D. Praticò

G. FitzGerald, D. Praticò, S. Basili, 1998, Journal of investigative medicine : the official publication of the American Federation for Clinical Research.

BM-520, an original TXA2 modulator, inhibits the action of thromboxane A2 and 8-iso-prostaglandin F2alphain vitro and in vivo on human and rodent platelets, and aortic vascular smooth muscles from rodents.

D. Praticò, B. Masereel, S. Rolin, 2007, Prostaglandins & other lipid mediators.

8‐Epi PGF2α: specific analysis of an isoeicosanoid as an index of oxidant stress in vivo

G. FitzGerald, D. Praticò, N. Delanty, 2003 .

8-Epi PGF2 alpha: specific analysis of an isoeicosanoid as an index of oxidant stress in vivo.

M. Reilly, G. FitzGerald, D. Praticò, 1996, British journal of clinical pharmacology.

Cellular Activation of Thromboxane Receptors a

G. FitzGerald, D. Praticò, J. Lawson, 1994, Annals of the New York Academy of Sciences.

Engagement of human PECAM-1 (CD31) on human endothelial cells increases intracellular calcium ion concentration and stimulates prostacyclin release.

I. Gurubhagavatula, D. Praticò, R. Panettieri, 1998, The Journal of clinical investigation.

PGHS-2 Dependent Formation of 8-Epi PGF2α by Human Monocytes

G. FitzGerald, D. Praticò, 1996 .

Reaction of dipyridamole with the hydroxyl radical

D. Praticò, F. Violi, L. Iuliano, 1992, Lipids.

Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor

D. Praticò, E. Lauretti, A. D. Meco, 2015, Neurobiology of Aging.

Zileuton restores memory impairments and reverses amyloid and tau pathology in aged AD mice

D. Praticò, E. Lauretti, A. D. Meco, 2014 .

Platelet activation by superoxide anion and hydroxyl radicals intrinsically generated by platelets that had undergone anoxia and then reoxygenated.

G. FitzGerald, D. Praticò, F. Violi, 1997, Circulation.

Polymorphonuclear leukocyte-derived O2-reactive species activate primed platelets in human whole blood.

D. Praticò, C. Alessandri, F. Violi, 1993, The American journal of physiology.

Superoxide dismutase triggers activation of "primed" platelets.

D. Praticò, F. Violi, L. Iuliano, 1991, Archives of biochemistry and biophysics.

Dysfunction of the retromer complex system contributes to amyloid and tau pathology in a stem cell model of Down syndrome

D. Praticò, B. Blass, Tiffany Smith, 2022, Alzheimer's & dementia.

Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease.

D. Praticò, Y. Joshi, J. Chu, 2012, Journal of Alzheimer's disease : JAD.

Thrombocytopenia and thrombocytopathia in liver cirrhosis

G. Davı̀, D. Praticò, F. Violi, 1992 .

8-epi PGF2 alpha generation during coronary reperfusion. A potential quantitative marker of oxidant stress in vivo.

M. Reilly, G. FitzGerald, D. Praticò, 1997, Circulation.

ER stress and UPR in Alzheimer’s disease: mechanisms, pathogenesis, treatments

D. Praticò, Amir Ajoolabady, Jun Ren, 2022, Cell Death & Disease.

Pharmacological modulation of GSAP reduces amyloid-β levels and tau phosphorylation in a mouse model of Alzheimer's disease with plaques and tangles.

D. Praticò, C. Craige, E. Lauretti, 2014, Journal of Alzheimer's disease : JAD.

Lower CSF amyloid beta peptides and higher F2-isoprostanes in cognitively intact elderly individuals with major depressive disorder.

K. Blennow, J. Sidtis, J. Nierenberg, 2012, The American journal of psychiatry.

Memory Decline in Down Syndrome and Its Relationship to iPF2alpha, a Urinary Marker of Oxidative Stress

A. McQuillin, D. Praticò, Z. Walker, 2014, PloS one.

Formation of 8-iso-Prostaglandin F2α by Human Platelets

G. FitzGerald, D. Praticò, N. Delanty, 1995 .

Formation of 8-iso-prostaglandin F2 alpha by human platelets.

G. FitzGerald, D. Praticò, N. Delanty, 1995, Agents and actions. Supplements.

Oxidative stress and cognitive ability in adults with Down syndrome

D. Praticò, Z. Walker, A. Strydom, 2009, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Learning Impairments, Memory Deficits, and Neuropathology in Aged Tau Transgenic Mice Are Dependent on Leukotrienes Biosynthesis: Role of the cdk5 Kinase Pathway

D. Praticò, P. Giannopoulos, Jian Chiu, 2018, Molecular Neurobiology.

Degradation of gamma secretase activating protein by the ubiquitin–proteasome pathway

D. Praticò, M. Madesh, Jian-guo Li, 2015, Journal of neurochemistry.

Superoxide Anion and Hydroxyl Radical Release by Collagen-induced Platelet Aggregation - Role of Arachidonic Acid Metabolism

D. Praticò, F. Violi, L. Iuliano, 2000, Thrombosis and Haemostasis.

The contribution of altered neuronal autophagy to neurodegeneration.

D. Praticò, E. Esposito, N. Lyssenko, 2022, Pharmacology & therapeutics.

The isoprostanes in biology and medicine

G. FitzGerald, D. Praticò, J. Lawson, 2001, Trends in Endocrinology & Metabolism.

Functional relevance of the expression of ligand-induced binding sites in the response to platelet GP IIb/IIIa antagonists in vivo.

