A. Degterev

E. Lo, D. Kaplan, A. Degterev, 2020, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Microsoft Word-JBC_Cyld_Manuscript_revised.docx

A. Degterev, A. Poltorak, I. Smirnova, 2014 .

Akt and mTOR mediate programmed necrosis in neurons

E. Lo, A. Degterev, M. Whalen, 2014, Cell Death and Disease.

Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5.

A. Degterev, Junying Yuan, C. Yuan, 2007, Bioorganic & medicinal chemistry letters.

Structure—Activity Relationship Analysis of a Novel Necroptosis Inhibitor, Necrostatin-5 (VIa).

A. Degterev, Junying Yuan, C. Yuan, 2007 .

Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors.

A. Degterev, Junying Yuan, Heather R. Keys, 2008, Bioorganic & medicinal chemistry letters.

Structure-activity relationship study of tricyclic necroptosis inhibitors.

A. Degterev, Junying Yuan, Heather R. Keys, 2007, Journal of medicinal chemistry.

Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors.

A. Degterev, Junying Yuan, Heather R. Keys, 2007, Bioorganic & medicinal chemistry letters.

Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability.

A. Degterev, Junying Yuan, Heather R. Keys, 2012, Bioorganic & medicinal chemistry letters.

Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling

Jennifer A. Ward, A. Degterev, A. Bullock, 2018, The EMBO journal.

Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice

M. Moskowitz, A. Degterev, Junying Yuan, 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Phenytoin inhibits necroptosis

D. Green, A. Degterev, S. Bornstein, 2018, Cell Death & Disease.

RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4.

J. Bertin, A. Degterev, M. Pasparakis, 2016, Immunity.

A global atlas of substrate specificities for the human serine/threonine kinome

Jared L. Johnson, O. Elemento, J. Blenis, 2022, bioRxiv.

ZBP1 promotes inflammatory responses downstream of TLR3/TLR4 via timely delivery of RIPK1 to TRIF

A. Degterev, A. Poltorak, I. Smirnova, 2022, Proceedings of the National Academy of Sciences of the United States of America.

The role of NF-1 factors in regulation of elastin gene transcription.

A. Degterev, J. Foster, 1999, Matrix biology : journal of the International Society for Matrix Biology.

Small molecule inhibitors reveal an indispensable scaffolding role of RIPK 2 in NOD 2 signaling

Jennifer A. Ward, A. Degterev, A. Bullock, 2018 .

Retinal ganglion cell (RGC) programmed necrosis contributes to ischemia-reperfusion-induced retinal damage.

A. Degterev, Galina Dvoriantchikova, Dmitry Ivanov, 2014, Experimental eye research.

Genetic inhibition of RIPK3 ameliorates functional outcome in controlled cortical impact independent of necroptosis

E. Lo, D. Kaplan, A. Degterev, 2021, Cell Death & Disease.

Genetic Inhibition of Receptor Interacting Protein Kinase-1 Reduces Cell Death and Improves Functional Outcome After Intracerebral Hemorrhage in Mice

J. Bertin, E. Lo, A. Degterev, 2017, Stroke.

The regulation of necroptosis and perspectives for the development of new drugs preventing ischemic/reperfusion of cardiac injury

A. Degterev, Nirmal Singh, A. Boshchenko, 2022, Apoptosis.

Methods to analyze cellular necroptosis.

B. Miao, A. Degterev, 2009, Methods in molecular biology.

A new savior for neurons

A. Degterev, Junying Yuan, 1999, Nature Neuroscience.

Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase

A. Degterev, Junying Yuan, J. Maki, 2012, Cell Death and Differentiation.

Caspase-Dependent Suppression of Type I Interferon Signaling Promotes Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication

A. Degterev, M. Gaglia, Tate Tabtieng, 2018, Journal of Virology.

ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1

A. Degterev, A. Poltorak, I. Smirnova, 2021, Nature Communications.

Identification of Small Molecule Inhibitors of Neurite Loss Induced by Aβ peptide using High Content Screening*

Stephen T. C. Wong, Jing Fan, Alexei Degterev, 2012, The Journal of Biological Chemistry.

Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7.

A. Degterev, Junying Yuan, C. Yuan, 2008, Bioorganic & medicinal chemistry letters.

A Combined Experimental and Density Functional Theory Study on the Pd‐Mediated Cycloisomerization of o‐Alkynylnitrobenzenes – Synthesis of Isatogens and Their Evaluation as Modulators of ROS‐Mediated Cell Death

B. Miao, A. Degterev, Pitambar Patel, 2010 .

In vitro cytotoxicity of novel pro-apoptotic agent DM-PIT-1 in PEG-PE-based micelles alone and in combination with TRAIL

B. Miao, A. Degterev, V. Torchilin, 2009, Drug delivery.

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

P. Vandenabeele, G. Prendergast, A. Degterev, 2012, Cell Death and Disease.

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

Alexei Degterev, Junying Yuan, Timothy J Mitchison, 2005, Nature chemical biology.

