Kiyomi Ito

K. Maeda, Y. Sugiyama, Kiyomi Ito, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Effects of magnesium sulphate administration on aquaporin 3 in rat gastrointestinal tract.

Kiyomi Ito, M. Ishii, N. Ikarashi, 2011, Biological & pharmaceutical bulletin.

Estimation of changes in serum creatinine and creatinine clearance caused by renal transporter inhibition in healthy subjects.

H. Kusuhara, Kiyomi Ito, T. Kudo, 2019, Drug metabolism and pharmacokinetics.

Which concentration of the inhibitor should be used to predict in vivo drug interactions from in vitro data?

Yuichi Sugiyama, Motohiro Kato, Koji Chiba, 2002, AAPS PharmSci.

Pharmacokinetics and safety of rilpivirine in healthy Japanese subjects and exploration of ethnic sensitivity of rilpivirine pharmacokinetics with physiologically based pharmacokinetic model approach.

Kiyomi Ito, H. Tanii, H. Crauwels, 2021, Drug metabolism and pharmacokinetics.

Use of a Physiologically Based Pharmacokinetic Model for Quantitative Prediction of Drug-Drug Interactions via CYP3A4 and Estimation of the Intestinal Availability of CYP3A4 Substrates.

Y. Sugiyama, Kiyomi Ito, Yoko Mano, 2015, Journal of pharmaceutical sciences.

DMD049460 362..371

Y. Sugiyama, Kiyomi Ito, T. Kudo, 2013 .

Inhibition of In Vitro Metabolism of Simvastatin by Itraconazole in Humans and Prediction of In Vivo Drug-Drug Interactions

Y. Sugiyama, Kiyomi Ito, T. Kondo, 2001, Pharmaceutical Research.

Effect of buffer conditions on CYP2C8-mediated paclitaxel 6α-hydroxylation and CYP3A4-mediated triazolam α- and 4-hydroxylation by human liver microsomes

Kiyomi Ito, T. Kudo, H. Goda, 2016, Xenobiotica; the fate of foreign compounds in biological systems.

QUANTITATIVE PREDICTION: METABOLISM, TRANSPORT IN THE LIVER

Y. Sugiyama, Kiyomi Ito, 1999 .

In Vitro/in Vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans

Y. Sugiyama, Kiyomi Ito, C. Tyson, 2001, Biopharmaceutics & drug disposition.

Analysis of the Repaglinide Concentration Increase Produced by Gemfibrozil and Itraconazole Based on the Inhibition of the Hepatic Uptake Transporter and Metabolic Enzymes

Yuichi Sugiyama, Akihiro Hisaka, Kiyomi Ito, 2013, Drug Metabolism and Disposition.

Effects of Kampo medicines on P-glycoprotein.

Kiyomi Ito, N. Ikarashi, K. Sugiyama, 2009, Biological & pharmaceutical bulletin.

Quantitative Prediction of In Vivo Drug-Drug Interactions from In Vitro Data Based on Physiological Pharmacokinetics: Use of Maximum Unbound Concentration of Inhibitor at the Inlet to the Liver

Yuichi Sugiyama, Kiyomi Ito, Y. Sugiyama, 2000, Pharmaceutical Research.

Effects of Intestinal CYP3A4 and P-Glycoprotein on Oral Drug Absorption—Theoretical Approach

Yuichi Sugiyama, Hiroyuki Kusuhara, Kiyomi Ito, 1999, Pharmaceutical Research.

Comparative studies to determine the selective inhibitors for P-glycoprotein and cytochrome P 4503A4

Y. Sugiyama, Kiyomi Ito, Hiroshi Suzuki, 1999, AAPS PharmSci.

Quantitative analysis of elevation of serum creatinine via renal transporter inhibition by trimethoprim in healthy subjects using physiologically-based pharmacokinetic model.