D. Praticò, D. Fitzgerald, N. Murphy, 1998, The Journal of pharmacology and experimental therapeutics.

Free radical-mediated platelet activation by hemoglobin released from red blood cells.

D. Praticò, G. Rotilio, F. Violi, 1992, Archives of biochemistry and biophysics.

Inhibition by picotamide of thromboxane production in vitro and ex vivo

D. Praticò, C. Alessandri, F. Violi, 2004, European Journal of Clinical Pharmacology.

Inhibition of cyclooxygenase-independent platelet aggregation by low vitamin E concentration.

D. Praticò, C. Alessandri, C. Cordova, 1990, Atherosclerosis.

The 12/15Lipoxygenase as an emerging therapeutic target for Alzheimer's disease

D. Praticò, P. Giannopoulos, Y. Joshi, 2015 .

QTC-4-MeOBnE rescues scopolamine-induced memory deficits in mice by targeting oxidative stress, neuronal plasticity and apoptosis.

D. Praticò, L. Savegnago, T. Collares, 2020, ACS chemical neuroscience.

Early‐life exposure to high‐fat diet influences brain health in aging mice

D. Praticò, A. Di Meco, 2019, Aging cell.

Disruption of Phospholipid Transfer Protein–Mediated High-Density Lipoprotein Maturation Reduces Scavenger Receptor BI Deficiency–Driven Atherosclerosis Susceptibility Despite Unexpected Metabolic Complications

D. Praticò, M. Jauhiainen, T. V. van Berkel, 2020, Arteriosclerosis, thrombosis, and vascular biology.

Fluorescence quenching of dipyridamole associated to peroxyl radical scavenging: a versatile probe to measure the chain breaking antioxidant activity of biomolecules.

D. Praticò, F. Violi, L. Iuliano, 2000, Biochimica et biophysica acta.

A role for 12/15 lipoxygenase in the amyloid beta precursor protein metabolism.

D. Praticò, Francesca Succol, 2007, Journal of neurochemistry.

Gestational oxidative stress protects against adult obesity and insulin resistance

D. Praticò, H. Verkade, T. Plösch, 2019, Redox biology.

Beneficial Effect of a Small Pharmacologic Chaperone on the Established Alzheimer's Disease Phenotype.

D. Praticò, Jian-guo Li, B. Blass, 2022, Journal of Alzheimer's disease : JAD.

Extra-Virgin Olive Oil Enhances the Blood–Brain Barrier Function in Mild Cognitive Impairment: A Randomized Controlled Trial

T. Denney, R. Beyers, G. Deshpande, 2022, Nutrients.

Elevated cerebrospinal fluid F2-isoprostane levels indicating oxidative stress in healthy siblings of multiple sclerosis patients

K. Blennow, D. Praticò, H. Zetterberg, 2007, Neuroscience Letters.

The Role of Biomarkers in Clinical Trials for Alzheimer Disease

Eric M Reiman, Henrik Zetterberg, Kejal Kantarci, 2006, Alzheimer disease and associated disorders.

Novel Key Players in the Development of Tau Neuropathology: Focus on the 5-Lipoxygenase.

D. Praticò, E. Lauretti, 2018, Journal of Alzheimer's disease : JAD.

Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease.

J. Trojanowski, C. Clark, V. Lee, 2002, Archives of neurology.

Oxidative stress hypothesis in Alzheimer's disease: a reappraisal.

D. Praticò, 2008, Trends in pharmacological sciences.

Oxygen free radicals and platelet activation.

D. Praticò, F. Violi, L. Iuliano, 1997, Free radical biology & medicine.

Adverse cardiovascular effects of the coxibs.

D. Praticò, C. Supuran, J. Dogné, 2005, Journal of medicinal chemistry.

A new synthetic approach for 4(S)-hydroxycyclopent-2-enone: a precursor to prostanoid synthesis

G. FitzGerald, D. Praticò, J. Lawson, 2005 .

Evidence of Oxidative Stress in Alzheimer's Disease Brain and Antioxidant Therapy

D. Praticò, Domenico Praticò, 2008, Annals of the New York Academy of Sciences.

12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice

D. Praticò, Jian-guo Li, M. Abou-Gharbia, 2017, Biological Psychiatry.

Role of hydroxyl radicals in the activation of human platelets.

D. Praticò, G. Rotilio, F. Violi, 1994, European journal of biochemistry.

Increased F2‐isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo

J. Trojanowski, G. FitzGerald, D. Praticò, 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Chronic obstructive pulmonary disease is associated with an increase in urinary levels of isoprostane F2alpha-III, an index of oxidant stress.

G. FitzGerald, D. Praticò, S. Basili, 1998, American journal of respiratory and critical care medicine.

N‐acetylcysteine targets 5 lipoxygenase‐derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice

S. Carmichael, G. Coppola, T. Holman, 2018, Annals of neurology.

Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD.

