Atkin, V. Green, 1996, Clinical endocrinology.

Constitutive co‐expression of estrogen and progesterone receptor mRNA in human meningiomas by RT‐PCR and response of in vitro cell cultures to steroid hormones

V. Speirs, W. Fraser, E. Boyle-Walsh, 1997, International journal of cancer.

Loss of CSMD1 expression disrupts mammary duct formation while enhancing proliferation, migration and invasion.

V. Speirs, M. Kamal, C. Toomes, 2017, Oncology reports.

Loss of CSMD 1 expression disrupts mammary duct formation while enhancing proliferation , migration and invasion

V. Speirs, M. Kamal, C. Toomes, 2017 .

Vascular endothelial growth factor in premenopausal women--indicator of the best time for breast cancer surgery?

P. Drew, J. Monson, M. Kerin, 1998, British Journal of Cancer.

Collagenase III: A superior enzyme for complete disaggregation and improved viability of normal and malignant human breast tissue

A. Green, V. Speirs, M. White, 1996, In Vitro Cellular & Developmental Biology - Animal.

Evaluation of seven oestrogen receptor β antibodies for immunohistochemistry, western blotting, and flow cytometry in human breast tissue

V. Speirs, P. Carder, G. Skliris, 2002, The Journal of pathology.

Identification of differentially expressed genes in matched formalin‐fixed paraffin‐embedded primary and metastatic melanoma tumor pairs

V. Speirs, J. Newton-Bishop, C. Conway, 2012, Pigment cell & melanoma research.

Paracrine control of differentiation in the alveolar carcinoma, A549, by human foetal lung fibroblasts.

V. Speirs, R. Freshney, K. Ray, 1991, British Journal of Cancer.

The Estrogen Receptors α, β, and βcx

V. Speirs, A. Shaaban, 2005, Clinical Cancer Research.

Oestrogen receptor beta in breast cancer: good, bad or still too early to tell?

V. Speirs, 2002, The Journal of pathology.

Regulation of estrogen receptor β1 expression in breast cancer by epigenetic modification of the 5' regulatory region.

M. D. Parker, V. Speirs, P. Burns, 2013, International journal of oncology.

Articles selected from Faculty of 1000 in March 2003

V. Speirs, 2003, Breast Cancer Research.

Phyto-oestrogens and breast cancer chemoprevention

V. Speirs, J. Limer, 2004, Breast Cancer Research.

Male Breast Cancer

V. Speirs, A. Shaaban, M. Humphries, 2019, Breast Pathology.

Articles selected in December 2003

V. Speirs, 2004, Breast Cancer Research.

Activity of interferon alpha, interleukin 6 and insulin in the regulation of differentiation in A549 alveolar carcinoma cells.

V. Speirs, R. Freshney, C. McCormick, 1995, British Journal of Cancer.

CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid‐specific cancer cell death through autophagy induction

Nicolai J. Birkbak, Z. Szallasi, A. Rowan, 2012, The Journal of pathology.

Clinical and functional significance of loss of caveolin‐1 expression in breast cancer‐associated fibroblasts

V. Speirs, A. Hanby, S. Simpkins, 2012, The Journal of pathology.

Conditions of the male breast: Gynaecomastia and male breast cancer (Review).

V. Speirs, A. Shaaban, H. Honarpisheh, 2009, Molecular medicine reports.

Metastatic-niche labelling reveals parenchymal cells with stem features

S. Horswell, V. Speirs, P. Chakravarty, 2019, Nature.

Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness

C. Isacke, V. Speirs, E. Sahai, 2016, Nature Communications.

Expression of prostate specific antigen in male breast cancer

V. Speirs, P. Carder, M. Lansdown, 2004, Journal of Clinical Pathology.

Reduced expression of oestrogen receptor β in invasive breast cancer and its re‐expression using DNA methyl transferase inhibitors in a cell line model

V. Speirs, K. Horgan, A. Markham, 2003, The Journal of pathology.

Increased expression of estrogen receptor beta mRNA in tamoxifen-resistant breast cancer patients.