H. Kusuhara, Kiyomi Ito, T. Kudo, 2017, Drug metabolism and pharmacokinetics.

Anti-Obesity and Anti-Diabetic Effects of Acacia Polyphenol in Obese Diabetic KKAy Mice Fed High-Fat Diet

Kiyomi Ito, N. Ikarashi, T. Toda, 2011, Evidence-based complementary and alternative medicine : eCAM.

Ciprofloxacin suppresses Cyp3a in mouse liver by reducing lithocholic acid-producing intestinal flora.

Kiyomi Ito, N. Ikarashi, T. Toda, 2009, Drug metabolism and pharmacokinetics.

Effects of Kampo medicines on Cyp3a and P-glycoprotein activity in vivo

Kiyomi Ito, N. Ikarashi, K. Sugiyama, 2009 .

Inclusion of human intravenous study data in new drug applications-impact of the Japanese guidance.

Y. Sugiyama, Kiyomi Ito, M. Kusama, 2012, Journal of pharmaceutical sciences.

Study of the Inhibitory Effects of Enteral Nutrition Formula on Indomethacin-Induced Gastric Lesions in Mice

Kiyomi Ito, Takeshi Yoshimi, M. Suda, 2019, Nutrients.

The Inhibition of Lipase and Glucosidase Activities by Acacia Polyphenol

Kiyomi Ito, N. Ikarashi, W. Ochiai, 2011, Evidence-based complementary and alternative medicine : eCAM.

Comparative study of effects of angiotensin II receptor antagonist, KD3-671, and angiotensin converting enzyme inhibitor, enalaprilat, on cough reflex in guinea pig

Kaori Ito, Kiyomi Ito, Y. Sawada, 2010, European Journal of Drug Metabolism and Pharmacokinetics.

Metronidazole reduces the expression of cytochrome P450 enzymes in HepaRG cells and cryopreserved human hepatocytes

Kiyomi Ito, T. Kudo, Y. Endo, 2015, Xenobiotica; the fate of foreign compounds in biological systems.

Investigation of the safety of topical metronidazole from a pharmacokinetic perspective.

Kiyomi Ito, T. Kudo, Toru Sato, 2013, Biological & pharmaceutical bulletin.

How to Manage Drug Interactions in Clinical Settings (1)

Kiyomi Ito, A. Yonezawa, A. Hisaka, 2018, Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences).

A mechanism by which the osmotic laxative magnesium sulphate increases the intestinal aquaporin 3 expression in HT-29 cells.

Kiyomi Ito, M. Ishii, N. Ikarashi, 2011, Life sciences.

Sex difference in inhibition of in vitro mexazolam metabolism by various 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors in rat liver microsomes.

Y. Sugiyama, Kiyomi Ito, W. Takasaki, 2002, Drug metabolism and disposition: the biological fate of chemicals.

IMPACT OF PARALLEL PATHWAYS OF DRUG ELIMINATION AND MULTIPLE CYTOCHROME P450 INVOLVEMENT ON DRUG-DRUG INTERACTIONS: CYP2D6 PARADIGM

Kiyomi Ito, J Brian Houston, Kiyomi Ito, 2005, Drug Metabolism and Disposition.

Database analyses for the prediction of in vivo drug-drug interactions from in vitro data.

Kiyomi Ito, J Brian Houston, Hayley S. Brown, 2004, British journal of clinical pharmacology.

Antibiotics suppress Cyp3a in the mouse liver by reducing lithocholic acid-producing intestinal flora.

Kiyomi Ito, N. Ikarashi, T. Toda, 2009, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Byakkokaninjinto prevents body water loss by increasing the expression of kidney aquaporin‐2 and skin aquaporin‐3 in KKAy mice

Kiyomi Ito, K. Miyamoto, N. Ikarashi, 2011, Phytotherapy research : PTR.

The role of renal aquaporin 2 in the alleviation of dehydration associated with diabetic polyuria in KKAy mice.

Kiyomi Ito, N. Ikarashi, T. Toda, 2010, Life sciences.