D. Praticò, J. Lambris, P. Hahn, 2008, Investigative ophthalmology & visual science.

Elevated levels of brain homocysteine directly modulates the pathological phenotype of a mouse model of tauopathy

S. Merali, D. Praticò, Jian-guo Li, 2018, Molecular Psychiatry.

The neurobiology of non-coding RNAs and Alzheimer’s disease pathogenesis: Pathways, mechanisms and translational opportunities

K. Dąbrowski, D. Praticò, E. Lauretti, 2021, Ageing Research Reviews.

The Functional Role of microRNAs in the Pathogenesis of Tauopathy

D. Praticò, 2020, Cells.

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

D. Praticò, P. Jadiya, D. Tomar, 2019, Nature Communications.

The contribution of altered neuronal autophagy to neurodegeneration.

D. Praticò, E. Esposito, N. Lyssenko, 2022, Pharmacology & therapeutics.

Dysregulation of the Retromer Complex in Brain Endothelial Cells Results in Accumulation of Phosphorylated Tau

D. Praticò, Tiffany Smith, A. Filippone, 2021, Journal of inflammation research.

VPS35 Downregulation Alters Degradation Pathways in Neuronal Cells.

D. Praticò, Jian-guo Li, A. Filippone, 2021, Journal of Alzheimer's disease : JAD.

Overexpression of 5-Lipoxygenase Worsens the Phenotype of a Mouse Model of Tauopathy

D. Praticò, P. Giannopoulos, 2017, Molecular Neurobiology.

Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis

J. Trojanowski, V. Lee, D. Praticò, 2004, Journal of Neuroinflammation.

Zileuton Improves Memory Deficits, Amyloid and Tau Pathology in a Mouse Model of Alzheimer’s Disease with Plaques and Tangles

D. Praticò, J. Chu, Jin-guo Li, 2013, PloS one.

Altered vascular phenotype in autism: correlation with oxidative stress.

William J Walsh, W. J. Walsh, D. Praticò, 2006, Archives of neurology.

CXCR4 on human endothelial cells can serve as both a mediator of biological responses and as a receptor for HIV-2.

J. Hoxie, D. Praticò, N. Prévost, 2000, Biochimica et biophysica acta.

Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?

Jia-min Zhuo, D. Praticò, Hong Wang, 2011, Trends in pharmacological sciences.

Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease.

J. Trojanowski, V. Lee, D. Praticò, 2004, The American journal of pathology.

Glycogen synthase kinase-3 signaling in Alzheimer's disease.

D. Praticò, E. Lauretti, Ozlem Dincer, 2020, Biochimica et biophysica acta. Molecular cell research.

HEMOSTASIS , THROMBOSIS , AND VASCULAR BIOLOGY Vitamin E Reduces Monocyte Tissue Factor Expression in Cirrhotic Patients

G. FitzGerald, D. Praticò, S. Basili, 1999 .

Homocysteine exacerbates β‐amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles

S. Merali, D. Praticò, Jian-guo Li, 2014, Annals of neurology.

Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's disease.

Jia-min Zhuo, D. Praticò, W. Kruger, 2009, Current Alzheimer research.

Organelle Crosstalk Regulators Are Regulated in Diseases, Tumors, and Regulatory T Cells: Novel Classification of Organelle Crosstalk Regulators

D. Praticò, Xiaofeng Yang, Jianxin Sun, 2021, Frontiers in Cardiovascular Medicine.

Peripheral biomarkers of oxidative damage in Alzheimer's disease: the road ahead

D. Praticò, 2005, Neurobiology of Aging.

Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury

J. Trojanowski, V. Lee, D. Praticò, 2004, Journal of neurochemistry.

National scientific medical meeting 1995 abstracts

G. R. Fitzgerald, W. K. Cullen, M. Rowan, 1995, Irish journal of medical science.

Gamma Secretase-Activating Protein Is a Substrate for Caspase-3: Implications for Alzheimer’s Disease

D. Praticò, M. Madesh, Jian-guo Li, 2015, Biological Psychiatry.

GATA1‐mediated transcriptional regulation of the γ‐secretase activating protein increases Aβ formation in Down syndrome

T. Wisniewski, D. Praticò, J. Chu, 2016, Annals of neurology.

Enhanced monocyte expression of tissue factor by oxidative stress in patients with antiphospholipid antibodies: effect of antioxidant treatment

G. FitzGerald, D. Praticò, Y. Shoenfeld, 2003, Journal of thrombosis and haemostasis : JTH.

ABCA7 and the altered lipidostasis hypothesis of Alzheimer's disease

D. Praticò, N. Lyssenko, 2020, Alzheimer's & dementia : the journal of the Alzheimer's Association.

Effect of Low-Dose Aspirin on Vascular Inflammation, Plaque Stability, and Atherogenesis in Low-Density Lipoprotein Receptor–Deficient Mice

D. Praticò, Lei Zhao, C. Funk, 2002, Circulation.

and Domenico Praticò Deficient Mice − in Low-Density Lipoprotein Receptor Effect of Low-Dose Aspirin on Vascular Inflammation , Plaque Stability , and Atherogenesis

D. Praticò, Lei Zhao, C. Funk, 2002 .

Studies on Alzheimer's Disease

P. Mecocci, D. Praticò, 2013, Oxidative Stress in Applied Basic Research and Clinical Practice.

Extra virgin olive oil improves synaptic activity, short‐term plasticity, memory, and neuropathology in a tauopathy model

D. Praticò, L. Iuliano, M. Nenov, 2019, Aging cell.

Extra‐virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy

D. Praticò, L. Iuliano, E. Lauretti, 2017, Annals of clinical and translational neurology.

Platelet-derived microparticles stimulate proliferation, survival, adhesion, and chemotaxis of hematopoietic cells.

