P. McKeown-Longo

发表

Receptor-mediated endocytosis of vitronectin is regulated by its conformational state.

T. S. Panetti, P. McKeown-Longo, 1993, The Journal of biological chemistry.

PAI1 stimulates assembly of the fibronectin matrix in osteosarcoma cells through crosstalk between the αvβ5 and α5β1 integrins

P. McKeown-Longo, D. Vial, 2008, Journal of Cell Science.

Binding of plasma fibronectin to cell layers of human skin fibroblasts

P. McKeown-Longo, D. Mosher, 1983, The Journal of cell biology.

Interaction of the 70,000-mol-wt amino-terminal fragment of fibronectin with the matrix-assembly receptor of fibroblasts

P. McKeown-Longo, D. Mosher, 1985, The Journal of cell biology.

Polarized fibronectin secretion and localized matrix assembly sites correlate with subendothelial matrix formation.

P. McKeown-Longo, A. Kowalczyk, R. Tulloh, 1990, Blood.

Transition and Epithelial Cell Invasion Krüppel-Like Factor 8 Induces Epithelial to Mesenchymal

P. McKeown-Longo, M. Hung, W. Xia, 2007 .

Fibronectin in the Tumor Microenvironment Activates a TLR4-dependent Inflammatory Response in Lung Cancer Cells

David M. Jones, P. McKeown-Longo, D. M. Peters, 2020, Journal of Cancer.

TLR4 Ligands Selectively Synergize to Induce Expression of IL-8.

P. McKeown-Longo, C. Horzempa, C. M. Longo, 2017, Advances in wound care.

Conformational remodeling of the fibronectin matrix selectively regulates VEGF signaling

P. McKeown-Longo, A. Ambesi, 2014, Journal of Cell Science.

Alpha v beta 5 integrin receptor-mediated endocytosis of vitronectin is protein kinase C-dependent.

T. S. Panetti, P. McKeown-Longo, C. Horzempa, 1995, The Journal of biological chemistry.

Epidermal Growth Factor (EGF) Regulates α5β1 Integrin Activation State in Human Cancer Cell Lines through the p90RSK-dependent Phosphorylation of Filamin A*

P. McKeown-Longo, D. Vial, 2012, The Journal of Biological Chemistry.

A dual role for caveolin-1 in the regulation of fibronectin matrix assembly by uPAR

P. McKeown-Longo, C. Mastick, E. Monaghan-Benson, 2008, Journal of Cell Science.

The Receptor for Urokinase-type Plasminogen Activator Regulates Fibronectin Matrix Assembly in Human Skin Fibroblasts*

P. McKeown-Longo, C. Wilkins-Port, Elizabeth Monaghan, 2004, Journal of Biological Chemistry.

Assembly of fibronection‐containing extracellular matrix: A glimpse of the machinery

P. McKeown-Longo, D. Mosher, 1985, Biopolymers.

A novel role for the integrin-binding III-10 module in fibronectin matrix assembly

P. McKeown-Longo, D. Hocking, R. Smith, 1996, The Journal of cell biology.

Cultured human fibroblasts synthesize and secrete thrombospondin and incorporate it into extracellular matrix.

P. McKeown-Longo, E. Jaffe, D. Mosher, 1983, Proceedings of the National Academy of Sciences of the United States of America.

The Assembly of the Fibronectin Matrix in Cultured Human Fibroblast Cells

P. McKeown-Longo, 1989 .

Induction of fibronectin matrix assembly in human fibrosarcoma cells by dexamethasone

P. McKeown-Longo, C. Etzler, 1987, The Journal of cell biology.

EDA Fibronectin in Keloids Create a Vicious Cycle of Fibrotic Tumor Formation.

