S. McKnight

发表

Logic of the Yeast Metabolic Cycle: Temporal Compartmentalization of Cellular Processes

A. Kudlicki, M. Rowicka, B. Tu, 2005, Science.

Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains

R. Tycko, S. McKnight, D. Murray, 2017, Cell.

Restriction of DNA Replication to the Reductive Phase of the Metabolic Cycle Protects Genome Integrity

Steven L McKnight, Benjamin P Tu, B. Tu, 2007, Science.

Altered Patterns of Sleep and Behavioral Adaptability in NPAS2-Deficient Mice

Steven L McKnight, Paul Franken, SiNae Pitts, 2003, Science.

Metabolism and the control of circadian rhythms.

Jared Rutter, Steven L McKnight, S. McKnight, 2002, Annual review of biochemistry.

Regulation of Clock and NPAS2 DNA Binding by the Redox State of NAD Cofactors

Jared Rutter, S. McKnight, J. Rutter, 2001, Science.

Phosphorylation-Regulated Binding of RNA Polymerase II to Fibrous Polymers of Low-Complexity Domains

S. McKnight, Masato Kato, Leeju C. Wu, 2014, Cell.

The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.

S. McKnight, P. Johnson, W. Landschulz, 1988, Science.

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

Jimin Pei, Nick V. Grishin, David Eisenberg, 2012, Cell.

Cell-free Formation of RNA Granules: Bound RNAs Identify Features and Components of Cellular Assemblies

Jimin Pei, Yang Xie, Guanghua Xiao, 2012, Cell.

Gene Switching by Metabolic Enzymes—How Did You Get on the Invitation List?

S. McKnight, Steve McKnight, 2003, Cell.

Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity

S. McKnight, Xiaodong Wang, N. Williams, 2007, Proceedings of the National Academy of Sciences.

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

S. McKnight, D. Russell, H. Tian, 1997, Genes & development.

Transcriptional control signals of a eukaryotic protein-coding gene.

S. McKnight, S L McKnight, R. Kingsbury, 1982, Science.

The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite.

S. McKnight, P. Johnson, W. Landschulz, 1989, Science.

Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression.

S. McKnight, S. Triezenberg, S L McKnight, 1988, Genes & development.

Development of proneurogenic, neuroprotective small molecules.

S. McKnight, S. Estill, N. Williams, 2011, Journal of the American Chemical Society.

Cyclic changes in metabolic state during the life of a yeast cell

Steven L McKnight, Benjamin P Tu, Rachel E. Mohler, 2007, Proceedings of the National Academy of Sciences.

Metabolic cycles as an underlying basis of biological oscillations

B. Tu, S. McKnight, Steven L. McKnight, 2006, Nature Reviews Molecular Cell Biology.

Let the data speak

Andrzej Kudlicki, Maga Rowicka, A. Kudlicki, 2006, Nature Reviews Molecular Cell Biology.

The Structure of GABPα/β: An ETS Domain- Ankyrin Repeat Heterodimer Bound to DNA

Cynthia Wolberger, S. McKnight, C. Wolberger, 1998 .

Pure Genes, Pure Genius

S. McKnight, 2012, Cell.

Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system.

U. Francke, S. McKnight, D. Russell, 1997, Proceedings of the National Academy of Sciences of the United States of America.

CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells.

S. McKnight, A. Friedman, W. Landschulz, 1989, Genes & development.

A genetic approach to promoter recognition during trans induction of viral gene expression.

S. McKnight, D. Coen, S. Weinheimer, 1986, Science.

Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins.

S. McKnight, T. Brown, Thomas A. Brown, 1992, Genes & development.

Functional relationships between transcriptional control signals of the thymidine kinase gene of herpes simplex virus

S. McKnight, 1982, Cell.

Identification of two polypeptide segments of CCAAT/enhancer-binding protein required for transcriptional activation of the serum albumin gene.

S. McKnight, A. Friedman, 1990, Genes & development.

Phosphorylation-Regulated Binding of RNA Polymerase II to Fibrous Polymers of Low-Complexity Domains

S. McKnight, Masato Kato, Leeju C. Wu, 2014, Cell.

A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF

S. McKnight, R. Bruick, Richard K. Bruick, 2001, Science.

Oxygen Sensing Gets a Second Wind

S. McKnight, R. Bruick, Steven L. McKnight, 2002, Science.

ACSS2 promotes systemic fat storage and utilization through selective regulation of genes involved in lipid metabolism

B. Tu, S. McKnight, L. Cai, 2018, Proceedings of the National Academy of Sciences.

Gatekeepers of organ growth.