D. Praticò, M. Ratajczak, G. Vilaire, 2002, Experimental hematology.

Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease.

J. Trojanowski, V. Lee, D. Praticò, 2004, The American journal of pathology.

The 5-Lipoxygenase as modulator of Alzheimer’s γ-secretase and therapeutic target

D. Praticò, J. Chu, 2016, Brain Research Bulletin.

Low‐dose oral sirolimus reduces atherogenesis, vascular inflammation and modulates plaque composition in mice lacking the LDL receptor

D. Praticò, R. Falotico, M. Ma, 2009, British journal of pharmacology.

Autophagy Dysfunction in Alzheimer’s Disease: Mechanistic Insights and New Therapeutic Opportunities

D. Praticò, E. Lauretti, M. Curtis, 2020, Biological Psychiatry.

5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5

D. Praticò, J. Chu, 2013, Neurobiology of Aging.

The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease

K. Blennow, S. Santi, L. Mosconi, 2009, Neurobiology of Aging.

Sex-specific neurogenic deficits and neurocognitive disorders in middle-aged HIV-1 Tg26 transgenic mice

D. Praticò, M. Barbe, Huaqing Zhao, 2019, Brain, Behavior, and Immunity.

Oxidative imbalance and lipid peroxidation in Alzheimer's disease

D. Praticò, 2002 .

Normalization of hyperhomocysteinemia improves cognitive deficits and ameliorates brain amyloidosis of a transgenic mouse model of Alzheimer's disease

Jia-min Zhuo, D. Praticò, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Localization of distinct F2-isoprostanes in human atherosclerotic lesions.

G. FitzGerald, D. Praticò, J. Lawson, 1997, The Journal of clinical investigation.

Chapter 2 – Alzheimer’s Disease

D. Praticò, P. Giannopoulos, 2015 .

Early Vitamin E supplementation in young but not aged mice reduces Aβ levels and amyloid deposition in a transgenic model of Alzheimer's disease

J. Trojanowski, V. Lee, D. Praticò, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Selective Interleukin-12 Synthesis Defect in 12/15-Lipoxygenase-deficient Macrophages Associated with Reduced Atherosclerosis in a Mouse Model of Familial Hypercholesterolemia*

D. Rader, E. Puré, E. Klein, 2002, The Journal of Biological Chemistry.

Dissecting the Role of 5-Lipoxygenase in the Homocysteine-Induced Alzheimer’s Disease Pathology

D. Praticò, Jian-guo Li, A. Di Meco, 2017, Journal of Alzheimer's disease : JAD.

Increased F2 isoprostane plasma levels in patients with congestive heart failure are correlated with antioxidant status and disease severity.

P. Mecocci, D. Praticò, M. Polidori, 2004, Journal of cardiac failure.

NADPH oxidase mediates hypersomnolence and brain oxidative injury in a murine model of sleep apnea.

E. Klann, D. Praticò, F. Serrano, 2005, American journal of respiratory and critical care medicine.

Thromboxane receptor blockade improves the antiatherogenic effect of thromboxane A2 suppression in LDLR KO mice.

D. Praticò, J. Dogné, T. Cyrus, 2007, Blood.

Macrophage-specific expression of group IIA sPLA2 results in accelerated atherogenesis by increasing oxidative stress Published, JLR Papers in Press, May 16, 2005. DOI 10.1194/jlr.M400469-JLR200

D. Praticò, T. V. van Berkel, C. Funk, 2005, Journal of Lipid Research.

Absence of 12/15-Lipoxygenase Expression Decreases Lipid Peroxidation and Atherogenesis in Apolipoprotein E—Deficient Mice

D. Rader, G. FitzGerald, D. Praticò, 2001, Circulation.

Acceleration of brain amyloidosis in an Alzheimer’s disease mouse model by a folate, vitamin B6 and B12-deficient diet

Jia-min Zhuo, D. Praticò, 2010, Experimental Gerontology.

Hypometabolism and Altered Cerebrospinal Fluid Markers in Normal Apolipoprotein E E4 Carriers with Subjective Memory Complaints

Mony J. de Leon, Lisa Mosconi, Elizabeth Pirraglia, 2008, Biological Psychiatry.

The 5-lipoxygenase enzymatic pathway in the mouse brain: Young versus old

D. Praticò, C. Chinnici, Yuemang Yao, 2007, Neurobiology of Aging.

Glucose deprivation increases tau phosphorylation via P38 mitogen‐activated protein kinase

D. Praticò, Domenico Praticò, Elisabetta Lauretti, 2015, Aging cell.

Thromboxane Receptor Activation Mediates Isoprostane-Induced Increases in Amyloid Pathology in Tg2576 Mice

Bin Zhang, V. Lee, D. Praticò, 2008, The Journal of Neuroscience.

From the design to the clinical application of thromboxane modulators.

Bernard Pirotte, Pierre Drion, D. Praticò, 2006, Current pharmaceutical design.

