A. Gitler

发表

Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity

D. Karger, E. Fraenkel, O. King, 2009, Nature Genetics.

α-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models

S. Lindquist, A. Gitler, A. Cashikar, 2006, Science.

Stress granules as crucibles of ALS pathogenesis

Oliver D. King, Aaron D. Gitler, O. King, 2013, The Journal of cell biology.

Spontaneous driving forces give rise to protein−RNA condensates with coexisting phases and complex material properties

R. Pappu, C. Larabell, Rhiju Das, 2018, Proceedings of the National Academy of Sciences.

A suite of Gateway® cloning vectors for high‐throughput genetic analysis in Saccharomyces cerevisiae

S. Lindquist, A. Gitler, S. Alberti, 2007, Yeast.

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

Brittany N. Lasseigne, W. Chung, D. Goldstein, 2015, Science.

CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9orf72 dipeptide repeat protein toxicity

Nicholas J Kramer, Aaron D Gitler, Marc Tessier-Lavigne, 2018, Nature Genetics.

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis.

S. Lindquist, L. J. Su, A. Gitler, 2008, Proceedings of the National Academy of Sciences of the United States of America.

A matter of balance

A. Gitler, J. Fryer, 2018, eLife.

Single-cell transcriptomic analysis of the adult mouse spinal cord

Sandy L. Klemm, A. Gitler, W. Greenleaf, 2020, bioRxiv.

Cloning and characterization of zebrafish tbx1.

A. Gitler, A. Chin, L. Kochilas, 2003, Gene expression patterns : GEP.

Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations.

A. Gitler, H. Lashuel, D. Eliezer, 2016, ACS chemical biology.

Confirming Pathogenicity of the F386L PSEN1 Variant in a South Asian Family With Early-Onset Alzheimer Disease

Michaël E. Belloy, M. Greicius, G. Zaharchuk, 2021, Neurology: Genetics.

BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.

Gary D Bader, Shayne D. Wierbowski, Graham L. Cromar, 2020, Cell systems.

A cellular system that degrades misfolded proteins and protects against neurodegeneration.

Xiaolu Yang, Aaron D Gitler, Michael D Brewer, 2014, Molecular cell.

Bridging the gap between high-throughput genetic and transcriptional data reveals cellular pathways responding to alpha-synuclein toxicity

D. Karger, E. Fraenkel, O. King, 2009 .

Singling out motor neurons in the age of single-cell transcriptomics.

A. Gitler, Jacob A. Blum, 2022, Trends in genetics : TIG.

Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice

Anirvan Ghosh, A. Gitler, Z. Qiu, 2019, Translational Neurodegeneration.

Author response: A versatile system to record cell-cell interactions

Christopher W. Murray, Rui Tang, Ian L Linde, 2020 .

Hydration-dependent phase separation of a prion-like protein regulates seed germination during water stress

S. Rhee, A. Gitler, Emiel Michiels, 2020, bioRxiv.

Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice

Anirvan Ghosh, A. Gitler, Z. Qiu, 2019, Translational neurodegeneration.

Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice

Anirvan Ghosh, A. Gitler, Z. Qiu, 2018, bioRxiv.

Molecular markers of cardiac endocardial cushion development

J. Epstein, M. Lu, A. Gitler, 2003, Developmental dynamics : an official publication of the American Association of Anatomists.

Another Reason to Exercise

A. Gitler, 2011, Science.

Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein

E. Masliah, J. Frydman, K. Shen, 2015, Neuron.

It's all starting to come together

A. Gitler, Lindsay A. Becker, 2015, eLife.

Why you always in a mood? Pumpin’ polyP, actin’ brand new

A. Gitler, Kevin A. Guttenplan, 2022, Neuron.

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

Mark T. W. Ebbert, L. Petrucelli, D. Dickson, 2018, Nature Medicine.