P. McKeown-Longo, R. Clark, Rhiannon M Kelsh, 2015, The Journal of investigative dermatology.

Award Number: W81XWH-10-1-0755 TITLE: Fibronectin Matrix Remodeling in the Regulation of the Inflammatory Response within the Lung: An Early Step in Lung Cancer Progression PRINCIPAL INVESTIGATOR:

A. Prasad, P. McKeown-Longo, D. Ph., 2011 .

Endostatin and anastellin inhibit distinct aspects of the angiogenic process

P. McKeown-Longo, K. Pumiglia, A. Ambesi, 2008, Journal of experimental & clinical cancer research : CR.

Localization of Urokinase Type Plasminogen Activator to Focal Adhesions Requires Ligation of Vitronectin Integrin Receptors

P. McKeown-Longo, C. Wilkins-Port, S. Wilcox-Adelman, 2000, Cell adhesion and communication.

Binding of plasma fibronectin to cell layers of human skin fibroblasts

P. McKeown-Longo, D. Mosher, 1983, The Journal of cell biology.

Basolateral distribution of fibronectin matrix assembly sites on vascular endothelial monolayers is regulated by substratum fibronectin

P. McKeown-Longo, A. Kowalczyk, 1992, Journal of cellular physiology.

Cell adhesion regulates Ser/Thr phosphorylation and proteasomal degradation of HEF1

P. McKeown-Longo, M. Zheng, 2006, Journal of Cell Science.

Stimulation of extracellular matrix remodeling by the first type III repeat in fibronectin

P. McKeown-Longo, R. M. Klein, L. Van De Water, 2003, Journal of Cell Science.

Plasminogen activator inhibitor type I stabilizes vitronectin-dependent adhesions in HT-1080 cells

P. McKeown-Longo, G. Ciambrone, 1990, The Journal of cell biology.

Binding and degradation of platelet thrombospondin by cultured fibroblasts

P. McKeown-Longo, D. Mosher, R. Hanning, 1984, The Journal of cell biology.

The fibronectin synergy site modulates TGF-β-dependent fibroblast contraction

P. McKeown-Longo, L. Water, R. Harmon, 2007 .

Fibronectin-cell surface interactions.

P. McKeown-Longo, 1987, Reviews of infectious diseases.

Fibronectin attenuates increased endothelial monolayer permeability after RGD peptide, anti-alpha 5 beta 1, or TNF-alpha exposure.

P. McKeown-Longo, P. Vincent, T. Curtis, 1995, The American journal of physiology.

TGF-beta1-induced PAI-1 gene expression requires MEK activity and cell-to-substrate adhesion.

P. McKeown-Longo, P. Higgins, S. Kutz, 2001, Journal of cell science.

Extracellular matrix assembly of cell‐derived and plasma‐derived fibronectins by substrate‐attached fibroblasts

P. McKeown-Longo, A. Allio, 1988, Journal of cellular physiology.

Regulation of the Innate Immune Response by Fibronectin: Synergism between the III-1 and EDA Domains

P. McKeown-Longo, M. Zheng, C. Horzempa, 2014, PloS one.

Hyaluronan, Transforming Growth Factor β, and Extra Domain A-Fibronectin: A Fibrotic Triad

P. McKeown-Longo, P. Higgins, 2020, Advances in Wound Care.

Integration of Canonical and Noncanonical Pathways in TLR4 Signaling: Complex Regulation of the Wound Repair Program.

P. McKeown-Longo, P. Higgins, 2017, Advances in wound care.

The First Type III Repeat in Fibronectin Activates an Inflammatory Pathway in Dermal Fibroblasts*

P. McKeown-Longo, M. Zheng, R. You, 2010, The Journal of Biological Chemistry.

Roles of Thrombospondin and Fibronectin in Vascular Injury

P. McKeown-Longo, D. Mosher, 1985 .

Metabolism of thrombospondin and fibronectin by endothelial cells

P. McKeown-Longo, D. Mosher, E. Williams, 1984 .

Coordinate regulation of fibronectin matrix assembly by the plasminogen activator system and vitronectin in human osteosarcoma cells

P. McKeown-Longo, D. Vial, E. Monaghan-Benson, 2006, Cancer Cell International.

Hepatic fibronectin matrix turnover in rats: involvement of the asialoglycoprotein receptor.

