H. Raslova

发表

Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation.

D. Bluteau, A. Balduini, N. Balayn, 2014, The Journal of clinical investigation.

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

Stefan N. Constantinescu, William Vainchenker, S. Constantinescu, 2005, Nature.

The Bystander Effect Mediated by the New Murine Gammaherpesvirus 72 — Thymidine Kinase/5′-Fluoro-2′-Deoxyuridine (MHV72-TK/5-FUdR) System in Vitro

H. Raslova, K. Mačáková, M. Kúdelová, 2000, Antiviral chemistry & chemotherapy.

Germline RUNX1 Intragenic Deletion: Implications for Accurate Diagnosis of FPD/AML

A. Baruchel, R. Favier, H. Raslova, 2019, HemaSphere.

Role of Rho-GTPases in megakaryopoiesis

W. Vainchenker, N. Debili, H. Raslova, 2021, Small GTPases.

The EHA Research Roadmap: Platelet Disorders

H. Raslova, M. Makris, Y. Gruel, 2021, HemaSphere.

Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect

W. Vainchenker, N. Debili, H. Raslova, 2017, Nature Communications.

A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene.

M. Bryckaert, W. Vainchenker, N. Debili, 2014, Blood.

Regulation of megakaryocyte maturation and platelet formation

D. Bluteau, W. Vainchenker, N. Debili, 2009, Journal of thrombosis and haemostasis : JTH.

Progress in understanding the diagnosis and molecular genetics of macrothrombocytopenias

R. Favier, H. Raslova, 2015, British journal of haematology.

Different impact of calreticulin mutations on human hematopoiesis in myeloproliferative neoplasms

F. Pasquier, E. Solary, W. Vainchenker, 2020, Oncogene.

Monocyte/Macrophage Dysfunctions Do Not Impair the Promotion of Myelofibrosis by High Levels of Thrombopoietin1

W. Vainchenker, H. Raslova, M. Tulliez, 2006, The Journal of Immunology.

A unique clonal JAK 2 mutation leading to constitutive signalling causes polycythaemia

S. Constantinescu, H. Raslova, R. Berger, 2005 .

An inherited gain‐of‐function risk allele in EPOR predisposes to familial JAK2V617F myeloproliferative neoplasms

W. Vainchenker, H. Raslova, E. Deconinck, 2022, British journal of haematology.

An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L.

C. Pecquet, G. Leverger, W. Vainchenker, 2016, Blood.

amplification Megakaryocyte polyploidization is associated with a functional gene

G. Kroemer, W. Vainchenker, N. Debili, 2013 .

differentiation megakaryocyte progenitors and late stages of megakaryocyte Mammalian target of rapamycin (mTOR) regulates both proliferation of

W. Vainchenker, N. Debili, H. Raslova, 2012 .

Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation.

W. Vainchenker, N. Debili, H. Raslova, 2006, Blood.

The serum response factor (SRF)/megakaryocytic acute leukemia (MAL) network participates in megakaryocyte development

W. Vainchenker, N. Debili, H. Raslova, 2010, Leukemia.

University of Birmingham Critical role of the HDAC6-cortactin axis in human-megakaryocytes maturation leading to a proplatelet-formation defect

W. Vainchenker, N. Debili, H. Raslova, 2017 .

The cell division control protein 42–Src family kinase–neural Wiskott–Aldrich syndrome protein pathway regulates human proplatelet formation

W. Vainchenker, N. Debili, H. Raslova, 2016, Journal of thrombosis and haemostasis : JTH.

CALR mutant protein rescues the response of MPL p.R464G variant associated with CAMT to eltrombopag.

N. Balayn, W. Vainchenker, R. Favier, 2021, Blood.

Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model

W. Vainchenker, N. Debili, H. Raslova, 2022, The Journal of clinical investigation.

Developmental changes in human megakaryopoiesis

E. Solary, W. Vainchenker, N. Debili, 2013, Journal of thrombosis and haemostasis : JTH.

This information is current as High Levels of Thrombopoietin Impair the Promotion of Myelofibrosis by Monocyte / Macrophage Dysfunctions Do Not

W. Vainchenker, H. Raslova, M. Tulliez, 2006 .

ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.

