P. Suzdak

发表

The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats.

A. Fink-Jensen, P. Suzdak, Michael D B Swedberg, 1992, European journal of pharmacology.

Characterization of novel ligands for wild-type and natural mutant diazepam-insensitive benzodiazepine receptors.

P. Suzdak, G. Wong, E. Korpi, 1995, European journal of pharmacology.

Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes.

S. Paul, P. Suzdak, R. D. Schwartz, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Xanomeline: A selective muscarinic agonist for the treatment of Alzheimer's disease

F. Bymaster, L. Farde, P. Suzdak, 1997 .

Ketomethylene and (cyanomethylene)amino pseudopeptide analogues of the C-terminal hexapeptide of neurotensin.

P. Suzdak, I. Gomez-Monterrey, M. García-López, 1995, Journal of medicinal chemistry.

Systemic Administration of the Immunophilin Ligand GPI 1046 in MPTP-Treated Monkeys

P. Suzdak, J. Kordower, Y. Chu, 2001, Experimental Neurology.

Glutamic acid decarboxylase mRNA in rat brain: regional distribution and effects of intrastriatal kainic acid.

S. Paul, E. Ginns, A. Tobin, 1987, Brain research.

Neurochemical effects of IDPN on the mouse brain.

P. Suzdak, G. Gianutsos, 1985, Neurotoxicology.

Effect of the Mammalian Arginase Inhibitor 2(S)-Amino-6-Boronohexanoic Acid on Bacillus anthracis Arginase

B. Tomczuk, P. Suzdak, P. Shapiro, 2012, Current Microbiology.

Muscarinic agonists as analgesics. Antinociceptive activity versus M1 activity: SAR of alkylthio-TZTP's and related 1,2,5-thiadiazole analogs.

F. Bymaster, P. Suzdak, Michael D B Swedberg, 1995, Life sciences.

Xanomeline: An Efficacious and Specific M1 Receptor Agonist — Preclinical Update

F. Bymaster, P. Suzdak, Michael D B Swedberg, 1994 .

Parallel changes in the sensitivity of γ-aminobutyric acid and noradrenergic receptors following chronic administration of antidepressant and GABAergic drugs A possible role in affective disorders

P. Suzdak, G. Gianutsos, 1985, Neuropharmacology.

Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency.

S. Paul, P. Suzdak, A. Morrow, 1987, European journal of pharmacology.

Muscarinic analgesics with potent and selective effects on the gastrointestinal tract: potential application for the treatment of irritable bowel syndrome.

F. Bymaster, P. Suzdak, Michael D B Swedberg, 1997, Journal of medicinal chemistry.

The effect of chronic in vivo infusion of forskolin on noradrenergic receptor sensitivity

R. G. Browne, P. Suzdak, R. Browne, 2004, Psychopharmacology.

Chronic ethanol administration alters gamma-aminobutyric acid, pentobarbital and ethanol-mediated 36Cl- uptake in cerebral cortical synaptoneurosomes.

S. Paul, P. Suzdak, J. Karanian, 1988, The Journal of pharmacology and experimental therapeutics.

Effect of an imidazobenzodiazepine, Ro15-4513, on the incoordination and hypothermia produced by ethanol and pentobarbital.

S. Paul, P. Suzdak, B. Tabakoff, 1987, Life sciences.

(S)‐Carboxy‐3‐Hydroxyphenylglycine, an Antagonist of Metabotropic Glutamate Receptor (mGluR)1a and an Agonist of mGluR2, Protects Against Audiogenic Seizures in DBA/2 Mice

P. Suzdak, H. Jackson, C. Thomsen, 1994, Journal of neurochemistry.

4-Carboxy-3-hydroxyphenylglycine, an antagonist at type I metabotropic glutamate receptors.

P. Suzdak, C. Thomsen, 1993, European journal of pharmacology.

L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type iv metabotropic glutamate receptor which is negatively coupled to adenylate cyclase

P. Suzdak, E. Mulvihill, P. Kristensen, 1992 .

Important role of C-terminal peptide bonds for endothelin receptor binding and activity.