S. McKnight, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Genetic and physical analysis of the chicken tk gene

M. Groudine, S. McKnight, R. Harland, 1984, Molecular and cellular biology.

Studies on the Regulation of Thymidine Kinase Enzyme Expression

S. McKnight, G. Merrill, D. Coen, 1984 .

tk Enzyme expression in differentiating muscle cells is regulated through an internal segment of the cellular tk gene

S. McKnight, G. Merrill, S. Hauschka, 1984, Molecular and cellular biology.

Mutations linked to neurological disease enhance self-association of low-complexity protein sequences

S. McKnight, Masato Kato, Xiaoming Zhou, 2022, Science.

Redox-mediated regulation of an evolutionarily conserved cross-β structure formed by the TDP43 low complexity domain

S. Ghaemmaghami, B. Tu, S. McKnight, 2020, Proceedings of the National Academy of Sciences.

Passing Through.

S. McKnight, 2019, Trends in biochemical sciences.

Molecular and genetic characterization of GABP beta.

S. McKnight, D. King, L. Rowe, 1994, Genes & development.

How do protein domains of low sequence complexity work?

S. McKnight, Masato Kato, Xiaoming Zhou, 2021, RNA.

Transcriptional and post-transcriptional controls establish the cascade of herpes simplex virus protein synthesis.

S. McKnight, S. Weinheimer, 1987, Journal of molecular biology.

Electron microscopic analysis of chromosome metabolism in the Drosophila melanogaster embryo.

S. McKnight, M. Bustin, O. Miller, 1978, Cold Spring Harbor symposia on quantitative biology.

Oscar Miller (1925–2012)

S. McKnight, J. Gall, A. Beyer, 2012, Science.

Expression of a truncated viral trans-activator selectively impedes lytic infection by its cognate virus

S. McKnight, S. Triezenberg, A. Friedman, 1988, Nature.

Two Distinct High Throughput Screens of PAS Kinase Yield Convergent Insight to Enzyme Function

C. Michnoff, S. McKnight, L. Qin, 2006 .

Cognate DNA binding specificity retained after leucine zipper exchange between GCN4 and C/EBP.

S. McKnight, P. Agre, P. Johnson, 1989, Science.

gene.and physical analysis of the chicken tk

M. Groudine, S. McKnight, R. Harland, 2013 .

Delineation of transcriptional control signals within the Moloney murine sarcoma virus long terminal repeat

S. McKnight, R. Eisenman, B. Graves, 1985, Molecular and cellular biology.

Mammalian sprouty proteins assemble into large monodisperse particles having the properties of intracellular nanobatteries.

S. McKnight, M. Kikkawa, P. Vogel, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins.

S. McKnight, Z. Cao, W. Yeh, 1995, Genes & development.

CCAAT-enhancer binding protein: a component of a differentiation switch.

R. Umek, S. McKnight, A. Friedman, 1991, Science.

Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein.

J. Gordon, S. McKnight, W. Landschulz, 1989, Genes & development.

Scissors-grip model for DNA recognition by a family of leucine zipper proteins.

S. McKnight, P. Sigler, C. Vinson, 1989, Science.

Isolation of a recombinant copy of the gene encoding C/EBP.

S. McKnight, E. Adashi, B. Graves, 1988, Genes & development.

P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases.

S. McKnight, A. Pieper, J. Ready, 2014, Chemical Society reviews.

In situ detection of sequence-specific DNA binding activity specified by a recombinant bacteriophage.

S. McKnight, C. Vinson, P. Johnson, 1988, Genes & development.

The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene.

S. McKnight, 1980, Nucleic acids research.

Eukaryotic transcriptional regulatory proteins.

S. McKnight, P. Johnson, S L McKnight, 1989, Annual review of biochemistry.

Redox State Controls Phase Separation of the Yeast Ataxin-2 Protein via Reversible Oxidation of Its Methionine-Rich Low-Complexity Domain

B. Tu, S. McKnight, Masato Kato, 2019, Cell.

Transcriptional selectivity of viral genes in mammalian cells

Robert Tjian, Steven McKnight, R. Tjian, 1986, Cell.

