D. Schmatz

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A simple recipe for drug interaction networks earns its stars

S. Friend, D. Schmatz, 2006, Nature Genetics.

Hit and lead criteria in drug discovery for infectious diseases of the developing world

D. Schmatz, K. Duncan, K. Katsuno, 2015, Nature Reviews Drug Discovery.

E. Scolnick, A. Woods, D. Zaller, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.

D M Schmatz, M. Bednarek, D. Schmatz, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2.

D. Schmatz, R. Myers, M. Fisher, 2001, Bioorganic & medicinal chemistry letters.

Structure, histone deacetylase, and antiprotozoal activities of apicidins B and C, congeners of apicidin with proline and valine substitutions.

D. Schmatz, J. Liesch, D. Zink, 2001, Organic letters.

Synthesis of side chain modified apicidin derivatives: potent mechanism-based histone deacetylase inhibitors

D. Schmatz, R. Myers, M. Fisher, 2000 .

Design and synthesis of histone deacetylase inhibitors: the development of apicidin transition state analogs

D. Schmatz, R. Myers, M. Fisher, 2000 .

Purification of Eimeria sporozoites by DE-52 anion exchange chromatography.

D. Schmatz, M. S. Crane, P. K. Murray, 1984, The Journal of protozoology.

Eimeria tenella: parasite-specific incorporation of 3H-uracil as a quantitative measure of intracellular development.

D. Schmatz, M. S. Crane, P. K. Murray, 1986, The Journal of protozoology.

The mannitol cycle in Eimeria

D. Schmatz, 1997, Parasitology.

The Antifungal Echinocandin Caspofungin Acetate Kills Growing Cells of Aspergillus fumigatus In Vitro

D. Schmatz, P. Liberator, C. Douglas, 2002, Antimicrobial Agents and Chemotherapy.

Treatment of Pneumocystis carinii pneumonia with 1,3-beta-glucan synthesis inhibitors.

D. Schmatz, R. Schwartz, M. Turner, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Mutations in Ribosomal Protein L10e Confer Resistance to the Fungal-specific Eukaryotic Elongation Factor 2 Inhibitor Sordarin*

D. Schmatz, M. Hsu, J. Nielsen, 1999, The Journal of Biological Chemistry.

Discovery of FabH/FabF Inhibitors from Natural Products

Jun Wang, John F. Barrett, Lynn L. Silver, 2006, Antimicrobial Agents and Chemotherapy.

Structure and chemistry of apicidins, a class of novel cyclic tetrapeptides without a terminal alpha-keto epoxide as inhibitors of histone deacetylase with potent antiprotozoal activities.

D. Schmatz, R. Mosley, G. Bills, 2002, The Journal of organic chemistry.

Purification and Molecular Characterization of cGMP-dependent Protein Kinase from Apicomplexan Parasites

Jeffrey Yuan, D. Schmatz, B. Nare, 2002, The Journal of Biological Chemistry.

Elongation Factor 2 as a Novel Target for Selective Inhibition of Fungal Protein Synthesis*

D. Schmatz, J. Balkovec, M. Hsu, 1998, The Journal of Biological Chemistry.

The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection.

E. Scolnick, A. Woods, D. Zaller, 2006, Bioorganic & Medicinal Chemistry Letters.

Structure, histone deacetylase, and antiprotozoal activities of apicidins B and C, congeners of apicidin with proline and valine substitutions.

D. Schmatz, J. Liesch, D. Zink, 2001, Organic letters.

Pneumocandins from Zalerion arboricola. IV. Biological evaluation of natural and semisynthetic pneumocandins for activity against Pneumocystis carinii and Candida species.

D. Schmatz, J. Balkovec, K. Bartizal, 1992, The Journal of antibiotics.

Pneumocandin D0, a new antifungal agent and potent inhibitor of Pneumocystis carinii.

D. Schmatz, R. Schwartz, O. Hensens, 1994, The Journal of antibiotics.

In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin

D. Schmatz, J. Balkovec, K. Bartizal, 1992, Antimicrobial Agents and Chemotherapy.

The discovery of moriniafungin, a novel sordarin derivative produced by Morinia pestalozzioides.