P. Suzdak, J. Weis, K. Madsen, 1993, Pharmacology & toxicology.

Differential coupling of GABA-A and GABA-B receptors to the noradrenergic system

P. Suzdak, G. Gianutsos, 2005, Journal of Neural Transmission.

Preparation of a potential positron emission tomographic radioligand for the dopamine transporter

C. Halldin, L. Farde, P. Suzdak, 1994, European Journal of Nuclear Medicine.

Effect of chronic imipramine or baclofen on GABA-B binding and cyclic AMP production in cerebral cortex.

P. Suzdak, G. Gianutsos, 1986, European journal of pharmacology.

The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug candidate.

P. Suzdak, F. Gronwald, C. Braestrup, 1993, Journal of medicinal chemistry.

Modulation of the Benzodiazepine/γ‐Aminobutyric Acid Receptor Chloride Channel Complex by Inhalation Anesthetics

P. Suzdak, P. Skolnick, S. Paul, 1988, Journal of neurochemistry.

Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors.

D. Wong, F. Bymaster, P. Suzdak, 1994, The Journal of pharmacology and experimental therapeutics.

Ethanol and the GABA receptor complex: Studies with the partial inverse benzodiazepine receptor agonist Ro 15-4513

S. Paul, J. Crawley, P. Suzdak, 1988, Pharmacology Biochemistry and Behavior.

Synthesis of novel GABA uptake inhibitors. Part 6: preparation and evaluation of N-Omega asymmetrically substituted nipecotic acid derivatives.

P. Suzdak, Michael D B Swedberg, J. Lau, 2001, Bioorganic & medicinal chemistry.

GABA-noradrenergic interaction: Evidence for differential sites of action for GABA-A and GABA-B receptors

P. Suzdak, G. Gianutsos, 2005, Journal of Neural Transmission.

Evidence for down-regulation of GABA receptors following long-term gamma-butyrolactone

P. Suzdak, G. Gianutsos, 1984, Naunyn-Schmiedeberg's Archives of Pharmacology.

Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor.

P. Suzdak, C. Thomsen, 1993, Neuroreport.

Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family.

P. Suzdak, E. Boel, C. Thomsen, 1994, European journal of pharmacology.

gamma-Aminobutyric acid (GABA)- and barbiturate-mediated 36Cl- uptake in rat brain synaptoneurosomes: evidence for rapid desensitization of the GABA receptor-coupled chloride ion channel.

S. Paul, P. Suzdak, R. D. Schwartz, 1986, Molecular pharmacology.

The effect of lorazepam tolerance and withdrawal on metabotropic glutamate receptor function.

P. Suzdak, M. Mortensen, C. Thomsen, 1995, The Journal of pharmacology and experimental therapeutics.

NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization.

P. Suzdak, E. B. Nielsen, K. Frederiksen, 1992, European journal of pharmacology.

(R)‐N‐[4,4‐Bis(3‐Methyl‐2‐Thienyl)but‐3‐en‐1‐yl]Nipecotic Acid Binds with High Affinity to the Brain γ‐Aminobutyric Acid Uptake Carrier

P. Suzdak, A. Mortensen, C. Braestrup, 1990, Journal of neurochemistry.

Anticonvulsant profile of the imidazoquinazolines NNC 14-0185 and NNC 14-0189 in rats and mice.

P. Suzdak, Michael D B Swedberg, M. Judge, 1996, European journal of pharmacology.

Molecular Cloning, Expression, and Characterization of Metabotropic Glutamate Receptor Subtypes

P. Suzdak, E. Mulvihill, P. Kristensen, 1994 .

Alcohols stimulate γ-aminobutyric acid receptor-mediated chloride uptake in brain vesicles: correlation with intoxication potency

S. Paul, P. Suzdak, R. D. Schwartz, 1988, Brain Research.

A selective imidazobenzodiazepine antagonist of ethanol in the rat.

Glowa, S. Paul, J. Crawley, 1986, Science.

Butylthio[2.2.2] (NNC 11-1053/LY297802): an orally active muscarinic agonist analgesic.

