S. Spiegel

发表

Sphingosine kinase, sphingosine-1-phosphate, and apoptosis.

M. Maceyka, S. Payne, S. Milstien, 2002, Biochimica et biophysica acta.

The Histone Deacetylase Inhibitor MS-275 Interacts Synergistically with Fludarabine to Induce Apoptosis in Human Leukemia Cells

D. Paik, S. Payne, S. Spiegel, 2004, Cancer Research.

Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G protein-dependent mechanism

S. Spiegel, T. Sturgill, J. Wu, 1995, The Journal of Biological Chemistry.

Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets

Cheng Luo, Bairong Shen, Zhongjie Liang, 2015, Scientific Reports.

Preferential Signaling and Induction of Allergy-promoting Lymphokines Upon Weak Stimulation of the High Affinity IgE Receptor on Mast Cells

J. P. Hobson, S. Spiegel, J. Penninger, 2003, The Journal of experimental medicine.

EGF regulates plasminogen activator inhibitor‐1 (PAI‐1) by a pathway involving c‐Src, PKCδ, and sphingosine kinase 1 in glioblastoma cells

Barbara S. Paugh, S. Milstien, S. Spiegel, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Sphingosine-1-Phosphate and Interleukin-1 Independently Regulate Plasminogen Activator Inhibitor-1 and Urokinase-Type Plasminogen Activator Receptor Expression in Glioblastoma Cells: Implications for Invasiveness

Barbara S. Paugh, S. Milstien, S. Spiegel, 2008, Molecular Cancer Research.

Export of sphingosine-1-phosphate and cancer progression

Sarah Spiegel, Kazuaki Takabe, S. Spiegel, 2014, Journal of Lipid Research.

A simple method for sphingolipid analysis of tissues embedded in optimal cutting temperature compound[S]

S. Spiegel, Timothy D. Rohrbach, April E. Boyd, 2020, Journal of Lipid Research.

Targeting the Sphingosine-1-Phosphate Axis for Developing Non-narcotic Pain Therapeutics.

S. Spiegel, D. Salvemini, S. Squillace, 2020, Trends in pharmacological sciences.

Apoptosis induces expression of sphingosine kinase 1 to release sphingosine‐1‐phosphate as a “come‐and‐get‐me” signal

S. Milstien, S. Spiegel, Sergio E Alvarez, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Sphingosine-1-phosphate synthesis and functions in mast cells.

S. Milstien, S. Spiegel, C. Oskeritzian, 2008, Future lipidology.

Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis.

S. Milstien, S. Spiegel, C. Oskeritzian, 2007, Pharmacology & therapeutics.

Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors.

S. Payne, S. Milstien, S. Spiegel, 2005, Blood.

Role of Sphingosine Kinase 2 in Cell Migration toward Epidermal Growth Factor*

M. Maceyka, S. Milstien, S. Spiegel, 2005, Journal of Biological Chemistry.

Expression of SphK 1 impairs degranulation and motility of RBL-2 H 3 mast cells by desensitizing S 1 P receptors

S. Payne, S. Milstien, S. Spiegel, 2005 .

Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720*

R. Proia, S. Spiegel, A. Olivera, 2004, Journal of Biological Chemistry.

Transactivation of Sphingosine-1–Phosphate Receptors by FcɛRI Triggering Is Required for Normal Mast Cell Degranulation and Chemotaxis

R. Proia, S. Milstien, S. Spiegel, 2004, The Journal of experimental medicine.

Pleiotropic actions of sphingosine-1-phosphate.

S. Milstien, S. Spiegel, H. Sankala, 2003, Progress in lipid research.

Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells.

J. P. Hobson, S. Milstien, S. Spiegel, 2002, Experimental cell research.

Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology.

S. Spiegel, J. Shayman, A. Merrill, 1997, Toxicology and applied pharmacology.

Sphingosine 1‐phosphate: a prototype of a new class of second messengers

S. Spiegel, 1999, Journal of leukocyte biology.

Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death.

S. Spiegel, A. Olivera, I. Galve-Roperh, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts.

S. Milstien, S. Spiegel, P. Dent, 2009, Cancer research.

Lysophospholipid (LPA) receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

S. Spiegel, Y. Yung, J. Chun, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Lysophospholipid (S1P) receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

S. Spiegel, J. Chun, V. Blaho, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Independently of CD95 (APO-1/Fas) Signaling Liposomal ET-18-OCH3 Induces Cytochrome c-Mediated Apoptosis

S. Spiegel, O. Cuvillier, A. Janoff, 2013 .

Liposomal ET-18-OCH(3) induces cytochrome c-mediated apoptosis independently of CD95 (APO-1/Fas) signaling.

S. Spiegel, O. Cuvillier, A. Janoff, 1999, Blood.

Sphingosine 1-Phosphate Stimulates Tyrosine Phosphorylation of Crk*

S. Spiegel, D. Beitner-Johnson, D. Leroith, 1997, The Journal of Biological Chemistry.

Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma.

M. Maceyka, S. Milstien, S. Spiegel, 2019, Handbook of experimental pharmacology.

Gangliosides do not move from apical to basolateral plasma membrane in cultured epithelial cells.

S. Spiegel, R. Blumenthal, P. Fishman, 1985, Biochimica et biophysica acta.

Asymmetric distribution of gangliosides in rat renal brush-border and basolateral membranes.

S. Spiegel, G. Matyas, L. Cheng, 1988, Biochimica et biophysica acta.

Deletion or inhibition of SphK1 mitigates fulminant hepatic failure by suppressing TNFα‐dependent inflammation and apoptosis

S. Spiegel, K. Harikumar, A. Sanyal, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A GTPase-independent Mechanism of p21-activated Kinase Activation

A. M. Reilly, C. C. King, S. Spiegel, 1998, The Journal of Biological Chemistry.

The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses.

S. Milstien, S. Spiegel, J. Ryan, 2015, The Journal of allergy and clinical immunology.

Lipid mediators of angiogenesis and the signalling pathways they initiate.

S. Spiegel, J. Garcia, D. Brindley, 2002, Biochimica et biophysica acta.

PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.

P. Fisher, S. Spiegel, P. Dent, 2010, Cancer research.

Targeting defective sphingosine kinase 1 in Niemann–Pick type C disease with an activator mitigates cholesterol accumulation

M. Maceyka, S. Milstien, S. Spiegel, 2020, The Journal of Biological Chemistry.

Niemann-Pick type C disease: The atypical sphingolipidosis.

S. Milstien, S. Spiegel, J. Newton, 2018, Advances in biological regulation.

Sphingosine‐1‐phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans

M. Maceyka, S. Milstien, S. Spiegel, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.

Eugene Y. Kim, S. Milstien, S. Spiegel, 2013, Cancer cell.

A novel role for mitochondrial sphingosine-1-phosphate produced by sphingosine kinase-2 in PTP-mediated cell survival during cardioprotection

S. Spiegel, Qun Chen, E. Lesnefsky, 2011, Basic Research in Cardiology.

Sphingosine-1-Phosphate Phosphohydrolase Regulates Endoplasmic Reticulum-to-Golgi Trafficking of Ceramide

M. Maceyka, S. Milstien, S. Spiegel, 2006, Molecular and Cellular Biology.

Deoxycholic Acid Activates the c-Jun N-terminal Kinase Pathway via FAS Receptor Activation in Primary Hepatocytes

S. Payne, S. Spiegel, P. Dent, 2004, Journal of Biological Chemistry.

Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation

S. Spiegel, T. Vanderah, D. Salvemini, 2017, Pain.

Regulation and functions of sphingosine kinases in the brain.

S. Milstien, S. Spiegel, Lauren Bryan, 2008, Biochimica et biophysica acta.

Bioactive lipids and metabolic syndrome—a symposium report

G. Shulman, E. Dennis, S. Spiegel, 2022, Annals of the New York Academy of Sciences.

Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy

S. Milstien, S. Spiegel, P. Dent, 2011, Cell Death and Differentiation.

Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics.

M. Maceyka, S. Milstien, S. Spiegel, 2005, Prostaglandins & other lipid mediators.

Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cells.

S. Spiegel, H. Zhang, N. N. Desai, 1990, The Journal of biological chemistry.

Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics.

S. Milstien, S. Spiegel, 2006, Cancer cell.

Sphingosine‐1‐phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration

D. C. Simpson, M. Maceyka, S. Milstien, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Thematic Review Series: Sphingolipids. Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling*1

S. Spiegel, D. Lebman, Deborah A. Lebman, 2008 .

Differential regulation of autophagy and cell viability by ceramide species

S. Spiegel, P. Dent, N. Cruickshanks, 2015, Cancer biology & therapy.

Regulation of fibroblast functions by lysophospholipid mediators: Potential roles in wound healing

S. Spiegel, R. Diegelmann, K. Watterson, 2007, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

The outs and the ins of sphingosine-1-phosphate in immunity

S. Milstien, S. Spiegel, 2011, Nature Reviews Immunology.

Sphingolipids in metabolic disease: The good, the bad, and the unknown.

