S. Helisalmi

M. Laakso, S. Helisalmi, J. Tapanainen, 2005, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.

Metabolite Signature in the Carriers of Pathogenic Genetic Variants for Cardiomyopathy: A Population-Based METSIM Study

M. Laakso, S. Helisalmi, J. Vangipurapu, 2022, Metabolites.

Study on the Association between SOAT1 Polymorphisms, Alzheimer’s Disease Risk and the Level of CSF Biomarkers

H. Soininen, M. Hiltunen, S. Helisalmi, 2007, Dementia and Geriatric Cognitive Disorders.

CTLA-4 polymorphism 49A–G is associated with placental abruption and preeclampsia in Finnish women

S. Helisalmi, K. Punnonen, L. Keski-Nisula, 2008, Clinical chemistry and laboratory medicine.

No association between high temperature requirement 1 (HTRA1) gene polymorphisms and Alzheimer's disease

H. Soininen, M. Hiltunen, S. Helisalmi, 2011, Neurobiology of Aging.

NDUFA1 p.Gly32Arg variant in early-onset dementia

M. Hiltunen, S. Helisalmi, A. Remes, 2022, Neurobiology of Aging.

Apolipoprotein E polymorphism in patients with different neurodegenerative disorders

H. Soininen, A. Mannermaa, S. Helisalmi, 1996, Neuroscience Letters.

Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis

D. Rueckert, H. Soininen, R. Vanninen, 2018, Dementia and Geriatric Cognitive Disorders Extra.

Polymorphisms of interleukin-6, hepatic lipase and calpain-10 genes, and preeclampsia.

M. Laakso, M. Hiltunen, S. Helisalmi, 2006, European journal of obstetrics, gynecology, and reproductive biology.

Amyloid-β and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus.

H. Tanila, H. Soininen, M. Hiltunen, 2015, Journal of Alzheimer's disease : JAD.

Tumour necrosis factor-α gene haplotype is associated with pre-eclampsia

M. Laakso, M. Hiltunen, S. Helisalmi, 2005 .

Multimodal analysis to predict shunt surgery outcome of 284 patients with suspected idiopathic normal pressure hydrocephalus

Jyrki Lötjönen, Anna Sutela, Ville Leinonen, 2016, Acta Neurochirurgica.

Plasma Cell Membrane Glycoprotein-1 K121Q Polymorphism in Preeclampsia

M. Laakso, M. Hiltunen, S. Helisalmi, 2006, Gynecologic and Obstetric Investigation.

Lipid profile factors and apolipoprotein E polymorphism in Alzheimer’s disease

S. Helisalmi, 2007 .

Astrogliosis and the ApoE genotype. an immunohistochemical study of postmortem human brain tissue.

M. Laakso, H. Soininen, S. Helisalmi, 1999, Dementia and geriatric cognitive disorders.

Low Serum High-Density Lipoprotein Cholesterol Levels Associate with the C9orf72 Repeat Expansion in Frontotemporal Lobar Degeneration Patients

H. Soininen, A. Hall, P. Hartikainen, 2019, Journal of Alzheimer's disease : JAD.

Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease

H. Stefánsson, D. Rujescu, A. Ingason, 2015, Nature Genetics.

Flanking Markers of Cystatin C (CST3) Gene Do Not Show Association with Alzheimer’s Disease

H. Soininen, M. Hiltunen, S. Helisalmi, 2009, Dementia and Geriatric Cognitive Disorders.

Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are associated with polycystic ovary syndrome.

M. Hiltunen, S. Helisalmi, E. Romppanen, 2003, Fertility and sterility.

An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population

H. Soininen, M. Hiltunen, S. Helisalmi, 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

ADAMTS9 locus associates with increased risk of wet AMD

I. Immonen, M. Uusitupa, M. Hiltunen, 2014, Acta ophthalmologica.

Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Nick C Fox, Michelle K. Lupton, Charles C. White, 2019, Nature Genetics.

