K. Varnäs

发表

Arterial Input Function Derived from Pairwise Correlations Between PET-image Voxels

A. Lansner, C. Halldin, M. Schain, 2013, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain

C. Halldin, K. Varnäs, H. Hall, 2004, Human brain mapping.

The pro-psychotic metabotropic glutamate receptor compounds fenobam and AZD9272 share binding sites with monoamine oxidase-B inhibitors in humans

C. Halldin, K. Varnäs, L. Farde, 2020, Neuropharmacology.

The metabotropic glutamate receptor 5 radioligand [11C]AZD9272 identifies unique binding sites in primate brain

C. Halldin, K. Varnäs, L. Farde, 2018, Neuropharmacology.

Integrated Strategy for Use of Positron Emission Tomography in Nonhuman Primates to Confirm Multitarget Occupancy of Novel Psychotropic Drugs: An Example with AZD3676

C. Halldin, K. Varnäs, L. Farde, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing.

C. Halldin, K. Varnäs, L. Farde, 2015, Nuclear medicine and biology.

Radiolabeling of the cannabinoid receptor agonist AZD1940 with carbon-11 and PET microdosing in non-human primate.

B. Gulyás, C. Halldin, K. Varnäs, 2013, Nuclear medicine and biology.

Dose-dependent binding of AZD3783 to brain 5-HT 1B receptors in non-human primates and human subjects: a positron emission tomography study

C. Halldin, K. Varnäs, L. Farde, 2011 .

Quantitative Analysis of [11C]AZ10419369 Binding to 5-HT1B Receptors in Human Brain

C. Halldin, K. Varnäs, L. Farde, 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Dose-dependent binding of AZD3783 to brain 5-HT1B receptors in non-human primates and human subjects: a positron emission tomography study with [11C]AZ10419369

C. Halldin, K. Varnäs, L. Farde, 2011, Psychopharmacology.

Radiosynthesis of the candidate β‐amyloid radioligand [11C]AZD2184: Positron emission tomography examination and metabolite analysis in cynomolgus monkeys

B. Gulyás, C. Halldin, K. Varnäs, 2010, Synapse.

Regional thinning of the cerebral cortex in schizophrenia: Effects of diagnosis, age and antipsychotic medication

A. Frigessi, I. Agartz, K. Walhovd, 2008, Schizophrenia Research.

Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects

Christer Halldin, Lars Farde, Katarina Varnäs, 2012, EJNMMI Research.

Grey and White Matter Proportional Relationships in the Cerebellar Vermis Altered in Schizophrenia

I. Agartz, G. Okugawa, K. Varnäs, 2009, The Cerebellum.

Neurokinin-3 Receptor Binding in Guinea Pig, Monkey, and Human Brain: In Vitro and in Vivo Imaging Using the Novel Radioligand, [18F]Lu AF10628

C. Halldin, K. Varnäs, L. Farde, 2016, The international journal of neuropsychopharmacology.

Synthesis and in vitro autoradiographic evaluation of a novel high-affinity radioiodinated ligand for imaging brain cannabinoid subtype-1 receptors.

Sean R. Donohue, B. Gulyás, C. Halldin, 2009, Bioorganic & medicinal chemistry letters.

PET imaging of [11C]PBR28 in Parkinson’s disease patients does not indicate increased binding to TSPO despite reduced dopamine transporter binding

P. Svenningsson, C. Halldin, K. Varnäs, 2018, European Journal of Nuclear Medicine and Molecular Imaging.

A PET study comparing receptor occupancy by five selective cannabinoid 1 receptor antagonists in non-human primates

Sean R. Donohue, B. Gulyás, S. Hjorth, 2016, Neuropharmacology.

PET microdosing of CNS drugs

K. Varnäs, M. Schou, 2017, Clinical and Translational Imaging.

Preclinical Comparison of the Blood–brain barrier Permeability of Osimertinib with Other EGFR TKIs

N. Karp, D. Nguyen, A. Windhorst, 2020, Clinical Cancer Research.

GABAA receptor occupancy by subtype selective GABAAα2,3 modulators: PET studies in humans

C. Halldin, K. Varnäs, L. Farde, 2016, Psychopharmacology.

Effects of sevoflurane anaesthesia on radioligand binding to monoamine oxidase-B in vivo

C. Halldin, K. Varnäs, L. Farde, 2020, British journal of anaesthesia.

Longitudinal microPET imaging of the zQ175 mouse model of Huntington´s disease shows in vivo changes of molecular targets in the striatum and the cerebral cortex

J. Wityak, K. Varnäs, A. Forsberg, 2016 .

A PET study in healthy subjects of brain exposure of 11C-labelled osimertinib – A drug intended for treatment of brain metastases in non-small cell lung cancer