M. Maceyka, S. Spiegel, L. Cowart, 2021, Cell metabolism.

Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.

S. Milstien, S. Spiegel, X. Fang, 2008, Cancer research.

A new preclinical model of western diet‐induced progression of non‐alcoholic steatohepatitis to hepatocellular carcinoma

S. Spiegel, P. Bedossa, A. Sanyal, 2022, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Arabidopsis Sphingosine Kinase and the Effects of Phytosphingosine-1-Phosphate on Stomatal Aperture1[w]

S. Spiegel, S. Assmann, S. Gilroy, 2005, Plant Physiology.

Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins

S. Spiegel, S. Assmann, L. Fan, 2003, Nature.

Copper dependence of angioproliferation in pulmonary arterial hypertension in rats and humans.

M. Humbert, S. Spiegel, E. Fadel, 2012, American journal of respiratory cell and molecular biology.

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.

Barbara S. Paugh, S. Milstien, S. Spiegel, 2008, Blood.

Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling

S. Spiegel, C. Chalfant, 2005, Journal of Cell Science.

OSU-03012 stimulates PERK-dependent increases in HSP 70 expression , attenuating its lethal actions in transformed cells

P. Fisher, S. Spiegel, C. Chen, 2007 .

The nuclear matrix protein, numatrin (B23), is associated with growth factor-induced mitogenesis in Swiss 3T3 fibroblasts and with T lymphocyte proliferation stimulated by lectins and anti-T cell antigen receptor antibody

S. Spiegel, N. Feuerstein, J. Mond, 1988, The Journal of cell biology.

Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology

M. Maceyka, S. Spiegel, Timothy D. Rohrbach, 2017, Critical reviews in biochemistry and molecular biology.

Involvement of sphingosine kinase in plant cell signalling.

S. Spiegel, A. Hetherington, Sergio E Alvarez, 2008, The Plant journal : for cell and molecular biology.

An integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors.

S. Spiegel, R. Enriz, Sergio E Alvarez, 2017, European journal of medicinal chemistry.

Hepatic Apolipoprotein M (ApoM) Overexpression Stimulates Formation of Larger ApoM/Sphingosine 1-Phosphate-enriched Plasma High Density Lipoprotein*

S. Spiegel, A. Gebre, Jeongmin Seo, 2013, The Journal of Biological Chemistry.

A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma.

S. Milstien, S. Spiegel, D. Conrad, 2013, The Journal of allergy and clinical immunology.

Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods

S. Milstien, S. Spiegel, H. Miyazaki, 2016, Journal of Mammary Gland Biology and Neoplasia.

A specific ceramide kinase assay to measure cellular levels of ceramide.

S. Milstien, S. Spiegel, M. Bektas, 2003, Analytical biochemistry.

PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells

P. Fisher, S. Spiegel, P. Dent, 2008, Autophagy.

Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells

P. Fisher, S. Spiegel, P. Dent, 2008, Molecular Cancer Therapeutics.

Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice.

M. Maceyka, S. Milstien, S. Spiegel, 2015, The Journal of allergy and clinical immunology.

The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning

S. Spiegel, C. Stewart, I. Daar, 2003, Development.

The ORMDL3 Asthma Gene Regulates ICAM1 and Has Multiple Effects on Cellular Inflammation

S. Spiegel, M. Moffatt, Youming Zhang, 2019, American journal of respiratory and critical care medicine.

Sphingosine-1-phosphate signaling: A novel target for simultaneous adjuvant treatment of triple negative breast cancer and chemotherapy-induced neuropathic pain.

S. Spiegel, S. Singh, 2019, Advances in biological regulation.

Sphingosine kinase functionally links elevated transmural pressure and increased reactive oxygen species formation in resistance arteries

S. Spiegel, D. Lidington, S. Bolz, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Direct visualization of redistribution and capping of fluorescent gangliosides on lymphocytes

S. Kassis, M. Wilchek, S. Spiegel, 1984, The Journal of cell biology.

Role of ceramide in neuronal cell death and differentiation.

S. Spiegel, A. Faden, R. Toman, 2000, Journal of neurotrauma.

Sphingosine 1‐phosphate in neural signalling and function

S. Milstien, S. Spiegel, D. Gude, 2007, Acta paediatrica.

Sphingosine-1-phosphate: an emerging therapeutic target

S. Milstien, S. Spiegel, R. Toman, 2001, Expert opinion on therapeutic targets.

Primary Human Glioblastoma Multiforme Cells Induced Killing of −-7 / IL-24 mda Thioredoxin Play a Key Role in Dependent Regulation of Ceramide Synthase 6 and −

P. Fisher, S. Spiegel, P. Dent, 2010 .

Sphingoid bases and phospholipase D activation.

S. Milstien, S. Spiegel, 1996, Chemistry and physics of lipids.

Development of small-molecule inhibitors of sphingosine-1-phosphate signaling.

S. Milstien, S. Spiegel, Yvette M. Edmonds, 2011, Pharmacology & therapeutics.

Calcium influx inhibits MT1‐MMP processing and blocks MMP‐2 activation

S. Spiegel, Hiroshi Sato, M. Seiki, 1997, FEBS letters.

Sphingosine 1-Phosphate, a Key Cell Signaling Molecule*

S. Milstien, S. Spiegel, 2002, The Journal of Biological Chemistry.

The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2

S. Payne, S. Milstien, S. Spiegel, 2003, FEBS letters.

Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways.

S. Milstien, S. Spiegel, Sarah Spiegel, 2003, Biochemical Society transactions.

Autocrine and paracrine roles of sphingosine-1-phosphate

S. Milstien, S. Spiegel, Sergio E Alvarez, 2007, Trends in Endocrinology & Metabolism.

Enzymatic measurement of sphingosine 1-phosphate.

S. Spiegel, L. Edsall, Sarah Spiegel, 1999, Analytical biochemistry.

to Promote Gastric Cancer Cell Motility and Invasion Receptors Mediates Up-regulation of Sphingosine Kinase 1 and Epidermal Growth Factor 1 Cross-talk between LPA

S. Milstien, S. Spiegel, X. Fang, 2008 .

Conjugated bile acid–activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression

S. Spiegel, Runping Liu, P. Hylemon, 2015, Hepatology.

la,25-Dihydroxyvitamin D3 Inhibits Programmed Cell Death in HL-60 Cells by Activation of Sphingosine Kinase1

S. Spiegel, O. Cuvillier, B. Kleuser, 2006 .

Spinster 2, a sphingosine‐1‐phosphate transporter, plays a critical role in inflammatory and autoimmune diseases

M. Maceyka, S. Milstien, S. Spiegel, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A new wound healing agent--sphingosylphosphorylcholine.

S. Spiegel, T. Nielsen, L. Xu, 1996, The Journal of investigative dermatology.

Conjugated bile acids activate the sphingosine‐1‐phosphate receptor 2 in primary rodent hepatocytes

S. Spiegel, P. Dent, Xiqiao Zhou, 2012, Hepatology.

Critical role of acylglycerol kinase in epidermal growth factor-induced mitogenesis of prostate cancer cells.

S. Milstien, S. Spiegel, 2005, Biochemical Society transactions.

Number : DAMD 17-021-0060 TITLE : Lysophosphatidic Acid Regulation and Roles in Human Prostate Cancer

S. Spiegel, 2022 .

The potent lipid mitogen sphingosylphosphocholine activates the DNA binding activity of upstream stimulating factor (USF), a basic helix-loop-helix-zipper protein.

S. Spiegel, A. Berger, S. Segal, 1998, Biochimica et biophysica acta.

Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines.

S. Spiegel, N. N. Desai, Sarah Spiegel, 1991, Biochemical and biophysical research communications.

Structural requirements of sphingosylphosphocholine and sphingosine-1-phosphate for stimulation of activator protein-1 activity.

S. Spiegel, R. Bittman, R. Schmidt, 1996, Molecular pharmacology.

Sphingosylphosphocholine, a signaling molecule which accumulates in Niemann-Pick disease type A, stimulates DNA-binding activity of the transcription activator protein AP-1.

S. Spiegel, D. Rosenthal, A. Berger, 1995, Proceedings of the National Academy of Sciences of the United States of America.

FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice

S. Spiegel, P. Bedossa, A. Sanyal, 2019, Journal of Lipid Research.

FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann‐Pick type C mutant fibroblasts

M. Maceyka, S. Milstien, S. Spiegel, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

S. Spiegel, C. Futter, F. Platt, 2019, Nature Communications.

IgG-Mediated Systemic Anaphylaxis Lyn but Not Fyn Kinase Controls

Bernice, S. Spiegel, F. Finkelman, 2012 .