D. Schmatz, F. Vicente, P. Liberator, 2006, Bioorganic & Medicinal Chemistry.

New semisynthetic pneumocandins with improved efficacies against Pneumocystis carinii in the rat

D. Schmatz, P. Liberator, J. Dropinski, 1995, Antimicrobial agents and chemotherapy.

Antipneumocystis activity of water-soluble lipopeptide L-693,989 in rats

D. Schmatz, J. Anderson, P. Liberator, 1992, Antimicrobial Agents and Chemotherapy.

L-687,781, a new member of the papulacandin family of beta-1,3-D-glucan synthesis inhibitors. I. Fermentation, isolation, and biological activity.

D. Schmatz, G. Garrity, R. Fromtling, 1991, The Journal of antibiotics.

Apicidins: Novel cyclic tetrapeptides as coccidiostats and antimalarial agents from Fusarium pallidoroseum

D. Schmatz, Sheo B. Singh, D. Zink, 1996 .

Selective labeling of intracellular parasite proteins by using ricin.

D. Schmatz, M. Carrington, S. Darkin-Rattray, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase.

D. Zaller, D. Schmatz, S. O'keefe, 2003, Bioorganic & medicinal chemistry letters.

Evidence for and characterization of a mannitol cycle in Eimeria tenella.

D. Schmatz, M. Turner, W. Baginsky, 1989, Molecular and biochemical parasitology.

Use of anti-CD4+ hybridoma cells to induce Pneumocystis carinii in mice

D. Schmatz, J. Smith, K. Bartizal, 1994, Infection and immunity.

Identification of Two Novel Drosophila melanogaster Histamine-gated Chloride Channel Subunits Expressed in the Eye*

Jeffrey Yuan, D. Schmatz, D. Cully, 2002, The Journal of Biological Chemistry.

Parasite exposure elicits a preferential T-cell response involved in protective immunity against Eimeria species in chickens primed by an internal-image anti-idiotypic antibody

D. Schmatz, H. Tse, B. Bhogal, 1989, Infection and immunity.

Anti-idiotypic antibody with potential use as an Eimeria tenella sporozoite antigen surrogate for vaccination of chickens against coccidiosis

D. Schmatz, B. Bhogal, Y. Karkhanis, 1988, Infection and immunity.

Synthesis and biological activity of imidazopyridine anticoccidial agents: Part II.

D. Schmatz, P. Liberator, M. Fisher, 2007, European journal of medicinal chemistry.

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

Jun Wang, Olga Genilloud, Sang Ho Lee, 2006, Nature.

SAR of 3,4-dihydropyrido[3,2-d]pyrimidone p38 inhibitors.

D. Zaller, D. Schmatz, S. O'keefe, 2003, Bioorganic & Medicinal Chemistry Letters.

p38MAP kinase inhibitors. Part 1: design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold.

D. Zaller, D. Schmatz, S. O'keefe, 2003, Bioorganic & medicinal chemistry letters.

Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones.

Bernard K. Choi, A. Woods, D. Zaller, 2003, Journal of medicinal chemistry.

Synthesis of nodulisporic acid 2' '-oxazoles and 2' '-thiazoles.

D. Schmatz, R. Berger, M. Fisher, 2001, Organic letters.

Synthesis and SAR studies of very potent imidazopyridine antiprotozoal agents.

D. Schmatz, P. Liberator, M. Fisher, 2006, Bioorganic & medicinal chemistry letters.

Synthesis and biological activity of anticoccidial agents: 5,6-diarylimidazo[2,1-b][1,3]thiazoles.

D. Schmatz, P. Liberator, M. Fisher, 2008, Bioorganic & medicinal chemistry letters.

Determination of Selectivity and Efficacy of Fatty Acid Synthesis Inhibitors*

D. Schmatz, D. Cully, R. Painter, 2005, Journal of Biological Chemistry.

Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1.

D. Schmatz, R. Myers, M. Fisher, 2001, Bioorganic & medicinal chemistry letters.

N-alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives with heterocyclic substitutions as potent and broad spectrum anticoccidial agents.

D. Schmatz, P. Liberator, M. Fisher, 2008, Bioorganic & medicinal chemistry letters.

Nodulisporic acid side-chain modifications: access to the 2", 3", 4", and 6" registers.

D. Schmatz, M. Fisher, M. Wyvratt, 2003, Bioorganic & medicinal chemistry letters.

Nodulisporic acid opens insect glutamate-gated chloride channels: identification of a new high affinity modulator.