M. Kerin, V. Speirs, S. Atkin, 1999, Cancer research.

Estrogen receptor {beta}1 expression is regulated by miR-92 in breast cancer.

V. Speirs, P. Burns, A. Shaaban, 2010, Cancer research.

Differential Expression of MicroRNAs in Breast Cancers from Four Different Ethnicities

V. Speirs, P. Burns, A. Shaaban, 2018, Pathobiology.

Identification of MAGEA antigens as causal players in the development of tamoxifen-resistant breast cancer

V. Speirs, Amar S. Ahmad, C. Chelala, 2014, Oncogene.

Analysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression

G. Ciliberto, V. Speirs, I. Vitale, 2017, Scientific Reports.

In vivo models in breast cancer research: progress, challenges and future directions

Karen Blyth, Ingunn Holen, Bethny Morrissey, 2017, Disease Models & Mechanisms.

A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis

Pamela F. Jones, T. Pawson, V. Speirs, 2015, Nature Communications.

Functional inactivation of the oestrogen receptor by the antioestrogen, ZM 182780, sensitises tumour cells to reactive oxygen species.

V. Speirs, S. Atkin, G. Stalla, 1999, The Journal of endocrinology.

Loss of CSMD1 expression is associated with high tumour grade and poor survival in invasive ductal breast carcinoma

V. Speirs, M. Kamal, C. Toomes, 2010, Breast Cancer Research and Treatment.

Oestrogen receptor β (ERβ) regulates osteogenic differentiation of human dental pulp cells

J. Beattie, V. Speirs, G. Feichtinger, 2017, The Journal of Steroid Biochemistry and Molecular Biology.

Relationship between quantitative estrogen and progesterone receptor expression and human epidermal growth factor receptor 2 (HER-2) status with recurrence in the Arimidex, Tamoxifen, Alone or in Combination trial.

Jack Cuzick, Valerie Speirs, Mitch Dowsett, 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Production of VEGF and expression of the VEGF receptors Flt-1 and KDR in primary cultures of epithelial and stromal cells derived from breast tumours

V. Speirs, S. Atkin, Stephen L. Atkin, 1999, British Journal of Cancer.

MiR-26b is down-regulated in carcinoma-associated fibroblasts from ER-positive breast cancers leading to enhanced cell migration and invasion

Valerie Speirs, Andrew M Hanby, Alexandre Zougman, 2013, The Journal of pathology.

Articles selected from Faculty of 1000 in July 2003

V. Speirs, 2003, Breast Cancer Research.

Articles selected from Faculty of 1000 in January 2003

V. Speirs, 2003, Breast Cancer Research.

Microcephalin is a new novel prognostic indicator in breast cancer associated with BRCA1 inactivation

I. Ellis, A. Green, V. Speirs, 2011, Breast Cancer Research and Treatment.

British Cancer Research Meeting, 30 June-3 July 2002, Glasgow

V. Speirs, A. Parkes, 2002, Breast Cancer Research.

Genetic changes in breast cancer detected by comparative genomic hybridisation

P J Drew, J R Monson, P. Drew, 2000, International journal of cancer.

Characterisation of male breast cancer: a descriptive biomarker study from a large patient series

I. Ellis, S. Shousha, E. Provenzano, 2017, Scientific Reports.

Management and 5-year outcomes in 9938 women with screen-detected ductal carcinoma in situ: the UK Sloane Project.

G. Ball, S. Lakhani, S. Pinder, 2018, European journal of cancer.

Pre-Clinical Modeling of Breast Cancer: Which Model to Choose?

V. Speirs, Claire Nash, 2013 .

Down-Regulation of miR-92 in Breast Epithelial Cells and in Normal but Not Tumour Fibroblasts Contributes to Breast Carcinogenesis

Valerie Speirs, Lucy F. Stead, Lucy F Stead, 2015, PloS one.

Insulin-like growth factor - oestradiol crosstalk and mammary gland tumourigenesis.