Ceramide 1-Phosphate, a Mediator of Phagocytosis*

S. Spiegel, H. Petty, J. Shayman, 2005, Journal of Biological Chemistry.

Involvement of sphingolipids metabolites in cellular proliferation modulated by ganglioside GM1

S. Spiegel, A. Olivera, N. E. Buckley, 1996, Glycoconjugate Journal.

Differential effects of sphingomyelinase and cell-permeable ceramide analogs on proliferation of Swiss 3T3 fibroblasts.

S. Spiegel, C. Rani, A. Olivera, 1997, Biochimica et biophysica acta.

Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin–sensitive mechanism in murine and human hepatocytes

S. Spiegel, P. Dent, Clint Mitchell, 2005, Hepatology.

Cautionary note on the use of the B subunit of cholera toxin as a ganglioside GM1 probe: Detection of cholera toxin A subunit in B subunit preparations by a sensitive adenylate cyclase assay

S. Spiegel, 1990, Journal of cellular biochemistry.

Insertion of ganglioside GM1 into rat glioma C6 cells renders them susceptible to growth inhibition by the B subunit of cholera toxin.

S. Spiegel, 1988, Biochimica et biophysica acta.

Fenretinide Causes Emphysema, Which Is Prevented by Sphingosine 1-Phoshate

S. Spiegel, N. Voelkel, J. Allegood, 2013, PloS one.

Roles of sphingosine-1-phosphate in cell growth, differentiation, and death.

S. Spiegel, O. Cuvillier, A. Olivera, 1998, Biochemistry. Biokhimiia.

Sphingosine 1-phosphate stimulates rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts.

S. Spiegel, Fang Wang, C. Nobes, 1997, The Biochemical journal.

Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma

S. Spiegel, N. Voelkel, 2009, Immunology and cell biology.

Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis.

S. Spiegel, K. Takabe, R. Ramanathan, 2016, The Journal of surgical research.

Export and functions of sphingosine-1-phosphate.

S. Milstien, S. Spiegel, K. Takabe, 2009, Biochimica et biophysica acta.

Role of ABCC1 in export of sphingosine-1-phosphate from mast cells

S. Payne, S. Milstien, S. Spiegel, 2006, Proceedings of the National Academy of Sciences.

Involvement of gangliosides in lymphocyte stimulation.

M. Wilchek, S. Spiegel, A. Ravid, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Possible involvement of a GTP-binding protein in a late event during endogenous ganglioside-modulated cellular proliferation.

S. Spiegel, 1989, The Journal of biological chemistry.

therapeutic targets in human leukemia A selective sphingosine kinase 1 inhibitor integrates multiple molecular

Barbara S. Paugh, S. Milstien, S. Spiegel, 2013 .

Sphingosine-1-phosphate in the lymphatic fluid determined by novel methods

S. Spiegel, T. Wakai, K. Takabe, 2016, Heliyon.

Murine model of long-term obstructive jaundice.

S. Spiegel, K. Takabe, Huiping Zhou, 2016, The Journal of surgical research.

Uncleaved ApoM Signal Peptide Is Required for Formation of Large ApoM/Sphingosine 1-Phosphate (S1P)-enriched HDL Particles*

S. Spiegel, Dongmei Cheng, A. Gebre, 2015, The Journal of Biological Chemistry.

Ganglioside GM1 and sphingolipid breakdown products in cellular proliferation and signal transduction pathways.

S. Spiegel, A. Olivera, 1992, Glycoconjugate journal.

A Serotype 5/3 Adenovirus Expressing MDA-7/IL-24 Infects Renal Carcinoma Cells and Promotes Toxicity of Agents That Increase Ros and Ceramide Levels

P. Fisher, S. Spiegel, P. Dent, 2011, Molecular Pharmacology.

The role of sphingosine-1-phosphate and its receptors in asthma.

S. Spiegel, J. Ryan, 2008, Drug news & perspectives.

Sphingosine 1‐phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma

S. Spiegel, S. Peters, A. Ammit, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A2 independently of sphingosine-1-phosphate receptors The immunosuppressant drug FTY720 inhibits cytosolic phospholipase

S. Payne, S. Milstien, S. Spiegel, 2013 .

Essential roles of sphingosine-1–phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema

S. Milstien, S. Spiegel, J. Ryan, 2010, The Journal of experimental medicine.

Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions.

S. Milstien, S. Spiegel, Sergio E Alvarez, 2008, Blood.

The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors.

S. Payne, S. Milstien, S. Spiegel, 2007, Blood.

Sphingosine‐1‐phosphate stimulates contraction of human airway smooth muscle cells

S. Spiegel, H. Rosenfeldt, R. Panettieri, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The roles of sphingosine-1-phosphate in asthma.

S. Milstien, S. Spiegel, H. Rosenfeldt, 2002, Molecular immunology.

Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6.

J. P. Hobson, S. Spiegel, M. Lipp, 2000, Blood.

Involvement of focal adhesion kinase in inhibition of motility of human breast cancer cells by sphingosine 1-phosphate.

S. Spiegel, Fang Wang, A. Olivera, 1999, Experimental cell research.

Involvement of a Pertussis Toxin-sensitive G Protein in the Mitogenic Signaling Pathways of Sphingosine 1-Phosphate (*)

S. Spiegel, Kimberly A. Goodemote, M. Mattie, 1995, The Journal of Biological Chemistry.

Ormdl3 and Allergic Asthma: from Physiology to Pathology.

S. Milstien, S. Spiegel, Briana James, 2019, The Journal of allergy and clinical immunology.

Role of sphingosine kinase 1 and sphingosine‐1‐phosphate in CD40 signaling and IgE class switching

Eugene Y. Kim, M. Maceyka, S. Milstien, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells.

E. Gelmann, S. Milstien, S. Spiegel, 2000, Cancer research.

Tumor necrosis factor-alpha sensitizes prostate cancer cells to gamma-irradiation-induced apoptosis.

E. Gelmann, S. Spiegel, C. Bowen, 1999, Cancer research.

Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation.

S. Spiegel, A. Olivera, H. Zhang, 1992, The Journal of biological chemistry.

Uncleaved apoM signal peptide is required for formation of large apoM/S1P-enriched HDL particles ‡

S. Spiegel, Dongmei Cheng, A. Gebre, 2015 .

Regulatory role of SphK1 in TLR7/9‐dependent type I interferon response and autoimmunity

Abhirup Ghosh, S. Saha, S. Spiegel, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.

S. Spiegel, N. E. Buckley, H. Zhang, 1990, The Journal of biological chemistry.

Sphingosine kinase 1 mediates sexual dimorphism in fibrosis in a mouse model of NASH

S. Spiegel, J. Allegood, L. Cowart, 2022, Molecular metabolism.

Recycling of Sphingosine Is Regulated by the Concerted Actions of Sphingosine-1-phosphate Phosphohydrolase 1 and Sphingosine Kinase 2*

M. Maceyka, S. Milstien, S. Spiegel, 2007, Journal of Biological Chemistry.

Sphingosine kinases: a novel family of lipid kinases.

M. Maceyka, S. Milstien, S. Spiegel, 2002, Progress in nucleic acid research and molecular biology.

IL-4 and TGF-β1 Counterbalance One Another while Regulating Mast Cell Homeostasis

S. Spiegel, D. Conrad, J. Ryan, 2010, The Journal of Immunology.

This information is current as Homeostasis Another while Regulating Mast Cell 1 Counterbalance One β IL-4 and

S. Spiegel, J. Ryan, Nitin K. Yerram, 2010 .

VEGF potentiates GD 3-mediated immune suppression by human ovarian cancer cells

S. Spiegel, S. Temkin, S. Goldblum, 2016 .

Divergence in Regulation of Nitric-oxide Synthase and Its Cofactor Tetrahydrobiopterin by Tumor Necrosis Factor-α

S. Milstien, S. Spiegel, L. Vann, 2000, The Journal of Biological Chemistry.

Identification of Direct Intracellular Targets of Sphingosine 1‐Phosphate (S1P)

S. Milstien, S. Spiegel, N. Hait, 2013 .

Sphingosine-1-phosphate receptor 1 activation in the central nervous system drives cisplatin-induced cognitive impairment

S. Cuzzocrea, S. Spiegel, E. Esposito, 2022, The Journal of clinical investigation.

Ceramide Kinase Mediates Cytokine- and Calcium Ionophore-induced Arachidonic Acid Release*

A. Bielawska, Y. Hannun, S. Spiegel, 2003, Journal of Biological Chemistry.

Involvement of Sphingosine Kinase in TNF-α-stimulated Tetrahydrobiopterin Biosynthesis in C6 Glioma Cells*

S. Payne, S. Milstien, S. Spiegel, 2002, The Journal of Biological Chemistry.

Genotype-Dependent Effects of TGF-

G. Bandara, S. Spiegel, D. Conrad, 2013 .

Tumor Necrosis Factor-a Sensitizes Prostate Cancer Cells to g-Irradiation-induced Apoptosis 1

E. Gelmann, S. Spiegel, C. Bowen, 1999 .

Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response.