F. Bymaster, P. Suzdak, Michael D B Swedberg, 1997, The Journal of pharmacology and experimental therapeutics.

M1 receptor agonist activity is not a requirement for muscarinic antinociception.

F. Bymaster, P. Suzdak, Michael D B Swedberg, 1997, The Journal of pharmacology and experimental therapeutics.

Effect of the Mammalian Arginase Inhibitor 2(S)-Amino-6-Boronohexanoic Acid on Bacillus anthracis Arginase

B. Tomczuk, P. Suzdak, P. Shapiro, 2012, Current Microbiology.

A Review of the Preclinical Pharmacology of Tiagabine: A Potent and Selective Anticonvulsant GABA Uptake Inhibitor

P. Suzdak, J A Jansen, P D Suzdak, 1995, Epilepsia.

Neural actions of immunophilin ligands.

S. Snyder, D. Sabatini, P. Suzdak, 1998, Trends in pharmacological sciences.

Pharmacology of butylthio[2.2.2] (LY297802/NNC11-1053): a novel analgesic with mixed muscarinic receptor agonist and antagonist activity.

D. Wong, F. Bymaster, P. Suzdak, 1997, The Journal of pharmacology and experimental therapeutics.

A pharmacological characterization of the mGluR1α subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line

P. Suzdak, E. Mulvihill, D. Hampson, 1993, Brain Research.

A Comparison of Two Alternatively Spliced Forms of a Metabotropic Glutamate Receptor Coupled to Phosphoinositide Turnover

E. J. Fletcher, P. Suzdak, J. Macdonald, 1993, Journal of neurochemistry.

Effects of chronic tiagabine treatment on [3H]GABAA, [3H]GABAB and [3H]tiagabine binding to sections from mice brain

P. Suzdak, C. Thomsen, 1995, Epilepsy Research.

Lack of tolerance to the anticonvulsant effects of tiagabine following chronic (21 day) treatment

P. Suzdak, 1994, Epilepsy Research.

Quantitative autoradiographic characterization of the binding of [3H]tiagabine (NNC 05-328) to the GABA uptake carrier

P. Suzdak, C. Foged, K. Andersen, 1994, Brain Research.

3-(3-Alkylthio- 1,2,5-thiadiazol-4-yl)- 1 -azabicycles. Structure-activity relationships for antinociception mediated by central muscarinic receptors

F. Bymaster, P. Suzdak, Michael D B Swedberg, 1996 .

Benzodiazepine, barbiturate, ethanol and hypnotic steroid hormone modulation of GABA-mediated chloride ion transport in rat brain synaptoneurosomes.

S. Paul, P. Suzdak, A. Morrow, 1988, Advances in biochemical psychopharmacology.

Response: is ethanol antagonist rol5-4513 selective for ethanol?

S. Paul, J. Crawley, P. Suzdak, 1988, Science.

Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor.

P. Suzdak, C. Braestrup, U. Sonnewald, 1991, European journal of pharmacology.

Pyrazolo[1,5-a]pyridines and pyrazolo[1,5-b]pyridazines as 5ht3-antagonists

P. Suzdak, J. Hansen, K. Eskesen, 1994 .

AMPA, but not NMDA, receptor antagonism is neuroprotective in gerbil global ischaemia, even when delayed 24 h.

P. Suzdak, M. Sheardown, L. Nordholm, 1993, European journal of pharmacology.

Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents.

P. Suzdak, Michael D B Swedberg, R. Henry, 1999, Journal of medicinal chemistry.

Characterization of the metabotropic glutamate receptor in mouse cerebellar granule cells: lack of effect of 2,3-dihydroxy-6-nitro-7-sulphamoylbenzo(F)-quinoxaline (NBQX).

P. Suzdak, T. Honoré, M. Sheardown, 1993, European journal of pharmacology.

Neurochemical effects of the M1 muscarinic agonist xanomeline (LY246708/NNC11-0232).

D. Wong, F. Bymaster, P. Suzdak, 1994, The Journal of pharmacology and experimental therapeutics.

Expression pattern and pharmacology of the rat type IV metabotropic glutamate receptor

P. Suzdak, P. Kristensen, C. Thomsen, 1993, Neuroscience Letters.

Effects of Ro15-4513 and other benzodiazepine receptor inverse agonists on alcohol-induced intoxication in the rat.

