J. Houston

发表

Prediction of in vivo drug-drug interactions from in vitro data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant.

Hayley S. Brown, Kiyomi Ito, A. Galetin, 2005, British journal of clinical pharmacology.

CYP3A4 Substrate Selection and Substitution in the Prediction of Potential Drug-Drug Interactions

Kiyomi Ito, A. Galetin, J. Houston, 2005, Journal of Pharmacology and Experimental Therapeutics.

In vitro cytochrome P450 inhibition data and the prediction of drug‐drug interactions: Qualitative relationships, quantitative predictions, and the rank‐order approach

J. Houston, R. Obach, R. Walsky, 2005, Clinical pharmacology and therapeutics.

The Utility of in Vitro Cytochrome P450 Inhibition Data in the Prediction of Drug-Drug Interactions

J. Houston, R. Obach, R. Walsky, 2006, Journal of Pharmacology and Experimental Therapeutics.

Optimizing Drug Development: Strategies to Assess Drug Metabolism/Transporter Interaction Potential—Toward a Consensus

Shiew-Mei Huang, J. Houston, G. Tucker, 2001, Pharmaceutical Research.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Adam S. Hayward, C. Meyer, S. Dooley, 2013, Archives of Toxicology.

Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies

Hayley S. Brown, J. Houston, D. Hallifax, 2007, Drug metabolism reviews.

Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

John C Lipscomb, Amin Rostami-Hodjegan, Alan R Boobis, 2007, Current drug metabolism.

Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential--towards a consensus.

J B Houston, Shiew-Mei Huang, J. Houston, 2001, British journal of clinical pharmacology.

Physiologically Based Pharmacokinetic Modeling of Intestinal First-Pass Metabolism of CYP3A Substrates with High Intestinal Extraction

Michael Gertz, Aleksandra Galetin, J Brian Houston, 2011, Drug Metabolism and Disposition.

Evaluation of Recombinant Cytochrome P450 Enzymes as an in Vitro System for Metabolic Clearance Predictions

Claire Strain-Damerell, J. Houston, P. Nicklin, 2009, Drug Metabolism and Disposition.

In Vitro and in Silico Tools To Assess Extent of Cellular Uptake and Lysosomal Sequestration of Respiratory Drugs in Human Alveolar Macrophages.

Michael Gertz, Aleksandra Galetin, J Brian Houston, 2017, Molecular pharmaceutics.

Cyclosporine Inhibition of Hepatic and Intestinal CYP3A4, Uptake and Efflux Transporters: Application of PBPK Modeling in the Assessment of Drug-Drug Interaction Potential

Malcolm Rowland, Michael Gertz, Aleksandra Galetin, 2012, Pharmaceutical Research.

Mechanistic Pharmacokinetic Modeling for the Prediction of Transporter-Mediated Disposition in Humans from Sandwich Culture Human Hepatocyte Data

Hugh A. Barton, Aleksandra Galetin, Yurong Lai, 2012, Drug Metabolism and Disposition.

Saturable Uptake of Lipophilic Amine Drugs into Isolated Hepatocytes: Mechanisms and Consequences for Quantitative Clearance Prediction

J Brian Houston, J. Houston, D. Hallifax, 2007, Drug Metabolism and Disposition.

Uptake and Intracellular Binding of Lipophilic Amine Drugs by Isolated Rat Hepatocytes and Implications for Prediction of in Vivo Metabolic Clearance

J. Houston, D. Hallifax, David Hallifax, 2006, Drug Metabolism and Disposition.

Sigmoidal Kinetics of CYP 3 A Substrates : An Approach for Scaling Dextromethorphan Metabolism in Hepatic Microsomes and Isolated Hepatocytes to Predict In Vivo Clearance in Rat 1

J. Houston, L. E. Witherow, 1999 .

Antinuclear factor in rapid and slow acetylator patients treated with isoniazid.

C. A. Hopkins, J. Houston, D. Evans, 1972, Journal of medical genetics.

Antinuclear Factor inRapid andSlowAcetylator Patients Treated withIsoniazid

C. A. Hopkins, J. Houston, M. Bullen, 1972 .

Modelling atypical CYP3A4 kinetics: principles and pragmatism.

Aleksandra Galetin, J Brian Houston, A. Galetin, 2005, Archives of biochemistry and biophysics.

Prediction of metabolic clearance using fresh human hepatocytes: Comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines

A. Galetin, J. Houston, D. Hallifax, 2008, Xenobiotica; the fate of foreign compounds in biological systems.

Comparative Analysis of CYP3A Heteroactivation by Steroid Hormones and Flavonoids in Different in Vitro Systems and Potential in Vivo Implications

A. Galetin, J. Houston, A. Harrison, 2008, Drug Metabolism and Disposition.

CYP 3 A 4 Substrate Selection and Substitution in the Prediction of Potential Drug-Drug Interactions

Kiyomi Ito, A. Galetin, J. Houston, 2005 .

vitro clearance and permeability data

A. Galetin, J. Houston, Michael Gertz, 2010 .

P450 and UGT cofactors in alamethicin activated human liver microsomes

A. Galetin, J. Houston, P. Kilford, 2008 .

DRUG-DRUG INTERACTIONS : CYP 2 D 6 PARADIGM

Kiyomi Ito, J. Houston, D. Hallifax, 2005 .

Influence of phenobarbitone pretreatment on disposition of amidopyrine and its metabolites in rat

J. Houston, G. Lockwood, 1980, The Journal of pharmacy and pharmacology.

Sigmoidal kinetics of CYP3A substrates: an approach for scaling dextromethorphan metabolism in hepatic microsomes and isolated hepatocytes to predict in vivo clearance in rat.