P. McKeown-Longo, P. Vincent, F. Blumenstock, 1999, American journal of physiology. Gastrointestinal and liver physiology.

AGI December 40/6

P. McKeown-Longo, P. Vincent, F. Blumenstock, 1999 .

Hepatic fibronectin matrix turnover in rats: involvement of the asialoglycoprotein receptor.

P. McKeown-Longo, P. Vincent, F. Blumenstock, 1999, The American journal of physiology.

Circulating cellular fibronectin may be a natural ligand for the hepatic asialoglycoprotein receptor: Possible pathway for fibronectin deposition and turnover in the rat liver

P. McKeown-Longo, R. Rebres, F. Blumenstock, 1998, Hepatology.

Integrin α4β1 and TLR4 Cooperate to Induce Fibrotic Gene Expression in Response to Fibronectin's EDA Domain.

P. McKeown-Longo, A. Ambesi, Ceyda Bertram, 2017, The Journal of investigative dermatology.

The uPA receptor and the somatomedin B region of vitronectin direct the localization of uPA to focal adhesions in microvessel endothelial cells.

P. McKeown-Longo, Roman M. Salasznyk, M. Zheng, 2007, Matrix biology : journal of the International Society for Matrix Biology.

Activation of Distinct α5β1-mediated Signaling Pathways by Fibronectin's Cell Adhesion and Matrix Assembly Domains

P. McKeown-Longo, D. Hocking, J. Sottile, 1998, The Journal of cell biology.

High‐Affinity Binding of Fibronectin to Cultured Kupffer Cells

P. McKeown-Longo, J. Mazurkiewicz, J. Dias, 1990, Journal of leukocyte biology.

Preparation and characterization of an antiserum against purified proteoglycan link proteins from avian cartilage.

P. McKeown-Longo, K. Sparks, P. Goetinck, 1982, Collagen and related research.

Physical and immunochemical properties of low-buoyant-density proteoglycans from avian cartilage.

P. McKeown-Longo, K. Sparks, P. Goetinck, 1981, Archives of biochemistry and biophysics.

Anastellin, the Angiostatic Fibronectin Peptide, Is a Selective Inhibitor of Lysophospholipid Signaling

P. McKeown-Longo, A. Ambesi, 2009, Molecular Cancer Research.

Vitronectin regulates the synthesis and localization of urokinase-type plasminogen activator in HT-1080 cells.

P. McKeown-Longo, G. Ciambrone, 1992, The Journal of biological chemistry.

Binding of soluble fibronectin and its subsequent incorporation into the extracellular matrix by early and late passage human skin fibroblasts.

P. McKeown-Longo, D. Mann, A. J. Millis, 1988, The Journal of biological chemistry.

Role of EGFR expression levels in the regulation of integrin function by EGF

P. McKeown-Longo, D. Vial, Paula J. McKeown‐Longo, 2016, Molecular carcinogenesis.

Heparan sulfate proteoglycans function in the binding and degradation of vitronectin by fibroblast monolayers.

P. McKeown-Longo, C. Wilkins-Port, 1996, Biochemistry and cell biology = Biochimie et biologie cellulaire.

The alpha v beta 5 integrin receptor regulates receptor-mediated endocytosis of vitronectin.

P. McKeown-Longo, T. Panetti, 1993, The Journal of biological chemistry.

Anastellin, a fragment of the first type III repeat of fibronectin, inhibits extracellular signal-regulated kinase and causes G(1) arrest in human microvessel endothelial cells.

