V. Oikonen

U Ruotsalainen, J O Rinne, K. Någren, 1993, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Measurement of Serotonin 5-HT1A Receptor Binding Using Positron Emission Tomography and [carbonyl-11C]WAY-100635—Considerations on the Validity of Cerebellum as a Reference Region

Kjell Någren, Jussi Hirvonen, Jarmo Hietala, 2007 .

Whole-body distribution and metabolism of [N-methyl-11C](R)-1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinolinecarboxamide in humans; an imaging agent for in vivo assessment of peripheral benzodiazepine receptor activity with positron emission tomography

Tuula Tolvanen, Kjell Någren, Jussi Hirvonen, 2009, European Journal of Nuclear Medicine and Molecular Imaging.

Insulin stimulates liver glucose uptake in humans: an 18F-FDG PET Study.

Juhani Knuuti, Vesa Oikonen, Pirjo Nuutila, 2003, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Parametric Binding Images of the TSPO Ligand 18F-DPA-714

R. Boellaard, A. Lammertsma, R. Schuit, 2016, The Journal of Nuclear Medicine.

Imaging perfusion and hypoxia with PET to predict radiotherapy response in head-and-neck cancer.

Tove Grönroos, Heikki Minn, Vesa Oikonen, 2004, International Journal of Radiation Oncology, Biology, Physics.

Non-Invasive Estimation of Subcutaneous and Visceral Adipose Tissue Blood Flow by Using [15O]H2O PET with Image Derived Input Functions

P. Iozzo, H. Sipilä, V. Oikonen, 2007 .

Regulation of human skeletal muscle perfusion and its heterogeneity during exercise in moderate hypoxia.

V. Oikonen, J. Knuuti, R. Boushel, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

Regional Effects of Donepezil and Rivastigmine on Cortical Acetylcholinesterase Activity in Alzheimer’s Disease

K. Någren, V. Oikonen, J. Rinne, 2002, Journal of clinical psychopharmacology.

Xenon Does Not Affect γ-Aminobutyric Acid Type A Receptor Binding in Humans

Kjell Någren, Vesa Oikonen, Elina Salmi, 2008, Anesthesia and analgesia.

Sevoflurane and Propofol Increase 11C-Flumazenil Binding to Gamma-Aminobutyric AcidA Receptors in Humans

S. Aalto, K. Någren, J. Hietala, 2004, Anesthesia and analgesia.

Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rats

P. Low, S. Helin, V. Oikonen, 2019, Journal of Neuroinflammation.

Quanti fi cation of [ 18 F ] DPA-714 binding in the human brain : initial studies in healthy controls and Alzheimer ’ s disease patients

R. Boellaard, A. Lammertsma, R. Schuit, 2015 .

ORIGINAL ARTICLE Quantification of ( 18 F)DPA-714 binding in the human brain: initial studies in healthy controls and Alzheimer's disease patients

R. Boellaard, A. Lammertsma, R. Schuit, 2015 .

PET studies on brain monoamine transporters with carbon-11-beta-CIT in Parkinson's disease.

K. Någren, V. Oikonen, J. Rinne, 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Quantitative blood flow measurement of skeletal muscle using oxygen-15-water and PET.

U Ruotsalainen, P M Bloomfield, M Teräs, 1997, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

QUANTIFICATION OF OXYGEN CONSUMPTION IN SKELETAL MUSCLE WITH PET AND OXYGEN-15 BOLUS

V. Oikonen, U. Ruotsalainen, P. Nuutila, 1997 .

Extrastriatal dopamine D2 and D3 receptors in early and advanced Parkinson’s disease

V Kaasinen, J O Rinne, K. Någren, 2000, Neurology.

Human obesity is characterized by defective fat storage and enhanced muscle fatty acid oxidation, and trimetazidine gradually counteracts these abnormalities.