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

R. Umek, S. McKnight, Z. Cao, 1991, Genes & development.

Convergence of Ets- and notch-related structural motifs in a heteromeric DNA binding complex.

S. McKnight, T. Brown, C. Thompson, 1991, Science.

Identification, cloning and sequencing of the HSV thymidine kinase genes

S. McKnight, G. Reyes, G. Hayward, 1981 .

Expression of the herpes thymidine kinase gene in Xenopus laevis oocytes: an assay for the study of deletion mutants constructed in vitro.

S. McKnight, E. R. Gavis, 1980, Nucleic acids research.

Discovery of antivirals against smallpox.

H. Fineberg, B. Alberts, B. Moss, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Ultrastructural patterns of RNA synthesis during early embryogenesis of Drosophila melanogaster

S. McKnight, O. Miller, 1976, Cell.

Evidence of DNA: protein interactions that mediate HSV-1 immediate early gene activation by VP16.

S. McKnight, S. Triezenberg, K. Lamarco, 1988, Genes & development.

Chapter IV – Transcriptional Units in Eukaryotic Chromosomes

S. McKnight, O. Miller, A. Beyer, 1979 .

Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses.

S. McKnight, B. Graves, P. Johnson, 1987, Genes & development.

Homologous recognition of a promoter domain common to the MSV LTR and the HSV tk gene

S. McKnight, B. Graves, Peter F. Johnson, 1986, Cell.

Identification of Ets- and notch-related subunits in GA binding protein.

S. McKnight, B. Byers, K. Lamarco, 1991, Science.

Electron microscopic analysis of chromatin replication in the cellular blastoderm drosophila melanogaster embryo

S. McKnight, O. Miller, 1977, Cell.

Is CCAAT/enhancer-binding protein a central regulator of energy metabolism?

R. Jaenisch, S. McKnight, M. Lane, 1989, Genes & development.

Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors.

Carol Dudley, Steven L McKnight, Ramon Diaz-Arrastia, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells

S. McKnight, Tao Wang, Yang Xie, 2014, Science.

Coordinate Regulation of Sugar Flux and Translation by PAS Kinase

S. McKnight, J. Rutter, B. Probst, 2002, Cell.

Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: Identification of an upstream control region

R. Axel, S. McKnight, E. R. Gavis, 1981, Cell.

Acetate Dependence of Tumors

R. Hammer, B. Tu, S. McKnight, 2014, Cell.

Influence of Metabolism on Epigenetics and Disease

W. Kaelin, S. McKnight, Steven L. McKnight, 2013, Cell.

Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism

R. Hammer, S. McKnight, O. Cleaver, 2009, Science.

Purification of a set of cellular polypeptides that bind to the purine-rich cis-regulatory element of herpes simplex virus immediate early genes.

S. McKnight, K. Lamarco, K. L. Lamarco, 1989, Genes & development.

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development.

R. Hammer, S. McKnight, D. Russell, 1998, Genes & development.

Redox-mediated regulation of low complexity domain self-association.

B. Tu, S. McKnight, Masato Kato, 2021, Current opinion in genetics & development.

Phosphorylation-Regulated Binding of RNA Polymerase II to Fibrous Polymers of Low-Complexity Domains

S. McKnight, Masato Kato, Leeju C. Wu, 2013, Cell.

Ribonucleoprotein structure in nascent hnRNA is nonrandom and sequence-dependent

S. McKnight, O. Miller, A. Beyer, 1980, Cell.

29 CCAAT/Enhancer Binding Protein

S. McKnight, 1992 .

The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice.

D. Brat, S. McKnight, J. Richardson, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Back to the future: molecular biology meets metabolism.

S. McKnight, 2011, Cold Spring Harbor symposia on quantitative biology.

Identification and purification of human Stat proteins activated in response to interleukin-2.

S. McKnight, W. Henzel, S. Wong, 1995, Immunity.

Alternate utilization of two regulatory domains within the Moloney murine sarcoma virus long terminal repeat

S. McKnight, B. Graves, D. Coen, 1985, Molecular and cellular biology.

Promoter domains required for expression of plasmid-borne copies of the herpes simplex virus thymidine kinase gene in virus-infected mouse fibroblasts and microinjected frog oocytes

S. McKnight, D. Coen, S. Eisenberg, 1985, Molecular and cellular biology.

Building better vasculature.