D. Schmatz, J. Schaeffer, V. Warren, 2000, Biochemistry.

Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin.

D. Schmatz, D. Hunt, D. Cully, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Efficacy of MK-991 (L-743,872), a Semisynthetic Pneumocandin, in Murine Models ofPneumocystis carinii

Dennis Schmatz, James M. Balkovec, James F. Dropinski, 1998, Antimicrobial Agents and Chemotherapy.

Species-specific inhibition of fungal protein synthesis by sordarin: identification of a sordarin-specificity region in eukaryotic elongation factor 2.

D. Schmatz, M. Hsu, P. Liberator, 2001, Microbiology.

Alkyl side-chain derivatives of sordaricin as potent antifungal agents against yeast.

D. Schmatz, J. Balkovec, M. Hsu, 1998, Bioorganic & medicinal chemistry letters.

Quantitative PCR Assay To MeasureAspergillus fumigatus Burden in a Murine Model of Disseminated Aspergillosis: Demonstration of Efficacy of Caspofungin Acetate

D. Schmatz, J. Anderson, P. Liberator, 2001, Antimicrobial Agents and Chemotherapy.

Mouse model for Pneumocystis carinii pneumonia that uses natural transmission to initiate infection

D. Schmatz, M. Powles, L. Pittarelli, 1992, Infection and immunity.

Treatment ofPneumocystis carinji pneumonia with1,3-f3-glucan synthesis inhibitors

D. Schmatz, K. Wilson, R. Fromtling, 1990 .

Aerosolized L-693,989 for Pneumocystis carinii prophylaxis in rats

M A Powles, D C McFadden, P A Liberator, 1994, Antimicrobial Agents and Chemotherapy.

Biosynthesis and catabolism of mannitol is developmentally regulated in the protozoan parasite Eimeria tenella.

D. Schmatz, B. Nare, R. Myers, 1999, The Journal of parasitology.

The mannitol cycle--a new metabolic pathway in the Coccidia.

D. Schmatz, 1989, Parasitology today.

In Vitro Cultivation of the Avian Coccidia

D. Schmatz, 1987 .

SYSTEMIC EFFICACY OF NODULISPORAMIDES AGAINST FLEAS ON DOGS

D. Schmatz, B. Pikounis, M. Fisher, 2001, The Journal of parasitology.

Systemic efficacy of nodulisporic acid against fleas on dogs.

D. Schmatz, P. Meinke, J. Ondeyka, 2001, The Journal of parasitology.

Side-chain homologation of nodulisporic acid: synthesis of potent new dienyl derivatives.

D. Schmatz, M. Fisher, M. Wyvratt, 2002, Bioorganic & medicinal chemistry letters.

Chemical modification of nodulisporic acid A: preliminary structure-activity relationships.

D. Schmatz, T. Shih, M. Fisher, 2000, Bioorganic & medicinal chemistry letters.

Chicken T lymphocyte clones with specificity for Eimeria tenella. I. Generation and functional characterization.

D. Schmatz, H. Tse, B. Bhogal, 1986, Journal of immunology.

Synthesis and SAR studies of potent imidazopyridine anticoccidial agents.

D. Schmatz, P. Liberator, M. Fisher, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of 2-(4-fluorophenyl)-3-pyrimidin-4-ylimidazo[1,2-a]pyridine derivatives as anticoccidial agents.

D. Schmatz, P. Liberator, M. Fisher, 2006, Bioorganic & medicinal chemistry letters.

MK-4815, a Potential New Oral Agent for Treatment of Malaria

D. Schmatz, B. Nare, P. Liberator, 2012, Antimicrobial Agents and Chemotherapy.

Hydroxylated N-alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives as potent broad-spectrum anticoccidial agents.

D. Schmatz, P. Liberator, M. Fisher, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents.

D. Schmatz, P. Liberator, M. Fisher, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and SAR studies of diarylpyrrole anticoccidial agents.

D. Schmatz, P. Liberator, M. Fisher, 2006, Bioorganic & medicinal chemistry letters.

Chapter 17. Antiparasitic Agents

D. Schmatz, J. Schaeffer, 1991 .

Discovery of the development candidate N-tert-butyl nodulisporamide: a safe and efficacious once monthly oral agent for the control of fleas and ticks on companion animals.

Pierre Demontigny, D. Schmatz, M. Fisher, 2009, Journal of medicinal chemistry.