J. Houston, L. E. Witherow, 1999, The Journal of pharmacology and experimental therapeutics.

Effect of Omeprazole on Diazepam Disposition in the Rat: in Vitro and in Vivo Studies

J. Houston, K. Zomorodi, 1995, Pharmaceutical Research.

JPET #93229 1 THE UTILITY OF IN VITRO CYTOCHROME P450 INHIBITION DATA IN THE PREDICTION OF DRUG-DRUG INTERACTIONS

J. Houston, R. Walsky, K. Venkatakrishnan, 2005 .

The Prediction of Systemic Toxicity by Integrating the Results of Biokinetic Models and Biologically Based In Vitro Test Methods

J. DeJongh, J. Houston, A. Guillouzo, 2002 .

Intestinal and Hepatic Metabolic Activity of Five Cytochrome P450 Enzymes: Impact on Prediction of First-Pass Metabolism

A. Galetin, J. Houston, B. Houston, 2006, Journal of Pharmacology and Experimental Therapeutics.

In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383

A. Galetin, J. Houston, Ayşe Ufuk, 2015, Pharmaceutical Research.

Use of Segregated Hepatocyte Scaling Factors and Cross-Species Relationships to Resolve Clearance Dependence in the Prediction of Human Hepatic Clearance

J. Houston, D. Hallifax, 2019, Drug Metabolism and Disposition.

Metabolite Formation Kinetics and Intrinsic Clearance of Phenacetin, Tolbutamide, Alprazolam, and Midazolam in Adenoviral Cytochrome P450-Transfected HepG2 Cells and Comparison with Hepatocytes and In Vivo

J. Houston, D. Hallifax, M. T. Donato, 2010, Drug Metabolism and Disposition.

Prediction of in vivo disposition from in vitro systems: clearance of phenytoin and tolbutamide using rat hepatic microsomal and hepatocyte data.

J. Houston, D. Carlile, R. Chenery, 1995, The Journal of pharmacology and experimental therapeutics.

A Comprehensive Assessment of Repaglinide Metabolic Pathways: Impact of Choice of In Vitro System and Relative Enzyme Contribution to In Vitro Clearance

A. Galetin, J. Houston, C. Säll, 2012, Drug Metabolism and Disposition.

Hepatic Organic Anion Transporting Polypeptide–Mediated Clearance in the Beagle Dog: Assessing In Vitro–In Vivo Relationships and Applying Cross-Species Empirical Scaling Factors to Improve Prediction of Human Clearance

K. Hillgren, A. Galetin, J. Houston, 2018, Drug Metabolism and Disposition.

In vivo assessment of extrahepatic conjugative metabolism in first pass effects using the model compound phenol

J. Houston, M. Cassidy, 1980, The Journal of pharmacy and pharmacology.

Importance of the Unstirred Water Layer and Hepatocyte Membrane Integrity In Vitro for Quantification of Intrinsic Metabolic Clearance

J. Houston, D. Hallifax, F. Wood, 2018, Drug Metabolism and Disposition.

Evaluation of the novel in vitro systems for hepatic drug clearance and assessment of their predictive utility.

J. Houston, K. Rowland-Yeo, U. Zanelli, 2012, Toxicology in vitro : an international journal published in association with BIBRA.

Reliability of human cryopreserved hepatocytes and liver microsomes as in vitro systems to predict metabolic clearance

J. Houston, P. Nicklin, R. Stringer, 2008 .

Impact of Plasma Protein Binding in Drug Clearance Prediction: A Database Analysis of Published Studies and Implications for In Vitro-In Vivo Extrapolation

J. Houston, D. Hallifax, L. Francis, 2020, Drug Metabolism and Disposition.

Reliability of human cryopreserved hepatocytes and liver microsomes as in vitro systems to predict metabolic clearance.

J. Houston, P. Nicklin, R. Stringer, 2008, Xenobiotica; the fate of foreign compounds in biological systems.

Kinetics of drug metabolism inhibition: Use of metabolite concentration-time profiles

J. Houston, P. N. Shaw, 1987, Journal of Pharmacokinetics and Biopharmaceutics.

Metabolism of theophylline and its inhibition by fluoroquinolones in rat hepatic microsomes.

L. Aarons, J. Houston, J. Davis, 1995, Xenobiotica; the fate of foreign compounds in biological systems.

Drug metabolizing capacity in vitro and in vivo--I. Correlations between hepatic microsomal monooxygenase markers in beta-naphthoflavone-induced rats.

J. Houston, D. Matthew, 1990, Biochemical pharmacology.

Effect of promethazine and isosafrole on rat-hepatic microsomal mono-oxygenase activity: comparison with classic inducers phenobarbitone and beta-naphthoflavone.

J. Houston, C. Elcombe, G. Taylor, 1985, Xenobiotica; the fate of foreign compounds in biological systems.

Comparison of two azole antifungal drugs, ketoconazole, and fluconazole, as modifiers of rat hepatic monooxygenase activity.

J. Houston, M. Tarbit, M. Humphrey, 1988, Biochemical pharmacology.

In vivo disposition of caffeine predicted from hepatic microsomal and hepatocyte data.

J. Houston, R. Chenery, B. Brennan, 1995, Drug metabolism and disposition: the biological fate of chemicals.

Defining the in Vivo Role for Cytochrome b5 in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b5*S⃞

R. Finn, J. Houston, C. Wolf, 2008, Journal of Biological Chemistry.

Induction of cytochromes P-450 in pancreatic disease: consequence, coincidence or cause?

J. Houston, D. Acheson, J. Braganza, 1985, Clinica chimica acta; international journal of clinical chemistry.

Determinants of systemic availability of promethazine in rabbits

J. Houston, G. Taylor, 1983, The Journal of pharmacy and pharmacology.

Multisite kinetic models for CYP3A4: simultaneous activation and inhibition of diazepam and testosterone metabolism.

J. Houston, S. Clarke, Kathryn E. Kenworthy, 2001, Drug metabolism and disposition: the biological fate of chemicals.

DMD050294 744..753

A. Galetin, J. Houston, Katherine L. Gill, 2013 .

Quantitation of extrahepatic metabolism. Pulmonary and intestinal conjugation of naphthol.

J. Houston, M. Mistry, 1985, Drug metabolism and disposition: the biological fate of chemicals.

In vivo capacity of hepatic and extrahepatic enzymes to conjugate phenol.