Modeling Human Disease

R. Lehmann, A. Gitler, 2012, Science.

Compartmentalization of superoxide dismutase 1 (SOD1G93A) aggregates determines their toxicity

A. Gitler, Y. Soen, R. Lyakhovetsky, 2012, Proceedings of the National Academy of Sciences.

Nf1 has an essential role in endothelial cells

J. Epstein, A. Gitler, L. Parada, 2003, Nature Genetics.

Tie2-Cre–Induced Inactivation of a Conditional Mutant Nf1 Allele in Mouse Results in a Myeloproliferative Disorder that Models Juvenile Myelomonocytic Leukemia

J. Epstein, W. Pear, A. Gitler, 2004, Pediatric Research.

Clogging information flow in ALS

A. Gitler, Joseph W Paul, 2014, Science.

Prion-like domain mutations in hnRNPs cause multisystem proteinopathy and ALS

Emily A. Scarborough, J. Trojanowski, A. Pestronk, 2013 .

Glycolytic Enzymes Coale sce in G Bodies under Hypoxic Stress Graphical Abstract Highlights

J. Yates, John K. Kim, D. Klionsky, 2022 .

Radiogenomics of C9orf72 Expansion Carriers Reveals Global Transposable Element Derepression and Enables Prediction of Thalamic Atrophy and Clinical Impairment

Josiah K. Leong, L. Sugrue, K. Rankin, 2022, The Journal of Neuroscience.

You come at the misfolded proteins, you best not miss.

A. Gitler, Steven Boeynaems, 2021, Trends in biochemical sciences.

Macromolecular Connectivity Landscape of Mammalian Brain

Gary D Bader, Shayne D. Wierbowski, A. Emili, 2018 .

Variants in KIAA0825 underlie autosomal recessive postaxial polydactyly

D. Nickerson, S. Leal, D. Horn, 2019, Human Genetics.

ALS-Associated Ataxin 2 PolyQ Expansions Enhance Stress-Induced Caspase 3 Activation and Increase TDP-43 Pathological Modifications

A. Gitler, M. Hart, 2012, The Journal of Neuroscience.

Ataxin-2 intermediate-length polyglutamine expansions in European ALS patients.

P. Andersen, A. Gitler, M. de Carvalho, 2011, Human molecular genetics.

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport

J. Rothstein, A. Gitler, J. Taylor, 2018, Cell.

Targeted next-generation sequencing improves diagnosis of hereditary spastic paraplegia in Chinese patients

A. Gitler, W. Ni, Qiao Wei, 2018, Journal of Molecular Medicine.

The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems

L. Shapiro, E. Villa, A. Gitler, 2022, Nature Communications.

Neural crest migration and mouse models of congenital heart disease.

J. Epstein, A. Gitler, L. Kochilas, 2002, Cold Spring Harbor symposia on quantitative biology.

Identification and functional analysis of novel mutations in the SOD1 gene in Chinese patients with amyotrophic lateral sclerosis

A. Gitler, Qiao Wei, Hong-Fu Li, 2019, Amyotrophic lateral sclerosis & frontotemporal degeneration.

A neurodegenerative-disease protein forms beneficial aggregates in healthy muscle

A. Gitler, Lindsay A. Becker, 2018, Nature.

Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis.

H. Hakonarson, Cecilia Kim, J. Trojanowski, 2012, Human molecular genetics.

Cracking the cryptic code in amyotrophic lateral sclerosis and frontotemporal dementia: Towards therapeutic targets and biomarkers

L. Petrucelli, A. Gitler, Yuka Koike, 2022, Clinical and translational medicine.

PolyQ Repeat Expansions in ATXN2 Associated with ALS Are CAA Interrupted Repeats

John Q. Trojanowski, Zhenming Yu, Aaron D. Gitler, 2011, PloS one.

Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models

Matthew J. Higgins, Nevan J. Krogan, Steven Finkbeiner, 2012, Nature Genetics.