C. Lefebvre, G. Leverger, W. Vainchenker, 2017, Cancer cell.

Megakaryocyte polyploidization: role in platelet production

W. Vainchenker, H. Raslova, 2020, Platelets.

Megakaryocyte and polyploidization.

W. Vainchenker, N. Debili, H. Raslova, 2018, Experimental hematology.

Susceptibility of mouse mammary glands to murine gammaherpesvirus 72 (MHV-72) infection: evidence of MHV-72 transmission via breast milk.

H. Raslova, J. Rajčáni, A. Sarasin, 2001, Microbial pathogenesis.

The Pediatric Acute Leukemia Fusion Oncogene ETO2-GLIS2 Increases Self-Renewal and Alters Differentiation in a Human Induced Pluripotent Stem Cells-Derived Model

W. Vainchenker, H. Raslova, A. Pession, 2019, HemaSphere.

Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis.

C. Pecquet, W. Vainchenker, H. Raslova, 2016, Blood.

Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants.

C. Pecquet, P. Courtoy, W. Vainchenker, 2016, Blood.

Inferring the dynamic of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms.

M. Hochberg, F. Pasquier, E. Solary, 2021, Blood.

Induced Pluripotent Stem Cells Enable Disease Modeling and Drug Screening in Calreticulin del52 and ins5 Myeloproliferative Neoplasms

W. Vainchenker, H. Raslova, M. Bonamino, 2021, HemaSphere.

Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN

W. Vainchenker, H. Raslova, J. Villeval, 2020, Nature Communications.

TET2 haploinsufficiency alters reprogramming into induced pluripotent stem cells.

S. Ogawa, W. Vainchenker, H. Raslova, 2020, Stem cell research.

Rare type 1-like and type 2-like calreticulin mutants induce similar myeloproliferative neoplasms as prevalent type 1 and 2 mutants in mice

W. Vainchenker, H. Raslova, J. Villeval, 2018, Oncogene.

Supplementary Figure S1

E. Solary, W. Vainchenker, N. Debili, 2012 .

New insights into regulation of αIIbβ3 integrin signaling by filamin A

M. Bryckaert, H. Raslova, F. Adam, 2021, Research and practice in thrombosis and haemostasis.

The RUNX1 database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy

Anna L. Brown, S. Fröhling, G. Natsoulis, 2021, Haematologica.

First description of revertant mosaicism in familial platelet disorder with predisposition to acute myelogenous leukaemia: correlation with the clinical phenotype.

H. Raslova, C. Marzac, N. Auger, 2020, Haematologica.

Mechanisms underlying platelet function defect in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia: potential role for candidate RUNX1 targets

D. Bluteau, H. Raslova, R. Laguens, 2014, Journal of thrombosis and haemostasis : JTH.

Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia.

D. Bluteau, W. Vainchenker, N. Debili, 2011, Blood.

Activity of nonmuscle myosin II isoforms determines localization at the cleavage furrow of megakaryocytes.

W. Vainchenker, N. Debili, H. Raslova, 2016, Blood.

Primary hematopoietic cells from DBA patients with mutations in RPL11 and RPS19 genes exhibit distinct erythroid phenotype in vitro

W. Vainchenker, H. Raslova, J. Larghero, 2012, Cell Death and Disease.

Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms

E. Solary, W. Vainchenker, N. Debili, 2013, Cell Death and Disease.

p210BCR-ABL reprograms transformed and normal human megakaryocytic progenitor cells into erythroid cells and suppresses FLI-1 transcription

W. Vainchenker, H. Raslova, V. Lazar, 2007, Leukemia.

Concomitant germ‐line RUNX1 and acquired ASXL1 mutations in a T‐cell acute lymphoblastic leukemia

D. Birnbaum, W. Vainchenker, R. Favier, 2013, European journal of haematology.

Disrupted filamin A/αIIbβ3 interaction induces macrothrombocytopenia by increasing RhoA activity.