QTC-4-MeOBnE Ameliorated Depressive-Like Behavior and Memory Impairment in 3xTg Mice

D. Praticò, L. Savegnago, Mariana G. Fronza, 2022, Molecular Neurobiology.

Effect of canola oil consumption on memory, synapse and neuropathology in the triple transgenic mouse model of Alzheimer’s disease

D. Praticò, E. Lauretti, 2017, Scientific Reports.

Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer’s phenotype

S. Merali, D. Praticò, Jian-guo Li, 2017, Scientific Reports.

Homocysteine modulates 5‐lipoxygenase expression level via DNA methylation

S. Merali, D. Praticò, Jian-guo Li, 2016, Aging cell.

Zileuton restores memory impairments and reverses amyloid and tau pathology in aged Alzheimer's disease mice

D. Praticò, E. Lauretti, A. D. Meco, 2014, Neurobiology of Aging.

Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease.

D. Praticò, L. Kirby, M. Abood, 2014, Human molecular genetics.

Modulation of lipopolysaccharide-induced memory insult, γ-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase

D. Praticò, Y. Joshi, P. Giannopoulos, 2014, Neurobiology of Aging.

Novel lipid signaling pathways in Alzheimer's disease pathogenesis.

D. Praticò, Domenico Praticò, Phillip F Giannopoulos, 2014, Biochemical pharmacology.

Gene Knockout of 5-Lipoxygenase Rescues Synaptic Dysfunction and Improves Memory in the Triple-Transgenic Model of Alzheimer’s Disease

D. Praticò, L. Kirby, Y. Joshi, 2013, Molecular Psychiatry.

FLAP pharmacological blockade modulates metabolism of endogenous tau in vivo

D. Praticò, J Chu, E Lauretti, 2013, Translational Psychiatry.

5-Lipoxygenase Activating Protein Reduction Ameliorates Cognitive Deficit, Synaptic Dysfunction, and Neuropathology in a Mouse Model of Alzheimer’s Disease

D. Praticò, L. Kirby, Y. Joshi, 2013, Biological Psychiatry.

Knockout of 5‐lipoxygenase prevents dexamethasone‐induced tau pathology in 3xTg mice

D. Praticò, Yash B. Joshi, Jin Chu, 2013, Aging cell.

5‐Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of alzheimer disease

D. Praticò, T. Golde, C. Ceballos‐Diaz, 2012, Annals of neurology.

Repetitive Mild Brain Trauma Accelerates Aβ Deposition, Lipid Peroxidation, and Cognitive Impairment in a Transgenic Mouse Model of Alzheimer Amyloidosis

J. Trojanowski, V. Lee, D. Praticò, 2002, The Journal of Neuroscience.

Increased Lipid Peroxidation Precedes Amyloid Plaque Formation in an Animal Model of Alzheimer Amyloidosis

Virginia M. Y. Lee, D. Praticò, K. Uryu, 2001, The Journal of Neuroscience.

Full recovery of the Alzheimer’s disease phenotype by gain of function of Vacuolar Protein Sorting 35

D. Praticò, Jian-guo Li, Jin Chiu, 2019, Molecular Psychiatry.

The retromer complex system in a transgenic mouse model of AD: influence of age

D. Praticò, J. Chu, 2017, Neurobiology of Aging.

1-(7-Chloroquinolin-4-yl)-N-(4-Methoxybenzyl)-5-Methyl-1H-1,2, 3-Triazole-4- carboxamide Reduces Aβ Formation and Tau Phosphorylation in Cellular Models of Alzheimer’s Disease

D. Praticò, L. Savegnago, Mariana G. Fronza, 2022, Neurochemical Research.

Effect of QTC-4-MeOBnE Treatment on Memory, Neurodegeneration, and Neurogenesis in a Streptozotocin-Induced Mouse Model of Alzheimer's Disease.

D. Praticò, L. Savegnago, T. Collares, 2020, ACS chemical neuroscience.

Amyloid precursor protein and amyloid beta peptide in human platelets. Role of cyclooxygenase and protein kinase C.

D. Skovronsky, D. Praticò, V. Lee, 2001, The Journal of biological chemistry.

Glucose deficit triggers tau pathology and synaptic dysfunction in a tauopathy mouse model

D. Praticò, J-G Li, E. Lauretti, 2017, Translational Psychiatry.

Pharmacologic Inhibition of 5-Lipoxygenase Improves Memory, Rescues Synaptic Dysfunction, and Ameliorates Tau Pathology in a Transgenic Model of Tauopathy

D. Praticò, Jian-guo Li, L. Kirby, 2015, Biological Psychiatry.

Endosome Dysregulation in Down Syndrome: A Potential Contributor to Alzheimer Disease Pathology

D. Praticò, A. Filippone, 2021, Annals of neurology.

The Influence of 5-Lipoxygenase on Alzheimer’s Disease-Related Tau Pathology: In Vivo and In Vitro Evidence

D. Praticò, T. Golde, Jian-guo Li, 2013, Biological Psychiatry.

A role for 12/15 lipoxygenase in the amyloid β precursor protein metabolism

D. Praticò, Francesca Succol, 2007 .

The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimer’s disease phenotype

D. Praticò, Y. Joshi, 2015, Front. Cell. Neurosci..

Biochemical markers in persons with preclinical familial Alzheimer disease

D. Geschwind, J. Cummings, J. Ringman, 2008, Neurology.

Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti‐inflammatory drugs

D. Praticò, K. Townsend, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Amyloid Precursor Protein and Amyloid b Peptide in Human Platelets ROLE OF CYCLOOXYGENASE AND PROTEIN KINASE C *

D. Skovronsky, D. Praticò, V. Lee, 2001 .

Angioplasty increases coronary sinus F2-isoprostane formation: evidence for in vivo oxidative stress during PTCA.