Targeting RIPK1 for the treatment of human diseases

A. Degterev, Junying Yuan, D. Ofengeim, 2019, Proceedings of the National Academy of Sciences.

Structural basis of RIP1 inhibition by necrostatins.

Yigong Shi, A. Degterev, Junying Yuan, 2013, Structure.

Necroptosis, a novel form of caspase‐independent cell death, contributes to neuronal damage in a retinal ischemia‐reperfusion injury model

J. Grotta, A. Degterev, Junying Yuan, 2009, Journal of neuroscience research.

Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

A. Degterev, M. Andrake, G. Rall, 2013, Proceedings of the National Academy of Sciences.

Erratum: Corrigendum: Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

M. Moskowitz, T. Mitchison, A. Degterev, 2005 .

Optimization of the anti-cancer activity of phosphatidylinositol-3 kinase pathway inhibitor PITENIN-1: switching a thiourea with 1,2,3-triazole.

A. Degterev, V. Torchilin, C. Ramana, 2014, MedChemComm.

Cell Death: Biological Mechanisms and Small Molecule Inhibitors

A. Degterev, O. Korkina, 2008 .

Role of phosphatidylinositol 3,4,5-trisphosphate in cell signaling.

A. Degterev, R. Riehle, Sinziana Cornea, 2013, Advances in experimental medicine and biology.

Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1.

J. Bertin, A. Degterev, Junying Yuan, 2015, Cell reports.

Phenytoin inhibits necroptosis

D. Green, A. Degterev, S. Bornstein, 2018, Cell Death & Disease.

Small-molecule inhibitors of the PI3K signaling network.

A. Degterev, Colleen Mcnamara, 2011, Future medicinal chemistry.

RIPK1 and RIPK3 – emerging targets in cancer?

A. Degterev, K. Gurol, Suraj Shah, 2018, Molecular and Cellular Therapies.

Regulation of Intracellular Accumulation of Mutant Huntingtin by Beclin 1*

Alexei Degterev, Junying Yuan, Tao Lu, 2006, Journal of Biological Chemistry.

A genome-wide RNAi screen reveals multiple regulators of caspase activation

A. Degterev, Junying Yuan, M. Boyce, 2007, The Journal of cell biology.

Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.

A. Degterev, Danish Saleh, K. W. Wegner, 2017, Trends in pharmacological sciences.

Toll-like Receptor-mediated Down-regulation of the Deubiquitinase Cylindromatosis (CYLD) Protects Macrophages from Necroptosis in Wild-derived Mice*

A. Degterev, A. Poltorak, I. Smirnova, 2014, The Journal of Biological Chemistry.

Generation of small molecules to interfere with regulated necrosis

A. Degterev, A. Linkermann, 2016, Cellular and Molecular Life Sciences.

Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains

B. Miao, A. Degterev, Junying Yuan, 2010, Proceedings of the National Academy of Sciences.

Emerging Roles for RIPK1 and RIPK3 in Pathogen-Induced Cell Death and Host Immunity.

A. Degterev, Danish Saleh, 2015, Current topics in microbiology and immunology.

Molecular pathways involved in cell death after chemically induced DNA damage.

A. Degterev, M. R. Calera, R. Sánchez-Olea, 2009, EXS.

An atlas of substrate specificities for the human serine/threonine kinome

Jared L. Johnson, O. Elemento, J. Blenis, 2023, Nature.

A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors.

Junying Yuan, Gerhard Wagner, A. Degterev, 2002, Journal of the American Chemical Society.

Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors

A. Degterev, A. Bullock, S. Ray, 2015, Chemistry & biology.

Automated neurite labeling and analysis in fluorescence microscopy images

Xiaobo Zhou, Guanglei Xiong, Alexei Degterev, 2006, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold.

A. Degterev, A. Bullock, L. Schlicher, 2020, European journal of medicinal chemistry.

Antigen-mediated T cell expansion regulated by parallel pathways of death

Daniel R. Beisner, A. Hoffmann, A. Degterev, 2008, Proceedings of the National Academy of Sciences.

Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation

N. Sonenberg, A. Degterev, A. Poltorak, 2020, Cell reports.

Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide

J. Bertin, N. Slavov, A. Degterev, 2017, The Journal of Immunology.

Targeting energy metabolism of cancer cells: Combined administration of NCL-240 and 2-DG.