J. Beattie, V. Speirs, C. Twelves, 2013, Biochimica et biophysica acta.

The Hippo transducers TAZ/YAP and their target CTGF in male breast cancer

V. Speirs, M. Mottolese, A. Shaaban, 2016, Oncotarget.

Epithelial–mesenchymal interactions in breast cancer: evidence for a role of nuclear localized β‐catenin in carcinoma‐associated fibroblasts

V. Speirs, V. Cookson, A. Hanby, 2011, Histopathology.

Current and Emerging 3D Models to Study Breast Cancer.

Valerie Speirs, S. Peyman, V. Speirs, 2019, Advances in experimental medicine and biology.

CAPG and GIPC1: Breast Cancer Biomarkers for Bone Metastasis Development and Treatment

I. Holen, V. Speirs, Jianhe Peng, 2016, Journal of the National Cancer Institute.

Direct activation of oestrogen receptor- α by interleukin-6 in primary cultures of breast cancer epithelial cells

M. Kerin, V. Speirs, S. Atkin, 2000, British Journal of Cancer.

Coexpression of Estrogen Receptor α and β: Poor Prognostic Factors in Human Breast Cancer?

M. Kerin, V. Speirs, S. Atkin, 1999 .

Interleukin‐3: A putative protective factor against breast cancer which is secreted by male but not female breast fibroblasts

A. Green, V. Speirs, M. Birch, 1995, International journal of cancer.

The potential utility of geminin as a predictive biomarker in breast cancer

V. Speirs, K. Horgan, H. Thygesen, 2013, Breast Cancer Research and Treatment.

Development and characterisation of a 3D multi-cellular in vitro model of normal human breast: a tool for cancer initiation studies

D. Treanor, V. Speirs, E. Baxter, 2015, Oncotarget.

The anti-estrogen tamoxifen blocks the stimulatory effects of interleukin-6 on 17β-hydroxysteroid dehydrogenase activity in MCF-7 cells

V. Speirs, M. White, E. Adams, 1993, The Journal of Steroid Biochemistry and Molecular Biology.

Estrogen receptor β: putting a positive into triple negative breast cancer?

V. Speirs, Laura Smith, T. Hughes, 2013, Hormone molecular biology and clinical investigation.

Genetic events during the transformation of a tamoxifen-sensitive human breast cancer cell line into a drug-resistant clone.

K. Maclennan, V. Speirs, K. Horgan, 2001, Cancer genetics and cytogenetics.

Tissue microarrays--big potential from small samples (review).

V. Speirs, A. Hanby, K. Horgan, 2004, International journal of oncology.

Male breast cancer: an update

S. Fox, V. Speirs, A. Shaaban, 2021, Virchows Archiv.

Mechanisms of FGFR3 actions in endocrine resistant breast cancer

V. Speirs, M. Knowles, D. Tomlinson, 2012, International journal of cancer.

Wnt signalling in mammary carcinogenesis

V. Speirs, 2002, Breast Cancer Research.

A comparative biomarker study of 514 matched cases of male and female breast cancer reveals gender-specific biological differences

G. Ball, S. Shousha, E. Provenzano, 2012, Breast Cancer Research and Treatment.

Properties and characteristics of the dyes injected to assist axillary sentinel node localization in breast surgery.

V. Speirs, K. Horgan, A. Hanby, 2006, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

Differential regulation of oestrogen receptor β isoforms by 5′ untranslated regions in cancer

V. Speirs, A. Shaaban, Laura Smith, 2009, Journal of cellular and molecular medicine.

A Global View of Breast Tissue Banking.

V. Speirs, H. Wilson, Ben Botfield, 2015, Advances in experimental medicine and biology.

Expression of COX-2, NF-κB-p65, NF-κB-p50 and IKKα in malignant and adjacent normal human colorectal tissue

V. Speirs, T. Lightfoot, N. Gooderham, 2009, British Journal of Cancer.

Changes in expression of steroid receptors, their downstream target genes and their associated co-regulators during the sequential acquisition of tamoxifen resistance in vitro.