C. Halldin, K. Varnäs, L. Farde, 2020, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

A PET study with [11C]AZ10419369 to determine brain 5-HT1B receptor occupancy of zolmitriptan in healthy male volunteers

C. Halldin, K. Varnäs, L. Farde, 2013, Cephalalgia : an international journal of headache.

Associations between cognition and serotonin receptor 1B binding in patients with major depressive disorder – A pilot study

C. Halldin, K. Varnäs, N. Lindefors, 2017, Psychiatry Research: Neuroimaging.

Synthesis, biological and autoradiographic evaluation of a novel Tc-99m radioligand derived from WAY 100635 with high affinity for the 5-HT(1A) receptor and the alpha1-adrenergic receptor.

P. Brust, C. Halldin, K. Varnäs, 2002, Nuclear medicine and biology.

Estimation of drug receptor occupancy when non-displaceable binding differs between brain regions – extending the simplified reference tissue model.

K. Varnäs, M. Karlsson, A. Hooker, 2015, British journal of clinical pharmacology.

Low brain CB1 receptor occupancy by a second generation CB1 receptor antagonist TM38837 in comparison with rimonabant in nonhuman primates: A PET study

B. Gulyás, C. Halldin, K. Varnäs, 2014, Synapse.

[11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins.

J. Wityak, C. Halldin, K. Varnäs, 2021, Journal of medicinal chemistry.

Discovery of a Novel Muscarinic Receptor PET Radioligand with Rapid Kinetics in the Monkey Brain.

K. Varnäs, S. Finnema, M. Schou, 2017, ACS chemical neuroscience.

Altered striatal dopamine levels in Parkinson’s disease VPS35 D620N mutant transgenic aged mice

B. Gulyás, C. Halldin, K. Varnäs, 2020, Molecular brain.

Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor.

K. Varnäs, P. Johnström, Xiaolin Zhang, 2015, Journal of medicinal chemistry.

Synthesis, Biodistribution, and Radiation Dosimetry of a Novel mGluR5 Radioligand: 18F-AZD9272

C. Halldin, K. Varnäs, L. Farde, 2020, ACS chemical neuroscience.

Development of [ Carbonyl-11C]AZ13198083, a Novel Histamine Type-3 Receptor Radioligand with Favorable Kinetics.

K. Varnäs, M. Moein, S. Finnema, 2018, ACS chemical neuroscience.

New halogenated [11C]WAY analogues, [11C]6FPWAY and [11C]6BPWAY--radiosynthesis and assessment as radioligands for the study of brain 5-HT1A receptors in living monkey.

H. Wikström, J. Sandell, C. Halldin, 2001, Nuclear medicine and biology.

Evaluation of Two Automated Methods for PET Region of Interest Analysis

C. Halldin, M. Schain, K. Varnäs, 2014, Neuroinformatics.

Modeling of PET data in CNS drug discovery and development

K. Varnäs, L. Farde, A. Varrone, 2013, Journal of Pharmacokinetics and Pharmacodynamics.

Autoradiographic evaluation of [11C]vinpocetine binding in the human postmortem brain.

J Sandell, J. Sandell, C. Halldin, 2002, Acta Biologica Hungarica.

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models

I. Barrett, K. Varnäs, K. Valerie, 2018, Science Advances.

Brain exposure of the ATM inhibitor AZD1390 in humans - a positron emission tomography (PET) study.

C. Halldin, K. Varnäs, L. Farde, 2020, Neuro-oncology.

Distribution of Serotonin Receptors and Transporters in the Human Brain: Implications for Psychosis

K. Varnäs, 2005 .

Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity

Matthew Grist, P. Jänne, K. Varnäs, 2016, Clinical Cancer Research.

Detection of amyloid in Alzheimer’s disease with positron emission tomography using [11C]AZD2184

Christer Halldin, Lars Farde, Katarina Varnäs, 2009, European Journal of Nuclear Medicine and Molecular Imaging.

Synthesis and biological evaluation of technetium(III) mixed-ligand complexes with high affinity for the cerebral 5-HT(1A) receptor and the alpha1-adrenergic receptor.

C. Halldin, K. Varnäs, H. Hall, 2002, Nuclear medicine and biology.

The 5-HT1B receptor - a potential target for antidepressant treatment

Y. Okubo, K. Varnäs, J. Lundberg, 2018, Psychopharmacology.

Large Variation in Brain Exposure of Reference CNS Drugs: a PET Study in Nonhuman Primates

Christer Halldin, Lars Farde, Katarina Varnäs, 2015, The international journal of neuropsychopharmacology.

Autoradiographic mapping of synaptic vesicle glycoprotein 2A in non-human primate and human brain.