S. McKnight, R. Bruick, S L McKnight, 2001, Genes & development.

An interleukin-4-induced transcription factor: IL-4 Stat.

S. McKnight, W. Henzel, U. Schindler, 1994, Science.

Components of a Stat recognition code: evidence for two layers of molecular selectivity.

S. McKnight, M. Rothe, U. Schindler, 1995, Immunity.

A Solid-State Conceptualization of Information Transfer from Gene to Message to Protein.

Masato Kato, Steven L McKnight, S. McKnight, 2018, Annual review of biochemistry.

The LC Domain of hnRNPA2 Adopts Similar Conformations in Hydrogel Polymers, Liquid-like Droplets, and Nuclei

Yonghao Yu, Siheng Xiang, S. McKnight, 2015, Cell.

Structural characterization of the D290V mutation site in hnRNPA2 low-complexity–domain polymers

R. Tycko, S. McKnight, Masato Kato, 2018, Proceedings of the National Academy of Sciences.

Transiently structured head domains control intermediate filament assembly

R. Tycko, S. McKnight, Masato Kato, 2020, Proceedings of the National Academy of Sciences.

Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers

S. McKnight, Masato Kato, Yi Lin, 2016, Cell.

NPAS2: A Gas-Responsive Transcription Factor

S. McKnight, M. Gilles-Gonzalez, J. Rutter, 2002, Science.

Cross-β Polymerization of Low Complexity Sequence Domains.

S. McKnight, Masato Kato, 2017, Cold Spring Harbor perspectives in biology.

Toxic PRn poly-dipeptides encoded by the C9orf72 repeat expansion block nuclear import and export

S. McKnight, J. Gall, Masato Kato, 2017, Proceedings of the National Academy of Sciences.

Glimpses of allostery in the control of eukaryotic gene expression.

S. McKnight, F. C. de la Brousse, 1993, Trends in genetics : TIG.

Evidence of carbon monoxide-mediated phase advancement of the yeast metabolic cycle

B. Tu, S. McKnight, 2009, Proceedings of the National Academy of Sciences.

The yeast metabolic cycle: insights into the life of a eukaryotic cell.

B. Tu, S. McKnight, B P Tu, 2007, Cold Spring Harbor symposia on quantitative biology.

Molecular zippers in gene regulation.

S. McKnight, S L McKnight, 1991, Scientific American.

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis

S. McKnight, S. Estill, N. Williams, 2012, Proceedings of the National Academy of Sciences.

The distal transcription signals of the herpesvirus tk gene share a common hexanucleotide control sequence

S. McKnight, Michael B. Smith, A. Spence, 1984, Cell.

Transcription revisited: a commentary on the 1995 Cold Spring Harbor Laboratory meeting, "Mechanisms of Eukaryotic Transcription".

S. McKnight, 1996, Genes & development.

Post-replicative nonribosomal transcription units in D. melanogaster embryos

S. McKnight, O. Miller, 1979, Cell.

Differentiation of T‐helper lymphocytes: selective regulation by members of the STAT family of transcription factors

S. McKnight, T. Hoey, U. Schindler, 1996, Genes to cells : devoted to molecular & cellular mechanisms.

NPAS2: An Analog of Clock Operative in the Mammalian Forebrain

S. McKnight, M. Reick, Joseph A Garcia, 2001, Science.

Accurate transcription of cloned Xenopus rRNA genes by RNA polymerase I: demonstration by S1 nuclease mapping.

S. McKnight, B. Sollner-Webb, B. Sollner‐Webb, 1982, Nucleic acids research.

McBindall—A Better Name for CCAAT/Enhancer Binding Proteins?

S. McKnight, 2001, Cell.

P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage

S. McKnight, D. Nijhawan, Pano Theodoropoulos, 2014, Cell.

A Conserved DNA Damage Response Pathway Responsible for Coupling the Cell Division Cycle to the Circadian and Metabolic Cycles

S. McKnight, Zheng Chen, 2007, Cell cycle.

PAS kinase: An evolutionarily conserved PAS domain-regulated serine/threonine kinase

K. Gardner, C. Michnoff, S. McKnight, 2001, Proceedings of the National Academy of Sciences of the United States of America.

WAT-free mice: diabetes without obesity.