V. Speirs, F. Ponchel, M. Cummings, 2007, International journal of oncology.

Deregulation of IGF-binding proteins -2 and -5 contributes to the development of endocrine resistant breast cancer in vitro

J. Beattie, V. Speirs, C. Twelves, 2016, Oncotarget.

Incidence of male breast cancer in Scotland over a twenty-five-year period (1992-2017).

V. Speirs, Peng Liu, Y. Masannat, 2020, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

Preclinical models of glioblastoma: limitations of current models and the promise of new developments

V. Speirs, D. Veljanoski, A. Brüning-Richardson, 2021, Expert Reviews in Molecular Medicine.

Defining genomic, transcriptomic, proteomic, epigenetic, and phenotypic biomarkers with prognostic capability in male breast cancer: a systematic review.

V. Speirs, P. Liu, B. Elsberger, 2023, The Lancet. Oncology.

Androgen receptor and antiandrogen therapy in male breast cancer.

V. Speirs, M. Mottolese, D. Santini, 2015, Cancer letters.

Role of gonadotropin-releasing hormone analogues in metastatic male breast cancer: results from a pooled analysis

V. Speirs, M. Mottolese, D. Santini, 2015, Journal of Hematology & Oncology.

Antiandrogen therapy in metastatic male breast cancer: results from an updated analysis in an expanded case series

R. Maria, V. Speirs, M. Rinaldi, 2014, Breast Cancer Research and Treatment.

Male breast carcinoma: increased awareness needed

Jonathan White, Valerie Speirs, Andrew M Hanby, 2011, Breast Cancer Research.

Problems (and solutions) in the study of male breast cancer

V. Speirs, A. Shaaban, A. Hanby, 2010, Rare tumors.

Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity

V. Speirs, A. Shaaban, J. McElwaine, 2009, British Journal of Cancer.

Stanniocalcin 2 expression is associated with a favourable outcome in male breast cancer

E. Provenzano, V. Speirs, L. Jordan, 2018, The journal of pathology. Clinical research.

Quality Considerations When Using Tissue Samples for Biomarker Studies in Cancer Research

V. Speirs, 2021, Biomarker insights.

Tamoxifen-resistant Breast Cancer Patients mRNA in β Increased Expression of Estrogen Receptor

V. Speirs, D. Walton, C. Malone, 2013 .

PSMD9 expression predicts radiotherapy response in breast cancer

V. Speirs, D. Dodwell, K. Horgan, 2014, Molecular Cancer.

Characterisation of the tumour suppressor gene ZAC in breast tissue

V. Speirs, D. Bonthron, Ema Valleley, 2006, Breast Cancer Research.

SEARCHBreast Workshop Proceedings: 3D Modelling of Breast Cancer

I. Holen, V. Speirs, C. Chelala, 2015, Alternatives to laboratory animals : ATLA.

The practicalities of using tissue slices as preclinical organotypic breast cancer models

V. Speirs, A. Shaaban, A. Hanby, 2012, Journal of Clinical Pathology.

Gene Expression of ERβ Isoforms in Laser Microdissected Human Breast Cancers: Implications for Gene Expression Analyses

V. Speirs, A. Shaaban, M. Cummings, 2009, Cellular oncology : the official journal of the International Society for Cellular Oncology.

Nuclear and Cytoplasmic Expression of ERβ1, ERβ2, and ERβ5 Identifies Distinct Prognostic Outcome for Breast Cancer Patients

I. Ellis, A. Green, J. Robertson, 2008, Clinical Cancer Research.

Modelling the Molecular Pathology of Breast Cancer Initiation

V. Speirs, A. Hanby, Claire Nash, 2015 .

Clinical importance of estrogen receptor beta isoforms in breast cancer.

I. Ellis, A. Green, V. Speirs, 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Signalling by Steroid Receptors

V. Speirs, 2007 .

New perspectives into the biological and clinical relevance of oestrogen receptors in the human breast

V. Speirs, R. Walker, R. Walker, 2007, The Journal of pathology.

ERβ1 represses FOXM1 expression through targeting ERα to control cell proliferation in breast cancer.

Valerie Speirs, Matti Poutanen, Johan Hartman, 2011, The American journal of pathology.