P. Iozzo, K. Någren, V. Oikonen, 2011, American journal of physiology. Endocrinology and metabolism.

Dimeric [68Ga]DOTA-RGD Peptide Targeting αvβ3 Integrin Reveals Extracellular Matrix Alterations after Myocardial Infarction

S. Helin, V. Oikonen, J. Knuuti, 2014, Molecular Imaging and Biology.

18F-FDG assessment of glucose disposal and production rates during fasting and insulin stimulation: a validation study.

P. Iozzo, V. Oikonen, J. Knuuti, 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Pancreatic metabolism, blood flow, and β-cell function in obese humans.

P. Iozzo, V. Oikonen, R. Parkkola, 2014, The Journal of clinical endocrinology and metabolism.

Free fatty acid uptake in the myocardium and skeletal muscle using fluorine-18-fluoro-6-thia-heptadecanoic acid.

V. Oikonen, J. Knuuti, P. Nuutila, 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Validation of [18F]fluorodeoxyglucose and positron emission tomography (PET) for the measurement of intestinal metabolism in pigs, and evidence of intestinal insulin resistance in patients with morbid obesity

P. Iozzo, V. Oikonen, J. Knuuti, 2013, Diabetologia.

Quantitative blood flow measurement of skeletal muscle using oxygen-15-water and PET.

H. Iida, H. Sipilä, V. Oikonen, 1997, Journal of Nuclear Medicine.

The renal blood flow reserve in healthy humans and patients with atherosclerotic renovascular disease measured by positron emission tomography using [15O]H2O

H. Iida, V. Oikonen, P. Nuutila, 2018, EJNMMI Research.

The effect of revascularization of renal artery stenosis on renal perfusion in patients with atherosclerotic renovascular disease.

V. Oikonen, T. Vahlberg, P. Nuutila, 2012, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Renal vascular resistance is increased in patients with kidney transplant

H. Iida, V. Oikonen, P. Nuutila, 2019, BMC Nephrology.

Comparison of: (2S,4R)-4-[18F]Fluoroglutamine, [11C]Methionine, and 2-Deoxy-2-[18F]Fluoro-D-Glucose and Two Small-Animal PET/CT Systems Imaging Rat Gliomas

S. Helin, V. Oikonen, H. Minn, 2021, Frontiers in Oncology.

ventilationmaps of regional blood flow and regional

R. Glenny, V. Oikonen, J. Knuuti, 2013 .

The effects of bariatric surgery on pancreatic lipid metabolism and blood flow.

P. Iozzo, V. Oikonen, J. Hannukainen, 2015, The Journal of clinical endocrinology and metabolism.

Uptake of 18F-rhPSMA-7.3 in Positron Emission Tomography Imaging of Prostate Cancer: A Phase 1 Proof-of-Concept Study.

V. Oikonen, M. Scheinin, P. Taimen, 2021, Cancer biotherapy & radiopharmaceuticals.

Liver uptake of free fatty acids in vivo in humans as determined with 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid and PET

P. Iozzo, V. Oikonen, J. Knuuti, 2003, European Journal of Nuclear Medicine and Molecular Imaging.

Effects of meal and incretins in the regulation of splanchnic blood flow

L. Groop, V. Oikonen, R. Parkkola, 2017, Endocrine connections.

Glucagon-like peptide-1 receptor expression after myocardial infarction: Imaging study using 68Ga-NODAGA-exendin-4 positron emission tomography

V. Oikonen, J. Knuuti, P. Nuutila, 2018, Journal of Nuclear Cardiology.

Measurement of serotonin 5-HT1A receptor binding using positron emission tomography and [carbonyl-11C]WAY-100635—considerations on the validity of cerebellum as a reference region

J. Hirvonen, K. Någren, J. Hietala, 2006, NeuroImage.

Dissociation of peak vascular conductance andV?o

Y. Hellsten, K. Beck, V. Oikonen, 2015 .

14(R,S)-[18F]Fluoro-6-thia-heptadecanoic acid as a tracer of free fatty acid uptake and oxidation in myocardium and skeletal muscle

V. Oikonen, J. Knuuti, P. Nuutila, 2002, European Journal of Nuclear Medicine and Molecular Imaging.

In all published studies, the standard one-tissue compartment model with parameters RBF (renal blood flow), p (partition coefficient, and RBV (renal blood volume) was used. Table 1. Published studies applying ( 15 O)H2O PET for estimating cortical renal blood flow.