J. Broach, S. Spiegel, J. Nickels, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Sphingosine kinases regulate ER contacts with late endocytic organelles and cholesterol trafficking

S. Milstien, S. Spiegel, D. Ford, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Fidelity of translesional synthesis past benzo[a]pyrene diol epoxide-2'-deoxyguanosine DNA adducts: marked effects of host cell, sequence context, and chirality.

S. Spiegel, S. Amin, N. Geacintov, 1996, Biochemistry.

Sphingosine-1-Phosphate - A New Lipid Signaling Molecule

S. Spiegel, O. Cuvillier, A. Olivera, 1996 .

Sphingosine‐1‐phosphate induces development of functionally mature chymase‐expressing human mast cells from hematopoietic progenitors

S. Milstien, S. Spiegel, D. Kapitonov, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Functions of the Multifaceted Family of Sphingosine Kinases and Some Close Relatives*

S. Milstien, S. Spiegel, 2007, Journal of Biological Chemistry.

Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression

S. Spiegel, J. Eberle, M. Bektas, 2005, Oncogene.

Elevated cyclic AMP suppresses ConA-induced MT1-MMP expression in MDA-MB-231 human breast cancer cells

S. Spiegel, Hiroshi Sato, M. Seiki, 1998, Clinical & Experimental Metastasis.

Transmembrane signaling by the B subunit of cholera toxin: increased cytoplasmic free calcium in rat lymphocytes

S. Grinstein, S. Dixon, S. Spiegel, 1987, The Journal of cell biology.

Gangliosides as bimodal regulators of cell growth.

S. Spiegel, P. Fishman, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1‐dependent upregulation of sphingosine kinase 1 transcription

S. Milstien, S. Spiegel, X. Fang, 2010, FEBS letters.

Sphingosine, a Breakdown Product of Cellular Sphingolipids, in Cellular Proliferation and Phospholipid Metabolism

S. Spiegel, 1993 .

Radiation-induced apoptosis mediated by retinoblastoma protein.

E. Gelmann, S. Spiegel, C. Bowen, 1998, Cancer research.

Radiation-induced Apoptosis Mediated by KetiIK Â»blastoma Protein1

E. Gelmann, S. Spiegel, C. Bowen, 1998 .

Functions of a new family of sphingosine-1-phosphate receptors.

S. Milstien, S. Spiegel, 2000, Biochimica et biophysica acta.

Sphingosine 1-phosphate as a therapeutic agent

S. Spiegel, R. Kolesnick, 2002, Leukemia.

Ceramide Kinase, a Novel Lipid Kinase

S. Spiegel, Hong Liu, Tetsuya Shimizugawa, 2002, The Journal of Biological Chemistry.

Role of Sphingosine-1-phosphate Phosphatase 1 in Epidermal Growth Factor-induced Chemotaxis*

J. P. Hobson, S. Milstien, S. Spiegel, 2004, Journal of Biological Chemistry.

Lysophospholipid ( S 1 P ) receptors ( version 2019 . 4 ) in the IUPHAR / BPS Guide to Pharmacology Database

S. Spiegel, J. Chun, V. Blaho, 2019 .

Lysophospholipid Receptors in the Nervous System

S. Spiegel, R. Toman, 2002, Neurochemical Research.

Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor.

S. Spiegel, A. Porcelli, M. Rugolo, 2000, Archives of biochemistry and biophysics.

Sphingosine-1-phosphate and lipid phosphohydrolases.

S. Milstien, S. Spiegel, Hong Liu, 2002, Biochimica et biophysica acta.

Modified breast cancer model for preclinical immunotherapy studies.

S. Spiegel, H. Bear, K. Takabe, 2016, The Journal of surgical research.

Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quiescent Swiss 3T3 fibroblasts.

S. Spiegel, A. Olivera, N. E. Buckley, 1992, The Journal of biological chemistry.

The Immunomodulator FTY720 Has a Direct Cytoprotective Effect in Oligodendrocyte Progenitors

S. Payne, S. Spiegel, C. Sato-Bigbee, 2007, Journal of Pharmacology and Experimental Therapeutics.

Sphingosine kinase 1

S. Spiegel, S. Paugh, D. Kapitonov, 2007 .

Sphingosine 1‐Phosphate: A Ligand for the EDG‐1 Family of G‐Protein‐Coupled Receptors

S. Spiegel, 2000, Annals of the New York Academy of Sciences.

Estradiol Induces Export of Sphingosine 1-Phosphate from Breast Cancer Cells via ABCC1 and ABCG2*

Sarah Spiegel, Kazuaki Takabe, S. Milstien, 2010, The Journal of Biological Chemistry.

Sphingosine-1-phosphate: From insipid lipid to a key regulator

S. Spiegel, 2020, The Journal of Biological Chemistry.

Sphingosine kinase 1 in breast cancer.

S. Spiegel, K. Geffken, 2017, Advances in biological regulation.

Targeting sphingosine-1-phosphate in hematologic malignancies.

S. Milstien, S. Spiegel, K. Takabe, 2011, Anti-cancer agents in medicinal chemistry.

Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin.

S. Milstien, S. Spiegel, P. Dent, 2007, Cancer research.

A rapid and sensitive method to measure secretion of sphingosine-1-phosphate.

S. Payne, S. Milstien, S. Spiegel, 2007, Methods in enzymology.

Sphingosine-1-phosphate: an enigmatic signalling lipid

Sarah Spiegel, S. Milstien, S. Spiegel, 2003, Nature Reviews Molecular Cell Biology.

New insights into functions of the sphingosine-1-phosphate transporter SPNS2

M. Maceyka, S. Milstien, S. Spiegel, 2019, Journal of Lipid Research.

Role of Sphingosine-1-Phosphate Phosphohydrolase 1 in the Regulation of Resistance Artery Tone

S. Spiegel, H. Bolz, S. Heximer, 2008, Circulation research.

Sphingosine‐1‐phosphate and the immunosuppressant, FTY720‐phosphate, regulate detrusor muscle tone

S. Payne, S. Milstien, S. Spiegel, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Sphingosine and Its Analog, the Immunosuppressant 2-Amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, Interact with the CB1 Cannabinoid Receptor

S. Milstien, S. Spiegel, D. Selley, 2006, Molecular Pharmacology.

Effect of a membrane-targeted sphingosine kinase 1 on cell proliferation and survival.

S. Payne, S. Spiegel, S. Summers, 2005, The Biochemical journal.

The sphingosine-1-phosphate receptor EDG-1 is essential for platelet-derived growth factor-induced cell motility.

J. P. Hobson, S. Milstien, S. Spiegel, 2001, Biochemical Society transactions.

Memo Has a Novel Role in S1P Signaling and Crucial for Vascular Development

C. Genoud, S. Spiegel, F. Maurer, 2014, PloS one.

ORMDL proteins regulate ceramide levels during sterile inflammation

M. Maceyka, S. Milstien, S. Spiegel, 2016, Journal of Lipid Research.

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

Cheng Luo, Sarah Spiegel, Ronen Marmorstein, 2009, Science.

- 14-1-0086 TITLE : Targeting the S 1 P Axis and Development of a Novel Therapy for Obesity-Related Triple-Negative Breast Cancer

S. Spiegel, 2017 .

Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole‐body energy expenditure

Anneliese O. Speak, N. Karp, C. Lelliott, 2016, The Journal of pathology.

Fluorescent reagents for the labeling of glycoconjugates in solution and on cell surfaces.

M. Wilchek, S. Spiegel, Y. Spiegel, 1980, Biochemical and biophysical research communications.

Glycosphingolipid composition of MDA-MB-231 and MCF-7 human breast cancer cell lines

S. Spiegel, F. Wang, K. Nohara, 1998, Breast Cancer Research and Treatment.

Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells

S. Milstien, S. Spiegel, O. Cuvillier, 2001, Cell Death and Differentiation.

Genotype-Dependent Effects of TGF-β1 on Mast Cell Function: Targeting the Stat5 Pathway

G. Bandara, S. Spiegel, D. Conrad, 2013, The Journal of Immunology.

Preclinical models of non-alcoholic steatohepatitis leading to hepatocellular carcinoma.