Determination of a Human Hepatic Microsomal Scaling Factor for Predicting in Vivo Drug Clearance

Kiyomi Ito, J. Houston, R. Edwards, 2006, Pharmaceutical Research.

Prediction of Human Drug Clearance from in Vitro and Preclinical Data Using Physiologically Based and Empirical Approaches

Kiyomi Ito, Kiyomi Ito, J. Houston, 2004, Pharmaceutical Research.

How to Manage Drug Interactions in Clinical Settings (3)

Kiyomi Ito, A. Yonezawa, A. Hisaka, 2018, Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences).

Classification of drugs for evaluating drug interaction in drug development and clinical management.

K. Maeda, Kiyomi Ito, A. Hisaka, 2021, Drug metabolism and pharmacokinetics.

Comparison of the Use of Liver Models for Predicting Drug Clearance Using in Vitro Kinetic Data from Hepatic Microsomes and Isolated Hepatocytes

Kiyomi Ito, Kiyomi Ito, J. Houston, 2004, Pharmaceutical Research.

Adam S. Hayward, C. Meyer, S. Dooley, 2013, Archives of Toxicology.

Survey of the Present Problems Preventing the Spread of Generic Drugs

Kiyoshi Sugiyama, Kiyomi Ito, Kiyomi Ito, 2005 .

Prediction of the in vivo interaction between midazolam and macrolides based on in vitro studies using human liver microsomes.

Kiyomi Ito, Kiyomi Ito, Tomoo Itoh, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Delayed Neonatal Closure of the Ductus Arteriosus Following Early in utero Exposure to Indomethacin in the Rat

Kiyomi Ito, T. Nakanishi, K. Sugiyama, 2009, Neonatology.

Gastroprotective Effect of Enteral Nutrition Formula in Mice Injected Subcutaneously with Indomethacin

Kiyomi Ito, T. Kudo, Y. Yamagishi, 2021, Nutrients.

Chorea-like symptoms and high blood concentration of ceftriaxone in a patient undergoing hemodialysis: A case report.

Kiyomi Ito, T. Kudo, H. Goda, 2020, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

In vitro–in vivo extrapolation of metabolic clearance using human liver microsomes: factors showing variability and their normalization

Kiyomi Ito, T. Kudo, K. Morita, 2020, Xenobiotica; the fate of foreign compounds in biological systems.

Inhibitory Effects of Daiokanzoto (Da-Huang-Gan-Cao-Tang) on P-Glycoprotein

Kiyomi Ito, N. Ikarashi, W. Ochiai, 2012, Evidence-based complementary and alternative medicine : eCAM.

Prediction of the therapeutic dose for β-stimulants based on preclinical data: Application of oral dosage forms and aerosols to asthmatic patients

Kiyomi Ito, Y. Sawada, T. Iga, 1993, Journal of Pharmacokinetics and Biopharmaceutics.

How to Manage Drug Interactions in Clinical Settings (2)

Kiyomi Ito, A. Yonezawa, A. Hisaka, 2018, Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences).

Effects of Kampo medicines on CYP and P-gp activity in vitro.

Kiyomi Ito, N. Ikarashi, K. Sugiyama, 2008, Biological & pharmaceutical bulletin.

Evaluation of the appropriate time range for estimating the apparent permeability coefficient (P(app)) in a transcellular transport study.

Kiyomi Ito, T. Kudo, Kazuhisa Ozeki, 2015, International journal of pharmaceutics.

Prediction of Oral Absorption of Cephalosporins in Humans

Kiyomi Ito, H. Yamada, Y. Shitara, 2000 .

Classification of benzodiazepine hypnotics in humans based on receptor occupancy theory

Kiyomi Ito, Y. Sawada, T. Iga, 1993, Journal of Pharmacokinetics and Biopharmaceutics.

UTILITY OF RECOMBINANT ENZYME KINETICS IN PREDICTION OF HUMAN CLEARANCE: IMPACT OF VARIABILITY, CYP3A5, AND CYP2C19 ON CYP3A4 PROBE SUBSTRATES

Aleksandra Galetin, Kiyomi Ito, J Brian Houston, 2004, Drug Metabolism and Disposition.