V. Oikonen, 2005 .

Analysis of renal perfusion from [ 15 O ] H 2 O PET studies : Pixel-by-pixel calculation with and without RBV estimation Aim

V. Oikonen, 2005 .

Online Appendix – Supplemental Material

P. Iozzo, J. Hirvonen, K. Någren, 2022 .

Folate Receptor β–Targeted PET Imaging of Macrophages in Autoimmune Myocarditis

P. Low, V. Oikonen, J. Knuuti, 2020, The Journal of Nuclear Medicine.

Different metabolic responses of human brown adipose tissue to activation by cold and insulin.

J. Orava, V. Oikonen, M. Scheinin, 2011, Cell metabolism.

Defective liver disposal of free fatty acids in patients with impaired glucose tolerance.

P. Iozzo, V. Oikonen, J. Knuuti, 2004, The Journal of clinical endocrinology and metabolism.

First-in-Humans Study of 68Ga-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1

V. Oikonen, J. Knuuti, S. Jalkanen, 2020, The Journal of Nuclear Medicine.

Measurement of striatal and thalamic dopamine D2 receptor binding with 11C-raclopride

J. Hirvonen, S. Aalto, K. Någren, 2003, Nuclear medicine communications.

Quantification of the purinergic P2X7 receptor with [11C]SMW139 improves through correction for brain-penetrating radiometabolites

P. Fazio, C. Halldin, A. Windhorst, 2022, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Xenon Does Not Affect (cid:1) -Aminobutyric Acid Type A Receptor Binding in Humans

S. Aalto, K. Någren, L. Metsähonkala, 2018 .

Absorption, distribution and excretion of intravenously injected 68Ge/68Ga generator eluate in healthy rats, and estimation of human radiation dosimetry

V. Oikonen, M. Teräs, H. Liljenbäck, 2015, EJNMMI Research.

Assessment of blood flow with (68)Ga-DOTA PET in experimental inflammation: a validation study using (15)O-water.

H. Sipilä, V. Oikonen, J. Johansson, 2014, American journal of nuclear medicine and molecular imaging.

Insulin-mediated hepatic glucose uptake is impaired in type 2 diabetes: evidence for a relationship with glycemic control.

P. Iozzo, V. Oikonen, J. Knuuti, 2003, The Journal of clinical endocrinology and metabolism.

Photoperiod modulates mu-opioid receptor availability in brown adipose tissue

L. Nummenmaa, S. Helin, V. Oikonen, 2022, bioRxiv.

Measurement of GABAA receptor binding in vivo with [11C]Flumazenil: A test–retest study in healthy subjects

Kjell Någren, Jussi Hirvonen, Jussi Virkkala, 2008, NeuroImage.

Non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver

P. Iozzo, V. Oikonen, J. Knuuti, 2004, Diabetologia.

Skeletal muscle blood flow and oxygen uptake at rest and during exercise in humans: a pet study with nitric oxide and cyclooxygenase inhibition.

Y. Hellsten, B. Saltin, H. Sipilä, 2011, American journal of physiology. Heart and circulatory physiology.

Visualization and Quantification of Neurokinin-1 (NK1) Receptors in the Human Brain

Päivi Marjamäki, Tove Grönroos, Merja Haaparanta, 2005, Molecular Imaging and Biology.

[18F]fluorodopa PET shows striatal dopaminergic dysfunction in juvenile neuronal ceroid lipofuscinosis.