Prevalence of C9ORF72 Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus

H. Soininen, R. Vanninen, M. Hiltunen, 2019, Dementia and Geriatric Cognitive Disorders.

Cerebrospinal Fluid TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Patients with and without the C9ORF72 Hexanucleotide Expansion

P. Hartikainen, S. Helisalmi, S. Herukka, 2016, Dementia and Geriatric Cognitive Disorders Extra.

The role of the FTD-ALS associated C9orf72 expansion in suicide victims

M. Hiltunen, S. Helisalmi, A. Remes, 2016, Amyotrophic lateral sclerosis & frontotemporal degeneration.

The C9ORF72 expansion sizes in patients with psychosis: a population-based study on the Northern Finland Birth Cohort 1966

M. Hiltunen, S. Helisalmi, J. Miettunen, 2016, Psychiatric genetics.

The Association Between Frontotemporal Lobar Degeneration and Bullous Pemphigoid.

P. Hartikainen, S. Helisalmi, A. Koivisto, 2018, Journal of Alzheimer's disease : JAD.

Molecular Epidemiology of Charcot-Marie-Tooth Disease in Northern Ostrobothnia, Finland: A Population-Based Study

M. Hiltunen, S. Helisalmi, K. Majamaa, 2017, Neuroepidemiology.

Screening for amyloid beta precursor protein codon 665, 670 671 and 717 mutations in Finnish patients with Alzheimer's disease

H. Soininen, A. Mannermaa, S. Helisalmi, 1996, Neuroscience Letters.

Serum total TDP-43 levels are decreased in frontotemporal dementia patients with C9orf72 repeat expansion or concomitant motoneuron disease phenotype

P. Hartikainen, S. Helisalmi, V. Leinonen, 2022, Alzheimer's Research & Therapy.

Polymorphism of the interleukin 1 receptor antagonist (IL1Ra) gene and placental abruption.

S. Helisalmi, K. Punnonen, L. Keski-Nisula, 2008, Journal of reproductive immunology.

Polymorphism in the interleukin 1 receptor antagonist gene in women with preeclampsia.

J. Salonen, M. Hiltunen, S. Helisalmi, 2003, Journal of reproductive immunology.

Endothelial Nitric Oxide Synthase Polymorphism in Preeclampsia

M. Hiltunen, S. Helisalmi, E. Romppanen, 2003, The Journal of the Society for Gynecologic Investigation: JSGI.

Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia

A. Mannermaa, M. Hiltunen, S. Helisalmi, 2002, European Journal of Human Genetics.

M385T polymorphism in the factor V gene, but not Leiden mutation, is associated with placental abruption in Finnish women.

S. Helisalmi, E. Romppanen, K. Punnonen, 2004, Placenta.

Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation

J. Salonen, M. Hiltunen, S. Helisalmi, 2004, European Journal of Human Genetics.

Endothelial Nitric Oxide Synthase Polymorphism in Preeclampsia

M. Hiltunen, S. Helisalmi, E. Romppanen, 2003, Journal of the Society for Gynecologic Investigation.

Alzheimer pathology of patients carrying apolipoprotein E epsilon 4 allele.

H. Soininen, A. Mannermaa, S. Helisalmi, 1995, Neurobiology of aging.

The 121Q allele of the plasma cell membrane glycoprotein 1 gene predisposes to polycystic ovary syndrome.

M. Laakso, S. Helisalmi, J. Tapanainen, 2004, Fertility and sterility.

Endothelial nitric oxide synthase polymorphism is not associated with placental abruption in Finnish women.

S. Helisalmi, E. Romppanen, K. Punnonen, 2005, Fetal diagnosis and therapy.

Subtle Cognitive Impairment and Alzheimer's Disease-Type Pathological Changes in Cerebrospinal Fluid are Common Among Neurologically Healthy Subjects.

H. Soininen, M. Hallikainen, T. Paajanen, 2018, Journal of Alzheimer's disease : JAD.

The Expression of Transthyretin and Amyloid-β Protein Precursor is Altered in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients.

H. Soininen, M. Hiltunen, S. Helisalmi, 2015, Journal of Alzheimer's disease : JAD.

Brain β-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline

H. Soininen, M. Kivipelto, Y. Liu, 2018, American Journal of Neuroradiology.

Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers

W. M. van der Flier, D. Rujescu, I. Giegling, 2022, Acta Neuropathologica.

CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings

H. Soininen, J. Rinne, M. Hiltunen, 2012, Neurology.

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Nick C Fox, Catherine A. Macleod, W. M. van der Flier, 2022, Nature Genetics.