S. McKnight, 1998, Genes & development.

Discovery of a Proneurogenic, Neuroprotective Chemical

D. Brat, S. McKnight, Ching-Han Shen, 2010, Cell.

The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA.

S. McKnight, C. Wolberger, A. Batchelor, 1998, Science.

Anatomy of an enhancer

S. McKnight, C. Thompson, 1992 .

Visualization of the silk fibroin transcription unit and nascent silk fibroin molecules on polyribosomes of Bombyx mori.

S. McKnight, O. Miller, N. Sullivan, 1976, Progress in nucleic acid research and molecular biology.

Benefits of Enhancing Nicotinamide Adenine Dinucleotide Levels in Damaged or Diseased Nerve Cells.

S. McKnight, A. Pieper, 2019, Cold Spring Harbor symposia on quantitative biology.

Redox-mediated regulation of a labile, evolutionarily conserved cross-β structure formed by the TDP43 low complexity domain

S. Ghaemmaghami, B. Tu, S. McKnight, 2019, bioRxiv.

Impaired cued and contextual memory in NPAS2-deficient mice.

M Reick, C. Michnoff, S. McKnight, 2000, Science.

NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: genotype and sex interactions.

S. McKnight, P. Franken, B. O’Hara, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Evidence of changes in protease sensitivity and subunit exchange rate on DNA binding by C/EBP.

S. McKnight, C. Vinson, J. Shuman, 1990, Science.

Tissue-Specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/ennancer binding protein

J. Gordon, S. McKnight, W. Landschulz, 2007 .

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease

S. McKnight, S. Estill, N. Williams, 2012, Proceedings of the National Academy of Sciences.

Phosphorylation of CCAAT-enhancer binding protein by protein kinase C attenuates site-selective DNA binding.

S. McKnight, K. Huang, J. Shuman, 1992, The Journal of biological chemistry.

Cross-β polymerization and hydrogel formation by low-complexity sequence proteins.

S. McKnight, Masato Kato, Yi Lin, 2017, Methods.

Please keep me 2uned to PKM2.

S. McKnight, 2014, Molecular cell.

On Getting There from Here

S. McKnight, 2010, Science.

Metabolic Specialization of Mouse Embryonic Stem Cells

S. McKnight, 2012, Cold Spring Harbor symposia on quantitative biology.

P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury.

A. Bassuk, S. McKnight, J. Shao, 2014, Cell reports.

Immunological cross-reaction between calf and Drosophila histones.

S. McKnight, M. Bustin, R. Reeder, 1977, The Journal of biological chemistry.

The low-complexity domain of the FUS RNA binding protein self-assembles via the mutually exclusive use of two distinct cross-β cores

S. McKnight, Masato Kato, 2021, Proceedings of the National Academy of Sciences.

A hypothetical means of treating or preventing cancer

S. McKnight, 2014, Cancer & Metabolism.

Targeted killing of a mammalian cell based upon its specialized metabolic state

S. McKnight, Peter B. Alexander, Jian Wang, 2011, Proceedings of the National Academy of Sciences.

Dynamic structural order of a low-complexity domain facilitates assembly of intermediate filaments

S. McKnight, Masato Kato, L. Sutherland, 2020, Proceedings of the National Academy of Sciences.

Molecular and genetic characterization of GABPI3

S. McKnight, D. King, L. Rowe, 1994 .

Ultrastructural analysis of ribosomal gene transcription in vitro.

R. Hipskind, S. McKnight, R. Reeder, 1980, The Journal of biological chemistry.

Functional Anatomy of the TDP-43 Redox Sensor

S. McKnight, Xiaoming Zhou, G. Liszczak, 2021, bioRxiv.

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

S. McKnight, D. Russell, S. McKnight, 1997, Genes & development.

Concerted effort: oscillations in global gene expression during nematode development.

B. Tu, S. McKnight, Sunil Laxman, 2014, Molecular cell.

Diversity and specificity in transcriptional regulation: the benefits of heterotypic dimerization.

S. McKnight, P Lamb, S L McKnight, 1991, Trends in biochemical sciences.

Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: Identification of an upstream control region

R. Axel, S. McKnight, E. R. Gavis, 1981, Cell.

Phosphorylation-Regulated Binding of RNA Polymerase II to Fibrous Polymers of Low-Complexity Domains

S. McKnight, Masato Kato, Leeju C. Wu, 2013, Cell.