M. Bryckaert, N. Balayn, W. Vainchenker, 2019, Blood.

Somatic mutations associated with leukemic progression of familial platelet disorder with predisposition to acute myeloid leukemia

O. Abdel-Wahab, R. Favier, H. Raslova, 2016, Leukemia.

Immunophenotypic study of atypical lymphocytes. Generated in peripheral blood and spleen of nude mice After MHV-72 infection.

H. Raslova, A. Sarasin, D. Blangy, 2000, Viral immunology.

Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint

W. Vainchenker, N. Debili, H. Raslova, 2016, Haematologica.

Acquired TET2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development of pre‐leukaemic clone resulting in T2‐ALL and AML‐M0

W. Vainchenker, R. Favier, H. Raslova, 2016, Journal of cellular and molecular medicine.

Acquired TET 2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development of pre-leukaemic clone resulting in T 2-ALL and AML-M 0

W. Vainchenker, H. Raslova, E. Macintyre, 2017 .

Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies

F. Pasquier, E. Solary, W. Vainchenker, 2015, Nature Genetics.

Germline variants in ETV 6 underlie reduced platelet formation , platelet dysfunction and increased levels of circulating CD 34 + progenitors

Kathleen, Franck, P. Morange, 2018 .

A new heterozygous mutation in GP1BA gene responsible for macrothrombocytopenia

H. Raslova, M. Alessi, X. Pillois, 2018, British journal of haematology.

A murine gammaherpesvirus.

H. Raslova, M. Kúdelová, J. Mistríková, 2000, Acta virologica.

Induced pluripotent stem cells and hematological malignancies: A powerful tool for disease modeling and drug development.

H. Raslova, I. Plo, B. Arkoun, 2020, Stem cell research.

Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach.

G. Kroemer, W. Vainchenker, N. Debili, 2007, Blood.

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera.

Stefan N Constantinescu, William Vainchenker, S. Constantinescu, 2005, Nature.

The abnormal proplatelet formation in MYH9‐related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition

P. Nurden, W. Vainchenker, N. Debili, 2013, Journal of thrombosis and haemostasis : JTH.

Dysmegakaryopoiesis of FPD/AML pedigrees with constitutional RUNX1 mutations is linked to myosin II deregulated expression.

D. Bluteau, N. Balayn, P. Nurden, 2012, Blood.

Megakaryocyte polyploidization is associated with a functional gene amplification.

Guido Kroemer, William Vainchenker, G. Kroemer, 2003, Blood.

Induced pluripotent stem cells : from history to applications

W. Vainchenker, H. Raslova, F. Norol, 2013 .

MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9.

D. Bluteau, W. Vainchenker, N. Debili, 2009, Blood.

FLI1 monoallelic expression combined with its hemizygous loss underlies Paris-Trousseau/Jacobsen thrombopenia.

W. Vainchenker, N. Debili, R. Favier, 2004, The Journal of clinical investigation.

Eltrombopag, a potent stimulator of megakaryopoiesis

W. Vainchenker, H. Raslova, I. Plo, 2016, Haematologica.

Miniaturized 3D bone marrow tissue model to assess response to Thrombopoietin-receptor agonists in patients

D. Kaplan, A. Balduini, H. Raslova, 2021, eLife.

Clinic, pathogenic mechanisms and drug testing of two inherited thrombocytopenias, ANKRD26-related Thrombocytopenia and MYH9-related diseases.