G. FitzGerald, D. Praticò, F. Violi, 2001, Journal of the American College of Cardiology.

Coxibs and Alzheimer's disease: Should they stay or should they go?

D. Praticò, O. Firuzi, 2006, Annals of neurology.

Oxidative Stress in the Development of Alzheimer’s Disease and Other Dementias

D. Praticò, 2004 .

Iron-dependent human platelet activation and hydroxyl radical formation: involvement of protein kinase C.

G. FitzGerald, D. Praticò, F. Violi, 1999, Circulation.

Additive anti-atherogenic effect of thromboxane receptor antagonism with 12/15lipoxygenase gene disruption in apolipoprotein E-deficient mice.

D. Praticò, T. Ding, L. Tang, 2008, Atherosclerosis.

Prostanoids, Their Receptors, and Atherogenesis

D. Praticò, 2015 .

thromboxane A2 suppression in LDLR KO mice Thromboxane receptor blockade improves the antiatherogenic effect of

D. Praticò, J. Dogné, T. Cyrus, 2013 .

suppression in LDLR KO mice 2 thromboxane A Thromboxane receptor blockade improves the antiatherogenic effect of

D. Praticò, J. Dogné, T. Cyrus, 2010 .

Vascular biology of eicosanoids and atherogenesis

D. Praticò, J. Dogné, 2009, Expert review of cardiovascular therapy.

Prostanoid and isoprostanoid pathways in atherogenesis.

D. Praticò, 2008, Atherosclerosis.

A novel thromboxane receptor antagonist and synthase inhibitor, BM-573, reduces development and progression of atherosclerosis in LDL receptor deficient mice.

D. Praticò, J. Dogné, T. Cyrus, 2007, European journal of pharmacology.

Stabilization of advanced atherosclerosis in low-density lipoprotein receptor-deficient mice by aspirin.

D. Praticò, T. Cyrus, Yuemang Yao, 2006, Atherosclerosis.

Involvement of Thromboxane Receptor in the Proatherogenic Effect of Isoprostane F2&agr;-III: Evidence From Apolipoprotein E– and LDL Receptor–Deficient Mice

D. Praticò, T. Cyrus, Yuemang Yao, 2005, Circulation.

Selective Cyclooxygenase-2 Inhibitors Development in Cardiovascular Medicine

D. Praticò, J. Dogné, 2005, Circulation.

COX-2–Dependent Cardiac Failure in Gh/tTG Transgenic Mice

M. Sutton, P. McNamara, G. FitzGerald, 2003, Circulation research.

Genetic absence of ALOX5 protects from homocysteine‐induced memory impairment, tau phosphorylation and synaptic pathology

S. Merali, D. Praticò, Jian-guo Li, 2017, Human molecular genetics.

Transcriptional regulation of βsecretase‐1 by 12/15‐lipoxygenase results in enhanced amyloidogenesis and cognitive impairments

Jia-min Zhuo, D. Praticò, J. Chu, 2012, Annals of neurology.

Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice

D. Praticò, T. Golde, C. Ceballos‐Diaz, 2012, Molecular Neurodegeneration.

High-dose B vitamin supplements and Alzheimer disease.

D. Praticò, 2009, JAMA.

iPF2α-III-17,18,19,20-d4: Total synthesis and metabolism

G. FitzGerald, D. Praticò, J. Lawson, 2005 .

Increased 8,12‐iso‐iPF2α‐VI in Alzheimer's disease: Correlation of a noninvasive index of lipid peroxidation with disease severity

J. Trojanowski, C. Clark, V. Lee, 2000, Annals of neurology.

Endogenous biosynthesis of thromboxane and prostacyclin in 2 distinct murine models of atherosclerosis.

G. FitzGerald, D. Praticò, H. Li, 2000, Blood.

Oxidative Stress and Amyloid-Beta Pathology in Normal Individuals with A Maternal History of Alzheimer's

Rachel L. Mistur, K. Blennow, S. Santi, 2010, Biological Psychiatry.

Imaging and CSF Studies in the Preclinical Diagnosis of Alzheimer's Disease

K. Blennow, M. J. Leon, H. Rusinek, 2007, Annals of the New York Academy of Sciences.

Alzheimer's disease and the quest for its biological measures.

D. Praticò, 2012, Journal of Alzheimer's disease : JAD.

Oxidative Stress and Amyloid-Beta Pathology in Normal Individuals with A Maternal History of

Rachel L. Mistur, K. Blennow, S. Santi, 2010 .

Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment

K. Blennow, S. Santi, L. Mosconi, 2009, Neurobiology of Aging.

Magnetic resonance imaging improves cerebrospinal fluid biomarkers in the early detection of Alzheimer's disease.

K. Blennow, H. Rusinek, S. de Santi, 2009, Journal of Alzheimer's disease : JAD.

Inducible nitric oxide synthase in long-term intermittent hypoxia: hypersomnolence and brain injury.

D. Praticò, S. Veasey, G. Zhan, 2005, American journal of respiratory and critical care medicine.

Long-term intermittent hypoxia in mice: protracted hypersomnolence with oxidative injury to sleep-wake brain regions.