J. Houston, M. Cassidy, 1984, Drug metabolism and disposition: the biological fate of chemicals.

Selectivity of omeprazole inhibition towards rat liver cytochromes P450.

J. Houston, K. Zomorodi, 1997, Xenobiotica; the fate of foreign compounds in biological systems.

Diazepam-omeprazole inhibition interaction: an in vitro investigation using human liver microsomes.

J. Houston, K. Zomorodi, 1996, British journal of clinical pharmacology.

Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: utility and limitations.

John D. Davis, A. Galetin, J. Houston, 2008, Current drug metabolism.

Kinetics of metabolism of deltamethrin and cis- and trans-permethrin in vitro. Studies using rat and human liver microsomes, isolated rat hepatocytes and rat liver cytosol

J. Houston, R. J. Price, B. Lake, 2020, Xenobiotica; the fate of foreign compounds in biological systems.

Phenol conjugation by lung in vivo.

J. Houston, M. Cassidy, 1980, Biochemical pharmacology.

Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs.

J. Houston, D. Hallifax, E. Turlizzi, 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Time-Dependent Disposition of β-Naphthoflavone in the Rat

L. Aarons, J. Houston, A. Adedoyin, 2004, Pharmaceutical Research.

Pharmacokinetics of promethazine and its sulphoxide metabolite after intravenous and oral administration to man.

J. Houston, G. Mawer, J. Shaffer, 1983, British journal of clinical pharmacology.

Theophylline and antipyrine disposition in smoking and non-smoking epileptic subjects.

J. Houston, D. Acheson, S. Uden, 1987, British journal of clinical pharmacology.

The Use of Biokinetics and in Vitro Methods in Toxicological Risk Evaluation

Gunnar Johanson, John M. Frazier, Christoph A. Reinhardt, 1996 .

Prediction of In Vivo Drug-Drug Interactions from In Vitro Data

Aleksandra Galetin, J Brian Houston, Hayley S. Brown, 2006, Clinical pharmacokinetics.

Drug metabolite kinetics.

J. Houston, J. Houston, 1981, Pharmacology & therapeutics.

Microsomal prediction of in vivo clearance and associated interindividual variability of six benzodiazepines in humans

J B Houston, A. Galetin, J. Houston, 2005, Xenobiotica; the fate of foreign compounds in biological systems.

In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises.

J Brian Houston, J. Houston, K. Knights, 2006, Biochemical pharmacology.

Disposition of Azole Antifungal Agents. I. Nonlinearities in Ketoconazole Clearance and Binding in Rat Liver

J. Houston, K. Zomorodi, B. Brennan, 1993, Pharmaceutical Research.

Reduced Physiologically-Based Pharmacokinetic Model of Repaglinide: Impact of OATP1B1 and CYP2C8 Genotype and Source of In Vitro Data on the Prediction of Drug-Drug Interaction Risk

A. Galetin, J. Houston, N. Tsamandouras, 2014, Pharmaceutical Research.

Assessment of algorithms for predicting drug-drug interactions via inhibition mechanisms: comparison of dynamic and static models.

Amin Rostami-Hodjegan, Aleksandra Galetin, Eleanor J Guest, 2009, British journal of clinical pharmacology.

Contribution of intestinal cytochrome p450-mediated metabolism to drug-drug inhibition and induction interactions.

A. Galetin, J. Houston, Michael Gertz, 2010, Drug metabolism and pharmacokinetics.

Clearance Prediction Methodology Needs Fundamental Improvement: Trends Common to Rat and Human Hepatocytes/Microsomes and Implications for Experimental Methodology

J B Houston, J. Houston, D. Hallifax, 2017, Drug Metabolism and Disposition.

Comparison of ketoconazole and fluconazole as cytochrome P450 inhibitors. Use of steady-state infusion approach to achieve plasma concentration-response relationships.

J. Houston, B. Brennan, D. Matthew, 1996, Drug metabolism and disposition: the biological fate of chemicals.

Disposition of Azole Antifimgal Agents. III. Binding of Fluconazole and Other Azoles in Rat Liver

J. Houston, C. M. Ervine, 1994, Pharmaceutical Research.

Disposition of Azole Antifungal Agents. II. Hepatic Binding and Clearance of Dichlorophenyl-Bis-triazolylpropanol (DTP) in the Rat

J. Houston, M. Tarbit, M. Humphrey, 1994, Pharmaceutical Research.

Amidopyrine disposition in rat

J. Houston, G. Lockwood, 1979, The Journal of pharmacy and pharmacology.

Use of Isolated Hepatocyte Preparations for Cytochrome P450 Inhibition Studies: Comparison with Microsomes for Ki Determination

Hayley S. Brown, J. Houston, A. Chadwick, 2007, Drug Metabolism and Disposition.

IMPACT OF PARALLEL PATHWAYS OF DRUG ELIMINATION AND MULTIPLE CYTOCHROME P450 INVOLVEMENT ON DRUG-DRUG INTERACTIONS: CYP2D6 PARADIGM

Kiyomi Ito, J Brian Houston, Kiyomi Ito, 2005, Drug Metabolism and Disposition.

Database analyses for the prediction of in vivo drug-drug interactions from in vitro data.

Kiyomi Ito, J Brian Houston, Hayley S. Brown, 2004, British journal of clinical pharmacology.

Experimental determination of a drug targeting index for S(+)ibuprofen using the rat air pouch model of inflammation.

J. Houston, B. Brennan, M. Rowland, 1994, Journal of drug targeting.

The metabolism of the 5HT3 antagonists, ondansetron, alosetron and GR87442 II: Investigation into the in vitro methods used to predict the in vivo hepatic clearance of ondansetron, alosetron and GR87442 in the rat, dog and human

J. Houston, M. Bayliss, G. Somers, 2007, Xenobiotica; the fate of foreign compounds in biological systems.

The metabolism of the 5HT3 antagonists ondansetron, alosetron and GR87442 I: A comparison of in vitro and in vivo metabolism and in vitro enzyme kinetics in rat, dog and human hepatocytes, microsomes and recombinant human enzymes

J. Houston, M. Bayliss, G. Somers, 2007, Xenobiotica; the fate of foreign compounds in biological systems.

Simultaneous assay of fluoroquinolones and theophylline in plasma by high-performance liquid chromatography.