V. Oikonen, J. Rinne, I. Järvelä, 1997, Journal of neurology, neurosurgery, and psychiatry.

Insulin Resistance Is Associated With Enhanced Brain Glucose Uptake During Euglycemic Hyperinsulinemia: A Large-Scale PET Cohort

M. Laakso, P. Iozzo, L. Nummenmaa, 2021, Diabetes Care.

Striatal uptake of a novel PET ligand, [18F]β‐CFT, is reduced in early Parkinson's disease

V. Oikonen, J. Rinne, H. Ruottinen, 1999, Synapse.

68Ga-Citrate PET of Healthy Men: Whole-Body Biodistribution Kinetics and Radiation Dose Estimates

V. Oikonen, A. Saraste, L. Pirilä, 2022, The Journal of Nuclear Medicine.

perfusion heterogeneity exercise on human skeletal muscle perfusion and Comparison of exogenous adenosine and voluntary

V. Oikonen, J. Knuuti, J. Hannukainen, 2015 .

Comparison of exogenous adenosine and voluntary exercise on human skeletal muscle perfusion and perfusion heterogeneity.

Y. Hellsten, V. Oikonen, J. Knuuti, 2010, Journal of applied physiology.

Kinetic analysis and optimisation of 18F-rhPSMA-7.3 PET imaging of prostate cancer

V. Oikonen, M. Scheinin, P. Boström, 2021, European Journal of Nuclear Medicine and Molecular Imaging.

The Effects of Xenon Anesthesia on the Relationship Between Cerebral Glucose Metabolism and Blood Flow in Healthy Subjects: A Positron Emission Tomography Study

S. Aalto, V. Oikonen, R. Parkkola, 2009, Anesthesia and analgesia.

Uptake of 4-borono-2-[18F]fluoro-L-phenylalanine in sporadic and neurofibromatosis 2-related schwannoma and meningioma studied with PET

V. Oikonen, J. Jääskeläinen, H. Minn, 2006, European Journal of Nuclear Medicine and Molecular Imaging.

Renal hemodynamics and fatty acid uptake: effects of obesity and weight loss.

P. Iozzo, H. Iida, V. Oikonen, 2019, American journal of physiology. Endocrinology and metabolism.

3-isoquinolinecarboxamide in humans; an imaging agent for in vivo assessment of peripheral benzodiazepine receptor activity with positron emission tomography

J. Hirvonen, K. Någren, V. Oikonen, 2009 .

ASIC-E4: Interplay of Beta-Amyloid, Synaptic Density and Neuroinflammation in Cognitively Normal Volunteers With Three Levels of Genetic Risk for Late-Onset Alzheimer's Disease – Study Protocol and Baseline Characteristics

K. Blennow, V. Oikonen, R. Parkkola, 2022, Frontiers in Neurology.

Quantifying tumour hypoxia with fluorine-18 fluoroerythronitroimidazole ([18F]FETNIM) and PET using the tumour to plasma ratio

Tove Grönroos, Heikki Minn, Vesa Oikonen, 2002, European Journal of Nuclear Medicine and Molecular Imaging.

Imaging of blood flow and hypoxia in head and neck cancer: initial evaluation with [(15)O]H(2)O and [(18)F]fluoroerythronitroimidazole PET.

V. Oikonen, H. Minn, P. Nuutila, 2001, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Resistance to exercise-induced increase in glucose uptake during hyperinsulinemia in insulin-resistant skeletal muscle of patients with type 1 diabetes.

V. Oikonen, T. Rönnemaa, P. Nuutila, 2001, Diabetes.

Enhanced stimulation of glucose uptake by insulin increases exercise-stimulated glucose uptake in skeletal muscle in humans: studies using [15O]O2, [15O]H2O, [18F]fluoro-deoxy-glucose, and positron emission tomography.