P. McKeown-Longo, K. Pumiglia, R. M. Klein, 2005, Cancer research.

Fragment of the First Type III Repeat of Fibronectin , Inhibits Extracellular Signal-Regulated Kinase and Causes G 1 Arrest in Human Microvessel Endothelial Cells

P. McKeown-Longo, K. Pumiglia, R. M. Klein, 2004 .

The amino-terminal matrix assembly domain of fibronectin stabilizes cell shape and prevents cell cycle progression.

P. McKeown-Longo, P. Vincent, P. Higgins, 1999, Journal of cell science.

Urokinase-type Plasminogen Activator Receptor Regulates a Novel Pathway of Fibronectin Matrix Assembly Requiring Src-dependent Transactivation of Epidermal Growth Factor Receptor*

P. McKeown-Longo, E. Monaghan-Benson, 2006, Journal of Biological Chemistry.

Inhibition of Fibronectin Matrix Assembly by the Heparin-binding Domain of Vitronectin*

P. McKeown-Longo, D. Hocking, R. Fässler, 1999, The Journal of Biological Chemistry.

Localization of fibronectin matrix assembly sites on fibroblasts and endothelial cells.

P. McKeown-Longo, A. Kowalczyk, R. A. Christopher, 1997, Journal of cell science.

Mechanism of formation of disulfide-bonded multimers of plasma fibronectin in cell layers of cultured human fibroblasts.

P. McKeown-Longo, D. Mosher, 1984, The Journal of biological chemistry.

Lung matrix incorporation of plasma fibronectin reduces vascular permeability in postsurgical bacteremia.

P. McKeown-Longo, P. Vincent, T. Brien, 1999, The American journal of physiology.

Immunofluorescent analysis of plasma fibronectin incorporation into the lung during acute inflammatory vascular injury.

P. McKeown-Longo, P. Vincent, F. Minnear, 1993, The American review of respiratory disease.

Incorporation of circulating fibronectin into various tissues during sepsis: colocalization with endogenous tissue fibronectin.

P. McKeown-Longo, P. Vincent, F. Blumenstock, 1991, Experimental and molecular pathology.

Structure and Function of Vitronectin

P. McKeown-Longo, 正男林, T. Panetti, 1996 .

TNF-α-induced matrix Fn disruption and decreased endothelial integrity are independent of Fn proteolysis.

P. McKeown-Longo, P. Vincent, T. Curtis, 1998, American journal of physiology. Lung cellular and molecular physiology.

The α4β1 integrin and the EDA domain of fibronectin regulate a profibrotic phenotype in dermal fibroblasts.

K. Sekiguchi, P. McKeown-Longo, J. Peters, 2015, Matrix biology : journal of the International Society for Matrix Biology.

The First Type III Domain of Fibronectin is Associated with the Expression of Cytokines within the Lung Tumor Microenvironment

David M. Jones, A. Prasad, P. McKeown-Longo, 2011, Journal of Cancer.

Fibronectin's III-1 module contains a conformation-dependent binding site for the amino-terminal region of fibronectin.

P. McKeown-Longo, D. Hocking, J. Sottile, 1994, The Journal of biological chemistry.

Fibronectin Functions as a Selective Agonist for Distinct Toll-like Receptors in Triple-Negative Breast Cancer

P. McKeown-Longo, A. Ambesi, Pranav Maddali, 2022, Cells.

Regulation of HEF1 Expression and Phosphorylation by TGF-β1 and Cell Adhesion*

P. McKeown-Longo, Mingzhe Zheng, Paula J. McKeown-Longo, 2002, The Journal of Biological Chemistry.

The fibronectin III-1 domain activates a PI3-Kinase/Akt signaling pathway leading to αvβ5 integrin activation and TRAIL resistance in human lung cancer cells

P. McKeown-Longo, Christina Cho, C. Horzempa, 2016, BMC Cancer.

The alphavbeta5 integrin functions as an endocytic receptor for vitronectin.