S. Spiegel, C. Green, 2022, Advances in biological regulation.

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

Cheng Luo, Sarah Spiegel, Junyan Lu, 2014, Nature Neuroscience.

Fingolimod augments Pemetrexed killing of non-small cell lung cancer and overcomes resistance to ERBB inhibition

S. Spiegel, P. Dent, L. Booth, 2018, Cancer biology & therapy.

Depolarisation induces rapid and transient formation of intracellular sphingosine‐1‐phosphate

K. Jakobs, S. Spiegel, B. Kleuser, 2001, FEBS letters.

Sphingosine kinase: a mediator of vital cellular functions.

S. Spiegel, A. Olivera, 2001, Prostaglandins & other lipid mediators.

Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents

S. Spiegel, M. Hutchinson, D. Salvemini, 2020, Journal of Neuroinflammation.

Sphingosine kinase from Swiss 3T3 fibroblasts: a convenient assay for the measurement of intracellular levels of free sphingoid bases.

S. Spiegel, A. Olivera, J. Rosenthal, 1994, Analytical biochemistry.

Stereospecificity of sphingosine-induced intracellular calcium mobilization and cellular proliferation.

S. Spiegel, A. Olivera, R. Schmidt, 1994, The Journal of biological chemistry.

Glycosphingolipids of rat T cells. Predominance of asialo-GM1 and GD1c.

H. Nakauchi, S. Spiegel, K. Nohara, 1994, Biochemistry.

Interaction of the B subunit of cholera toxin with endogenous ganglioside GM1 causes changes in membrane potential of rat thymocytes

S. Spiegel, P. Fishman, Dally A. Mulhern, 1989, The Journal of Membrane Biology.

Fibrillar organization of fibronectin is expressed coordinately with cell surface gangliosides in a variant murine fibroblast

S. Spiegel, J. Moss, K. Yamada, 1986, The Journal of cell biology.

Sphingosine Kinase Modulates Microvascular Tone and Myogenic Responses Through Activation of RhoA/Rho Kinase

S. Spiegel, S. Bolz, C. Boer, 2003, Circulation.

Synthesis of erythro-ω-aminosphingosine and preparation of an affinity column for sphingosine kinase purification

S. Spiegel, A. Kozikowski, Ding Qingjie, 1996 .

Direct evidence that endogenous GM1 ganglioside can mediate thymocyte proliferation.

S. Spiegel, P. Fishman, R. Weber, 1985, Science.

The S1P/S1PR2 axis regulates early airway T cell infiltration in murine mast cell-dependent acute allergic responses

S. Milstien, S. Spiegel, J. Ryan, 2015 .

Incorporation of fluorescent gangliosides into human fibroblasts: mobility, fate, and interaction with fibronectin

S. Spiegel, J. Schlessinger, P. Fishman, 1984, The Journal of cell biology.

Sphingosine-1-phosphate signaling and its role in disease.

Sarah Spiegel, M. Maceyka, S. Milstien, 2012, Trends in cell biology.

Sphingosine kinase: a closer look at last.

S. Spiegel, Santiago Lima, 2013, Structure.

Assaying sphingosine kinase activity.

S. Spiegel, A. Olivera, K. Barlow, 2000, Methods in Enzymology.

Ceramide plays a prominent role in MDA‐7/IL‐24‐induced cancer‐specific apoptosis

P. Fisher, S. Spiegel, P. Dent, 2009, Journal of cellular physiology.

Extracellular and intracellular actions of sphingosine-1-phosphate.

M. Maceyka, S. Milstien, S. Spiegel, 2010, Advances in experimental medicine and biology.

Enzymatic method for measurement of sphingosine 1-phosphate.

S. Milstien, S. Spiegel, L. Edsall, 2000, Methods in enzymology.

Sphingosine kinase. Assay and product analysis.

S. Spiegel, A. Olivera, 1998, Methods in molecular biology.

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

S. Spiegel, J. Gutkind, G. Pirianov, 1996, Nature.

Design of new quinolin-2-one-pyrimidine hybrids as sphingosine kinases inhibitors.

S. Spiegel, S. Andujar, R. Enriz, 2019, Bioorganic chemistry.

A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells

S. Payne, S. Milstien, S. Spiegel, 2005, The Journal of cell biology.

Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts

S. Spiegel, G. Brooker, A. Olivera, 1993, The Journal of cell biology.

Functional analysis of molecular and pharmacological modulators of mitochondrial fatty acid oxidation

S. Spiegel, X. Fang, Huiping Zhou, 2020, Scientific Reports.

Novel Sphingolipid‐Based Cancer Therapeutics in the Personalized Medicine Era: CHAPTER TWELVE

Sarah Spiegel, Mark Kester, S. Spiegel, 2018, Advances in cancer research.

Non-alcoholic fatty liver disease: Insights from sphingolipidomics.

S. Spiegel, J. Allegood, L. Cowart, 2018, Biochemical and biophysical research communications.

Neuropeptide Y induces migration , proliferation , and tube formation of endothelial cells bimodally via Y 1 , Y 2 , and Y 5 receptors

J. P. Hobson, S. Spiegel, H. Kleinman, 2006 .

A novel approach for the topographical localization of glycolipids on the cell surface.

M. Wilchek, S. Spiegel, E. Bayer, 1982, Biochimica et biophysica acta.

Sphingolipid metabolites in inflammatory disease

Sarah Spiegel, S. Spiegel, Michael Maceyka, 2014, Nature.

Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy

S. Milstien, S. Spiegel, S. Grant, 2012, Oncogene.

Sphingolipid metabolites: Members of a new class of lipid second messengers

S. Milstien, S. Spiegel, 1995, The Journal of Membrane Biology.

Recognition deficits in mice carrying mutations of genes encoding BLOC‐1 subunits pallidin or dysbindin

J. Jentsch, S. Spiegel, K. Karlsgodt, 2015, Genes, brain, and behavior.

Tumor‐derived exosomes (TDEs): How to avoid the sting in the tail

Christopher J. Lyon, S. Spiegel, Tony Y. Hu, 2019, Medicinal research reviews.

Glycosphingolipids and cell death

S. Spiegel, M. Bektas, 2003, Glycoconjugate Journal.

The role of sphingosine in cell growth regulation and transmembrane signaling.

S. Spiegel, A. Olivera, R. Carlson, 1993, Advances in lipid research.

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

S. Spiegel, A. Olivera, 1993, Nature.

Sphingolipid metabolism and cell growth regulation

S. Spiegel, A. Merrill, 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

S. Spiegel, T. Hla, O. Cuvillier, 1998, The Journal of cell biology.

Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.

C. H. Liu, S. Spiegel, T. Hla, 1998, Science.

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation

S. Spiegel, G. Brooker, A. Olivera, 1991, The Journal of cell biology.

Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling Supported by National Institutes of Health Grants R37GM043880, RO1CA61774, RO1AI050094, and U19AI077435-018690 (SS) and the NIMH Intramural Research Program (SM). Published, JLR Papers in Press, November 5, 2008.

Sarah Spiegel, S. Milstien, S. Spiegel, 2009, Journal of Lipid Research.

“Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

S. Milstien, S. Spiegel, S. Paugh, 2008, Pharmacological Reviews.

The bimodal growth response of Swiss 3T3 cells to the B subunit of cholera toxin is independent of the density of its receptor, ganglioside GM1.

S. Spiegel, G. Matyas, N. E. Buckley, 1990, Experimental cell research.

Interaction of ganglioside GM1 with the B subunit of cholera toxin modulates growth and differentiation of neuroblastoma N18 cells

S. Spiegel, V. Walle, D. Mascó, 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Role of Lysophospholipids in Cell Growth and Survival

S. Spiegel, X. Fang, Xianjun Fang, 2007 .

Fluorescent gangliosides as probes for the retention and organization of fibronectin by ganglioside-deficient mouse cells

S. Spiegel, J. Moss, K. Yamada, 1985, The Journal of cell biology.

Mitogenesis of 3T3 fibroblasts induced by endogenous ganglioside is not mediated by cAMP, protein kinase C, or phosphoinositides turnover.

S. Spiegel, C. Panagiotopoulos, 1988, Experimental cell research.

Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase.

P. Herdewijn, S. van Calenbergh, R. Busson, 1999, Bioorganic & medicinal chemistry letters.

Structure—Activity Relationship of Short-Chain Sphingoid Bases as Inhibitors of Sphingosine Kinase.

P. Herdewijn, R. Busson, S. Spiegel, 2000 .

Sphingosine 1-Phosphate-induced Cell Rounding and Neurite Retraction Are Mediated by the G Protein-coupled Receptor H218*

S. Spiegel, R. Schmidt, J. V. Van Brocklyn, 1999, The Journal of Biological Chemistry.

Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase*

S. Spiegel, A. Olivera, T. Kohama, 1998, The Journal of Biological Chemistry.

N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide.