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

W. M. van der Flier, M. Fornage, D. Rujescu, 2021, Nature Communications.

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Nick C Fox, Michelle K. Lupton, Charles C. White, 2019, Nature Genetics.

Adiponectin gene haplotype is associated with preeclampsia.

M. Laakso, M. Hiltunen, S. Helisalmi, 2006, Genetic testing.

Genetic analysis of BDNF and TrkB gene polymorphisms in Alzheimer’s disease

Arto Mannermaa, Tuomo Hänninen, Hilkka Soininen, 2005, Journal of Neurology.

Low-Activity Haplotype of the Microsomal Epoxide Hydrolase Gene Is Protective Against Placental Abruption

M. Hiltunen, S. Helisalmi, E. Romppanen, 2004, The Journal of the Society for Gynecologic Investigation: JSGI.

Association of single nucleotide polymorphisms of the bile salt export pump gene with intrahepatic cholestasis of pregnancy.

M. Hiltunen, S. Helisalmi, K. Punnonen, 2003, Scandinavian journal of gastroenterology.

Genome-wide linkage disequilibrium mapping of late-onset Alzheimer’s disease in Finland

D. Easton, H. Soininen, A. Mannermaa, 2001, Neurology.

Genome-wide linkage disequilibrium mapping of late onset Alzheimer's disease in Finland

H. Soininen, A. Mannermaa, M. Hiltunen, 2000, Neurobiology of Aging.

Astrogliosis and the ApoE Genotype

M. Laakso, H. Soininen, S. Helisalmi, 1999, Dementia and Geriatric Cognitive Disorders.

High Risk Population Isolate Reveals Low Frequency Variants Predisposing to Intracranial Aneurysms

T. Lehtimäki, L. Kiemeney, V. Salomaa, 2014, PLoS genetics.

Caspase-8, association with Alzheimer’s Disease and functional analysis of rare variants

J. Haines, M. Pericak-Vance, G. Schellenberg, 2017, PloS one.

Genetics of Alzheimer’s disease

H. Soininen, M. Kivipelto, M. Hiltunen, 2012 .

Polymorphisms in the CYP19 gene confer increased risk for Alzheimer disease

E. Corder, H. Soininen, A. Mannermaa, 2004, Neurology.

Seladin-1 transcription is linked to neuronal degeneration in Alzheimer’s disease

H. Soininen, A. Salminen, A. Mannermaa, 2002, Neuroscience.

Identification of a novel 4.6-kb genomic deletion in presenilin-1 gene which results in exclusion of exon 9 in a Finnish early onset Alzheimer's disease family: an Alu core sequence-stimulated recombination?

H. Soininen, A. Mannermaa, M. Hiltunen, 2000, European Journal of Human Genetics.

Linkage disequilibrium in the 13q12 region in Finnish late onset Alzheimer's disease patients

H. Soininen, A. Mannermaa, M. Hiltunen, 1999, European Journal of Human Genetics.

MOLECULAR GENETICS OF ALZHEIMER'S DISEASE With special emphasis on presenilin, amyloid beta precursor protein and apolipoprotein E genes

S. Helisalmi, Kuopion Yliopisto, 1998 .

Genetic study between SIRT1, PPARD, PGC-1α genes and Alzheimer’s disease

M. Laakso, H. Soininen, A. Salminen, 2008, Journal of Neurology.

Frequent gene dosage alterations in stromal cells of epithelial ovarian carcinomas

A. Mannermaa, V. Kosma, V. Kataja, 2006, International journal of cancer.

The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study.

P. Bosco, J. Haines, M. Pericak-Vance, 2010, Journal of Alzheimer's disease : JAD.

New insights on the genetic etiology of Alzheimer’s and related dementia

Nick C Fox, Catherine A. Macleod, W. M. van der Flier, 2020 .

MPO and APOEepsilon4 polymorphisms interact to increase risk for AD in Finnish males.

H. Soininen, A. Mannermaa, M. Hiltunen, 2000, Neurology.

Molecular epidemiology of hereditary ataxia in Finland

M. Laakso, S. Helisalmi, K. Majamaa, 2021, BMC Neurology.

Gamma 2 Actin Gene (Enteric Type) Polymorphism Is Not Associated with Obstetric Cholestasis or Preeclampsia

M. Hiltunen, S. Helisalmi, S. Heinonen, 2007, Fetal Diagnosis and Therapy.

Plasminogen activator inhibitor-1 polymorphism in women with pre-eclampsia.