Adding value to rare tissue samples donated to biobanks: characterisation of breast tissue and primary cell cultures obtained from a female-to-male transgender patient

V. Speirs, K. Horgan, R. Chalkley, 2015, Cell and Tissue Banking.

Clinicians' guide to microarrays.

V. Speirs, M. Peter, L. Maraqa, 2006, Surgical oncology.

CIP2A expression predicts recurrences of tamoxifen-treated breast cancer

V. Speirs, G. Grech, C. Scerri, 2017, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

CIP 2 A expression predicts recurrences of tamoxifen-treated breast cancer

V. Speirs, G. Grech, C. Scerri, 2017 .

Radiotherapy biobanking: current landscape, opportunities, challenges, and future aspirations

N. Curtin, V. Speirs, T. Ward, 2021, The journal of pathology. Clinical research.

Biobanking in radiotherapy trials — a challenge to the clinical research community

V. Speirs, D. Gilbert, 2021, Nature Reviews Clinical Oncology.

Rapid and irreversible loss of estrogen receptor in human osteoblast-like cells following culture in phenol red-free medium

V. Speirs, J. Nasir, 1997, In Vitro Cellular & Developmental Biology - Animal.

Reflections on the upsurge of virtual cancer conferences during the COVID-19 pandemic

Valerie Speirs, V. Speirs, 2020, British Journal of Cancer.

Oestrogen receptor β in breast cancer: good, bad or still too early to tell?

V. Speirs, 2002 .

Identification and validation of DOCK4 as a potential biomarker for risk of bone metastasis development in patients with early breast cancer

M. Dunning, V. Speirs, P. Selby, 2019, The Journal of pathology.

Growth factor regulation of 17 beta-hydroxysteroid dehydrogenase activity in a human ovarian cell line: modulation by 17 beta-estradiol.

V. Speirs, M. White, S. Jenkins, 1993, Anticancer research.

Interactive effects of interleukin-6, 17 beta-estradiol and progesterone on growth and 17 beta-hydroxysteroid dehydrogenase activity in human breast carcinoma cells.

V. Speirs, B. Rafferty, M. White, 1993, The Journal of steroid biochemistry and molecular biology.

Identification of wild-type and exon 5 deletion variants of estrogen receptor beta in normal human mammary gland.

V. Speirs, S. Atkin, D. Walton, 2000, The Journal of clinical endocrinology and metabolism.

Normal mammary epithelial cells escape of senescence

V. Speirs, 2001, Breast Cancer Research.

Three‐dimensional reconstruction of ductal carcinoma in situ with virtual slides

Darren Treanor, Valerie Speirs, Derek R Magee, 2015, Histopathology.

Hormone Receptors in Breast Cancer

V. Speirs, A. Shaaban, 2019, Breast Pathology.

External validation of the ImmunoRatio image analysis application for ERα determination in breast cancer

V. Speirs, K. Horgan, A. Hanby, 2013, Journal of Clinical Pathology.

Estrogen receptor regulation: don’t forget translation

V. Speirs, Laura Smith, T. Hughes, 2010, Breast Cancer Research and Treatment.

Prognostic significance of oestrogen receptor β in breast cancer

V. Speirs, M. Kerin, Michael J. Kerin, 2000 .

Obesity and male breast cancer: provocative parallels?

V. Speirs, V. Jordan, V. Jordan, 2015, BMC Medicine.

The prognostic significance of tumour–stroma ratio in oestrogen receptor-positive breast cancer

J Kulka, V. Speirs, A. Hanby, 2014, British Journal of Cancer.

Correspondence re: K. Heer et al., serum vascular endothelial growth factor in breast cancer: its relation with cancer type and estrogen receptor status. Clin. Cancer Res., 7: 3491-3494, 2001.

V. Speirs, P. Carder, M. Lansdown, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Systemic and neurologic abnormalities distinguish the lysosomal disorders sialidosis and galactosialidosis in mice

V. Speirs, J. Isaacs, F. Ponchel, 2002 .

Expression of regulators of mitotic fidelity are associated with intercellular heterogeneity and chromosomal instability in primary breast cancer

Nicolai J. Birkbak, C. Swanton, V. Speirs, 2014, Breast Cancer Research and Treatment.