Neurodegenerative gene’s function is not all about those bases

A. Gitler, Olivia Gautier, 2020, Nature.

The modulation of Amyotrophic Lateral Sclerosis risk by Ataxin-2 intermediate polyglutamine expansions is a specific effect

R. Krüger, A. Kurz, P. Andersen, 2012, Neurobiology of Disease.

Efficient Prevention of Neurodegenerative Diseases by Depletion of Starvation Response Factor Ataxin-2

A. Gitler, D. Meierhofer, G. Auburger, 2017, Trends in Neurosciences.

Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity

D. Mann, C. Troakes, A. Gitler, 2019, Acta Neuropathologica.

The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease

Oliver D. King, Aaron D. Gitler, O. King, 2012, Brain Research.

Evaluating noncoding nucleotide repeat expansions in amyotrophic lateral sclerosis

Anna T. Thomas, A. Gitler, Matthew D. Figley, 2014, Neurobiology of Aging.

Evaluating non-coding nucleotide repeat expansions in amyotrophic lateral sclerosis

A. Gitler, Matthew D. Figley, Anna Thomas, 2014 .

Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development

Michael P. O’Donnell, A. Gitler, P. S. Klein, 2006, Development.

Regulating Heart Development: The Role of Nf1

J. Epstein, A. Gitler, 2003, Cell cycle.

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene in and for Therapeutic

Timothy A. Miller, Denis C. Bauer, Shankaracharya, 2018 .

RPS 25 is required for efficient RAN translation of C 9 orf 72 and other 3 neurodegenerative disease-associated nucleotide repeats 4 5

L. Petrucelli, L. Partridge, J. Puglisi, 2019 .

Mesoscale connections and gene expression empower whole-brain modeling of α-synuclein spread, aggregation, and decay dynamics.

Gregor Bieri, A. Gitler, R. Melki, 2022, Cell reports.

Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2

Caitlin M. Rodriguez, A. Gitler, M. Bassik, 2022, Cell reports.

Rnq1! You are still dangerous, but you can be my wingman anytime.

A. Gitler, Caiwei Guo, 2022, Molecular cell.

Targeted next-generation sequencing improves diagnosis of hereditary spastic paraplegia in Chinese patients

A. Gitler, W. Ni, Qiao Wei, 2018, Journal of Molecular Medicine.

These violent repeats have violent extends

A. Gitler, Julien Couthouis, 2018, Neurology: Genetics.

Hunting the G-unit in Huntington's.

A. Gitler, Brenda Huang, 2018, Brain : a journal of neurology.

Defects in trafficking bridge Parkinson's disease pathology and genetics

A. Gitler, A. Abeliovich, 2016, Nature.

A memory of eS25 loss drives resistance phenotypes

Christopher P. Lapointe, Ryan A. Flynn, J. Puglisi, 2020, Nucleic acids research.

“A memory of RPS25 loss drives resistance phenotypes”

Christopher P. Lapointe, Ryan A. Flynn, J. Puglisi, 2019, bioRxiv.

Glycolytic Enzymes Coalesce in G Bodies under Hypoxic Stress.

J. Yates, John K. Kim, D. Klionsky, 2017, Cell reports.

Kinetic Analysis of npBAF to nBAF Switching Reveals Exchange of SS18 with CREST and Integration with Neural Developmental Pathways

G. Crabtree, A. Gitler, B. Staahl, 2013, The Journal of Neuroscience.

Neurodegenerative disease: models, mechanisms, and a new hope

Paraminder Dhillon, Aaron D. Gitler, A. Gitler, 2017, Disease Models & Mechanisms.

Variants in KIAA0825 underlie autosomal recessive postaxial polydactyly

D. Nickerson, S. Leal, D. Horn, 2019, Human Genetics.

Hop Is an Unusual Homeobox Gene that Modulates Cardiac Development

R. Schwartz, J. Epstein, J. Novotný, 2002, Cell.

Distinct repertoires of microRNAs present in mouse astrocytes compared to astrocyte-secreted exosomes

A. Gitler, A. Jovičić, 2017, PloS one.

Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivatives.