S. Spiegel, O. Cuvillier, B. Kleuser, 1998, Biochemistry.

Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation

S. Spiegel, G. Pirianov, L. Edsall, 1997, The Journal of Neuroscience.

Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.

S. Spiegel, G. Brooker, M. Mattie, 1994, The Journal of biological chemistry.

Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species.

S. Payne, S. Spiegel, P. Dent, 2005, Cancer research.

Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation

P. Fisher, S. Spiegel, K. Ryan, 2008, Cancer biology & therapy.

Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond

S. Milstien, S. Spiegel, Gregory T Kunkel, 2013, Nature Reviews Drug Discovery.

Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform*

S. Milstien, S. Spiegel, Hong Liu, 2000, The Journal of Biological Chemistry.

Purification and Characterization of Rat Kidney Sphingosine Kinase*

S. Milstien, S. Spiegel, A. Olivera, 1998, The Journal of Biological Chemistry.

SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism*

M. Zhang, S. Milstien, S. Spiegel, 2005, Journal of Biological Chemistry.

Targeting SphK1 as a new strategy against cancer.

S. Milstien, S. Spiegel, D. Kapitonov, 2008, Current drug targets.

Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking*

S. Milstien, S. Spiegel, Santiago Lima, 2017, The Journal of Biological Chemistry.

Essential Role for Sphingosine Kinases in Neural and Vascular Development

R. Proia, S. Spiegel, A. Olivera, 2005, Molecular and Cellular Biology.

Interleukin-1 Regulates the Expression of Sphingosine Kinase 1 in Glioblastoma Cells*

Sarah Spiegel, Barbara S. Paugh, Steven W. Paugh, 2009, Journal of Biological Chemistry.

Sphingosine Kinases and Sphingosine-1-Phosphate Are Critical for Transforming Growth Factor β-Induced Extracellular Signal-Regulated Kinase 1 and 2 Activation and Promotion of Migration and Invasion of Esophageal Cancer Cells

S. Spiegel, Sergio E Alvarez, Sergio E. Alvarez, 2008, Molecular and Cellular Biology.

Invasion of Esophageal Cancer Cells 2 Activation and Promotion of Migration andExtracellular Signal-Regulated Kinase 1-Induced β Transforming Growth Factor Sphingosine-1-Phosphate Are Critical for Sphingosine Kinases and

S. Spiegel, Sergio E Alvarez, Sergio E. Alvarez, 2008 .

Sphingolipid Metabolites in Signal Transduction

S. Milstien, S. Spiegel, 2000 .

Sphingosine 1-Phosphate Inhibits Activation of Caspases that Cleave Poly(ADP-ribose) Polymerase and Lamins during Fas- and Ceramide-mediated Apoptosis in Jurkat T Lymphocytes*

S. Spiegel, D. Rosenthal, M. Smulson, 1998, The Journal of Biological Chemistry.

Sphingosine-1-phosphate Signalling drives an Angiogenic Transcriptional Programme in Diffuse Large B Cell Lymphoma

M. Care, S. Spiegel, G. Reynolds, 2019, Leukemia.

Sphingosine-1-Phosphate: Member of a New Class of Lipid Second Messengers

S. Milstien, S. Spiegel, O. Cuvillier, 1997 .

Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian cancer

S. Spiegel, Huanjie Shao, X. Fang, 2015, Oncotarget.

SPHINGOSINE-1-PHOSPHATE: A MISSING COFACTOR FOR THE E3 UBIQUITIN LIGASE TRAF2

Cheng Luo, Sarah Spiegel, Hualiang Jiang, 2010, Nature.

Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.

J. P. Hobson, C. H. Liu, C. Deng, 2000, The Journal of clinical investigation.

Sphingosine-1-phosphate, a novel second messenger involved in cell growth regulation and signal transduction, affects growth and invasiveness of human breast cancer cells

S. Spiegel, A. Olivera, E. Thompson, 2004, Breast Cancer Research and Treatment.

Dye-free spectrophotometric measurement of nucleic acid-to-protein ratio for cell-selective extracellular vesicle discrimination.

Christopher J. Lyon, S. Spiegel, Tony Y. Hu, 2021, Biosensors & bioelectronics.

Is tail vein injection a relevant breast cancer lung metastasis model?

S. Milstien, S. Spiegel, K. Takabe, 2013, Journal of thoracic disease.

Functional characterization of human sphingosine kinase‐1

S. Milstien, S. Spiegel, Hong Liu, 2000, FEBS letters.

EDG‐1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration

J. P. Hobson, S. Milstien, S. Spiegel, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis.

K. Sakimura, S. Milstien, S. Spiegel, 2018, Cancer research.

Cloning and Characterization of a Protein Kinase A Anchoring Protein (AKAP)-related Protein That Interacts with and Regulates Sphingosine Kinase 1 Activity*

S. Milstien, S. Spiegel, E. Lacaná, 2002, The Journal of Biological Chemistry.

Sphingosine 1-phosphate signaling: providing cells with a sense of direction.

S. Milstien, S. Spiegel, D. English, 2002, Trends in cell biology.

Characterization of Murine Sphingosine-1-phosphate Phosphohydrolase*

S. Milstien, S. Spiegel, H. Le Stunff, 2002, The Journal of Biological Chemistry.

Sphingosine‐1‐phosphate: signaling inside and out

S. Milstien, S. Spiegel, 2000, FEBS letters.

Involvement of Sphingosine in Mitochondria-dependent Fas-induced Apoptosis of Type II Jurkat T Cells*

S. Spiegel, O. Cuvillier, L. Edsall, 2000, The Journal of Biological Chemistry.

Sphingosine 1-Phosphate Stimulates Cell Migration through a Gi-coupled Cell Surface Receptor

J. P. Hobson, S. Milstien, S. Spiegel, 1999, The Journal of Biological Chemistry.

Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival

S. Spiegel, O. Cuvillier, A. Olivera, 1999, The Journal of cell biology.

Signal transduction through lipid second messengers.

S. Spiegel, R. Kolesnick, D. A. Foster, 1996, Current opinion in cell biology.

TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition

S. Milstien, S. Spiegel, P. Dent, 2018, Autophagy.

An improved syngeneic orthotopic murine model of human breast cancer progression

S. Milstien, S. Spiegel, K. Takabe, 2014, Breast Cancer Research and Treatment.

Resection of the primary tumor improves survival in metastatic breast cancer by reducing overall tumor burden.

S. Spiegel, H. Bear, K. Takabe, 2013, Surgery.

Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain

G. Bennett, S. Spiegel, J. Lionberger, 2018, The Journal of experimental medicine.

Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway.

P. Fisher, S. Spiegel, D. Häussinger, 2010, Cancer research.

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

Edward Ryder, David J. Adams, Louise van der Weyden, 2017, Nature.

The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide.

P. Atadja, S. Payne, S. Spiegel, 2006, Molecular pharmacology.

Sphingosine kinase 1 is required for migration, proliferation and survival of MCF‐7 human breast cancer cells

S. Milstien, S. Spiegel, H. Sankala, 2005, FEBS letters.

Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis

S. Milstien, S. Spiegel, I. Galve-Roperh, 2002, The Journal of cell biology.

Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1.

C. H. Liu, S. Spiegel, T. Hla, 1999, Molecular biology of the cell.

Lysophospholipid receptor nomenclature review: IUPHAR Review 8

S. Spiegel, J. Chun, Y. Kihara, 2014, British journal of pharmacology.

The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer

S. Milstien, S. Spiegel, D. Leroith, 2015, Oncogenesis.

Cancer and Inflammation

S. Spiegel, K. Takabe, A. Yamada, 2016 .

Sphingosine‐1‐phosphate receptors mediate neuromodulatory functions in the CNS

S. Milstien, S. Spiegel, D. Selley, 2009, Journal of neurochemistry.

Divergence in Signal Transduction Pathways of Platelet-derived Growth Factor (PDGF) and Epidermal Growth Factor (EGF) Receptors

S. Spiegel, Jie Wu, Fang Wang, 1997, The Journal of Biological Chemistry.

KSR stimulates Raf-1 activity in a kinase-independent manner.

K., G. Rubin, D. Morrison, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy

Junlin Qi, H. Ruohola-Baker, S. Spiegel, 2013, Disease Models & Mechanisms.

Novel role of sphingosine kinase 1 as a mediator of neurotrophin‐3 action in oligodendrocyte progenitors

S. Spiegel, C. Sato-Bigbee, S. Goparaju, 2005, Journal of neurochemistry.

Sphingosine-1-phosphate and estrogen signaling in breast cancer.

S. Milstien, S. Spiegel, Melissa A. Maczis, 2016, Advances in biological regulation.

Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases.