Characterising the adipose-inflammatory microenvironment in male breast cancer.

V. Speirs, M. Humphries, Angharad Cullinane, 2018, Endocrine-related cancer.

The value of archival tissue blocks in understanding breast cancer biology

V. Speirs, A. Hanby, T. Dowsett, 2013, Journal of Clinical Pathology.

Perspective: Not just for women

V. Speirs, 2012, Nature.

The Sharing Experimental Animal Resources, Coordinating Holdings (SEARCH) Framework: Encouraging Reduction, Replacement, and Refinement in Animal Research

Claude Chelala, Phil Carter, Karen Blyth, 2017, PLoS biology.

SEARCHBreast: a new resource to locate and share surplus archival material from breast cancer animal models to help address the 3Rs

I. Holen, V. Speirs, C. Chelala, 2016, Breast Cancer Research and Treatment.

Animal research: Share surplus animal tissue

V. Speirs, 2015, Nature.

Tspan6 stimulates the chemoattractive potential of breast cancer cells for B cells in an EV- and LXR-dependent manner.

S. Hayward, V. Speirs, S. V. van Laere, 2023, Cell reports.

Breast cancer: Investment biobanking—increased returns from tissue samples

V. Speirs, A. Morgan, 2013, Nature Reviews Clinical Oncology.

Oestrogen receptor beta: what it means for patients with breast cancer.

V. Speirs, D. Dodwell, P. Carder, 2004, The Lancet. Oncology.

Evaluation of applying IHC4 as a prognostic model in the translational study of Intergroup Exemestane Study (IES): PathIES

P. Lønning, M. Cheang, V. Speirs, 2017, Breast Cancer Research and Treatment.

Estrogen receptor β—which one and where should we draw the line?

V. Speirs, A. Shaaban, 2006 .

Identification of stage-specific breast markers using quantitative proteomics.

K. Kyriacou, V. Speirs, M. Loizidou, 2013, Journal of proteome research.

Male versus female breast cancer: a comparative study of 523 matched cases reveals differences behind similarity

G. Ball, V. Speirs, 2010, Breast Cancer Research.

Carcinoembryonic Antigen Cell Adhesion Molecule 6 Predicts Breast Cancer Recurrence following Adjuvant Tamoxifen

V. Speirs, K. Horgan, A. Shaaban, 2008, Clinical Cancer Research.

17Beta-hydroxysteroid dehydrogenase type 1, 2, 3, and 4 expression and enzyme activity in human anterior pituitary adenomas.

V. Speirs, S. Atkin, V. Green, 1999, The Journal of clinical endocrinology and metabolism.

The evolving role of oestrogen receptor beta in clinical breast cancer

V. Speirs, 2008, Breast Cancer Research.

Editorial The evolving role of oestrogen receptor β in clinical breast cancer

V. Speirs, 2008 .

MicroRNA-92 targets the 3' untranslated region of ERβ1 mRNA and post-transcriptionally regulates its expression in breast cancer

V. Speirs, A. Hanby, M. Cummings, 2010, Breast Cancer Research.

Articles selected in September 2004

V. Speirs, 2004, Breast Cancer Research.

Biglycan and reduced glycolysis are associated with breast cancer cell dormancy in the brain

Christopher M. Fife, V. Speirs, A. Droop, 2023, Frontiers in Oncology.

Advances in the development of improved animal-free models for use in breast cancer biomedical research

V. Speirs, Sophie Roberts, 2017, Biophysical Reviews.

Analysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression

G. Ciliberto, V. Speirs, I. Vitale, 2017, Scientific Reports.

The SEARCHBreast portal: a virtual bioresource to facilitate the sharing of surplus animal materials derived from breast cancer studies

Claude Chelala, Louise Jones, Phil Carter, 2016 .