J. Epstein, A. Gitler, Maozhen Zhang, 2005, Developmental biology.

Targeted Exon Capture and Sequencing in Sporadic Amyotrophic Lateral Sclerosis

R. Daneshjou, A. Gitler, Julien Couthouis, 2014, PLoS genetics.

Exome sequencing to identify de novo mutations in sporadic ALS trios

G. Crabtree, O. King, J. Glass, 2013, Nature Neuroscience.

Neurotoxic reactive astrocytes induce cell death via saturated lipids

B. Barres, A. Gitler, G. Chopra, 2021, Nature.

Internalization, axonal transport and release of fibrillar forms of alpha-synuclein

Gregor Bieri, A. Gitler, M. Brahic, 2018, Neurobiology of Disease.

ATXN2 trinucleotide repeat length correlates with risk of ALS

Ashley R. Jones, J. Hardy, Yi-Chung Lee, 2017, Neurobiology of Aging.

Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons

Sandy L. Klemm, A. Gitler, W. Greenleaf, 2020, Nature Neuroscience.

Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model

B. Barres, A. Gitler, S. Liddelow, 2020, Nature Communications.

Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD

K. Verstrepen, C. van Broeckhoven, W. Robberecht, 2016, Scientific Reports.

GTPase Activity Plays a Key Role in the Pathobiology of LRRK2

A. Gitler, X. Li, T. Dawson, 2010, PLoS genetics.

Prion-like disorders: blurring the divide between transmissibility and infectivity

O. King, A. Gitler, J. Shorter, 2010, Journal of Cell Science.

TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity*

A. Gitler, J. Shorter, J. McCaffery, 2009, The Journal of Biological Chemistry.

Evolution of a Human-Specific Tandem Repeat Associated with ALS.

E. Eichler, M. Kay, A. Gitler, 2020, American journal of human genetics.

Semaphorin-plexin signaling guides patterning of the developing vasculature.

S. D. Fraser, M. Fishman, J. Epstein, 2004, Developmental cell.

PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development.

J. Epstein, M. Lu, A. Gitler, 2004, Developmental cell.

Old moms say, no Sir

A. Gitler, Daniel F. Jarosz, 2017, Science.

α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

S. Lindquist, A. Gitler, A. Cooper, 2009, Nature Genetics.

Prion-like domain mutations in hnRNPs cause multisystem proteinopathy and ALS

Michael Benatar, Steven A Greenberg, Aaron D Gitler, 2013, Nature.

ALS Genetics: Gains, Losses, and Implications for Future Therapies

A. Gitler, Garam Kim, Olivia Gautier, 2020, Neuron.

Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains

Julie C. Sung, O. King, A. Gitler, 2018, Cell.

Nuclear transport dysfunction: a common theme in amyotrophic lateral sclerosis and frontotemporal dementia

A. Gitler, A. Jovičić, Joseph W Paul, 2016, Journal of neurochemistry.

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia

Robert H. Brown, R. Petersen, B. Boeve, 2016, Nature Communications.

Distinct TDP-43 pathology in ALS patients with ataxin 2 intermediate-length polyQ expansions

J. Trojanowski, V. Lee, A. Gitler, 2012, Acta Neuropathologica.

Local RNA Translation at the Synapse and in Disease

S. Warren, E. Klann, A. Gitler, 2011, The Journal of Neuroscience.

A yeast functional screen predicts new candidate ALS disease genes

J. Trojanowski, R. Kalb, D. Dickson, 2011, Proceedings of the National Academy of Sciences.

RNA-binding proteins with prion-like domains in ALS and FTLD-U

A. Gitler, J. Shorter, 2011, Prion.

Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS

A. Gitler, A. Chesi, J. Shorter, 2011, PLoS biology.

NOVEL GENE TARGETS ASSOCIATED WITH AMYOTROPHIC LATERAL SCLEROSIS AND METHODS OF USE THEREOF

A. Gitler, 2011 .

Opposing roles of p38α-mediated phosphorylation and arginine methylation in driving TDP-43 proteinopathy

S. Finkbeiner, N. Brandon, A. Gitler, 2021, bioRxiv.

TDP-43 in ALS: Stay on Target…Almost There

A. Gitler, A. Jovičić, 2014, Neuron.

TDP-43 and FUS/TLS yield a target-rich haul in ALS

A. Gitler, 2012, Nature Neuroscience.

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity

S. Lindquist, A. Gitler, J. McCaffery, 2008, Proceedings of the National Academy of Sciences.

TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A

Caitlin M. Rodriguez, Beryl B. Cummings, Laura R. Ganser, 2021, Nature.