L. Aarons, J. Houston, J. Davis, 1993, Journal of chromatography.

In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model.

J B Houston, J. Houston, Kathryn E. Kenworthy, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: studies with induced livers involving diazepam.

J B Houston, J. Houston, K. Zomorodi, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Saliva: plasma concentration relationships for sulphapyridine following sulphasalazine administration to normal volunteers and patients with inflammatory bowel disease.

J. Houston, J. Day, 1980, British journal of clinical pharmacology.

Progress Curve Mechanistic Modeling Approach for Assessing Time-Dependent Inhibition of CYP3A4

A. Galetin, J. Houston, H. Pertinez, 2012, Drug Metabolism and Disposition.

Use of Mechanistic Modeling to Assess Interindividual Variability and Interspecies Differences in Active Uptake in Human and Rat Hepatocytes

Aleksandra Galetin, J Brian Houston, A. Galetin, 2012, Drug Metabolism and Disposition.

Simultaneous determination of promethazine and two of its circulating metabolites by high-performance liquid chromatography.

J. Houston, G. Taylor, 1982, Journal of chromatography.

Hepatocellular Binding of Drugs: Correction for Unbound Fraction in Hepatocyte Incubations Using Microsomal Binding or Drug Lipophilicity Data

Michael Gertz, Aleksandra Galetin, J Brian Houston, 2008, Drug Metabolism and Disposition.

Determination of a Human Hepatic Microsomal Scaling Factor for Predicting in Vivo Drug Clearance

Kiyomi Ito, J. Houston, R. Edwards, 2006, Pharmaceutical Research.

Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices.

J B Houston, J. Houston, D. Carlile, 1997, Drug metabolism reviews.

Prediction of Human Drug Clearance by Multiple Metabolic Pathways: Integration of Hepatic and Intestinal Microsomal and Cytosolic Data

Aleksandra Galetin, A. Galetin, J. Houston, 2011, Drug Metabolism and Disposition.

Prediction of Human Drug Clearance by Multiple Metabolic Pathways: Integration of Hepatic and Intestinal Microsomal and Cytosolic Data

A. Galetin, J. Houston, H. Cubitt, 2011, Drug Metabolism And Disposition.

Evaluation of Cryopreserved Human Hepatocytes as an Alternative in Vitro System to Microsomes for the Prediction of Metabolic Clearance

J Brian Houston, Hayley S. Brown, J. Houston, 2007, Drug Metabolism and Disposition.

Absorption of prednisolone in patients with Crohn's disease.

J. Houston, M. Rowland, S. E. Williams, 1983, Gut.

Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition.

Li Di, Manfred Kansy, Kiyohiko Sugano, 2014, Molecular pharmaceutics.

IC50-based approaches as an alternative method for assessment of time-dependent inhibition of CYP3A4

A. Galetin, J. Houston, H. Burt, 2010, Xenobiotica; the fate of foreign compounds in biological systems.

Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: midazolam, testosterone, and nifedipine.

A. Galetin, J. Houston, S. Clarke, 2003, Drug metabolism and disposition: the biological fate of chemicals.

CYP3A4 drug interactions: correlation of 10 in vitro probe substrates.

J B Houston, J. Houston, J. Bloomer, 1999, British journal of clinical pharmacology.

Glucuronidation in vitro and in vivo. Comparison of intestinal and hepatic conjugation of morphine, naloxone, and buprenorphine.

J. Houston, M. Mistry, 1987, Drug metabolism and disposition: the biological fate of chemicals.

Hepatic, Intestinal, Renal, and Plasma Hydrolysis of Prodrugs in Human, Cynomolgus Monkey, Dog, and Rat: Implications for In Vitro–In Vivo Extrapolation of Clearance of Prodrugs

Aleksandra Galetin, J Brian Houston, A. Galetin, 2014, Drug Metabolism and Disposition.

Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data

Michael Gertz, Aleksandra Galetin, J Brian Houston, 2013, Drug Metabolism and Disposition.

Prediction of Human Intestinal First-Pass Metabolism of 25 CYP3A Substrates from In Vitro Clearance and Permeability Data

Michael Gertz, Aleksandra Galetin, J Brian Houston, 2010, Drug Metabolism and Disposition.

Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes

Aleksandra Galetin, A. Galetin, J. Houston, 2009, Drug Metabolism and Disposition.

Relative Importance of Intestinal and Hepatic Glucuronidation—Impact on the Prediction of Drug Clearance

A. Galetin, J. Houston, H. Cubitt, 2009, Pharmaceutical Research.

Potential role of intestinal first-pass metabolism in the prediction of drug–drug interactions

A. Galetin, J. Houston, Michael Gertz, 2008, Expert opinion on drug metabolism & toxicology.

Drug Lipophilicity and Microsomal Protein Concentration as Determinants in the Prediction of the Fraction Unbound in Microsomal Incubations

A. Galetin, J. Houston, Michael Gertz, 2008, Drug Metabolism and Disposition.

Multiple Inhibition Mechanisms and Prediction of Drug–Drug Interactions: Status of Metabolism and Transporter Models as Exemplified by Gemfibrozil–Drug Interactions

Aleksandra Galetin, A. Galetin, J. Houston, 2008, Pharmaceutical Research.

Maximal inhibition of intestinal first-pass metabolism as a pragmatic indicator of intestinal contribution to the drug-drug interactions for CYP3A4 cleared drugs.

Aleksandra Galetin, J Brian Houston, A. Galetin, 2007, Current drug metabolism.