H. Sipilä, V. Oikonen, U. Ruotsalainen, 2000, Diabetes.

Myocardial blood flow and its transit time, oxygen utilization, and efficiency of highly endurance-trained human heart

H. Sipilä, V. Oikonen, J. Knuuti, 2014, Basic Research in Cardiology.

Brain Cholinergic Function and Response to Rivastigmine in Patients With Chronic Sequels of Traumatic Brain Injury: A PET Study

K. Någren, V. Oikonen, J. Rinne, 2018, The Journal of head trauma rehabilitation.

Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rats

P. Low, S. Helin, V. Oikonen, 2019, Journal of Neuroinflammation.

Positron emission tomography imaging of the 18-kDa translocator protein (TSPO) with [18F]FEMPA in Alzheimer’s disease patients and control subjects

E. Rabiner, C. Halldin, V. Oikonen, 2015, European Journal of Nuclear Medicine and Molecular Imaging.

[18F]Fluoride uptake in various bone types and soft tissues in rat

V. Oikonen, M. Haaparanta-Solin, E. Löyttyniemi, 2023, EJNMMI Research.

Measurement of Striatal and Extrastriatal Dopamine Transporter Binding with High-Resolution PET and [11C]PE2I: Quantitative Modeling and Test—Retest Reproducibility

Christer Halldin, Lars Farde, Jarkko Johansson, 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Assessment of MAO‐B Occupancy in the Brain With PET and [11C]‐L‐Deprenyl‐D2: A Dose‐Finding Study With a Novel MAO‐B Inhibitor, EVT 301

J. Hirvonen, K. Någren, H. Sipilä, 2009, Clinical pharmacology and therapeutics.

Human brown adipose tissue [15O]O2 PET imaging in the presence and absence of cold stimulus

H. Sipilä, V. Oikonen, R. Parkkola, 2016, European Journal of Nuclear Medicine and Molecular Imaging.

Correlation of 18F-FDG PET/CT assessments with disease activity and markers of inflammation in patients with early rheumatoid arthritis following the initiation of combination therapy with triple oral antirheumatic drugs

V. Oikonen, R. Parkkola, T. Möttönen, 2013, European Journal of Nuclear Medicine and Molecular Imaging.

Human Bone Marrow Adipose Tissue is a Metabolically Active and Insulin-Sensitive Distinct Fat Depot

V. Oikonen, R. Parkkola, S. Enerbäck, 2020, The Journal of clinical endocrinology and metabolism.

Insulin- and exercise-stimulated skeletal muscle blood flow and glucose uptake in obese men.

V. Oikonen, J. Knuuti, P. Nuutila, 2003, Obesity research.

Preserved relative dispersion but blunted stimulation of mean flow, absolute dispersion, and blood volume by insulin in skeletal muscle of patients with essential hypertension.

C. Cobelli, V. Oikonen, U. Ruotsalainen, 1998, Circulation.

High intensity exercise decreases global brain glucose uptake in humans

S. Aalto, V. Oikonen, J. Rinne, 2005, The Journal of physiology.

Prolonged Central μ-Opioid Receptor Occupancy after Single and Repeated Nalmefene Dosing

S. Aalto, K. Någren, J. Hietala, 2005, Neuropsychopharmacology.

Cannabinoid Type 1 Receptors Are Upregulated During Acute Activation of Brown Adipose Tissue

J. Hirvonen, V. Oikonen, P. Nuutila, 2018, Diabetes.

A Novel Positron Emission Tomography (PET) Approach to Monitor Cardiac Metabolic Pathway Remodeling in Response to Sunitinib Malate

Suzanne Gascon, J. Rousseau, R. Lecomte, 2017, PloS one.

Effect of training status on regional disposal of circulating free fatty acids in the liver and skeletal muscle during physiological hyperinsulinemia.

P. Iozzo, V. Oikonen, J. Knuuti, 2004, Diabetes care.

Cerebral acetylcholinesterase activity is not decreased in MS patients with cognitive impairment

V. Oikonen, R. Parkkola, J. Rinne, 2011, Multiple sclerosis.

Simultaneous evaluation of myocardial blood flow, cardiac function and lung water content using [15O]H2O and positron emission tomography

P. Iozzo, H. Sipilä, V. Oikonen, 2007, European Journal of Nuclear Medicine and Molecular Imaging.

Lumped constant for [(18)F]fluorodeoxyglucose in skeletal muscles of obese and nonobese humans.