Susan Lee Lindquist (1949–2016)

A. Gitler, J. Shorter, 2016, Nature.

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

John Q. Trojanowski, Georg Auburger, Arun Padmanabhan, 2010, Nature.

p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)

Patricia A. Castruita, D. Geschwind, L. Petrucelli, 2021, Cell.

Cloning and expression analysis of murine lupin, a member of a novel gene family that is conserved through evolution and associated with Lupus inclusions

J. Epstein, A. Gitler, X. Ma, 2000, Development Genes and Evolution.

A versatile system to record cell-cell interactions

Rui Tang, Christopher W Murray, Ian L Linde, 2020, eLife.

G-baToN: a versatile reporter system for cancer cell-stromal cell interactions

Min K. Tsai, A. Gitler, E. Engleman, 2020, bioRxiv.

G-baToN: a versatile cell-cell interaction reporter system

Min K. Tsai, A. Gitler, E. Engleman, 2020 .

C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility

P. van Damme, A. Gitler, S. Chandran, 2019, Science Advances.

Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop.

J. Epstein, V. Ferrari, M. Lu, 2003, The Journal of clinical investigation.

Apakaochtodenes A and B: two tetrahalogenated monoterpenes from the red marine alga Portieria hornemannii.

A. Gitler, D. Kingston, V. Paul, 1999, Journal of natural products.

Synthesis and biological activity of semipeptoid farnesyltransferase inhibitors.

A. Gitler, A. Levitzki, C. Gilon, 1997, Bioorganic & medicinal chemistry.

Poly(A)-binding protein is an ataxin-2 chaperone that emulsifies biomolecular condensates

A. Gitler, I. Ruiz-Trillo, Steven Boeynaems, 2021, bioRxiv.

The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis

S. Lindquist, L. J. Su, A. Gitler, 2008, Proceedings of the National Academy of Sciences.

The epidemiology and genetics of Amyotrophic lateral sclerosis in China

A. Gitler, D. Fan, Xiao-lu Liu, 2018, Brain Research.

RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats

L. Petrucelli, L. Partridge, J. Puglisi, 2019, Nature Neuroscience.

A new approach for rare variation collapsing on functional protein domains implicates specific genic regions in ALS

Brittany N. Lasseigne, D. Goldstein, R. Myers, 2019, Genome research.

Regional Collapsing of Rare Variation Implicates Specific Genic Regions in ALS

Brittany N. Lasseigne, D. Goldstein, R. Myers, 2018, bioRxiv.

Exome sequencing identifies a DNAJB6 mutation in a family with dominantly-inherited limb-girdle muscular dystrophy

K. Flanigan, A. Gitler, J. Buenrostro, 2014, Neuromuscular Disorders.

Regrowing axons with alternative splicing

A. Gitler, N. Kramer, 2016, eLife.

Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts

Stanley N Cohen, L. Petrucelli, R. Petersen, 2016, Science.

Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.

L. Petrucelli, A. Gitler, M. Parisi, 2019, Nature Neuroscience.

Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS

F. Gage, J. Mertens, W. Robberecht, 2015, Nature Neuroscience.

Modifiers of C9orf72 DPR toxicity implicate nucleocytoplasmic transport impairments in c9FTD/ALS

F. Gage, J. Mertens, W. Robberecht, 2015, Nature neuroscience.

A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation

S. Rhee, G. Bassel, A. Gitler, 2021, Cell.

Yeast screen for modifiers of C9orf72 poly(glycine-arginine) dipeptide repeat toxicity

A. Gitler, Noori Chai, 2018, FEMS yeast research.

Therapeutic modulation of eIF2α-phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