D. Praticò, S. Veasey, G. Zhan, 2004, Sleep.

Circulating autoantibodies to oxidized cardiolipin correlate with isoprostane F(2alpha)-VI levels and the extent of atherosclerosis in ApoE-deficient mice: modulation by vitamin E.

G. FitzGerald, D. Praticò, R. Tangirala, 2001, Blood.

Localization of Distinct F 2 -Isoprostanes in Human Atherosclerotic Lesions

G. FitzGerald, D. Praticò, J. Lawson, 1997 .

Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics.

D. Klionsky, V. Uversky, G. Kroemer, 2021, Pharmacology & therapeutics.

F(2)-isoprostanes: sensitive and specific non-invasive indices of lipid peroxidation in vivo.

D. Praticò, 1999, Atherosclerosis.

High levels of homocysteine results in cerebral amyloid angiopathy in mice.

D. Praticò, Jian-guo Li, 2014, Journal of Alzheimer's disease : JAD.

Hydrogen peroxide as trigger of platelet aggregation.

D. Praticò, C. Alessandri, F. Violi, 1991, Haemostasis.

12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress.

J. Trojanowski, V. Lee, D. Praticò, 2004, The American journal of pathology.

Increase in peripheral oxidative stress during hypercholesterolemia is not reflected in the central nervous system: evidence from two mouse models

D. Praticò, T. Ding, Yeumang Yao, 2005, Neurochemistry International.

Vitamin E: murine studies versus clinical trials.

D. Praticò, 2001, Italian heart journal : official journal of the Italian Federation of Cardiology.

Increased Oxidative Stress in Scavenger Receptor BI Knockout Mice With Dysfunctional HDL

D. Praticò, D. Stengel, T. V. van Berkel, 2007, Arteriosclerosis, thrombosis, and vascular biology.

Long-term intermittent hypoxia: reduced excitatory hypoglossal nerve output.

D. Praticò, S. Veasey, G. Zhan, 2004, American journal of respiratory and critical care medicine.

Brain 5‐lipoxygenase over‐expression worsens memory, synaptic integrity, and tau pathology in the P301S mice

D. Praticò, P. Giannopoulos, Alana N. Vagnozzi, 2017, Aging cell.

Increased plasma 8,12-iso-iPF2alpha- VI levels in relapsing multiple sclerosis patients are not predictive of disease progression

F. Barkhof, C. Polman, D. Praticò, 2012, Multiple sclerosis.

Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles

D. Praticò, Y. Joshi, A. D. Meco, 2014, Neurobiology of Aging.

Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment

J. Trojanowski, C. Clark, V. Lee, 2005, Annals of neurology.

Symposia Abstracts

Lisa Y. M. Chuah, P. K. Banerjee, J. Siegel, 2005 .

Enhanced brain levels of 8,12-iso-iPF2α-VI differentiate AD from frontotemporal dementia

J. Trojanowski, C. Clark, V. Lee, 2003, Neurology.

HEMOSTASIS , THROMBOSIS , AND VASCULAR BIOLOGY Ongoing Prothrombotic State in Patients With Antiphospholipid Antibodies : A Role for Increased Lipid Peroxidation

G. FitzGerald, D. Praticò, J. Rokach, 1999 .

Inflammaging: mechanisms and role in the cardiac and vasculature

G. Lip, M. Vinciguerra, D. Praticò, 2023, Trends in Endocrinology & Metabolism.

The 5-Lipoxygenase as a Common Pathway for Pathological Brain and Vascular Aging

D. Praticò, J. Chu, 2009, Cardiovascular psychiatry and neurology.

Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence

D. Praticò, M. Madesh, Jian-guo Li, 2015, Scientific Reports.

Involvement of 5-Lipoxygenase in the Corticosteroid-Dependent Amyloid Beta Formation: In Vitro and In Vivo Evidence

D. Praticò, S. Puccio, J. Chu, 2011, PloS one.

5‐lipoxygenase as an endogenous modulator of amyloid beta formation in vivo

D. Praticò, J. Chu, 2011, Annals of neurology.

Dysregulation of the Retromer Complex System in Down Syndrome

Daohai Yu, D. Praticò, M. Curtis, 2020, Annals of neurology.

Effects of myocardial ischemia/reperfusion injury on plasma metabolomic profile during aging

D. Promislow, D. Praticò, W. Koch, 2020, Aging cell.

Downregulation of autophagy by 12/15Lipoxygenase worsens the phenotype of an Alzheimer’s disease mouse model with plaques, tangles, and memory impairments

D. Praticò, Jian-guo Li, J. Chu, 2018, Molecular Psychiatry.

Effects of vitamin C and aspirin in ischemic stroke‐related lipid peroxidation: Results of the AVASAS (Aspirin Versus Ascorbic acid plus Aspirin in Stroke) Study

P. Mecocci, D. Praticò, S. Ricci, 2005, BioFactors.

Plasma F2A Isoprostane Levels in Alzheimer’s and Parkinson’s Disease

J. Growdon, B. Hyman, D. Praticò, 2007, Neurodegenerative Diseases.

Commentary on “Optimal design of clinical trials for drugs designed to slow the course of Alzheimer℉s disease.” Biochemical biomarkers of late-life dementia

J. Trojanowski, C. Clark, V. Lee, 2006, Alzheimer's & Dementia.

A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles

D. Praticò, Jian-guo Li, B. Blass, 2020, Molecular Neurodegeneration.

Neuroinflammation and Alzheimer’s disease: lessons learned from 5-lipoxygenase

D. Praticò, Y. Joshi, 2014 .

Cortical biochemistry in MCI and Alzheimer disease

S. Leurgans, J. Trojanowski, V. Lee, 2007, Neurology.

Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer’s disease mouse model

D. Praticò, J. Chu, 2012, Journal of Neuroinflammation.

Inflammatory hypotheses: novel mechanisms of Alzheimer’s neurodegeneration and new therapeutic targets?