Validation of a 3D perfused cell culture platform as a tool for humanised preclinical drug testing in breast cancer using established cell lines and patient-derived tissues

V. Speirs, D. Tomlinson, J. T. Shoemaker, 2023, PloS one.

Interleukin-6 (IL-6) production and cell growth of cultured human ameningiomas:-interactions with interleukin-1 beta (IL-1 beta) and interleukin-4 (IL-4) in vitro.

V. Speirs, E. Boyle-Walsh, M. White, 1994, Neuroscience letters.

miR-92 Is a Novel Regulator of ERβ1 Expression in Breast Cancer.

V. Speirs, P. Burns, A. Shaaban, 2009 .

Downregulation of 15-hydroxyprostaglandin dehydrogenase during acquired tamoxifen resistance and association with poor prognosis in ERα-positive breast cancer.

B. Broom, H. Brauch, V. Speirs, 2020, Exploration of targeted anti-tumor therapy.

MCPH1, a potential predictor for response to cancer chemotherapy

V. Speirs, S. Bell, E. Morrison, 2008 .

Expression of COX-2, NF-κB-p65, NF-κB-p50 and IKKα in malignant and adjacent normal human colorectal tissue

V. Speirs, T. Lightfoot, K. Horgan, 2009, British Journal of Cancer.

Articles selected in February 2004

V. Speirs, 2004, Breast Cancer Research.

Evaluation of applying IHC4 as a prognostic model in the translational study of Intergroup Exemestane Study (IES): PathIES

P. Lønning, M. Cheang, V. Speirs, 2017, Breast Cancer Research and Treatment.

Cytokine Expression in Normal and Neoplastic Breast Tissue

A. Green, V. Speirs, V. Todd, 1995 .

Molecular cytogenetic analysis of breast cancer cell lines

Valerie Speirs, V. Speirs, 2000, Breast Cancer Research.

Exploring the influence of rural residence on uptake of organized cancer screening - A systematic review of international literature.

V. Speirs, P. Murchie, L. Iversen, 2021, Cancer epidemiology.

SEARCHBreast: a new online resource to make surplus material from in vivo models of breast cancer visible and accessible to researchers

I. Holen, V. Speirs, C. Chelala, 2016, Breast Cancer Research.

SEARCHBreast: An online resource designed to increase the efficiency of using materials derived from breast cancer studies in animals

I. Holen, V. Speirs, C. Chelala, 2016, Journal of Pathology.

Male breast carcinoma: increased awareness needed

V. Speirs, D. Dodwell, K. Horgan, 2011, Breast Cancer Research.

CIP2A expression predicts recurrences of tamoxifen-treated breast cancer

V. Speirs, G. Grech, C. Scerri, 2017, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

Oestrogen receptor β immunohistochemistry: time to get it right?

V. Speirs, A. Shaaban, C. Green, 2008 .

Pulmonary neuroendocrine cells in cultures of human infant airway mucosa from postmortem tissues.

V. Speirs, H. Yeger, E. Cutz, 1996, American journal of respiratory cell and molecular biology.

Oestrogen receptor beta immunohistochemistry: time to get it right?

V. Speirs, A. Shaaban, C. Green, 2008, Journal of clinical pathology.

Angiogenesis in breast cancer: how should we measure this? (Review).

Pamela F. Jones, V. Speirs, K. Horgan, 2005, Oncology reports.

MicroRNA-495/TGF-β/FOXC1 axis regulates multidrug resistance in metaplastic breast cancer cells.

Simak Ali, E. Yagüe, V. Speirs, 2021, Biochemical Pharmacology.

Gene Expression of ERβ Isoforms in Laser Microdissected Human Breast Cancers: Implications for Gene Expression Analyses

V. Speirs, A. Shaaban, M. Cummings, 2009, Cellular oncology : the official journal of the International Society for Cellular Oncology.

Primary Culture of Human Mammary Tumor Cells

V. Speirs, 2005 .

Management of breast cancer in an Asian man with post-traumatic stress disorder: a case report

V. Speirs, A. Hanby, R. Achuthan, 2016, Journal of Medical Case Reports.