V. Oikonen, J. Knuuti, P. Nuutila, 2000, American journal of physiology. Endocrinology and metabolism.

Upregulation of putaminal dopamine D2 receptors in early Parkinson's disease: a comparative PET study with [11C] raclopride and [11C]N-methylspiperone.

V Kaasinen, J O Rinne, K. Någren, 2000, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Increased density of dopamine D2 receptors in the putamen, but not in the caudate nucleus in early Parkinson's disease: a PET study with [11C]raclopride

Ulla Ruotsalainen, Kjell Någren, Juha O. Rinne, 1995, Journal of the Neurological Sciences.

Evaluation of renal glucose uptake with [18F]FDG-PET: Methodological advancements and metabolic outcomes.

V. Oikonen, E. Ferrannini, P. Nuutila, 2022, Metabolism: clinical and experimental.

Noninvasive parametric blood flow imaging of head and neck tumours using [15O]H2O and PET/CT

H. Sipilä, V. Oikonen, H. Minn, 2012, Nuclear medicine communications.

Myocardial Blood Flow and Metabolic Rate of Oxygen Measurement in the Right and Left Ventricles at Rest and During Exercise Using 15O-Labeled Compounds and PET

H. Sipilä, V. Oikonen, J. Knuuti, 2019, Front. Physiol..

Enhanced oxygen extraction and reduced flow heterogeneity in exercising muscle in endurance-trained men.

H. Sipilä, V. Oikonen, J. Knuuti, 2001, American journal of physiology. Endocrinology and metabolism.

Evaluation of 68Ga-labeled tracers for PET imaging of myocardial perfusion in pigs.

Tuula Tolvanen, Mika Teräs, Juhani Knuuti, 2012, Nuclear medicine and biology.

PET imaging of blood flow and glucose metabolism in localized musculoskeletal tumors of the extremities.

V. Oikonen, H. Minn, T. Böhling, 2011, Nuclear medicine and biology.

Quantification of liver perfusion with [(15)O]H(2)O-PET and its relationship with glucose metabolism and substrate levels.

P. Iozzo, V. Oikonen, E. Ferrannini, 2008, Journal of hepatology.

Quantification of [18F]DPA-714 binding in the human brain: initial studies in healthy controls and Alzheimer's disease patients

R. Boellaard, A. Lammertsma, R. Schuit, 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[11C]carfentanil PET imaging for studying the peripheral opioid system in vivo: effect of photoperiod on mu-opioid receptor availability in brown adipose tissue

L. Nummenmaa, S. Helin, V. Oikonen, 2022, European Journal of Nuclear Medicine and Molecular Imaging.

Measurement of central µ-opioid receptor binding in vivo with PET and [11C]carfentanil: a test–retest study in healthy subjects

Kjell Någren, Kimmo Ingman, Jussi Hirvonen, 2009, European Journal of Nuclear Medicine and Molecular Imaging.

Exercise restores skeletal muscle glucose delivery but not insulin-mediated glucose transport and phosphorylation in obese subjects.

P. Iozzo, V. Oikonen, J. Knuuti, 2006, The Journal of clinical endocrinology and metabolism.

Evidence for spatial heterogeneity in insulin- and exercise-induced increases in glucose uptake: studies in normal subjects and patients with type 1 diabetes.

O. Raitakari, V. Oikonen, T. Rönnemaa, 2001, The Journal of clinical endocrinology and metabolism.

Kinetic modeling of [(18)F]FDG in skeletal muscle by PET: a four-compartment five-rate-constant model.

C Cobelli, J Knuuti, P Nuutila, 2001, American journal of physiology. Endocrinology and metabolism.

Perfusion heterogeneity in human skeletal muscle: fractal analysis of PET data

Tuula Tolvanen, Mika Teräs, Juhani Knuuti, 2001, European Journal of Nuclear Medicine.