Separation of individual stages of Trypanosoma cruzi grown in cell culture by continuous free-flow electrophoresis.

D. Schmatz, R. Boltz, P. K. Murray, 1982, The Journal of protozoology.

Trypanosoma cruzi: separation of broad and slender trypomastigotes using a continuous hypaque gradient

D. Schmatz, R. Boltz, P. K. Murray, 1983, Parasitology.

Use of beta-1,3-glucan-specific antibody to study the cyst wall of Pneumocystis carinii and effects of pneumocandin B0 analog L-733,560

D. Schmatz, M. Aikawa, H. Fujioka, 1994, Antimicrobial Agents and Chemotherapy.

Development of a scintillation proximity assay for histone deacetylase using a biotinylated peptide derived from histone-H4.

M. Bednarek, D. Schmatz, B. Nare, 1999, Analytical biochemistry.

Molecular Cloning and Functional Expression of Mannitol-1-phosphatase from the Apicomplexan Parasite Eimeria tenella *

D. Schmatz, R. Myers, P. Liberator, 1998, The Journal of Biological Chemistry.

Trypanosoma cruzi: selective isolation of pure trypomastigotes from cultured muscle cells.

D. Schmatz, P. K. Murray, 1981, The Journal of parasitology.

Cultivation of Trypanosoma cruzi in irradiated muscle cells: improved synchronization and enhanced trypomastigote production

D. Schmatz, P. K. Murray, 1982, Parasitology.

Novel Enzyme-Linked Immunoassay To Determine Nanogram Levels of Pneumocandins in Human Plasma

D. Schmatz, Y. Karkhanis, 1998, Journal of Clinical Microbiology.

NITROPHENIDE (MEGASUL™) BLOCKS EIMERIA TENELLA DEVELOPMENT BY INHIBITING THE MANNITOL CYCLE ENZYME MANNITOL-1-PHOSPHATE DEHYDROGENASE

D. Schmatz, B. Nare, R. Myers, 2001, Journal of Parasitology.

Identification and possible role of D-mannitol and 2-O-methyl-chiro-inositol (quebrachitol) in Eimeria tenella.

D. Schmatz, M. Turner, M. Dashkevicz, 1988, Molecular and biochemical parasitology.

Eimeria tenella: in vitro development in irradiated bovine kidney cells

D. Schmatz, M. Habbersett, M. S. Crane, 1984, Parasitology.

Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents.

D. Schmatz, R. Myers, M. Fisher, 2000, Journal of medicinal chemistry.

Synthesis and biological activity of imidazopyridine anticoccidial agents: part I.

D. Schmatz, P. Liberator, M. Fisher, 2007, European journal of medicinal chemistry.

Synthesis and biological activity of anticoccidial agents: 2,3-diarylindoles.

D. Schmatz, P. Liberator, M. Fisher, 2009, Bioorganic & Medicinal Chemistry Letters.

Comparative study of antipneumocystis agents in rats by using a Pneumocystis carinii-specific DNA probe to quantitate infection

D. Schmatz, J. Anderson, M. Becker-Hapak, 1992, Journal of clinical microbiology.

Synthesis and Antifungal Activity of Novel Cationic Pneumocandin Bo Derivatives.

D. Schmatz, R. Zambias, J. Balkovec, 1994 .

Preparation and structure-activity relationships of simplified analogues of the antifungal agent cilofungin: a total synthesis approach.

D. Schmatz, J. Heck, R. Zambias, 1992, Journal of medicinal chemistry.

Coprophilin: an anticoccidial agent produced by a dung inhabiting fungus.

D. Schmatz, G. Bills, R. Giacobbe, 1998, Bioorganic & medicinal chemistry letters.

Treatment and prevention of Pneumocystis carinii pneumonia and further elucidation of the P. carinii life cycle with 1,3-beta-glucan synthesis inhibitor L-671,329.

D. Schmatz, J. Anderson, P. Liberator, 1991, The Journal of protozoology.

Amylopectin Synthase of Eimeria tenella: Identification and Kinetic Characterization

D. Schmatz, Y. Karkhanis, J. Allocco, 1993, The Journal of eukaryotic microbiology.

Potent 4-aminopiperidine based antimalarial agents.

Kristin M. Brinner, D. Schmatz, J. Ellman, 2005, Bioorganic & medicinal chemistry letters.