M. Ballmaier, A. Balduini, H. Raslova, 2018, European journal of medical genetics.

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding

D. Tregouet, F. Cambien, C. Perret, 2014, The Journal of experimental medicine.

Lyl-1 regulates primitive macrophages and microglia development

W. Vainchenker, H. Raslova, Anna-Lila Kaushik, 2021, Communications Biology.

Lyl-1 marks and regulates primitive macrophages and microglia development

W. Vainchenker, H. Raslova, Anna-Lila Kaushik, 2020, bioRxiv.

Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy

G. Kroemer, R. Medema, W. Vainchenker, 2004, Oncogene.

DiPRO1 dependent transcriptional and epigenetic regulation distinctly controls the fate of muscle and mesenchymal cancer cells

P. Opolon, H. Raslova, P. Dessen, 2023, bioRxiv.

ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesis

A. Balduini, N. Balayn, W. Vainchenker, 2022, bioRxiv.

ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis

L. Corcos, J. Carroll, H. Raslova, 2021, Leukemia.

Heterozygous and Homozygous JAK2V617F States Modeled by Induced Pluripotent Stem Cells from Myeloproliferative Neoplasm Patients

P. Opolon, Longyun Chen, E. Solary, 2013, PloS one.

Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors

W. Ouwehand, D. Trégouët, P. Morange, 2017, Haematologica.

RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization

D. Bluteau, W. Vainchenker, N. Debili, 2012, Nature Communications.

P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis

W. Vainchenker, N. Debili, H. Raslova, 2016, Oncotarget.

New pathogenic mechanisms induced by germline erythropoietin receptor mutations in primary erythrocytosis

F. Pasquier, W. Vainchenker, H. Raslova, 2017, Haematologica.

New Insights into Mechanisms of Erythropoietin Receptor Mutations in Primary Familial and Congenital Polycythemia

F. Pasquier, W. Vainchenker, H. Raslova, 2016 .

Mutations of the integrin αIIb/β3 intracytoplasmic salt bridge cause macrothrombocytopenia and enlarged platelet α‐granules

P. Nurden, N. Debili, R. Favier, 2018, American journal of hematology.

Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.

D. Bluteau, N. Balayn, E. Solary, 2015, Blood.

P19INK4D links endomitotic arrest and megakaryocyte maturation and is regulated by AML-1.

D. Bluteau, W. Vainchenker, N. Debili, 2008, Blood.

Downregulation of TREM-like transcript-1 and collagen receptor α2 subunit, two novel RUNX1-targets, contributes to platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia

D. Bluteau, N. Balayn, R. Favier, 2018, Haematologica.

MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations.

D. Bluteau, C. Deswarte, G. Leverger, 2012, Blood.

Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients.

W. Vainchenker, N. Debili, R. Favier, 2016, Blood.

Filamin A: key actor in platelet biology.

M. Bryckaert, H. Raslova, J. Rosa, 2019, Blood.

Murine Gammaherpesvirus (MHV) M7 Gene Encoding Glycoprotein 150 (gp150): Difference in the Sequence between 72 and 68 Strains

H. Raslova, K. Mačáková, M. Kúdelová, 2004, Virus Genes.

p19INK4d Controls Hematopoietic Stem Cells in a Cell-Autonomous Manner during Genotoxic Stress and through the Microenvironment during Aging

D. Bluteau, N. Balayn, W. Vainchenker, 2014, Stem cell reports.

Occurrence of human papillomavirus 16 and 18 in smears from the two cervix regions of onco-gynecological patients in Slovakia.

H. Raslova, M. Kúdelová, J. Matis, 2008, Acta virologica.

A gain‐of‐function filamin A mutation in mouse platelets induces thrombus instability

M. Bryckaert, H. Raslova, F. Adam, 2022, Journal of thrombosis and haemostasis : JTH.

Differential Impact of Interferon Alpha on JAK2V617F and Calr Mutated Hematopoietic Stem and Progenitor Cells in Classical MPN

E. Solary, W. Vainchenker, H. Raslova, 2018, Blood.

First case of a human RASGRP2 mutation affecting Rap1 activation in platelets and causing severe bleeding.

F. Cambien, D. Trégouët, C. Perret, 2014 .

CK2: a key regulator of thrombopoiesis.

W. Vainchenker, H. Raslova, 2017, Blood.