A. Degterev, V. Torchilin, J. Baleja, 2017, International journal of pharmaceutics.

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

S. Hersch, S. Tabrizi, B. Leavitt, 2017, Proceedings of the National Academy of Sciences.

Combination Therapy Targeting Akt and Mammalian Target of Rapamycin Improves Functional Outcome after Controlled Cortical Impact in Mice

E. Lo, A. Degterev, M. Whalen, 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Role of Akt and Mammalian Target of Rapamycin in Functional Outcome after Concussive Brain Injury in Mice

E. Lo, A. Degterev, M. Whalen, 2014, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

A novel tracing algorithm for high throughput imaging Screening of neuron-based assays

Yong Zhang, Xiaobo Zhou, Stephen T. C. Wong, 2007, Journal of Neuroscience Methods.

Assays for necroptosis and activity of RIP kinases.

A. Degterev, Junying Yuan, Wen Zhou, 2014, Methods in enzymology.

Expression and purification of active receptor interacting protein 1 kinase using a baculovirus system.

A. Degterev, G. Cuny, Xin-Chen Teng, 2013, Protein expression and purification.

Akt Regulates TNFα Synthesis Downstream of RIP1 Kinase Activation during Necroptosis

A. Degterev, S. Gerber, A. Kettenbach, 2013, PloS one.

Apoptotic cell death in disease—Current understanding of the NCCD 2023

S. Lipton, A. Ciechanover, T. Luedde, 2023, Cell Death & Differentiation.

The channel of death

A. Degterev, Junying Yuan, M. Boyce, 2001, The Journal of cell biology.

Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors

A. Degterev, A. Bullock, S. Ray, 2018, Bioorganic & medicinal chemistry letters.

A HPLC method for the quantitative determination of N-(2-hydroxy-5-nitrophenylcarbamothioyl)-3,5-dimethylbenzamide in biological samples.

A. Degterev, V. Torchilin, I. Skidan, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Human Receptor-Interacting Serine / Threonine-Protein Kinase 2 ( RIPK 2 ) A Target Enabling Package ( TEP )

Jennifer A. Ward, S. Knapp, A. Degterev, 2020 .

Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1.

A. Degterev, S. Ray, G. Cuny, 2012, Analytical biochemistry.

Targeting phospshatidylinositol 3-kinase signaling with novel phosphatidylinositol 3,4,5-triphosphate antagonists

B. Miao, A. Degterev, 2011, Autophagy.

Cytotoxicity of PEGylated liposomes co-loaded with novel pro-apoptotic drug NCL-240 and the MEK inhibitor cobimetinib against colon carcinoma in vitro.

A. Degterev, V. Torchilin, E. Luther, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling.

A. Degterev, L. Schlicher, Seungheon Lee, 2021, European journal of medicinal chemistry.

Chemical Library Screens to Identify Pharmacological Modulators of Necroptosis.

A. Degterev, Danish Saleh, 2018, Methods in molecular biology.

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

S. Hersch, S. Tabrizi, B. Leavitt, 2017, Proceedings of the National Academy of Sciences.

Guidelines for the use and interpretation of assays for monitoring autophage

T. P. Neufeld, Thomas J. Begley, H. Coller, 2012 .

Activity assays for receptor-interacting protein kinase 1:a key regulator of necroptosis.

A. Degterev, Jenny L. Maki, 2013, Methods in molecular biology.

A computational framework for studying neuron morphology from in vitro high content neuron-based screening

Xiaobo Zhou, Stephen T. C. Wong, Yue Huang, 2010, Journal of Neuroscience Methods.

Necroptosis blockade prevents lung injury in severe influenza.

David F. Boyd, A. Degterev, J. Crawford, 2024, Nature.

RIPK1 activation mediates neuroinﬂammation and disease progression in multiple sclerosis

A. Degterev, D. Ofengeim, Matija Zelic, 2022 .

AI is a viable alternative to high throughput screening: a 318-target study

Eva M García-Cuesta, Frederick S. Vizeacoumar, Stephen J. Capuzzi, 2024, Scientific reports.

Non-canonical autophosphorylation of RIPK1 drives timely pyroptosis to control Yersinia infection

A. Degterev, J. Mecsas, I. Smirnova, 2024, Cell reports.

An image based system biology approach for Alzheimer's disease pathway analysis

Stephen T. C. Wong, Guangshu Hu, Zheng Xia, 2009, 2009 IEEE/NIH Life Science Systems and Applications Workshop.