John Q Trojanowski, J. Trojanowski, D. Praticò, 2000, Neurobiology of Aging.

Elevated cerebrospinal fluid levels of prostaglandin E2 and 15‐(S)‐hydroxyeicosatetraenoic acid in multiple sclerosis

K. Blennow, D. Praticò, H. Zetterberg, 2009, Journal of internal medicine.

Overexpression of 12/15-lipoxygenase increases anxiety behavior in female mice

D. Praticò, Y. Joshi, A. D. Meco, 2014, Neurobiology of Aging.

The Alzheimer’s disease GWAS risk alleles in the ABCA7 promoter and 5’ region reduce ABCA7 expression

Xinghua Shi, D. Praticò, N. Lyssenko, 2022, Acta Neuropathologica.

Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence

D. Praticò, Y. Joshi, 2014, Oxidative medicine and cellular longevity.

Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury

J. Trojanowski, V. Lee, D. Praticò, 2004 .

Lipid peroxidation and the aging process.

D. Praticò, 2002, Science of aging knowledge environment : SAGE KE.

The neurobiology of isoprostanes and Alzheimer's disease.

D. Praticò, 2010, Biochimica et biophysica acta.

12/15-LIPOXYGENASE INHIBITION REVERSES COGNITIVE IMPAIRMENT, AMYLOIDOSIS, TAU AND SYNAPTIC PATHOLOGY BY STIMULATING AUTOPHAGY IN THE BRAIN OF AGED 3XTG MICE

D. Praticò, Jian-guo Li, E. Lauretti, 2016, Alzheimer's & Dementia.

Knockout of 5-Lipoxygenase Results in Age-Dependent Anxiety-Like Behavior in Female Mice

D. Praticò, Y. Joshi, 2011, PloS one.

F2 Isoprostane Levels in Plasma and Urine do not Support Increased Lipid Peroxidation in Cognitively Impaired Parkinson Disease Patients

C. Clark, D. Mu, A. Siderowf, 2008, Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology.

Severe In vivo hyper-homocysteinemia is not associatedwith elevation of amyloid-beta peptides in the Tg2576 mice.

Jia-min Zhuo, D. Praticò, 2010, Journal of Alzheimer's disease : JAD.

Amelioration of the Alzheimer's Disease Phenotype by Absence of 12/15-Lipoxygenase

Jia-min Zhuo, D. Praticò, C. Chinnici, 2010, Biological Psychiatry.

Specificity of ABCA7-mediated cell lipid efflux.

D. Rader, D. Praticò, Xianlin Han, 2022, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Alzheimer’s disease: using gene/protein network machine learning for molecule discovery in olive oil

Guadalupe Gonzalez, I. Laponogov, K. Veselkov, 2023, Human Genomics.

Extra-virgin olive oil, cognition and brain health

D. Praticò, L. Iuliano, E. Lauretti, 2021 .

Regional and temporal miRNAs expression profile in a transgenic mouse model of tauopathy: implication for its pathogenesis

D. Praticò, E. Lauretti, Ozlem Dincer, 2020, Molecular Psychiatry.

Causes and Consequences of Oxidative Stress in Neurodegenerative Diseases

D. Praticò, 2005 .

Sex differences in susceptibility to oxidative injury and sleepiness from intermittent hypoxia.

D. Praticò, S. Veasey, G. Zhan, 2006, Sleep.

D. Praticò, 2011 .

Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice

D. Praticò, Y. Joshi, E. Lauretti, 2016, Molecular Psychiatry.

Portal levels of the isoprostane F2 alpha-III, a marker of lipid peroxidation, do not correlate with increased portal pressure in cirrhotic patients.

G. FitzGerald, D. Praticò, F. Violi, 1998, Journal of investigative medicine : the official publication of the American Federation for Clinical Research.

Cyclooxygenase dependent formation of 8-iso-prostaglandin F2 alpha by human platelets.

G. FitzGerald, D. Praticò, J. Lawson, 1995, Advances in prostaglandin, thromboxane, and leukotriene research.

Circadian rhythm dysfunction: a novel environmental risk factor for Parkinson’s disease

S. Merali, D. Praticò, E. Lauretti, 2017, Molecular Psychiatry.

Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of γ-secretase.

D. Praticò, J. Chu, 2011, The American journal of pathology.

Learning Impairments, Memory Deficits, and Neuropathology in Aged Tau Transgenic Mice Are Dependent on Leukotrienes Biosynthesis: Role of the cdk5 Kinase Pathway

D. Praticò, P. Giannopoulos, Jian Chiu, 2018, Molecular Neurobiology.

Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice

D. Praticò, P. Giannopoulos, Jian Chiu, 2018, Aging cell.

Increased oxidant stress in liver cirrhosis

D. Praticò, S. Basili, C. Cordova, 1996 .