18F-Fluoroerythronitroimidazole radiation dosimetry in cancer studies.

V. Oikonen, H. Minn, K. Lehtiö, 2002, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer’s disease

K. Någren, V. Oikonen, J. Rinne, 2003, Journal of neurology, neurosurgery, and psychiatry.

impairment and early Alzheimer's disease Brain acetylcholinesterase activity in mild cognitive

V. Oikonen, J. Rinne, T. Kurki, 2008 .

Detection of response to COMT inhibition in FDOPA PET in advanced Parkinson's disease requires prolonged imaging

V. Oikonen, H. Ruottinen, O. Solin, 2001, Synapse.

PET studies on dopamine D1 receptors in the human brain with carbon-11-SCH 39166 and carbon-11-NNC 756.

J O Rinne, K. Någren, V. Oikonen, 1994, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[11 C]Flumazenil binding in the medial temporal lobe in patients with temporal lobe epilepsy: correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology.

M Vapalahti, J O Rinne, A. Ylinen, 2000, Neurology.

Cholinergic dysfunction after traumatic brain injury

K. Någren, V. Oikonen, J. Rinne, 2011, Neurology.

Lower abdominal adipose tissue cannabinoid type 1 receptor availability in young men with overweight

L. Nummenmaa, V. Oikonen, T. Rönnemaa, 2023, Obesity.

Preclinical Evaluation of 89Zr-Desferrioxamine-Bexmarilimab, a Humanized Antibody Against Common Lymphatic Endothelial and Vascular Endothelial Receptor-1, in a Rabbit Model of Renal Fibrosis

V. Oikonen, P. Taimen, S. Jalkanen, 2022, The Journal of Nuclear Medicine.

Striatal [18F]fluorodopa utilization after COMT inhibition with entacapone studied with PET in advanced Parkinson's disease

V. Oikonen, J. Rinne, U. Ruotsalainen, 1995, Journal of neural transmission. Parkinson's disease and dementia section.

(2S, 4R)-4-[18F]Fluoroglutamine for In vivo PET Imaging of Glioma Xenografts in Mice: an Evaluation of Multiple Pharmacokinetic Models

V. Oikonen, J. Westermarck, H. Liljenbäck, 2020, Molecular Imaging and Biology.

Evidence for Dissociation of Insulin Stimulation of Blood Flow and Glucose Uptake in Human Skeletal Muscle: Studies Using [15O]H2O, [18F]fluoro-2-deoxy-D-glucose, and Positron Emission Tomography

H. Sipilä, V. Oikonen, J. Knuuti, 1996, Diabetes.

Kinetic Modelling of [68Ga]Ga-DOTA-Siglec-9 in Porcine Osteomyelitis and Soft Tissue Infections

V. Oikonen, A. Alstrup, S. Jalkanen, 2019, Molecules.

Automated Reference Region Extraction and Population-Based Input Function for Brain [11C]TMSX PET Image Analyses

Jarkko Johansson, Eveliina Arponen, Riitta Parkkola, 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

68Ga-DOTA chelate, a novel imaging agent for assessment of myocardial perfusion and infarction detection in a rodent model

S. Helin, V. Oikonen, J. Knuuti, 2019, Journal of Nuclear Cardiology.

Myocardial blood flow, oxygen consumption, and fatty acid uptake in endurance athletes during insulin stimulation.

V. Oikonen, J. Knuuti, U. Ruotsalainen, 1999, American journal of physiology. Endocrinology and metabolism.

Myocardial blood flow, oxygen consumption, and fatty acid uptake in endurance athletes during insulin stimulation.