M. Hiltunen, S. Helisalmi, E. Romppanen, 2003, Genetic testing.

Maternal susceptibility locus for obstetric cholestasis maps to chromosome region 2p13 in Finnish patients.

A. Mannermaa, M. Hiltunen, S. Helisalmi, 2001, Scandinavian journal of gastroenterology.

Relation of coronary atherosclerosis and apolipoprotein E genotypes in Alzheimer patients.

H. Soininen, A. Mannermaa, S. Helisalmi, 1995, Stroke.

24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial

K. Blennow, P. Scheltens, F. Barkhof, 2017, The Lancet Neurology.

Interleukin 1 Alpha Gene Polymorphism as a Susceptibility Factor in Alzheimer’s Disease and Its Influence on the Extent of Histopathological Hallmark Lesions of Alzheimer’s Disease

M. Laakso, H. Soininen, A. Mannermaa, 2002, Dementia and Geriatric Cognitive Disorders.

DNA fragmentation, gliosis and histological hallmarks of Alzheimer’s disease

H. Soininen, S. Helisalmi, I. Alafuzoff, 2000, Acta Neuropathologica.

A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein ε4 allele

Arto Mannermaa, Hilkka Soininen, H. Soininen, 1995, Neuroscience Letters.

Genetic Loci Associated with Alzheimer’s Disease and Cerebrospinal Fluid Biomarkers in a Finnish Case-Control Cohort

T. Lehtimäki, H. Soininen, P. Visser, 2013, PloS one.

Longitudinal SPECT study in Alzheimer’s disease: relation to apolipoprotein E polymorphism

H. Soininen, A. Mannermaa, P. Hartikainen, 1998, Journal of neurology, neurosurgery, and psychiatry.

SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E epsilon 4 allele.

H. Soininen, M. Laakso, A. Mannermaa, 1996, Journal of neurology, neurosurgery, and psychiatry.

Alzheimer pathology of patients carrying apoliprotein E ϵ4 allele

H. Soininen, A. Mannermaa, S. Helisalmi, 1995, Neurobiology of Aging.

Apolipoprotein E polymorphism and Alzheimer's disease in Eastern Finland

H. Soininen, A. Mannermaa, S. Helisalmi, 1995, Neuroscience Letters.

SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E £4 allele

H. Soininen, M. Laakso, A. Mannermaa, 2022 .

Metabolic Profiles Help Discriminate Mild Cognitive Impairment from Dementia Stage in Alzheimer’s Disease

H. Soininen, M. Hallikainen, M. van Gils, 2020, Journal of Alzheimer's disease : JAD.

Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations

Hilkka Soininen, Sandro Sorbi, Philippe Amouyel, 2011, Neurobiology of Aging.

Increased expression of Aβ degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology

H. Tanila, H. Soininen, M. Hiltunen, 2008, Neuroscience Letters.

Low prevalence of APP duplications in Swedish and Finnish patients with early-onset Alzheimer's disease

H. Soininen, M. Hiltunen, S. Helisalmi, 2008, European Journal of Human Genetics.

GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients.

H. Soininen, M. Kivipelto, M. Hiltunen, 2012, Journal of Alzheimer's disease : JAD.

Genetic study evaluating LDLR polymorphisms and Alzheimer's disease

H. Soininen, M. Hiltunen, S. Helisalmi, 2008, Neurobiology of Aging.

Familial idiopathic normal pressure hydrocephalus

M. Perola, M. Hiltunen, S. Helisalmi, 2015, Journal of the Neurological Sciences.

Neuropsychological Profile in the C9ORF72 Associated Behavioral Variant Frontotemporal Dementia.

T. Hänninen, P. Hartikainen, M. Hiltunen, 2017, Journal of Alzheimer's disease : JAD.

Heparan sulfate proteoglycan 2 polymorphism in Alzheimer's disease and correlation with neuropathology

H. Soininen, A. Mannermaa, M. Hiltunen, 2003, Neuroscience Letters.

Lower Counts of Astroglia and Activated Microglia in Patients with Alzheimer's Disease with Regular Use of Non-Steroidal Anti-Inflammatory Drugs.