J. Trojanowski, S. Finkbeiner, V. Lee, 2013, Nature Genetics.

A yeast model for polyalanine-expansion aggregation and toxicity

A. Gitler, R. Gardner, Catherine A. Konopka, 2011, Molecular biology of the cell.

Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis

A. Burlingame, J. Trojanowski, E. Huang, 2016, Neuron.

The Role of the Parkinson's Disease Gene PARK9 in Essential Cellular Pathways and the Manganese Homeostasis Network in Yeast

X. Fang, A. Gitler, A. Cooper, 2012, PloS one.

Analysis of COPII Vesicles Indicates a Role for the Emp47–Ssp120 Complex in Transport of Cell Surface Glycoproteins

A. Gitler, C. Barlowe, Joshua D. Wilson, 2016, Traffic.

High-throughput yeast plasmid overexpression screen.

A. Gitler, M. Fleming, 2011, Journal of visualized experiments : JoVE.

TDP-43 toxicity in yeast.

A. Gitler, M. Hart, Maria Armakola, 2011, Methods.

Beer and Bread to Brains and Beyond: Can Yeast Cells Teach Us about Neurodegenerative Disease?

A. Gitler, 2007, Neurosignals.

Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72

A. Gitler, D. Morgens, Michael S. Haney, 2019, Brain Research.

Disease models and mechanisms in the classroom

A. Gitler, 2009, Disease Models & Mechanisms.

Small molecule v-ATPase inhibitor Etidronate lowers levels of ALS protein ataxin-2

Caitlin M. Rodriguez, A. Gitler, M. Bassik, 2021, bioRxiv.

Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein

E. Masliah, J. Frydman, K. Shen, 2023, Neuron.

Discovery and characterization of three novel synuclein genes in zebrafish

A. Gitler, Zhihui Sun, 2008, Developmental dynamics : an official publication of the American Association of Anatomists.

Model Organisms Reveal Insight into Human Neurodegenerative Disease: Ataxin-2 Intermediate-Length Polyglutamine Expansions Are a Risk Factor for ALS

A. Gitler, N. Bonini, 2011, Journal of Molecular Neuroscience.

Targeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2

Caitlin M. Rodriguez, S. Strittmatter, A. Gitler, 2021, bioRxiv.

Exome sequencing identifies a DNAJB 6 mutation in a family with dominantly-inherited limb-girdle muscular dystrophy

K. Flanigan, A. Gitler, J. Buenrostro, 2014 .

Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1

Gregor Bieri, A. Gitler, M. Brahic, 2016, Acta Neuropathologica.

The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.

A. Gitler, J. Holton, H. Lashuel, 2014, Human molecular genetics.

Therapeutic reduction of ataxin 2 extends lifespan and reduces pathology in TDP-43 mice

David A. Knowles, S. Pulst, Gregor Bieri, 2017, Nature.

Axons Gonna Ride ’til They Can’t No More

A. Gitler, Steven Boeynaems, 2019, Neuron.

Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation.

Daniela C. Zarnescu, D. Zarnescu, A. Gitler, 2015, Human molecular genetics.

Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease

Allie C. Obermeyer, Garrett M. Ginell, A. Kundaje, 2023, bioRxiv.

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

L. Petrucelli, D. Dickson, A. Gitler, 2018, Nature Medicine.

Profilin 1 Associates with Stress Granules and ALS-Linked Mutations Alter Stress Granule Dynamics

Gregor Bieri, A. Gitler, J. Taylor, 2014, The Journal of Neuroscience.

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons

Gregor Bieri, A. Gitler, M. Shamloo, 2019, bioRxiv.

Pour Some Sugar on TDP(-43).

A. Gitler, Steven Boeynaems, 2018, Molecular cell.

TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity.

A. Gitler, J. Shorter, J. McCaffery, 2009, Journal of Biological Chemistry.

A blinded international study on the reliability of genetic testing for GGGGCC-repeat expansions in C9orf72 reveals marked differences in results among 14 laboratories

C. van Broeckhoven, C. Shaw, P. Andersen, 2014, Journal of Medical Genetics.

Evidence that alpha-synuclein does not inhibit phospholipase D.