BINDING OF DRUGS TO HEPATIC MICROSOMES: COMMENT AND ASSESSMENT OF CURRENT PREDICTION METHODOLOGY WITH RECOMMENDATION FOR IMPROVEMENT

J Brian Houston, J. Houston, D. Hallifax, 2006, Drug Metabolism and Disposition.

Prediction of Human Drug Clearance from in Vitro and Preclinical Data Using Physiologically Based and Empirical Approaches

Kiyomi Ito, Kiyomi Ito, J. Houston, 2004, Pharmaceutical Research.

Effect of vitamin C supplement on antipyrine disposition in man.

J. Houston, 1977, British journal of clinical pharmacology.

Human udp-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid.

A. Galetin, J. Houston, J. Miners, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Comparison of the Use of Liver Models for Predicting Drug Clearance Using in Vitro Kinetic Data from Hepatic Microsomes and Isolated Hepatocytes

Kiyomi Ito, Kiyomi Ito, J. Houston, 2004, Pharmaceutical Research.

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance.

J B Houston, J. Houston, 1994, Biochemical pharmacology.

Disposition of metronidazole and its effects on sulphasalazine metabolism in patients with inflammatory bowel disease.

J. Houston, A. Kershaw, J. Shaffer, 1986, British journal of clinical pharmacology.

Adam S. Hayward, C. Meyer, S. Dooley, 2013, Archives of Toxicology.

Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans.

J. Houston, N. Hakooz, M. Bayliss, 1999, British journal of clinical pharmacology.

The six-day-old rat air pouch model of inflammation: characterization of the inflammatory response to carrageenan.

J. Houston, M. Rowland, B. Brennan, 1994, Journal of pharmacological and toxicological methods.

Effect of Norfloxacin on Theophylline Disposition: A Comparison with Other Fluoroquinolones

John D. Davis, L. Aarons, J. Houston, 1995, Pharmaceutical Research.

The Critical Role of Passive Permeability in Designing Successful Drugs

L. Benet, M. Kansy, J. Houston, 2020, ChemMedChem.

Assessment of intestinal permeability changes induced by nonsteroidal anti-inflammatory drugs in the rat.

J. Houston, J. Ford, S. W. Martin, 1995, Journal of pharmacological and toxicological methods.

Antipyrine metabolite kinetics in healthy human volunteers during multiple dosing of phenytoin and carbamazepine.

J. Houston, P. N. Shaw, P. Morselli, 1985, British journal of clinical pharmacology.

Effect of pregnenolone carbonitrile, promethazine and antipyrine pretreatment on antipyrine metabolite formation in rats.

J. Houston, P. N. Shaw, S. Hall, 1986, Xenobiotica; the fate of foreign compounds in biological systems.

Antipyrine metabolite kinetics in phenobarbital and beta-naphthoflavone-induced rats.

J. Houston, J. Rhodes, 1983, Drug Metabolism And Disposition.

Quantification of Metabolites of Aminopyrine and Antipyrine in Plasma and Urine

J. Houston, J. Rhodes, 1983 .

Drug metabolite concentration-time profiles: influence of route of drug administration.

J. Houston, G. Taylor, 1984, British journal of clinical pharmacology.

Characterization of In Vitro Glucuronidation Clearance of a Range of Drugs in Human Kidney Microsomes: Comparison with Liver and Intestinal Glucuronidation and Impact of Albumin

A. Galetin, J. Houston, Katherine L. Gill, 2012, Drug Metabolism and Disposition.

Changes in the disposition of promethazine during multiple dosing in the rabbit

J. Houston, G. Taylor, 1985, The Journal of pharmacy and pharmacology.

Aminopyrine demethylation kinetics. Use of metabolite exhalation rates as an index of enhanced mixed-function oxidase activity in vivo.

J. Houston, G. Lockwood, G. Taylor, 1981, Drug metabolism and disposition: the biological fate of chemicals.

Inhibition of antipyrine metabolite formation in rats in vivo.

J. Houston, S. Hall, J. Rhodes, 1984, Xenobiotica; the fate of foreign compounds in biological systems.

Antipyrine metabolite kinetics in rats: studies on dose and time dependence.

J. Houston, J. Rhodes, 1983, Biopharmaceutics & drug disposition.

Drug metabolizing capacity in vitro and in vivo--II. Correlations between hepatic microsomal monooxygenase markers in phenobarbital-induced rats.

J. Houston, D. Matthew, 1990, Biochemical pharmacology.

Temporal effects on antipyrine metabolite kinetics in Aroclor 1254-treated rats.

J. Houston, P. N. Shaw, 1986, Toxicology and applied pharmacology.

IN‐VIVO DETERMINATIONS OF THE POTENCY OF KETOCONAZOLE IN INHIBITING DRUG METABOLISM IN THE RAT

H. Humphrey, J. Houston, M. Tarbit, 1986 .

INDUCTION OF DRUG METABOLISING CAPACITY IN THE RAT BY DI‐(2‐ETHYLHEXYL) PHTHALATE

J. Houston, D. Matthew, 1985 .

Factors contributing to the accelerated clearance of theophylline and antipyrine in adults with exocrine pancreatic disease.

J. Houston, L. Hunt, D. Acheson, 1989, Clinical science.

Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach.

A. Galetin, J. Houston, S. Clarke, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Simultaneous Assessment In Vitro of Transporter and Metabolic Processes in Hepatic Drug Clearance: Use of a Media Loss Approach

Adam S Darwich, J Brian Houston, J. Houston, 2018, Drug Metabolism and Disposition.

Rate limiting steps in metabolite kinetics: formation of 5‐acetylaminosalicylate after administration of 5‐aminosalicylate

J. Houston, M. Cassidy, 1982, The Journal of pharmacy and pharmacology.

In vivo clearance of ethoxycoumarin and its prediction from In vitro systems. Use Of drug depletion and metabolite formation methods in hepatic microsomes and isolated hepatocytes.

J. Houston, D. Carlile, A. J. Stevens, 1998, Drug metabolism and disposition: the biological fate of chemicals.

A rapid method for the simultaneous determination of the major metabolites of sulphasalazine in plasma.