S. Paul, J. Crawley, P. Suzdak, 1988, The Journal of pharmacology and experimental therapeutics.

SYNTHESIS AND STRUCTURE ACTIVITY RELATIONSHIPS OF ALKYL SUBSTITUTED ANALOGUES OF THE FUNCTIONAL M1 SELECTIVE MUSCARINIC RECEPTOR AGONIST XANOMELINE

F. Bymaster, P. Suzdak, C. Mitch, 1994 .

GABAergic effects of reserpine following chronic treatment

P. Suzdak, G. Gianutsos, Gerald Gianutsos, 2004, Psychopharmacology.

Conformational properties of α‐ and β‐azabicyclane opiates. The effect of conformation on pharmacological activity

P. Suzdak, M. Froimowitz, R. Heyman, 1984 .

Synthesis and binding properties of [3H]NNC 12-0781, a new radioligand for the dopamine reuptake system.

C. Halldin, L. Farde, P. Suzdak, 1995, Nuclear medicine and biology.

Cerebellar GABAA receptors in two rat lines selected for high and low sensitivity to moderate alcohol doses: pharmacological and genetic studies.

E. Castrén, P. Suzdak, E. Korpi, 1992, Alcohol.

Constrained C-terminal hexapeptide neurotensin analogues containing a 3-oxoindolizidine skeleton

P. Suzdak, M. García-López, R. González-Muñiz, 1995, Letters in Peptide Science.

Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models.

J. H. Li, P. Suzdak, H. Guo, 1997, Proceedings of the National Academy of Sciences of the United States of America.

l‐Glutamate Uptake Inhibitors May Stimulate Phosphoinositide Hydrolysis in Baby Hamster Kidney Cells Expressing mGluR1a via Heteroexchange with l‐Glutamate Without Direct Activation of mGluR1a

P. Suzdak, C. Thomsen, L. Hansen, 1994, Journal of neurochemistry.

Structure-activity relationships of endothelin analogs

P. Suzdak, K. Madsen, H. Thøgersen, 1991 .

Synthesis of novel GABA uptake inhibitors. 4. Bioisosteric transformation and successive optimization of known GABA uptake inhibitors leading to a series of potent anticonvulsant drug candidates.

P. Suzdak, Michael D B Swedberg, J. Sorensen, 1999, Journal of medicinal chemistry.

Synthesis of Novel γ-Aminobutyric Acid (GABA) Uptake Inhibitors. Part 5. Preparation and Structure—Activity Studies of Tricyclic Analogues of Known GABA Uptake Inhibitors.

P. Suzdak, Michael D B Swedberg, J. Lau, 2001 .

Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors.

P. Suzdak, Michael D B Swedberg, J. Sorensen, 2001, Journal of medicinal chemistry.

In vivo labeling of the central GABA uptake carrier with 3H-Tiagabine.

P. Suzdak, Michael D B Swedberg, C. Braestrup, 1992, Life Science.

Tolerance to the cognitive impairing effects but not the anticonvulsant effects of NO-328, a selective GABA uptake inhibitor

P. Suzdak, Michael D B Swedberg, M. Judge, 1990 .

Effects of t-ACPD on neural survival and second messengers in cultured cerebral cortical neurones.

A. Schousboe, P. Suzdak, A. Frandsen, 1993, Neuroreport.

Pharmacology of Excitatory Amino Acid Receptors

S. Heinemann, P. Suzdak, J. Bockaert, 1995 .

Response : Seizures in Drug-Treated Animals

J. Crawley, P. Suzdak, R. D. Schwartz, 1987, Science.

Effect of the Non‐NMDA Receptor Antagonist, 2,3‐Dihydro‐6‐Nitro‐7‐Sulfamoylbenzo(f)quinoxaline, on Local Cerebral Glucose Uptake in the Limbic Forebrain

P. Suzdak, M. Sheardown, 1993, Journal of neurochemistry.

L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase.

P. Suzdak, E. Mulvihill, P. Kristensen, 1993, European journal of pharmacology.