V. Oikonen, J. Knuuti, U. Ruotsalainen, 1999, The American journal of physiology.

Acute effects of celiprolol on muscle blood flow and insulin sensitivity: studies using [15O]-water, [18F]-fluorodeoxyglucose and positron emission tomography

V. Oikonen, U. Ruotsalainen, P. Nuutila, 1997, European Journal of Clinical Pharmacology.

FDOPA PET : Literature review

V. Oikonen, 2005 .

Measurement of extrastriatal D2-like receptor binding with [11C]FLB 457 – a test-retest analysis

Kjell Någren, Jarmo Hietala, Vesa Oikonen, 2000, European Journal of Nuclear Medicine.

Quantitative brain imaging using the new, fast iterative histogram-mode reconstruction for the HRRT PET scanner

M. Teras, J. Johansson, V. Oikonen, 2007, 2007 IEEE Nuclear Science Symposium Conference Record.

11C-ORM-13070, a novel PET ligand for brain α2C-adrenoceptors: radiometabolism, plasma pharmacokinetics, whole-body distribution and radiation dosimetry in healthy men

Eveliina Arponen, Semi Helin, Jukka Sallinen, 2014, European Journal of Nuclear Medicine and Molecular Imaging.

Evaluation of [11C]ORM-13070 as a PET tracer for α2C-adrenoceptors in the human brain

C. Halldin, V. Oikonen, M. Scheinin, 2014 .

Myocardial blood flow and adenosine A2A receptor density in endurance athletes and untrained men

S. Nesterov, K. Någren, V. Oikonen, 2008, The Journal of physiology.

Alfentanil increases cortical dopamine D2/D3 receptor binding in healthy subjects

Kjell Någren, Jarmo Hietala, Vesa Oikonen, 2004, Pain.

Striatal 6‐[18F]fluorodopa accumulation after combined inhibition of peripheral catechol‐O‐methyltransferase and monoamine oxidase type B: Differing response in relation to presynaptic dopaminergic dysfunction

V. Oikonen, J. Rinne, U. Ruotsalainen, 1997, Synapse.

A PET Study on the Acute Effect of Ethanol on Striatal D2 Dopamine Receptors with [11C]Raclopride in Healthy Males

Ulla Ruotsalainen, Kjell Någren, Jarmo Hietala, 1997 .

Parametric renal blood flow imaging using [15O]H2O and PET

Tuula Tolvanen, Hidehiro Iida, Nobuyuki Kudomi, 2009, European Journal of Nuclear Medicine and Molecular Imaging.

Voxel-based NK1 Receptor Occupancy Measurements with [18F]SPA-RQ and Positron Emission Tomography: A Procedure for Assessing Errors from Image Reconstruction and Physiological Modeling

Ulla Ruotsalainen, Jarmo Hietala, Vesa Oikonen, 2007, Molecular Imaging and Biology.

Reproducibility of Striatal and Thalamic Dopamine D2 Receptor Binding Using [11C]raclopride with High-Resolution Positron Emission Tomography

Matti Laine, Kjell Någren, Vesa Oikonen, 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Pulmonary blood flow and its distribution in highly trained endurance athletes and healthy control subjects.

V. Oikonen, J. Knuuti, J. Kemppainen, 2013, Journal of applied physiology.

Effects of metformin and rosiglitazone monotherapy on insulin-mediated hepatic glucose uptake and their relation to visceral fat in type 2 diabetes.

P. Iozzo, V. Oikonen, R. Parkkola, 2003, Diabetes care.

Regulation of human brown adipose tissue by adenosine and A2A receptors – studies with [15O]H2O and [11C]TMSX PET/CT

S. Helin, V. Oikonen, P. Nuutila, 2018, European Journal of Nuclear Medicine and Molecular Imaging.

Extraction of Input Function from Rat [18F]FDG PET Images

P. Iozzo, V. Oikonen, P. Nuutila, 2011, Molecular Imaging and Biology.

RESEARCH ARTICLE Extraction of Input Function from Rat ( 18 F)FDG PET Images

P. Iozzo, V. Oikonen, P. Nuutila, 2011 .

Increased Brain Fatty Acid Uptake in Metabolic Syndrome

P. Iozzo, J. Hirvonen, K. Någren, 2010, Diabetes.