L. Aarons, J. Houston, P. N. Shaw, 1983, Journal of chromatography.

HPLC ANALYSIS OF SULPHASALAZINE AND ITS METABOLITES

L. Aarons, J. Houston, P. N. Shaw, 1980 .

Evaluation of hepatic clearance prediction using in vitro data: emphasis on fraction unbound in plasma and drug ionisation using a database of 107 drugs.

J. Houston, D. Hallifax, 2012, Journal of pharmaceutical sciences.

In vitro human tissue models in risk assessment: report of a consensus-building workshop.

J B Houston, G. L. Kedderis, K Krishnan, 2001, Toxicological sciences : an official journal of the Society of Toxicology.

Regional Drug Delivery I: Permeability Characteristics of the Rat 6-Day-Old Air Pouch Model of Inflammation

Steven W. Martin, J. Houston, B. Brennan, 1995, Pharmaceutical Research.

Pharmacodynamic Comparison of Regional Drug Delivery for Non‐steroidal Anti‐inflammatory Drugs, Using the Rat Air‐pouch Model of Inflammation

J. Houston, B. Brennan, M. Rowland, 1995, The Journal of pharmacy and pharmacology.

Impact of end-product inhibition on the determination of in vitro metabolic clearance

J. Houston, H. Jones, G. Nicholls, 2005, Xenobiotica; the fate of foreign compounds in biological systems.

SUBSTRATE DEPLETION APPROACH FOR DETERMINING IN VITRO METABOLIC CLEARANCE: TIME DEPENDENCIES IN HEPATOCYTE AND MICROSOMAL INCUBATIONS

Hannah M Jones, J Brian Houston, J. Houston, 2004, Drug Metabolism and Disposition.

Rate-Limiting Steps in Hepatic Drug Clearance: Comparison of Hepatocellular Uptake and Metabolism with Microsomal Metabolism of Saquinavir, Nelfinavir, and Ritonavir

J. Houston, J. Brian Houston, Alison J. Parker, 2008, Drug Metabolism and Disposition.

Quantitative prediction of the in vivo inhibition of diazepam metabolism by omeprazole using rat liver microsomes and hepatocytes.

J. Houston, D. Hallifax, H. Jones, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Typical and Atypical Enzyme Kinetics

A. Galetin, J. Houston, Kathryn E. Kenworthy, 2003 .

Kinetics of diazepam metabolism in rat hepatic microsomes and hepatocytes and their use in predicting in vivo hepatic clearance.

J. Houston, K. Zomorodi, D. Carlile, 1995, Xenobiotica; the fate of foreign compounds in biological systems.

High-performance liquid chromatographic method for the simultaneous determination of cimetidine and antipyrine in plasma.

L. Aarons, J. Houston, A. Adedoyin, 1985, Journal of Chromatography A.

Dose-dependent pharmacokinetics of cimetidine in the rat.

L. Aarons, J. Houston, A. Adedoyin, 1987, Xenobiotica; the fate of foreign compounds in biological systems.

PLASMA CONCENTRATION‐RESPONSE RELATIONSHIP FOR CIMETIDINE INHIBITION OF DRUG METABOLISM IN THE RAT

L. Aarons, J. Houston, A. Adedoyin, 1985, Drug metabolism and disposition: the biological fate of chemicals.

Determination of Promethazine in Biological Fluids

J. Houston, R. Calvert, G. Taylor, 1979 .

Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human udp-glucuronosyltransferases: evidence for atypical glucuronidation kinetics by UGT2B7.

A. Galetin, J. Houston, J. Miners, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Interpretation of CO2 exhalation rate data from demethylation of aminopyrine and its metabolite monomethylaminoantipyrine.

L. Aarons, J. Houston, J. Rhodes, 1982, British journal of clinical pharmacology.

Azo reduction of sulphasalazine in healthy volunteers.

J. Houston, J. Day, J. Walker, 1982, British journal of clinical pharmacology.

The effect of rifampicin on sulphapyridine plasma concentrations following sulphasalazine administration.

J. Houston, J. Shaffer, 1985, British journal of clinical pharmacology.

PREDICTION OF TIME-DEPENDENT CYP3A4 DRUG-DRUG INTERACTIONS: IMPACT OF ENZYME DEGRADATION, PARALLEL ELIMINATION PATHWAYS, AND INTESTINAL INHIBITION

Aleksandra Galetin, J Brian Houston, A. Galetin, 2006, Drug Metabolism and Disposition.

Predictive Models of CYP3A4 Heteroactivation: In Vitro-in Vivo Scaling and Pharmacophore Modeling

Ann-Charlotte Egnell, J Brian Houston, J. Houston, 2005, Journal of Pharmacology and Experimental Therapeutics.

An Integrated Approach to the Prediction of Systemic Toxicity using Computer-based Biokinetic Models and Biological In vitro Test Methods: Overview of a Prevalidation Study Based on the ECITTS Project.

J B Houston, B J Blaauboer, J. DeJongh, 1999, Toxicology in vitro : an international journal published in association with BIBRA.

Reduced Physiologically-Based Pharmacokinetic Model of Repaglinide: Impact of OATP1B1 and CYP2C8 Genotype and Source of In Vitro Data on the Prediction of Drug-Drug Interaction Risk

Nikolaos Tsamandouras, Michael Gertz, Aleksandra Galetin, 2014, Pharmaceutical Research.

EFFECT OF STRUCTURAL MODIFICATIONS ON DRUG‐HEPATIC MICROSOMAL INTERACTIONS

J. Houston, J. Bridges, K. Al-Gailany, 1977, The Journal of pharmacy and pharmacology.

Comparative Use of Isolated Hepatocytes and Hepatic Microsomes for Cytochrome P450 Inhibition Studies: Transporter-Enzyme Interplay

Hayley S. Brown, J. Houston, M. Ohta, 2010, Drug Metabolism and Disposition.

Use of Isolated Hepatocyte Preparations for Cytochrome P450 Inhibition Studies: Comparison with Microsomes for Ki Determination

Hayley S. Brown, J. Houston, B. Houston, 2007, Drug Metabolism and Disposition.