D. Selkoe, S. Lindquist, A. Gitler, 2009, Biochemistry.

There has been an awakening: Emerging mechanisms of C9orf72 mutations in FTD/ALS

A. Gitler, H. Tsuiji, 2016, Brain Research.

Yeast genetic screen reveals novel therapeutic strategy for ALS

A. Gitler, Matthew D. Figley, 2013, Rare diseases.

Ataxin-2 Is Droppin’ Some Knowledge

A. Gitler, Lindsay A. Becker, 2018, Neuron.

Neurodegeneration: A Leg Up on TDP-43

A. Gitler, Matthew D. Figley, 2015, Current Biology.

Evaluating the prevalence of polyglutamine repeat expansions in amyotrophic lateral sclerosis

A. Gitler, N. Bonini, A. Chesi, 2011, Neurology.

A modular platform for engineering function of natural and synthetic biomolecular condensates

L. Shapiro, E. Villa, A. Gitler, 2021, bioRxiv.

Parallel PARKing: Parkinson’s Genes Function in Common Pathway

A. Gitler, R. Chuang, 2013, Neuron.

A Template for New Drugs against Alzheimer’s Disease

A. Aguzzi, A. Gitler, 2013, Cell.

ERAD defects and the HFE-H63D variant are associated with increased risk of liver damages in Alpha 1-Antitrypsin Deficiency

P. Fergelot, A. Gitler, H. Vignaud, 2017, PloS one.

Congenital muscular dystrophy and generalized epilepsy caused by GMPPB mutations

A. Gitler, C. Siskind, J. Day, 2014, Brain Research.

Phenotypic Heterogeneity among GBA p.R202X Carriers in Lewy Body Spectrum Disorders

T. Montine, M. Greicius, G. Davidzon, 2022, Biomedicines.

A 3’UTR Insertion Is a Candidate Causal Variant at the TMEM106B Locus Associated with Increased Risk for FTLD-TDP

Michaël E. Belloy, A. Wagner, M. Greicius, 2023, medRxiv.

In search of lost trafficking.

A. Gitler, S. Bechek, 2018, Brain : a journal of neurology.

Prime Time for α-Synuclein

A. Gitler, J. Shorter, 2007, The Journal of Neuroscience.

Evidence that α -Synuclein Does Not Inhibit Phospholipase D †

D. Selkoe, S. Lindquist, A. Gitler, 2009 .

A neurodegenerative-disease protein forms beneficial aggregates in healthy muscle

A. Gitler, Lindsay A. Becker, 2018, Nature.

CRISPR–Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity

Gregor Bieri, A. Gitler, M. Tessier-Lavigne, 2018, Nature Genetics.

TDP-43 IS INTRINSICALLY AGGREGATION-PRONE AND ALS- LINKED MUTATIONS ACCELERATE AGGREGATION AND INCREASE TOXICITY

A. Gitler, J. Shorter, J. McCaffery, 2009 .

Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice

Anirvan Ghosh, A. Gitler, Z. Qiu, 2018, Translational Neurodegeneration.

Poly(A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates.

A. Gitler, A. Holehouse, I. Ruiz-Trillo, 2023, Molecular cell.

Phosphorylation Leads the Way for Protein Aggregate Disassembly.

A. Gitler, Steven Boeynaems, 2018, Developmental cell.

Supplemental Information Activation of HIPK 2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis

A. Burlingame, J. Trojanowski, E. Huang, 2016 .

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Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.

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Human motor neurons are rare and can be transcriptomically divided into known subtypes

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Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein

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CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9orf72 dipeptide repeat protein toxicity

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Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis.

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Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.

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α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

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A molecular atlas of adult C. elegans motor neurons reveals ancient diversity delineated by conserved transcription factor codes

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BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.

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Discovery and characterization of three novel synuclein genes in zebrafish

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Modifiers of C9orf72 DPR toxicity implicate nucleocytoplasmic transport impairments in c9FTD/ALS

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SPECIAL COLLECTION : NEURODEGENERATION Neurodegenerative disease : models , mechanisms , and a new hope

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