Risk assessment of adverse pulmonary effects induced by adrenaline β-receptor antagonists and rational drug dosage regimen based on receptor occupancy

Kiyomi Ito, Y. Sawada, T. Iga, 1995, Journal of Pharmacokinetics and Biopharmaceutics.

Prediction of Therapeutic Doses of Antipsychotic Drugs as Dopamine D2 Receptor Antagonists : Approach Based on Receptor Occupancy Theory

Kiyomi Ito, Y. Sawada, T. Iga, 1993 .

Pharmacokinetics of CuGTSM, a Novel Drug Candidate, in a Mouse Model of Menkes Disease

Kiyomi Ito, H. Kodama, T. Kudo, 2021, Pharmaceutical Research.

Comparison of the Pravastatin Original and Generic Drugs in the Simple Suspension Method

Kiyomi Ito, N. Ikarashi, K. Sugiyama, 2008 .

Efficacy of Low-dose Aspirin Therapy: Stability of Aspirin Suspended together with Alkaline Agents by the Simple Suspension Method

Kiyomi Ito, N. Ikarashi, W. Ochiai, 2010 .

Stability of Drugs when Prepared for Tube Administration by Simple Suspension Method

Kiyomi Ito, N. Ikarashi, K. Sugiyama, 2006 .

Prediction of In Vivo Interaction Between Triazolam and Erythromycin Based on In Vitro Studies Using Human Liver Microsomes and Recombinant Human CYP3A4

Y. Sugiyama, Kiyomi Ito, C. Tyson, 2000, Pharmaceutical Research.

Survey of the Use of Kampo Medicine at the Kampo Clinic-Patents' Perceptions and Compliance Regarding Kampo Medicines-

Motoko Fukuzawa, Kenji Watanabe, Kiyoshi Sugiyama, 2009 .

The intestinal first-pass metabolism of substrates of CYP3A4 and P-glycoprotein-quantitative analysis based on information from the literature.

H. Kusuhara, Y. Sugiyama, Kiyomi Ito, 2003, Drug metabolism and pharmacokinetics.

Translatability of in vitro potency to clinical efficacious exposure: A retrospective analysis of FDA‐approved targeted small molecule oncology drugs

Kiyomi Ito, N. Kotani, 2023, Clinical and translational science.

UTILITY OF RECOMBINANT ENZYME KINETICS IN PREDICTION OF HUMAN CLEARANCE : IMPACT OF VARIABILITY , CYP 3 A 5 , AND CYP 2 C 19 ON CYP 3 A 4 PROBE SUBSTRATES

Kiyomi Ito, A. Galetin, J. Houston, 2004 .

Quantitative Prediction of In Vivo Drug-drug Interactions from In Vitro Data : Effects of Active Transport of Inhibitors into the Liver

Y. Sugiyama, Kiyomi Ito, T. Iwatsubo, 2000 .

Quantitative Consideration of Clinical Increases in Serum Creatinine Caused by Renal Transporter Inhibition

Kiyomi Ito, T. Kudo, T. Nakada, 2023, Drug Metabolism and Disposition.

Model-based determination of abatacept exposure in support of the recommended dose for Japanese rheumatoid arthritis patients

Kiyomi Ito, A. Roy, Mayumi Hasegawa, 2011, Journal of Pharmacokinetics and Pharmacodynamics.

GLYCOPROTEIN BY VALSPODAR IN GENE TRANSFECTANT SYSTEMS

Y. Sugiyama, Kiyomi Ito, Y. Kato, 2000 .

Effects of serum albumin and liver cytosol on CYP2C9- and CYP3A4-mediated drug metabolism.