H. Soininen, S. Helisalmi, I. Alafuzoff, 2000, Journal of Alzheimer's disease : JAD.

Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue

M. Laakso, H. Soininen, S. Helisalmi, 1999, Acta Neuropathologica.

APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus

H. Soininen, M. Hiltunen, S. Helisalmi, 2012, Journal of Neurology, Neurosurgery & Psychiatry.

Longitudinal changes of CSF biomarkers in Alzheimer's disease.

Hilkka Soininen, H. Soininen, P. Hartikainen, 2011, Journal of Alzheimer's disease : JAD.

The level of cerebrospinal fluid tau correlates with neurofibrillary tangles in Alzheimer's disease

H. Soininen, S. Helisalmi, I. Alafuzoff, 1997, Neuroreport.

CSF Abeta42, Tau and phosphorylated Tau, APOE epsilon4 allele and MCI type in progressive MCI.

Hilkka Soininen, Susanna Tervo, Merja Hallikainen, 2007, Neurobiology of aging.

GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance

P. Hartikainen, S. Helisalmi, A. Koivisto, 2021, Journal of Neurology, Neurosurgery, and Psychiatry.

MPO and APOEε4 polymorphisms interact to increase risk for AD in Finnish males

A. Mannermaa, S. Helisalmi, I. Alafuzoff, 2000, Neurology.

Estrogen receptor beta gene variants are associated with increased risk of Alzheimer's disease in women

Arto Mannermaa, Tuomo Hänninen, Hilkka Soininen, 2005, European Journal of Human Genetics.

Rare Variants in Calcium Homeostasis Modulator 1 (CALHM1) Found in Early Onset Alzheimer’s Disease Patients Alter Calcium Homeostasis

J. Molinuevo, H. Soininen, F. Rubio-Moscardo, 2013, PloS one.

CALHM1 P86L polymorphism does not alter amyloid-β or tau in cerebrospinal fluid

H. Soininen, R. Tanzi, M. Hiltunen, 2010, Neuroscience Letters.

β‐Amyloid deposition in brains of subjects with diabetes

H. Soininen, A. Mannermaa, S. Helisalmi, 2009, Neuropathology and applied neurobiology.

Promoter polymorphism (–491A/T) in the APOE gene of Finnish Alzheimer’s disease patients and control individuals

H. Soininen, A. Mannermaa, M. Hiltunen, 1999, Journal of Neurology.

Combined risk effects of IDE and NEP gene variants on Alzheimer disease

H. Soininen, A. Mannermaa, M. Hiltunen, 2009, Journal of Neurology, Neurosurgery & Psychiatry.

Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease.

H. Soininen, M. Hiltunen, S. Helisalmi, 2012, Journal of Alzheimer's disease : JAD.

Insulin-degrading enzyme is genetically associated with Alzheimer’s disease in the Finnish population

H. Soininen, R. Tanzi, A. Mannermaa, 2007, Journal of Medical Genetics.

Polymorphisms in neprilysin gene affect the risk of Alzheimer’s disease in Finnish patients

H. Soininen, A. Mannermaa, M. Hiltunen, 2004, Journal of Neurology, Neurosurgery & Psychiatry.

A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 allele.

H. Soininen, A. Mannermaa, S. Helisalmi, 1995, Neuroscience letters.

Butyrylcholinesterase K variant and apolipoprotein E4 genes do not act in synergy in Finnish late-onset Alzheimer's disease patients

H. Soininen, A. Mannermaa, M. Hiltunen, 1998, Neuroscience Letters.

Tumour necrosis factor-alpha gene haplotype is associated with pre-eclampsia.

M. Laakso, M. Hiltunen, S. Helisalmi, 2005, Molecular human reproduction.

Detecting Amyloid Positivity in Elderly With Increased Risk of Cognitive Decline

H. Soininen, M. Kivipelto, M. van Gils, 2020, Frontiers in Aging Neuroscience.

Effects of Alzheimer's disease-associated risk loci on cerebrospinal fluid biomarkers and disease progression: a polygenic risk score approach.