C. Halldin, K. Varnäs, V. Stepanov, 2020, Synapse.

Development of a central nicotinic acetylcholine receptor radioligand, 5‐methyl‐A‐85380, and postmortem autoradiography in human brain

C. Crouzel, J. Sandell, C. Halldin, 2001 .

Clinical Validation of 18F-AZD4694, an Amyloid-β–Specific PET Radioligand

Christer Halldin, Lars Farde, Katarina Varnäs, 2012, The Journal of Nuclear Medicine.

Synthesis, Radiolabeling, and In Vivo Pharmacokinetic Evaluation of the Amyloid Beta Radioligand [11C]AZD4694 in Nonhuman Primates

B. Gulyás, J. Sandell, C. Halldin, 2014, Molecular Imaging and Biology.

Low background and high contrast PET imaging of amyloid-β with [11C]AZD2995 and [11C]AZD2184 in Alzheimer’s disease patients

Christer Halldin, Lars Farde, Katarina Varnäs, 2013, European Journal of Nuclear Medicine and Molecular Imaging.

Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease.

Christer Halldin, Lars Farde, Katarina Varnäs, 2015, Brain : a journal of neurology.

Synthesis and Autoradiography of Novel F-18 Labeled Reversible Radioligands for Detection of Monoamine Oxidase B

S. Luthra, C. Halldin, K. Varnäs, 2020, ACS chemical neuroscience.

Evaluation of Two Automated Methods for PET Region of Interest Analysis

Christer Halldin, Lars Farde, Katarina Varnäs, 2014, Neuroinformatics.

Positron emission tomography imaging of 5-hydroxytryptamine1B receptors in Parkinson's disease

Christer Halldin, Lars Farde, Katarina Varnäs, 2014, Neurobiology of Aging.

[11C]AZ10419369: A selective 5-HT1B receptor radioligand suitable for positron emission tomography (PET). Characterization in the primate brain

Christer Halldin, Lars Farde, Nicholas Seneca, 2008, NeuroImage.

Autoradiographic mapping of 5-HT1B and 5-HT1D receptors in the post mortem human brain using [3H]GR 125743

Katarina Varnäs, Göran Sedvall, Håkan Hall, 2001, Brain Research.

Distribution of 5-HT4 receptors in the postmortem human brain—an autoradiographic study using [125I]SB 207710

Victor W. Pike, Christer Halldin, Katarina Varnäs, 2003, European Neuropsychopharmacology.

Amphetamine Decreases α2C-Adrenoceptor Binding of [11C]ORM-13070: A PET Study in the Primate Brain

C. Halldin, M. Scheinin, K. Varnäs, 2015, The international journal of neuropsychopharmacology.

Radiosynthesis and evaluation of new α1-adrenoceptor antagonists as PET radioligands for brain imaging.

B. Gulyás, C. Halldin, K. Varnäs, 2013, Nuclear medicine and biology.

Mapping the distribution of serotonin transporter in the human brainstem with high-resolution PET: Validation using postmortem autoradiography data

P. Fazio, K. Varnäs, C. Halldin, 2016, NeuroImage.

IMAGING DRUG DELIVERY TO THE CNS USING TRANSLATIONAL POSITRON EMISSION TOMOGRAPHY STUDIES

K. Varnäs, L. Farde, Chi-Ming Lee, 2013 .

Distribution of 5-HT7 receptors in the human brain: a preliminary autoradiographic study using [ 3 H ]SB-269970

Katarina Varnäs, Jari Tiihonen, Erkki Tupala, 2004, Neuroscience Letters.

Serotonin 1B receptor density mapping of the human brainstem using positron emission tomography and autoradiography

B. Gulyás, C. Halldin, K. Varnäs, 2021, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Brain-derived neurotrophic factor polymorphisms and frontal cortex morphology in schizophrenia

I. Agartz, E. Jönsson, L. Terenius, 2008, Psychiatric genetics.

Amphetamine decreases binding of the novel alpha2C-adrenoreceptor radioligand [11C]ORM-13070 in monkey brain

B. Gulyás, K. Varnäs, C. Halldin, 2010, NeuroImage.

Regional expression of 5‐HT1B receptor mRNA in the human brain

Y. Hurd, K. Varnäs, H. Hall, 2005, Synapse.

Local and covariate-modulated false discovery rates applied in neuroimaging

Glenn Lawyer, Egil Ferkingstad, Katarina Varnäs, 2009, NeuroImage.

The 5-HT1B receptor - a potential target for antidepressant treatment

Y. Okubo, K. Varnäs, J. Lundberg, 2018, Psychopharmacology.

Antidepressant effects on serotonin 1A/1B receptors in the rat brain using a gene x environment model

P. Svenningsson, D. Pine, D. Luckenbaugh, 2014, Neuroscience Letters.