Hayley S. Brown

发表

Prediction of in vivo drug-drug interactions from in vitro data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant.

Hayley S. Brown, Kiyomi Ito, A. Galetin, 2005, British journal of clinical pharmacology.

Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies

Hayley S. Brown, J. Houston, D. Hallifax, 2007, Drug metabolism reviews.

Achieving improved permeability by hydrogen bond donor modulation in a series of MGAT2 inhibitors

Philip A. MacFaul, Graeme R. Robb, Andrew G. Leach, 2013 .

COMPARATIVE USE OF ISOLATED HEPATOCYTES AND HEPATIC MICROSOMES FOR P450 INHIBITION STUDIES: TRANSPORTER-ENZYME INTERPLAY

Hayley S. Brown, J. Brian, Alison J. Wilby, 2010 .

Circumventing seizure activity in a series of G protein coupled receptor 119 (GPR119) agonists.

Hayley S. Brown, D. Laber, James S. Scott, 2014, Journal of medicinal chemistry.

Conformational restriction in a series of GPR119 agonists: differences in pharmacology between mouse and human.

Hayley S. Brown, D. Laber, James S. Scott, 2013, Bioorganic & medicinal chemistry letters.

Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation.

Andrew G. Leach, Hayley S. Brown, D. Laber, 2012, Journal of medicinal chemistry.

Discovery, optimisation and in vivo evaluation of novel GPR119 agonists.

Andrew G. Leach, Hayley S. Brown, James S. Scott, 2011, Bioorganic & medicinal chemistry letters.

Prediction of In Vivo Drug-Drug Interactions from In Vitro Data

Aleksandra Galetin, J Brian Houston, Hayley S. Brown, 2006, Clinical pharmacokinetics.

Use of Isolated Hepatocyte Preparations for Cytochrome P450 Inhibition Studies: Comparison with Microsomes for Ki Determination

Hayley S. Brown, J. Houston, A. Chadwick, 2007, Drug Metabolism and Disposition.

Database analyses for the prediction of in vivo drug-drug interactions from in vitro data.

Kiyomi Ito, J Brian Houston, Hayley S. Brown, 2004, British journal of clinical pharmacology.

Evaluation of Cryopreserved Human Hepatocytes as an Alternative in Vitro System to Microsomes for the Prediction of Metabolic Clearance

J Brian Houston, Hayley S. Brown, J. Houston, 2007, Drug Metabolism and Disposition.

Characteristics and outcomes of elderly patients with primary central nervous system lymphoma

L. Deangelis, Hayley S. Brown, A. Reiner, 2010, Cancer.

Comparative Use of Isolated Hepatocytes and Hepatic Microsomes for Cytochrome P450 Inhibition Studies: Transporter-Enzyme Interplay

Hayley S. Brown, J. Houston, M. Ohta, 2010, Drug Metabolism and Disposition.

DMD # 35824 1 COMPARATIVE USE OF ISOLATED HEPATOCYTES AND HEPATIC MICROSOMES FOR P 450 INHIBITION STUDIES : TRANSPORTER-ENZYME INTERPLAY

Hayley S. Brown, J. Brian, Alison J. Wilby, 2010 .

Use of Isolated Hepatocyte Preparations for Cytochrome P450 Inhibition Studies: Comparison with Microsomes for Ki Determination

Hayley S. Brown, J. Houston, B. Houston, 2007, Drug Metabolism and Disposition.

Optimisation of aqueous solubility in a series of G protein coupled receptor 119 (GPR119) agonists

Andrew G. Leach, Hayley S. Brown, James S. Scott, 2013 .

Circumventing seizure activity in a series of G protein coupled receptor 119 (GPR119) agonists.

Andrew G. Leach, Hayley S. Brown, D. Laber, 2014, Journal of medicinal chemistry.

USE OF ISOLATED HEPATOCYTE PREPARATIONS FOR P 450 INHIBITION STUDIES : COMPARISON WITH MICROSOMES FOR KI DETERMINATION

Hayley S. Brown, J. Houston, A. Chadwick, 2007 .