Simultaneous Assessment of Uptake and Metabolism in Rat Hepatocytes: A Comprehensive Mechanistic Model

Aleksandra Galetin, A. Galetin, J. Houston, 2012, Journal of Pharmacology and Experimental Therapeutics.

Cyclosporine Inhibition of Hepatic and Intestinal CYP3A4, Uptake and Efflux Transporters: Application of PBPK Modeling in the Assessment of Drug-Drug Interaction Potential

A. Galetin, J. Houston, M. Rowland, 2013, Pharmaceutical Research.

Utility of Drug Depletion-Time Profiles in Isolated Hepatocytes for Accessing Hepatic Uptake Clearance: Identifying Rate-Limiting Steps and Role of Passive Processes

J. Houston, Emilie Jigorel, Brian Houston, 2012, Drug Metabolism and Disposition.

Critique of the Two-Fold Measure of Prediction Success for Ratios: Application for the Assessment of Drug-Drug Interactions

L. Aarons, A. Galetin, J. Houston, 2011, Drug Metabolism and Disposition.

UTILITY OF RECOMBINANT ENZYME KINETICS IN PREDICTION OF HUMAN CLEARANCE: IMPACT OF VARIABILITY, CYP3A5, AND CYP2C19 ON CYP3A4 PROBE SUBSTRATES

Aleksandra Galetin, Kiyomi Ito, J Brian Houston, 2004, Drug Metabolism and Disposition.

Prediction of Human Metabolic Clearance from In Vitro Systems: Retrospective Analysis and Prospective View

J. Houston, D. Hallifax, David Hallifax, 2010, Pharmaceutical Research.

Prediction of Human Pharmacokinetics in 2013 and Beyond

J Brian Houston, J. Houston, 2013, Drug Metabolism and Disposition.

The Integrated Use of Alternative Methods in Toxicological Risk Evaluation

J B Houston, M D Barratt, B J Blaauboer, 1999, Alternatives to laboratory animals : ATLA.

Kinetic Modeling of the Interactions between 4-Methylumbelliferone, 1-Naphthol, and Zidovudine Glucuronidation by UDP-Glucuronosyltransferase 2B7 (UGT2B7) Provides Evidence for Multiple Substrate Binding and Effector Sites

A. Galetin, J. Houston, J. Miners, 2008, Molecular Pharmacology.

Effects of cold stress and ether stress on aminopyrine demethylation kinetics in vivo

J. Houston, G. F. Lockwood, G. Lockwood, 1982 .

Inhibition of antipyrine metabolite formation. Steady state studies with cimetidine and metyrapone in rats.

J. Houston, P. N. Shaw, A. Adedoyin, 1986, Drug Metabolism And Disposition.

Comparison of intrinsic clearances in human liver microsomes and suspended hepatocytes from the same donor livers: clearance-dependent relationship and implications for prediction of in vivo clearance

J. Houston, D. Hallifax, Joanne A. Foster, 2011, Xenobiotica; the fate of foreign compounds in biological systems.

Comparison of Cryopreserved HepaRG Cells with Cryopreserved Human Hepatocytes for Prediction of Clearance for 26 Drugs

Ugo Zanelli, J. Houston, D. Hallifax, 2012, Drug Metabolism and Disposition.

Methodological uncertainty in quantitative prediction of human hepatic clearance from in vitro experimental systems.

J B Houston, J. Houston, D. Hallifax, 2009, Current drug metabolism.

Understanding the Interplay Between Uptake and Efflux Transporters Within In Vitro Systems in Defining Hepatocellular Drug Concentrations.

J. Houston, Carina Cantrill, 2017, Journal of pharmaceutical sciences.

Kinetic Characterization of Rat Hepatic Uptake of 16 Actively Transported Drugs

Aleksandra Galetin, J Brian Houston, A. Galetin, 2011, Drug Metabolism and Disposition.

Microsoft Word-14766297-file00

A. Galetin, J. Houston, Y. Yabe, 2011 .

PREDICTION OF METABOLIC CLEARANCE USING CRYOPRESERVED HUMAN HEPATOCYTES: KINETIC CHARACTERISTICS FOR FIVE BENZODIAZEPINES

J. Houston, D. Hallifax, N. Hakooz, 2005, Drug Metabolism and Disposition.

Prediction of in vitro intrinsic clearance from hepatocytes: comparison of suspensions and monolayer cultures.

J Brian Houston, J. Houston, Sarah J Griffin, 2005, Drug metabolism and disposition: the biological fate of chemicals.

Pharmacokinetics in Early Drug Research

J B Houston, D A Smith, J H Fentem, 1997, Alternatives to laboratory animals : ATLA.

Methods for predicting in vivo pharmacokinetics using data from in vitro assays.

Aleksandra Galetin, J Brian Houston, A. Galetin, 2008, Current drug metabolism.

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport.

G. Ecker, M. Kansy, J. Houston, 2012, Drug discovery today.

In Vitro–In Vivo Extrapolation of OATP1B-Mediated Drug–Drug Interactions in Cynomolgus Monkey

A. D. Rodrigues, A. Galetin, J. Houston, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Methodology for development of a physiological model incorporating CYP3A and P-glycoprotein for the prediction of intestinal drug absorption.

A. Galetin, J. Houston, R. Badhan, 2009, Journal of pharmaceutical sciences.

UTILITY OF RECOMBINANT ENZYME KINETICS IN PREDICTION OF HUMAN CLEARANCE : IMPACT OF VARIABILITY , CYP 3 A 5 , AND CYP 2 C 19 ON CYP 3 A 4 PROBE SUBSTRATES

Kiyomi Ito, A. Galetin, J. Houston, 2004 .

Potential role of intestinal first-pass metabolism in the prediction of drug-drug interactions.

Michael Gertz, Aleksandra Galetin, J Brian Houston, 2008, Expert opinion on drug metabolism & toxicology.

Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells

J B Houston, J. Houston, N. Randolph, 2002, Xenobiotica; the fate of foreign compounds in biological systems.

Incorporation of in vitro drug metabolism data into physiologically-based pharmacokinetic models.

J. Houston, D. Carlile, 1997, Toxicology in vitro : an international journal published in association with BIBRA.

Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance

A. D. Rodrigues, A. David Rodrigues, Manthena V. S. Varma, 2018, Drug Metabolism and Disposition.

In vitro techniques to study drug-drug interactions of drug metabolism: Cytochrome P450

A. Galetin, J. Houston, 2010 .

Influence of Slice Thickness and Culture Conditions on the Metabolism of 7-Ethoxycoumarin in Precision-cut Rat Liver Slices

J. Houston, R. J. Price, A. Renwick, 1998, Alternatives to laboratory animals : ATLA.

Kinetics of drug metabolism in rat liver slices. Rates of oxidation of ethoxycoumarin and tolbutamide, examples of high- and low-clearance compounds.

J. Houston, P. Worboys, A. Bradbury, 1995, Drug metabolism and disposition: the biological fate of chemicals.

Kinetics of drug metabolism in rat liver slices. III. Relationship between metabolic clearance and slice uptake rate.

J. Houston, P. Worboys, A. Bradbury, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Metabolite kinetics of ondansetron in rat. Comparison of hepatic microsomes, isolated hepatocytes and liver slices, with in vivo disposition.

J. Houston, P. Worboys, A. Bradbury, 1996, Xenobiotica; the fate of foreign compounds in biological systems.

Kinetics of drug metabolism in rat liver slices. II. Comparison of clearance by liver slices and freshly isolated hepatocytes.

J. Houston, P. Worboys, A. Bradbury, 1996, Drug metabolism and disposition: the biological fate of chemicals.

In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383

A. Galetin, J. Houston, Ayşe Ufuk, 2015, Pharmaceutical Research.

The Validation of Computational Prediction Techniques

A P Worth, J B Houston, M D Barratt, 1998, Alternatives to laboratory animals : ATLA.

Predictive Utility of In Vitro Rifampin Induction Data Generated in Fresh and Cryopreserved Human Hepatocytes, Fa2N-4, and HepaRG Cells

A. Galetin, J. Houston, I. Templeton, 2011, Drug Metabolism and Disposition.

Kinetics of drug metabolism in rat liver slices: IV. Comparison of ethoxycoumarin clearance by liver slices, isolated hepatocytes, and hepatic microsomes from rats pretreated with known modifiers of cytochrome P-450 activity.

J B Houston, J. Houston, N. Hakooz, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Quantification of naphthyl conjugates. Comparison of high-performance liquid chromatography and selective enzyme hydrolysis methods.

J. Houston, J. Rhodes, 1981, Xenobiotica; the fate of foreign compounds in biological systems.

Optimizing drug development: Strategies to assess drug metabolism/transporter interaction potential‐toward a consensus

Shiew-Mei Huang, J. Houston, G. Tucker, 2001 .

Hepatic OATP-mediated clearance in the Beagle dog: assessing in vitro-in vivo relationships and applying cross species empirical scaling factors to improve prediction of human clearance

K. Hillgren, A. Galetin, J. Houston, 2018 .

Regional Drug Delivery II: Relationship Between Drug Targeting Index and Pharmacokinetic Parameters for Three Non-Steroidal Anti-Inflammatory Drugs Using the Rat Air Pouch Model of Inflammation

Steven W. Martin, J. Houston, A. McLachlan, 1995, Pharmaceutical Research.

The Report and Recommendations of ECVAM Workshop 22 1,2

J. Houston, D. Leahy, F. Darvas, 1997 .

A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: the TARGET study.

Katherine Payne, David W Ray, Simon C Ramsden, 2011, Pharmacogenomics.

Optimising drug development: Strategies to assess drug metabolism/transporter interaction potential - Towards a consensus

Shiew-Mei Huang, J. Houston, G. Tucker, 2001 .

microsomes: Comparison to liver and intestinal glucuronidation and impact of albumin

A. Galetin, J. Houston, Katherine L. Gill, 2012 .

Kinetic Characterization of Rat Hepatic Uptake of 16 Actively Transported Drugs

A. Galetin, J. Houston, Y. Yabe, 2011, Drug Metabolism and Disposition.

Concentration-response relationships for three nonsteroidal anti-inflammatory drugs in the rat intestine

J. Houston, J. Ford, 1995, Human & experimental toxicology.

Hepatocellular Binding of Drugs: Correction for Unbound Fraction in Hepatocyte Incubations Using Microsomal Binding or Drug Lipophilicity Data

A. Galetin, J. Houston, Michael Gertz, 2008, Drug Metabolism and Disposition.

USE OF ISOLATED HEPATOCYTE PREPARATIONS FOR P 450 INHIBITION STUDIES : COMPARISON WITH MICROSOMES FOR KI DETERMINATION

Hayley S. Brown, J. Houston, A. Chadwick, 2007 .

Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance.

J Brian Houston, J. Houston, Sarah J Griffin, 2004, Drug metabolism and disposition: the biological fate of chemicals.

High-performance liquid chromatographic determination of beta-naphthoflavone in biological fluids.

L. Aarons, J. Houston, A. Adedoyin, 1987, Journal of chromatography.

In Vitro and in Silico Tools To Assess Extent of Cellular Uptake and Lysosomal Sequestration of Respiratory Drugs in Human Alveolar Macrophages.

A. Galetin, J. Houston, Valeriu Damian, 2017, Molecular pharmaceutics.

DETERMINANTS OF SYSTEMIC AVAILABILITY OF MORPHINE AND BUPRENORPHINE IN THE RAT

J. Houston, M. Mistry, 1981 .

Critique of the Two-Fold Measure of Prediction Success for Ratios: Application for the Assessment of Drug-Drug Interactions

L. Aarons, A. Galetin, J. Houston, 2011, Drug Metabolism and Disposition.