S. Milstien, S. Spiegel, S. Paugh, 2006, Biochimica et biophysica acta.

Autophagy Induced by Deficiency of Sphingosine-1-phosphate Phosphohydrolase 1 Is Switched to Apoptosis by Calpain-mediated Autophagy-related Gene 5 (Atg5) Cleavage*

S. Milstien, S. Spiegel, J. Allegood, 2011, The Journal of Biological Chemistry.

Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy.

S. Spiegel, Santiago Lima, J. Newton, 2015, Experimental cell research.

Filamin A Links Sphingosine Kinase 1 and Sphingosine-1-Phosphate Receptor 1 at Lamellipodia To Orchestrate Cell Migration

S. Milstien, S. Spiegel, Sergio E Alvarez, 2008, Molecular and Cellular Biology.

Sphingosine 1-Phosphate, Present in Serum-derived Lipoproteins, Activates Matriptase*

Chen-Yong Lin, Sarah Spiegel, J. P. Hobson, 2002, The Journal of Biological Chemistry.

Lyn but Not Fyn Kinase Controls IgG-Mediated Systemic Anaphylaxis

S. Spiegel, F. Finkelman, D. Conrad, 2012, The Journal of Immunology.

Function of Gangliosides in Cellular Proliferation

S. Spiegel, 2020 .

Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics

S. Spiegel, K. Harikumar, X. Fang, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling

S. Spiegel, P. Dent, S. Grant, 2012, Cancer biology & therapy.

Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells

S. Milstien, S. Spiegel, O. Cuvillier, 2001, Journal of neurochemistry.

Functional analysis of molecular and pharmacological modulators of mitochondrial fatty acid oxidation

S. Spiegel, X. Fang, Huiping Zhou, 2020, Scientific Reports.

CERAMIDE IN APOPTOSIS AND OXIDATIVE STRESS IN ALLERGIC INFLAMMATION AND ASTHMA.

S. Milstien, S. Spiegel, S. Wenzel, 2020, The Journal of allergy and clinical immunology.

CRISPR/Cas9 deletion of ORMDLs reveals complexity in sphingolipid metabolism

S. Spiegel, B. Wattenberg, C. Green, 2021, Journal of lipid research.

Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells

Matthew R. MacDougall, S. Morad, M. Cabot, 2019, Journal of Lipid Research.

Neuronal contact upregulates astrocytic sphingosine‐1‐phosphate receptor 1 to coordinate astrocyte‐neuron cross communication

S. Spiegel, T. Kordula, S. Singh, 2021, Glia.

Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network

Sarah Spiegel, Kazuaki Takabe, S. Milstien, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Neutrophilia in severe asthma is reduced in Ormdl3 overexpressing mice

R. Proia, S. Milstien, S. Spiegel, 2023, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling.

Sarah Spiegel, S. Spiegel, Deborah A Lebman, 2008, Journal of lipid research.

MDA-7/IL-24–induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK–dependent mechanism

P. Fisher, S. Spiegel, P. Dent, 2009, Molecular Cancer Therapeutics.

OSU-03012 Stimulates PKR-Like Endoplasmic Reticulum-Dependent Increases in 70-kDa Heat Shock Protein Expression, Attenuating Its Lethal Actions in Transformed Cells

P. Fisher, S. Spiegel, P. Dent, 2008, Molecular Pharmacology.

Endogenous ganglioside GM1 modulates L-type calcium channel activity in N18 neuroblastoma cells

S. Spiegel, G. Brooker, D. Mascó, 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Sphingosine‐1‐phosphate: dual messenger functions

S. Payne, S. Milstien, S. Spiegel, 2002, FEBS letters.

ABCC1-Exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1, Shortens Survival of Mice and Patients with Breast Cancer

I. Endo, T. Ishikawa, S. Milstien, 2018, Molecular Cancer Research.

Nrg-1 Belongs to the Endothelial Differentiation Gene Family of G Protein-coupled Sphingosine-1-phosphate Receptors*

Sylvia Wong, S. Milstien, S. Spiegel, 2001, The Journal of Biological Chemistry.

A chicken-or-egg conundrum in apoptosis: which comes first? Ceramide or PKCdelta?

S. Spiegel, S. Grant, 2002, The Journal of clinical investigation.

MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts.

S. Spiegel, P. Burbelo, W. Bahou, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Sphingosine Kinase Type 1 Induces G12/13-mediated Stress Fiber Formation, yet Promotes Growth and Survival Independent of G Protein-coupled Receptors*

S. Milstien, S. Spiegel, J. Chun, 2003, Journal of Biological Chemistry.

Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility

J. P. Hobson, M. Caron, S. Milstien, 2001, Science.

International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid Receptor Nomenclature

Sarah Spiegel, Kevin R. Lynch, S. Spiegel, 2010, Pharmacological Reviews.

Sphingosine-1-Phosphate Receptors

S. Spiegel, Michael Maceyka, 2003 .

CHAPTER 163 – Sphingosine-1-Phosphate Receptors

S. Spiegel, Michael Maceyka, Sarah Spiegel, 2003 .

The S1P2 Receptor Negatively Regulates Platelet-Derived Growth Factor-Induced Motility and Proliferation

S. Milstien, S. Spiegel, J. Chun, 2005, Molecular and Cellular Biology.

The role of sphingosine-1-phosphate in smooth muscle contraction.

S. Spiegel, K. Watterson, P. Ratz, 2005, Cellular signalling.

Generation and metabolism of bioactive sphingosine‐1‐phosphate

Sarah Spiegel, S. Milstien, S. Spiegel, 2004, Journal of cellular biochemistry.

Modulation of adpative immune responses by sphingosine-1-phosphate

S. Payne, S. Milstien, S. Spiegel, 2004 .

Role of ceramide in mediating apoptosis of irradiated LNCaP prostate cancer cells

E. Gelmann, S. Spiegel, K. Kimura, 2003, Cell Death and Differentiation.

Sphingosine-1-Phosphate: A Lipid Second Messenger Regulating Cell Growth and Survival

S. Spiegel, O. Cuvillier, A. Olivera, 1998 .

Sphingosine 1-phosphate signal survival and mitogenesis are mediated by lipid-stereospecific binding of triacylglycerol-rich lipoproteins

S. Spiegel, A. Olivera, V. Ruíz-Gutiérrez, 2003, Cellular and Molecular Life Sciences CMLS.

Sphingosine‐1‐Phosphate in Cell Growth and Cell Death a

S. Spiegel, G. Pirianov, O. Cuvillier, 1998, Annals of the New York Academy of Sciences.

Effect of acidic phospholipids on sphingosine kinase

S. Spiegel, A. Olivera, J. Rosenthal, 1996, Journal of cellular biochemistry.

Sphingolipids Metabolites: A New Class of Second Messengers in the Regulation of Cell Growth

S. Spiegel, 1994 .

Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells

Sarah Spiegel, S. Payne, S. Milstien, 2007, FEBS letters.

1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase.

S. Spiegel, O. Cuvillier, B. Kleuser, 1998, Cancer research.

Binding of sphingosine 1-phosphate to cell surface receptors.

S. Spiegel, J. V. Van Brocklyn, 2000, Methods in enzymology.

Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors.

S. Spiegel, F. Wang, V. Nava, 1999, Cancer research.

Sphingosine-1-phosphate Inhibits Motility of Human Breast Cancer Cells Independently of Cell Surface Receptors 1

S. Spiegel, Fang Wang, V. Nava, 1999 .

Identification of Edg1 Receptor Residues That Recognize Sphingosine 1-Phosphate*

S. Spiegel, D. Baker, A. Parrill, 2000, The Journal of Biological Chemistry.

Ceramide‐induced cell death in primary neuronal cultures: Upregulation of ceramide levels during neuronal apoptosis

S. Milstien, S. Spiegel, A. Faden, 2002, Journal of neuroscience research.

Inflammatory Conditions Disrupt Constitutive Endothelial Cell Barrier Stabilization by Alleviating Autonomous Secretion of Sphingosine 1-Phosphate

S. Spiegel, R. Heller, M. Gräler, 2020, Cells.

A real-time high-throughput fluorescence assay for sphingosine kinases

S. Milstien, S. Spiegel, Santiago Lima, 2014, Journal of Lipid Research.

Biological Characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a Selective Sphingosine Kinase-2 Inhibitor and Anticancer Agent

Hardik I. Parikh, S. Spiegel, G. Kellogg, 2013, PloS one.

Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.

Eugene Y. Kim, S. Milstien, S. Spiegel, 2012, Cancer research.