T. Lehtimäki, H. Soininen, A. Hall, 2014, Journal of Alzheimer's disease : JAD.

Melatonin receptor type 1A gene linked to Alzheimer’s disease in old age

T. Paunio, D. Stone, T. Peuralinna, 2018, Sleep.

Major decrease in the volume of the entorhinal cortex in patients with Alzheimer’s disease carrying the apolipoprotein E ε4 allele

H. Soininen, S. Helisalmi, P. Riekkinen, 1998, Journal of neurology, neurosurgery, and psychiatry.

Metabolome in progression to Alzheimer's disease

H. Soininen, V. Julkunen, M. Hallikainen, 2011, Translational Psychiatry.

Effects of estradiol on spatial learning, hippocampal cytochrome P450 19, and estrogen alpha and beta mRNA levels in ovariectomized female mice

H. Tanila, H. Soininen, S. Helisalmi, 2006, Neuroscience.

Novel Rare SORL1 Variants in Early-Onset Dementia.

M. Hiltunen, S. Helisalmi, K. Pylkäs, 2021, Journal of Alzheimer's disease : JAD.

Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Patients with Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis with the C9ORF72 Repeat Expansion

P. Hartikainen, S. Helisalmi, S. Herukka, 2015, Dementia and Geriatric Cognitive Disorders.

Copy number loss in SFMBT1 is common among Finnish and Norwegian patients with iNPH

H. Soininen, M. Hiltunen, S. Helisalmi, 2018, Neurology: Genetics.

Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial

H. Soininen, M. Kivipelto, J. Tuomilehto, 2018, JAMA neurology.

Genetic Variation in δ-Opioid Receptor Associates with Increased β- and γ-Secretase Activity in the Late Stages of Alzheimer's Disease.

H. Soininen, M. Hiltunen, S. Helisalmi, 2015, Journal of Alzheimer's disease : JAD.

Prevalence of immunological diseases in a Finnish frontotemporal lobar degeneration cohort with the C9orf72 repeat expansion carriers and non-carriers

P. Hartikainen, S. Helisalmi, A. Koivisto, 2018, Journal of Neuroimmunology.

MTHFR C677T Polymorphism is Not Associated with Placental Abruption or Preeclampsia in Finnish Women

S. Helisalmi, E. Romppanen, K. Punnonen, 2006, Hypertension in pregnancy.

Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models

Juha E. Jääskeläinen, Ville Leinonen, Hilkka Soininen, 2015, Neurobiology of Aging.

Effects of NR1H3 Genetic Variation on the Expression of Liver X Receptor α and the Progression of Alzheimer's Disease

H. Soininen, M. Hiltunen, S. Helisalmi, 2013, PloS one.

Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease.

H. Soininen, R. Tanzi, M. Hiltunen, 2013, Journal of Alzheimer's disease : JAD.

Mutation Analysis of the Genes Associated with Parkinson's Disease in a Finnish Cohort of Early-Onset Dementia.

M. Hiltunen, S. Helisalmi, A. Remes, 2020, Journal of Alzheimer's disease : JAD.

H. Soininen, S. Helisalmi, P. Riekkinen, 1998, Neurology.

Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E ϵ4 allele

H. Soininen, K. Partanen, A. Mannermaa, 1995, Neurology.

The load and distribution of β‐amyloid in brain tissue of patients with Alzheimer's disease

H. Soininen, S. Helisalmi, I. Alafuzoff, 2001, Acta neurologica Scandinavica.

Cysteine 27 Variant of the δ-Opioid Receptor Affects Amyloid Precursor Protein Processing through Altered Endocytic Trafficking

H. Soininen, R. Tanzi, M. Hiltunen, 2011, Molecular and Cellular Biology.

Associations of CAIDE Dementia Risk Score with MRI, PIB-PET measures, and cognition

H. Soininen, M. Kivipelto, R. Vanninen, 2017, Journal of Alzheimer's disease : JAD.

Mutation Analysis of the Genes Linked to Early Onset Alzheimer's Disease and Frontotemporal Lobar Degeneration.

M. Hiltunen, S. Helisalmi, A. Remes, 2019, Journal of Alzheimer's disease : JAD.

Protein Processing through Altered Endocytic Trafficking

H. Soininen, R. Tanzi, M. Hiltunen, 2011 .

Predicting Development of Alzheimer's Disease in Patients with Shunted Idiopathic Normal Pressure Hydrocephalus.