P. McKeown-Longo, L. M. Memmo, 1998, Journal of cell science.

Vitronectin's Basic Domain is a Syndecan Ligand which Functions in transto Regulate Vitronectin Turnover

P. McKeown-Longo, R. Sanderson, C. Wilkins-Port, 2003, Cell communication & adhesion.

Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion.

P. McKeown-Longo, M. Hung, W. Xia, 2007, Cancer research.

αvβ5 Integrin Receptor-mediated Endocytosis of Vitronectin Is Protein Kinase C-dependent (*)

P. McKeown-Longo, C. Horzempa, S. Wilcox, 1995, The Journal of Biological Chemistry.

Absence of proteoglycan core protein in the cartilage mutant nanomelia

P. McKeown-Longo, W. Argraves, P. Goetinck, 1981, FEBS letters.

Ligation of Endothelial αvβ3 Integrin Increases Capillary Hydraulic Conductivity of Rat Lung

P. McKeown-Longo, S. Albelda, J. Bhattacharya, 1995 .

Ligation of endothelial alpha v beta 3 integrin increases capillary hydraulic conductivity of rat lung.

P. McKeown-Longo, S. Albelda, J. Bhattacharya, 1995, Circulation research.

Regulation of p38 MAP kinase by anastellin is independent of anastellin's effect on matrix fibronectin.

P. McKeown-Longo, R. M. Klein, M. Zheng, 2009, Matrix biology : journal of the International Society for Matrix Biology.

Localization of urokinase to focal adhesions by human fibrosarcoma cells synthesizing recombinant vitronectin.

P. McKeown-Longo, P. Higgins, S. Wilcox, 1996, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Extracellular matrix incorporation of normal and NEM-alkylated fibronectin: liver and spleen deposition.

P. McKeown-Longo, P. Vincent, R. Rebres, 1995, The American journal of physiology.

Topographical changes in extracellular matrix: Activation of TLR4 signaling and solid tumor progression.

P. McKeown-Longo, Rhiannon M Kelsh, 2013, Trends in cancer research.

The fibronectin III-1 domain activates a PI3-Kinase/Akt signaling pathway leading to αvβ5 integrin activation and TRAIL resistance in human lung cancer cells

David M. Jones, P. McKeown-Longo, Christina Cho, 2016, BMC Cancer.

Induction of pro-inflammatory genes by fibronectin DAMPs in three fibroblast cell lines: Role of TAK1 and MAP kinases

P. McKeown-Longo, A. Ambesi, Pranav Maddali, 2023, PloS one.

Quantification of fibronectin matrix assembly sites using a novel ELISA assay.

P. McKeown-Longo, M. Zheng, A. Ambesi, 2007, Matrix biology : journal of the International Society for Matrix Biology.

Effect of fibronectin on permeability of normal and TNF-treated lung endothelial cell monolayers.

P. McKeown-Longo, P. Vincent, T. Saba, 1993, The American journal of physiology.

Regulation of HEF1 expression and phosphorylation by TGF-beta 1 and cell adhesion.

P. McKeown-Longo, Mingzhe Zheng, Paula J McKeown-Longo, 2002, The Journal of biological chemistry.

Degradation of distinct forms of multimeric vitronectin by human fibroblasts.

P. McKeown-Longo, C. Wilkins-Port, 1998, Biochimica et biophysica acta.

Induction of fibronectin matrix assembly in human fibrosarcoma cells by dexamethasone

P. McKeown-Longo, Carol A Etzler, Mckeown-Longo, 1987, The Journal of cell biology.

Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion.

P. McKeown-Longo, M. Hung, W. Xia, 2007, Cancer research.

Cryptic activity within the Type III1 domain of fibronectin regulates tissue inflammation and angiogenesis.

P. McKeown-Longo, Christina Cho, A. Ambesi, 2015, Current topics in peptide & protein research.

The fibronectin synergy site modulates TGF-beta-dependent fibroblast contraction.

P. McKeown-Longo, R. Harmon, L. Van De Water, 2007, Biochemical and biophysical research communications.