Synthesis and biological evaluation of sphingosine kinase 2 inhibitors with anti‐inflammatory activity

S. Spiegel, R. Enriz, Sergio E Alvarez, 2019, Archiv der Pharmazie.

Sphingosine-1-phosphate in chronic intestinal inflammation and cancer.

S. Milstien, S. Spiegel, K. Takabe, 2014, Advances in biological regulation.

Cell membranes, methods and reviews. Volume 3. Plenum Press, New York, 1987. 417 pp. $75.00

S. Spiegel, 1989 .

The potential of histone deacetylase inhibitors in Niemann – Pick type C disease

S. Milstien, S. Spiegel, Michael Maceyka, 2013, The FEBS journal.

Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents.

L. Watkins, S. Cuzzocrea, S. Spiegel, 2020, Pain.

Sphingosine Kinase Type 2 Activation by ERK-mediated Phosphorylation*

S. Milstien, S. Spiegel, T. Kordula, 2007, Journal of Biological Chemistry.

10 Sphingosine-1-phosphate metabolism in mammalian cell signalling

S. Milstien, S. Spiegel, S. Coursol, 2004 .

Platelet‐derived growth factor‐induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCγ

S. Spiegel, A. Kazlauskas, A. Olivera, 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner.

S. Milstien, S. Spiegel, Hong Liu, 2003, Biochemistry.

Targeting the S1P Axis and Development of a Novel Therapy for Obesity Related Triple Negative Breast Cancer

S. Spiegel, 2015 .

Sphingosine Kinase Type 2 Is a Putative BH3-only Protein That Induces Apoptosis*

S. Payne, S. Milstien, S. Spiegel, 2003, Journal of Biological Chemistry.

VEGF Potentiates GD3-Mediated Immunosuppression by Human Ovarian Cancer Cells

S. Spiegel, S. Temkin, S. Goldblum, 2016, Clinical Cancer Research.

S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells

M. Care, S. Spiegel, P. Murray, 2017, Leukemia.

Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain

S. Spiegel, T. Vanderah, G. Kolar, 2019, Proceedings of the National Academy of Sciences.

Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension

S. Payne, S. Milstien, S. Spiegel, 2004, The Journal of cell biology.

K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5

Cheng Luo, Sarah Spiegel, Xiangqian Kong, 2014, Nature Immunology.

Ca2+/calmodulin-dependent translocation of sphingosine kinase: role in plasma membrane relocation but not activation.

M. J. Parkinson, S. Spiegel, K. W. Young, 2003, Cell calcium.

Activation of sphingosine kinase in pheochromocytoma PC12 neuronal cells in response to trophic factors

S. Spiegel, L. Edsall, R. Rius, 1997, FEBS letters.

ORMDL in metabolic health and disease.

S. Spiegel, Ryan D R Brown, R. Brown, 2023, Pharmacology & therapeutics.

Role of sphingolipid metabolites in the actions of growth factors and cytokines

S. Milstien, S. Spiegel, 1996 .

Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling

S. Spiegel, E. Sanchez, A. M. Leopoldino, 2015, Molecular and Cellular Biology.

Sphingosine-1-phosphate and its receptors in vascular endothelial and lymphatic barrier function

S. Spiegel, Cynthia Weigel, Jacqueline Bellaci, 2023, The Journal of biological chemistry.

Measurement of mammalian sphingosine-1-phosphate phosphohydrolase activity in vitro and in vivo.

S. Milstien, S. Spiegel, Michael Maceyka, 2007, Methods in enzymology.

S1P lyase inhibition protects against sepsis by promoting disease tolerance via the S1P/S1PR3 axis

S. Spiegel, A. Nierhaus, S. Kluge, 2020, EBioMedicine.

Membrane sialoglycolipids emerging as possible signal transducers for lymphocyte stimulation.

M. Wilchek, S. Spiegel, 1981, Journal of immunology.

The role of calcium influx in cellular proliferation induced by interaction of endogenous ganglioside GM1 with the B subunit of cholera toxin.

S. Milstien, S. Spiegel, N. E. Buckley, 1995, Biochimica et biophysica acta.

[25] Fluorescent gangliosides

S. Spiegel, 1987 .

Fluorescent derivatives of ganglioside GM1 function as receptors for cholera toxin.

S. Spiegel, 1985, Biochemistry.

Gangliosides modulate sodium transport in cultured toad kidney epithelia.

S. Spiegel, P. Fishman, J. Handler, 1986, The Journal of biological chemistry.

PDE5 Inhibitors Enhance Celecoxib Killing in Multiple Tumor Types

S. Spiegel, P. Dent, N. Cruickshanks, 2015, Journal of cellular physiology.

Shooting the messenger: oxidative stress regulates sphingosine-1-phosphate.

S. Milstien, S. Spiegel, Michael Maceyka, 2007, Circulation research.

The distribution of BrK alpha/RbK alpha peak intensity ratio in human whole blood samples. Comparison between normal and colorectal cancer cases.

S. Spiegel, S. Chaitchik, M. Kitzis, 1994, Biological trace element research.

Abstract P1-01-06: Targeting the SphK1/S1P/S1PR1 axis that connects obesity, chronic inflammation, and breast cancer metastasis

S. Milstien, S. Spiegel, T. Wakai, 2018 .

Activation of Sphingosine Kinase 1

S. Milstien, S. Spiegel, Sergio E. Alvarez, 2006 .

Examination of the role of sphingosine kinase 2 in a murine model of systemic lupus erythematosus

S. Spiegel, Quanzhen Li, K. Harikumar, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Inhibition of protein kinase C-dependent cellular proliferation by interaction of endogenous ganglioside GM1 with the B subunit of cholera toxin.

S. Spiegel, 1989, The Journal of biological chemistry.

Grafting of triggering site onto lymphocytes; distribution of grafted dinitrophenyl groups on cell surface glycoproteins and glycolipids

M. Wilchek, S. Spiegel, 2004, Molecular and Cellular Biochemistry.

Aminoacylase 1 is a sphingosine kinase 1‐interacting protein

S. Milstien, S. Spiegel, V. Nava, 2004, FEBS letters.

Oxidative Stress Regulates Sphingosine-1-Phosphate

S. Milstien, S. Spiegel, Michael Maceyka, 2006 .

Stimulation of nuclear sphingosine kinase activity by platelet‐derived growth factor

S. Milstien, S. Spiegel, B. Kleuser, 2001, FEBS letters.

Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts.

S. Spiegel, D. Rosenthal, M. Smulson, 1994, The Journal of biological chemistry.

Abstract 1694: Conjugated bile acids aggravate metastatic pancreatic cancer via sphingosine-1-phosphate receptor 2

S. Spiegel, K. Takabe, Huiping Zhou, 2016 .

Sphingosine kinase 1 activation by estrogen receptor α36 contributes to tamoxifen resistance in breast cancer

S. Milstien, S. Spiegel, J. Harrell, 2018, Journal of Lipid Research.

K63-linked polyubiquitylation of IRF1 transcription factor is essential for IL-1-induced CCL5 and CXCL10 chemokine production

M. Diamond, S. Milstien, S. Spiegel, 2014, Nature immunology.

Sphingosine and sphingosine 1-phosphate in cellular proliferation: relationship with protein kinase C and phosphatidic acid.

S. Spiegel, 1993, Journal of lipid mediators.

Synthesis and evaluation of a photolyzable derivative of sphingosine 1-phosphate--caged SPP.

S. Spiegel, A. Olivera, L. Qiao, 1998, Bioorganic & medicinal chemistry letters.

Sphingosine‐1‐phosphate inhibits IL‐1‐induced expression of C‐C motif ligand 5 via c‐Fos‐dependent suppression of IFN‐β amplification loop

S. Milstien, S. Spiegel, Lauren Bryan, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Sphingosine Kinase 2

S. Spiegel, S. Paugh, D. Kapitonov, 2007, Definitions.

Differential effects of free and liposome‐associated 1‐O‐octadecyl‐2‐O‐methylglycerophosphocholine on protein kinase C

S. Spiegel, O. Cuvillier, A. Janoff, 1999, FEBS letters.

Progress towards Understanding the Role of Gangliosides in Cell Growth Regulation

S. Spiegel, N. E. Buckley, 1990 .

Sphingosine kinase 2 in stromal fibroblasts creates a hospitable tumor microenvironment in breast cancer.

S. Milstien, S. Spiegel, M. Dozmorov, 2022, Cancer research.

Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors

J. P. Hobson, S. Spiegel, H. Kleinman, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Structural Features of EDG1 Receptor‐Ligand Complexes Revealed by Computational Modeling and Mutagenesis

S. Spiegel, D. Baker, A. Parrill, 2000, Annals of the New York Academy of Sciences.

Effects of N,N‐Dimethylsphingosine on Sphingosine Kinase

S. Milstien, S. Spiegel, S. Paugh, 2006 .