H. Soininen, M. Kivipelto, A. Hall, 2019, Journal of Alzheimer's disease : JAD.

Diabetes is associated with familial idiopathic normal pressure hydrocephalus: a case–control comparison with family members

M. Perola, H. Soininen, M. Hiltunen, 2020, Fluids and barriers of the CNS.

Effects of Alzheimer's Disease-Associated Risk Loci on Amyloid-β Accumulation in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients.

H. Soininen, M. Hiltunen, S. Helisalmi, 2016, Journal of Alzheimer's disease : JAD.

Somatostatin genetic variants modify the risk for Alzheimer's disease among Finnish patients

H. Soininen, M. Hiltunen, S. Helisalmi, 2007, Journal of Neurology.

CSF biomarkers for Alzheimer's pathology and the effect size of APOE ɛ4

K. Blennow, J. Hardy, J. Schott, 2013, Molecular Psychiatry.

No association between α 1-antichymotrypsin polymorphism, apolipoprotein E and patients with late-onset Alzheimer's disease

H. Soininen, A. Mannermaa, S. Helisalmi, 1997, Neuroscience Letters.

The ability of THA treatment to increase cortical alpha waves is related to apolipoprotein E genotype of Alzheimer disease patients

H. Soininen, S. Helisalmi, J. Partanen, 1997, Psychopharmacology.

Alzheimer's Disease-Related Polymorphisms in Shunt-Responsive Idiopathic Normal Pressure Hydrocephalus.

H. Soininen, R. Vanninen, M. Hiltunen, 2017, Journal of Alzheimer's disease : JAD.

Correction: Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

M. Fornage, K. Lunetta, S. Gabriel, 2019, Molecular Psychiatry.

Genetic variation in apolipoprotein D and Alzheimer’s disease

E. Corder, H. Soininen, A. Mannermaa, 2004, Journal of Neurology.

Selegiline treatment and the extent of degenerative changes in brain tissue of patients with Alzheimer's disease

H. Soininen, M. Hallikainen, S. Helisalmi, 2000, European Journal of Clinical Pharmacology.

Late-onset and classic phenotypes of Fabry disease in males with the GLA-Thr410Ala mutation

S. Helisalmi, J. Kuusisto, M. Hedman, 2023, Open Heart.

Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population

H. Soininen, A. Mannermaa, M. Hiltunen, 2004, Neurology.

Melatonin receptor type 1A gene linked to Alzheimer’s disease in old age

Traynor, T. Paunio, D. Stone, 2018, Sleep.

An association between a subset of Finnish late-onsetAlzheimer’s disease and alpha2-macroglobulin

M. Laakso, H. Soininen, A. Mannermaa, 2001, Neurogenetics.

Severity of Cardiovascular Disease, Apolipoprotein E Genotype, and Brain Pathology in Aging and Dementia

H. Soininen, A. Mannermaa, S. Helisalmi, 2000, Annals of the New York Academy of Sciences.

Longitudinal changes in CSF biomarkers

H. Soininen, P. Hartikainen, S. Helisalmi, 2011, Alzheimer's & Dementia.

Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer's disease

H. Soininen, M. Hiltunen, S. Helisalmi, 2008, Neuroscience Letters.

The association study between DHCR24 polymorphisms and Alzheimer's disease

H. Soininen, M. Hiltunen, S. Helisalmi, 2007, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

An association study of 21 potential Alzheimer's disease risk genes in a Finnish population.

H. Soininen, M. Hiltunen, S. Helisalmi, 2010, Journal of Alzheimer's disease : JAD.

Increased acetylcholinesterase activity in the CSF of Alzheimer patients carrying apolipoprotein epsilon4 allele.

H. Soininen, S. Helisalmi, P. Riekkinen, 1995, Neuroreport.

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Genetic, Nick C Fox, Michelle K. Lupton, 2019, Nature Genetics.

The Effect of TOMM40 Poly-T Repeat Lengths on Age of Onset and Cerebrospinal Fluid Biomarkers in Finnish Alzheimer's Disease Patients

H. Soininen, A. Hall, M. Hiltunen, 2014, Neurodegenerative Diseases.

CSF biomarkers for Alzheimer's pathology and the effect size of APOE ɛ4

K. Merikangas, K. Blennow, H. Qin, 2013, Molecular Psychiatry.

Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer's disease

H. Soininen, M. Hiltunen, S. Helisalmi, 2008, Neuroscience Letters.