Y. Sugiyama, Kiyomi Ito, Y. Ohno, 2002, Drug metabolism and pharmacokinetics.

Quantitative Prediction of Drug Interation Involving Metabolism and Transport in the Liver

Y. Sugiyama, Kiyomi Ito, Y. Kato, 2000 .

Preparation of a Clonidine Ointment and its Application to Sympathetically Maintained Pain (SMP)

Kiyomi Ito, N. Ikarashi, K. Sugiyama, 2007 .

Preparation of Local Anesthetic Ointments for Home Care Patients with Post Herpetic Neuralgia. (1). Effects of Lipid Solubility of Local Anesthetics and Ointment Bases on Analgesic Effects.

Kiyomi Ito, H. Kotaki, Y. Sawada, 1998 .

Disposition of a new tamibarotene prodrug in mice.

Kiyomi Ito, K. Shudo, N. Ikarashi, 2009, Biological & pharmaceutical bulletin.

Use of clearance concepts and modeling techniques in the prediction of metabolic drug-drug interactions.

Y. Sugiyama, Kiyomi Ito, 2010, Trends in pharmacological sciences.

Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver.

Y. Sugiyama, Kiyomi Ito, T. Iwatsubo, 1998, Pharmacological reviews.

Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport.

Y. Sugiyama, Kiyomi Ito, T Iwatsubo, 1998, Annual review of pharmacology and toxicology.

A comparison of the effects of 3-hydroxy-3-methylglutaryl-coenzyme a (HMG-CoA) reductase inhibitors on the CYP3A4-dependent oxidation of mexazolam in vitro.

Y. Sugiyama, Kiyomi Ito, W. Takasaki, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Special Section on Mechanism-Based Predictive Methods in Drug Discovery and Development — Minireview Quantitative Consideration of Clinical Increases in Serum Creatinine Caused by Renal Transporter Inhibition S

Kiyomi Ito, T. Kudo, Tomohisa Nakada, 2023 .

A comparison of the effects of 3-hydroxy-3-methylglutaryl-coenzyme a (HMG-CoA) reductase inhibitors on the CYP3A4-dependent oxidation of mexazolam in vitro.

Y. Sugiyama, Kiyomi Ito, W. Takasaki, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Selective inhibition of human cytochrome P450 3A4 by N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-(1, 1-dimethylethylaminocarbonyl)-4-[(furo[2, 3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethy lpentanamide and P-glycoprotein by valspodar in gene transfectant systems.

Y. Sugiyama, Kiyomi Ito, Y. Kato, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Evaluation of methods for predicting drug-drug interactions by Monte Carlo simulation.

Y. Sugiyama, Kiyomi Ito, Tatsuhiko Tachibana, 2003, Drug metabolism and pharmacokinetics.

Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes (292.2)

Kiyomi Ito, T. Kudo, A. Hisaka, 2014 .

Altered expression of CYP in TSOD mice: a model of type 2 diabetes and obesity

Kiyomi Ito, T. Shimada, M. Aburada, 2009, Xenobiotica; the fate of foreign compounds in biological systems.

Drug interaction between simvastatin and itraconazole in male and female rats.

Y. Sugiyama, Kiyomi Ito, W. Takasaki, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Decreased Cyciosporine Absorption after Treatment with Golytely Lavage Solution in a Kidney Transplant Patient

Kiyomi Ito, H. Kotaki, Koujirou Yamamoto, 1994, The Annals of pharmacotherapy.

Catalepsy Induced by Manidipine, a Calcium Channel Blocker, in Mice

Kiyomi Ito, Y. Sawada, T. Iga, 1996, The Journal of pharmacy and pharmacology.

Bridging from preclinical to clinical studies for tyrosine kinase inhibitors based on pharmacokinetics/pharmacodynamics and toxicokinetics/toxicodynamics.

Kiyomi Ito, T. Kudo, M. Ishigai, 2011, Drug metabolism and pharmacokinetics.

Relationship between Reversal of Flunitrazepam-Induced Sedation by Flumazenil and Benzodiazepine Receptor Occupancy

Kiyomi Ito, Y. Sawada, T. Iga, 1994 .